http://togogenome.org/gene/9483:TSEN54 ^@ http://purl.uniprot.org/uniprot/F7INL6 ^@ Similarity ^@ Belongs to the SEN54 family. http://togogenome.org/gene/9483:UNC5D ^@ http://purl.uniprot.org/uniprot/A0A2R8MK76|||http://purl.uniprot.org/uniprot/A0A8I3WKF9|||http://purl.uniprot.org/uniprot/F7IHE0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-5 family.|||Cell membrane|||Membrane|||Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. http://togogenome.org/gene/9483:LOC100411313 ^@ http://purl.uniprot.org/uniprot/U3CJ57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family.|||Nucleus http://togogenome.org/gene/9483:KRT18 ^@ http://purl.uniprot.org/uniprot/F6RWB1 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9483:OLFR600 ^@ http://purl.uniprot.org/uniprot/B0VXA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:PCNA ^@ http://purl.uniprot.org/uniprot/U3CWY2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PCNA family.|||Nucleus|||This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. http://togogenome.org/gene/9483:GJA8 ^@ http://purl.uniprot.org/uniprot/A0A654IC84 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9483:LEO1 ^@ http://purl.uniprot.org/uniprot/F7CCM6 ^@ Similarity ^@ Belongs to the LEO1 family. http://togogenome.org/gene/9483:EDNRA ^@ http://purl.uniprot.org/uniprot/F6YN68 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with HDAC7 and KAT5.|||Membrane|||Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. http://togogenome.org/gene/9483:VTI1B ^@ http://purl.uniprot.org/uniprot/F7AQT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/9483:MSTN ^@ http://purl.uniprot.org/uniprot/F6Y9D0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts specifically as a negative regulator of skeletal muscle growth.|||Belongs to the TGF-beta family.|||Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FSTL3.|||Secreted http://togogenome.org/gene/9483:SRP14 ^@ http://purl.uniprot.org/uniprot/A0A8I3XD27 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SRP14 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.|||Cytoplasm|||Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. http://togogenome.org/gene/9483:CSRNP2 ^@ http://purl.uniprot.org/uniprot/F7EDZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AXUD1 family.|||Nucleus http://togogenome.org/gene/9483:CD244 ^@ http://purl.uniprot.org/uniprot/U3DBJ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:LOC100403816 ^@ http://purl.uniprot.org/uniprot/F7IA43 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9483:IL17B ^@ http://purl.uniprot.org/uniprot/A0A5F4WDJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/9483:LOC100895074 ^@ http://purl.uniprot.org/uniprot/A0A8I3WPI3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9483:TAF15 ^@ http://purl.uniprot.org/uniprot/F7GUE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TET family.|||Nucleus http://togogenome.org/gene/9483:SLC9A2 ^@ http://purl.uniprot.org/uniprot/F6SCS6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Interacts with CHP1 and CHP2.|||Membrane http://togogenome.org/gene/9483:LGI2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YCU6 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9483:PPP1R15B ^@ http://purl.uniprot.org/uniprot/F7IF39 ^@ Similarity ^@ Belongs to the PPP1R15 family. http://togogenome.org/gene/9483:TMEM168 ^@ http://purl.uniprot.org/uniprot/U3C6I5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM168 family.|||Membrane|||Nucleus membrane http://togogenome.org/gene/9483:ADRA1A ^@ http://purl.uniprot.org/uniprot/A0A8I3X918|||http://purl.uniprot.org/uniprot/A0A8I3XFH9|||http://purl.uniprot.org/uniprot/F6QIG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Membrane|||Nucleus membrane|||caveola http://togogenome.org/gene/9483:NSMCE4A ^@ http://purl.uniprot.org/uniprot/F7HV64 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NSE4 family.|||Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.|||Component of the SMC5-SMC6 complex.|||Nucleus|||telomere http://togogenome.org/gene/9483:EDC3 ^@ http://purl.uniprot.org/uniprot/F7ERK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EDC3 family.|||P-body http://togogenome.org/gene/9483:ARL4C ^@ http://purl.uniprot.org/uniprot/U3FEV8 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9483:TGFB2 ^@ http://purl.uniprot.org/uniprot/F7G0A3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.|||extracellular matrix http://togogenome.org/gene/9483:FAM131A ^@ http://purl.uniprot.org/uniprot/F7H4H4 ^@ Similarity ^@ Belongs to the FAM131 family. http://togogenome.org/gene/9483:TOR1AIP1 ^@ http://purl.uniprot.org/uniprot/A0A5F4VZ85|||http://purl.uniprot.org/uniprot/U3CW96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TOR1AIP family.|||Membrane http://togogenome.org/gene/9483:IL1B ^@ http://purl.uniprot.org/uniprot/F6RH14 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-1 family.|||IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.|||Lysosome|||Monomer. Interacts with MEFV.|||Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.|||Secreted|||cytosol|||extracellular exosome http://togogenome.org/gene/9483:SLC35B4 ^@ http://purl.uniprot.org/uniprot/U3D595 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/9483:TRIM26 ^@ http://purl.uniprot.org/uniprot/F7IQQ8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRIM/RBCC family.|||Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:TOP2B ^@ http://purl.uniprot.org/uniprot/U3BD56 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II topoisomerase family.|||Homodimer.|||Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9483:ARPIN ^@ http://purl.uniprot.org/uniprot/U3FN27 ^@ Similarity ^@ Belongs to the Arpin family. http://togogenome.org/gene/9483:ALKBH2 ^@ http://purl.uniprot.org/uniprot/F7GQA0 ^@ Similarity ^@ Belongs to the alkB family. http://togogenome.org/gene/9483:FURIN ^@ http://purl.uniprot.org/uniprot/U3FS81 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9483:APLP2 ^@ http://purl.uniprot.org/uniprot/F7D967|||http://purl.uniprot.org/uniprot/F7I340|||http://purl.uniprot.org/uniprot/U3FVA2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APP family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:TFDP2 ^@ http://purl.uniprot.org/uniprot/A0A8I3WXA2|||http://purl.uniprot.org/uniprot/U3FFN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9483:RPAIN ^@ http://purl.uniprot.org/uniprot/A0A2R8M5T4|||http://purl.uniprot.org/uniprot/F7GVG1|||http://purl.uniprot.org/uniprot/U3ETR1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:SESN2 ^@ http://purl.uniprot.org/uniprot/A0A2R8P1V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/9483:PDIA3 ^@ http://purl.uniprot.org/uniprot/B0KWG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9483:DEFB128 ^@ http://purl.uniprot.org/uniprot/A0A8I3W5R0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9483:FABP7 ^@ http://purl.uniprot.org/uniprot/U3EM14 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9483:C14H2orf68 ^@ http://purl.uniprot.org/uniprot/F7DPH6 ^@ Similarity ^@ Belongs to the UPF0561 family. http://togogenome.org/gene/9483:NSMCE2 ^@ http://purl.uniprot.org/uniprot/F7HZF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NSE2 family.|||Nucleus http://togogenome.org/gene/9483:MAOB ^@ http://purl.uniprot.org/uniprot/F7IRJ7 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/9483:AGTRAP ^@ http://purl.uniprot.org/uniprot/U3CLC5|||http://purl.uniprot.org/uniprot/U3FGS3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:TLR9 ^@ http://purl.uniprot.org/uniprot/F7HZH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.|||cytoskeleton http://togogenome.org/gene/9483:GCLM ^@ http://purl.uniprot.org/uniprot/Q2I825 ^@ Similarity|||Subunit ^@ Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.|||Heterodimer of a catalytic heavy chain and a regulatory light chain. http://togogenome.org/gene/9483:LOC100400759 ^@ http://purl.uniprot.org/uniprot/A0A2R8MD14 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the translin family.|||DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.|||Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.|||Nucleus|||Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring. http://togogenome.org/gene/9483:LOC100393317 ^@ http://purl.uniprot.org/uniprot/F7CCF9 ^@ Similarity ^@ Belongs to the CLCR family. http://togogenome.org/gene/9483:OLFR561 ^@ http://purl.uniprot.org/uniprot/B0VX91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:CBFB ^@ http://purl.uniprot.org/uniprot/F7BRE0|||http://purl.uniprot.org/uniprot/U3FT28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CBF-beta family.|||Nucleus http://togogenome.org/gene/9483:FUCA2 ^@ http://purl.uniprot.org/uniprot/A0A8I3WDS3|||http://purl.uniprot.org/uniprot/A0A8I3WY39|||http://purl.uniprot.org/uniprot/A0A8I3XDK9 ^@ Function|||Similarity|||Subunit ^@ Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.|||Belongs to the glycosyl hydrolase 29 family.|||Homotetramer. http://togogenome.org/gene/9483:PGLYRP1 ^@ http://purl.uniprot.org/uniprot/F6V9G7 ^@ Function|||Similarity ^@ Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.|||Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. http://togogenome.org/gene/9483:SERPINA11 ^@ http://purl.uniprot.org/uniprot/F7I7B1 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9483:RPL28 ^@ http://purl.uniprot.org/uniprot/F6VGW5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL28 family. http://togogenome.org/gene/9483:IL1R1 ^@ http://purl.uniprot.org/uniprot/U3DT41 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9483:UBLCP1 ^@ http://purl.uniprot.org/uniprot/U3FI55 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:MEP1B ^@ http://purl.uniprot.org/uniprot/F7I1Y3 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:CYP4F11 ^@ http://purl.uniprot.org/uniprot/A0A1P8NQK8 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9483:PRPF4 ^@ http://purl.uniprot.org/uniprot/U3C117 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/9483:TIGD4 ^@ http://purl.uniprot.org/uniprot/F7HQK9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:LOC100401074 ^@ http://purl.uniprot.org/uniprot/A0A5F4VXW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9483:PITHD1 ^@ http://purl.uniprot.org/uniprot/F7I905 ^@ Similarity ^@ Belongs to the PITHD1 family. http://togogenome.org/gene/9483:AMPD3 ^@ http://purl.uniprot.org/uniprot/F7H1G4 ^@ Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.|||Homotetramer. http://togogenome.org/gene/9483:AQP11 ^@ http://purl.uniprot.org/uniprot/A0A2R8MJH3|||http://purl.uniprot.org/uniprot/A0A2R8MP89|||http://purl.uniprot.org/uniprot/F7ELM9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.|||Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.|||Membrane http://togogenome.org/gene/9483:IZUMO2 ^@ http://purl.uniprot.org/uniprot/F6Y8E8 ^@ Similarity ^@ Belongs to the Izumo family. http://togogenome.org/gene/9483:SLC39A14 ^@ http://purl.uniprot.org/uniprot/A0A8I3WME3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:MYBL1 ^@ http://purl.uniprot.org/uniprot/F7HNE8|||http://purl.uniprot.org/uniprot/F7ISE4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:PSMD7 ^@ http://purl.uniprot.org/uniprot/F7E772 ^@ Similarity ^@ Belongs to the peptidase M67A family. http://togogenome.org/gene/9483:AQP9 ^@ http://purl.uniprot.org/uniprot/A0A8I3WZ16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9483:MINDY1 ^@ http://purl.uniprot.org/uniprot/F7C0Z2 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM63 subfamily.|||Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover. http://togogenome.org/gene/9483:DDX41 ^@ http://purl.uniprot.org/uniprot/U3F2W6 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX41 subfamily. http://togogenome.org/gene/9483:AQP3 ^@ http://purl.uniprot.org/uniprot/F7CWZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:RNASET2 ^@ http://purl.uniprot.org/uniprot/U3DHH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase T2 family.|||Lysosome lumen http://togogenome.org/gene/9483:LOC100410496 ^@ http://purl.uniprot.org/uniprot/F7I9S2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family. PP-1 subfamily.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9483:FNBP1L ^@ http://purl.uniprot.org/uniprot/F7G804 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNBP1 family.|||Cell membrane|||Cytoplasmic vesicle|||Membrane|||Vesicle|||cell cortex|||cytoskeleton http://togogenome.org/gene/9483:SDHAF4 ^@ http://purl.uniprot.org/uniprot/U3FCZ6 ^@ Similarity ^@ Belongs to the SDHAF4 family. http://togogenome.org/gene/9483:CKAP5 ^@ http://purl.uniprot.org/uniprot/U3EY20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TOG/XMAP215 family.|||kinetochore http://togogenome.org/gene/9483:PLCB2 ^@ http://purl.uniprot.org/uniprot/A0A5F4WH25|||http://purl.uniprot.org/uniprot/F7I4D1 ^@ Cofactor|||Function ^@ Binds 1 Ca(2+) ion per subunit.|||The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. http://togogenome.org/gene/9483:WASF3 ^@ http://purl.uniprot.org/uniprot/F7GRX8|||http://purl.uniprot.org/uniprot/F7GRZ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCAR/WAVE family.|||Binds actin and the Arp2/3 complex.|||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|||cytoskeleton http://togogenome.org/gene/9483:DTWD2 ^@ http://purl.uniprot.org/uniprot/A0A2R8M4C7 ^@ Similarity ^@ Belongs to the TDD superfamily. DTWD2 family. http://togogenome.org/gene/9483:MGAT5 ^@ http://purl.uniprot.org/uniprot/U3BBB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 18 family.|||Golgi apparatus membrane|||Membrane|||Secreted http://togogenome.org/gene/9483:TGFBR2 ^@ http://purl.uniprot.org/uniprot/A0A2R8MMC4|||http://purl.uniprot.org/uniprot/F6ZQQ5|||http://purl.uniprot.org/uniprot/U3B8Z8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Cell membrane|||Membrane|||Membrane raft|||Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. http://togogenome.org/gene/9483:METTL15 ^@ http://purl.uniprot.org/uniprot/A0A8I3WZN5 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. RsmH family. http://togogenome.org/gene/9483:PSMB10 ^@ http://purl.uniprot.org/uniprot/U3DF12 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:LOC100389518 ^@ http://purl.uniprot.org/uniprot/A0A2R8N9P5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS10 family. http://togogenome.org/gene/9483:LOC100405000 ^@ http://purl.uniprot.org/uniprot/F6RXN0 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL11 family.|||Binds directly to 26S ribosomal RNA. http://togogenome.org/gene/9483:ADCY9 ^@ http://purl.uniprot.org/uniprot/F6RS83 ^@ Similarity ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. http://togogenome.org/gene/9483:OLFM3 ^@ http://purl.uniprot.org/uniprot/A0A2R8MJD5 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/9483:LOC100411683 ^@ http://purl.uniprot.org/uniprot/B0VXB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:PICALM ^@ http://purl.uniprot.org/uniprot/A0A2R8N784|||http://purl.uniprot.org/uniprot/F7IBR4|||http://purl.uniprot.org/uniprot/U3BSF3|||http://purl.uniprot.org/uniprot/U3CPA6|||http://purl.uniprot.org/uniprot/U3DBE5|||http://purl.uniprot.org/uniprot/U3FFE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PICALM/SNAP91 family.|||Membrane http://togogenome.org/gene/9483:LOC100386265 ^@ http://purl.uniprot.org/uniprot/A0A8I4A6I7 ^@ Similarity ^@ Belongs to the histone H3 family. http://togogenome.org/gene/9483:AK2 ^@ http://purl.uniprot.org/uniprot/U3BWM8|||http://purl.uniprot.org/uniprot/U3DKZ4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK2 subfamily.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Mitochondrion intermembrane space|||Monomer. http://togogenome.org/gene/9483:SLC66A3 ^@ http://purl.uniprot.org/uniprot/U3FIZ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:BANF2 ^@ http://purl.uniprot.org/uniprot/A0A8I3WH01 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:HSPA9 ^@ http://purl.uniprot.org/uniprot/U3D3A7 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9483:BCLAF1 ^@ http://purl.uniprot.org/uniprot/U3B5H4|||http://purl.uniprot.org/uniprot/U3CYS9|||http://purl.uniprot.org/uniprot/U3F318|||http://purl.uniprot.org/uniprot/U3F882 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BCLAF1/THRAP3 family.|||Belongs to the CASC3 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:POLR1E ^@ http://purl.uniprot.org/uniprot/U3CEZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.|||nucleolus http://togogenome.org/gene/9483:DCTN6 ^@ http://purl.uniprot.org/uniprot/F7HWQ5|||http://purl.uniprot.org/uniprot/U3EUQ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.|||Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.|||cytoskeleton http://togogenome.org/gene/9483:EYA1 ^@ http://purl.uniprot.org/uniprot/F7IGE4 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/9483:PITPNM1 ^@ http://purl.uniprot.org/uniprot/U3CSB1|||http://purl.uniprot.org/uniprot/U3FWY1 ^@ Similarity ^@ Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily. http://togogenome.org/gene/9483:INPP5K ^@ http://purl.uniprot.org/uniprot/U3D8K9 ^@ Similarity ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family. http://togogenome.org/gene/9483:CRCP ^@ http://purl.uniprot.org/uniprot/F6TNU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC9 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/9483:PSMG1 ^@ http://purl.uniprot.org/uniprot/B0KW86|||http://purl.uniprot.org/uniprot/U3C6S6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PSMG1 family.|||Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization (By similarity).|||Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.|||Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2.|||Cytoplasm|||Degraded by the proteasome upon completion of 20S proteasome maturation.|||Endoplasmic reticulum|||Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits (By similarity).|||Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits.|||Forms a heterodimer with psmg2. http://togogenome.org/gene/9483:OGN ^@ http://purl.uniprot.org/uniprot/F7INR0 ^@ Similarity ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. http://togogenome.org/gene/9483:HARBI1 ^@ http://purl.uniprot.org/uniprot/F6TKC2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HARBI1 family.|||Cytoplasm|||Nucleus|||Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity. http://togogenome.org/gene/9483:ZSCAN2 ^@ http://purl.uniprot.org/uniprot/A0A8I3WID1|||http://purl.uniprot.org/uniprot/U3FGU6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:MS4A2 ^@ http://purl.uniprot.org/uniprot/F6RHF4 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9483:TRIM3 ^@ http://purl.uniprot.org/uniprot/F6X294 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm http://togogenome.org/gene/9483:SMPDL3A ^@ http://purl.uniprot.org/uniprot/F7AAZ3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acid sphingomyelinase family.|||Binds 2 Zn(2+) per subunit.|||Secreted http://togogenome.org/gene/9483:NUP62 ^@ http://purl.uniprot.org/uniprot/F7IJB9 ^@ Similarity ^@ Belongs to the nucleoporin NSP1/NUP62 family. http://togogenome.org/gene/9483:NRTN ^@ http://purl.uniprot.org/uniprot/F7ICQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family. GDNF subfamily.|||Secreted http://togogenome.org/gene/9483:PTPRT ^@ http://purl.uniprot.org/uniprot/U3BNL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.|||Membrane http://togogenome.org/gene/9483:SOD2 ^@ http://purl.uniprot.org/uniprot/Q8HXP0 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-98 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting (By similarity).|||Belongs to the iron/manganese superoxide dismutase family.|||Binds 1 Mn(2+) ion per subunit.|||Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.|||Homotetramer.|||Mitochondrion matrix|||Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.|||Polyubiquitinated; leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability. http://togogenome.org/gene/9483:CDC26 ^@ http://purl.uniprot.org/uniprot/F7GVM0 ^@ Function|||Similarity ^@ Belongs to the CDC26 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. http://togogenome.org/gene/9483:MRPS31 ^@ http://purl.uniprot.org/uniprot/F7DHT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS31 family.|||Mitochondrion http://togogenome.org/gene/9483:METTL3 ^@ http://purl.uniprot.org/uniprot/U3CYA0 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/9483:SLC30A1 ^@ http://purl.uniprot.org/uniprot/U3CFK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9483:HMGCS1 ^@ http://purl.uniprot.org/uniprot/F6UT64 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family.|||Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. http://togogenome.org/gene/9483:RPL5 ^@ http://purl.uniprot.org/uniprot/F7BQL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL18 family.|||Cytoplasm http://togogenome.org/gene/9483:EIF4EBP1 ^@ http://purl.uniprot.org/uniprot/F6Y074 ^@ Similarity ^@ Belongs to the eIF4E-binding protein family. http://togogenome.org/gene/9483:PRPF19 ^@ http://purl.uniprot.org/uniprot/U3EI55 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat PRP19 family.|||Homotetramer.|||Lipid droplet|||Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.|||nucleoplasm http://togogenome.org/gene/9483:LOC100414558 ^@ http://purl.uniprot.org/uniprot/B0VXC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:ZZZ3 ^@ http://purl.uniprot.org/uniprot/A0A8I3WAU6|||http://purl.uniprot.org/uniprot/F6PXI2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:SLC41A2 ^@ http://purl.uniprot.org/uniprot/U3CH12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/9483:CCNB1 ^@ http://purl.uniprot.org/uniprot/F7I0H4 ^@ Function|||Similarity ^@ Belongs to the cyclin family.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition. http://togogenome.org/gene/9483:TLCD3A ^@ http://purl.uniprot.org/uniprot/F7IEA1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:OPN1SW ^@ http://purl.uniprot.org/uniprot/F7GQA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane|||Photoreceptor inner segment|||perinuclear region|||photoreceptor outer segment http://togogenome.org/gene/9483:LPAR1 ^@ http://purl.uniprot.org/uniprot/F6YCY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cell surface|||Endosome|||Membrane http://togogenome.org/gene/9483:TRAPPC13 ^@ http://purl.uniprot.org/uniprot/F7I5K4|||http://purl.uniprot.org/uniprot/U3D2J8|||http://purl.uniprot.org/uniprot/U3DQW9|||http://purl.uniprot.org/uniprot/U3FIZ7 ^@ Similarity|||Subunit ^@ Belongs to the TRAPPC13 family.|||Part of the multisubunit TRAPP (transport protein particle) complex. http://togogenome.org/gene/9483:CPA6 ^@ http://purl.uniprot.org/uniprot/A0A5F4WBP8 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9483:TMEM14A ^@ http://purl.uniprot.org/uniprot/U3DCF1 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/9483:SERPINB3 ^@ http://purl.uniprot.org/uniprot/B0CMA6 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9483:NNT ^@ http://purl.uniprot.org/uniprot/U3EPB3 ^@ Similarity ^@ In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/9483:PHKB ^@ http://purl.uniprot.org/uniprot/F7ABD1|||http://purl.uniprot.org/uniprot/U3BJS0|||http://purl.uniprot.org/uniprot/U3E3H5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphorylase b kinase regulatory chain family.|||Cell membrane|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.|||Membrane|||Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. http://togogenome.org/gene/9483:MNF1 ^@ http://purl.uniprot.org/uniprot/F6ZAL9 ^@ Subcellular Location Annotation ^@ mitochondrion nucleoid http://togogenome.org/gene/9483:WNT5A ^@ http://purl.uniprot.org/uniprot/F7I9H1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9483:ERH ^@ http://purl.uniprot.org/uniprot/F7ELJ3 ^@ Function|||Similarity ^@ Belongs to the E(R) family.|||May have a role in the cell cycle. http://togogenome.org/gene/9483:GNB3 ^@ http://purl.uniprot.org/uniprot/F6VBL9 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/9483:SMAD7 ^@ http://purl.uniprot.org/uniprot/U3D430 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:SSR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8M539|||http://purl.uniprot.org/uniprot/F7HEV2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-alpha family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.|||Membrane|||Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. http://togogenome.org/gene/9483:CNOT10 ^@ http://purl.uniprot.org/uniprot/A0A8I3WV29 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT10 family.|||Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:CERS3 ^@ http://purl.uniprot.org/uniprot/F7I7W6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9483:EFNB3 ^@ http://purl.uniprot.org/uniprot/U3E7W2 ^@ Caution|||Similarity ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:SEM1 ^@ http://purl.uniprot.org/uniprot/F7C1S5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DSS1/SEM1 family.|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.|||Nucleus http://togogenome.org/gene/9483:NHS ^@ http://purl.uniprot.org/uniprot/F7IAQ3 ^@ Similarity ^@ Belongs to the NHS family. http://togogenome.org/gene/9483:HAT1 ^@ http://purl.uniprot.org/uniprot/A0A8I4A0E4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HAT1 family.|||Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.|||Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac). http://togogenome.org/gene/9483:SLC35E3 ^@ http://purl.uniprot.org/uniprot/F7AVQ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:CD8A ^@ http://purl.uniprot.org/uniprot/Q3LRP5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9483:EML1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YH14 ^@ Similarity ^@ Belongs to the WD repeat EMAP family. http://togogenome.org/gene/9483:JPH4 ^@ http://purl.uniprot.org/uniprot/U3CU54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the junctophilin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.|||Membrane http://togogenome.org/gene/9483:OCM2 ^@ http://purl.uniprot.org/uniprot/F7B9H4 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/9483:NRP2 ^@ http://purl.uniprot.org/uniprot/U3D540|||http://purl.uniprot.org/uniprot/U3DFE5 ^@ Caution|||Similarity ^@ Belongs to the neuropilin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:MDFI ^@ http://purl.uniprot.org/uniprot/A0A8I3WUV7 ^@ Similarity ^@ Belongs to the MDFI family. http://togogenome.org/gene/9483:CRK ^@ http://purl.uniprot.org/uniprot/F7DT53 ^@ Similarity ^@ Belongs to the CRK family. http://togogenome.org/gene/9483:B4GALT3 ^@ http://purl.uniprot.org/uniprot/U3D0P7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9483:IER2 ^@ http://purl.uniprot.org/uniprot/F7IPF6 ^@ Similarity ^@ Belongs to the IER family. http://togogenome.org/gene/9483:CAMK4 ^@ http://purl.uniprot.org/uniprot/F7I122 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:TCF25 ^@ http://purl.uniprot.org/uniprot/F6R706|||http://purl.uniprot.org/uniprot/U3FVD4 ^@ Similarity ^@ Belongs to the TCF25 family. http://togogenome.org/gene/9483:PRKAR1B ^@ http://purl.uniprot.org/uniprot/U3ERD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:RPLP0 ^@ http://purl.uniprot.org/uniprot/F6WAG2 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL10 family.|||Ribosomal protein P0 is the functional equivalent of E.coli protein L10. http://togogenome.org/gene/9483:CWF19L1 ^@ http://purl.uniprot.org/uniprot/F7IRP5 ^@ Similarity ^@ Belongs to the CWF19 family. http://togogenome.org/gene/9483:CNEP1R1 ^@ http://purl.uniprot.org/uniprot/A0A8I3WNI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNEP1R1 family.|||Cytoplasm|||Membrane|||Nucleus membrane http://togogenome.org/gene/9483:GPM6A ^@ http://purl.uniprot.org/uniprot/F7EFH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/9483:WFDC5 ^@ http://purl.uniprot.org/uniprot/A4K2U0 ^@ Function|||Subcellular Location Annotation ^@ Putative acid-stable proteinase inhibitor.|||Secreted http://togogenome.org/gene/9483:CHRNB2 ^@ http://purl.uniprot.org/uniprot/F7HLC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9483:VPS13B ^@ http://purl.uniprot.org/uniprot/F7CGZ2|||http://purl.uniprot.org/uniprot/U3F2K7 ^@ Similarity ^@ Belongs to the VPS13 family. http://togogenome.org/gene/9483:LOC103793369 ^@ http://purl.uniprot.org/uniprot/A0A7R8C3E9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9483:PEX5 ^@ http://purl.uniprot.org/uniprot/U3CWR8|||http://purl.uniprot.org/uniprot/U3DKH6 ^@ Similarity ^@ Belongs to the peroxisomal targeting signal receptor family. http://togogenome.org/gene/9483:RNASE12 ^@ http://purl.uniprot.org/uniprot/W0UVB8 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9483:TM9SF4 ^@ http://purl.uniprot.org/uniprot/A0A8I3WG80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/9483:GSTO2 ^@ http://purl.uniprot.org/uniprot/A0A2R8MSP9|||http://purl.uniprot.org/uniprot/A0A7G3HPU4 ^@ Function|||Similarity ^@ Belongs to the GST superfamily. Omega family.|||Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). http://togogenome.org/gene/9483:EIF1AD ^@ http://purl.uniprot.org/uniprot/F7EAC3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the EIF1AD family.|||Interacts with GAPDH and STAT1.|||Plays a role into cellular response to oxidative stress. Decreases cell proliferation. http://togogenome.org/gene/9483:FGFBP1 ^@ http://purl.uniprot.org/uniprot/F7IHM9 ^@ Similarity ^@ Belongs to the fibroblast growth factor-binding protein family. http://togogenome.org/gene/9483:VIM ^@ http://purl.uniprot.org/uniprot/F7BQY8 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9483:KIF5C ^@ http://purl.uniprot.org/uniprot/U3EUR0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9483:FCER1G ^@ http://purl.uniprot.org/uniprot/F7I6E6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD3Z/FCER1G family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:INSIG2 ^@ http://purl.uniprot.org/uniprot/A0A5F4VWK9|||http://purl.uniprot.org/uniprot/B0CMA4|||http://purl.uniprot.org/uniprot/U3CHF3 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the INSIG family.|||Binds oxysterols in a pocket within their transmembrane domains and interacts with SCAP via transmembrane domains 3 and 4.|||Endoplasmic reticulum membrane|||Interacts with SCAP; interaction is direct and only takes place in the presence of sterols; it prevents interaction between SCAP and the coat protein complex II (COPII). Associates with the SCAP-SREBP complex (composed of SCAP and SREBF1/SREBP1 or SREBF2/SREBP2); association is mediated via its interaction with SCAP and only takes place in the presence of sterols. Interacts with RNF139. Interacts with RNF145.|||Mediates feedback control of cholesterol synthesis.|||Membrane|||Oxidized at Cys-215 in differentiated myotubes, preventing ubiquitination at the same site, and resulting in protein stabilization.|||Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR. Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum. In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi. Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG2 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2. Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase RNF139.|||Phosphorylation at Ser-151 by PCK1 reduces binding to oxysterol, disrupting the interaction between INSIG2 and SCAP, thereby promoting nuclear translocation of SREBP proteins (SREBF1/SREBP1 or SREBF2/SREBP2) and subsequent transcription of downstream lipogenesis-related genes.|||Polyubiquitinated by AMFR/gp78 at Cys-215 in some tissues such as adipose tissues, undifferentiated myoblasts and liver, leading to its degradation. In differentiated myotubes, Cys-215 oxidation prevents ubiquitination at the same site, resulting in protein stabilization.|||The KxHxx motif mediates association with the coatomer complex. http://togogenome.org/gene/9483:MNAT1 ^@ http://purl.uniprot.org/uniprot/F7I1L8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with CDK7 and cyclin H.|||Nucleus|||Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. http://togogenome.org/gene/9483:LOC100385683 ^@ http://purl.uniprot.org/uniprot/A0A2R8P0B6 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.|||Belongs to the universal ribosomal protein uS2 family.|||Cell membrane|||Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.|||Cytoplasm|||Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.|||Nucleus|||Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.|||This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. http://togogenome.org/gene/9483:SCAMP1 ^@ http://purl.uniprot.org/uniprot/F6TX27|||http://purl.uniprot.org/uniprot/F6U6N0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/9483:FOXO4 ^@ http://purl.uniprot.org/uniprot/U3E3C7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:NTNG1 ^@ http://purl.uniprot.org/uniprot/U3EJD3|||http://purl.uniprot.org/uniprot/U3EV01 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:MEF2B ^@ http://purl.uniprot.org/uniprot/U3F2R9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:HAGH ^@ http://purl.uniprot.org/uniprot/Q28333 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Sequence Caution|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ A mitochondrial longer isoform in the N-terminus has been proven to exist in orthologs.|||Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.|||Binds 2 Zn(2+) ions per subunit.|||Cloning artifact.|||Cytoplasm|||Mitochondrion matrix|||Monomer.|||Only one single gene encoding glyoxalase II has been identified in vertebrates. In yeast and higher plants, separate genes encode the cytosolic and mitochondrial forms of glyoxalase II.|||Testis.|||Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid. http://togogenome.org/gene/9483:ENPP1 ^@ http://purl.uniprot.org/uniprot/F7HLD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.|||Secreted http://togogenome.org/gene/9483:DNTT ^@ http://purl.uniprot.org/uniprot/F6RGZ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||Nucleus|||Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. http://togogenome.org/gene/9483:DEFB134 ^@ http://purl.uniprot.org/uniprot/A0A8I3WYR4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9483:NDUFB3 ^@ http://purl.uniprot.org/uniprot/F7HNF8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB3 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:CFAP206 ^@ http://purl.uniprot.org/uniprot/A0A8I3VYY0|||http://purl.uniprot.org/uniprot/A0A8I3WGX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP206 family.|||cilium axoneme http://togogenome.org/gene/9483:MUL1 ^@ http://purl.uniprot.org/uniprot/U3F761 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:FYN ^@ http://purl.uniprot.org/uniprot/F7IB43|||http://purl.uniprot.org/uniprot/U3BSY6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9483:NME1 ^@ http://purl.uniprot.org/uniprot/F6VUS6 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9483:CASP10 ^@ http://purl.uniprot.org/uniprot/U3CWK6 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9483:ISOC2 ^@ http://purl.uniprot.org/uniprot/U3BJN1 ^@ Similarity ^@ Belongs to the isochorismatase family. http://togogenome.org/gene/9483:ORMDL1 ^@ http://purl.uniprot.org/uniprot/F7FQP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/9483:HOXB8 ^@ http://purl.uniprot.org/uniprot/A0A2R8N4V1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:LOC100398205 ^@ http://purl.uniprot.org/uniprot/A0A2R8MUI6 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9483:PNLIPRP3 ^@ http://purl.uniprot.org/uniprot/A0A5F4WD72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9483:CCN1 ^@ http://purl.uniprot.org/uniprot/F7I1R4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9483:SEC61A1 ^@ http://purl.uniprot.org/uniprot/F7F6Y9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:RNF13 ^@ http://purl.uniprot.org/uniprot/F7HBJ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:PROKR1 ^@ http://purl.uniprot.org/uniprot/F7ISJ1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9483:NEUROD2 ^@ http://purl.uniprot.org/uniprot/F7ILB4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:IDS ^@ http://purl.uniprot.org/uniprot/F7EJG2 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9483:PIANP ^@ http://purl.uniprot.org/uniprot/A0A2R8MRS9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:SDC4 ^@ http://purl.uniprot.org/uniprot/A4K2U8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane http://togogenome.org/gene/9483:PLLP ^@ http://purl.uniprot.org/uniprot/F7H4F3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:HMOX2 ^@ http://purl.uniprot.org/uniprot/F7IJ83 ^@ Similarity ^@ Belongs to the heme oxygenase family. http://togogenome.org/gene/9483:HACD3 ^@ http://purl.uniprot.org/uniprot/A0A8I3W6C9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:MED31 ^@ http://purl.uniprot.org/uniprot/F7I0Q3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 31 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9483:SLC10A5 ^@ http://purl.uniprot.org/uniprot/F7HA47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/9483:SNCB ^@ http://purl.uniprot.org/uniprot/U3AQC0 ^@ Similarity ^@ Belongs to the synuclein family. http://togogenome.org/gene/9483:CNIH3 ^@ http://purl.uniprot.org/uniprot/F7HXG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/9483:BNIP1 ^@ http://purl.uniprot.org/uniprot/F7HD41 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:LGI3 ^@ http://purl.uniprot.org/uniprot/U3F159 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9483:TPM1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XPA2|||http://purl.uniprot.org/uniprot/A0A8J8YJA3|||http://purl.uniprot.org/uniprot/F6YS84|||http://purl.uniprot.org/uniprot/U3FTU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9483:IFT20 ^@ http://purl.uniprot.org/uniprot/A0A2R8MRU5 ^@ Subcellular Location Annotation ^@ centriole|||cilium|||cis-Golgi network http://togogenome.org/gene/9483:IL5 ^@ http://purl.uniprot.org/uniprot/Q0Z974 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-5 family.|||Homodimer; disulfide-linked.|||Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively.|||Secreted http://togogenome.org/gene/9483:SPA17 ^@ http://purl.uniprot.org/uniprot/Q9XT29 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates. http://togogenome.org/gene/9483:AVL9 ^@ http://purl.uniprot.org/uniprot/A0A8J8YF10|||http://purl.uniprot.org/uniprot/U3D6Q3 ^@ Subcellular Location Annotation ^@ Recycling endosome http://togogenome.org/gene/9483:SRPX ^@ http://purl.uniprot.org/uniprot/U3BB10|||http://purl.uniprot.org/uniprot/U3CBQ0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:CLDN11 ^@ http://purl.uniprot.org/uniprot/F6Y431 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9483:LHCGR ^@ http://purl.uniprot.org/uniprot/O02721 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.|||Sulfated. http://togogenome.org/gene/9483:NKAIN2 ^@ http://purl.uniprot.org/uniprot/U3C7Z8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NKAIN family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:CLPS ^@ http://purl.uniprot.org/uniprot/F7HYJ9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.|||Enterostatin has a biological activity as a satiety signal.|||Forms a 1:1 stoichiometric complex with pancreatic lipase.|||Secreted http://togogenome.org/gene/9483:SLC25A25 ^@ http://purl.uniprot.org/uniprot/A0A5K1TZ61|||http://purl.uniprot.org/uniprot/F6YJ93|||http://purl.uniprot.org/uniprot/F6YJA1|||http://purl.uniprot.org/uniprot/U3E298|||http://purl.uniprot.org/uniprot/U3FRM1|||http://purl.uniprot.org/uniprot/U3FVU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9483:NEMF ^@ http://purl.uniprot.org/uniprot/U3CHM6 ^@ Similarity ^@ Belongs to the NEMF family. http://togogenome.org/gene/9483:CCNL2 ^@ http://purl.uniprot.org/uniprot/F7FXM5 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9483:SLC25A39 ^@ http://purl.uniprot.org/uniprot/F6VZN0|||http://purl.uniprot.org/uniprot/U3DW85 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:NDP ^@ http://purl.uniprot.org/uniprot/U3EC42 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9483:GTPBP3 ^@ http://purl.uniprot.org/uniprot/F6YWZ5 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. http://togogenome.org/gene/9483:SFXN1 ^@ http://purl.uniprot.org/uniprot/F7F6B4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9483:TRIM4 ^@ http://purl.uniprot.org/uniprot/F6UD69|||http://purl.uniprot.org/uniprot/F7CQC7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRIM/RBCC family.|||Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:NUF2 ^@ http://purl.uniprot.org/uniprot/F6PHA6 ^@ Similarity ^@ Belongs to the NUF2 family. http://togogenome.org/gene/9483:LPAR6 ^@ http://purl.uniprot.org/uniprot/U3BLR3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9483:SLC44A2 ^@ http://purl.uniprot.org/uniprot/U3EU51 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/9483:RGS7BP ^@ http://purl.uniprot.org/uniprot/F6XC06 ^@ Similarity ^@ Belongs to the RGS7BP/RGS9BP family. http://togogenome.org/gene/9483:COPS4 ^@ http://purl.uniprot.org/uniprot/U3FN66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN4 family.|||Nucleus|||Vesicle|||synaptic vesicle http://togogenome.org/gene/9483:DOP1A ^@ http://purl.uniprot.org/uniprot/U3F9R1 ^@ Similarity ^@ Belongs to the dopey family. http://togogenome.org/gene/9483:PTOV1 ^@ http://purl.uniprot.org/uniprot/F6T3A6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activates transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation.|||Belongs to the Mediator complex subunit 25 family. PTOV1 subfamily.|||Cell membrane|||Cytoplasm|||May interact with CREBBP. Interacts with FLOT1.|||Nucleus|||perinuclear region http://togogenome.org/gene/9483:PSIP1 ^@ http://purl.uniprot.org/uniprot/F7IFC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HDGF family.|||Nucleus http://togogenome.org/gene/9483:LOC100393797 ^@ http://purl.uniprot.org/uniprot/F7IJU8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/9483:RIOK1 ^@ http://purl.uniprot.org/uniprot/F7G1T7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/9483:LOC100401354 ^@ http://purl.uniprot.org/uniprot/F6ZYH3 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9483:ADGRG1 ^@ http://purl.uniprot.org/uniprot/U3C7R1|||http://purl.uniprot.org/uniprot/U3EUN1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Membrane raft|||Secreted http://togogenome.org/gene/9483:AR ^@ http://purl.uniprot.org/uniprot/F7GJ39 ^@ Similarity ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily. http://togogenome.org/gene/9483:TMOD4 ^@ http://purl.uniprot.org/uniprot/B0KWB6 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9483:TNFSF12 ^@ http://purl.uniprot.org/uniprot/F7FJI7 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9483:PDHA1 ^@ http://purl.uniprot.org/uniprot/U3FGT0 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. http://togogenome.org/gene/9483:TFCP2L1 ^@ http://purl.uniprot.org/uniprot/F7G0J7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus http://togogenome.org/gene/9483:HASPIN ^@ http://purl.uniprot.org/uniprot/F7GU79 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/9483:UNC13B ^@ http://purl.uniprot.org/uniprot/U3CPW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-13 family.|||Cytoplasm|||Membrane http://togogenome.org/gene/9483:NUP58 ^@ http://purl.uniprot.org/uniprot/U3EP89 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/9483:GALR1 ^@ http://purl.uniprot.org/uniprot/A0A8I3WUP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9483:GLYCTK ^@ http://purl.uniprot.org/uniprot/F7IB83 ^@ Similarity ^@ Belongs to the glycerate kinase type-2 family. http://togogenome.org/gene/9483:ORMDL3 ^@ http://purl.uniprot.org/uniprot/F7H4F1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/9483:LOC100389781 ^@ http://purl.uniprot.org/uniprot/U3DFP9 ^@ Function|||Subunit ^@ Interacts with CD4. Interacts with ALDH16A1.|||May play a role as a negative regulatory factor in CD4-dependent T-cell activation. http://togogenome.org/gene/9483:LOC100414863 ^@ http://purl.uniprot.org/uniprot/F7FBY9 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9483:DTYMK ^@ http://purl.uniprot.org/uniprot/F7ED91 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/9483:VWC2L ^@ http://purl.uniprot.org/uniprot/F6TJC5 ^@ Subcellular Location Annotation ^@ Synapse http://togogenome.org/gene/9483:LOC100407125 ^@ http://purl.uniprot.org/uniprot/F6U3I8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-defensin family.|||Secreted http://togogenome.org/gene/9483:IL2RA ^@ http://purl.uniprot.org/uniprot/Q19LH5 ^@ Caution|||Function|||Subunit ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.|||Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. http://togogenome.org/gene/9483:XCR1 ^@ http://purl.uniprot.org/uniprot/F7HJW0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9483:DUSP1 ^@ http://purl.uniprot.org/uniprot/U3FNS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/9483:CPPED1 ^@ http://purl.uniprot.org/uniprot/F7HL73 ^@ Function|||Similarity ^@ Belongs to the metallophosphoesterase superfamily. CPPED1 family.|||Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes. http://togogenome.org/gene/9483:GORASP2 ^@ http://purl.uniprot.org/uniprot/F6Z4V2 ^@ Similarity ^@ Belongs to the GORASP family. http://togogenome.org/gene/9483:KCNMB1 ^@ http://purl.uniprot.org/uniprot/F6R0K0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KCNMB (TC 8.A.14.1) family.|||Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.|||Membrane|||N-glycosylated.|||Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. http://togogenome.org/gene/9483:TGIF2 ^@ http://purl.uniprot.org/uniprot/F7IBT3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:GDF2 ^@ http://purl.uniprot.org/uniprot/F6UYA9 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9483:EPHA1 ^@ http://purl.uniprot.org/uniprot/F7I7A7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:EAF2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YCI6 ^@ Similarity ^@ Belongs to the EAF family. http://togogenome.org/gene/9483:UMPS ^@ http://purl.uniprot.org/uniprot/U3E3B4 ^@ Similarity ^@ In the C-terminal section; belongs to the OMP decarboxylase family.|||In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/9483:EVL ^@ http://purl.uniprot.org/uniprot/A0A8J8YCD3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Ena/VASP family.|||Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.|||cytoskeleton http://togogenome.org/gene/9483:ENY2 ^@ http://purl.uniprot.org/uniprot/U3FW45 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ENY2 family.|||Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.|||Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.|||nucleoplasm http://togogenome.org/gene/9483:UNC5A ^@ http://purl.uniprot.org/uniprot/F6ZXV4|||http://purl.uniprot.org/uniprot/U3FSB7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-5 family.|||Cell membrane|||Membrane|||Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. http://togogenome.org/gene/9483:HSPA4L ^@ http://purl.uniprot.org/uniprot/U3B6H3 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9483:TMEM230 ^@ http://purl.uniprot.org/uniprot/F6UFQ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM134/TMEM230 family.|||Early endosome|||Endosome|||Involved in trafficking and recycling of synaptic vesicles.|||Late endosome|||Membrane|||Recycling endosome|||autophagosome|||synaptic vesicle|||trans-Golgi network http://togogenome.org/gene/9483:HSD17B3 ^@ http://purl.uniprot.org/uniprot/A0A8I3W2T7 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9483:SKA2 ^@ http://purl.uniprot.org/uniprot/U3DQH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SKA2 family.|||spindle http://togogenome.org/gene/9483:SUSD4 ^@ http://purl.uniprot.org/uniprot/U3DA72 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:SESN3 ^@ http://purl.uniprot.org/uniprot/F6T2D9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/9483:DKK2 ^@ http://purl.uniprot.org/uniprot/A0A5F4WB29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/9483:GDPD1 ^@ http://purl.uniprot.org/uniprot/A0A5F4WCD7 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9483:SSBP3 ^@ http://purl.uniprot.org/uniprot/F7HIR6|||http://purl.uniprot.org/uniprot/F7IAZ3|||http://purl.uniprot.org/uniprot/U3FUU1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:FGF9 ^@ http://purl.uniprot.org/uniprot/F7I3P1 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9483:RPS27L ^@ http://purl.uniprot.org/uniprot/F7HWT8 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9483:FOXP3 ^@ http://purl.uniprot.org/uniprot/C7EPD6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:LOC100400370 ^@ http://purl.uniprot.org/uniprot/A0A2R8MU46 ^@ Caution|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.|||Belongs to the universal ribosomal protein uS2 family.|||Cell membrane|||Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.|||Nucleus|||Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.|||This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. http://togogenome.org/gene/9483:SGTB ^@ http://purl.uniprot.org/uniprot/F7I0S4 ^@ Similarity ^@ Belongs to the SGT family. http://togogenome.org/gene/9483:SUCLG2 ^@ http://purl.uniprot.org/uniprot/U3EK93 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.|||Binds 1 Mg(2+) ion per subunit.|||GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.|||Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.|||Mitochondrion http://togogenome.org/gene/9483:PPM1G ^@ http://purl.uniprot.org/uniprot/F7BFT9 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9483:GLRA4 ^@ http://purl.uniprot.org/uniprot/F6QEB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/9483:TNKS2 ^@ http://purl.uniprot.org/uniprot/U3C2N9 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9483:LOC100388732 ^@ http://purl.uniprot.org/uniprot/B0VXB5|||http://purl.uniprot.org/uniprot/Q9GJS7 ^@ Function|||Similarity|||Subunit|||Tissue Specificity ^@ Belongs to the globin family.|||Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.|||Heterotetramer of two alpha chains and two gamma chains in fetal hemoglobin (Hb F).|||Red blood cells. http://togogenome.org/gene/9483:ADSL ^@ http://purl.uniprot.org/uniprot/U3EF93 ^@ Function|||Similarity|||Subunit ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.|||Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site. http://togogenome.org/gene/9483:HDAC10 ^@ http://purl.uniprot.org/uniprot/U3FQ71 ^@ Similarity ^@ Belongs to the histone deacetylase family. HD type 2 subfamily. http://togogenome.org/gene/9483:BICD1 ^@ http://purl.uniprot.org/uniprot/A0A8I3WHB3|||http://purl.uniprot.org/uniprot/F6Q1B3|||http://purl.uniprot.org/uniprot/F6QBM4 ^@ Similarity ^@ Belongs to the BicD family. http://togogenome.org/gene/9483:XKR5 ^@ http://purl.uniprot.org/uniprot/F6PU51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9483:LOC100390933 ^@ http://purl.uniprot.org/uniprot/F7B755 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX17 family.|||Mitochondrion intermembrane space http://togogenome.org/gene/9483:HS3ST5 ^@ http://purl.uniprot.org/uniprot/A0A8I4A0Y7 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9483:TENT5C ^@ http://purl.uniprot.org/uniprot/U3BX57 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/9483:MAB21L1 ^@ http://purl.uniprot.org/uniprot/F7DWX9 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9483:RARS2 ^@ http://purl.uniprot.org/uniprot/F6Z0R1|||http://purl.uniprot.org/uniprot/U3BS49 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9483:PRIM2 ^@ http://purl.uniprot.org/uniprot/U3BC63 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the eukaryotic-type primase large subunit family.|||Binds 1 [4Fe-4S] cluster.|||Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. http://togogenome.org/gene/9483:LOC100413569 ^@ http://purl.uniprot.org/uniprot/A0A8I3XB20 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9483:SEPTIN2 ^@ http://purl.uniprot.org/uniprot/U3FNX7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cleavage furrow|||Filament-forming cytoskeletal GTPase.|||Midbody|||Septins polymerize into heterooligomeric protein complexes that form filaments.|||cilium membrane|||flagellum|||spindle http://togogenome.org/gene/9483:MORF4L1 ^@ http://purl.uniprot.org/uniprot/A0A5F4VST9|||http://purl.uniprot.org/uniprot/U3F3Z8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:LOC100390201 ^@ http://purl.uniprot.org/uniprot/A0A2R8MXF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9483:GRP ^@ http://purl.uniprot.org/uniprot/F7DIJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bombesin/neuromedin-B/ranatensin family.|||Secreted|||neuron projection http://togogenome.org/gene/9483:GRIA3 ^@ http://purl.uniprot.org/uniprot/F7IP00 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9483:SMG7 ^@ http://purl.uniprot.org/uniprot/U3BG63|||http://purl.uniprot.org/uniprot/U3BZ42 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Plays a role in nonsense-mediated mRNA decay. http://togogenome.org/gene/9483:CLN8 ^@ http://purl.uniprot.org/uniprot/F7I8I0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:GHRH ^@ http://purl.uniprot.org/uniprot/A0A8I3W2I3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/9483:MYH1 ^@ http://purl.uniprot.org/uniprot/F7FKN4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9483:GPR34 ^@ http://purl.uniprot.org/uniprot/Q6XCG2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Orphan receptor. http://togogenome.org/gene/9483:NEMP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8MN53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NEMP family.|||Nucleus inner membrane http://togogenome.org/gene/9483:HMGA1 ^@ http://purl.uniprot.org/uniprot/F7HUN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGA family.|||Nucleus http://togogenome.org/gene/9483:NGRN ^@ http://purl.uniprot.org/uniprot/F6Z313 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the neugrin family.|||Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct.|||Mitochondrion membrane|||Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system. http://togogenome.org/gene/9483:CFLAR ^@ http://purl.uniprot.org/uniprot/F7IMN8 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9483:CIAO2A ^@ http://purl.uniprot.org/uniprot/A0A8I3WYR8|||http://purl.uniprot.org/uniprot/F7IHH5 ^@ Similarity ^@ Belongs to the MIP18 family. http://togogenome.org/gene/9483:SLU7 ^@ http://purl.uniprot.org/uniprot/U3DZ06 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the SLU7 family.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/9483:TXLNA ^@ http://purl.uniprot.org/uniprot/F7EWF4 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/9483:TSPAN11 ^@ http://purl.uniprot.org/uniprot/U3DFF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9483:SGCE ^@ http://purl.uniprot.org/uniprot/A0A5K1U701|||http://purl.uniprot.org/uniprot/F6SLC1|||http://purl.uniprot.org/uniprot/U3D1I1|||http://purl.uniprot.org/uniprot/U3ET27 ^@ Function|||Similarity ^@ Belongs to the sarcoglycan alpha/epsilon family.|||Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. http://togogenome.org/gene/9483:GNB2 ^@ http://purl.uniprot.org/uniprot/U3F085 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/9483:SF3B6 ^@ http://purl.uniprot.org/uniprot/U3EW04 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:NAA38 ^@ http://purl.uniprot.org/uniprot/F7DEN2 ^@ Function|||Similarity|||Subunit ^@ Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.|||Belongs to the snRNP Sm proteins family.|||Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30. http://togogenome.org/gene/9483:TRMT11 ^@ http://purl.uniprot.org/uniprot/U3FI61 ^@ Function|||Subunit ^@ Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.|||Interacts with TRMT112. http://togogenome.org/gene/9483:VANGL1 ^@ http://purl.uniprot.org/uniprot/U3D5G8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Vang family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:CCS ^@ http://purl.uniprot.org/uniprot/D2KTC2 ^@ Similarity ^@ In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family. http://togogenome.org/gene/9483:GNA12 ^@ http://purl.uniprot.org/uniprot/F7HMM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-alpha family. G(12) subfamily.|||Membrane http://togogenome.org/gene/9483:SMUG1 ^@ http://purl.uniprot.org/uniprot/F7I3E8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.|||Nucleus http://togogenome.org/gene/9483:DDAH1 ^@ http://purl.uniprot.org/uniprot/F7B3R1 ^@ Function|||Similarity ^@ Belongs to the DDAH family.|||Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. http://togogenome.org/gene/9483:PIGK ^@ http://purl.uniprot.org/uniprot/U3BHU8 ^@ Similarity|||Subunit ^@ Belongs to the peptidase C13 family.|||Forms a complex with PIGT, PIGS, PIGU and GAA1. http://togogenome.org/gene/9483:DRD5 ^@ http://purl.uniprot.org/uniprot/F6UEN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:FGF14 ^@ http://purl.uniprot.org/uniprot/A0A2R8PC64|||http://purl.uniprot.org/uniprot/U3FT30 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9483:CDH19 ^@ http://purl.uniprot.org/uniprot/F7IA45 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:PCSK1 ^@ http://purl.uniprot.org/uniprot/U3F9M2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S8 family.|||Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.|||Vesicle|||secretory vesicle http://togogenome.org/gene/9483:LOC100395489 ^@ http://purl.uniprot.org/uniprot/A0A8I3WPU1 ^@ Similarity ^@ Belongs to the pro/parathymosin family. http://togogenome.org/gene/9483:CARMIL3 ^@ http://purl.uniprot.org/uniprot/F7BFA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CARMIL family.|||Cytoplasm http://togogenome.org/gene/9483:TMBIM6 ^@ http://purl.uniprot.org/uniprot/A0A2R8MGV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9483:SUPV3L1 ^@ http://purl.uniprot.org/uniprot/F7FZQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family.|||mitochondrion nucleoid http://togogenome.org/gene/9483:MBOAT2 ^@ http://purl.uniprot.org/uniprot/U3C8F4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:LIMS1 ^@ http://purl.uniprot.org/uniprot/F7BUC0|||http://purl.uniprot.org/uniprot/U3B8D6|||http://purl.uniprot.org/uniprot/U3E3I9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.|||Cell membrane|||Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.|||focal adhesion http://togogenome.org/gene/9483:CLDN14 ^@ http://purl.uniprot.org/uniprot/F7C3D9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9483:MRPL18 ^@ http://purl.uniprot.org/uniprot/F6T3Q3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL18 family. http://togogenome.org/gene/9483:SAMD8 ^@ http://purl.uniprot.org/uniprot/U3EKZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/9483:LOC100406470 ^@ http://purl.uniprot.org/uniprot/H9KXU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:ADGRL2 ^@ http://purl.uniprot.org/uniprot/U3FSP2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:TMEM242 ^@ http://purl.uniprot.org/uniprot/F7G9P5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM242 family.|||Membrane http://togogenome.org/gene/9483:GABRA5 ^@ http://purl.uniprot.org/uniprot/U3C1H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9483:MEF2A ^@ http://purl.uniprot.org/uniprot/F7HSJ6|||http://purl.uniprot.org/uniprot/U3DEP8|||http://purl.uniprot.org/uniprot/U3EXX2|||http://purl.uniprot.org/uniprot/U3F6J9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:SNRNP27 ^@ http://purl.uniprot.org/uniprot/F7F836 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNUT3 family.|||May play a role in mRNA splicing.|||Nucleus|||Part of a tri-snRNP complex. http://togogenome.org/gene/9483:VAT1L ^@ http://purl.uniprot.org/uniprot/U3FTD7 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/9483:UPF3A ^@ http://purl.uniprot.org/uniprot/F7IFT2 ^@ Similarity ^@ Belongs to the RENT3 family. http://togogenome.org/gene/9483:GCSH ^@ http://purl.uniprot.org/uniprot/U3CM87 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||Mitochondrion|||The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/9483:LOC103796754 ^@ http://purl.uniprot.org/uniprot/A0A8I3W2H5 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion membrane http://togogenome.org/gene/9483:TRPT1 ^@ http://purl.uniprot.org/uniprot/U3CEU2 ^@ Function|||Similarity ^@ Belongs to the KptA/TPT1 family.|||Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate. http://togogenome.org/gene/9483:LEAP2 ^@ http://purl.uniprot.org/uniprot/B0KWP9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LEAP2 family.|||Has an antimicrobial activity.|||Secreted http://togogenome.org/gene/9483:FKRP ^@ http://purl.uniprot.org/uniprot/F6TG30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LicD transferase family.|||Golgi apparatus membrane http://togogenome.org/gene/9483:METTL26 ^@ http://purl.uniprot.org/uniprot/F6T1P9|||http://purl.uniprot.org/uniprot/F7C369 ^@ Similarity ^@ Belongs to the UPF0585 family. http://togogenome.org/gene/9483:LOC100411835 ^@ http://purl.uniprot.org/uniprot/A0A8I4A167 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/9483:PDE7A ^@ http://purl.uniprot.org/uniprot/F7IHC1|||http://purl.uniprot.org/uniprot/F7IJN4 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9483:CAMK2D ^@ http://purl.uniprot.org/uniprot/A0A2R8M8I7|||http://purl.uniprot.org/uniprot/A0A2R8MP59|||http://purl.uniprot.org/uniprot/A0A2R8PG23 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9483:SLC25A26 ^@ http://purl.uniprot.org/uniprot/F6UCJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9483:ABL1 ^@ http://purl.uniprot.org/uniprot/U3BH45 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9483:SLC45A3 ^@ http://purl.uniprot.org/uniprot/A0A2R8MSZ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:ARTN ^@ http://purl.uniprot.org/uniprot/F6PVA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family. GDNF subfamily.|||Secreted http://togogenome.org/gene/9483:RPS26 ^@ http://purl.uniprot.org/uniprot/A0A2R8MZE0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS26 family. http://togogenome.org/gene/9483:PARP2 ^@ http://purl.uniprot.org/uniprot/F7FIN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARTD/PARP family.|||Nucleus http://togogenome.org/gene/9483:NDUFC1 ^@ http://purl.uniprot.org/uniprot/F7IC73 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFC1 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:MRPS25 ^@ http://purl.uniprot.org/uniprot/F7HYE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS25 family.|||Mitochondrion http://togogenome.org/gene/9483:DTNB ^@ http://purl.uniprot.org/uniprot/F7GZQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dystrophin family. Dystrobrevin subfamily.|||Cytoplasm http://togogenome.org/gene/9483:THUMPD2 ^@ http://purl.uniprot.org/uniprot/A0A5F4W7R1|||http://purl.uniprot.org/uniprot/F7G5B3 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/9483:SLITRK2 ^@ http://purl.uniprot.org/uniprot/F7IN27 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9483:STMN2 ^@ http://purl.uniprot.org/uniprot/U3EIE6 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/9483:RRM1 ^@ http://purl.uniprot.org/uniprot/F6ZKF5 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/9483:HBM ^@ http://purl.uniprot.org/uniprot/B0VX77 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9483:MYOC ^@ http://purl.uniprot.org/uniprot/A0A8I3XF71 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:SPATS2L ^@ http://purl.uniprot.org/uniprot/A0A8I3WA21|||http://purl.uniprot.org/uniprot/U3DH00|||http://purl.uniprot.org/uniprot/U3ENF9 ^@ Similarity ^@ Belongs to the SPATS2 family. http://togogenome.org/gene/9483:MARF1 ^@ http://purl.uniprot.org/uniprot/U3F7E5 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/9483:NR2F2 ^@ http://purl.uniprot.org/uniprot/F7ICX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9483:HSDL2 ^@ http://purl.uniprot.org/uniprot/U3FND2 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/9483:SCO1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y5X2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCO1/2 family.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:NOL12 ^@ http://purl.uniprot.org/uniprot/U3D4W1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRP17 family.|||Interacts with KIAA1191.|||nucleolus http://togogenome.org/gene/9483:XRCC5 ^@ http://purl.uniprot.org/uniprot/U3E6P1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ku80 family.|||Nucleus|||Single-stranded DNA-dependent ATP-dependent helicase. http://togogenome.org/gene/9483:PTPN2 ^@ http://purl.uniprot.org/uniprot/U3DFJ3|||http://purl.uniprot.org/uniprot/U3FTG6 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. http://togogenome.org/gene/9483:POMGNT1 ^@ http://purl.uniprot.org/uniprot/U3BTL9 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 13 family.|||Golgi apparatus membrane|||Membrane|||Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.|||The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.|||The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein. http://togogenome.org/gene/9483:WRNIP1 ^@ http://purl.uniprot.org/uniprot/F7D6S4 ^@ Similarity ^@ Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily. http://togogenome.org/gene/9483:SQLE ^@ http://purl.uniprot.org/uniprot/F7HNP5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the squalene monooxygenase family.|||Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9483:MRPL30 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZK6|||http://purl.uniprot.org/uniprot/U3D6P9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/9483:VPS26C ^@ http://purl.uniprot.org/uniprot/F7ALR6|||http://purl.uniprot.org/uniprot/F7ALS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS26 family.|||Endosome http://togogenome.org/gene/9483:SHKBP1 ^@ http://purl.uniprot.org/uniprot/F7G6M1 ^@ Similarity ^@ Belongs to the KCTD3 family. http://togogenome.org/gene/9483:LOC100414961 ^@ http://purl.uniprot.org/uniprot/A0A2R8MYK0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9483:TMEM106A ^@ http://purl.uniprot.org/uniprot/F7I1J6 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/9483:MOCS3 ^@ http://purl.uniprot.org/uniprot/F7GUM3 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds 1 zinc ion per subunit.|||Cytoplasm|||In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.|||Interacts with NFS1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions. http://togogenome.org/gene/9483:OR6N2 ^@ http://purl.uniprot.org/uniprot/F7HXL5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:ISCU ^@ http://purl.uniprot.org/uniprot/U3DV20 ^@ Function|||Similarity ^@ Belongs to the NifU family.|||Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5. Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form. May modulate NFS1 desulfurase activity in a zinc-dependent manner. Modulates the interaction between FXN and the cysteine desulfurase complex. http://togogenome.org/gene/9483:ATP1A3 ^@ http://purl.uniprot.org/uniprot/A0A8I4A1P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:CPT2 ^@ http://purl.uniprot.org/uniprot/F7IPZ3 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/9483:CMPK2 ^@ http://purl.uniprot.org/uniprot/A0A8I3WJ17 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/9483:SLC26A1 ^@ http://purl.uniprot.org/uniprot/F7EMH5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane|||Sodium-independent sulfate anion transporter. Can transport other anions including bicarbonate, thiosulfate and oxalate. http://togogenome.org/gene/9483:NKX2-8 ^@ http://purl.uniprot.org/uniprot/A0A2R8MHW5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:BBS7 ^@ http://purl.uniprot.org/uniprot/U3EBP5 ^@ Function|||Subunit ^@ Part of BBSome complex.|||The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. http://togogenome.org/gene/9483:CCT5 ^@ http://purl.uniprot.org/uniprot/F6Y1Q5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9483:COPS6 ^@ http://purl.uniprot.org/uniprot/F6XZK7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M67A family. CSN6 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:ELP6 ^@ http://purl.uniprot.org/uniprot/A0A8J8YT58 ^@ Similarity ^@ Belongs to the ELP6 family. http://togogenome.org/gene/9483:KDM1A ^@ http://purl.uniprot.org/uniprot/F7HZ54|||http://purl.uniprot.org/uniprot/U3BZN3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the flavin monoamine oxidase family.|||Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity.|||Nucleus|||The SWIRM domain may act as an anchor site for a histone tail. http://togogenome.org/gene/9483:LOC100391740 ^@ http://purl.uniprot.org/uniprot/B0VX98 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:RGS2 ^@ http://purl.uniprot.org/uniprot/F7HJN9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||nucleolus http://togogenome.org/gene/9483:OR2T11 ^@ http://purl.uniprot.org/uniprot/F7HDZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:FLI1 ^@ http://purl.uniprot.org/uniprot/U3BDK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9483:SLC7A14 ^@ http://purl.uniprot.org/uniprot/F6W919 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:LOC100396744 ^@ http://purl.uniprot.org/uniprot/U3CM30 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9483:EYA2 ^@ http://purl.uniprot.org/uniprot/F7HWD0|||http://purl.uniprot.org/uniprot/U3ECE7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/9483:HOXB13 ^@ http://purl.uniprot.org/uniprot/F7BWB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9483:GASK1B ^@ http://purl.uniprot.org/uniprot/A0A5K1U419 ^@ Similarity ^@ Belongs to the GASK family. http://togogenome.org/gene/9483:FA2H ^@ http://purl.uniprot.org/uniprot/F7I985 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sterol desaturase family. SCS7 subfamily.|||Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.|||Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:SLCO3A1 ^@ http://purl.uniprot.org/uniprot/F7IEX0|||http://purl.uniprot.org/uniprot/U3DDR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:TMEM170B ^@ http://purl.uniprot.org/uniprot/U3F5M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM170 family.|||Membrane http://togogenome.org/gene/9483:BMP7 ^@ http://purl.uniprot.org/uniprot/U3CV29 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9483:AMD1 ^@ http://purl.uniprot.org/uniprot/U3DMU3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic AdoMetDC family.|||Binds 1 pyruvoyl group covalently per subunit.|||Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.|||Heterotetramer of two alpha and two beta chains. http://togogenome.org/gene/9483:RTRAF ^@ http://purl.uniprot.org/uniprot/U3DVX0|||http://purl.uniprot.org/uniprot/U3EBH0 ^@ Similarity ^@ Belongs to the RTRAF family. http://togogenome.org/gene/9483:CCL22 ^@ http://purl.uniprot.org/uniprot/A0A8I3WKT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9483:CPVL ^@ http://purl.uniprot.org/uniprot/F7GPF2 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/9483:PKD2 ^@ http://purl.uniprot.org/uniprot/A0A5F4W9Q9|||http://purl.uniprot.org/uniprot/U3F411 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the polycystin family.|||Cell membrane|||Membrane|||cilium membrane http://togogenome.org/gene/9483:SS18 ^@ http://purl.uniprot.org/uniprot/U3CMU6|||http://purl.uniprot.org/uniprot/U3FL36 ^@ Similarity ^@ Belongs to the SS18 family. http://togogenome.org/gene/9483:SMARCAD1 ^@ http://purl.uniprot.org/uniprot/A0A5K1UF91 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/9483:SLC13A4 ^@ http://purl.uniprot.org/uniprot/U3E7C7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/9483:NKIRAS1 ^@ http://purl.uniprot.org/uniprot/F7H5N4 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. http://togogenome.org/gene/9483:SNX32 ^@ http://purl.uniprot.org/uniprot/F7F0Y1 ^@ Function|||Similarity ^@ Belongs to the sorting nexin family.|||Involved in several stages of intracellular trafficking. http://togogenome.org/gene/9483:KIF2A ^@ http://purl.uniprot.org/uniprot/A0A2R8MFK6|||http://purl.uniprot.org/uniprot/U3BC72|||http://purl.uniprot.org/uniprot/U3DRA9 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9483:SULT1B1 ^@ http://purl.uniprot.org/uniprot/A0A7G3QNV8 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9483:MOB2 ^@ http://purl.uniprot.org/uniprot/U3CXE9 ^@ Similarity ^@ Belongs to the MOB1/phocein family. http://togogenome.org/gene/9483:GPSM2 ^@ http://purl.uniprot.org/uniprot/U3D953 ^@ Similarity ^@ Belongs to the GPSM family. http://togogenome.org/gene/9483:HMCES ^@ http://purl.uniprot.org/uniprot/F7H7D8 ^@ Function|||Similarity ^@ Belongs to the SOS response-associated peptidase family.|||Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction. http://togogenome.org/gene/9483:PTGES3 ^@ http://purl.uniprot.org/uniprot/A0A2R8MSN2|||http://purl.uniprot.org/uniprot/F7CND0|||http://purl.uniprot.org/uniprot/U3BK01 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the p23/wos2 family.|||Cytoplasm|||Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation.|||Forms a complex with HSP70, HSP90 and other chaperones. http://togogenome.org/gene/9483:INTS7 ^@ http://purl.uniprot.org/uniprot/U3AS40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 7 family.|||Nucleus http://togogenome.org/gene/9483:BTG3 ^@ http://purl.uniprot.org/uniprot/F7H6J9 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9483:CCNQ ^@ http://purl.uniprot.org/uniprot/A0A8J8XV73|||http://purl.uniprot.org/uniprot/F7GVF7 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin-like FAM58 subfamily. http://togogenome.org/gene/9483:CDK14 ^@ http://purl.uniprot.org/uniprot/A0A2R8MEH5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:CORT ^@ http://purl.uniprot.org/uniprot/F7I1I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatostatin family.|||Secreted http://togogenome.org/gene/9483:DMRTA2 ^@ http://purl.uniprot.org/uniprot/A0A2R8MD45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/9483:PFKFB2 ^@ http://purl.uniprot.org/uniprot/A0A8I3X071|||http://purl.uniprot.org/uniprot/F6VUU1 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/9483:PPIB ^@ http://purl.uniprot.org/uniprot/F7ISM3 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9483:DNAJC10 ^@ http://purl.uniprot.org/uniprot/A0A5F4VYX5 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9483:GALNT4 ^@ http://purl.uniprot.org/uniprot/U3BW57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:B4GALNT2 ^@ http://purl.uniprot.org/uniprot/F6ZYQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family.|||Membrane http://togogenome.org/gene/9483:NPL ^@ http://purl.uniprot.org/uniprot/U3D488 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family. NanA subfamily.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/9483:PREPL ^@ http://purl.uniprot.org/uniprot/F7HE24|||http://purl.uniprot.org/uniprot/U3BKQ0 ^@ Similarity ^@ Belongs to the peptidase S9A family. http://togogenome.org/gene/9483:OSBPL1A ^@ http://purl.uniprot.org/uniprot/U3FP94 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9483:FOXI1 ^@ http://purl.uniprot.org/uniprot/A0A8I3X8U8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:PRICKLE2 ^@ http://purl.uniprot.org/uniprot/U3EPY0 ^@ Similarity ^@ Belongs to the prickle / espinas / testin family. http://togogenome.org/gene/9483:FAM149A ^@ http://purl.uniprot.org/uniprot/U3BSE2 ^@ Similarity ^@ Belongs to the FAM149 family. http://togogenome.org/gene/9483:DYNC1I1 ^@ http://purl.uniprot.org/uniprot/F6S1D1|||http://purl.uniprot.org/uniprot/F6SCA4|||http://purl.uniprot.org/uniprot/U3CMA6|||http://purl.uniprot.org/uniprot/U3D6B8 ^@ Similarity ^@ Belongs to the dynein intermediate chain family. http://togogenome.org/gene/9483:MECOM ^@ http://purl.uniprot.org/uniprot/F6SYP4|||http://purl.uniprot.org/uniprot/U3DP30 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:LOC100404555 ^@ http://purl.uniprot.org/uniprot/F7ID46 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:RPS3A ^@ http://purl.uniprot.org/uniprot/F7FTX6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS1 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.|||Cytoplasm|||May play a role during erythropoiesis through regulation of transcription factor DDIT3.|||Nucleus|||nucleolus http://togogenome.org/gene/9483:TEFM ^@ http://purl.uniprot.org/uniprot/F7IE95 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TEFM family.|||Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery.|||mitochondrion nucleoid http://togogenome.org/gene/9483:TET2 ^@ http://purl.uniprot.org/uniprot/F7B2Z8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TET family.|||Binds 1 Fe(2+) ion per subunit.|||Chromosome|||Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.|||The zinc ions have a structural role. http://togogenome.org/gene/9483:PHTF1 ^@ http://purl.uniprot.org/uniprot/U3FJ49 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:B2M ^@ http://purl.uniprot.org/uniprot/P63061|||http://purl.uniprot.org/uniprot/U3FI69 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta-2-microglobulin family.|||Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).|||Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.|||Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules (By similarity).|||Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules.|||Secreted http://togogenome.org/gene/9483:LOC100386021 ^@ http://purl.uniprot.org/uniprot/F7HAW4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9483:PDXP ^@ http://purl.uniprot.org/uniprot/U3E5L2 ^@ Cofactor|||Similarity ^@ Belongs to the HAD-like hydrolase superfamily.|||Divalent metal ions. Mg(2+) is the most effective. http://togogenome.org/gene/9483:LAMTOR2 ^@ http://purl.uniprot.org/uniprot/F7IBS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GAMAD family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/9483:OR10S1 ^@ http://purl.uniprot.org/uniprot/F7IT56 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:REN ^@ http://purl.uniprot.org/uniprot/Q9TSZ1 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A1 family.|||Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing.|||Interacts with ATP6AP2.|||Membrane|||Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.|||Secreted http://togogenome.org/gene/9483:RABGGTA ^@ http://purl.uniprot.org/uniprot/F7FA20 ^@ Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family.|||Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.|||Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. http://togogenome.org/gene/9483:KIFC1 ^@ http://purl.uniprot.org/uniprot/F7IR24 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9483:FAM13B ^@ http://purl.uniprot.org/uniprot/F6XUV0 ^@ Similarity ^@ Belongs to the FAM13 family. http://togogenome.org/gene/9483:SCG2 ^@ http://purl.uniprot.org/uniprot/U3FS88 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chromogranin/secretogranin protein family.|||Interacts with Secretogranin III/SCG3.|||Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules.|||Secreted http://togogenome.org/gene/9483:ORAI3 ^@ http://purl.uniprot.org/uniprot/F7I315 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Orai family.|||Membrane http://togogenome.org/gene/9483:CNGA4 ^@ http://purl.uniprot.org/uniprot/F7I9D4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:CCT7 ^@ http://purl.uniprot.org/uniprot/F6TEX0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm|||Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.|||Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. http://togogenome.org/gene/9483:B3GALNT2 ^@ http://purl.uniprot.org/uniprot/U3D6G8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:CHST3 ^@ http://purl.uniprot.org/uniprot/F6UUA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/9483:UROC1 ^@ http://purl.uniprot.org/uniprot/F6S143 ^@ Similarity ^@ Belongs to the urocanase family. http://togogenome.org/gene/9483:RRS1 ^@ http://purl.uniprot.org/uniprot/U3FNM9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRS1 family.|||Involved in ribosomal large subunit assembly.|||Nucleus http://togogenome.org/gene/9483:OPN3 ^@ http://purl.uniprot.org/uniprot/F7IH55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9483:OTULIN ^@ http://purl.uniprot.org/uniprot/A0A8J8Y147|||http://purl.uniprot.org/uniprot/U3AV46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C65 family. Otulin subfamily.|||Cytoplasm http://togogenome.org/gene/9483:SENP8 ^@ http://purl.uniprot.org/uniprot/F6WYT0 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/9483:MYADML2 ^@ http://purl.uniprot.org/uniprot/A0A2R8MAB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAL family.|||Membrane http://togogenome.org/gene/9483:LOC100408457 ^@ http://purl.uniprot.org/uniprot/A8CYI3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9483:LOC100389983 ^@ http://purl.uniprot.org/uniprot/F7INI1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9483:FOXN2 ^@ http://purl.uniprot.org/uniprot/U3EET7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:MYF6 ^@ http://purl.uniprot.org/uniprot/A0A8I3X9W2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:TLCD5 ^@ http://purl.uniprot.org/uniprot/F7IGM9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:MON2 ^@ http://purl.uniprot.org/uniprot/U3DXG9 ^@ Similarity ^@ Belongs to the MON2 family. http://togogenome.org/gene/9483:ETV6 ^@ http://purl.uniprot.org/uniprot/U3FNJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9483:DIPK2B ^@ http://purl.uniprot.org/uniprot/F7ISG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Secreted http://togogenome.org/gene/9483:NME4 ^@ http://purl.uniprot.org/uniprot/F6S5S0 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9483:ADAM17 ^@ http://purl.uniprot.org/uniprot/U3CYN9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:HOXB1 ^@ http://purl.uniprot.org/uniprot/F6X2V1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Labial subfamily.|||Nucleus http://togogenome.org/gene/9483:EIF4E ^@ http://purl.uniprot.org/uniprot/U3BQJ7 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/9483:NMI ^@ http://purl.uniprot.org/uniprot/F7HL49|||http://purl.uniprot.org/uniprot/U3BI76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NMI family.|||Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/9483:SLC30A5 ^@ http://purl.uniprot.org/uniprot/U3EDJ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Functions as a zinc transporter.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9483:MRPS24 ^@ http://purl.uniprot.org/uniprot/U3CV92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS3 family.|||Mitochondrion http://togogenome.org/gene/9483:GREM2 ^@ http://purl.uniprot.org/uniprot/F7IL92 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9483:APMAP ^@ http://purl.uniprot.org/uniprot/F6S5S8 ^@ Similarity ^@ Belongs to the strictosidine synthase family. http://togogenome.org/gene/9483:GABARAPL2 ^@ http://purl.uniprot.org/uniprot/F7HV98 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9483:FAM98C ^@ http://purl.uniprot.org/uniprot/F6YIR8 ^@ Similarity ^@ Belongs to the FAM98 family. http://togogenome.org/gene/9483:CDA ^@ http://purl.uniprot.org/uniprot/A0A2R8MEI9 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/9483:PCSK2 ^@ http://purl.uniprot.org/uniprot/U3CJ12|||http://purl.uniprot.org/uniprot/U3FAE0 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9483:LOC108589366 ^@ http://purl.uniprot.org/uniprot/A0A8I3X6J8 ^@ Function|||Subunit ^@ In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9483:TIMM9 ^@ http://purl.uniprot.org/uniprot/F7F0A5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9483:CITED1 ^@ http://purl.uniprot.org/uniprot/A0A8I3WMD9|||http://purl.uniprot.org/uniprot/F7CIL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CITED family.|||Nucleus http://togogenome.org/gene/9483:ENTPD7 ^@ http://purl.uniprot.org/uniprot/F7IHC4 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9483:LOXL1 ^@ http://purl.uniprot.org/uniprot/F6S0D4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/9483:PDZK1IP1 ^@ http://purl.uniprot.org/uniprot/F7DUI4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:GALNT1 ^@ http://purl.uniprot.org/uniprot/U3BYF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:SLC25A45 ^@ http://purl.uniprot.org/uniprot/A0A5F4VVU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9483:GRIA4 ^@ http://purl.uniprot.org/uniprot/A0A2R8P4U6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9483:TTI2 ^@ http://purl.uniprot.org/uniprot/F7HQT3 ^@ Similarity ^@ Belongs to the TTI2 family. http://togogenome.org/gene/9483:NEXMIF ^@ http://purl.uniprot.org/uniprot/F7H8J4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:HEATR1 ^@ http://purl.uniprot.org/uniprot/U3CG93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HEATR1/UTP10 family.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/9483:CREM ^@ http://purl.uniprot.org/uniprot/U3DB32 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:GNMT ^@ http://purl.uniprot.org/uniprot/F7I607 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family. http://togogenome.org/gene/9483:POGLUT3 ^@ http://purl.uniprot.org/uniprot/F7H5J1 ^@ Similarity ^@ Belongs to the KDELC family. http://togogenome.org/gene/9483:NME2 ^@ http://purl.uniprot.org/uniprot/F6YGJ2 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9483:FLCN ^@ http://purl.uniprot.org/uniprot/U3DLI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the folliculin family.|||Lysosome membrane|||Membrane|||Nucleus|||centrosome|||cilium|||cytosol|||spindle http://togogenome.org/gene/9483:GPR4 ^@ http://purl.uniprot.org/uniprot/A0A2R8NAC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:LEF1 ^@ http://purl.uniprot.org/uniprot/F7G9Z6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCF/LEF family.|||Nucleus http://togogenome.org/gene/9483:PRTFDC1 ^@ http://purl.uniprot.org/uniprot/U3EZ09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/9483:SGK1 ^@ http://purl.uniprot.org/uniprot/F7I0Y6|||http://purl.uniprot.org/uniprot/U3DA47 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:ARPC2 ^@ http://purl.uniprot.org/uniprot/U3CJ54 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC2 family.|||Cell projection|||Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton|||synaptosome http://togogenome.org/gene/9483:ITGA6 ^@ http://purl.uniprot.org/uniprot/U3FDN1|||http://purl.uniprot.org/uniprot/U3FHX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9483:MAS1 ^@ http://purl.uniprot.org/uniprot/U3CF76 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9483:MTNR1A ^@ http://purl.uniprot.org/uniprot/F6VX53 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.|||Membrane http://togogenome.org/gene/9483:CCL24 ^@ http://purl.uniprot.org/uniprot/A0A8I3WWJ4 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9483:FMC1 ^@ http://purl.uniprot.org/uniprot/U3FMF8 ^@ Similarity ^@ Belongs to the FMC1 family. http://togogenome.org/gene/9483:ELOVL1 ^@ http://purl.uniprot.org/uniprot/U3D550 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ELO family. ELOVL1 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.|||Endoplasmic reticulum membrane|||Interacts with LASS2, TECR and HSD17B12.|||Membrane|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9483:GLUD1 ^@ http://purl.uniprot.org/uniprot/U3C0I9 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/9483:HSD17B1 ^@ http://purl.uniprot.org/uniprot/Q9GME2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm|||Favors the reduction of estrogens and androgens. Uses preferentially NADH. http://togogenome.org/gene/9483:CUTC ^@ http://purl.uniprot.org/uniprot/U3EID7 ^@ Similarity ^@ Belongs to the CutC family. http://togogenome.org/gene/9483:CDCA5 ^@ http://purl.uniprot.org/uniprot/F7BP81 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus http://togogenome.org/gene/9483:ANAPC13 ^@ http://purl.uniprot.org/uniprot/F7I106 ^@ Function|||Similarity ^@ Belongs to the APC13 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. http://togogenome.org/gene/9483:FEZ1 ^@ http://purl.uniprot.org/uniprot/A0A2R8M9E2 ^@ Similarity ^@ Belongs to the zygin family. http://togogenome.org/gene/9483:TFB2M ^@ http://purl.uniprot.org/uniprot/A0A8I4A234 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:CLTC ^@ http://purl.uniprot.org/uniprot/U3D6K0|||http://purl.uniprot.org/uniprot/U3F8X4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin heavy chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||Membrane|||coated pit http://togogenome.org/gene/9483:NDUFB4 ^@ http://purl.uniprot.org/uniprot/F7HJN2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB4 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:SENP1 ^@ http://purl.uniprot.org/uniprot/U3FPX9 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/9483:ASB8 ^@ http://purl.uniprot.org/uniprot/A0A2R8MBP3 ^@ Function|||Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family.|||May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/9483:MND1 ^@ http://purl.uniprot.org/uniprot/F7HA07 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MND1 family.|||Nucleus|||Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. http://togogenome.org/gene/9483:TMEM167B ^@ http://purl.uniprot.org/uniprot/F6UZC6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KISH family.|||Golgi apparatus membrane|||Involved in the early part of the secretory pathway.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:PTPN18 ^@ http://purl.uniprot.org/uniprot/U3BL66 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. http://togogenome.org/gene/9483:RBM8A ^@ http://purl.uniprot.org/uniprot/F7DRZ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RBM8A family.|||Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.|||Cytoplasm|||Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.|||Nucleus|||Nucleus speckle http://togogenome.org/gene/9483:CAVIN2 ^@ http://purl.uniprot.org/uniprot/F7F4U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/9483:GLMP ^@ http://purl.uniprot.org/uniprot/A0A8I3XF97 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GLMP family.|||Interacts (via lumenal domain) with lysosomal protein MFSD1; the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stability and lysosomal localization of MFSD1.|||Lysosome membrane|||Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization. http://togogenome.org/gene/9483:ATOSB ^@ http://purl.uniprot.org/uniprot/F6UDZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATOS family.|||Nucleus http://togogenome.org/gene/9483:FBXO48 ^@ http://purl.uniprot.org/uniprot/F7GBR8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2.|||Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1. Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway. Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation. http://togogenome.org/gene/9483:VAMP2 ^@ http://purl.uniprot.org/uniprot/A0A2R8P2U1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9483:MGAT2 ^@ http://purl.uniprot.org/uniprot/U3DIB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 16 (GT16) protein family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:TGFBR1 ^@ http://purl.uniprot.org/uniprot/F7H653 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9483:LOC100408493 ^@ http://purl.uniprot.org/uniprot/F6WV13 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9483:PARL ^@ http://purl.uniprot.org/uniprot/U3BKB5|||http://purl.uniprot.org/uniprot/U3C4X5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:LOC100406761 ^@ http://purl.uniprot.org/uniprot/A0A8I4A2X5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space|||Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. http://togogenome.org/gene/9483:NCBP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8MCM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NCBP1 family.|||Nucleus http://togogenome.org/gene/9483:COQ6 ^@ http://purl.uniprot.org/uniprot/U3BRU6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UbiH/COQ6 family.|||Cell projection|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ7.|||FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.|||Golgi apparatus|||Mitochondrion inner membrane http://togogenome.org/gene/9483:PSMB7 ^@ http://purl.uniprot.org/uniprot/F7DRQ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:LPXN ^@ http://purl.uniprot.org/uniprot/A0A2R8MHV6|||http://purl.uniprot.org/uniprot/U3FPD0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the paxillin family.|||Cell membrane|||Cytoplasm|||Nucleus|||The LIM domain 3 is critical for focal adhesion targeting and the suppression of paxillin (PXN) tyrosine phosphorylation. The LIM domain 3 alone or both LIM domains 3 and 4 can mediate interaction with AR.|||Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN).|||focal adhesion|||perinuclear region|||podosome http://togogenome.org/gene/9483:NME7 ^@ http://purl.uniprot.org/uniprot/U3E823 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||cilium axoneme http://togogenome.org/gene/9483:SLC24A2 ^@ http://purl.uniprot.org/uniprot/U3DDA8|||http://purl.uniprot.org/uniprot/U3E340 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/9483:SRP68 ^@ http://purl.uniprot.org/uniprot/U3D7E0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP68 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.|||Cytoplasm|||nucleolus http://togogenome.org/gene/9483:HMGN5 ^@ http://purl.uniprot.org/uniprot/A0A5F4WAP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/9483:HMGN1 ^@ http://purl.uniprot.org/uniprot/F7II06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/9483:MRPL14 ^@ http://purl.uniprot.org/uniprot/U3ECB1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL14 family. http://togogenome.org/gene/9483:SNX13 ^@ http://purl.uniprot.org/uniprot/F6Z6T9|||http://purl.uniprot.org/uniprot/U3FK03 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9483:HLF ^@ http://purl.uniprot.org/uniprot/A0A8I3WL88|||http://purl.uniprot.org/uniprot/F7FH72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/9483:YPEL4 ^@ http://purl.uniprot.org/uniprot/F7CLM8 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9483:LOC100894898 ^@ http://purl.uniprot.org/uniprot/A0A2R8MPE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ATPase subunit F6 family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.|||Mitochondrion|||Mitochondrion inner membrane http://togogenome.org/gene/9483:SPTBN2 ^@ http://purl.uniprot.org/uniprot/U3DCT7 ^@ Similarity ^@ Belongs to the spectrin family. http://togogenome.org/gene/9483:GSX2 ^@ http://purl.uniprot.org/uniprot/F6UMR1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:APOM ^@ http://purl.uniprot.org/uniprot/A0A5F4W6R8|||http://purl.uniprot.org/uniprot/F7HY96 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family. Highly divergent.|||Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.|||Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.|||Secreted http://togogenome.org/gene/9483:NADSYN1 ^@ http://purl.uniprot.org/uniprot/U3D6C7 ^@ Similarity|||Subunit ^@ Homohexamer.|||In the C-terminal section; belongs to the NAD synthetase family. http://togogenome.org/gene/9483:MITF ^@ http://purl.uniprot.org/uniprot/A0A5K1UW48|||http://purl.uniprot.org/uniprot/F6S413|||http://purl.uniprot.org/uniprot/F7FA74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/9483:FUT1 ^@ http://purl.uniprot.org/uniprot/U3E6W4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 11 family.|||Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose residue of glycoconjugates through an alpha(1,2) linkage leading to H antigen synthesis that is an intermediate substrate in the synthesis of ABO blood group antigens. H antigen is essential for maturation of the glomerular layer of the main olfactory bulb, in cell migration and early cell-cell contacts during tumor associated angiogenesis (By similarity). Preferentially fucosylates soluble lactose and to a lesser extent fucosylates glycolipids gangliosides GA1 and GM1a.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9483:MIXL1 ^@ http://purl.uniprot.org/uniprot/F7I8Q6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:LOC100410615 ^@ http://purl.uniprot.org/uniprot/F7H5T1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:PCYT1A ^@ http://purl.uniprot.org/uniprot/U3DKF2 ^@ Function|||Similarity ^@ Belongs to the cytidylyltransferase family.|||Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. http://togogenome.org/gene/9483:SOSTDC1 ^@ http://purl.uniprot.org/uniprot/F6USQ7 ^@ Caution|||Similarity ^@ Belongs to the sclerostin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:DDIT4L ^@ http://purl.uniprot.org/uniprot/F6UJJ8 ^@ Similarity ^@ Belongs to the DDIT4 family. http://togogenome.org/gene/9483:NXPH3 ^@ http://purl.uniprot.org/uniprot/F7CES0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/9483:FOXS1 ^@ http://purl.uniprot.org/uniprot/F7ELQ3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:UCHL1 ^@ http://purl.uniprot.org/uniprot/U3FKC1 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/9483:OSBPL6 ^@ http://purl.uniprot.org/uniprot/F7IH05 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9483:GSKIP ^@ http://purl.uniprot.org/uniprot/U3CU76 ^@ Similarity ^@ Belongs to the GSKIP family. http://togogenome.org/gene/9483:FAM8A1 ^@ http://purl.uniprot.org/uniprot/U3BGC6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:ERBB2 ^@ http://purl.uniprot.org/uniprot/F7CBG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/9483:MAP3K14 ^@ http://purl.uniprot.org/uniprot/A0A8I4A3R3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Cytoplasm|||Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. http://togogenome.org/gene/9483:CXCR4 ^@ http://purl.uniprot.org/uniprot/Q8HZU1|||http://purl.uniprot.org/uniprot/U3FG72 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell junction|||Cell membrane|||Early endosome|||Endosome|||Late endosome|||Lysosome|||Membrane|||Monomer. Can form homodimers. Interacts with CD164. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARR3; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts with RNF113A; the interaction, enhanced by CXCL12, promotes CXCR4 ubiquitination and subsequent degradation. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, promotes CXCR4 ubiquitination and leads to its degradation. Interacts with extracellular ubiquitin. Interacts with DBN1; this interaction is enhanced by antigenic stimulation. Following LPS binding, may form a complex with GDF5, HSP90AA1 and HSPA8.|||O- and N-glycosylated. N-glycosylation can mask coreceptor function. The O-glycosylation chondroitin sulfate attachment does not affect interaction with CXCL12/SDF-1alpha nor its coreceptor activity.|||Phosphorylated on agonist stimulation. Rapidly phosphorylated on serine and threonine residues in the C-terminal. Phosphorylation at Ser-324 and Ser-325 leads to recruitment of ITCH, ubiquitination and protein degradation.|||Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity).|||Sulfation is required for efficient binding of CXCL12/SDF-1alpha and promotes its dimerization.|||Ubiquitinated after ligand binding, leading to its degradation. Ubiquitinated by ITCH at the cell membrane on agonist stimulation. The ubiquitin-dependent mechanism, endosomal sorting complex required for transport (ESCRT), then targets CXCR4 for lysosomal degradation. This process is dependent also on prior Ser-/Thr-phosphorylation in the C-terminal of CXCR4. Also binding of ARRB1 to STAM negatively regulates CXCR4 sorting to lysosomes though modulating ubiquitination of SFR5S. http://togogenome.org/gene/9483:ADTRP ^@ http://purl.uniprot.org/uniprot/F7DN37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIG1 family.|||Membrane http://togogenome.org/gene/9483:FEN1 ^@ http://purl.uniprot.org/uniprot/F7GXF8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Mitochondrion|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9483:ASXL1 ^@ http://purl.uniprot.org/uniprot/U3CD57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Asx family.|||Nucleus http://togogenome.org/gene/9483:FMO2 ^@ http://purl.uniprot.org/uniprot/A0A221I0G7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9483:IL33 ^@ http://purl.uniprot.org/uniprot/A0A2R8PF76|||http://purl.uniprot.org/uniprot/F6PUA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family. Highly divergent.|||Chromosome|||Nucleus|||Secreted|||Vesicle|||secretory vesicle http://togogenome.org/gene/9483:RGS3 ^@ http://purl.uniprot.org/uniprot/F6RBS6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:DTX3L ^@ http://purl.uniprot.org/uniprot/U3CUK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Deltex family.|||Cytoplasm http://togogenome.org/gene/9483:BDH1 ^@ http://purl.uniprot.org/uniprot/U3C2M8 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9483:CASTOR1 ^@ http://purl.uniprot.org/uniprot/F6TTG3|||http://purl.uniprot.org/uniprot/U3E167 ^@ Similarity ^@ Belongs to the GATS family. http://togogenome.org/gene/9483:KCNK2 ^@ http://purl.uniprot.org/uniprot/A0A8I3WU10|||http://purl.uniprot.org/uniprot/F6UI26|||http://purl.uniprot.org/uniprot/U3EGJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9483:DARS2 ^@ http://purl.uniprot.org/uniprot/F7HYM1 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. http://togogenome.org/gene/9483:ADRA1D ^@ http://purl.uniprot.org/uniprot/F7CTX8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.|||Membrane|||This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. http://togogenome.org/gene/9483:TSPO2 ^@ http://purl.uniprot.org/uniprot/F6R8U7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TspO/BZRP family.|||Membrane http://togogenome.org/gene/9483:SLC35A2 ^@ http://purl.uniprot.org/uniprot/A0A8I3X9V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:ENTPD8 ^@ http://purl.uniprot.org/uniprot/A0A2R8PDR7 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9483:CAJA-DRA ^@ http://purl.uniprot.org/uniprot/U3E867 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/9483:GNAQ ^@ http://purl.uniprot.org/uniprot/F7IC22 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/9483:HOXB7 ^@ http://purl.uniprot.org/uniprot/F7AVK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9483:LRP6 ^@ http://purl.uniprot.org/uniprot/A0A8I4A282|||http://purl.uniprot.org/uniprot/U3DLY0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LDLR family.|||Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes.|||Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:POLR3G ^@ http://purl.uniprot.org/uniprot/F6YUR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC7 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/9483:FAM174C ^@ http://purl.uniprot.org/uniprot/U3FFU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM174 family.|||Membrane http://togogenome.org/gene/9483:AQP4 ^@ http://purl.uniprot.org/uniprot/F7I6W3|||http://purl.uniprot.org/uniprot/U3E3H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9483:SMU1 ^@ http://purl.uniprot.org/uniprot/F7HXH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SMU1 family.|||Nucleus speckle http://togogenome.org/gene/9483:LOC100410631 ^@ http://purl.uniprot.org/uniprot/F7I360 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS12 family. http://togogenome.org/gene/9483:SLC4A8 ^@ http://purl.uniprot.org/uniprot/F7EQN7 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9483:TATDN3 ^@ http://purl.uniprot.org/uniprot/F7IRW0 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. http://togogenome.org/gene/9483:TUSC3 ^@ http://purl.uniprot.org/uniprot/F6T1G7|||http://purl.uniprot.org/uniprot/F7C9S5|||http://purl.uniprot.org/uniprot/U3BNG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:FGD2 ^@ http://purl.uniprot.org/uniprot/F7HHG0|||http://purl.uniprot.org/uniprot/F7HHJ2 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9483:GTF3C5 ^@ http://purl.uniprot.org/uniprot/U3ESU6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:WARS1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YCI7 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9483:RUNX1 ^@ http://purl.uniprot.org/uniprot/U3FHT7 ^@ Function|||Subcellular Location Annotation ^@ Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.|||Nucleus http://togogenome.org/gene/9483:ACTC1 ^@ http://purl.uniprot.org/uniprot/A0A8I4A3C0 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9483:LOC103788988 ^@ http://purl.uniprot.org/uniprot/A0A8I3VYN9 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9483:PELI1 ^@ http://purl.uniprot.org/uniprot/U3F2B6 ^@ Function|||Similarity ^@ Belongs to the pellino family.|||E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. http://togogenome.org/gene/9483:MTERF3 ^@ http://purl.uniprot.org/uniprot/U3EUI8 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/9483:SLC37A4 ^@ http://purl.uniprot.org/uniprot/U3DRQ5|||http://purl.uniprot.org/uniprot/U3E234 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Membrane http://togogenome.org/gene/9483:DEFB124 ^@ http://purl.uniprot.org/uniprot/A0A5F4W2I1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9483:STX11 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y9W3 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9483:GABARAPL1 ^@ http://purl.uniprot.org/uniprot/F7HVH6 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9483:ARL3 ^@ http://purl.uniprot.org/uniprot/F6SUZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||centrosome http://togogenome.org/gene/9483:BOK ^@ http://purl.uniprot.org/uniprot/U3CXP7 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9483:C1S ^@ http://purl.uniprot.org/uniprot/U3BUP2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:LOC108587672 ^@ http://purl.uniprot.org/uniprot/F7I0E1 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/9483:LOC103788005 ^@ http://purl.uniprot.org/uniprot/A0A8I3WH84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom22 family.|||Mitochondrion outer membrane http://togogenome.org/gene/9483:HFE ^@ http://purl.uniprot.org/uniprot/F7GRH8 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9483:BTC ^@ http://purl.uniprot.org/uniprot/A0A5F4VVZ7|||http://purl.uniprot.org/uniprot/A0A8I3WV70 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:PWP2 ^@ http://purl.uniprot.org/uniprot/A0A5F4W2D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat PWP2 family.|||nucleolus http://togogenome.org/gene/9483:NT5E ^@ http://purl.uniprot.org/uniprot/U3CHA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 5'-nucleotidase family.|||Membrane http://togogenome.org/gene/9483:COG8 ^@ http://purl.uniprot.org/uniprot/U3DHB4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COG8 family.|||Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:ABI3 ^@ http://purl.uniprot.org/uniprot/F6VGL5 ^@ Similarity ^@ Belongs to the ABI family. http://togogenome.org/gene/9483:MED11 ^@ http://purl.uniprot.org/uniprot/F6UN01 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 11 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9483:NUP85 ^@ http://purl.uniprot.org/uniprot/F7IG61 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nucleoporin Nup85 family.|||Component of the nuclear pore complex (NPC).|||Functions as a component of the nuclear pore complex (NPC).|||Nucleus membrane|||nuclear pore complex http://togogenome.org/gene/9483:GINS3 ^@ http://purl.uniprot.org/uniprot/F6T6J0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS3/PSF3 family.|||Chromosome|||Component of the GINS complex.|||Nucleus|||The GINS complex plays an essential role in the initiation of DNA replication. http://togogenome.org/gene/9483:SCD5 ^@ http://purl.uniprot.org/uniprot/F7HMC4 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Membrane|||The histidine box domains are involved in binding the catalytic metal ions. http://togogenome.org/gene/9483:PPP6C ^@ http://purl.uniprot.org/uniprot/U3EMC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/9483:TAF2 ^@ http://purl.uniprot.org/uniprot/A0A8I3WW93|||http://purl.uniprot.org/uniprot/U3F1J8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF2 family.|||Nucleus http://togogenome.org/gene/9483:FOXA1 ^@ http://purl.uniprot.org/uniprot/U3BW21 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:ACSL1 ^@ http://purl.uniprot.org/uniprot/F7C1E6|||http://purl.uniprot.org/uniprot/Q9GLP3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.|||Endoplasmic reticulum membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9483:MED28 ^@ http://purl.uniprot.org/uniprot/U3DSH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 28 family.|||Nucleus http://togogenome.org/gene/9483:ELAC1 ^@ http://purl.uniprot.org/uniprot/U3DIH8 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/9483:RAX ^@ http://purl.uniprot.org/uniprot/F7DZ10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9483:CHST6 ^@ http://purl.uniprot.org/uniprot/F7ITB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/9483:LOC108592192 ^@ http://purl.uniprot.org/uniprot/F7H244 ^@ Similarity ^@ Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family. http://togogenome.org/gene/9483:ACTR2 ^@ http://purl.uniprot.org/uniprot/F7EI23|||http://purl.uniprot.org/uniprot/U3EIC6 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9483:GJB2 ^@ http://purl.uniprot.org/uniprot/F7HZW5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Beta-type (group I) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9483:KHDC3L ^@ http://purl.uniprot.org/uniprot/U3DJS3 ^@ Similarity ^@ Belongs to the KHDC1 family. http://togogenome.org/gene/9483:LOC100390575 ^@ http://purl.uniprot.org/uniprot/A0A2R8MCW0 ^@ Similarity ^@ Belongs to the PRR23 family. http://togogenome.org/gene/9483:KCTD20 ^@ http://purl.uniprot.org/uniprot/F7IJE3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:CDK10 ^@ http://purl.uniprot.org/uniprot/F7C8F5|||http://purl.uniprot.org/uniprot/U3CHA2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:LOC100406834 ^@ http://purl.uniprot.org/uniprot/H9KXU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:SLC25A23 ^@ http://purl.uniprot.org/uniprot/U3DCE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9483:MOGAT1 ^@ http://purl.uniprot.org/uniprot/F7ID79 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:TMA16 ^@ http://purl.uniprot.org/uniprot/U3CI81 ^@ Function|||Similarity|||Subunit ^@ Associates with pre-60S ribosomal particles.|||Belongs to the TMA16 family.|||Involved in the biogenesis of the 60S ribosomal subunit in the nucleus. http://togogenome.org/gene/9483:ANXA3 ^@ http://purl.uniprot.org/uniprot/F7H4N2 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9483:C4H6orf58 ^@ http://purl.uniprot.org/uniprot/A0A8I3W6B0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LEG1 family.|||Secreted http://togogenome.org/gene/9483:LSM3 ^@ http://purl.uniprot.org/uniprot/F7ICR4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/9483:HSD17B7 ^@ http://purl.uniprot.org/uniprot/U3EMT5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily. http://togogenome.org/gene/9483:GOLT1A ^@ http://purl.uniprot.org/uniprot/F7IRX2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||May be involved in fusion of ER-derived transport vesicles with the Golgi complex.|||Membrane http://togogenome.org/gene/9483:LOC100411198 ^@ http://purl.uniprot.org/uniprot/Q9N2D2 ^@ Activity Regulation|||Developmental Stage|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase A1 family.|||Expressed in adult, not neonate-specific as in other organisms.|||Hydrolyzes a variety of proteins.|||Inhibited by pepstatin.|||Monomer. http://togogenome.org/gene/9483:PIK3R2 ^@ http://purl.uniprot.org/uniprot/F6ZCI2 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/9483:ARF5 ^@ http://purl.uniprot.org/uniprot/F7HBX3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/9483:CEPT1 ^@ http://purl.uniprot.org/uniprot/F7G2A6 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/9483:LOC100389231 ^@ http://purl.uniprot.org/uniprot/A0A8I3WIG8|||http://purl.uniprot.org/uniprot/F7IA32 ^@ Similarity ^@ Belongs to the MIF family. http://togogenome.org/gene/9483:LOC100387786 ^@ http://purl.uniprot.org/uniprot/F7FTC2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.|||Endoplasmic reticulum membrane|||Required for N-linked oligosaccharide assembly. http://togogenome.org/gene/9483:ABCF3 ^@ http://purl.uniprot.org/uniprot/F7D4K0 ^@ Subunit ^@ Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and NHERF1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through NHERF1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation. http://togogenome.org/gene/9483:FAIM2 ^@ http://purl.uniprot.org/uniprot/F7GY56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9483:EPS8 ^@ http://purl.uniprot.org/uniprot/U3CNU6 ^@ Similarity ^@ Belongs to the EPS8 family. http://togogenome.org/gene/9483:ACSL6 ^@ http://purl.uniprot.org/uniprot/U3D011|||http://purl.uniprot.org/uniprot/U3DNT5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion outer membrane http://togogenome.org/gene/9483:PSMD13 ^@ http://purl.uniprot.org/uniprot/U3C564 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S11 family.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. http://togogenome.org/gene/9483:PNP ^@ http://purl.uniprot.org/uniprot/F7IC61 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family.|||Homotrimer.|||The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. http://togogenome.org/gene/9483:SRF ^@ http://purl.uniprot.org/uniprot/F7HCP4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:NUDT5 ^@ http://purl.uniprot.org/uniprot/U3DDE9 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/9483:RAB4A ^@ http://purl.uniprot.org/uniprot/A0A5F4VSH5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. http://togogenome.org/gene/9483:LOC100390461 ^@ http://purl.uniprot.org/uniprot/F6X0G4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9483:LOC100410089 ^@ http://purl.uniprot.org/uniprot/A0A2R8M6K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:CHCHD4 ^@ http://purl.uniprot.org/uniprot/U3EA41 ^@ Subcellular Location Annotation ^@ Mitochondrion intermembrane space http://togogenome.org/gene/9483:ACHE ^@ http://purl.uniprot.org/uniprot/U3EB48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Secreted http://togogenome.org/gene/9483:TXNL4A ^@ http://purl.uniprot.org/uniprot/A0A8I4A2K8|||http://purl.uniprot.org/uniprot/U3CQA8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/9483:RBM46 ^@ http://purl.uniprot.org/uniprot/F7CWB1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:GCNT3 ^@ http://purl.uniprot.org/uniprot/F7FUY3 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:APPL1 ^@ http://purl.uniprot.org/uniprot/F7FXM1 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Endosome membrane|||Membrane|||Nucleus|||phagosome|||ruffle http://togogenome.org/gene/9483:RPS28 ^@ http://purl.uniprot.org/uniprot/F6WXM1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/9483:CCL7 ^@ http://purl.uniprot.org/uniprot/A0A5F4WJQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9483:CCNG2 ^@ http://purl.uniprot.org/uniprot/F6VUX7 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9483:NFRKB ^@ http://purl.uniprot.org/uniprot/A0A8I3W1H0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:SEC24D ^@ http://purl.uniprot.org/uniprot/U3CPH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9483:EEF2 ^@ http://purl.uniprot.org/uniprot/A0SXL6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Binds to 80S ribosomes. Actively translating ribosomes show mutually exclusive binding of eIF5a (EIF5A or EIF5A2) and EEF2/eEF2. Interacts with SERBP1; interaction sequesters EEF2/eEF2 at the A-site of the ribosome, thereby blocking the interaction sites of the mRNA-tRNA complex, promoting ribosome stabilization and hibernation (By similarity). Interacts with HABP4; interaction takes place at the A-site of hibernating ribosomes and promotes ribosome stabilization (By similarity). Component of the mRNA surveillance SURF complex, at least composed of ERF1, ERF3 (ERF3A or ERF3B), EEF2, UPF1/RENT1, SMG1, SMG8 and SMG9. Interacts with RBPMS2 (By similarity).|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm|||Diphthamide is 2-[3-carboxyamido-3-(trimethyl-ammonio)propyl]histidine (By similarity).|||ISGylated.|||Nucleus|||Phosphorylation by EF-2 kinase completely inactivates EF-2; it requires prior phosphorylation by CDK2 at Ser-595 during mitotic prometaphase. Phosphorylation by CSK promotes SUMOylation, proteolytic cleavage, and nuclear translocation if the C-terminal fragment.|||Proteolytically processed at two sites following phosphorylation by CSK.|||SUMOylated following phosphorylation by CSK, promotes proteolytic cleavage. http://togogenome.org/gene/9483:RPL6 ^@ http://purl.uniprot.org/uniprot/A0A8I3WR85 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL6 family. http://togogenome.org/gene/9483:HCFC2 ^@ http://purl.uniprot.org/uniprot/F7HUQ6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:BAK1 ^@ http://purl.uniprot.org/uniprot/F7ICC2 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9483:PTGDR ^@ http://purl.uniprot.org/uniprot/A0A2R8NFM2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9483:MAPK6 ^@ http://purl.uniprot.org/uniprot/U3DTN7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9483:GREM1 ^@ http://purl.uniprot.org/uniprot/F6R9I8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Secreted http://togogenome.org/gene/9483:PLAC8L1 ^@ http://purl.uniprot.org/uniprot/F7DT58 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/9483:PLK2 ^@ http://purl.uniprot.org/uniprot/F7HJL7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. http://togogenome.org/gene/9483:GTF2H3 ^@ http://purl.uniprot.org/uniprot/U3CMZ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB4 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.|||Nucleus|||Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7. http://togogenome.org/gene/9483:SPRYD3 ^@ http://purl.uniprot.org/uniprot/U3CLM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Nucleus http://togogenome.org/gene/9483:LOC100399393 ^@ http://purl.uniprot.org/uniprot/F7IRG6 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/9483:ARL2BP ^@ http://purl.uniprot.org/uniprot/F7C9D0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARL2BP family.|||Cytoplasm|||Mitochondrion intermembrane space|||Nucleus|||Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.|||centrosome|||cilium basal body http://togogenome.org/gene/9483:LOC100404838 ^@ http://purl.uniprot.org/uniprot/A0A2R8PER2 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9483:PCBD2 ^@ http://purl.uniprot.org/uniprot/F7HYZ8 ^@ Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family. http://togogenome.org/gene/9483:TMEM161A ^@ http://purl.uniprot.org/uniprot/U3FUY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM161 family.|||Membrane http://togogenome.org/gene/9483:PTDSS2 ^@ http://purl.uniprot.org/uniprot/F7IDD1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphatidyl serine synthase family.|||Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:SQSTM1 ^@ http://purl.uniprot.org/uniprot/F7G7S9 ^@ Subcellular Location Annotation ^@ Lysosome|||autophagosome http://togogenome.org/gene/9483:SPTY2D1 ^@ http://purl.uniprot.org/uniprot/F6RDJ0 ^@ Similarity ^@ Belongs to the SPT2 family. http://togogenome.org/gene/9483:SH3BP5L ^@ http://purl.uniprot.org/uniprot/F7IK25 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SH3BP5 family.|||Cytoplasm|||Functions as guanine nucleotide exchange factor (GEF) for RAB11A.|||Interacts with GDP-bound and nucleotide-free forms of RAB11A.|||The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape. http://togogenome.org/gene/9483:KCNH3 ^@ http://purl.uniprot.org/uniprot/F7IQF7 ^@ Subcellular Location Annotation|||Subunit ^@ Membrane|||The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. http://togogenome.org/gene/9483:EPHA4 ^@ http://purl.uniprot.org/uniprot/U3EIW0 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome|||Membrane http://togogenome.org/gene/9483:SCAMP2 ^@ http://purl.uniprot.org/uniprot/F6UFC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/9483:PXMP4 ^@ http://purl.uniprot.org/uniprot/A0A8I3X939 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Interacts with PEX19.|||Peroxisome membrane http://togogenome.org/gene/9483:TNF ^@ http://purl.uniprot.org/uniprot/Q19LH4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Cell membrane|||Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity). Promotes osteoclastogenesis and therefore mediates bone resorption (By similarity).|||Homotrimer. Interacts with SPPL2B (By similarity).|||Membrane|||O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.|||Secreted|||The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.|||The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1 (By similarity).|||The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space (By similarity).|||The soluble form is demyristoylated by SIRT6, promoting its secretion. http://togogenome.org/gene/9483:SLC18B1 ^@ http://purl.uniprot.org/uniprot/A0A8I3W283 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:ANXA2 ^@ http://purl.uniprot.org/uniprot/A0A8I4A3A1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||Membrane|||basement membrane http://togogenome.org/gene/9483:RDH12 ^@ http://purl.uniprot.org/uniprot/U3DUP1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9483:NFE2L1 ^@ http://purl.uniprot.org/uniprot/U3FVE9 ^@ Similarity ^@ Belongs to the bZIP family. CNC subfamily. http://togogenome.org/gene/9483:CD40 ^@ http://purl.uniprot.org/uniprot/Q3LRP1|||http://purl.uniprot.org/uniprot/U3C9Y9 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer and homodimer. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts with TRAF6 and MAP3K8; the interaction is required for ERK activation (By similarity).|||Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). http://togogenome.org/gene/9483:PARP15 ^@ http://purl.uniprot.org/uniprot/F7IL00 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9483:CLIC1 ^@ http://purl.uniprot.org/uniprot/F7IM19 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cell membrane|||Cytoplasm|||Endoplasmic reticulum|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane|||Nucleus membrane http://togogenome.org/gene/9483:LIPG ^@ http://purl.uniprot.org/uniprot/F6V0B4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9483:JPT1 ^@ http://purl.uniprot.org/uniprot/U3B1Q3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:GABRA1 ^@ http://purl.uniprot.org/uniprot/F7GM19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9483:PDE4D ^@ http://purl.uniprot.org/uniprot/F6VBV7|||http://purl.uniprot.org/uniprot/F7AQU4|||http://purl.uniprot.org/uniprot/F7B975|||http://purl.uniprot.org/uniprot/U3BNV5 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9483:CDC20 ^@ http://purl.uniprot.org/uniprot/F7G9N7 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/9483:FBN1 ^@ http://purl.uniprot.org/uniprot/F7ALZ5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fibrillin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9483:NDFIP1 ^@ http://purl.uniprot.org/uniprot/U3FXR9 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Membrane http://togogenome.org/gene/9483:LOC100411007 ^@ http://purl.uniprot.org/uniprot/U3FPJ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||May be involved in vesicle transport between the ER and the Golgi complex.|||Membrane http://togogenome.org/gene/9483:MTM1 ^@ http://purl.uniprot.org/uniprot/U3BTU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/9483:GFUS ^@ http://purl.uniprot.org/uniprot/U3C1T5 ^@ Function|||Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.|||Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. http://togogenome.org/gene/9483:RPAP2 ^@ http://purl.uniprot.org/uniprot/A0A8I3W2L5|||http://purl.uniprot.org/uniprot/F7EDE7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD.|||Belongs to the RPAP2 family.|||Nucleus|||Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes. http://togogenome.org/gene/9483:AADACL3 ^@ http://purl.uniprot.org/uniprot/F6X991 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/9483:GATAD1 ^@ http://purl.uniprot.org/uniprot/F7AXR7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:GRB10 ^@ http://purl.uniprot.org/uniprot/A0A2R8N0W5|||http://purl.uniprot.org/uniprot/A0A5K1VG16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRB7/10/14 family.|||Cytoplasm http://togogenome.org/gene/9483:CORO1A ^@ http://purl.uniprot.org/uniprot/U3FGQ1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat coronin family.|||Binds actin.|||Membrane|||cell cortex|||cytoskeleton|||phagosome membrane http://togogenome.org/gene/9483:NR3C1 ^@ http://purl.uniprot.org/uniprot/A0A6D5HP83|||http://purl.uniprot.org/uniprot/Q6XLJ0|||http://purl.uniprot.org/uniprot/U3EM87 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Acetylation by CLOCK reduces its binding to glucocorticoid response elements and its transcriptional activity.|||Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. The ligand-binding domain is required for correct chromosome segregation during mitosis although ligand binding is not required.|||Cytoplasm|||Heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B, and FKBP5 or another immunophilin such as PPID, STIP1, or the immunophilin homolog PPP5C. Upon ligand binding FKBP5 dissociates from the complex and FKBP4 takes its place, thereby linking the complex to dynein and mediating transport to the nucleus, where the complex dissociates. Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones CDC37, PPP5C, TSC1 and client protein TSC2, CDK4, AKT, RAF1 and NR3C1; this complex does not contain co-chaperones STIP1/HOP and PTGES3/p23. Directly interacts with UNC45A. Binds to DNA as a homodimer, and as heterodimer with NR3C2 or the retinoid X receptor. Binds STAT5A and STAT5B homodimers and heterodimers. Interacts with NRIP1, POU2F1, POU2F2 and TRIM28. Interacts with several coactivator complexes, including the SMARCA4 complex, CREBBP/EP300, TADA2L (Ada complex) and p160 coactivators such as NCOA2 and NCOA6. Interaction with BAG1 inhibits transactivation. Interacts with HEXIM1 and TGFB1I1. Interacts with NCOA1. Interacts with NCOA3, SMARCA4, SMARCC1, SMARCD1, and SMARCE1. Interacts with CLOCK, CRY1 and CRY2 in a ligand-dependent fashion. Interacts with CIART. Interacts with RWDD3. Interacts with UBE2I/UBC9 and this interaction is enhanced in the presence of RWDD3. Interacts with GRIP1. Interacts with NR4A3 (via nuclear receptor DNA-binding domain), represses transcription activity of NR4A3 on the POMC promoter Nur response element (NurRE). Directly interacts with PNRC2 to attract and form a complex with UPF1 and DCP1A; the interaction leads to rapid mRNA degradation. Interacts with GSK3B. Interacts with FNIP1 and FNIP2. Interacts (via C-terminus) with HNRNPU (via C-terminus). Interacts with MCM3AP (By similarity). Interacts (via domain NR LBD) with HSP90AA1 and HSP90AB1 (By similarity). In the absence of hormonal ligand, interacts with TACC1 (By similarity). Interacts (via NR LBD domain) with ZNF764 (via KRAB domain); the interaction regulates transcription factor activity of NR3C1 by directing its actions toward certain biologic pathways (By similarity).|||Increased proteasome-mediated degradation in response to glucocorticoids.|||Mitochondrion|||Nucleus|||Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoid. The Ser-203, Ser-226 and Ser-404-phosphorylated forms are mainly cytoplasmic, and the Ser-211-phosphorylated form is nuclear. Phosphorylation at Ser-211 increases transcriptional activity. Phosphorylation at Ser-203, Ser-226 and Ser-404 decreases signaling capacity. Phosphorylation at Ser-404 may protect from glucocorticoid-induced apoptosis. Phosphorylation at Ser-203 and Ser-211 is not required in regulation of chromosome segregation. May be dephosphorylated by PPP5C, attenuates NR3C1 action.|||Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Mediates glucocorticoid-induced apoptosis. Promotes accurate chromosome segregation during mitosis. May act as a tumor suppressor. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression.|||Sumoylation at Lys-277 and Lys-293 negatively regulates its transcriptional activity. Sumoylation at Lys-703 positively regulates its transcriptional activity in the presence of RWDD3. Sumoylation at Lys-277 and Lys-293 is dispensable whereas sumoylation at Lys-703 is critical for the stimulatory effect of RWDD3 on its transcriptional activity. Heat shock increases sumoylation in a RWDD3-dependent manner.|||Ubiquitinated; restricts glucocorticoid-mediated transcriptional signaling.|||Within the infant and adult hippocampal formation, highest expression observed in the DG granule cell layer with moderate levels in the DG hilus, the CA2-CA4 pyramidal cell layer and the proximal part of the CA1 pyramidal cell layer. Moderate to high expression levels found in the presubiculum and in its' superficial layers. Weak but specific expression detected throughout the entire corticle mantle. In the amygdala, moderate levels were detected in the lateral, central and medial nuclei. Moderate expression levels were present in the PVNh alongside the third ventricle.|||centrosome|||spindle http://togogenome.org/gene/9483:LALBA ^@ http://purl.uniprot.org/uniprot/F7I977 ^@ Function|||Similarity ^@ Belongs to the glycosyl hydrolase 22 family.|||Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins. http://togogenome.org/gene/9483:LOC100400731 ^@ http://purl.uniprot.org/uniprot/A0A5F4WDC2 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/9483:RPF2 ^@ http://purl.uniprot.org/uniprot/U3DYQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RPF2 family.|||nucleolus http://togogenome.org/gene/9483:ADGRF5 ^@ http://purl.uniprot.org/uniprot/U3DDZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Membrane http://togogenome.org/gene/9483:DHODH ^@ http://purl.uniprot.org/uniprot/F7GU02 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:GPR137C ^@ http://purl.uniprot.org/uniprot/F6UCN2 ^@ Subcellular Location Annotation ^@ Lysosome membrane|||Membrane http://togogenome.org/gene/9483:SCAMP3 ^@ http://purl.uniprot.org/uniprot/F7GGH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/9483:DUSP13 ^@ http://purl.uniprot.org/uniprot/A0A5F4WAP2 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9483:CHRNE ^@ http://purl.uniprot.org/uniprot/F6QPL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9483:ATG3 ^@ http://purl.uniprot.org/uniprot/U3BCW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG3 family.|||Cytoplasm http://togogenome.org/gene/9483:LOC100415579 ^@ http://purl.uniprot.org/uniprot/F6V6V9 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9483:HABP4 ^@ http://purl.uniprot.org/uniprot/A0A5F4WJU0 ^@ Similarity ^@ Belongs to the SERBP1-HABP4 family. http://togogenome.org/gene/9483:HHIP ^@ http://purl.uniprot.org/uniprot/F6UZU3|||http://purl.uniprot.org/uniprot/U3FQI0 ^@ Caution|||Similarity ^@ Belongs to the HHIP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:RSPO1 ^@ http://purl.uniprot.org/uniprot/F7H9I5 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/9483:BTBD3 ^@ http://purl.uniprot.org/uniprot/F7ASZ0 ^@ Function|||Subcellular Location Annotation|||Tissue Specificity ^@ Acts as a key regulator of dendritic field orientation during development of sensory cortex. Also directs dendrites toward active axon terminals when ectopically expressed (By similarity).|||Nucleus|||Strongly expressed in the primary visual cortex.|||cytosol http://togogenome.org/gene/9483:PGLS ^@ http://purl.uniprot.org/uniprot/F6ZGY9 ^@ Function|||Similarity ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.|||Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. http://togogenome.org/gene/9483:NBN ^@ http://purl.uniprot.org/uniprot/U3EK58 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.|||Component of the MRN complex.|||Nucleus|||telomere http://togogenome.org/gene/9483:GIMD1 ^@ http://purl.uniprot.org/uniprot/F7IRN2 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9483:GNGT2 ^@ http://purl.uniprot.org/uniprot/F6UVS8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9483:SNX17 ^@ http://purl.uniprot.org/uniprot/F7IBA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane|||Early endosome|||Endosome|||Membrane http://togogenome.org/gene/9483:NUP35 ^@ http://purl.uniprot.org/uniprot/U3EEJ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Nup35 family.|||Functions as a component of the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/9483:HSPB1 ^@ http://purl.uniprot.org/uniprot/F7I2I3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Nucleus|||spindle http://togogenome.org/gene/9483:PPP2CB ^@ http://purl.uniprot.org/uniprot/F6XZ20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/9483:GPX8 ^@ http://purl.uniprot.org/uniprot/F7ISV1 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/9483:RPL19 ^@ http://purl.uniprot.org/uniprot/F7EZL4 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/9483:TMEM218 ^@ http://purl.uniprot.org/uniprot/F6X530 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM218 family.|||May be involved in ciliary biogenesis or function.|||Membrane|||cilium http://togogenome.org/gene/9483:DNM3 ^@ http://purl.uniprot.org/uniprot/F7HY82|||http://purl.uniprot.org/uniprot/U3EHX9 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/9483:ENTPD4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XFF4|||http://purl.uniprot.org/uniprot/F6YYY9 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9483:CLCA4 ^@ http://purl.uniprot.org/uniprot/F7CCL6 ^@ Similarity ^@ Belongs to the CLCR family. http://togogenome.org/gene/9483:TMEM161B ^@ http://purl.uniprot.org/uniprot/U3FR05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM161 family.|||Membrane http://togogenome.org/gene/9483:CD14 ^@ http://purl.uniprot.org/uniprot/F7B9N7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Interacts with LPAR1.|||Cell membrane|||Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).|||Golgi apparatus|||Membrane raft|||Secreted http://togogenome.org/gene/9483:ZRANB2 ^@ http://purl.uniprot.org/uniprot/U3E0L4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZRANB2 family.|||Nucleus|||Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection. http://togogenome.org/gene/9483:BAMBI ^@ http://purl.uniprot.org/uniprot/F7GN88 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BAMBI family.|||Membrane|||Negatively regulates TGF-beta signaling. http://togogenome.org/gene/9483:NSRP1 ^@ http://purl.uniprot.org/uniprot/A0A8I3W236|||http://purl.uniprot.org/uniprot/F6YHK4 ^@ Similarity ^@ Belongs to the NSRP1 family. http://togogenome.org/gene/9483:ROMO1 ^@ http://purl.uniprot.org/uniprot/B0KWM6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGR2 family.|||Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.|||Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:ATOH7 ^@ http://purl.uniprot.org/uniprot/A0A2R8NEN1 ^@ Subcellular Location Annotation ^@ Nucleus|||Perikaryon|||axon http://togogenome.org/gene/9483:PHOSPHO2 ^@ http://purl.uniprot.org/uniprot/F7HDN3 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. PHOSPHO family. http://togogenome.org/gene/9483:CD3E ^@ http://purl.uniprot.org/uniprot/Q3LRP4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:ELAPOR2 ^@ http://purl.uniprot.org/uniprot/A0A8I3W3Z1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELAPOR family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:CLDN10 ^@ http://purl.uniprot.org/uniprot/U3DXA8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9483:SEC61B ^@ http://purl.uniprot.org/uniprot/F7GQT6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC61-beta family.|||Endoplasmic reticulum membrane|||Membrane|||Necessary for protein translocation in the endoplasmic reticulum. http://togogenome.org/gene/9483:LOC100396215 ^@ http://purl.uniprot.org/uniprot/F7IT65 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:KRT3 ^@ http://purl.uniprot.org/uniprot/L7N0W8 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9483:PARP9 ^@ http://purl.uniprot.org/uniprot/F7IBF8|||http://purl.uniprot.org/uniprot/U3DWP6 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9483:PMCH ^@ http://purl.uniprot.org/uniprot/U3E078 ^@ Similarity ^@ Belongs to the melanin-concentrating hormone family. http://togogenome.org/gene/9483:RP2 ^@ http://purl.uniprot.org/uniprot/F6ZU00 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.|||Belongs to the TBCC family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:CERS2 ^@ http://purl.uniprot.org/uniprot/U3F4E2 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9483:CCDC85A ^@ http://purl.uniprot.org/uniprot/A0A8I3W9K1|||http://purl.uniprot.org/uniprot/A0A8I3WLT9|||http://purl.uniprot.org/uniprot/F7I9W1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC85 family.|||adherens junction http://togogenome.org/gene/9483:MTX2 ^@ http://purl.uniprot.org/uniprot/A0A5F4WBC3|||http://purl.uniprot.org/uniprot/U3ECU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metaxin family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9483:TAF1D ^@ http://purl.uniprot.org/uniprot/U3DRE0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF.|||Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.|||Nucleus http://togogenome.org/gene/9483:MYOG ^@ http://purl.uniprot.org/uniprot/F7IP79 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:AMACR ^@ http://purl.uniprot.org/uniprot/F7I3Q5 ^@ Similarity ^@ Belongs to the CoA-transferase III family. http://togogenome.org/gene/9483:MPP2 ^@ http://purl.uniprot.org/uniprot/F6TFU1 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/9483:MAT1A ^@ http://purl.uniprot.org/uniprot/F7DH88 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/9483:LOC100402272 ^@ http://purl.uniprot.org/uniprot/A0A8I3WVE3 ^@ Similarity ^@ Belongs to the cystatin family. http://togogenome.org/gene/9483:RPL3 ^@ http://purl.uniprot.org/uniprot/H9KX67 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/9483:PPP6R1 ^@ http://purl.uniprot.org/uniprot/U3F4F5 ^@ Similarity ^@ Belongs to the SAPS family. http://togogenome.org/gene/9483:EFNA1 ^@ http://purl.uniprot.org/uniprot/F7AMD6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:CTBS ^@ http://purl.uniprot.org/uniprot/U3CS40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 18 family.|||Lysosome http://togogenome.org/gene/9483:PFN2 ^@ http://purl.uniprot.org/uniprot/U3BGM3|||http://purl.uniprot.org/uniprot/U3CT70 ^@ Similarity ^@ Belongs to the profilin family. http://togogenome.org/gene/9483:ACOD1 ^@ http://purl.uniprot.org/uniprot/F7FT06 ^@ Similarity ^@ Belongs to the PrpD family. http://togogenome.org/gene/9483:VPS51 ^@ http://purl.uniprot.org/uniprot/F7CJS3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VPS51 family.|||Component of the Golgi-associated retrograde protein (GARP) complex. Component of the endosome-associated retrograde protein (EARP) complex.|||Endosome|||Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling.|||Recycling endosome|||trans-Golgi network http://togogenome.org/gene/9483:NACC2 ^@ http://purl.uniprot.org/uniprot/F6SRF1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:TMEM50A ^@ http://purl.uniprot.org/uniprot/F7IKB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane http://togogenome.org/gene/9483:IL18 ^@ http://purl.uniprot.org/uniprot/U3CWC9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Cytoplasm|||Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.|||Secreted http://togogenome.org/gene/9483:ELL2 ^@ http://purl.uniprot.org/uniprot/A0A8I3WES2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Nucleus http://togogenome.org/gene/9483:TXLNB ^@ http://purl.uniprot.org/uniprot/U3DG24 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/9483:HSD17B11 ^@ http://purl.uniprot.org/uniprot/U3DLT9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9483:LOC100390849 ^@ http://purl.uniprot.org/uniprot/U3B2I5 ^@ Similarity ^@ Belongs to the GroES chaperonin family. http://togogenome.org/gene/9483:SAR1B ^@ http://purl.uniprot.org/uniprot/F7IHI6 ^@ Similarity ^@ Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/9483:LOC100409753 ^@ http://purl.uniprot.org/uniprot/A0A2R8M4T8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/9483:OAT ^@ http://purl.uniprot.org/uniprot/U3FT89 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9483:DDX3Y ^@ http://purl.uniprot.org/uniprot/B8YDY8 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9483:LIX1L ^@ http://purl.uniprot.org/uniprot/U3B1X1 ^@ Similarity ^@ Belongs to the LIX1 family. http://togogenome.org/gene/9483:AFG3L2 ^@ http://purl.uniprot.org/uniprot/F7I3C6 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/9483:LONP2 ^@ http://purl.uniprot.org/uniprot/A0A5F4VY50|||http://purl.uniprot.org/uniprot/A0A5F4W7F5|||http://purl.uniprot.org/uniprot/U3CTR9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.|||Belongs to the peptidase S16 family.|||Interacts with PEX5. Interacts with TYSND1.|||Peroxisome matrix http://togogenome.org/gene/9483:CALHM5 ^@ http://purl.uniprot.org/uniprot/F7IPZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9483:CHMP1A ^@ http://purl.uniprot.org/uniprot/A0A8I3XAU1 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9483:SKP1 ^@ http://purl.uniprot.org/uniprot/U3CKA4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SKP1 family.|||Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit.|||Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1.|||The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. http://togogenome.org/gene/9483:ANKRD13C ^@ http://purl.uniprot.org/uniprot/U3F703 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:LOC100409067 ^@ http://purl.uniprot.org/uniprot/A0A8I4A5K5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9483:DEGS1 ^@ http://purl.uniprot.org/uniprot/F7IN61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:BEX4 ^@ http://purl.uniprot.org/uniprot/F7H6P0 ^@ Similarity ^@ Belongs to the BEX family. http://togogenome.org/gene/9483:ARSI ^@ http://purl.uniprot.org/uniprot/A0A2R8NEX2 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9483:TNFSF10 ^@ http://purl.uniprot.org/uniprot/F7E747 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Homotrimer.|||Membrane|||Secreted http://togogenome.org/gene/9483:ELP4 ^@ http://purl.uniprot.org/uniprot/F7IDJ9|||http://purl.uniprot.org/uniprot/U3C5B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELP4 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:AHSA1 ^@ http://purl.uniprot.org/uniprot/A0A2R8N8T2 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/9483:SERF1A ^@ http://purl.uniprot.org/uniprot/F6SEZ1 ^@ Similarity ^@ Belongs to the SERF family. http://togogenome.org/gene/9483:CDX4 ^@ http://purl.uniprot.org/uniprot/H9KWU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Caudal homeobox family.|||Nucleus http://togogenome.org/gene/9483:B3GALNT1 ^@ http://purl.uniprot.org/uniprot/F6XVE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:ANP32E ^@ http://purl.uniprot.org/uniprot/F7HKP3|||http://purl.uniprot.org/uniprot/F7IR97 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANP32 family.|||Multifunctional protein that is involved in the regulation of many processes.|||Nucleus http://togogenome.org/gene/9483:IQCD ^@ http://purl.uniprot.org/uniprot/F7DQE6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC10 family.|||Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.|||flagellum axoneme http://togogenome.org/gene/9483:L3MBTL3 ^@ http://purl.uniprot.org/uniprot/F7I9N0|||http://purl.uniprot.org/uniprot/U3D1Y4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:SLC35D1 ^@ http://purl.uniprot.org/uniprot/F7HHN3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:GNS ^@ http://purl.uniprot.org/uniprot/F7ENH2 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Lysosome|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9483:SPADH ^@ http://purl.uniprot.org/uniprot/A0A5F4W1L2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:NAF1 ^@ http://purl.uniprot.org/uniprot/A0A8I3WD50|||http://purl.uniprot.org/uniprot/U3FIR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAF1 family.|||Nucleus http://togogenome.org/gene/9483:ST3GAL3 ^@ http://purl.uniprot.org/uniprot/U3FXU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9483:HIGD2A ^@ http://purl.uniprot.org/uniprot/F7IAW2 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/9483:KIF3B ^@ http://purl.uniprot.org/uniprot/F7IBN6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9483:MGAT1 ^@ http://purl.uniprot.org/uniprot/F7I3E4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 13 family.|||Golgi apparatus membrane|||Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.|||Membrane|||The cofactor is mostly bound to the substrate. http://togogenome.org/gene/9483:KDELR3 ^@ http://purl.uniprot.org/uniprot/U3CH29 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:LOC100391517 ^@ http://purl.uniprot.org/uniprot/F7DXB9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the actin family.|||Golgi apparatus|||May play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis.|||Nucleus|||cytoskeleton http://togogenome.org/gene/9483:RBX1 ^@ http://purl.uniprot.org/uniprot/F7IAL6 ^@ Similarity ^@ Belongs to the RING-box family. http://togogenome.org/gene/9483:VPS29 ^@ http://purl.uniprot.org/uniprot/F7HLW3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.|||Belongs to the VPS29 family.|||Endosome membrane http://togogenome.org/gene/9483:EEF1A1 ^@ http://purl.uniprot.org/uniprot/A0A8I3VX86 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/9483:NPRL3 ^@ http://purl.uniprot.org/uniprot/B0VX74 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway.|||Belongs to the NPR3 family.|||Lysosome http://togogenome.org/gene/9483:PDCD11 ^@ http://purl.uniprot.org/uniprot/A0A5F4VWX1|||http://purl.uniprot.org/uniprot/F6R7C7 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9483:SLC30A6 ^@ http://purl.uniprot.org/uniprot/A0A8I3WIB8|||http://purl.uniprot.org/uniprot/F7ICS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin-binding proteins ADF family.|||Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9483:CSNK1G1 ^@ http://purl.uniprot.org/uniprot/A0A2R8MI70|||http://purl.uniprot.org/uniprot/A0A2R8MT47 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. http://togogenome.org/gene/9483:LOC100390879 ^@ http://purl.uniprot.org/uniprot/F7F510|||http://purl.uniprot.org/uniprot/U3CAP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. BCS1 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9483:RPS11 ^@ http://purl.uniprot.org/uniprot/F7EY42 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/9483:DCK ^@ http://purl.uniprot.org/uniprot/U3DGS6 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/9483:NIPA2 ^@ http://purl.uniprot.org/uniprot/F7DQD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9483:NEFM ^@ http://purl.uniprot.org/uniprot/A0A8I3WVA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intermediate filament family.|||axon http://togogenome.org/gene/9483:LOC100894890 ^@ http://purl.uniprot.org/uniprot/A0A8I3WJ75 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/9483:MRS2 ^@ http://purl.uniprot.org/uniprot/U3EQV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:CCDC25 ^@ http://purl.uniprot.org/uniprot/A0A5F4W7J6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CCDC25 family.|||Cell membrane|||Endomembrane system|||Interacts (via cytoplasmic region) with ILK. http://togogenome.org/gene/9483:LOC100410892 ^@ http://purl.uniprot.org/uniprot/B0KWQ2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BABAM1 family.|||Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1 and BABAM2. Component of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Identified in a complex with SHMT2 and the other subunits of the BRISC complex.|||Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination.|||Cytoplasm|||Nucleus|||The VWFA-like region is similar to the VWFA domain. Its presence reveals similarities between the structure of the 19S proteasome and the BRCA1-A complexes. http://togogenome.org/gene/9483:PDK3 ^@ http://purl.uniprot.org/uniprot/U3DT63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9483:SEMA3E ^@ http://purl.uniprot.org/uniprot/F7F565 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:PIWIL1 ^@ http://purl.uniprot.org/uniprot/F7GRR2 ^@ Similarity ^@ Belongs to the argonaute family. http://togogenome.org/gene/9483:MAPK1 ^@ http://purl.uniprot.org/uniprot/F7AKA7 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.|||caveola|||focal adhesion http://togogenome.org/gene/9483:LOC100895825 ^@ http://purl.uniprot.org/uniprot/F7H5R6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:POGLUT2 ^@ http://purl.uniprot.org/uniprot/F6ZGF8 ^@ Similarity ^@ Belongs to the KDELC family. http://togogenome.org/gene/9483:CLCF1 ^@ http://purl.uniprot.org/uniprot/A0A2R8MWL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-6 superfamily.|||Secreted http://togogenome.org/gene/9483:OR4C11 ^@ http://purl.uniprot.org/uniprot/A0A8I3WNC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:LOC100397481 ^@ http://purl.uniprot.org/uniprot/A0A2R8MZU2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/9483:TMEM41A ^@ http://purl.uniprot.org/uniprot/A0A2R8PDW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM41 family.|||Membrane http://togogenome.org/gene/9483:MAP3K8 ^@ http://purl.uniprot.org/uniprot/F7FA86 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/9483:HCN3 ^@ http://purl.uniprot.org/uniprot/F7ELT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel HCN family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:SGCB ^@ http://purl.uniprot.org/uniprot/F7IFJ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.|||Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/9483:SRPRB ^@ http://purl.uniprot.org/uniprot/A0A2R8PDK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP receptor beta subunit family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:NOG ^@ http://purl.uniprot.org/uniprot/U3FU84 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the noggin family.|||Homodimer.|||Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.|||Secreted http://togogenome.org/gene/9483:CKM ^@ http://purl.uniprot.org/uniprot/U3BQ10 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/9483:PDE5A ^@ http://purl.uniprot.org/uniprot/A0A2R8M2M9|||http://purl.uniprot.org/uniprot/A0A8I3X5J8|||http://purl.uniprot.org/uniprot/F7HKP9 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9483:HMX3 ^@ http://purl.uniprot.org/uniprot/A0A8I3XF10 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:PAXBP1 ^@ http://purl.uniprot.org/uniprot/B0VXG1 ^@ Similarity ^@ Belongs to the GCF family. http://togogenome.org/gene/9483:SIVA1 ^@ http://purl.uniprot.org/uniprot/U3FLH3 ^@ Function|||PTM|||Subcellular Location Annotation ^@ Cytoplasm|||Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.|||Nucleus|||Phosphorylated by ABL2/ARG in response to oxidative stress. http://togogenome.org/gene/9483:C13H18orf32 ^@ http://purl.uniprot.org/uniprot/F7I248 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UPF0729 family.|||Interacts with DERL1 and AMFR.|||Lipid droplet|||May activate the NF-kappa-B signaling pathway. http://togogenome.org/gene/9483:SYK ^@ http://purl.uniprot.org/uniprot/U3BGC5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily. http://togogenome.org/gene/9483:CTNNA2 ^@ http://purl.uniprot.org/uniprot/A0A2R8MPZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vinculin/alpha-catenin family.|||Cell membrane|||Membrane|||adherens junction http://togogenome.org/gene/9483:CALHM2 ^@ http://purl.uniprot.org/uniprot/F6QN32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9483:CRBN ^@ http://purl.uniprot.org/uniprot/U3FF41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRBN family.|||Nucleus http://togogenome.org/gene/9483:SLC30A9 ^@ http://purl.uniprot.org/uniprot/F7FLK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Endoplasmic reticulum|||Membrane|||Mitochondrion membrane|||Nucleus http://togogenome.org/gene/9483:CXCL12 ^@ http://purl.uniprot.org/uniprot/A0A8I3WCR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9483:PTGFR ^@ http://purl.uniprot.org/uniprot/A0A2R8MHU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:MCHR2 ^@ http://purl.uniprot.org/uniprot/F7I268 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:LOC103794843 ^@ http://purl.uniprot.org/uniprot/F7AHH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:MAPKAPK3 ^@ http://purl.uniprot.org/uniprot/U3CZ05 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:GNA13 ^@ http://purl.uniprot.org/uniprot/U3EV79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-alpha family. G(12) subfamily.|||Membrane http://togogenome.org/gene/9483:TENT5B ^@ http://purl.uniprot.org/uniprot/U3D7K2 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/9483:ATPAF2 ^@ http://purl.uniprot.org/uniprot/U3D1C4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP12 family.|||Mitochondrion http://togogenome.org/gene/9483:TTC19 ^@ http://purl.uniprot.org/uniprot/U3CQJ1 ^@ Similarity ^@ Belongs to the TTC19 family. http://togogenome.org/gene/9483:HLCS ^@ http://purl.uniprot.org/uniprot/U3BVA4 ^@ Similarity ^@ Belongs to the biotin--protein ligase family. http://togogenome.org/gene/9483:LOC103787296 ^@ http://purl.uniprot.org/uniprot/A0A1K0GY26 ^@ Function|||Similarity ^@ Belongs to the globin family.|||Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1. Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling. http://togogenome.org/gene/9483:CIAPIN1 ^@ http://purl.uniprot.org/uniprot/U3FXU7 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the anamorsin family.|||Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion intermembrane space|||Monomer. Interacts with NDOR1. Interacts with CHCHD4.|||Nucleus|||The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.|||The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.|||The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space. http://togogenome.org/gene/9483:HSPA4 ^@ http://purl.uniprot.org/uniprot/F7HTM4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 70 family.|||Cytoplasm|||Interacts with TJP1/ZO-1. http://togogenome.org/gene/9483:DPY19L4 ^@ http://purl.uniprot.org/uniprot/A0A8I3VVX1|||http://purl.uniprot.org/uniprot/F7GYW3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dpy-19 family.|||Membrane|||Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. http://togogenome.org/gene/9483:COX6A2 ^@ http://purl.uniprot.org/uniprot/F6VFX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 6A family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9483:ITFG1 ^@ http://purl.uniprot.org/uniprot/U3DWU5 ^@ Similarity ^@ Belongs to the TIP family. http://togogenome.org/gene/9483:ALPL ^@ http://purl.uniprot.org/uniprot/D0ECS6 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alkaline phosphatase family.|||Binds 1 Mg(2+) ion.|||Binds 2 Zn(2+) ions.|||Cell membrane|||Homodimer.|||Membrane http://togogenome.org/gene/9483:PRIM1 ^@ http://purl.uniprot.org/uniprot/F6Y809 ^@ Similarity ^@ Belongs to the eukaryotic-type primase small subunit family. http://togogenome.org/gene/9483:SNAP23 ^@ http://purl.uniprot.org/uniprot/H9KVX9|||http://purl.uniprot.org/uniprot/U3EQ25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP-25 family.|||Cell membrane|||Membrane|||synaptosome http://togogenome.org/gene/9483:DYNLT4 ^@ http://purl.uniprot.org/uniprot/A0A5F4W1Y7 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/9483:MARCHF4 ^@ http://purl.uniprot.org/uniprot/U3DXK9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:EPGN ^@ http://purl.uniprot.org/uniprot/F7G1N3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:KARS1 ^@ http://purl.uniprot.org/uniprot/F7I4R7|||http://purl.uniprot.org/uniprot/U3D440 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9483:SAP18 ^@ http://purl.uniprot.org/uniprot/F7IS86 ^@ Similarity ^@ Belongs to the SAP18 family. http://togogenome.org/gene/9483:SEC31A ^@ http://purl.uniprot.org/uniprot/U3DIC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC31 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9483:OR10A3 ^@ http://purl.uniprot.org/uniprot/A0A2R8MD97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:NELFE ^@ http://purl.uniprot.org/uniprot/U3BMY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM NELF-E family.|||Chromosome|||Nucleus http://togogenome.org/gene/9483:ZNF622 ^@ http://purl.uniprot.org/uniprot/U3FS90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the REI1 family.|||Cytoplasm http://togogenome.org/gene/9483:LOC100400584 ^@ http://purl.uniprot.org/uniprot/A0A5F4W1M1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:PRDM2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ML28|||http://purl.uniprot.org/uniprot/F7AGI5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:PPBP ^@ http://purl.uniprot.org/uniprot/F6WJ66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9483:CDK5RAP3 ^@ http://purl.uniprot.org/uniprot/F6UTR5 ^@ Similarity ^@ Belongs to the CDK5RAP3 family. http://togogenome.org/gene/9483:SDE2 ^@ http://purl.uniprot.org/uniprot/F7IKP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SDE2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:CPLANE2 ^@ http://purl.uniprot.org/uniprot/F7E9N3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.|||cilium basal body http://togogenome.org/gene/9483:ACOT8 ^@ http://purl.uniprot.org/uniprot/F7I0J8 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/9483:SCML4 ^@ http://purl.uniprot.org/uniprot/A0A8I3WF15 ^@ Similarity ^@ Belongs to the SCM family. http://togogenome.org/gene/9483:LOC100389598 ^@ http://purl.uniprot.org/uniprot/A0A8I3W4N9 ^@ Similarity|||Subunit ^@ Belongs to the GST superfamily. Theta family.|||Homodimer. http://togogenome.org/gene/9483:TAAR5 ^@ http://purl.uniprot.org/uniprot/D2X5Q7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9483:CA5B ^@ http://purl.uniprot.org/uniprot/F7A852 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9483:VEPH1 ^@ http://purl.uniprot.org/uniprot/U3B398 ^@ Similarity ^@ Belongs to the MELT/VEPH family. http://togogenome.org/gene/9483:CD38 ^@ http://purl.uniprot.org/uniprot/U3CHI9 ^@ Similarity ^@ Belongs to the ADP-ribosyl cyclase family. http://togogenome.org/gene/9483:RAD51D ^@ http://purl.uniprot.org/uniprot/A0A2R8MX66 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.|||Nucleus http://togogenome.org/gene/9483:MAP2K1 ^@ http://purl.uniprot.org/uniprot/U3CZR8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:YARS2 ^@ http://purl.uniprot.org/uniprot/F6T7V7 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9483:CENPI ^@ http://purl.uniprot.org/uniprot/F7IAQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-I/CTF3 family.|||Nucleus|||centromere http://togogenome.org/gene/9483:RASGRP2 ^@ http://purl.uniprot.org/uniprot/F7HIU6 ^@ Similarity ^@ Belongs to the RASGRP family. http://togogenome.org/gene/9483:KCNMB2 ^@ http://purl.uniprot.org/uniprot/F6PZE6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KCNMB (TC 8.A.14.1) family.|||Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.|||Membrane|||N-glycosylated.|||Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. http://togogenome.org/gene/9483:PCK1 ^@ http://purl.uniprot.org/uniprot/A0A2R8MHZ1 ^@ Similarity|||Subunit ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.|||Monomer. http://togogenome.org/gene/9483:ROM1 ^@ http://purl.uniprot.org/uniprot/F7IB94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRPH2/ROM1 family.|||Membrane http://togogenome.org/gene/9483:CCNH ^@ http://purl.uniprot.org/uniprot/A0A2R8MAZ6|||http://purl.uniprot.org/uniprot/A0A8J8Y8G9 ^@ Function|||Similarity|||Subunit ^@ Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.|||Belongs to the cyclin family. Cyclin C subfamily.|||Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. http://togogenome.org/gene/9483:MAP4K3 ^@ http://purl.uniprot.org/uniprot/F6XUW1|||http://purl.uniprot.org/uniprot/U3BDA4 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. http://togogenome.org/gene/9483:RPS5 ^@ http://purl.uniprot.org/uniprot/F6T2T8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS7 family. http://togogenome.org/gene/9483:GJB6 ^@ http://purl.uniprot.org/uniprot/F7IEX2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9483:ATP6V0D1 ^@ http://purl.uniprot.org/uniprot/F7HR82 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9483:APOE ^@ http://purl.uniprot.org/uniprot/U3FTG7 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/9483:TRIM38 ^@ http://purl.uniprot.org/uniprot/F7GAP3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRIM/RBCC family.|||Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:RABGGTB ^@ http://purl.uniprot.org/uniprot/F7H322 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit beta family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX. http://togogenome.org/gene/9483:YIPF5 ^@ http://purl.uniprot.org/uniprot/F7DBS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane http://togogenome.org/gene/9483:F3 ^@ http://purl.uniprot.org/uniprot/U3BFC1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tissue factor family.|||Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.|||Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII. http://togogenome.org/gene/9483:SMAD5 ^@ http://purl.uniprot.org/uniprot/U3FCQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:STAG3 ^@ http://purl.uniprot.org/uniprot/F6WTL9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||centromere http://togogenome.org/gene/9483:NDC80 ^@ http://purl.uniprot.org/uniprot/A0A5F4W8P7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the NDC80/HEC1 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/9483:TM4SF5 ^@ http://purl.uniprot.org/uniprot/F6YBC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9483:UCK2 ^@ http://purl.uniprot.org/uniprot/F7IAY5 ^@ Similarity ^@ Belongs to the uridine kinase family. http://togogenome.org/gene/9483:CPT1A ^@ http://purl.uniprot.org/uniprot/U3DBW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the carnitine/choline acetyltransferase family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9483:MEOX2 ^@ http://purl.uniprot.org/uniprot/F6YFS8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:ZDHHC6 ^@ http://purl.uniprot.org/uniprot/U3CJD2 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Endoplasmic reticulum membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9483:GMPR2 ^@ http://purl.uniprot.org/uniprot/F6SDX3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.|||Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.|||Homotetramer. http://togogenome.org/gene/9483:GPRIN1 ^@ http://purl.uniprot.org/uniprot/F7CTE5 ^@ Function ^@ May be involved in neurite outgrowth. http://togogenome.org/gene/9483:GOLM2 ^@ http://purl.uniprot.org/uniprot/F6W961|||http://purl.uniprot.org/uniprot/U3BZS1|||http://purl.uniprot.org/uniprot/U3E483 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLM family.|||Membrane http://togogenome.org/gene/9483:CD5L ^@ http://purl.uniprot.org/uniprot/F7HDX2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:SAA1 ^@ http://purl.uniprot.org/uniprot/U3DW52 ^@ Function|||Similarity ^@ Belongs to the SAA family.|||Major acute phase reactant. Apolipoprotein of the HDL complex. http://togogenome.org/gene/9483:MAPK13 ^@ http://purl.uniprot.org/uniprot/U3BML8 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Interacts with MAPK8IP2. http://togogenome.org/gene/9483:DLL3 ^@ http://purl.uniprot.org/uniprot/F7INL2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:NIPBL ^@ http://purl.uniprot.org/uniprot/U3D5P8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCC2/Nipped-B family.|||Nucleus http://togogenome.org/gene/9483:PDP1 ^@ http://purl.uniprot.org/uniprot/F7E6B2 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9483:CMTM6 ^@ http://purl.uniprot.org/uniprot/F6RXA3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:TOLLIP ^@ http://purl.uniprot.org/uniprot/F6PGK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tollip family.|||Cytoplasm http://togogenome.org/gene/9483:DIDO1 ^@ http://purl.uniprot.org/uniprot/U3C3N8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:ACMSD ^@ http://purl.uniprot.org/uniprot/F6RC97|||http://purl.uniprot.org/uniprot/F6RCM1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.|||Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.|||Monomer. http://togogenome.org/gene/9483:MED1 ^@ http://purl.uniprot.org/uniprot/U3EHB1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 1 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/9483:SULT1E1 ^@ http://purl.uniprot.org/uniprot/A0A7G3QSE2 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9483:ZC3HC1 ^@ http://purl.uniprot.org/uniprot/F6T351 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:TGM7 ^@ http://purl.uniprot.org/uniprot/F7ICD6 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9483:ARPC4 ^@ http://purl.uniprot.org/uniprot/A0A5F4W208 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARPC4 family.|||Cell projection http://togogenome.org/gene/9483:DCTN2 ^@ http://purl.uniprot.org/uniprot/U3FJH5 ^@ Similarity ^@ Belongs to the dynactin subunit 2 family. http://togogenome.org/gene/9483:PSEN1 ^@ http://purl.uniprot.org/uniprot/U3D8G5|||http://purl.uniprot.org/uniprot/U3E9M1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A22A family.|||Cytoplasmic granule|||Early endosome membrane|||Endoplasmic reticulum membrane|||Endosome membrane|||Golgi apparatus membrane|||Homodimer.|||Membrane|||Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.|||Synapse|||The PAL motif is required for normal active site conformation.|||axon|||neuron projection http://togogenome.org/gene/9483:GALNT3 ^@ http://purl.uniprot.org/uniprot/F7I6A1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:LOC100385358 ^@ http://purl.uniprot.org/uniprot/U3FGA5 ^@ Similarity|||Subunit ^@ Belongs to the GST superfamily. Mu family.|||Homodimer. http://togogenome.org/gene/9483:CARNMT1 ^@ http://purl.uniprot.org/uniprot/F6VKA5 ^@ Similarity ^@ Belongs to the carnosine N-methyltransferase family. http://togogenome.org/gene/9483:NIM1K ^@ http://purl.uniprot.org/uniprot/F7HK05 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:NMT1 ^@ http://purl.uniprot.org/uniprot/U3FB93 ^@ Function|||Similarity ^@ Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.|||Belongs to the NMT family. http://togogenome.org/gene/9483:CFAP126 ^@ http://purl.uniprot.org/uniprot/F7IFB9 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the Flattop family. http://togogenome.org/gene/9483:HMBOX1 ^@ http://purl.uniprot.org/uniprot/F6W5X9|||http://purl.uniprot.org/uniprot/F6WQ92|||http://purl.uniprot.org/uniprot/U3BNX7|||http://purl.uniprot.org/uniprot/U3DHA5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:LOC100390645 ^@ http://purl.uniprot.org/uniprot/F7IA43 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9483:GJB3 ^@ http://purl.uniprot.org/uniprot/F6VAQ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9483:B3GNT3 ^@ http://purl.uniprot.org/uniprot/A0A2R8M6V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:TUFM ^@ http://purl.uniprot.org/uniprot/F7IMS0 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/9483:HDAC3 ^@ http://purl.uniprot.org/uniprot/F6RM17 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.|||Nucleus http://togogenome.org/gene/9483:TCN1 ^@ http://purl.uniprot.org/uniprot/F7GX30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic cobalamin transport proteins family.|||Secreted http://togogenome.org/gene/9483:DDX59 ^@ http://purl.uniprot.org/uniprot/U3EVA9 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX59 subfamily. http://togogenome.org/gene/9483:UNC119 ^@ http://purl.uniprot.org/uniprot/F7IB75 ^@ Similarity ^@ Belongs to the PDE6D/unc-119 family. http://togogenome.org/gene/9483:STX5 ^@ http://purl.uniprot.org/uniprot/F7AH00 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9483:LOC108591413 ^@ http://purl.uniprot.org/uniprot/F7GWA8 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9483:EXOC1 ^@ http://purl.uniprot.org/uniprot/A0A2R8MK81|||http://purl.uniprot.org/uniprot/F6TDJ1|||http://purl.uniprot.org/uniprot/U3BV40|||http://purl.uniprot.org/uniprot/U3DVK3|||http://purl.uniprot.org/uniprot/U3FIW4 ^@ Similarity ^@ Belongs to the SEC3 family. http://togogenome.org/gene/9483:TGFB3 ^@ http://purl.uniprot.org/uniprot/F7IQT4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.|||extracellular matrix http://togogenome.org/gene/9483:FAM13A ^@ http://purl.uniprot.org/uniprot/F7EXT0|||http://purl.uniprot.org/uniprot/F7FR29|||http://purl.uniprot.org/uniprot/F7G2B1|||http://purl.uniprot.org/uniprot/U3FMN3 ^@ Similarity ^@ Belongs to the FAM13 family. http://togogenome.org/gene/9483:MRPL54 ^@ http://purl.uniprot.org/uniprot/F7GZG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL54 family.|||Mitochondrion http://togogenome.org/gene/9483:LOC100412773 ^@ http://purl.uniprot.org/uniprot/A0A8I3X205 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:CLDN6 ^@ http://purl.uniprot.org/uniprot/U3E0Z7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9483:LOC100415168 ^@ http://purl.uniprot.org/uniprot/A0A2R8MPB4 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9483:LHFPL2 ^@ http://purl.uniprot.org/uniprot/A0A8I3WQE4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:BASP1 ^@ http://purl.uniprot.org/uniprot/F6PRD3 ^@ Similarity ^@ Belongs to the BASP1 family. http://togogenome.org/gene/9483:TRIP12 ^@ http://purl.uniprot.org/uniprot/A0A8J8XHJ3|||http://purl.uniprot.org/uniprot/F7EIN3|||http://purl.uniprot.org/uniprot/U3EA63 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPL family. K-HECT subfamily.|||E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins.|||nucleoplasm http://togogenome.org/gene/9483:LOC100896161 ^@ http://purl.uniprot.org/uniprot/F6VEW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:IL6ST ^@ http://purl.uniprot.org/uniprot/Q0GKF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/9483:LARS1 ^@ http://purl.uniprot.org/uniprot/U3D7F0 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9483:POSTN ^@ http://purl.uniprot.org/uniprot/A0A2R8PHI4|||http://purl.uniprot.org/uniprot/A0A8I4A2J5|||http://purl.uniprot.org/uniprot/F6R2K3|||http://purl.uniprot.org/uniprot/F6R2K9|||http://purl.uniprot.org/uniprot/F6RBY2|||http://purl.uniprot.org/uniprot/U3BT91|||http://purl.uniprot.org/uniprot/U3DGX9 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9483:MOK ^@ http://purl.uniprot.org/uniprot/A0A8I3WSD1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:GINS1 ^@ http://purl.uniprot.org/uniprot/U3EFA6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS1/PSF1 family.|||Chromosome|||Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex.|||Nucleus|||Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. http://togogenome.org/gene/9483:SLC30A4 ^@ http://purl.uniprot.org/uniprot/F7EZU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9483:EZH1 ^@ http://purl.uniprot.org/uniprot/U3EHI2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:MAP7 ^@ http://purl.uniprot.org/uniprot/F7GZT3|||http://purl.uniprot.org/uniprot/F7GZV8 ^@ Similarity ^@ Belongs to the MAP7 family. http://togogenome.org/gene/9483:GJA5 ^@ http://purl.uniprot.org/uniprot/A0A654IC83 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9483:HNRNPH2 ^@ http://purl.uniprot.org/uniprot/U3EAJ2 ^@ Subcellular Location Annotation ^@ nucleoplasm http://togogenome.org/gene/9483:B3GNT2 ^@ http://purl.uniprot.org/uniprot/F7DAC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:NAP1L4 ^@ http://purl.uniprot.org/uniprot/A0A5F4VVM7 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9483:DPT ^@ http://purl.uniprot.org/uniprot/U3E618 ^@ Similarity ^@ Belongs to the dermatopontin family. http://togogenome.org/gene/9483:FBLN7 ^@ http://purl.uniprot.org/uniprot/U3DR50 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:S100Z ^@ http://purl.uniprot.org/uniprot/A0A8I3WFT9 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9483:PRDX6 ^@ http://purl.uniprot.org/uniprot/F7ICM8 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/9483:CCT2 ^@ http://purl.uniprot.org/uniprot/A0A8I3WI23|||http://purl.uniprot.org/uniprot/U3FVV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9483:TSPAN9 ^@ http://purl.uniprot.org/uniprot/A0A8I3WP60|||http://purl.uniprot.org/uniprot/U3EI08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9483:GOSR1 ^@ http://purl.uniprot.org/uniprot/A0A8I3VZ75|||http://purl.uniprot.org/uniprot/F6WJ38|||http://purl.uniprot.org/uniprot/U3DM31 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GOSR1 family.|||Component of several multiprotein Golgi SNARE complexes.|||Golgi apparatus membrane|||Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.|||Membrane http://togogenome.org/gene/9483:MPP1 ^@ http://purl.uniprot.org/uniprot/B0KWU3 ^@ Function|||Subcellular Location Annotation ^@ Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity.|||stereocilium http://togogenome.org/gene/9483:FAM166C ^@ http://purl.uniprot.org/uniprot/U3BNZ1 ^@ Similarity ^@ Belongs to the CIMIP2 family. http://togogenome.org/gene/9483:METTL14 ^@ http://purl.uniprot.org/uniprot/A0A2R8NAC2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MT-A70-like family.|||Heterodimer; heterodimerizes with METTL3 to form an antiparallel heterodimer that constitutes an active methyltransferase.|||Nucleus|||The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation. In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization. M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis. M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells. http://togogenome.org/gene/9483:TMEM176B ^@ http://purl.uniprot.org/uniprot/U3CDT7 ^@ Similarity ^@ Belongs to the TMEM176 family. http://togogenome.org/gene/9483:ARRDC3 ^@ http://purl.uniprot.org/uniprot/A0A2R8MNN7 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9483:SLC7A11 ^@ http://purl.uniprot.org/uniprot/U3ENJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:SELP ^@ http://purl.uniprot.org/uniprot/A0A2R8MF93|||http://purl.uniprot.org/uniprot/A0A8I3WN67 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the selectin/LECAM family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:CXCL13 ^@ http://purl.uniprot.org/uniprot/A0A5F4WD53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9483:DMC1 ^@ http://purl.uniprot.org/uniprot/F6RJX1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. DMC1 subfamily.|||May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.|||Nucleus http://togogenome.org/gene/9483:SORCS3 ^@ http://purl.uniprot.org/uniprot/F6YYH9 ^@ Similarity ^@ Belongs to the VPS10-related sortilin family. SORCS subfamily. http://togogenome.org/gene/9483:TPRA1 ^@ http://purl.uniprot.org/uniprot/F6Y3P4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0359 family.|||Membrane http://togogenome.org/gene/9483:FOXB2 ^@ http://purl.uniprot.org/uniprot/A0A2R8MU65 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:CEP63 ^@ http://purl.uniprot.org/uniprot/F7I115|||http://purl.uniprot.org/uniprot/U3DNZ7 ^@ Similarity ^@ Belongs to the CEP63 family. http://togogenome.org/gene/9483:MOS ^@ http://purl.uniprot.org/uniprot/F7INI9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:PDGFRL ^@ http://purl.uniprot.org/uniprot/U3BFP6 ^@ Subunit ^@ Forms a complex composed of PDGFRL, TNK2 and GRB2. http://togogenome.org/gene/9483:TNFSF9 ^@ http://purl.uniprot.org/uniprot/F7CLT9 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9483:CALB1 ^@ http://purl.uniprot.org/uniprot/U3CTY1 ^@ Function|||Similarity ^@ Belongs to the calbindin family.|||Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. http://togogenome.org/gene/9483:PAX4 ^@ http://purl.uniprot.org/uniprot/B0VXF5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the paired homeobox family.|||Interacts with KDM5B.|||Nucleus|||Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs. http://togogenome.org/gene/9483:PHGDH ^@ http://purl.uniprot.org/uniprot/U3DVF2 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/9483:NCDN ^@ http://purl.uniprot.org/uniprot/U3BUT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the neurochondrin family.|||Postsynapse http://togogenome.org/gene/9483:CUL2 ^@ http://purl.uniprot.org/uniprot/F6SU62 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9483:TRAPPC1 ^@ http://purl.uniprot.org/uniprot/F7I3W8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/9483:D2HGDH ^@ http://purl.uniprot.org/uniprot/F7F4Q6 ^@ Similarity ^@ Belongs to the FAD-binding oxidoreductase/transferase type 4 family. http://togogenome.org/gene/9483:FOXR2 ^@ http://purl.uniprot.org/uniprot/A0A2R8M5S6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:BAP1 ^@ http://purl.uniprot.org/uniprot/F7GM69 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/9483:SYNDIG1L ^@ http://purl.uniprot.org/uniprot/F7HKE0 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9483:CTPS1 ^@ http://purl.uniprot.org/uniprot/F6SKL8 ^@ Function|||Similarity ^@ Belongs to the CTP synthase family.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. http://togogenome.org/gene/9483:IDNK ^@ http://purl.uniprot.org/uniprot/F7F3U9 ^@ Similarity ^@ Belongs to the gluconokinase GntK/GntV family. http://togogenome.org/gene/9483:AP1S2 ^@ http://purl.uniprot.org/uniprot/A0A2R8PC25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||Membrane|||clathrin-coated pit http://togogenome.org/gene/9483:DNAJC2 ^@ http://purl.uniprot.org/uniprot/U3F6A2 ^@ Function|||Subcellular Location Annotation ^@ Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation.|||Nucleus|||cytosol http://togogenome.org/gene/9483:SRXN1 ^@ http://purl.uniprot.org/uniprot/F7I4C5 ^@ Similarity ^@ Belongs to the sulfiredoxin family. http://togogenome.org/gene/9483:ADGRL3 ^@ http://purl.uniprot.org/uniprot/A0A2R8MM16|||http://purl.uniprot.org/uniprot/F7IQX7|||http://purl.uniprot.org/uniprot/F7IQX8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:YPEL3 ^@ http://purl.uniprot.org/uniprot/A0A2R8MGE5 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9483:ACTR6 ^@ http://purl.uniprot.org/uniprot/U3EAM1 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9483:SLC20A2 ^@ http://purl.uniprot.org/uniprot/F7I4B5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter. http://togogenome.org/gene/9483:SDHAF1 ^@ http://purl.uniprot.org/uniprot/A0A2R8M6Q6 ^@ Similarity ^@ Belongs to the complex I LYR family. SDHAF1 subfamily. http://togogenome.org/gene/9483:APOO ^@ http://purl.uniprot.org/uniprot/F7I3C9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:HINT1 ^@ http://purl.uniprot.org/uniprot/A0A2R8M646 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/9483:COX18 ^@ http://purl.uniprot.org/uniprot/U3BCA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OXA1/ALB3/YidC family.|||Membrane http://togogenome.org/gene/9483:SEPTIN9 ^@ http://purl.uniprot.org/uniprot/A0A8I3W584|||http://purl.uniprot.org/uniprot/F7GEF9|||http://purl.uniprot.org/uniprot/F7HJ35|||http://purl.uniprot.org/uniprot/F7HJ38 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/9483:NOP16 ^@ http://purl.uniprot.org/uniprot/F7I665 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP16 family.|||nucleolus http://togogenome.org/gene/9483:LIX1 ^@ http://purl.uniprot.org/uniprot/F7I554 ^@ Similarity ^@ Belongs to the LIX1 family. http://togogenome.org/gene/9483:CCL11 ^@ http://purl.uniprot.org/uniprot/F7I909 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9483:ENDOG ^@ http://purl.uniprot.org/uniprot/B0KWD9 ^@ Similarity ^@ Belongs to the DNA/RNA non-specific endonuclease family. http://togogenome.org/gene/9483:TOR4A ^@ http://purl.uniprot.org/uniprot/F7FEP2 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. Torsin subfamily. http://togogenome.org/gene/9483:ITK ^@ http://purl.uniprot.org/uniprot/F7IG16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cytoplasm http://togogenome.org/gene/9483:MRPL42 ^@ http://purl.uniprot.org/uniprot/U3FJI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL42 family.|||Mitochondrion http://togogenome.org/gene/9483:COQ3 ^@ http://purl.uniprot.org/uniprot/F7IL54 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Mitochondrion inner membrane|||O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. http://togogenome.org/gene/9483:PDF ^@ http://purl.uniprot.org/uniprot/U3EZZ0 ^@ Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. http://togogenome.org/gene/9483:ARRDC2 ^@ http://purl.uniprot.org/uniprot/F7BF58|||http://purl.uniprot.org/uniprot/F7BF67 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9483:EMP3 ^@ http://purl.uniprot.org/uniprot/F6PYE2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Probably involved in cell proliferation and cell-cell interactions. http://togogenome.org/gene/9483:MRPL44 ^@ http://purl.uniprot.org/uniprot/U3DQE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.|||Mitochondrion http://togogenome.org/gene/9483:SYNGR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8P6T3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptogyrin family.|||Membrane http://togogenome.org/gene/9483:ACTBL2 ^@ http://purl.uniprot.org/uniprot/A0A8I3WN26 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9483:SOX2 ^@ http://purl.uniprot.org/uniprot/F7H274 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:HSF2 ^@ http://purl.uniprot.org/uniprot/U3D7P6|||http://purl.uniprot.org/uniprot/U3D7X7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/9483:LOC100389040 ^@ http://purl.uniprot.org/uniprot/U3FDP9 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9483:CDH12 ^@ http://purl.uniprot.org/uniprot/U3EPZ9 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:BCL2L1 ^@ http://purl.uniprot.org/uniprot/F7IT36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Membrane|||Mitochondrion matrix|||Nucleus membrane|||centrosome|||cytosol|||synaptic vesicle membrane http://togogenome.org/gene/9483:WFDC12 ^@ http://purl.uniprot.org/uniprot/A4K2U1 ^@ Function|||Subcellular Location Annotation ^@ Antibacterial protein. Putative acid-stable proteinase inhibitor (By similarity).|||Secreted http://togogenome.org/gene/9483:NECTIN3 ^@ http://purl.uniprot.org/uniprot/U3B0A4 ^@ Similarity ^@ Belongs to the nectin family. http://togogenome.org/gene/9483:FAM98A ^@ http://purl.uniprot.org/uniprot/U3EAA8 ^@ Similarity ^@ Belongs to the FAM98 family. http://togogenome.org/gene/9483:PRRX1 ^@ http://purl.uniprot.org/uniprot/F7GR75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/9483:RNASEH2B ^@ http://purl.uniprot.org/uniprot/U3ERP0|||http://purl.uniprot.org/uniprot/U3FQM9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase H2 subunit B family.|||Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.|||Nucleus|||The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C. http://togogenome.org/gene/9483:H1-2 ^@ http://purl.uniprot.org/uniprot/U3EBN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9483:CTH ^@ http://purl.uniprot.org/uniprot/F7H0R1 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/9483:LPAR5 ^@ http://purl.uniprot.org/uniprot/F6XUY5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9483:FLVCR1 ^@ http://purl.uniprot.org/uniprot/F6W512 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:LOC100408124 ^@ http://purl.uniprot.org/uniprot/A0A8I3W279 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9483:CPEB1 ^@ http://purl.uniprot.org/uniprot/F7HRU4|||http://purl.uniprot.org/uniprot/U3FM09 ^@ Similarity ^@ Belongs to the RRM CPEB family. http://togogenome.org/gene/9483:NDUFAF4 ^@ http://purl.uniprot.org/uniprot/F7IGP2 ^@ Similarity|||Subunit ^@ Belongs to the NDUFAF4 family.|||Binds calmodulin. Interacts with NDUFAF3. http://togogenome.org/gene/9483:MED9 ^@ http://purl.uniprot.org/uniprot/F7C678 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 9 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9483:MRPL27 ^@ http://purl.uniprot.org/uniprot/F7IG40 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/9483:LOC100397154 ^@ http://purl.uniprot.org/uniprot/F6XRI6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uricase family.|||Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.|||Peroxisome http://togogenome.org/gene/9483:MX1 ^@ http://purl.uniprot.org/uniprot/U3EGN4 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/9483:SPOCK3 ^@ http://purl.uniprot.org/uniprot/F7HYW9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:HSDL1 ^@ http://purl.uniprot.org/uniprot/U3ARF3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9483:FUT4 ^@ http://purl.uniprot.org/uniprot/A0A8I3WR33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9483:OXTR ^@ http://purl.uniprot.org/uniprot/F7ILY7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane|||Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9483:MAGT1 ^@ http://purl.uniprot.org/uniprot/F7HX46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:ACAA2 ^@ http://purl.uniprot.org/uniprot/U3FQH9 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/9483:MDGA2 ^@ http://purl.uniprot.org/uniprot/U3DEF9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9483:SLC25A18 ^@ http://purl.uniprot.org/uniprot/U3DR59|||http://purl.uniprot.org/uniprot/U3E4V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9483:KDELR1 ^@ http://purl.uniprot.org/uniprot/U3BKM7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:GMDS ^@ http://purl.uniprot.org/uniprot/A0A2R8PJ06 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. http://togogenome.org/gene/9483:MRPS21 ^@ http://purl.uniprot.org/uniprot/F7HBX1 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/9483:CADM3 ^@ http://purl.uniprot.org/uniprot/F7D5S0|||http://purl.uniprot.org/uniprot/U3DTG8 ^@ Similarity ^@ Belongs to the nectin family. http://togogenome.org/gene/9483:SERINC3 ^@ http://purl.uniprot.org/uniprot/F7DZ63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9483:FUNDC1 ^@ http://purl.uniprot.org/uniprot/U3DRL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FUN14 family.|||Mitochondrion outer membrane http://togogenome.org/gene/9483:UBE2T ^@ http://purl.uniprot.org/uniprot/U3EFD1 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9483:SKIC2 ^@ http://purl.uniprot.org/uniprot/U3F5H6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:GJA1 ^@ http://purl.uniprot.org/uniprot/F6S7E5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Endoplasmic reticulum|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9483:CHD8 ^@ http://purl.uniprot.org/uniprot/A0A5K1TW24|||http://purl.uniprot.org/uniprot/A0A8J8XI99 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily.|||DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.|||Interacts with p53/TP53, histone H1, CTNNB1, CTCF and PIAS3. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with CHD7. Interacts with FAM124B.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Sumoylated. http://togogenome.org/gene/9483:AGK ^@ http://purl.uniprot.org/uniprot/U3CSI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AGK family.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/9483:SMIM18 ^@ http://purl.uniprot.org/uniprot/U3FM97 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:CAJA-DPA1 ^@ http://purl.uniprot.org/uniprot/A0A2R8MUF5 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/9483:AQP2 ^@ http://purl.uniprot.org/uniprot/F7H018 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9483:LOC100406481 ^@ http://purl.uniprot.org/uniprot/F7CVP1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCRH/QCR6 family.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:PLP2 ^@ http://purl.uniprot.org/uniprot/F6WQM2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:MASP1 ^@ http://purl.uniprot.org/uniprot/F6R2R9|||http://purl.uniprot.org/uniprot/U3EHF2|||http://purl.uniprot.org/uniprot/U3FSL2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9483:EPHB1 ^@ http://purl.uniprot.org/uniprot/U3EWE5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||dendrite http://togogenome.org/gene/9483:GAL ^@ http://purl.uniprot.org/uniprot/U3FCX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the galanin family.|||Secreted http://togogenome.org/gene/9483:INTS10 ^@ http://purl.uniprot.org/uniprot/A0A2R8PHP2|||http://purl.uniprot.org/uniprot/A0A5F4W2V6|||http://purl.uniprot.org/uniprot/U3EAM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 10 family.|||Nucleus http://togogenome.org/gene/9483:BCKDHA ^@ http://purl.uniprot.org/uniprot/U3DKQ5 ^@ Function|||Similarity ^@ Belongs to the BCKDHA family.|||Together with BCKDHB forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction. http://togogenome.org/gene/9483:IP6K1 ^@ http://purl.uniprot.org/uniprot/U3EJP7 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9483:CSMD1 ^@ http://purl.uniprot.org/uniprot/U3D3K9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:NFYA ^@ http://purl.uniprot.org/uniprot/F6PHK9|||http://purl.uniprot.org/uniprot/U3EB25 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NFYA/HAP2 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.|||Heterotrimer.|||Nucleus http://togogenome.org/gene/9483:HSCB ^@ http://purl.uniprot.org/uniprot/A0A2R8M6R9|||http://purl.uniprot.org/uniprot/A0A8I3WPU2 ^@ Similarity ^@ Belongs to the HscB family. http://togogenome.org/gene/9483:SSBP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8MT72 ^@ Subcellular Location Annotation ^@ mitochondrion nucleoid http://togogenome.org/gene/9483:PEA15 ^@ http://purl.uniprot.org/uniprot/F7ICU5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:INSIG1 ^@ http://purl.uniprot.org/uniprot/F6XME3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INSIG family.|||Endoplasmic reticulum membrane|||Mediates feedback control of cholesterol synthesis.|||Membrane http://togogenome.org/gene/9483:UQCRQ ^@ http://purl.uniprot.org/uniprot/F7FA82 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCRQ/QCR8 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9483:UGP2 ^@ http://purl.uniprot.org/uniprot/A0A8I3WLC0|||http://purl.uniprot.org/uniprot/F6QUM6|||http://purl.uniprot.org/uniprot/U3BG80 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDPGP type 1 family.|||Homooctamer.|||UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. http://togogenome.org/gene/9483:NEK6 ^@ http://purl.uniprot.org/uniprot/A0A8I3ZZ25 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:CCT4 ^@ http://purl.uniprot.org/uniprot/F7EYY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9483:KCNQ5 ^@ http://purl.uniprot.org/uniprot/U3DD98|||http://purl.uniprot.org/uniprot/U3DLN2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9483:DZIP3 ^@ http://purl.uniprot.org/uniprot/F7HI26 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:APOA4 ^@ http://purl.uniprot.org/uniprot/B0KWR0 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/9483:EBP ^@ http://purl.uniprot.org/uniprot/F7CM26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:CORO1C ^@ http://purl.uniprot.org/uniprot/U3BZ09 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/9483:OTX1 ^@ http://purl.uniprot.org/uniprot/F7GZ10 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:PDCD4 ^@ http://purl.uniprot.org/uniprot/U3BXK1 ^@ Similarity ^@ Belongs to the PDCD4 family. http://togogenome.org/gene/9483:PPAN ^@ http://purl.uniprot.org/uniprot/F7HMT1 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9483:MAPK9 ^@ http://purl.uniprot.org/uniprot/A0A2R8MHE7|||http://purl.uniprot.org/uniprot/U3CSF4|||http://purl.uniprot.org/uniprot/U3E7L6|||http://purl.uniprot.org/uniprot/U3EWQ9|||http://purl.uniprot.org/uniprot/U3F1Z7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/9483:HSD17B12 ^@ http://purl.uniprot.org/uniprot/F7DYP3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9483:ACTR3 ^@ http://purl.uniprot.org/uniprot/F7GST1 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9483:ARK2N ^@ http://purl.uniprot.org/uniprot/A0A8I4A5C2|||http://purl.uniprot.org/uniprot/U3EJW0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:BLCAP ^@ http://purl.uniprot.org/uniprot/F6XV20 ^@ Function|||Similarity ^@ Belongs to the BLCAP family.|||May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B. http://togogenome.org/gene/9483:HOGA1 ^@ http://purl.uniprot.org/uniprot/F7B5W8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the final step in the metabolic pathway of hydroxyproline.|||Homotetramer. http://togogenome.org/gene/9483:LPCAT4 ^@ http://purl.uniprot.org/uniprot/U3D5S4 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9483:ZSCAN29 ^@ http://purl.uniprot.org/uniprot/U3DM54 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9483:RTN4IP1 ^@ http://purl.uniprot.org/uniprot/F7IQ43 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/9483:ZDHHC12 ^@ http://purl.uniprot.org/uniprot/U3C6Y4 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9483:TRIM2 ^@ http://purl.uniprot.org/uniprot/U3DM64|||http://purl.uniprot.org/uniprot/U3F3S4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm http://togogenome.org/gene/9483:PEPD ^@ http://purl.uniprot.org/uniprot/F6V2W6|||http://purl.uniprot.org/uniprot/F6XAG3 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/9483:B3GNT6 ^@ http://purl.uniprot.org/uniprot/A0A2R8M8Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:LOC100409166 ^@ http://purl.uniprot.org/uniprot/F7I5Q9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/9483:MYC ^@ http://purl.uniprot.org/uniprot/P49032 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX (By similarity). Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated at Thr-58 and Ser-62) with FBXW7. Interacts with PIM2. Interacts with RIOX1. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity. Interacts with TRIM6 (By similarity). Interacts with NPM1; the binary complex is recruited to the promoter of MYC target genes and enhances their transcription (By similarity).|||Phosphorylated by PRKDC (By similarity). Phosphorylation at Ser-328 by PIM2 leads to the stabilization of MYC (By similarity). Phosphorylation at Ser-62 by CDK2 prevents Ras-induced senescence. Phosphorylated at Ser-62 by DYRK2; this primes the protein for subsequent phosphorylation by GSK3B at Thr-58. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome. Dephosphorylation at Ser-62 by protein phosphatase 2A (PPP2CA) promotes its degradation; interaction with PPP2CA is enhanced by AMBRA1 (By similarity).|||The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.|||Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (By similarity).|||Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. Ubiquitination is counteracted by USP28 in the nucleoplasm and USP36 in the nucleolus, both interacting with of FBXW7, leading to its deubiquitination and preventing degradation. Also polyubiquitinated by the DCX(TRPC4AP) complex. Ubiquitinated by TRIM6 in a phosphorylation-independent manner.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9483:TRIM63 ^@ http://purl.uniprot.org/uniprot/F7IA12 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:FMO1 ^@ http://purl.uniprot.org/uniprot/A0A221I096 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:A4GNT ^@ http://purl.uniprot.org/uniprot/F6Y451 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 32 family.|||Golgi apparatus membrane http://togogenome.org/gene/9483:PF4 ^@ http://purl.uniprot.org/uniprot/F6WJ19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9483:TMEM267 ^@ http://purl.uniprot.org/uniprot/U3FKE8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:SLC15A2 ^@ http://purl.uniprot.org/uniprot/F6YUC3|||http://purl.uniprot.org/uniprot/F7CVE6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Interacts (via extracellular domain region) with trypsin.|||Membrane http://togogenome.org/gene/9483:FAM187A ^@ http://purl.uniprot.org/uniprot/A0A5F4WC65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM187 family.|||Membrane http://togogenome.org/gene/9483:CADM2 ^@ http://purl.uniprot.org/uniprot/U3CI28 ^@ Similarity ^@ Belongs to the nectin family. http://togogenome.org/gene/9483:KREMEN1 ^@ http://purl.uniprot.org/uniprot/U3DHG7 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. http://togogenome.org/gene/9483:RARA ^@ http://purl.uniprot.org/uniprot/F6VKD1|||http://purl.uniprot.org/uniprot/F6WEA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9483:DUSP9 ^@ http://purl.uniprot.org/uniprot/A0A8J8XJC0 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9483:GRIK1 ^@ http://purl.uniprot.org/uniprot/A0A2R8MNS3|||http://purl.uniprot.org/uniprot/A0A2R8MRR1|||http://purl.uniprot.org/uniprot/A0A2R8MVG0|||http://purl.uniprot.org/uniprot/A0A2R8P6H5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9483:TRAPPC6A ^@ http://purl.uniprot.org/uniprot/U3EM73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||cis-Golgi network http://togogenome.org/gene/9483:RNASE1 ^@ http://purl.uniprot.org/uniprot/F7GJ91 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9483:ILKAP ^@ http://purl.uniprot.org/uniprot/U3FLN4 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9483:PNLIP ^@ http://purl.uniprot.org/uniprot/F7FR78 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9483:ADGRL4 ^@ http://purl.uniprot.org/uniprot/F7BJ41 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:GRPR ^@ http://purl.uniprot.org/uniprot/F6Z8A2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:FAM216B ^@ http://purl.uniprot.org/uniprot/A0A8I3WHX3 ^@ Similarity ^@ Belongs to the FAM216 family. http://togogenome.org/gene/9483:ZSCAN16 ^@ http://purl.uniprot.org/uniprot/F7IFE6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:HEPHL1 ^@ http://purl.uniprot.org/uniprot/F6RM70 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/9483:NUCB2 ^@ http://purl.uniprot.org/uniprot/F7IH71 ^@ Similarity ^@ Belongs to the nucleobindin family. http://togogenome.org/gene/9483:RAD54L2 ^@ http://purl.uniprot.org/uniprot/U3BCU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/9483:RFX3 ^@ http://purl.uniprot.org/uniprot/F7ESI7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:PITX2 ^@ http://purl.uniprot.org/uniprot/F6Q5G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9483:C3AR1 ^@ http://purl.uniprot.org/uniprot/F7IQB3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Interacts with VGF-derived peptide TLQP-21.|||Membrane|||Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. http://togogenome.org/gene/9483:CYP1A1 ^@ http://purl.uniprot.org/uniprot/F7DIB4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9483:EIF1B ^@ http://purl.uniprot.org/uniprot/F7G7W3 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/9483:TMEM35B ^@ http://purl.uniprot.org/uniprot/U3CP76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Membrane http://togogenome.org/gene/9483:CEP44 ^@ http://purl.uniprot.org/uniprot/A0A5F4WK08|||http://purl.uniprot.org/uniprot/U3EKX5 ^@ Subcellular Location Annotation ^@ Midbody|||centriole|||spindle pole http://togogenome.org/gene/9483:MMP16 ^@ http://purl.uniprot.org/uniprot/A0A2R8M760 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9483:SUPT3H ^@ http://purl.uniprot.org/uniprot/U3D6N9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:MCM6 ^@ http://purl.uniprot.org/uniprot/U3DPS8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/9483:MIS12 ^@ http://purl.uniprot.org/uniprot/F7EAN9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mis12 family.|||Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3, CBX5, NDC80 and ZWINT.|||kinetochore http://togogenome.org/gene/9483:SPACA4 ^@ http://purl.uniprot.org/uniprot/A0A5F4W347 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPACA4/bouncer family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:DDX55 ^@ http://purl.uniprot.org/uniprot/F7IR35 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9483:SUCLG1 ^@ http://purl.uniprot.org/uniprot/U3BBP8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).|||Mitochondrion|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. http://togogenome.org/gene/9483:DAP3 ^@ http://purl.uniprot.org/uniprot/U3EF11|||http://purl.uniprot.org/uniprot/U3EKP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS29 family.|||Mitochondrion http://togogenome.org/gene/9483:PNRC2 ^@ http://purl.uniprot.org/uniprot/U3FSE8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:TULP3 ^@ http://purl.uniprot.org/uniprot/U3E157 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TUB family.|||Secreted http://togogenome.org/gene/9483:CDK7 ^@ http://purl.uniprot.org/uniprot/F7IRE4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. http://togogenome.org/gene/9483:SSU72 ^@ http://purl.uniprot.org/uniprot/F7ETE9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SSU72 phosphatase family.|||Nucleus|||Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. http://togogenome.org/gene/9483:AGTR2 ^@ http://purl.uniprot.org/uniprot/F6Q2S1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MTUS1.|||Membrane http://togogenome.org/gene/9483:GNPNAT1 ^@ http://purl.uniprot.org/uniprot/F7CEE3 ^@ Similarity|||Subunit ^@ Belongs to the acetyltransferase family. GNA1 subfamily.|||Homodimer. http://togogenome.org/gene/9483:BRS3 ^@ http://purl.uniprot.org/uniprot/F7EPZ3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with C6orf89.|||Membrane http://togogenome.org/gene/9483:DLL1 ^@ http://purl.uniprot.org/uniprot/U3F3S0 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/9483:SLC1A4 ^@ http://purl.uniprot.org/uniprot/F7FQH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9483:WNT8B ^@ http://purl.uniprot.org/uniprot/A0A2R8M5J2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9483:MLF1 ^@ http://purl.uniprot.org/uniprot/U3CVU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MLF family.|||Cytoplasm http://togogenome.org/gene/9483:TTC9 ^@ http://purl.uniprot.org/uniprot/F7G5Z7 ^@ Similarity ^@ Belongs to the TTC9 family. http://togogenome.org/gene/9483:MALSU1 ^@ http://purl.uniprot.org/uniprot/F7I240 ^@ Similarity ^@ Belongs to the Iojap/RsfS family. http://togogenome.org/gene/9483:BYSL ^@ http://purl.uniprot.org/uniprot/F6XKE7 ^@ Similarity ^@ Belongs to the bystin family. http://togogenome.org/gene/9483:LOC108591274 ^@ http://purl.uniprot.org/uniprot/F7FDP2 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL31 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/9483:LOC100390666 ^@ http://purl.uniprot.org/uniprot/F7I248 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UPF0729 family.|||Interacts with DERL1 and AMFR.|||Lipid droplet|||May activate the NF-kappa-B signaling pathway. http://togogenome.org/gene/9483:DTD2 ^@ http://purl.uniprot.org/uniprot/F7CPR7 ^@ Similarity ^@ Belongs to the DTD family. http://togogenome.org/gene/9483:CBFA2T2 ^@ http://purl.uniprot.org/uniprot/U3C6N7 ^@ Similarity ^@ Belongs to the CBFA2T family. http://togogenome.org/gene/9483:BCAR1 ^@ http://purl.uniprot.org/uniprot/U3BL20|||http://purl.uniprot.org/uniprot/U3DHP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAS family.|||focal adhesion http://togogenome.org/gene/9483:GNG13 ^@ http://purl.uniprot.org/uniprot/A0A8I3X7B9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9483:STT3A ^@ http://purl.uniprot.org/uniprot/U3CCA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/9483:PTS ^@ http://purl.uniprot.org/uniprot/F7I609 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the PTPS family.|||Binds 1 zinc ion per subunit.|||Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. http://togogenome.org/gene/9483:LOC100406466 ^@ http://purl.uniprot.org/uniprot/A0A7R8C353 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9483:GRIK2 ^@ http://purl.uniprot.org/uniprot/F7IBF1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9483:RPL24 ^@ http://purl.uniprot.org/uniprot/F6PN21 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/9483:SVOP ^@ http://purl.uniprot.org/uniprot/U3DJI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/9483:IRAK4 ^@ http://purl.uniprot.org/uniprot/F6ZUT2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.|||Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.|||Cytoplasm|||Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. http://togogenome.org/gene/9483:JPT2 ^@ http://purl.uniprot.org/uniprot/U3FN87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:TAF8 ^@ http://purl.uniprot.org/uniprot/F6WY31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF8 family.|||Nucleus http://togogenome.org/gene/9483:GPX5 ^@ http://purl.uniprot.org/uniprot/F7I3U2 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/9483:RAB3IL1 ^@ http://purl.uniprot.org/uniprot/U3FS07 ^@ Similarity ^@ Belongs to the SEC2 family. http://togogenome.org/gene/9483:LSM1 ^@ http://purl.uniprot.org/uniprot/F7B4D2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Cytoplasm|||Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.|||P-body|||Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. http://togogenome.org/gene/9483:NGLY1 ^@ http://purl.uniprot.org/uniprot/F6PRJ8|||http://purl.uniprot.org/uniprot/F6TYG1|||http://purl.uniprot.org/uniprot/F7AI61 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transglutaminase-like superfamily. PNGase family.|||Cytoplasm|||Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins. http://togogenome.org/gene/9483:ACTA1 ^@ http://purl.uniprot.org/uniprot/F7FWZ0 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9483:SPI1 ^@ http://purl.uniprot.org/uniprot/U3D003|||http://purl.uniprot.org/uniprot/U3DY02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9483:SLC34A2 ^@ http://purl.uniprot.org/uniprot/F7F9F9 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the SLC34A transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:UBE2R2 ^@ http://purl.uniprot.org/uniprot/F7E9R9 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9483:KIF13A ^@ http://purl.uniprot.org/uniprot/A0A2R8MWV9|||http://purl.uniprot.org/uniprot/A0A2R8PC29|||http://purl.uniprot.org/uniprot/F6RG27|||http://purl.uniprot.org/uniprot/F6S2B2|||http://purl.uniprot.org/uniprot/U3EYE7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9483:NSG2 ^@ http://purl.uniprot.org/uniprot/U3CYN4 ^@ Similarity ^@ Belongs to the NSG family. http://togogenome.org/gene/9483:CPN1 ^@ http://purl.uniprot.org/uniprot/F7ICG5 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9483:SSTR3 ^@ http://purl.uniprot.org/uniprot/U3EF39 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9483:ACTR1B ^@ http://purl.uniprot.org/uniprot/U3FEU3 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9483:NAT9 ^@ http://purl.uniprot.org/uniprot/U3ECW1 ^@ Similarity ^@ Belongs to the acetyltransferase family. GNAT subfamily. http://togogenome.org/gene/9483:WNT10B ^@ http://purl.uniprot.org/uniprot/F7IIN7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9483:CYP7B1 ^@ http://purl.uniprot.org/uniprot/F6UDE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9483:HSPB3 ^@ http://purl.uniprot.org/uniprot/F7HVA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Nucleus http://togogenome.org/gene/9483:MAP1LC3A ^@ http://purl.uniprot.org/uniprot/F6QPF6 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9483:ATP2C2 ^@ http://purl.uniprot.org/uniprot/A0A5F4VXF5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:BMP2 ^@ http://purl.uniprot.org/uniprot/F7G4N4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/9483:SPINK4 ^@ http://purl.uniprot.org/uniprot/F7I1Z5 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9483:CHD7 ^@ http://purl.uniprot.org/uniprot/U3EHJ9 ^@ Similarity ^@ Belongs to the SNF2/RAD54 helicase family. http://togogenome.org/gene/9483:TMED7 ^@ http://purl.uniprot.org/uniprot/U3EUI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9483:TAS2R1 ^@ http://purl.uniprot.org/uniprot/A0A1C9ZNM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9483:PEMT ^@ http://purl.uniprot.org/uniprot/U3F8M0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.|||Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9483:ARSK ^@ http://purl.uniprot.org/uniprot/F7GPX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Lysosome http://togogenome.org/gene/9483:CEBPG ^@ http://purl.uniprot.org/uniprot/F7GML5 ^@ Similarity ^@ Belongs to the bZIP family. C/EBP subfamily. http://togogenome.org/gene/9483:UBE4A ^@ http://purl.uniprot.org/uniprot/U3AVF7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin conjugation factor E4 family.|||Cytoplasm|||The U-box domain is required for the ubiquitin protein ligase activity.|||Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. http://togogenome.org/gene/9483:GPBP1L1 ^@ http://purl.uniprot.org/uniprot/U3E0X3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vasculin family.|||Nucleus http://togogenome.org/gene/9483:THNSL2 ^@ http://purl.uniprot.org/uniprot/F6T1U5|||http://purl.uniprot.org/uniprot/U3AZV5 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/9483:IRF6 ^@ http://purl.uniprot.org/uniprot/F7E8C9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:BPNT2 ^@ http://purl.uniprot.org/uniprot/A0A5F4WL61|||http://purl.uniprot.org/uniprot/F6Y5S8|||http://purl.uniprot.org/uniprot/U3FL10 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inositol monophosphatase superfamily.|||Contains N-linked glycan resistant to endoglycosydase H.|||Exhibits 3'-nucleotidase activity toward adenosine 3',5'-bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate. May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, I(1,3,4)P3, I(1,4,5)P3 and I(1,3,4,5)P4.|||Golgi apparatus|||Strongly inhibited by lithium.|||trans-Golgi network membrane http://togogenome.org/gene/9483:AP3M2 ^@ http://purl.uniprot.org/uniprot/F7DPW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus http://togogenome.org/gene/9483:RPP14 ^@ http://purl.uniprot.org/uniprot/F6RR62 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family. http://togogenome.org/gene/9483:KIF5B ^@ http://purl.uniprot.org/uniprot/F6YJP5 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9483:LOC100413217 ^@ http://purl.uniprot.org/uniprot/F7FGL0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9483:GSTA4 ^@ http://purl.uniprot.org/uniprot/F7GQS8 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/9483:CKS2 ^@ http://purl.uniprot.org/uniprot/F7HV56 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.|||Forms a homohexamer that can probably bind six kinase subunits. http://togogenome.org/gene/9483:SNRPF ^@ http://purl.uniprot.org/uniprot/F6UZL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/9483:HAX1 ^@ http://purl.uniprot.org/uniprot/U3CV43 ^@ Function|||Similarity ^@ Belongs to the HAX1 family.|||Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. http://togogenome.org/gene/9483:ACTA2 ^@ http://purl.uniprot.org/uniprot/A0A8I3XF03 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9483:SLC25A12 ^@ http://purl.uniprot.org/uniprot/F7BXR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9483:AIMP2 ^@ http://purl.uniprot.org/uniprot/F7C5F2|||http://purl.uniprot.org/uniprot/U3FIK2 ^@ Subcellular Location Annotation ^@ Nucleus|||cytosol http://togogenome.org/gene/9483:AP4S1 ^@ http://purl.uniprot.org/uniprot/A0A2R8M2V0 ^@ Similarity ^@ Belongs to the adaptor complexes small subunit family. http://togogenome.org/gene/9483:BABAM2 ^@ http://purl.uniprot.org/uniprot/F7BJZ6|||http://purl.uniprot.org/uniprot/U3FDV6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BABAM2 family.|||Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.|||Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.|||Cytoplasm|||May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.|||Nucleus http://togogenome.org/gene/9483:KRT13 ^@ http://purl.uniprot.org/uniprot/F7AP91 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9483:GAPVD1 ^@ http://purl.uniprot.org/uniprot/U3DGI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GAPVD1 family.|||Membrane http://togogenome.org/gene/9483:OR2T10 ^@ http://purl.uniprot.org/uniprot/F7IFW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:OR2T27 ^@ http://purl.uniprot.org/uniprot/F7I327 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:OLFM2 ^@ http://purl.uniprot.org/uniprot/A0A2R8PDX8 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/9483:PEX2 ^@ http://purl.uniprot.org/uniprot/F6U7X0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pex2/pex10/pex12 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9483:CHST4 ^@ http://purl.uniprot.org/uniprot/F7HV48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/9483:SYT17 ^@ http://purl.uniprot.org/uniprot/F7HH86|||http://purl.uniprot.org/uniprot/U3ETE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Membrane http://togogenome.org/gene/9483:SRD5A3 ^@ http://purl.uniprot.org/uniprot/F6SQM7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).|||Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.|||Endoplasmic reticulum membrane|||Membrane|||Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. http://togogenome.org/gene/9483:ITM2C ^@ http://purl.uniprot.org/uniprot/F7A817|||http://purl.uniprot.org/uniprot/U3CUY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITM2 family.|||Membrane http://togogenome.org/gene/9483:TMSB10 ^@ http://purl.uniprot.org/uniprot/F7FGR8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/9483:C3H4orf47 ^@ http://purl.uniprot.org/uniprot/U3ECH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP96 family.|||centrosome http://togogenome.org/gene/9483:C9H12orf43 ^@ http://purl.uniprot.org/uniprot/U3EC11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUSTOS family.|||Nucleus envelope http://togogenome.org/gene/9483:GJA9 ^@ http://purl.uniprot.org/uniprot/F7CMI9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9483:SLC9A8 ^@ http://purl.uniprot.org/uniprot/F6PN51 ^@ Similarity ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. http://togogenome.org/gene/9483:AIF1 ^@ http://purl.uniprot.org/uniprot/U3D2H7 ^@ Subcellular Location Annotation ^@ ruffle membrane http://togogenome.org/gene/9483:CORIN ^@ http://purl.uniprot.org/uniprot/A0A2R8P1C2 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:APPL2 ^@ http://purl.uniprot.org/uniprot/U3BC20 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Endosome membrane|||Membrane|||Nucleus|||phagosome|||ruffle http://togogenome.org/gene/9483:PLA2G2A ^@ http://purl.uniprot.org/uniprot/U3BS74 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9483:SERPINF1 ^@ http://purl.uniprot.org/uniprot/F6WRV2 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9483:DPPA5 ^@ http://purl.uniprot.org/uniprot/F7G9E9 ^@ Similarity ^@ Belongs to the KHDC1 family. http://togogenome.org/gene/9483:MAP7D2 ^@ http://purl.uniprot.org/uniprot/F7HHJ6|||http://purl.uniprot.org/uniprot/U3BW88 ^@ Similarity ^@ Belongs to the MAP7 family. http://togogenome.org/gene/9483:CYP2C8 ^@ http://purl.uniprot.org/uniprot/A0P8Q9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9483:TAGLN2 ^@ http://purl.uniprot.org/uniprot/U3EHG7 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/9483:GPR68 ^@ http://purl.uniprot.org/uniprot/F7IGI0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9483:LOC100414113 ^@ http://purl.uniprot.org/uniprot/A0A8I3WN60 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9483:EFTUD2 ^@ http://purl.uniprot.org/uniprot/F7I888 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:PHF19 ^@ http://purl.uniprot.org/uniprot/F6ZWU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Polycomblike family.|||Nucleus http://togogenome.org/gene/9483:AGPAT4 ^@ http://purl.uniprot.org/uniprot/U3DG12 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9483:DLX2 ^@ http://purl.uniprot.org/uniprot/F6WHW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus http://togogenome.org/gene/9483:LOC103788996 ^@ http://purl.uniprot.org/uniprot/F7G1P7 ^@ Similarity ^@ Belongs to the cornifin (SPRR) family. http://togogenome.org/gene/9483:SCAMP4 ^@ http://purl.uniprot.org/uniprot/U3DGC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/9483:SUMO3 ^@ http://purl.uniprot.org/uniprot/U3EFP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin family. SUMO subfamily.|||Nucleus http://togogenome.org/gene/9483:NAPG ^@ http://purl.uniprot.org/uniprot/U3D967 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/9483:MFSD6 ^@ http://purl.uniprot.org/uniprot/F7IHY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. MFSD6 family.|||Membrane http://togogenome.org/gene/9483:PPAT ^@ http://purl.uniprot.org/uniprot/U3AS03 ^@ Cofactor|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/9483:PABIR2 ^@ http://purl.uniprot.org/uniprot/A0A8I3W0X8|||http://purl.uniprot.org/uniprot/A0A8J8Y7Y1 ^@ Similarity ^@ Belongs to the FAM122 family. http://togogenome.org/gene/9483:METTL4 ^@ http://purl.uniprot.org/uniprot/U3F057 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/9483:MAPRE3 ^@ http://purl.uniprot.org/uniprot/U3CWD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||cytoskeleton http://togogenome.org/gene/9483:FAM221A ^@ http://purl.uniprot.org/uniprot/U3AYF1 ^@ Similarity ^@ Belongs to the FAM221 family. http://togogenome.org/gene/9483:NUPR1 ^@ http://purl.uniprot.org/uniprot/U3FHX8 ^@ Similarity ^@ Belongs to the NUPR family. http://togogenome.org/gene/9483:LOC108590303 ^@ http://purl.uniprot.org/uniprot/F6S7T1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/9483:PPP3CB ^@ http://purl.uniprot.org/uniprot/A0A2R8MN08|||http://purl.uniprot.org/uniprot/F7GI92 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-2B subfamily. http://togogenome.org/gene/9483:GDF9 ^@ http://purl.uniprot.org/uniprot/F7FNW5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.|||Secreted http://togogenome.org/gene/9483:TARDBP ^@ http://purl.uniprot.org/uniprot/F7CL81 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:TLR8 ^@ http://purl.uniprot.org/uniprot/F6RY00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9483:GDI2 ^@ http://purl.uniprot.org/uniprot/U3C6M1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP. http://togogenome.org/gene/9483:LOC100388968 ^@ http://purl.uniprot.org/uniprot/F7HAR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:CYP26B1 ^@ http://purl.uniprot.org/uniprot/F7GVB0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9483:SLC43A2 ^@ http://purl.uniprot.org/uniprot/F7GZB3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:LHX1 ^@ http://purl.uniprot.org/uniprot/F6UGX4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:RNPEP ^@ http://purl.uniprot.org/uniprot/U3E9J7 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9483:AGXT ^@ http://purl.uniprot.org/uniprot/P31029 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.|||Catalyzes the transamination between L-serine and pyruvate and weakly contributes to gluconeogenesis from the L-serine metabolism.|||Catalyzes the transamination of glyoxylate to glycine and contributes to the glyoxylate detoxification.|||Homodimer.|||Mitochondrion matrix|||Peroxisome|||The intracellular compartmentalization of AGTX in mammalian hepatocytes is species dependent. In human and rabbit, AGTX is peroxisomal. In new world monkeys (marmoset) and rodents (rat and mouse), it is distributed approximately evenly between peroxisomes and mitochondria. In carnivores, like cat, the great majority of the enzyme is mitochondrial with only a small proportion being peroxisomal. http://togogenome.org/gene/9483:ZNF263 ^@ http://purl.uniprot.org/uniprot/F7EWU1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:HPGD ^@ http://purl.uniprot.org/uniprot/U3D0A5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9483:CRABP1 ^@ http://purl.uniprot.org/uniprot/F7HB22 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9483:AOX1 ^@ http://purl.uniprot.org/uniprot/M1ZMR7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/9483:LOC100411672 ^@ http://purl.uniprot.org/uniprot/A0A2R8MVQ0 ^@ Similarity ^@ In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.|||In the N-terminal section; belongs to the ubiquitin family. http://togogenome.org/gene/9483:ACVR2A ^@ http://purl.uniprot.org/uniprot/A0A5F4W6S4|||http://purl.uniprot.org/uniprot/F7AZW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9483:CHL1 ^@ http://purl.uniprot.org/uniprot/F6WU91|||http://purl.uniprot.org/uniprot/F6XG19|||http://purl.uniprot.org/uniprot/U3CMW1 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. http://togogenome.org/gene/9483:CFAP299 ^@ http://purl.uniprot.org/uniprot/F7HER8 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in spermatogenesis.|||Nucleus http://togogenome.org/gene/9483:ALDH4A1 ^@ http://purl.uniprot.org/uniprot/F6ZZR3 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9483:ANG ^@ http://purl.uniprot.org/uniprot/F7GKZ5 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9483:CD59 ^@ http://purl.uniprot.org/uniprot/F6SUS4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9483:TRHR ^@ http://purl.uniprot.org/uniprot/F7HI57 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. http://togogenome.org/gene/9483:RDH5 ^@ http://purl.uniprot.org/uniprot/F7IBF6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9483:PPM1K ^@ http://purl.uniprot.org/uniprot/A0A8I3XBQ6|||http://purl.uniprot.org/uniprot/F7HI43 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9483:GBP5 ^@ http://purl.uniprot.org/uniprot/F7E8X1|||http://purl.uniprot.org/uniprot/U3CSZ8 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9483:LTN1 ^@ http://purl.uniprot.org/uniprot/A0A2R8PEB5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LTN1 family.|||Component of the ribosome quality control complex (RQC).|||E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.|||cytosol http://togogenome.org/gene/9483:CA11 ^@ http://purl.uniprot.org/uniprot/U3ARJ9 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Does not have a catalytic activity. http://togogenome.org/gene/9483:SEC11C ^@ http://purl.uniprot.org/uniprot/U3BJG9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Component of the signal peptidase complex.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:KCND3 ^@ http://purl.uniprot.org/uniprot/U3C4J9|||http://purl.uniprot.org/uniprot/U3F539 ^@ Subcellular Location Annotation ^@ Membrane|||dendrite http://togogenome.org/gene/9483:SLC15A1 ^@ http://purl.uniprot.org/uniprot/F7IDU9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Interacts (via extracellular domain region) with trypsin.|||Membrane http://togogenome.org/gene/9483:DYNC1I2 ^@ http://purl.uniprot.org/uniprot/F6X617|||http://purl.uniprot.org/uniprot/F6XTS7|||http://purl.uniprot.org/uniprot/F6YXR6|||http://purl.uniprot.org/uniprot/U3E2W1|||http://purl.uniprot.org/uniprot/U3EU34 ^@ Similarity ^@ Belongs to the dynein intermediate chain family. http://togogenome.org/gene/9483:CMC4 ^@ http://purl.uniprot.org/uniprot/F6WXF4 ^@ Similarity ^@ Belongs to the CMC4 family. http://togogenome.org/gene/9483:NETO1 ^@ http://purl.uniprot.org/uniprot/F7IEJ7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:MVB12A ^@ http://purl.uniprot.org/uniprot/U3CK21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MVB12 family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9483:MOB3A ^@ http://purl.uniprot.org/uniprot/U3D0E7 ^@ Similarity ^@ Belongs to the MOB1/phocein family. http://togogenome.org/gene/9483:SULF2 ^@ http://purl.uniprot.org/uniprot/U3D2G4 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Binds 1 Ca(2+) ion per subunit.|||Cell surface|||Endoplasmic reticulum|||Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.|||Golgi stack|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9483:INPP4B ^@ http://purl.uniprot.org/uniprot/F7IRC6 ^@ Similarity ^@ Belongs to the inositol 3,4-bisphosphate 4-phosphatase family. http://togogenome.org/gene/9483:AP1S1 ^@ http://purl.uniprot.org/uniprot/U3E0K0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||Membrane|||clathrin-coated pit http://togogenome.org/gene/9483:RPL32 ^@ http://purl.uniprot.org/uniprot/A0A5F4WEM7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/9483:STK4 ^@ http://purl.uniprot.org/uniprot/U3C4N3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Nucleus http://togogenome.org/gene/9483:NXPH1 ^@ http://purl.uniprot.org/uniprot/U3ERP3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/9483:LOC100390657 ^@ http://purl.uniprot.org/uniprot/B0VX95 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:CD79A ^@ http://purl.uniprot.org/uniprot/F7AEC1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9483:CD68 ^@ http://purl.uniprot.org/uniprot/U3FBS0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9483:PTCH2 ^@ http://purl.uniprot.org/uniprot/U3E0M9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the patched family.|||Membrane http://togogenome.org/gene/9483:MEIG1 ^@ http://purl.uniprot.org/uniprot/A0A8I3VV56 ^@ Function|||Similarity ^@ Belongs to the MEIG1 family.|||Essential for spermiogenesis. http://togogenome.org/gene/9483:AGO4 ^@ http://purl.uniprot.org/uniprot/U3DZG7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argonaute family. Ago subfamily.|||Interacts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B. Interacts with ZFP36.|||P-body|||Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. http://togogenome.org/gene/9483:ALDOC ^@ http://purl.uniprot.org/uniprot/F7I8Q1 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/9483:VLDLR ^@ http://purl.uniprot.org/uniprot/F7HHP9|||http://purl.uniprot.org/uniprot/U3C8C5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:CHPF ^@ http://purl.uniprot.org/uniprot/B0KWJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9483:POP5 ^@ http://purl.uniprot.org/uniprot/F7ITC9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family.|||Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.|||nucleolus http://togogenome.org/gene/9483:ETNPPL ^@ http://purl.uniprot.org/uniprot/A0A5F4W855 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9483:COPS7A ^@ http://purl.uniprot.org/uniprot/U3DCD7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:IL1F10 ^@ http://purl.uniprot.org/uniprot/F7CCC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9483:DIMT1 ^@ http://purl.uniprot.org/uniprot/U3FN76 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. http://togogenome.org/gene/9483:GPR101 ^@ http://purl.uniprot.org/uniprot/F7I257 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9483:SPSB2 ^@ http://purl.uniprot.org/uniprot/F7AY68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPSB family.|||Belongs to the TRIM/RBCC family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:SLC12A3 ^@ http://purl.uniprot.org/uniprot/F7IPQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9483:IER5 ^@ http://purl.uniprot.org/uniprot/F7G7P3 ^@ Similarity ^@ Belongs to the IER family. http://togogenome.org/gene/9483:FAM199X ^@ http://purl.uniprot.org/uniprot/F7GPT7 ^@ Similarity ^@ Belongs to the FAM199 family. http://togogenome.org/gene/9483:CCL21 ^@ http://purl.uniprot.org/uniprot/F7B701 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9483:DEFB123 ^@ http://purl.uniprot.org/uniprot/A0A8I3W278 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9483:S100A10 ^@ http://purl.uniprot.org/uniprot/F7FGI3 ^@ Function ^@ Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. http://togogenome.org/gene/9483:TSPYL4 ^@ http://purl.uniprot.org/uniprot/U3FHE0 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9483:GADL1 ^@ http://purl.uniprot.org/uniprot/U3DGB7 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9483:ERCC3 ^@ http://purl.uniprot.org/uniprot/U3CZS4 ^@ Similarity ^@ Belongs to the helicase family. RAD25/XPB subfamily. http://togogenome.org/gene/9483:LOC100387518 ^@ http://purl.uniprot.org/uniprot/A0A2R8P242 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/9483:XPR1 ^@ http://purl.uniprot.org/uniprot/U3C4S1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SYG1 (TC 2.A.94) family.|||Membrane http://togogenome.org/gene/9483:LOC100390661 ^@ http://purl.uniprot.org/uniprot/A0A5F4WD95 ^@ Similarity|||Subunit ^@ Belongs to the Ntn-hydrolase family.|||Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer. http://togogenome.org/gene/9483:ARHGEF6 ^@ http://purl.uniprot.org/uniprot/U3DIW2 ^@ Subcellular Location Annotation ^@ lamellipodium http://togogenome.org/gene/9483:MFN1 ^@ http://purl.uniprot.org/uniprot/U3FX89 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9483:SLC16A3 ^@ http://purl.uniprot.org/uniprot/F6U4G6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/9483:PMP22 ^@ http://purl.uniprot.org/uniprot/F7HND7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Might be involved in growth regulation, and in myelinization in the peripheral nervous system. http://togogenome.org/gene/9483:ASB9 ^@ http://purl.uniprot.org/uniprot/F6S5G6 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9483:MRPL12 ^@ http://purl.uniprot.org/uniprot/F7HX78 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL12 family. http://togogenome.org/gene/9483:TRAK2 ^@ http://purl.uniprot.org/uniprot/U3FJ47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the milton family.|||Early endosome|||Mitochondrion http://togogenome.org/gene/9483:AQP7 ^@ http://purl.uniprot.org/uniprot/U3CSN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9483:FLOT2 ^@ http://purl.uniprot.org/uniprot/U3CGZ2|||http://purl.uniprot.org/uniprot/U3FTR0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily.|||Cell membrane|||Endosome|||Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.|||May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.|||Membrane|||Membrane raft|||caveola http://togogenome.org/gene/9483:OTULINL ^@ http://purl.uniprot.org/uniprot/A0A8I3W553 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C65 family. Otulin subfamily.|||Cytoplasm http://togogenome.org/gene/9483:SF3B1 ^@ http://purl.uniprot.org/uniprot/F6R058 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3B1 family.|||Nucleus http://togogenome.org/gene/9483:G6PC3 ^@ http://purl.uniprot.org/uniprot/F6PJG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9483:CANT1 ^@ http://purl.uniprot.org/uniprot/F7D6T0 ^@ Similarity ^@ Belongs to the apyrase family. http://togogenome.org/gene/9483:LOC100413069 ^@ http://purl.uniprot.org/uniprot/A0A8I3WQR7 ^@ Similarity ^@ Belongs to the SPAN-X family. http://togogenome.org/gene/9483:NT5C3A ^@ http://purl.uniprot.org/uniprot/F7B495|||http://purl.uniprot.org/uniprot/F7GS71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrimidine 5'-nucleotidase family.|||Cytoplasm http://togogenome.org/gene/9483:B3GAT1 ^@ http://purl.uniprot.org/uniprot/A0A5K1UD53|||http://purl.uniprot.org/uniprot/U3DLU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:HTR2B ^@ http://purl.uniprot.org/uniprot/F6U6Y0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||synaptosome http://togogenome.org/gene/9483:LIPT1 ^@ http://purl.uniprot.org/uniprot/F6UBC6 ^@ Similarity ^@ Belongs to the LplA family. http://togogenome.org/gene/9483:LRP5 ^@ http://purl.uniprot.org/uniprot/U3D8R2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LDLR family.|||Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes.|||Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:FGFBP2 ^@ http://purl.uniprot.org/uniprot/A0A8I3VWG8 ^@ Similarity ^@ Belongs to the fibroblast growth factor-binding protein family. http://togogenome.org/gene/9483:SCN1B ^@ http://purl.uniprot.org/uniprot/F6Y804 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:SYNJ1 ^@ http://purl.uniprot.org/uniprot/F6XBI3|||http://purl.uniprot.org/uniprot/F7GAV4 ^@ Similarity ^@ Belongs to the synaptojanin family.|||In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family. http://togogenome.org/gene/9483:PLA2G4A ^@ http://purl.uniprot.org/uniprot/A0A8J8Y9K6 ^@ Domain ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding. http://togogenome.org/gene/9483:ABCE1 ^@ http://purl.uniprot.org/uniprot/U3FUZ0 ^@ Subunit ^@ Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and NHERF1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through NHERF1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation. http://togogenome.org/gene/9483:PRDX1 ^@ http://purl.uniprot.org/uniprot/F7IHK8 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/9483:ALDOA ^@ http://purl.uniprot.org/uniprot/F6ZQC9 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/9483:ELOC ^@ http://purl.uniprot.org/uniprot/U3DRH8 ^@ Similarity ^@ Belongs to the SKP1 family. http://togogenome.org/gene/9483:RAB14 ^@ http://purl.uniprot.org/uniprot/F7BFK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Recycling endosome|||phagosome|||trans-Golgi network membrane http://togogenome.org/gene/9483:LOC103787267 ^@ http://purl.uniprot.org/uniprot/B0KWA5 ^@ Similarity ^@ Belongs to the KHDC1 family. http://togogenome.org/gene/9483:LOC100394089 ^@ http://purl.uniprot.org/uniprot/F7BE03 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/9483:S1PR1 ^@ http://purl.uniprot.org/uniprot/F7HBI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:UBN1 ^@ http://purl.uniprot.org/uniprot/A0A5F4WG95|||http://purl.uniprot.org/uniprot/F7CG91|||http://purl.uniprot.org/uniprot/F7CGB1|||http://purl.uniprot.org/uniprot/U3DNI9 ^@ Similarity ^@ Belongs to the ubinuclein family. http://togogenome.org/gene/9483:LOC100395473 ^@ http://purl.uniprot.org/uniprot/H9KWM8 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9483:RNH1 ^@ http://purl.uniprot.org/uniprot/F7HNE6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.|||Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis. http://togogenome.org/gene/9483:TFIP11 ^@ http://purl.uniprot.org/uniprot/F6YQH7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFP11/STIP family.|||Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.|||Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.|||Nucleus http://togogenome.org/gene/9483:TLR3 ^@ http://purl.uniprot.org/uniprot/F7I1W0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9483:FAM32A ^@ http://purl.uniprot.org/uniprot/U3D055 ^@ Similarity ^@ Belongs to the FAM32 family. http://togogenome.org/gene/9483:LAMC1 ^@ http://purl.uniprot.org/uniprot/U3CXM9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||basement membrane http://togogenome.org/gene/9483:SUDS3 ^@ http://purl.uniprot.org/uniprot/A0A8I4A0J6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:KCNS2 ^@ http://purl.uniprot.org/uniprot/A0A2R8MYD8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9483:BCCIP ^@ http://purl.uniprot.org/uniprot/F7I620 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCP1 family.|||May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).|||Nucleus|||spindle pole http://togogenome.org/gene/9483:TTR ^@ http://purl.uniprot.org/uniprot/H1AAP6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transthyretin family.|||Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4.|||Secreted|||Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. http://togogenome.org/gene/9483:MOV10 ^@ http://purl.uniprot.org/uniprot/F6UZ66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.|||P-body http://togogenome.org/gene/9483:VRK1 ^@ http://purl.uniprot.org/uniprot/A0A5F4W549|||http://purl.uniprot.org/uniprot/U3E880 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:LOC100404525 ^@ http://purl.uniprot.org/uniprot/F7FTX6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS1 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.|||Cytoplasm|||May play a role during erythropoiesis through regulation of transcription factor DDIT3.|||Nucleus|||nucleolus http://togogenome.org/gene/9483:TBX15 ^@ http://purl.uniprot.org/uniprot/A0A2R8PB87|||http://purl.uniprot.org/uniprot/F7HZ49 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9483:DNAJB12 ^@ http://purl.uniprot.org/uniprot/F7CSU9|||http://purl.uniprot.org/uniprot/U3DLP5 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:POLR3K ^@ http://purl.uniprot.org/uniprot/B0VX71 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/9483:TMEM182 ^@ http://purl.uniprot.org/uniprot/A0A2R8P5M8|||http://purl.uniprot.org/uniprot/A0A5F4WM85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM182 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:NDUFA3 ^@ http://purl.uniprot.org/uniprot/F6XMD2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA3 subunit family.|||Complex I is composed of 45 different subunits.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9483:ABCB9 ^@ http://purl.uniprot.org/uniprot/U3E6C0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.|||Membrane|||Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and NHERF1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through NHERF1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation. http://togogenome.org/gene/9483:ERMN ^@ http://purl.uniprot.org/uniprot/A0A8I3WEY0 ^@ Function|||Subunit ^@ Binds actin.|||Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS. http://togogenome.org/gene/9483:SEC62 ^@ http://purl.uniprot.org/uniprot/F7C318 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC62 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:NFIB ^@ http://purl.uniprot.org/uniprot/A0A2R8MJS4|||http://purl.uniprot.org/uniprot/F6XMK2|||http://purl.uniprot.org/uniprot/F6YSB0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTF/NF-I family.|||Binds DNA as a homodimer.|||Nucleus|||Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. http://togogenome.org/gene/9483:GET1 ^@ http://purl.uniprot.org/uniprot/B0KW89|||http://purl.uniprot.org/uniprot/F7ISC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WRB/GET1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:KCNN3 ^@ http://purl.uniprot.org/uniprot/F7I0V2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:MTRF1 ^@ http://purl.uniprot.org/uniprot/F7GQR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Mitochondrion http://togogenome.org/gene/9483:DGKE ^@ http://purl.uniprot.org/uniprot/U3DBL3 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/9483:TAS1R2 ^@ http://purl.uniprot.org/uniprot/F6VWQ2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9483:UTP15 ^@ http://purl.uniprot.org/uniprot/U3ANT8 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9483:PSMA4 ^@ http://purl.uniprot.org/uniprot/U3EX30 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9483:KATNA1 ^@ http://purl.uniprot.org/uniprot/F7HIN0|||http://purl.uniprot.org/uniprot/U3FQJ4 ^@ Activity Regulation|||Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.|||Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.|||Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.|||Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Midbody|||Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.|||The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.|||Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.|||centrosome|||spindle|||spindle pole http://togogenome.org/gene/9483:GTF2F1 ^@ http://purl.uniprot.org/uniprot/U3CYN1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIF alpha subunit family.|||Nucleus|||TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. http://togogenome.org/gene/9483:LPL ^@ http://purl.uniprot.org/uniprot/F7HXL1 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Cell membrane|||Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.|||Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted|||Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.|||extracellular matrix http://togogenome.org/gene/9483:DYRK3 ^@ http://purl.uniprot.org/uniprot/F7IFK0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. http://togogenome.org/gene/9483:C11H11orf58 ^@ http://purl.uniprot.org/uniprot/F7HVS5 ^@ Similarity ^@ Belongs to the SMAP family. http://togogenome.org/gene/9483:MAGOH ^@ http://purl.uniprot.org/uniprot/F7ID78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mago nashi family.|||Nucleus http://togogenome.org/gene/9483:POLH ^@ http://purl.uniprot.org/uniprot/F7HZ00 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:PDK1 ^@ http://purl.uniprot.org/uniprot/U3FE81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9483:ZSCAN25 ^@ http://purl.uniprot.org/uniprot/F7IRV2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:USP48 ^@ http://purl.uniprot.org/uniprot/U3BS81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Nucleus http://togogenome.org/gene/9483:CTNS ^@ http://purl.uniprot.org/uniprot/U3FGV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cystinosin family.|||Membrane http://togogenome.org/gene/9483:NSUN4 ^@ http://purl.uniprot.org/uniprot/F7HD16 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/9483:HYCC2 ^@ http://purl.uniprot.org/uniprot/A0A2R8MZ64|||http://purl.uniprot.org/uniprot/A0A8I4A4C2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Hyccin family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/9483:PRKX ^@ http://purl.uniprot.org/uniprot/U3BK70 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:LOC103793463 ^@ http://purl.uniprot.org/uniprot/A0A2R8MGA0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA5 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:TBX5 ^@ http://purl.uniprot.org/uniprot/F7I9S7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9483:SLC41A1 ^@ http://purl.uniprot.org/uniprot/F7FY35 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/9483:LOC100399888 ^@ http://purl.uniprot.org/uniprot/F7GHA7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:SRP9 ^@ http://purl.uniprot.org/uniprot/F7IIG1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP9 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.|||Cytoplasm http://togogenome.org/gene/9483:CNTNAP4 ^@ http://purl.uniprot.org/uniprot/U3FWU7 ^@ Caution|||Similarity ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:SIAH2 ^@ http://purl.uniprot.org/uniprot/F7I4Z0 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/9483:TMEM208 ^@ http://purl.uniprot.org/uniprot/U3C559 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM208 family.|||Endoplasmic reticulum membrane|||May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.|||Membrane http://togogenome.org/gene/9483:ARL1 ^@ http://purl.uniprot.org/uniprot/F6VEE2 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9483:SLC26A7 ^@ http://purl.uniprot.org/uniprot/F7G2J9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/9483:ISY1 ^@ http://purl.uniprot.org/uniprot/U3D161 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ISY1 family.|||Nucleus http://togogenome.org/gene/9483:THOC6 ^@ http://purl.uniprot.org/uniprot/U3C1X1 ^@ Similarity ^@ Belongs to the WD repeat THOC6 family. http://togogenome.org/gene/9483:GCDH ^@ http://purl.uniprot.org/uniprot/F7IF96 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9483:ACTL6B ^@ http://purl.uniprot.org/uniprot/F7FRF7 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9483:MRRF ^@ http://purl.uniprot.org/uniprot/A0A2R8M7C8 ^@ Function|||Similarity ^@ Belongs to the RRF family.|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/9483:LOC100393733 ^@ http://purl.uniprot.org/uniprot/A0A5F4VY33 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/9483:ZUP1 ^@ http://purl.uniprot.org/uniprot/U3DBX6|||http://purl.uniprot.org/uniprot/U3EEL3 ^@ Similarity|||Subunit ^@ Belongs to the peptidase C78 family. ZUFSP subfamily.|||Interacts with RPA1 and RPA2. http://togogenome.org/gene/9483:FAM187B ^@ http://purl.uniprot.org/uniprot/F6SRZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM187 family.|||Membrane http://togogenome.org/gene/9483:HSBP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8PF30 ^@ Similarity ^@ Belongs to the HSBP1 family. http://togogenome.org/gene/9483:GPR182 ^@ http://purl.uniprot.org/uniprot/F6QCH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:PRKCB ^@ http://purl.uniprot.org/uniprot/U3EAU9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.|||Cytoplasm|||Membrane|||Nucleus http://togogenome.org/gene/9483:ACOT13 ^@ http://purl.uniprot.org/uniprot/F7IQA2 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/9483:DUSP29 ^@ http://purl.uniprot.org/uniprot/F7IJ24|||http://purl.uniprot.org/uniprot/U3DS87 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/9483:ADPRH ^@ http://purl.uniprot.org/uniprot/F6YNG9 ^@ Similarity ^@ Belongs to the ADP-ribosylglycohydrolase family. http://togogenome.org/gene/9483:BEST3 ^@ http://purl.uniprot.org/uniprot/U3DSN5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms calcium-sensitive chloride channels. Permeable to bicarbonate.|||Membrane http://togogenome.org/gene/9483:TMEM192 ^@ http://purl.uniprot.org/uniprot/A0A2R8MKT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM192 family.|||Late endosome|||Lysosome membrane|||Membrane http://togogenome.org/gene/9483:PRPF38A ^@ http://purl.uniprot.org/uniprot/U3FEZ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PRP38 family.|||Component of the spliceosome B complex.|||Involved in pre-mRNA splicing as a component of the spliceosome.|||Nucleus http://togogenome.org/gene/9483:TAF6 ^@ http://purl.uniprot.org/uniprot/F7BUA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF6 family.|||Nucleus http://togogenome.org/gene/9483:TRIM55 ^@ http://purl.uniprot.org/uniprot/U3DH77|||http://purl.uniprot.org/uniprot/U3E739 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:KCNJ3 ^@ http://purl.uniprot.org/uniprot/F7AN67 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.|||Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.|||Membrane|||This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat. http://togogenome.org/gene/9483:HTRA3 ^@ http://purl.uniprot.org/uniprot/A0A8I3WX49|||http://purl.uniprot.org/uniprot/F7CCB8 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/9483:SERPINE2 ^@ http://purl.uniprot.org/uniprot/F7I8D6 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9483:ACAD10 ^@ http://purl.uniprot.org/uniprot/F6SQR9 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9483:PGD ^@ http://purl.uniprot.org/uniprot/U3CWW4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the 6-phosphogluconate dehydrogenase family.|||Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.|||Homodimer. http://togogenome.org/gene/9483:GNPDA2 ^@ http://purl.uniprot.org/uniprot/A0A5F4W7E7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/9483:CMTM8 ^@ http://purl.uniprot.org/uniprot/U3F7P3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:ADAM22 ^@ http://purl.uniprot.org/uniprot/A0A2R8MSI5|||http://purl.uniprot.org/uniprot/A0A8I3W746|||http://purl.uniprot.org/uniprot/A0A8J8XKU3|||http://purl.uniprot.org/uniprot/F7IT50|||http://purl.uniprot.org/uniprot/U3DZK3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:UIMC1 ^@ http://purl.uniprot.org/uniprot/U3CM25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAP80 family.|||Nucleus http://togogenome.org/gene/9483:PCK2 ^@ http://purl.uniprot.org/uniprot/F7CT55 ^@ Similarity|||Subunit ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.|||Monomer. http://togogenome.org/gene/9483:HTRA1 ^@ http://purl.uniprot.org/uniprot/U3F3W6 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/9483:UNC13D ^@ http://purl.uniprot.org/uniprot/A0A8I4A115 ^@ Similarity ^@ Belongs to the unc-13 family. http://togogenome.org/gene/9483:SLCO1C1 ^@ http://purl.uniprot.org/uniprot/A0A8I3XAJ3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:LAP3 ^@ http://purl.uniprot.org/uniprot/F7IIB5 ^@ Similarity|||Subunit ^@ Belongs to the peptidase M17 family.|||Homohexamer. http://togogenome.org/gene/9483:CYP1A2 ^@ http://purl.uniprot.org/uniprot/O77810 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid. Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer. Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA. May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent). Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin. Metabolizes caffeine via N3-demethylation.|||Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane|||Interacts with PGRMC1; the interaction requires PGRMC1 homodimerization.|||Microsome membrane http://togogenome.org/gene/9483:SNAP25 ^@ http://purl.uniprot.org/uniprot/U3DAS2|||http://purl.uniprot.org/uniprot/U3DKT2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNAP-25 family.|||Cell membrane|||Membrane|||Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.|||Photoreceptor inner segment|||synaptosome|||t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. http://togogenome.org/gene/9483:CYB5RL ^@ http://purl.uniprot.org/uniprot/U3BEP3 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/9483:PALMD ^@ http://purl.uniprot.org/uniprot/U3EDL0 ^@ Similarity ^@ Belongs to the paralemmin family. http://togogenome.org/gene/9483:MCM7 ^@ http://purl.uniprot.org/uniprot/F7ALH8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Nucleus http://togogenome.org/gene/9483:ARG2 ^@ http://purl.uniprot.org/uniprot/F7A825 ^@ Cofactor|||Similarity ^@ Belongs to the arginase family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9483:LOC100393645 ^@ http://purl.uniprot.org/uniprot/F7IEU2 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DIPP subfamily. http://togogenome.org/gene/9483:GNG4 ^@ http://purl.uniprot.org/uniprot/F6QSV4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9483:PPP4R2 ^@ http://purl.uniprot.org/uniprot/U3D0Z9 ^@ Similarity ^@ Belongs to the PPP4R2 family. http://togogenome.org/gene/9483:POPDC3 ^@ http://purl.uniprot.org/uniprot/F7GHY4 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/9483:ADPRHL1 ^@ http://purl.uniprot.org/uniprot/F6PXM0 ^@ Similarity ^@ Belongs to the ADP-ribosylglycohydrolase family. http://togogenome.org/gene/9483:FMR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8MBF6|||http://purl.uniprot.org/uniprot/U3CRA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMR1 family.|||Cell membrane|||Cytoplasmic ribonucleoprotein granule|||Membrane|||Perikaryon|||Presynaptic cell membrane|||Stress granule|||Synaptic cell membrane|||axon|||centromere|||dendrite|||dendritic spine|||filopodium tip|||growth cone|||neuron projection|||nucleolus|||perinuclear region|||synaptosome http://togogenome.org/gene/9483:KYNU ^@ http://purl.uniprot.org/uniprot/F6YX40 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kynureninase family.|||Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:PSMD8 ^@ http://purl.uniprot.org/uniprot/U3DPY5 ^@ Similarity ^@ Belongs to the proteasome subunit S14 family. http://togogenome.org/gene/9483:LOC108588476 ^@ http://purl.uniprot.org/uniprot/A0A8I3W3L4 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9483:TMSB15A ^@ http://purl.uniprot.org/uniprot/F7ILT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/9483:ZNF446 ^@ http://purl.uniprot.org/uniprot/A0A5F4VTG5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:CXCL14 ^@ http://purl.uniprot.org/uniprot/A0A8I3WNC3 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9483:CEP170 ^@ http://purl.uniprot.org/uniprot/U3BXG4|||http://purl.uniprot.org/uniprot/U3CHE7|||http://purl.uniprot.org/uniprot/U3E724 ^@ Similarity ^@ Belongs to the CEP170 family. http://togogenome.org/gene/9483:ATG5 ^@ http://purl.uniprot.org/uniprot/A0A2R8M348|||http://purl.uniprot.org/uniprot/A0A2R8ML30|||http://purl.uniprot.org/uniprot/A0A8I3WPZ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG5 family.|||Conjugated with ATG12.|||Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.|||May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.|||Preautophagosomal structure membrane http://togogenome.org/gene/9483:FAM135A ^@ http://purl.uniprot.org/uniprot/A0A2R8MX13|||http://purl.uniprot.org/uniprot/A0A8I3W5F0|||http://purl.uniprot.org/uniprot/F7DGS6|||http://purl.uniprot.org/uniprot/U3C872 ^@ Similarity ^@ Belongs to the FAM135 family. http://togogenome.org/gene/9483:PGAP2 ^@ http://purl.uniprot.org/uniprot/U3EUI3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PGAP2 family.|||Interacts with PGAP2IP.|||Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface.|||Membrane http://togogenome.org/gene/9483:NPAS3 ^@ http://purl.uniprot.org/uniprot/A0A2R8M666 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:DCP1A ^@ http://purl.uniprot.org/uniprot/U3D2Q4 ^@ Similarity ^@ Belongs to the DCP1 family. http://togogenome.org/gene/9483:RNF121 ^@ http://purl.uniprot.org/uniprot/F6WTX2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:MYT1L ^@ http://purl.uniprot.org/uniprot/A0A5F4VSN3|||http://purl.uniprot.org/uniprot/F7CCJ7|||http://purl.uniprot.org/uniprot/F7CCX3|||http://purl.uniprot.org/uniprot/U3F544 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYT1 family.|||Nucleus http://togogenome.org/gene/9483:B3GALT5 ^@ http://purl.uniprot.org/uniprot/F6YSH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:CYP2C18 ^@ http://purl.uniprot.org/uniprot/A0A171P0Y7 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9483:TPPP2 ^@ http://purl.uniprot.org/uniprot/F7IA21 ^@ Similarity ^@ Belongs to the TPPP family. http://togogenome.org/gene/9483:TJP2 ^@ http://purl.uniprot.org/uniprot/U3CA71|||http://purl.uniprot.org/uniprot/U3CSI5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9483:FLNB ^@ http://purl.uniprot.org/uniprot/A0A8J8XD29|||http://purl.uniprot.org/uniprot/A0A8J8Y4Q1|||http://purl.uniprot.org/uniprot/U3DG44 ^@ Similarity ^@ Belongs to the filamin family. http://togogenome.org/gene/9483:MRPL43 ^@ http://purl.uniprot.org/uniprot/U3E5Q6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL43 family.|||Mitochondrion http://togogenome.org/gene/9483:YME1L1 ^@ http://purl.uniprot.org/uniprot/U3BKR7 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/9483:TAMM41 ^@ http://purl.uniprot.org/uniprot/A0A2R8MH54|||http://purl.uniprot.org/uniprot/F7BR22 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TAM41 family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:SERPING1 ^@ http://purl.uniprot.org/uniprot/F7B8K7 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9483:FAN1 ^@ http://purl.uniprot.org/uniprot/U3DBA7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAN1 family.|||Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.|||Nucleus http://togogenome.org/gene/9483:PTAFR ^@ http://purl.uniprot.org/uniprot/F7IRI3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with ARRB1.|||Membrane|||Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9483:SARS1 ^@ http://purl.uniprot.org/uniprot/A0A2R8NFA7 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily. http://togogenome.org/gene/9483:FIGNL1 ^@ http://purl.uniprot.org/uniprot/F7H702 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9483:WASF2 ^@ http://purl.uniprot.org/uniprot/F7BLL1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCAR/WAVE family.|||Binds actin and the Arp2/3 complex.|||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|||cytoskeleton http://togogenome.org/gene/9483:SIN3A ^@ http://purl.uniprot.org/uniprot/F7A408 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:BRMS1 ^@ http://purl.uniprot.org/uniprot/F7ISX8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:LHFPL4 ^@ http://purl.uniprot.org/uniprot/F7IP59 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:ANKRD13D ^@ http://purl.uniprot.org/uniprot/U3CBJ2 ^@ Function|||Subcellular Location Annotation ^@ Endosome|||Late endosome|||Membrane|||Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. http://togogenome.org/gene/9483:NXPH2 ^@ http://purl.uniprot.org/uniprot/A0A8I3WVL7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/9483:NR1H4 ^@ http://purl.uniprot.org/uniprot/A0A2R8MU47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9483:EIF4EBP3 ^@ http://purl.uniprot.org/uniprot/F7CJA3 ^@ Similarity ^@ Belongs to the eIF4E-binding protein family. http://togogenome.org/gene/9483:NUBP1 ^@ http://purl.uniprot.org/uniprot/F7HS53 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.|||Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.|||Cell projection|||Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.|||Cytoplasm|||Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1. http://togogenome.org/gene/9483:LIPA ^@ http://purl.uniprot.org/uniprot/F6QJ20 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9483:S1PR2 ^@ http://purl.uniprot.org/uniprot/F7H567 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:LOC100415308 ^@ http://purl.uniprot.org/uniprot/J9QRH9 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/9483:SPOUT1 ^@ http://purl.uniprot.org/uniprot/B0KWE0 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. http://togogenome.org/gene/9483:SERPINH1 ^@ http://purl.uniprot.org/uniprot/F6WJ59 ^@ Function|||Similarity ^@ Belongs to the serpin family.|||Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. http://togogenome.org/gene/9483:TSPAN13 ^@ http://purl.uniprot.org/uniprot/F7HX26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9483:CPS1 ^@ http://purl.uniprot.org/uniprot/F7G8E2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:PAIP2B ^@ http://purl.uniprot.org/uniprot/U3FGY1 ^@ Similarity ^@ Belongs to the PAIP2 family. http://togogenome.org/gene/9483:ATP1A1 ^@ http://purl.uniprot.org/uniprot/A0A8I4A1I3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:URAD ^@ http://purl.uniprot.org/uniprot/F7GNJ9 ^@ Function|||Similarity ^@ Belongs to the OHCU decarboxylase family.|||Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin. http://togogenome.org/gene/9483:MYH10 ^@ http://purl.uniprot.org/uniprot/F7I9C3|||http://purl.uniprot.org/uniprot/U3D4N5|||http://purl.uniprot.org/uniprot/U3EDP2 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9483:RNASE4 ^@ http://purl.uniprot.org/uniprot/A0A2R8MAQ1 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9483:OR13J1 ^@ http://purl.uniprot.org/uniprot/A0A5F4WC48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:TMEM258 ^@ http://purl.uniprot.org/uniprot/F7GXA9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST5 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/9483:RNF152 ^@ http://purl.uniprot.org/uniprot/F7HAL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNF152 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9483:SIM1 ^@ http://purl.uniprot.org/uniprot/F7HZQ9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:CLDN3 ^@ http://purl.uniprot.org/uniprot/F7BNR9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the claudin family.|||Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9483:WSCD1 ^@ http://purl.uniprot.org/uniprot/F7I403 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WSCD family.|||Golgi apparatus membrane|||Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans. http://togogenome.org/gene/9483:TMCC3 ^@ http://purl.uniprot.org/uniprot/F7ICJ2 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/9483:CALR ^@ http://purl.uniprot.org/uniprot/F7I5Y4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calreticulin family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9483:GATA2 ^@ http://purl.uniprot.org/uniprot/F7HXJ7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:LIPM ^@ http://purl.uniprot.org/uniprot/A0A8I3WDX7 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9483:LOC100398424 ^@ http://purl.uniprot.org/uniprot/A0A8I3WLK8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9483:TRAPPC6B ^@ http://purl.uniprot.org/uniprot/U3AR63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||cis-Golgi network http://togogenome.org/gene/9483:FOLR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8MPG7 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/9483:FN3K ^@ http://purl.uniprot.org/uniprot/F6U657 ^@ Similarity ^@ Belongs to the fructosamine kinase family. http://togogenome.org/gene/9483:LOC100406262 ^@ http://purl.uniprot.org/uniprot/B0VX86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:TAC3 ^@ http://purl.uniprot.org/uniprot/F6QN68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tachykinin family.|||Secreted http://togogenome.org/gene/9483:NDRG1 ^@ http://purl.uniprot.org/uniprot/U3C0J9 ^@ Similarity ^@ Belongs to the NDRG family. http://togogenome.org/gene/9483:NUP50 ^@ http://purl.uniprot.org/uniprot/F7IC26 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/9483:RRM2 ^@ http://purl.uniprot.org/uniprot/F7GFM3 ^@ Similarity ^@ Belongs to the ribonucleoside diphosphate reductase small chain family. http://togogenome.org/gene/9483:GCAT ^@ http://purl.uniprot.org/uniprot/U3ECL4 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9483:B9D2 ^@ http://purl.uniprot.org/uniprot/F7BH58 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/9483:OR51B6 ^@ http://purl.uniprot.org/uniprot/A0A5F4VVN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:EDEM2 ^@ http://purl.uniprot.org/uniprot/F6TUE0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9483:UBR1 ^@ http://purl.uniprot.org/uniprot/U3EWC6 ^@ Function|||Similarity ^@ Belongs to the UBR1 family.|||Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. http://togogenome.org/gene/9483:NAA11 ^@ http://purl.uniprot.org/uniprot/F7DDU0 ^@ Similarity ^@ Belongs to the acetyltransferase family. ARD1 subfamily. http://togogenome.org/gene/9483:ALOX12 ^@ http://purl.uniprot.org/uniprot/U3B0U1 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the lipoxygenase family.|||Binds 1 Fe cation per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:PFDN2 ^@ http://purl.uniprot.org/uniprot/F7F6X9 ^@ Function|||Similarity ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. http://togogenome.org/gene/9483:LOC100409982 ^@ http://purl.uniprot.org/uniprot/U3CM30 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9483:PAPOLG ^@ http://purl.uniprot.org/uniprot/U3FHB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the poly(A) polymerase family.|||Nucleus http://togogenome.org/gene/9483:LOC100409364 ^@ http://purl.uniprot.org/uniprot/F7IF34 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the Flattop family. http://togogenome.org/gene/9483:NEURL2 ^@ http://purl.uniprot.org/uniprot/F7I9Z1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:GHR ^@ http://purl.uniprot.org/uniprot/A0A5F4WE18|||http://purl.uniprot.org/uniprot/A0A8I3WN21 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||Cell membrane|||The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. http://togogenome.org/gene/9483:OS9 ^@ http://purl.uniprot.org/uniprot/U3CKK0|||http://purl.uniprot.org/uniprot/U3D7F6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OS-9 family.|||Endoplasmic reticulum lumen|||Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation. http://togogenome.org/gene/9483:FAM83G ^@ http://purl.uniprot.org/uniprot/U3BLH7 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9483:IL17F ^@ http://purl.uniprot.org/uniprot/A6N6I9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-17 family.|||Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. IL17A-IL17F signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. IL17A-IL17F is primarily involved in host defense against extracellular bacteria and fungi by inducing neutrophilic inflammation. As signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers. IL17F homodimer can signal via IL17RC homodimeric receptor complex, triggering downstream activation of TRAF6 and NF-kappa-B signaling pathway. Via IL17RC induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi. Likely via IL17RC, promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression. Regulates the composition of intestinal microbiota and immune tolerance by inducing antimicrobial proteins that specifically control the growth of commensal Firmicutes and Bacteroidetes.|||Homodimer; disulfide-linked (By similarity). Heterodimer with IL17A (IL17A-IL17F) (By similarity). Forms complexes with IL17RA and IL17RC receptors with 2:1 binding stoichiometry: two receptor chains for one interleukin molecule. IL17F homodimer forms predominantly complexes with IL17RC homodimer, whereas IL17A-IL17F favors complexes with IL17RA-IL17RC. IL17RA and IL17RC chains cannot distinguish between IL17A and IL17F molecules, potentially enabling the formation of topologically distinct complexes (By similarity).|||Secreted http://togogenome.org/gene/9483:LDHAL6B ^@ http://purl.uniprot.org/uniprot/A0A5F4W344 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/9483:SPRYD4 ^@ http://purl.uniprot.org/uniprot/F7D4Z8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Nucleus http://togogenome.org/gene/9483:NECAP2 ^@ http://purl.uniprot.org/uniprot/F7DFK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NECAP family.|||Involved in endocytosis.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9483:MOB1A ^@ http://purl.uniprot.org/uniprot/F7H5V9 ^@ Similarity ^@ Belongs to the MOB1/phocein family. http://togogenome.org/gene/9483:DKK1 ^@ http://purl.uniprot.org/uniprot/F7IQ87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/9483:BEX5 ^@ http://purl.uniprot.org/uniprot/F6V5P7 ^@ Similarity ^@ Belongs to the BEX family. http://togogenome.org/gene/9483:CFAP69 ^@ http://purl.uniprot.org/uniprot/B0VXE6 ^@ Function|||Subcellular Location Annotation ^@ Cilium- and flagellum-associated protein (By similarity). In the olfactory epithelium, regulates the speed of activation and termination of the odor response and thus contributes to the robustness of olfactory transduction pathways (By similarity). Required for sperm flagellum assembly and stability (By similarity).|||cilium|||flagellum http://togogenome.org/gene/9483:TP53I11 ^@ http://purl.uniprot.org/uniprot/U3CZ55 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:CYBA ^@ http://purl.uniprot.org/uniprot/U3EKP1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the p22phox family.|||Cell membrane|||Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).|||Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.|||Membrane http://togogenome.org/gene/9483:GRM1 ^@ http://purl.uniprot.org/uniprot/F7E693|||http://purl.uniprot.org/uniprot/F7E6E2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:LOC100385973 ^@ http://purl.uniprot.org/uniprot/A0A2R8M646 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/9483:PTGS2 ^@ http://purl.uniprot.org/uniprot/U3DE75 ^@ Caution|||Similarity ^@ Belongs to the prostaglandin G/H synthase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:TNRC6C ^@ http://purl.uniprot.org/uniprot/U3FAC6 ^@ Similarity ^@ Belongs to the GW182 family. http://togogenome.org/gene/9483:SNX11 ^@ http://purl.uniprot.org/uniprot/U3E8B5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane http://togogenome.org/gene/9483:LOC100394098 ^@ http://purl.uniprot.org/uniprot/F7HDB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:APEX1 ^@ http://purl.uniprot.org/uniprot/U3F4F7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Cytoplasm|||Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.|||Mitochondrion|||Nucleus|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/9483:OXSR1 ^@ http://purl.uniprot.org/uniprot/U3BQ56 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. http://togogenome.org/gene/9483:GAREM1 ^@ http://purl.uniprot.org/uniprot/U3EBM3 ^@ Similarity ^@ Belongs to the GAREM family. http://togogenome.org/gene/9483:LOC103790833 ^@ http://purl.uniprot.org/uniprot/F7C9D0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARL2BP family.|||Cytoplasm|||Mitochondrion intermembrane space|||Nucleus|||Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.|||centrosome|||cilium basal body http://togogenome.org/gene/9483:ZSCAN9 ^@ http://purl.uniprot.org/uniprot/U3CI98 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:TBX3 ^@ http://purl.uniprot.org/uniprot/F7HRE2|||http://purl.uniprot.org/uniprot/F7I557 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9483:ZP4 ^@ http://purl.uniprot.org/uniprot/P79159 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZP domain family. ZPB subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Zona pellucida http://togogenome.org/gene/9483:TCEANC2 ^@ http://purl.uniprot.org/uniprot/U3FF24 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:STX19 ^@ http://purl.uniprot.org/uniprot/A0A5F4VYQ5 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9483:RNASE3 ^@ http://purl.uniprot.org/uniprot/F7HVT5 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9483:CDH6 ^@ http://purl.uniprot.org/uniprot/F7IMY6 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:GALNT13 ^@ http://purl.uniprot.org/uniprot/U3BX46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:WDR46 ^@ http://purl.uniprot.org/uniprot/U3D6H3 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9483:CD9 ^@ http://purl.uniprot.org/uniprot/U3DYG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Cell membrane|||Membrane|||extracellular exosome http://togogenome.org/gene/9483:FUT10 ^@ http://purl.uniprot.org/uniprot/U3EP63 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Membrane|||Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. http://togogenome.org/gene/9483:LOC100412562 ^@ http://purl.uniprot.org/uniprot/A0A7G0X101 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9483:TLR10 ^@ http://purl.uniprot.org/uniprot/F6X6W2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9483:ARL11 ^@ http://purl.uniprot.org/uniprot/F7HAY2 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9483:GDE1 ^@ http://purl.uniprot.org/uniprot/F7I4Y1 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9483:SLC35C2 ^@ http://purl.uniprot.org/uniprot/U3BE49 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:ZDHHC15 ^@ http://purl.uniprot.org/uniprot/A0A8I3W786 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9483:HBEGF ^@ http://purl.uniprot.org/uniprot/U3DCM7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:KCNH8 ^@ http://purl.uniprot.org/uniprot/F7F3H8 ^@ Subcellular Location Annotation|||Subunit ^@ Membrane|||The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. http://togogenome.org/gene/9483:LOC100395561 ^@ http://purl.uniprot.org/uniprot/F7BIZ6 ^@ Function|||Similarity ^@ Belongs to the calponin family.|||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. http://togogenome.org/gene/9483:NKX2-1 ^@ http://purl.uniprot.org/uniprot/F6R3N0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:MDFIC ^@ http://purl.uniprot.org/uniprot/F7ICM6 ^@ Similarity ^@ Belongs to the MDFI family. http://togogenome.org/gene/9483:ALDH1A3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YLV6 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9483:GALNTL6 ^@ http://purl.uniprot.org/uniprot/U3BZQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:LSM8 ^@ http://purl.uniprot.org/uniprot/A0A8I3WM72 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. http://togogenome.org/gene/9483:IRF1 ^@ http://purl.uniprot.org/uniprot/B0KWP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Nucleus http://togogenome.org/gene/9483:CCL20 ^@ http://purl.uniprot.org/uniprot/U3CWL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9483:SRPRA ^@ http://purl.uniprot.org/uniprot/U3E4N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding SRP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:STRN ^@ http://purl.uniprot.org/uniprot/F7GIV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat striatin family.|||Membrane http://togogenome.org/gene/9483:LOC100396934 ^@ http://purl.uniprot.org/uniprot/F7IIN0 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9483:TMEM200C ^@ http://purl.uniprot.org/uniprot/U3D7K8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM200 family.|||Membrane http://togogenome.org/gene/9483:CYRIB ^@ http://purl.uniprot.org/uniprot/U3F8K8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CYRI family.|||Interacts with RAC1 (GTP-bound form preferentially).|||Membrane http://togogenome.org/gene/9483:PFKFB3 ^@ http://purl.uniprot.org/uniprot/A0A8I3W439|||http://purl.uniprot.org/uniprot/F6WMF5|||http://purl.uniprot.org/uniprot/F7INK2|||http://purl.uniprot.org/uniprot/F7INK3 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/9483:SARAF ^@ http://purl.uniprot.org/uniprot/U3E7B2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SARAF family.|||Endoplasmic reticulum membrane|||Interacts with STIM1; the interaction is inhibit by th interaction of STIM1 with EFHB.|||Membrane|||Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions. http://togogenome.org/gene/9483:LOC100414136 ^@ http://purl.uniprot.org/uniprot/F6VLK0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiA prenyltransferase family.|||Converts protoheme IX and farnesyl diphosphate to heme O.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9483:MED19 ^@ http://purl.uniprot.org/uniprot/F7EJX7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 19 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9483:CPNE8 ^@ http://purl.uniprot.org/uniprot/F6RB22 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9483:SLC22A4 ^@ http://purl.uniprot.org/uniprot/F7EVG4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Basal cell membrane|||Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.|||Interacts with PDZK1. http://togogenome.org/gene/9483:TYROBP ^@ http://purl.uniprot.org/uniprot/U3CY64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TYROBP family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:LYRM4 ^@ http://purl.uniprot.org/uniprot/U3DUB0 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9483:HNRNPU ^@ http://purl.uniprot.org/uniprot/U3EE83|||http://purl.uniprot.org/uniprot/U3F263 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Nucleus http://togogenome.org/gene/9483:OR6X1 ^@ http://purl.uniprot.org/uniprot/F7GP36 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9483:ELOVL3 ^@ http://purl.uniprot.org/uniprot/A0A8I3VZ93 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL3 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||N-Glycosylated.|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9483:IL13 ^@ http://purl.uniprot.org/uniprot/B0KWP3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-4/IL-13 family.|||Interacts with IL13RA2.|||Secreted http://togogenome.org/gene/9483:PYGB ^@ http://purl.uniprot.org/uniprot/U3DDL5 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/9483:KATNB1 ^@ http://purl.uniprot.org/uniprot/U3CR17 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat KATNB1 family.|||Cytoplasm|||Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome. This interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein, microtubules, NDEL1 and PAFAH1B1. Interacts with KATNAL1; this interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.|||Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.|||centrosome|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/9483:BSPRY ^@ http://purl.uniprot.org/uniprot/F6PLW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Nucleus http://togogenome.org/gene/9483:PHF1 ^@ http://purl.uniprot.org/uniprot/F7IR10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Polycomblike family.|||Nucleus http://togogenome.org/gene/9483:UTP11 ^@ http://purl.uniprot.org/uniprot/U3FHA1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UTP11 family.|||Component of the ribosomal small subunit (SSU) processome.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/9483:STON2 ^@ http://purl.uniprot.org/uniprot/A0A2R8N120 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating.|||Belongs to the Stoned B family.|||Cytoplasm|||synaptosome http://togogenome.org/gene/9483:PKMYT1 ^@ http://purl.uniprot.org/uniprot/U3CWB5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:ME2 ^@ http://purl.uniprot.org/uniprot/U3EUL8 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/9483:BICD2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XD79 ^@ Similarity ^@ Belongs to the BicD family. http://togogenome.org/gene/9483:YARS1 ^@ http://purl.uniprot.org/uniprot/F6ZN82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Nucleus http://togogenome.org/gene/9483:PLN ^@ http://purl.uniprot.org/uniprot/F6TR48 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phospholamban family.|||Endoplasmic reticulum membrane|||Homopentamer.|||Membrane|||Mitochondrion membrane|||Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/9483:PDGFC ^@ http://purl.uniprot.org/uniprot/A0A8I3W9P2|||http://purl.uniprot.org/uniprot/F7HUW5|||http://purl.uniprot.org/uniprot/U3DUG3 ^@ Caution|||Similarity ^@ Belongs to the PDGF/VEGF growth factor family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:ELL3 ^@ http://purl.uniprot.org/uniprot/B0KWG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Nucleus http://togogenome.org/gene/9483:MTG2 ^@ http://purl.uniprot.org/uniprot/A0A5F4W3X9|||http://purl.uniprot.org/uniprot/F7HV74 ^@ Similarity ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. http://togogenome.org/gene/9483:NDUFB6 ^@ http://purl.uniprot.org/uniprot/U3BMW5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB6 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:SPRTN ^@ http://purl.uniprot.org/uniprot/U3C485 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Spartan family.|||Chromosome|||Nucleus http://togogenome.org/gene/9483:LOC100403393 ^@ http://purl.uniprot.org/uniprot/U3CN13 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/9483:PTGER4 ^@ http://purl.uniprot.org/uniprot/F6VDJ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with FEM1A.|||Membrane|||Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. http://togogenome.org/gene/9483:RIC8B ^@ http://purl.uniprot.org/uniprot/A0A2R8MZC9|||http://purl.uniprot.org/uniprot/A0A8I3W764|||http://purl.uniprot.org/uniprot/F7H9Q3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the synembryn family.|||Cytoplasm|||Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.|||Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. http://togogenome.org/gene/9483:NDUFB5 ^@ http://purl.uniprot.org/uniprot/F7GBY2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB5 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:MRPL16 ^@ http://purl.uniprot.org/uniprot/F6SEU8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/9483:MRTO4 ^@ http://purl.uniprot.org/uniprot/F6QB78 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the pre-60S ribosomal particle.|||Belongs to the universal ribosomal protein uL10 family.|||Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.|||Cytoplasm|||nucleolus http://togogenome.org/gene/9483:SMARCAL1 ^@ http://purl.uniprot.org/uniprot/A0A5K1TUB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.|||Nucleus http://togogenome.org/gene/9483:SPSB4 ^@ http://purl.uniprot.org/uniprot/F7E873 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPSB family.|||Belongs to the TRIM/RBCC family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:SUGP1 ^@ http://purl.uniprot.org/uniprot/U3E6Y9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:MRGPRF ^@ http://purl.uniprot.org/uniprot/U3ANU3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9483:SNRPG ^@ http://purl.uniprot.org/uniprot/U3EIA4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus|||Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.|||cytosol http://togogenome.org/gene/9483:NUDT21 ^@ http://purl.uniprot.org/uniprot/F7I8U3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family. CPSF5 subfamily.|||Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.|||Cytoplasm|||Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.|||Nucleus http://togogenome.org/gene/9483:GJA4 ^@ http://purl.uniprot.org/uniprot/F7ARL8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9483:FN1 ^@ http://purl.uniprot.org/uniprot/F7HU65|||http://purl.uniprot.org/uniprot/F7HWU2|||http://purl.uniprot.org/uniprot/F7ISE9|||http://purl.uniprot.org/uniprot/U3DSP4|||http://purl.uniprot.org/uniprot/U3EWW1 ^@ Function ^@ Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling. http://togogenome.org/gene/9483:TAF11 ^@ http://purl.uniprot.org/uniprot/F7A607|||http://purl.uniprot.org/uniprot/F7IMF2 ^@ Similarity ^@ Belongs to the TAF11 family. http://togogenome.org/gene/9483:MRPS36 ^@ http://purl.uniprot.org/uniprot/F7HY63 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9483:SLC26A4 ^@ http://purl.uniprot.org/uniprot/F6WCD4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane|||Sodium-independent transporter of chloride and iodide. http://togogenome.org/gene/9483:ACVR1B ^@ http://purl.uniprot.org/uniprot/U3C5A2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9483:PROM1 ^@ http://purl.uniprot.org/uniprot/A0A5F4W3J4|||http://purl.uniprot.org/uniprot/A0A5F4W6B9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prominin family.|||Membrane|||microvillus membrane http://togogenome.org/gene/9483:RPE ^@ http://purl.uniprot.org/uniprot/U3FH05 ^@ Cofactor|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/9483:ADGRG6 ^@ http://purl.uniprot.org/uniprot/A0A8I3WLK5|||http://purl.uniprot.org/uniprot/F6QI92|||http://purl.uniprot.org/uniprot/F7IP60 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:USP21 ^@ http://purl.uniprot.org/uniprot/F7EUN1 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9483:RBM5 ^@ http://purl.uniprot.org/uniprot/A0A8I3WFJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RBM5/RBM10 family.|||Nucleus http://togogenome.org/gene/9483:KPNA4 ^@ http://purl.uniprot.org/uniprot/U3BW75 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9483:NUP88 ^@ http://purl.uniprot.org/uniprot/U3D2R2 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/9483:SPOP ^@ http://purl.uniprot.org/uniprot/F6X846 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tdpoz family.|||Nucleus speckle http://togogenome.org/gene/9483:DPH6 ^@ http://purl.uniprot.org/uniprot/U3BM61 ^@ Function|||Similarity ^@ Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.|||Belongs to the Diphthine--ammonia ligase family. http://togogenome.org/gene/9483:ERO1B ^@ http://purl.uniprot.org/uniprot/U3D8Y7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EROs family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9483:MRPL58 ^@ http://purl.uniprot.org/uniprot/F7HPD3 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9483:ADHFE1 ^@ http://purl.uniprot.org/uniprot/F7H822 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.|||Mitochondrion http://togogenome.org/gene/9483:LOC100415560 ^@ http://purl.uniprot.org/uniprot/A0A8I3X6R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:GLRA3 ^@ http://purl.uniprot.org/uniprot/F7GC00|||http://purl.uniprot.org/uniprot/F7GLH0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/9483:BCAP29 ^@ http://purl.uniprot.org/uniprot/F6RHI2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCAP29/BCAP31 family.|||Endoplasmic reticulum membrane|||Membrane|||Plays a role in the export of secreted proteins in the ER. http://togogenome.org/gene/9483:ZDHHC9 ^@ http://purl.uniprot.org/uniprot/F7HP76 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9483:DDX5 ^@ http://purl.uniprot.org/uniprot/U3CNG4 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily. http://togogenome.org/gene/9483:TFRC ^@ http://purl.uniprot.org/uniprot/H9BFK5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.|||Homodimer; disulfide-linked.|||Melanosome|||Membrane|||Stearoylated. http://togogenome.org/gene/9483:ACTR8 ^@ http://purl.uniprot.org/uniprot/U3CEX0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the actin family. ARP8 subfamily.|||Chromosome|||Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core.|||Nucleus|||Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.|||Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. http://togogenome.org/gene/9483:H1-5 ^@ http://purl.uniprot.org/uniprot/A0A2R8MFI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9483:RFC5 ^@ http://purl.uniprot.org/uniprot/U3BST5 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/9483:SNRNP200 ^@ http://purl.uniprot.org/uniprot/F7IBV6 ^@ Similarity ^@ Belongs to the helicase family. SKI2 subfamily. http://togogenome.org/gene/9483:NDUFS5 ^@ http://purl.uniprot.org/uniprot/F7B8U9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS5 subunit family.|||Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9483:CCR4 ^@ http://purl.uniprot.org/uniprot/F7F2B0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9483:COPB1 ^@ http://purl.uniprot.org/uniprot/F7GQX5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ COPI-coated vesicle membrane|||Cytoplasm|||Endoplasmic reticulum-Golgi intermediate compartment|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/9483:CD28 ^@ http://purl.uniprot.org/uniprot/A0A5F4VR83|||http://purl.uniprot.org/uniprot/A5HJL7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:ATG16L2 ^@ http://purl.uniprot.org/uniprot/F7GNX8 ^@ Similarity ^@ Belongs to the WD repeat ATG16 family. http://togogenome.org/gene/9483:STXBP5 ^@ http://purl.uniprot.org/uniprot/F7E5V3|||http://purl.uniprot.org/uniprot/F7GZ23|||http://purl.uniprot.org/uniprot/U3EYR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat L(2)GL family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9483:ING3 ^@ http://purl.uniprot.org/uniprot/U3BH34 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9483:ATP6V1H ^@ http://purl.uniprot.org/uniprot/U3BXQ6|||http://purl.uniprot.org/uniprot/U3CFY7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase H subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9483:RPL38 ^@ http://purl.uniprot.org/uniprot/A0A5F4W0P3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL38 family. http://togogenome.org/gene/9483:FAH ^@ http://purl.uniprot.org/uniprot/U3CEN7 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/9483:ATP2B1 ^@ http://purl.uniprot.org/uniprot/A0A8I3W2J7|||http://purl.uniprot.org/uniprot/F7E517 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:UCN ^@ http://purl.uniprot.org/uniprot/F7CU67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Secreted http://togogenome.org/gene/9483:CHST11 ^@ http://purl.uniprot.org/uniprot/F7F2M8|||http://purl.uniprot.org/uniprot/U3CLY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:PPP2R2A ^@ http://purl.uniprot.org/uniprot/U3CQ53 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/9483:PKIB ^@ http://purl.uniprot.org/uniprot/A0A5F4W598|||http://purl.uniprot.org/uniprot/A0A8I3X2R3 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/9483:MPG ^@ http://purl.uniprot.org/uniprot/F6QTA1 ^@ Function|||Similarity ^@ Belongs to the DNA glycosylase MPG family.|||Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions. http://togogenome.org/gene/9483:SMAD4 ^@ http://purl.uniprot.org/uniprot/U3E3A5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:CSMD3 ^@ http://purl.uniprot.org/uniprot/F7IB61 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:C22H19orf53 ^@ http://purl.uniprot.org/uniprot/F7AA03 ^@ Function|||Similarity ^@ Belongs to the UPF0390 family.|||May have a potential role in hypercalcemia of malignancy. http://togogenome.org/gene/9483:MOXD1 ^@ http://purl.uniprot.org/uniprot/B0KWA2 ^@ Similarity ^@ Belongs to the copper type II ascorbate-dependent monooxygenase family. http://togogenome.org/gene/9483:LTV1 ^@ http://purl.uniprot.org/uniprot/F7H7Q1 ^@ Similarity ^@ Belongs to the LTV1 family. http://togogenome.org/gene/9483:LOC100389230 ^@ http://purl.uniprot.org/uniprot/A0A2R8MBA7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9483:IFNL3 ^@ http://purl.uniprot.org/uniprot/F7ACE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lambda interferon family.|||Secreted http://togogenome.org/gene/9483:LOC100388427 ^@ http://purl.uniprot.org/uniprot/F7FGL0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9483:SLC25A53 ^@ http://purl.uniprot.org/uniprot/F7GUE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9483:REEP3 ^@ http://purl.uniprot.org/uniprot/F6ZYR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/9483:DYNLRB1 ^@ http://purl.uniprot.org/uniprot/F7IQZ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.|||Belongs to the GAMAD family.|||Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.|||cytoskeleton http://togogenome.org/gene/9483:FOXI2 ^@ http://purl.uniprot.org/uniprot/F7I4R5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:EIF5A2 ^@ http://purl.uniprot.org/uniprot/F6YNW2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Endoplasmic reticulum membrane|||Membrane|||Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.|||eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group. http://togogenome.org/gene/9483:GNG12 ^@ http://purl.uniprot.org/uniprot/F7E106 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9483:PDE1B ^@ http://purl.uniprot.org/uniprot/A0A8I3WF54|||http://purl.uniprot.org/uniprot/F7ISI9|||http://purl.uniprot.org/uniprot/U3DNA4 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9483:ICAM2 ^@ http://purl.uniprot.org/uniprot/F7FBG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. ICAM family.|||Membrane http://togogenome.org/gene/9483:PLA1A ^@ http://purl.uniprot.org/uniprot/A0A5F4VSD8|||http://purl.uniprot.org/uniprot/F7A5P8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9483:CHIT1 ^@ http://purl.uniprot.org/uniprot/F7H9D8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. http://togogenome.org/gene/9483:DDX24 ^@ http://purl.uniprot.org/uniprot/F6SWG1 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9483:RSL24D1 ^@ http://purl.uniprot.org/uniprot/A0A2R8MGE6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/9483:UBE2K ^@ http://purl.uniprot.org/uniprot/F7HJ73|||http://purl.uniprot.org/uniprot/F7HJG5 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9483:IRX6 ^@ http://purl.uniprot.org/uniprot/F7F8E6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/IRO homeobox family.|||Nucleus http://togogenome.org/gene/9483:SLC5A7 ^@ http://purl.uniprot.org/uniprot/F6ZJ07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:SLC25A33 ^@ http://purl.uniprot.org/uniprot/U3E5R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9483:RSAD2 ^@ http://purl.uniprot.org/uniprot/U3B8G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RSAD2 family.|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion inner membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9483:ERP29 ^@ http://purl.uniprot.org/uniprot/F7C9F2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Does not seem to be a disulfide isomerase.|||Endoplasmic reticulum lumen|||Homodimer.|||Melanosome http://togogenome.org/gene/9483:GGTA1 ^@ http://purl.uniprot.org/uniprot/Q8SQ20 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 6 family.|||Binds 1 Mn(2+) ion per subunit.|||Golgi stack membrane|||Synthesizes the galactose-alpha(1,3)-galactose group by catalyzing the transfer of a galactose residue, with an alpha-1,3 linkage, on terminal lactosaminide (Gal-beta-1,4-GlcNAc-R) disaccharide borne by a glycoprotein or a glycolipid. Preferentially glycosylates proteins, can synthesize galactose-alpha(1,3)-galactose on glycoproteins but cannot synthesize the glycolipid called isoglobotrihexosylceramide or isogloboside 3 (iGb3) (By similarity).|||The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis (By similarity). http://togogenome.org/gene/9483:TGIF1 ^@ http://purl.uniprot.org/uniprot/A0A8I3WAA8|||http://purl.uniprot.org/uniprot/F7E4J0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:SCAND3 ^@ http://purl.uniprot.org/uniprot/F7IK96 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:SETDB2 ^@ http://purl.uniprot.org/uniprot/U3D7Z6 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/9483:CAPN7 ^@ http://purl.uniprot.org/uniprot/F7D1T2 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9483:TIMM8A ^@ http://purl.uniprot.org/uniprot/U3D825 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9483:LOC100412910 ^@ http://purl.uniprot.org/uniprot/F7GP74 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/9483:APOOL ^@ http://purl.uniprot.org/uniprot/U3BZQ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:LOC100414611 ^@ http://purl.uniprot.org/uniprot/A0A2R8M558 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9483:PPP6R2 ^@ http://purl.uniprot.org/uniprot/U3DCX6 ^@ Similarity ^@ Belongs to the SAPS family. http://togogenome.org/gene/9483:TNP2 ^@ http://purl.uniprot.org/uniprot/A0A2R8PMU4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear transition protein 2 family.|||Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.|||nucleolus http://togogenome.org/gene/9483:NSUN6 ^@ http://purl.uniprot.org/uniprot/F7EM71 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/9483:DXO ^@ http://purl.uniprot.org/uniprot/F6XJ66 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DXO/Dom3Z family.|||Binds 2 magnesium ions.|||Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.|||Nucleus http://togogenome.org/gene/9483:CHRNB3 ^@ http://purl.uniprot.org/uniprot/F7IIU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9483:FAM168B ^@ http://purl.uniprot.org/uniprot/F7GKM9 ^@ Similarity ^@ Belongs to the FAM168 family. http://togogenome.org/gene/9483:HSD17B2 ^@ http://purl.uniprot.org/uniprot/F6VR90 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9483:CCKBR ^@ http://purl.uniprot.org/uniprot/A0A2R8NCK1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9483:SLC5A9 ^@ http://purl.uniprot.org/uniprot/U3BD27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:GIMAP7 ^@ http://purl.uniprot.org/uniprot/A0A8I3WYG6 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9483:NDUFB9 ^@ http://purl.uniprot.org/uniprot/F6S3Y1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I LYR family.|||Mammalian complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:CFL2 ^@ http://purl.uniprot.org/uniprot/F7DMB4 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. http://togogenome.org/gene/9483:LOC100402206 ^@ http://purl.uniprot.org/uniprot/A0A2R8PKP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:FAM219B ^@ http://purl.uniprot.org/uniprot/F7AKV0 ^@ Similarity ^@ Belongs to the FAM219 family. http://togogenome.org/gene/9483:MRPL47 ^@ http://purl.uniprot.org/uniprot/F7GBP5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/9483:NDUFA1 ^@ http://purl.uniprot.org/uniprot/F7HZE3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA1 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:H1-4 ^@ http://purl.uniprot.org/uniprot/U3D8R6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9483:LOC100406123 ^@ http://purl.uniprot.org/uniprot/F7I7Z9 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9483:CENPO ^@ http://purl.uniprot.org/uniprot/A0A2R8MYD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-O/MCM21 family.|||Nucleus http://togogenome.org/gene/9483:WDR44 ^@ http://purl.uniprot.org/uniprot/U3E400 ^@ Subcellular Location Annotation ^@ trans-Golgi network http://togogenome.org/gene/9483:SYNGR2 ^@ http://purl.uniprot.org/uniprot/F7H8R3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptogyrin family.|||Membrane http://togogenome.org/gene/9483:WASHC3 ^@ http://purl.uniprot.org/uniprot/A0A8I4A1Z1|||http://purl.uniprot.org/uniprot/U3FE08 ^@ Similarity ^@ Belongs to the CCDC53 family. http://togogenome.org/gene/9483:CNOT8 ^@ http://purl.uniprot.org/uniprot/F7HP79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/9483:S100A2 ^@ http://purl.uniprot.org/uniprot/F6ZM10 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9483:MTMR9 ^@ http://purl.uniprot.org/uniprot/A0A2R8M2R3|||http://purl.uniprot.org/uniprot/A0A5F4WMP3|||http://purl.uniprot.org/uniprot/F7H906 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9483:PIGW ^@ http://purl.uniprot.org/uniprot/U3DL47 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGW family.|||Endoplasmic reticulum membrane|||Membrane|||Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. http://togogenome.org/gene/9483:ARL5A ^@ http://purl.uniprot.org/uniprot/F7FTL5 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9483:TMEM167A ^@ http://purl.uniprot.org/uniprot/F7CZW0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KISH family.|||Golgi apparatus membrane|||Involved in the early part of the secretory pathway.|||Membrane http://togogenome.org/gene/9483:C9H12orf75 ^@ http://purl.uniprot.org/uniprot/F7HDD5 ^@ Similarity ^@ Belongs to the OCC1 family. http://togogenome.org/gene/9483:DRD1 ^@ http://purl.uniprot.org/uniprot/F7GPB6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.|||Membrane|||dendritic spine http://togogenome.org/gene/9483:LOC100386315 ^@ http://purl.uniprot.org/uniprot/F7I9W2 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.|||Belongs to the universal ribosomal protein uS2 family.|||Cell membrane|||Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.|||Cytoplasm|||Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.|||Nucleus|||Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.|||This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. http://togogenome.org/gene/9483:USP14 ^@ http://purl.uniprot.org/uniprot/U3DHC9|||http://purl.uniprot.org/uniprot/U3DSU1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the peptidase C19 family. USP14/UBP6 subfamily.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Interacts with TRIM14; this interaction recruits USP14 to cleave ubiquitin chains of CGAS. http://togogenome.org/gene/9483:C7H1orf52 ^@ http://purl.uniprot.org/uniprot/U3D9T0 ^@ Similarity ^@ Belongs to the UPF0690 family. http://togogenome.org/gene/9483:RPL18A ^@ http://purl.uniprot.org/uniprot/A0A5F4WIS8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL20 family. http://togogenome.org/gene/9483:TLCD1 ^@ http://purl.uniprot.org/uniprot/F7EJ17 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:DDAH2 ^@ http://purl.uniprot.org/uniprot/U3E282 ^@ Function|||Similarity ^@ Belongs to the DDAH family.|||Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. http://togogenome.org/gene/9483:EDA2R ^@ http://purl.uniprot.org/uniprot/A0A8J8YCF7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:PNPLA4 ^@ http://purl.uniprot.org/uniprot/A0A8I3X3T3|||http://purl.uniprot.org/uniprot/F7FNR1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:EIF3J ^@ http://purl.uniprot.org/uniprot/F7A6T5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit J family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA.|||Cytoplasm|||Phosphorylated. Phosphorylation is enhanced upon serum stimulation. http://togogenome.org/gene/9483:RPS6KB1 ^@ http://purl.uniprot.org/uniprot/F7GCV0|||http://purl.uniprot.org/uniprot/F7IIP5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9483:CLP1 ^@ http://purl.uniprot.org/uniprot/U3BTP7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Clp1 family. Clp1 subfamily.|||Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54. Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK.|||Nucleus|||Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing. http://togogenome.org/gene/9483:LOC100388510 ^@ http://purl.uniprot.org/uniprot/A0A7G3HQ39 ^@ Similarity|||Subunit ^@ Belongs to the GST superfamily. Theta family.|||Homodimer. http://togogenome.org/gene/9483:TM4SF4 ^@ http://purl.uniprot.org/uniprot/A0A8I4A5Y4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9483:ATIC ^@ http://purl.uniprot.org/uniprot/U3CG69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PurH family.|||cytosol http://togogenome.org/gene/9483:TBX18 ^@ http://purl.uniprot.org/uniprot/A0A2R8MFR8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9483:GFM2 ^@ http://purl.uniprot.org/uniprot/U3D1H4|||http://purl.uniprot.org/uniprot/U3F9Q1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.|||Mitochondrion http://togogenome.org/gene/9483:UBE2D4 ^@ http://purl.uniprot.org/uniprot/U3E9V5 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9483:TBCB ^@ http://purl.uniprot.org/uniprot/F7IEI4 ^@ Similarity ^@ Belongs to the TBCB family. http://togogenome.org/gene/9483:MYOZ2 ^@ http://purl.uniprot.org/uniprot/F7IED9 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/9483:MFSD11 ^@ http://purl.uniprot.org/uniprot/F6PYN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/9483:CCNA2 ^@ http://purl.uniprot.org/uniprot/F7ILU7 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin AB subfamily. http://togogenome.org/gene/9483:SEC63 ^@ http://purl.uniprot.org/uniprot/A0A8I3WE90|||http://purl.uniprot.org/uniprot/B0KWH2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:SLC6A7 ^@ http://purl.uniprot.org/uniprot/F7GHJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9483:CPEB4 ^@ http://purl.uniprot.org/uniprot/F7E421|||http://purl.uniprot.org/uniprot/F7E446|||http://purl.uniprot.org/uniprot/F7E4E6 ^@ Similarity ^@ Belongs to the RRM CPEB family. http://togogenome.org/gene/9483:SBDS ^@ http://purl.uniprot.org/uniprot/F6QRM2 ^@ Function|||Similarity ^@ Belongs to the SDO1/SBDS family.|||Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. http://togogenome.org/gene/9483:TLCD4 ^@ http://purl.uniprot.org/uniprot/U3CVH9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:MYO5C ^@ http://purl.uniprot.org/uniprot/U3BDP9 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9483:TNFAIP8L2 ^@ http://purl.uniprot.org/uniprot/B0KWC3 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Plays a regulatory role in the Toll-like signaling pathway by determining the strength of LPS-induced signaling and gene expression (By similarity). Inhibits TCR-mediated T-cell activation and negatively regulate T-cell function to prevent hyperresponsiveness (By similarity). Inhibits also autolysosome formation via negatively modulating MTOR activation by interacting with RAC1 and promoting the disassociation of the RAC1-MTOR complex (By similarity). Plays an essential role in NK-cell biology by acting as a checkpoint and displaying an expression pattern correlating with NK-cell maturation process and by negatively regulating NK-cell maturation and antitumor immunity (By similarity). Mechanistically, suppresses IL-15-triggered mTOR activity in NK-cells (By similarity).|||Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.|||Cytoplasm|||Lysosome|||May interact with CASP8; however, such result is unclear since could not reproduce the interaction with CASP8. Interacts with RAC1.|||Nucleus|||Phosphorylated by TAK1/MAP3K7; this phosphorylation triggers association with BTRC and subsequent ubiquitination and degradation.|||The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding (By similarity).|||Ubiquitinated in a BTRC-depdent manner; leading to degradation mediated through the proteasome pathway. http://togogenome.org/gene/9483:CCR7 ^@ http://purl.uniprot.org/uniprot/A0A8I3W856 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9483:TAS2R41 ^@ http://purl.uniprot.org/uniprot/F7I726 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9483:MKX ^@ http://purl.uniprot.org/uniprot/F7FZ99 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:PRKAB2 ^@ http://purl.uniprot.org/uniprot/F6YM87 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/9483:SCARA5 ^@ http://purl.uniprot.org/uniprot/F6UGK9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCARA5 family.|||Cell membrane|||Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).|||Homotrimer.|||Membrane http://togogenome.org/gene/9483:VPS33B ^@ http://purl.uniprot.org/uniprot/F7IRH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STXBP/unc-18/SEC1 family.|||Early endosome|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||clathrin-coated vesicle http://togogenome.org/gene/9483:MMP26 ^@ http://purl.uniprot.org/uniprot/F6W5T8 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9483:SNRPC ^@ http://purl.uniprot.org/uniprot/U3BKR1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the U1 small nuclear ribonucleoprotein C family.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Nucleus|||U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. http://togogenome.org/gene/9483:ALDH18A1 ^@ http://purl.uniprot.org/uniprot/F7HR79|||http://purl.uniprot.org/uniprot/U3B9D8 ^@ Similarity ^@ In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.|||In the N-terminal section; belongs to the glutamate 5-kinase family. http://togogenome.org/gene/9483:SLC7A3 ^@ http://purl.uniprot.org/uniprot/F6S3I4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:BCAS2 ^@ http://purl.uniprot.org/uniprot/F7HWK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPF27 family.|||Nucleus http://togogenome.org/gene/9483:TCP1 ^@ http://purl.uniprot.org/uniprot/U3CAP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||centrosome http://togogenome.org/gene/9483:CD93 ^@ http://purl.uniprot.org/uniprot/A0A8I3WL84 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:RORA ^@ http://purl.uniprot.org/uniprot/U3FGL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9483:CDK5R1 ^@ http://purl.uniprot.org/uniprot/F7DFC5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cyclin-dependent kinase 5 activator family.|||Cell membrane|||Heterodimer of a catalytic subunit and a regulatory subunit.|||Membrane http://togogenome.org/gene/9483:DNAJA1 ^@ http://purl.uniprot.org/uniprot/F7I6Q8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:BTF3L4 ^@ http://purl.uniprot.org/uniprot/F7I0E1 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/9483:TNFSF4 ^@ http://purl.uniprot.org/uniprot/F7IAD3 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9483:MED10 ^@ http://purl.uniprot.org/uniprot/F7DB49 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 10 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9483:S100A4 ^@ http://purl.uniprot.org/uniprot/U3F5Z7 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9483:TOMM22 ^@ http://purl.uniprot.org/uniprot/F6TSD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom22 family.|||Mitochondrion outer membrane http://togogenome.org/gene/9483:PLP1 ^@ http://purl.uniprot.org/uniprot/F7F5H2|||http://purl.uniprot.org/uniprot/U3BKX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/9483:DSE ^@ http://purl.uniprot.org/uniprot/A0A8I3X984 ^@ Similarity ^@ Belongs to the dermatan-sulfate isomerase family. http://togogenome.org/gene/9483:PENK ^@ http://purl.uniprot.org/uniprot/F6WU13 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the opioid neuropeptide precursor family.|||Increases glutamate release in the striatum and decreases GABA concentration in the striatum.|||Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.|||Secreted|||chromaffin granule lumen http://togogenome.org/gene/9483:SNX21 ^@ http://purl.uniprot.org/uniprot/F7HVT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome membrane|||Membrane http://togogenome.org/gene/9483:ODF1 ^@ http://purl.uniprot.org/uniprot/A0A8I3W4R6 ^@ Function ^@ Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. http://togogenome.org/gene/9483:LOC100398983 ^@ http://purl.uniprot.org/uniprot/U3EG95 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. Interacts with RNPS1. Interacts with the SRP receptor subunit SRPRA.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development.|||Cytoplasm|||Endoplasmic reticulum|||Nucleus speckle|||The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.|||The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER. http://togogenome.org/gene/9483:VPS18 ^@ http://purl.uniprot.org/uniprot/F7IT14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS18 family.|||Membrane http://togogenome.org/gene/9483:SEMA3D ^@ http://purl.uniprot.org/uniprot/F7D0I7 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:TGFB1 ^@ http://purl.uniprot.org/uniprot/U3D3J1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.|||extracellular matrix http://togogenome.org/gene/9483:MPP3 ^@ http://purl.uniprot.org/uniprot/F6SGV1 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/9483:RAB3A ^@ http://purl.uniprot.org/uniprot/F6WFR3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/9483:SCN2A ^@ http://purl.uniprot.org/uniprot/U3FV47 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel (TC 1.A.1.10) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.|||Membrane http://togogenome.org/gene/9483:RTF2 ^@ http://purl.uniprot.org/uniprot/F7I571 ^@ Similarity|||Subunit ^@ Belongs to the rtf2 family.|||Interacts with DDI2; probably also interacts with DDI1. http://togogenome.org/gene/9483:RNFT2 ^@ http://purl.uniprot.org/uniprot/A0A8I3WH16|||http://purl.uniprot.org/uniprot/F7IRH7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:SUSD5 ^@ http://purl.uniprot.org/uniprot/A0A2R8P1M3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:CAND1 ^@ http://purl.uniprot.org/uniprot/F6XT20 ^@ Similarity ^@ Belongs to the CAND family. http://togogenome.org/gene/9483:PDGFRA ^@ http://purl.uniprot.org/uniprot/F6VUA7 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.|||Membrane|||Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.|||Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. http://togogenome.org/gene/9483:GTF2H4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XII6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB2 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.|||Nucleus http://togogenome.org/gene/9483:DLK2 ^@ http://purl.uniprot.org/uniprot/F7BVC0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:SLC25A40 ^@ http://purl.uniprot.org/uniprot/U3F7R9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:DLL4 ^@ http://purl.uniprot.org/uniprot/A0A2R8PCZ4 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/9483:DNM2 ^@ http://purl.uniprot.org/uniprot/F7GCH1|||http://purl.uniprot.org/uniprot/U3EAV4|||http://purl.uniprot.org/uniprot/U3ELC4 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/9483:HS6ST2 ^@ http://purl.uniprot.org/uniprot/F6S5X6|||http://purl.uniprot.org/uniprot/U3CB80 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.|||Belongs to the sulfotransferase 6 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:JUN ^@ http://purl.uniprot.org/uniprot/U3ED65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. Jun subfamily.|||Nucleus http://togogenome.org/gene/9483:LOC100395853 ^@ http://purl.uniprot.org/uniprot/A0A8I3X4M8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9483:MTHFD2L ^@ http://purl.uniprot.org/uniprot/F6ZFR0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.|||Bifunctional mitochondrial folate-interconverting enzyme that has both NAD/NADP-dependent methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:PIK3R1 ^@ http://purl.uniprot.org/uniprot/F7IP48|||http://purl.uniprot.org/uniprot/F7IP49|||http://purl.uniprot.org/uniprot/U3ERL3 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/9483:SERPINI1 ^@ http://purl.uniprot.org/uniprot/U3EYE3 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9483:TOB2 ^@ http://purl.uniprot.org/uniprot/F7HNT3 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9483:TSPAN2 ^@ http://purl.uniprot.org/uniprot/A0A2R8MT59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9483:TRIM33 ^@ http://purl.uniprot.org/uniprot/F7I5Z0|||http://purl.uniprot.org/uniprot/F7I621 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:SNX4 ^@ http://purl.uniprot.org/uniprot/U3DS06 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9483:SLC7A10 ^@ http://purl.uniprot.org/uniprot/F6W3J6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:P2RY2 ^@ http://purl.uniprot.org/uniprot/F7IT87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:PGLYRP2 ^@ http://purl.uniprot.org/uniprot/F6XHP9 ^@ Similarity ^@ Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. http://togogenome.org/gene/9483:IMMP2L ^@ http://purl.uniprot.org/uniprot/U3AWW4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26 family. IMP2 subfamily.|||Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.|||Heterodimer of 2 subunits, IMMPL1 and IMMPL2.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9483:FUBP1 ^@ http://purl.uniprot.org/uniprot/A0A8I3WEM8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:LOC100400489 ^@ http://purl.uniprot.org/uniprot/A0A5F4W184 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9483:NCBP2 ^@ http://purl.uniprot.org/uniprot/F7B893 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRM NCBP2 family.|||Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.|||Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.|||Nucleus http://togogenome.org/gene/9483:PARN ^@ http://purl.uniprot.org/uniprot/U3D8R3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Cytoplasm http://togogenome.org/gene/9483:IDH3A ^@ http://purl.uniprot.org/uniprot/U3E4Q8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.|||Mitochondrion http://togogenome.org/gene/9483:CCNT1 ^@ http://purl.uniprot.org/uniprot/F7I6V2 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9483:VAMP8 ^@ http://purl.uniprot.org/uniprot/A0A8I3VZ65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9483:MRPS14 ^@ http://purl.uniprot.org/uniprot/U3DJ52 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS14 family. http://togogenome.org/gene/9483:S100A6 ^@ http://purl.uniprot.org/uniprot/F6W664 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the S-100 family.|||May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.|||Nucleus envelope http://togogenome.org/gene/9483:MGP ^@ http://purl.uniprot.org/uniprot/F7INT5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.|||Belongs to the osteocalcin/matrix Gla protein family.|||Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.|||Requires vitamin K-dependent gamma-carboxylation for its function.|||Secreted http://togogenome.org/gene/9483:FGF23 ^@ http://purl.uniprot.org/uniprot/A0A8I3WME0 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9483:EZH2 ^@ http://purl.uniprot.org/uniprot/A0A5K1USM6|||http://purl.uniprot.org/uniprot/U3DM49 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:NLGN1 ^@ http://purl.uniprot.org/uniprot/U3FSR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:EPHA3 ^@ http://purl.uniprot.org/uniprot/U3DED6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:RFC4 ^@ http://purl.uniprot.org/uniprot/U3CKN0 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/9483:ASF1A ^@ http://purl.uniprot.org/uniprot/F6QXV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/9483:LOC100395849 ^@ http://purl.uniprot.org/uniprot/B0VXL1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/9483:KIF16B ^@ http://purl.uniprot.org/uniprot/A0A2R8NDI8|||http://purl.uniprot.org/uniprot/F7HM80|||http://purl.uniprot.org/uniprot/U3E809 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9483:RPL13A ^@ http://purl.uniprot.org/uniprot/F7EY23 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/9483:EVA1C ^@ http://purl.uniprot.org/uniprot/B0VXF8|||http://purl.uniprot.org/uniprot/U3DF70 ^@ Similarity ^@ Belongs to the EVA1 family. http://togogenome.org/gene/9483:PRDX2 ^@ http://purl.uniprot.org/uniprot/U3BQQ2 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/9483:UBL4A ^@ http://purl.uniprot.org/uniprot/B0KWT6|||http://purl.uniprot.org/uniprot/U3DZM8 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.|||Component of the BAG6/BAT3 complex, at least composed of BAG6, UBL4A and GET4/TRC35. Interacts with BAG6; the interaction is direct and required for UBL4A protein stability. Interacts with USP13; may be indirect via BAG6.|||Nucleus|||Polyubiquitinated. Ubiquitination by AMFR and deubiquitination by USP13 may regulate the interaction between the BAG6/BAT complex and SGTA and therefore may regulate client proteins fate.|||cytosol http://togogenome.org/gene/9483:TMED9 ^@ http://purl.uniprot.org/uniprot/A0A2R8M2U2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:PLPP3 ^@ http://purl.uniprot.org/uniprot/U3D0U1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9483:WTAP ^@ http://purl.uniprot.org/uniprot/U3E922 ^@ Similarity ^@ Belongs to the fl(2)d family. http://togogenome.org/gene/9483:DHDDS ^@ http://purl.uniprot.org/uniprot/A0A8I3W458|||http://purl.uniprot.org/uniprot/U3CUJ0 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/9483:PTGES ^@ http://purl.uniprot.org/uniprot/F7BE45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Membrane http://togogenome.org/gene/9483:OLFML2A ^@ http://purl.uniprot.org/uniprot/F7H8G8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:PTCD2 ^@ http://purl.uniprot.org/uniprot/F6WCE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTCD2 family.|||Mitochondrion http://togogenome.org/gene/9483:MMP15 ^@ http://purl.uniprot.org/uniprot/U3CVZ5 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9483:DAZAP2 ^@ http://purl.uniprot.org/uniprot/F7FWV5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus speckle|||nuclear body http://togogenome.org/gene/9483:HAUS1 ^@ http://purl.uniprot.org/uniprot/U3FPB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HAUS1 family.|||spindle http://togogenome.org/gene/9483:CCDC126 ^@ http://purl.uniprot.org/uniprot/F7HKB9 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9483:NMBR ^@ http://purl.uniprot.org/uniprot/F7I8P3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:KHDRBS2 ^@ http://purl.uniprot.org/uniprot/F7CWI3 ^@ Similarity ^@ Belongs to the KHDRBS family. http://togogenome.org/gene/9483:CNN3 ^@ http://purl.uniprot.org/uniprot/F7IS17 ^@ Function|||Similarity ^@ Belongs to the calponin family.|||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. http://togogenome.org/gene/9483:PSMB9 ^@ http://purl.uniprot.org/uniprot/F7I2S5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:LOC100894903 ^@ http://purl.uniprot.org/uniprot/A0A8I3WMT9 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9483:AARS1 ^@ http://purl.uniprot.org/uniprot/U3C7R0 ^@ Cofactor|||Domain|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||ISGylated.|||Monomer. Interacts with ANKRD16; the interaction is direct. http://togogenome.org/gene/9483:FAM162B ^@ http://purl.uniprot.org/uniprot/A0A5F4VWJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0389 family.|||Membrane http://togogenome.org/gene/9483:GABRA2 ^@ http://purl.uniprot.org/uniprot/U3DZK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||dendrite http://togogenome.org/gene/9483:CPSF3 ^@ http://purl.uniprot.org/uniprot/F7HIE0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:TMEM50B ^@ http://purl.uniprot.org/uniprot/B0VXG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane http://togogenome.org/gene/9483:TXNL4B ^@ http://purl.uniprot.org/uniprot/F7GNU1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/9483:ASIC3 ^@ http://purl.uniprot.org/uniprot/F6ZWY7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:PLXNC1 ^@ http://purl.uniprot.org/uniprot/U3CZ51 ^@ Caution|||Similarity ^@ Belongs to the plexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:GRHPR ^@ http://purl.uniprot.org/uniprot/U3D1B0 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/9483:MAU2 ^@ http://purl.uniprot.org/uniprot/U3DDI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCC4/mau-2 family.|||nucleoplasm http://togogenome.org/gene/9483:WDR82 ^@ http://purl.uniprot.org/uniprot/F7IDG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SWD2 family.|||Nucleus http://togogenome.org/gene/9483:ATP6V1A ^@ http://purl.uniprot.org/uniprot/A0A8J8XGP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Vesicle|||clathrin-coated vesicle membrane|||secretory vesicle http://togogenome.org/gene/9483:MRPL36 ^@ http://purl.uniprot.org/uniprot/A0A2R8NA09 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/9483:SLC39A9 ^@ http://purl.uniprot.org/uniprot/U3DR82 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Cell membrane|||Membrane|||Mitochondrion|||Nucleus|||Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process.|||perinuclear region|||trans-Golgi network membrane http://togogenome.org/gene/9483:MAPKAP1 ^@ http://purl.uniprot.org/uniprot/F7B3S1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SIN1 family.|||Cytoplasmic vesicle http://togogenome.org/gene/9483:RAB27A ^@ http://purl.uniprot.org/uniprot/F7C0F9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/9483:PADI1 ^@ http://purl.uniprot.org/uniprot/F7IT96 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein arginine deiminase family.|||Catalyzes the deimination of arginine residues of proteins.|||Cytoplasm http://togogenome.org/gene/9483:CAPZA2 ^@ http://purl.uniprot.org/uniprot/Q2QLG4|||http://purl.uniprot.org/uniprot/U3DUR6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit.|||Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5. Interacts with RCSD1/CAPZIP (By similarity). http://togogenome.org/gene/9483:GGPS1 ^@ http://purl.uniprot.org/uniprot/F7EFP1 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9483:LOC100395443 ^@ http://purl.uniprot.org/uniprot/U3EBQ5 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rieske iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster per subunit.|||Membrane|||Mitochondrion inner membrane|||The Rieske protein is a high potential 2Fe-2S protein. http://togogenome.org/gene/9483:MRGPRX1 ^@ http://purl.uniprot.org/uniprot/F7H5A0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9483:NUDC ^@ http://purl.uniprot.org/uniprot/U3FM55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nudC family.|||Midbody|||spindle http://togogenome.org/gene/9483:DNAL4 ^@ http://purl.uniprot.org/uniprot/F6Q578 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/9483:HSPB2 ^@ http://purl.uniprot.org/uniprot/F6ZR37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Nucleus http://togogenome.org/gene/9483:CAMK1G ^@ http://purl.uniprot.org/uniprot/F7G5K6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:MRPS5 ^@ http://purl.uniprot.org/uniprot/A0A5F4W268|||http://purl.uniprot.org/uniprot/F7HP99 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS5 family. http://togogenome.org/gene/9483:CDH9 ^@ http://purl.uniprot.org/uniprot/U3ECE5 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:LOC100410110 ^@ http://purl.uniprot.org/uniprot/F7HAB8 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/9483:POLG2 ^@ http://purl.uniprot.org/uniprot/F7F7L7 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9483:QNG1 ^@ http://purl.uniprot.org/uniprot/A0A8I3W0E7|||http://purl.uniprot.org/uniprot/F7EBM2 ^@ Function|||Similarity ^@ Belongs to the QNG1 protein family.|||Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly. http://togogenome.org/gene/9483:FGF4 ^@ http://purl.uniprot.org/uniprot/F7I9F2 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9483:PMP2 ^@ http://purl.uniprot.org/uniprot/F6S344 ^@ Function|||Similarity|||Subunit ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||May play a role in lipid transport protein in Schwann cells. May bind cholesterol.|||Monomer. http://togogenome.org/gene/9483:CHST12 ^@ http://purl.uniprot.org/uniprot/F7INE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:VSX1 ^@ http://purl.uniprot.org/uniprot/A0A8I3WX80 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:CFAP144 ^@ http://purl.uniprot.org/uniprot/U3BKU9 ^@ Similarity ^@ Belongs to the CFAP144 family. http://togogenome.org/gene/9483:ALX1 ^@ http://purl.uniprot.org/uniprot/A0A8I3WN66 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:NSA2 ^@ http://purl.uniprot.org/uniprot/F7HWF8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.|||Component of the pre-66S ribosomal particle.|||Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.|||nucleolus http://togogenome.org/gene/9483:UBA5 ^@ http://purl.uniprot.org/uniprot/U3DWH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.|||Endoplasmic reticulum membrane|||Golgi apparatus http://togogenome.org/gene/9483:VPS45 ^@ http://purl.uniprot.org/uniprot/U3EPE1 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9483:PPM1D ^@ http://purl.uniprot.org/uniprot/F7IIZ4 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9483:KDR ^@ http://purl.uniprot.org/uniprot/A0A8J8YCV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:SLC50A1 ^@ http://purl.uniprot.org/uniprot/U3CVH4|||http://purl.uniprot.org/uniprot/U3F7F8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SWEET sugar transporter family.|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates sugar transport across membranes.|||Membrane http://togogenome.org/gene/9483:OLFR639 ^@ http://purl.uniprot.org/uniprot/B0VXC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:HBQ1 ^@ http://purl.uniprot.org/uniprot/B0VX79 ^@ Function|||Similarity ^@ Belongs to the globin family.|||Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1. Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling. http://togogenome.org/gene/9483:LOC100387829 ^@ http://purl.uniprot.org/uniprot/A0A2R8P7K0 ^@ Similarity ^@ Belongs to the MARCKS family. http://togogenome.org/gene/9483:AMT ^@ http://purl.uniprot.org/uniprot/U3DTA9|||http://purl.uniprot.org/uniprot/U3F3F4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvT family.|||Mitochondrion|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/9483:LHPP ^@ http://purl.uniprot.org/uniprot/U3D175 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/9483:PTGR1 ^@ http://purl.uniprot.org/uniprot/F7FJC4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADP-dependent oxidoreductase L4BD family.|||Cytoplasm|||Monomer or homodimer. http://togogenome.org/gene/9483:WIF1 ^@ http://purl.uniprot.org/uniprot/U3D640 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9483:PAM16 ^@ http://purl.uniprot.org/uniprot/U3BYV6 ^@ Similarity ^@ Belongs to the TIM16/PAM16 family. http://togogenome.org/gene/9483:CCNC ^@ http://purl.uniprot.org/uniprot/F7ING0 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9483:S100A11 ^@ http://purl.uniprot.org/uniprot/F7DD73 ^@ Function|||Similarity|||Subunit ^@ Belongs to the S-100 family.|||Facilitates the differentiation and the cornification of keratinocytes.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9483:VPS35L ^@ http://purl.uniprot.org/uniprot/F7IR81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS35L family.|||Endosome http://togogenome.org/gene/9483:PPTC7 ^@ http://purl.uniprot.org/uniprot/F7B3T3 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9483:TRNAU1AP ^@ http://purl.uniprot.org/uniprot/F7HVM3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TRSPAP family.|||Cytoplasm|||Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis.|||Nucleus http://togogenome.org/gene/9483:NGF ^@ http://purl.uniprot.org/uniprot/U3CKT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NGF-beta family.|||Secreted http://togogenome.org/gene/9483:NRN1L ^@ http://purl.uniprot.org/uniprot/F7I5C5 ^@ Similarity ^@ Belongs to the neuritin family. http://togogenome.org/gene/9483:VSX2 ^@ http://purl.uniprot.org/uniprot/F7BVN5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:PFAS ^@ http://purl.uniprot.org/uniprot/F7HZR0 ^@ Similarity ^@ In the N-terminal section; belongs to the FGAMS family. http://togogenome.org/gene/9483:MOB1B ^@ http://purl.uniprot.org/uniprot/F7I280 ^@ Similarity ^@ Belongs to the MOB1/phocein family. http://togogenome.org/gene/9483:TIGD7 ^@ http://purl.uniprot.org/uniprot/U3F721 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:PEX10 ^@ http://purl.uniprot.org/uniprot/U3FIL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pex2/pex10/pex12 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9483:YWHAE ^@ http://purl.uniprot.org/uniprot/A0A8I3W8K2|||http://purl.uniprot.org/uniprot/F7GZ27 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9483:RPS6KA3 ^@ http://purl.uniprot.org/uniprot/A0A5F4W771|||http://purl.uniprot.org/uniprot/A0A5F4WM03|||http://purl.uniprot.org/uniprot/F7GWP8|||http://purl.uniprot.org/uniprot/U3D5H3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9483:SCFD1 ^@ http://purl.uniprot.org/uniprot/F7ISQ5 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9483:GEM ^@ http://purl.uniprot.org/uniprot/F7EIY8 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/9483:HAPLN4 ^@ http://purl.uniprot.org/uniprot/A0A8I3VZB5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:CCDC34 ^@ http://purl.uniprot.org/uniprot/F7IKF2 ^@ Subcellular Location Annotation ^@ flagellum http://togogenome.org/gene/9483:AFM ^@ http://purl.uniprot.org/uniprot/A0A5F4VV46 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9483:GALNT7 ^@ http://purl.uniprot.org/uniprot/F7D606|||http://purl.uniprot.org/uniprot/F7I1I2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:TRIM23 ^@ http://purl.uniprot.org/uniprot/U3BWI0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:DCPS ^@ http://purl.uniprot.org/uniprot/U3B9C6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HIT family.|||Cytoplasm|||Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway.|||Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.|||Nucleus http://togogenome.org/gene/9483:TEX10 ^@ http://purl.uniprot.org/uniprot/U3C6J2 ^@ Similarity ^@ Belongs to the IPI1/TEX10 family. http://togogenome.org/gene/9483:GNG3 ^@ http://purl.uniprot.org/uniprot/F7I3K5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9483:VMA21 ^@ http://purl.uniprot.org/uniprot/F6S8Q8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the V0 complex of the vacuolar ATPase (V-ATPase).|||Belongs to the VMA21 family.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum. http://togogenome.org/gene/9483:MBTPS1 ^@ http://purl.uniprot.org/uniprot/U3DTU4 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9483:GABRG3 ^@ http://purl.uniprot.org/uniprot/U3DY73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9483:LOC100396218 ^@ http://purl.uniprot.org/uniprot/F7IPB7 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9483:CSTF2 ^@ http://purl.uniprot.org/uniprot/F7HWT7|||http://purl.uniprot.org/uniprot/F7HWU0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:YTHDF3 ^@ http://purl.uniprot.org/uniprot/U3CP42 ^@ Function|||Similarity ^@ Belongs to the YTHDF family.|||Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. http://togogenome.org/gene/9483:HMGN3 ^@ http://purl.uniprot.org/uniprot/U3C9L4|||http://purl.uniprot.org/uniprot/U3FJW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/9483:DUSP6 ^@ http://purl.uniprot.org/uniprot/A0A2R8MQX9 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9483:HTT ^@ http://purl.uniprot.org/uniprot/B7XBM1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the huntingtin family.|||Cytoplasm|||May play a role in microtubule-mediated transport or vesicle function.|||Nucleus http://togogenome.org/gene/9483:HBE1 ^@ http://purl.uniprot.org/uniprot/B0VXB7|||http://purl.uniprot.org/uniprot/P68026 ^@ Function|||Similarity|||Subunit|||Tissue Specificity ^@ Belongs to the globin family.|||Heterotetramer of two alpha chains and two epsilon chains in early embryonic hemoglobin Gower-2; two zeta chains and two epsilon chains in early embryonic hemoglobin Gower-1.|||Red blood cells.|||The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin. http://togogenome.org/gene/9483:CNIH1 ^@ http://purl.uniprot.org/uniprot/F7CT80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/9483:RFNG ^@ http://purl.uniprot.org/uniprot/F6SII8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:RPL39L ^@ http://purl.uniprot.org/uniprot/A0A8I3W7A5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/9483:STMN1 ^@ http://purl.uniprot.org/uniprot/U3DF36 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/9483:CXXC1 ^@ http://purl.uniprot.org/uniprot/U3DLM1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:CHMP4C ^@ http://purl.uniprot.org/uniprot/F6SNN9|||http://purl.uniprot.org/uniprot/U3FI70 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9483:GTF2H1 ^@ http://purl.uniprot.org/uniprot/A0A8I3W2V2|||http://purl.uniprot.org/uniprot/U3DYN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB1 family.|||Nucleus http://togogenome.org/gene/9483:ARV1 ^@ http://purl.uniprot.org/uniprot/A0A2R8NEP4|||http://purl.uniprot.org/uniprot/F6VUR9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARV1 family.|||Endoplasmic reticulum membrane|||Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.|||Membrane http://togogenome.org/gene/9483:PRPSAP2 ^@ http://purl.uniprot.org/uniprot/U3EA77 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/9483:DUSP26 ^@ http://purl.uniprot.org/uniprot/F7HXW2 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/9483:LOC100394558 ^@ http://purl.uniprot.org/uniprot/B0KW94 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ADP-ribosylated at Tyr-155 by PARP1 in presence of HPF1.|||Belongs to the eukaryotic ribosomal protein eS1 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.|||Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). May play a role during erythropoiesis (By similarity).|||Cytoplasm|||Nucleus|||nucleolus http://togogenome.org/gene/9483:AGRP ^@ http://purl.uniprot.org/uniprot/F7I534 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9483:CYP11B2 ^@ http://purl.uniprot.org/uniprot/A0A8I3WBU5 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9483:DNAJC16 ^@ http://purl.uniprot.org/uniprot/F6XIZ7 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Plays an important role in regulating the size of autophagosomes during the formation process. http://togogenome.org/gene/9483:EFHC1 ^@ http://purl.uniprot.org/uniprot/A0A2R8PDG3 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9483:VAMP3 ^@ http://purl.uniprot.org/uniprot/U3F6I3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9483:BANP ^@ http://purl.uniprot.org/uniprot/A0A2R8MB62|||http://purl.uniprot.org/uniprot/F7E7Q1|||http://purl.uniprot.org/uniprot/U3D2P4|||http://purl.uniprot.org/uniprot/U3FSZ4 ^@ Similarity ^@ Belongs to the BANP/SMAR1 family. http://togogenome.org/gene/9483:SERINC5 ^@ http://purl.uniprot.org/uniprot/A0A2R8M3X6|||http://purl.uniprot.org/uniprot/U3E2A3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9483:CASP14 ^@ http://purl.uniprot.org/uniprot/F7HWS2 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9483:MPDU1 ^@ http://purl.uniprot.org/uniprot/F7GNS7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MPDU1 (TC 2.A.43.3) family.|||Membrane|||Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors. http://togogenome.org/gene/9483:ECSIT ^@ http://purl.uniprot.org/uniprot/U3C180 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.|||Belongs to the ECSIT family.|||Cytoplasm|||Mitochondrion|||Nucleus http://togogenome.org/gene/9483:DPPA2 ^@ http://purl.uniprot.org/uniprot/F6YXD7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:NECAP1 ^@ http://purl.uniprot.org/uniprot/U3CAL7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NECAP family.|||Involved in endocytosis.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9483:CFAP107 ^@ http://purl.uniprot.org/uniprot/F6WMT0 ^@ Function|||Subcellular Location Annotation ^@ Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.|||cilium axoneme http://togogenome.org/gene/9483:PDIA6 ^@ http://purl.uniprot.org/uniprot/U3ERB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen|||Melanosome http://togogenome.org/gene/9483:RPL10A ^@ http://purl.uniprot.org/uniprot/F6XC43 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL1 family. http://togogenome.org/gene/9483:ITGB5 ^@ http://purl.uniprot.org/uniprot/U3FGD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:PAPOLA ^@ http://purl.uniprot.org/uniprot/F7HE64 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the poly(A) polymerase family.|||Binds 2 magnesium ions. Also active with manganese.|||Nucleus|||Polymerase that creates the 3'-poly(A) tail of mRNA's. http://togogenome.org/gene/9483:RPLP2 ^@ http://purl.uniprot.org/uniprot/F6U184 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/9483:SEMA6C ^@ http://purl.uniprot.org/uniprot/U3E605|||http://purl.uniprot.org/uniprot/U3EH97 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:RHBDL1 ^@ http://purl.uniprot.org/uniprot/F6YAM4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S54 family.|||May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.|||Membrane http://togogenome.org/gene/9483:INKA2 ^@ http://purl.uniprot.org/uniprot/F6U9M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INKA family.|||Nucleus http://togogenome.org/gene/9483:TPMT ^@ http://purl.uniprot.org/uniprot/F6PNF2 ^@ Similarity|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.|||Monomer. http://togogenome.org/gene/9483:SERPINC1 ^@ http://purl.uniprot.org/uniprot/F6XBM4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the serpin family.|||Forms protease inhibiting heterodimer with TMPRSS7.|||extracellular space http://togogenome.org/gene/9483:JPH2 ^@ http://purl.uniprot.org/uniprot/F7EC17 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the junctophilin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.|||Membrane http://togogenome.org/gene/9483:AK5 ^@ http://purl.uniprot.org/uniprot/U3F4C9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylate kinase family.|||Cytoplasm http://togogenome.org/gene/9483:UFC1 ^@ http://purl.uniprot.org/uniprot/U3BVZ1 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.|||E1-like enzyme which specifically catalyzes the second step in ufmylation. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. http://togogenome.org/gene/9483:SGCZ ^@ http://purl.uniprot.org/uniprot/F7BV23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/9483:YKT6 ^@ http://purl.uniprot.org/uniprot/F7HXA8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane|||Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity. http://togogenome.org/gene/9483:ALKBH1 ^@ http://purl.uniprot.org/uniprot/F7IM93 ^@ Cofactor|||Similarity ^@ Belongs to the alkB family.|||Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/9483:ELK4 ^@ http://purl.uniprot.org/uniprot/U3FE22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9483:HTR2C ^@ http://purl.uniprot.org/uniprot/F6S1A5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:TRAF2 ^@ http://purl.uniprot.org/uniprot/U3B0E4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/9483:C11H11orf54 ^@ http://purl.uniprot.org/uniprot/A0A8I4A4N5|||http://purl.uniprot.org/uniprot/F6RKF2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.|||Monomer.|||Nucleus http://togogenome.org/gene/9483:IFI6 ^@ http://purl.uniprot.org/uniprot/F7IKE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFI6/IFI27 family.|||Membrane http://togogenome.org/gene/9483:RPS21 ^@ http://purl.uniprot.org/uniprot/F7IE69 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS21 family.|||Component of the 40S small ribosomal subunit.|||Endoplasmic reticulum|||Rough endoplasmic reticulum|||cytosol http://togogenome.org/gene/9483:SYT14 ^@ http://purl.uniprot.org/uniprot/F7GXT6 ^@ Similarity ^@ Belongs to the synaptotagmin family. http://togogenome.org/gene/9483:FUCA1 ^@ http://purl.uniprot.org/uniprot/F7HZM3 ^@ Function|||Similarity|||Subunit ^@ Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.|||Belongs to the glycosyl hydrolase 29 family.|||Homotetramer. http://togogenome.org/gene/9483:KCNG1 ^@ http://purl.uniprot.org/uniprot/F6RE04 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:RRP1B ^@ http://purl.uniprot.org/uniprot/F7IF19 ^@ Similarity ^@ Belongs to the RRP1 family. http://togogenome.org/gene/9483:LOC100397855 ^@ http://purl.uniprot.org/uniprot/F7H563 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:ZNF687 ^@ http://purl.uniprot.org/uniprot/B0KWC0 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9483:TMEM186 ^@ http://purl.uniprot.org/uniprot/F7IJG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM186 family.|||Membrane http://togogenome.org/gene/9483:IFITM5 ^@ http://purl.uniprot.org/uniprot/A0A2R8MEJ4 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9483:CTSL ^@ http://purl.uniprot.org/uniprot/A0A8J8YMX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9483:DHFR ^@ http://purl.uniprot.org/uniprot/F7IFS4 ^@ Similarity ^@ Belongs to the dihydrofolate reductase family. http://togogenome.org/gene/9483:KCNH7 ^@ http://purl.uniprot.org/uniprot/A0A2R8MVL6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:TYR ^@ http://purl.uniprot.org/uniprot/F7GAX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane http://togogenome.org/gene/9483:GOLPH3 ^@ http://purl.uniprot.org/uniprot/F7I3I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLPH3/VPS74 family.|||Golgi stack membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9483:MRPL50 ^@ http://purl.uniprot.org/uniprot/F7I2I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL50 family.|||Mitochondrion http://togogenome.org/gene/9483:RIC3 ^@ http://purl.uniprot.org/uniprot/F6TPK5|||http://purl.uniprot.org/uniprot/U3CIL7 ^@ Similarity ^@ Belongs to the ric-3 family. http://togogenome.org/gene/9483:YEATS4 ^@ http://purl.uniprot.org/uniprot/F7HFQ0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:EPDR1 ^@ http://purl.uniprot.org/uniprot/U3DYH2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ependymin family.|||Binds anionic lipids and gangliosides at acidic pH.|||Lysosome lumen|||Secreted http://togogenome.org/gene/9483:SRD5A1 ^@ http://purl.uniprot.org/uniprot/A0A5F4WHZ2|||http://purl.uniprot.org/uniprot/F6XII1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.|||Membrane|||Microsome membrane http://togogenome.org/gene/9483:LDB1 ^@ http://purl.uniprot.org/uniprot/F7ECI5|||http://purl.uniprot.org/uniprot/U3FLV7 ^@ Similarity ^@ Belongs to the LDB family. http://togogenome.org/gene/9483:HOXD1 ^@ http://purl.uniprot.org/uniprot/F7EML3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Labial subfamily.|||Nucleus http://togogenome.org/gene/9483:RPS8 ^@ http://purl.uniprot.org/uniprot/F6PPW3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS8 family. http://togogenome.org/gene/9483:DRAM2 ^@ http://purl.uniprot.org/uniprot/F7GN83 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:NANOS2 ^@ http://purl.uniprot.org/uniprot/A0A2R8M6M2 ^@ Similarity ^@ Belongs to the nanos family. http://togogenome.org/gene/9483:TSEN34 ^@ http://purl.uniprot.org/uniprot/B0VXI7|||http://purl.uniprot.org/uniprot/U3EXA3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA-intron endonuclease family.|||Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.|||Nucleus http://togogenome.org/gene/9483:LOC100387227 ^@ http://purl.uniprot.org/uniprot/A0A509EP45 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/9483:ZKSCAN5 ^@ http://purl.uniprot.org/uniprot/F7IPF4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:OLFR599 ^@ http://purl.uniprot.org/uniprot/B0VXA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:IWS1 ^@ http://purl.uniprot.org/uniprot/F7EW11|||http://purl.uniprot.org/uniprot/U3DIT9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:IPO4 ^@ http://purl.uniprot.org/uniprot/U3ESP2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:ABCF2 ^@ http://purl.uniprot.org/uniprot/F6YVA2 ^@ Subunit ^@ Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and NHERF1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through NHERF1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation. http://togogenome.org/gene/9483:AUP1 ^@ http://purl.uniprot.org/uniprot/F7D4B8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AUP1 family.|||Membrane http://togogenome.org/gene/9483:PCSK7 ^@ http://purl.uniprot.org/uniprot/F7ISH0 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9483:SCUBE2 ^@ http://purl.uniprot.org/uniprot/A0A2R8N1C5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9483:SSH3 ^@ http://purl.uniprot.org/uniprot/F7CT12 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. http://togogenome.org/gene/9483:CCNO ^@ http://purl.uniprot.org/uniprot/F7GQ68 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9483:CCL3L3 ^@ http://purl.uniprot.org/uniprot/F7HEP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9483:DGAT1 ^@ http://purl.uniprot.org/uniprot/A0A5F4W2M8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Homodimer or homotetramer; both forms have similar enzymatic activities.|||Membrane http://togogenome.org/gene/9483:ADRB1 ^@ http://purl.uniprot.org/uniprot/F7GC16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:DES ^@ http://purl.uniprot.org/uniprot/B0KWJ0 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9483:SRP19 ^@ http://purl.uniprot.org/uniprot/F6V6L2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP19 family.|||Cytoplasm http://togogenome.org/gene/9483:SLC33A1 ^@ http://purl.uniprot.org/uniprot/F6ZYC7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:ARMCX2 ^@ http://purl.uniprot.org/uniprot/F7GD48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eutherian X-chromosome-specific Armcx family.|||Membrane http://togogenome.org/gene/9483:ATP8B2 ^@ http://purl.uniprot.org/uniprot/A0A2R8P539 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9483:PPFIA3 ^@ http://purl.uniprot.org/uniprot/F7D8Z7|||http://purl.uniprot.org/uniprot/F7D921 ^@ Similarity ^@ Belongs to the liprin family. Liprin-alpha subfamily. http://togogenome.org/gene/9483:BNIP3L ^@ http://purl.uniprot.org/uniprot/A0A8I3W950 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIP3 family.|||Membrane http://togogenome.org/gene/9483:UFL1 ^@ http://purl.uniprot.org/uniprot/F7ILA7 ^@ Similarity ^@ Belongs to the UFL1 family. http://togogenome.org/gene/9483:SLC30A3 ^@ http://purl.uniprot.org/uniprot/F6XQY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9483:NTF3 ^@ http://purl.uniprot.org/uniprot/A0A2R8PFD8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NGF-beta family.|||Secreted|||Seems to promote the survival of visceral and proprioceptive sensory neurons. http://togogenome.org/gene/9483:MMRN1 ^@ http://purl.uniprot.org/uniprot/F7GB72 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:LXN ^@ http://purl.uniprot.org/uniprot/F6QAW6 ^@ Similarity ^@ Belongs to the protease inhibitor I47 (latexin) family. http://togogenome.org/gene/9483:ORC6 ^@ http://purl.uniprot.org/uniprot/A0A2R8MFH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC6 family.|||Nucleus http://togogenome.org/gene/9483:SNTG1 ^@ http://purl.uniprot.org/uniprot/U3D7X4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntrophin family.|||cytoskeleton http://togogenome.org/gene/9483:HYAL2 ^@ http://purl.uniprot.org/uniprot/F7HIH6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/9483:LYN ^@ http://purl.uniprot.org/uniprot/U3D0I6|||http://purl.uniprot.org/uniprot/U3DUJ3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9483:ATP5PD ^@ http://purl.uniprot.org/uniprot/U3ECF9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase d subunit family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:A1CF ^@ http://purl.uniprot.org/uniprot/F7I3P8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:ARL6 ^@ http://purl.uniprot.org/uniprot/U3EQH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||cilium membrane http://togogenome.org/gene/9483:PLPPR1 ^@ http://purl.uniprot.org/uniprot/F7I2M9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9483:LAMTOR3 ^@ http://purl.uniprot.org/uniprot/F6WBU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR3 family.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/9483:TRPM3 ^@ http://purl.uniprot.org/uniprot/F7IBI8|||http://purl.uniprot.org/uniprot/F7IDP9|||http://purl.uniprot.org/uniprot/U3CRR3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:PTPRG ^@ http://purl.uniprot.org/uniprot/U3EX09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.|||Membrane http://togogenome.org/gene/9483:CDKN3 ^@ http://purl.uniprot.org/uniprot/F6X5L7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family.|||May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues.|||perinuclear region http://togogenome.org/gene/9483:NETO2 ^@ http://purl.uniprot.org/uniprot/U3F8R6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:SMPD2 ^@ http://purl.uniprot.org/uniprot/F7I8K1 ^@ Similarity ^@ Belongs to the neutral sphingomyelinase family. http://togogenome.org/gene/9483:MRPL13 ^@ http://purl.uniprot.org/uniprot/F7GRV5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/9483:TSPAN33 ^@ http://purl.uniprot.org/uniprot/U3DV06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9483:GATM ^@ http://purl.uniprot.org/uniprot/U3CX04 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the amidinotransferase family.|||Homodimer.|||Mitochondrion inner membrane|||Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives. Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain. http://togogenome.org/gene/9483:CNPY2 ^@ http://purl.uniprot.org/uniprot/F7H125 ^@ Similarity ^@ Belongs to the canopy family. http://togogenome.org/gene/9483:SPTLC2 ^@ http://purl.uniprot.org/uniprot/F7IPL5 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9483:LACTB2 ^@ http://purl.uniprot.org/uniprot/F7I4J0 ^@ Function|||Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.|||Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability. http://togogenome.org/gene/9483:WNT7A ^@ http://purl.uniprot.org/uniprot/Q1KYK6|||http://purl.uniprot.org/uniprot/U3CFU1 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Wnt family.|||Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity. The complex with AFM may represent the physiological form in body fluids (By similarity). Interacts with FZD5. Interacts with PORCN (By similarity). Interacts (via intrinsically disordered linker region) with RECK; interaction with RECK confers ligand selectivity for Wnt7 in brain endothelial cells and allows these cells to selectively respond to Wnt7 (By similarity).|||Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal neural stem cell proliferation in the hippocampus dentate gyrus. Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation. Promotes formation of synapses via its interaction with FZD5 (By similarity).|||Ligand for members of the frizzled family of seven transmembrane receptors.|||Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.|||Secreted|||The intrinsically disordered linker region is required for recognition by RECK in brain endothelial cells.|||extracellular matrix http://togogenome.org/gene/9483:FAM76B ^@ http://purl.uniprot.org/uniprot/F6Y823 ^@ Similarity ^@ Belongs to the FAM76 family. http://togogenome.org/gene/9483:ZDHHC13 ^@ http://purl.uniprot.org/uniprot/U3DKA5 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9483:CTSV ^@ http://purl.uniprot.org/uniprot/A0A2R8M4M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9483:LTBP1 ^@ http://purl.uniprot.org/uniprot/U3C3V5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9483:ATP5MG ^@ http://purl.uniprot.org/uniprot/F7GSV8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase g subunit family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion http://togogenome.org/gene/9483:PGP ^@ http://purl.uniprot.org/uniprot/F7GP32 ^@ Cofactor|||Similarity ^@ Belongs to the HAD-like hydrolase superfamily.|||Divalent metal ions. Mg(2+) is the most effective. http://togogenome.org/gene/9483:DDB2 ^@ http://purl.uniprot.org/uniprot/F6XWE0|||http://purl.uniprot.org/uniprot/F6XWJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat DDB2/WDR76 family.|||Nucleus http://togogenome.org/gene/9483:DUSP10 ^@ http://purl.uniprot.org/uniprot/F7HX42 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9483:AVP ^@ http://purl.uniprot.org/uniprot/A0A8I3WIQ5 ^@ Similarity ^@ Belongs to the vasopressin/oxytocin family. http://togogenome.org/gene/9483:DHPS ^@ http://purl.uniprot.org/uniprot/F7FZK0 ^@ Similarity ^@ Belongs to the deoxyhypusine synthase family. http://togogenome.org/gene/9483:ABCG2 ^@ http://purl.uniprot.org/uniprot/U3EDG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/9483:DEGS2 ^@ http://purl.uniprot.org/uniprot/U3CEP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:KATNAL1 ^@ http://purl.uniprot.org/uniprot/U3BZV3 ^@ Activity Regulation|||Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.|||Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.|||Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.|||Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.|||Cytoplasm|||Interacts with KATNB1 and KATNBL1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Midbody|||Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.|||Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.|||The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.|||Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.|||centrosome|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/9483:MAL2 ^@ http://purl.uniprot.org/uniprot/A0A2R8MA05 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:LBX1 ^@ http://purl.uniprot.org/uniprot/F7FXK8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:TBX19 ^@ http://purl.uniprot.org/uniprot/F6VM56 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9483:MAGI3 ^@ http://purl.uniprot.org/uniprot/F7AVA2|||http://purl.uniprot.org/uniprot/U3FRJ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:SEC61G ^@ http://purl.uniprot.org/uniprot/A0A5F4WGJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecE/SEC61-gamma family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:ITGB3BP ^@ http://purl.uniprot.org/uniprot/U3BB95 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Transcription coregulator that can have both coactivator and corepressor functions.|||centromere|||kinetochore http://togogenome.org/gene/9483:SMPD1 ^@ http://purl.uniprot.org/uniprot/F7IQZ3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acid sphingomyelinase family.|||Binds 2 Zn(2+) ions per subunit.|||Converts sphingomyelin to ceramide.|||Secreted http://togogenome.org/gene/9483:NANOG ^@ http://purl.uniprot.org/uniprot/F7I8S8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:FAM133B ^@ http://purl.uniprot.org/uniprot/U3DPH9 ^@ Similarity ^@ Belongs to the FAM133 family. http://togogenome.org/gene/9483:LHX3 ^@ http://purl.uniprot.org/uniprot/A0A2R8MDX0|||http://purl.uniprot.org/uniprot/F6XKK4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:FOXL3 ^@ http://purl.uniprot.org/uniprot/A0A2R8M6B4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:MAP6 ^@ http://purl.uniprot.org/uniprot/F6UHV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STOP family.|||cytoskeleton http://togogenome.org/gene/9483:KNG1 ^@ http://purl.uniprot.org/uniprot/A0A8I4A4X8 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/9483:DUSP2 ^@ http://purl.uniprot.org/uniprot/U3EPC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/9483:MELK ^@ http://purl.uniprot.org/uniprot/F6SKD5|||http://purl.uniprot.org/uniprot/F7HM37 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. http://togogenome.org/gene/9483:AASS ^@ http://purl.uniprot.org/uniprot/F7I9Y6 ^@ Similarity ^@ In the C-terminal section; belongs to the saccharopine dehydrogenase family.|||In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/9483:DHRS7C ^@ http://purl.uniprot.org/uniprot/F7II92|||http://purl.uniprot.org/uniprot/U3FD97 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9483:HADHA ^@ http://purl.uniprot.org/uniprot/F7HUX7 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9483:VEZT ^@ http://purl.uniprot.org/uniprot/U3BY21|||http://purl.uniprot.org/uniprot/U3DX34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vezatin family.|||Cell membrane|||Membrane|||Nucleus|||adherens junction http://togogenome.org/gene/9483:TMEM198 ^@ http://purl.uniprot.org/uniprot/B0KWJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM198 family.|||Membrane http://togogenome.org/gene/9483:CRYZ ^@ http://purl.uniprot.org/uniprot/F7GNH5 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/9483:TRIQK ^@ http://purl.uniprot.org/uniprot/F7GTE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIQK family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:S100A8 ^@ http://purl.uniprot.org/uniprot/A0A8J8YBA8 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9483:RNASEH1 ^@ http://purl.uniprot.org/uniprot/F7H3J8|||http://purl.uniprot.org/uniprot/U3CQT2|||http://purl.uniprot.org/uniprot/U3FRY9 ^@ Function|||Similarity ^@ Belongs to the RNase H family.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. http://togogenome.org/gene/9483:FOXJ3 ^@ http://purl.uniprot.org/uniprot/U3BLV8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:POLR1D ^@ http://purl.uniprot.org/uniprot/F7DLJ3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. http://togogenome.org/gene/9483:CTSC ^@ http://purl.uniprot.org/uniprot/U3CIA8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C1 family.|||Lysosome|||Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains. http://togogenome.org/gene/9483:HPS6 ^@ http://purl.uniprot.org/uniprot/F7G6I5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6. Interacts with HPS5 and HPS3. Interacts with biogenesis of lysosome-related organelles complex-1 (BLOC1). Interacts with AP-3 complex.|||May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.|||Microsome membrane http://togogenome.org/gene/9483:TGFBI ^@ http://purl.uniprot.org/uniprot/U3D692 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9483:PRC1 ^@ http://purl.uniprot.org/uniprot/F7IEP8|||http://purl.uniprot.org/uniprot/U3F2X1 ^@ Similarity ^@ Belongs to the MAP65/ASE1 family. http://togogenome.org/gene/9483:GLOD4 ^@ http://purl.uniprot.org/uniprot/U3ATV7 ^@ Similarity ^@ Belongs to the glyoxalase I family. http://togogenome.org/gene/9483:NONO ^@ http://purl.uniprot.org/uniprot/U3F519 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/9483:CCT6A ^@ http://purl.uniprot.org/uniprot/F7IN44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9483:BRINP2 ^@ http://purl.uniprot.org/uniprot/F7E830 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/9483:MRPS16 ^@ http://purl.uniprot.org/uniprot/F7GYM4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/9483:TMEM115 ^@ http://purl.uniprot.org/uniprot/F7DM07 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:AMER2 ^@ http://purl.uniprot.org/uniprot/F7H2Q2 ^@ Similarity ^@ Belongs to the Amer family. http://togogenome.org/gene/9483:TACR2 ^@ http://purl.uniprot.org/uniprot/A0A2R8MLH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:SVBP ^@ http://purl.uniprot.org/uniprot/A0A8I3W3E0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SVBP family.|||Secreted|||cytoskeleton http://togogenome.org/gene/9483:SLC44A3 ^@ http://purl.uniprot.org/uniprot/U3D2I8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/9483:TMOD3 ^@ http://purl.uniprot.org/uniprot/F7BX02 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9483:SCUBE3 ^@ http://purl.uniprot.org/uniprot/A0A5F4WJ90 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9483:CBL ^@ http://purl.uniprot.org/uniprot/F7CSE3 ^@ Domain|||Function ^@ E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.|||The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain. http://togogenome.org/gene/9483:DCLRE1A ^@ http://purl.uniprot.org/uniprot/U3DB16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/9483:HOXC12 ^@ http://purl.uniprot.org/uniprot/F7IAK9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:LOC100401239 ^@ http://purl.uniprot.org/uniprot/A0A2R8MVQ0 ^@ Similarity ^@ In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.|||In the N-terminal section; belongs to the ubiquitin family. http://togogenome.org/gene/9483:TMEM41B ^@ http://purl.uniprot.org/uniprot/F6U6D9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM41 family.|||Membrane http://togogenome.org/gene/9483:PCNX4 ^@ http://purl.uniprot.org/uniprot/F7HUM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pecanex family.|||Membrane http://togogenome.org/gene/9483:MFF ^@ http://purl.uniprot.org/uniprot/A0A8I3WRP1|||http://purl.uniprot.org/uniprot/A0A8I3X5X3|||http://purl.uniprot.org/uniprot/F7BAA2|||http://purl.uniprot.org/uniprot/F7I7Q9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Tango11 family.|||Membrane|||Mitochondrion outer membrane|||Peroxisome|||Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.|||synaptic vesicle http://togogenome.org/gene/9483:NSUN5 ^@ http://purl.uniprot.org/uniprot/U3FK60 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/9483:AMER3 ^@ http://purl.uniprot.org/uniprot/U3ERK3 ^@ Similarity ^@ Belongs to the Amer family. http://togogenome.org/gene/9483:PAN3 ^@ http://purl.uniprot.org/uniprot/F7FBS4|||http://purl.uniprot.org/uniprot/U3BH95|||http://purl.uniprot.org/uniprot/U3F559 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. PAN3 family.|||Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.|||Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PABPC1 (via PABC domain), conferring substrate specificity of the enzyme complex. Interacts with the GW182 family proteins TNRC6A, TNRC6B and TNRC6C.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||P-body|||Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.|||The N-terminal zinc finger binds to poly(A) RNA.|||The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2. http://togogenome.org/gene/9483:LOC100402270 ^@ http://purl.uniprot.org/uniprot/F7HA83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:ME3 ^@ http://purl.uniprot.org/uniprot/A0A2R8MMW3|||http://purl.uniprot.org/uniprot/A0A2R8MQ64|||http://purl.uniprot.org/uniprot/A0A5F4WDJ1 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/9483:SLC35F6 ^@ http://purl.uniprot.org/uniprot/U3DSE7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SLC35F solute transporter family.|||Interacts with SLC25A5.|||May play a role as a nucleotide-sugar transporter.|||Membrane|||Mitochondrion http://togogenome.org/gene/9483:TNFSF8 ^@ http://purl.uniprot.org/uniprot/F7HVK4 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9483:BEST1 ^@ http://purl.uniprot.org/uniprot/F7IFS0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms calcium-sensitive chloride channels. Permeable to bicarbonate.|||Membrane http://togogenome.org/gene/9483:P2RX3 ^@ http://purl.uniprot.org/uniprot/F6VP75 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9483:CDCA7 ^@ http://purl.uniprot.org/uniprot/F7IND7|||http://purl.uniprot.org/uniprot/U3BCY5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9483:RTCB ^@ http://purl.uniprot.org/uniprot/U3CZR4 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Catalytic component of the tRNA-splicing ligase complex.|||Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.|||Cytoplasm|||Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP. http://togogenome.org/gene/9483:AASDH ^@ http://purl.uniprot.org/uniprot/A0A8I3X0Z9|||http://purl.uniprot.org/uniprot/F6QFB5 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9483:NDUFB7 ^@ http://purl.uniprot.org/uniprot/F7HN05 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB7 subunit family.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/9483:AP2M1 ^@ http://purl.uniprot.org/uniprot/F7F7R2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cell membrane|||Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.|||coated pit http://togogenome.org/gene/9483:ATP6V1C1 ^@ http://purl.uniprot.org/uniprot/F7INY1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits. http://togogenome.org/gene/9483:CDK2AP2 ^@ http://purl.uniprot.org/uniprot/F6ZYF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDK2AP family.|||Nucleus http://togogenome.org/gene/9483:CRTC3 ^@ http://purl.uniprot.org/uniprot/F7D1B5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TORC family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:YES1 ^@ http://purl.uniprot.org/uniprot/U3DF65 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9483:PPM1L ^@ http://purl.uniprot.org/uniprot/U3BGK7 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9483:HNRNPDL ^@ http://purl.uniprot.org/uniprot/F6UJD1|||http://purl.uniprot.org/uniprot/U3CE03 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9483:IL19 ^@ http://purl.uniprot.org/uniprot/A0A2R8MR56 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/9483:PPP1CB ^@ http://purl.uniprot.org/uniprot/U3DD84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family. PP-1 subfamily.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9483:ZNF287 ^@ http://purl.uniprot.org/uniprot/A0A8I3WZE2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:RAB39B ^@ http://purl.uniprot.org/uniprot/B0KWV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:SLC39A11 ^@ http://purl.uniprot.org/uniprot/A0A5K1V085|||http://purl.uniprot.org/uniprot/F6WNH0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:IL10 ^@ http://purl.uniprot.org/uniprot/A0A7R8GUT3|||http://purl.uniprot.org/uniprot/Q0Z972 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-10 family.|||Homodimer. Interacts with IL10RA and IL10RB.|||Immune regulatory cytokine.|||Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).|||Secreted http://togogenome.org/gene/9483:CACNG1 ^@ http://purl.uniprot.org/uniprot/F6QLS5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.|||sarcolemma http://togogenome.org/gene/9483:S100PBP ^@ http://purl.uniprot.org/uniprot/U3DXQ9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:NIT2 ^@ http://purl.uniprot.org/uniprot/U3EDE1 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. http://togogenome.org/gene/9483:DACT1 ^@ http://purl.uniprot.org/uniprot/U3B9U5|||http://purl.uniprot.org/uniprot/U3BSZ1 ^@ Similarity ^@ Belongs to the dapper family. http://togogenome.org/gene/9483:HSPB8 ^@ http://purl.uniprot.org/uniprot/F7ALK2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Cytoplasm|||Displays temperature-dependent chaperone activity.|||Nucleus http://togogenome.org/gene/9483:SATB2 ^@ http://purl.uniprot.org/uniprot/U3CZ49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/9483:IRF5 ^@ http://purl.uniprot.org/uniprot/F6RYK3|||http://purl.uniprot.org/uniprot/F6SJR4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:PC ^@ http://purl.uniprot.org/uniprot/U3D6Y3 ^@ Function ^@ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. http://togogenome.org/gene/9483:FBP1 ^@ http://purl.uniprot.org/uniprot/F7DT76 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/9483:RGS5 ^@ http://purl.uniprot.org/uniprot/F6TDR7 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. http://togogenome.org/gene/9483:KIN ^@ http://purl.uniprot.org/uniprot/F7CBX1|||http://purl.uniprot.org/uniprot/U3CW28 ^@ Similarity ^@ Belongs to the KIN17 family. http://togogenome.org/gene/9483:USP4 ^@ http://purl.uniprot.org/uniprot/F6TSE3|||http://purl.uniprot.org/uniprot/F6TSU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Cytoplasm|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Nucleus http://togogenome.org/gene/9483:PUF60 ^@ http://purl.uniprot.org/uniprot/A0A8J8XV49|||http://purl.uniprot.org/uniprot/U3CWN2|||http://purl.uniprot.org/uniprot/U3DDS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM half pint family.|||Nucleus http://togogenome.org/gene/9483:LOC108587699 ^@ http://purl.uniprot.org/uniprot/B0VX89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:TRIM56 ^@ http://purl.uniprot.org/uniprot/F7I5G2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm http://togogenome.org/gene/9483:UBAC2 ^@ http://purl.uniprot.org/uniprot/F7FK29 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:TENT5A ^@ http://purl.uniprot.org/uniprot/A0A2R8MMQ7 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/9483:PIK3C2A ^@ http://purl.uniprot.org/uniprot/U3E5M4 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9483:SNTB1 ^@ http://purl.uniprot.org/uniprot/U3BJ13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntrophin family.|||Cell junction|||cytoskeleton http://togogenome.org/gene/9483:LEPROTL1 ^@ http://purl.uniprot.org/uniprot/U3FN14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OB-RGRP/VPS55 family.|||Membrane http://togogenome.org/gene/9483:TMEM107 ^@ http://purl.uniprot.org/uniprot/U3DQS6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:NGDN ^@ http://purl.uniprot.org/uniprot/F7I2L1 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9483:DCN ^@ http://purl.uniprot.org/uniprot/F7HDP7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.|||May affect the rate of fibrils formation.|||extracellular matrix http://togogenome.org/gene/9483:LOC103790239 ^@ http://purl.uniprot.org/uniprot/A0A8I3WWI3 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9483:ATP5F1C ^@ http://purl.uniprot.org/uniprot/F7I4L8|||http://purl.uniprot.org/uniprot/F7I4N1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase gamma chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. http://togogenome.org/gene/9483:LOC100411291 ^@ http://purl.uniprot.org/uniprot/A0A8I3WFP9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/9483:COX6B2 ^@ http://purl.uniprot.org/uniprot/A0A8I3WWF5 ^@ Function|||Similarity ^@ Belongs to the cytochrome c oxidase subunit 6B.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. http://togogenome.org/gene/9483:LOC100385614 ^@ http://purl.uniprot.org/uniprot/F7HKW4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/9483:EHD1 ^@ http://purl.uniprot.org/uniprot/B0KWK7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/9483:FABP12 ^@ http://purl.uniprot.org/uniprot/F6SDK8 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9483:CPSF6 ^@ http://purl.uniprot.org/uniprot/F7GPL3|||http://purl.uniprot.org/uniprot/F7GUT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM CPSF6/7 family.|||Nucleus http://togogenome.org/gene/9483:MRPL41 ^@ http://purl.uniprot.org/uniprot/U3CV55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL41 family.|||Mitochondrion http://togogenome.org/gene/9483:ANAPC5 ^@ http://purl.uniprot.org/uniprot/F7IQN6|||http://purl.uniprot.org/uniprot/U3FF52 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APC5 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|||spindle http://togogenome.org/gene/9483:SLC2A4 ^@ http://purl.uniprot.org/uniprot/U3C130 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Endomembrane system|||Membrane|||perinuclear region http://togogenome.org/gene/9483:INTS3 ^@ http://purl.uniprot.org/uniprot/F7FD65 ^@ Similarity ^@ Belongs to the Integrator subunit 3 family. http://togogenome.org/gene/9483:SBF2 ^@ http://purl.uniprot.org/uniprot/A0A8I4A096|||http://purl.uniprot.org/uniprot/U3EI45 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9483:ACAP1 ^@ http://purl.uniprot.org/uniprot/F6VZY8 ^@ Activity Regulation|||Domain|||Function|||Subcellular Location Annotation ^@ Endosome membrane|||GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.|||GTPase-activating protein for the ADP ribosylation factor family.|||PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.|||The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions. http://togogenome.org/gene/9483:MBOAT7 ^@ http://purl.uniprot.org/uniprot/F6XQJ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:SHOX2 ^@ http://purl.uniprot.org/uniprot/A0A8I3WT61 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:PPIL3 ^@ http://purl.uniprot.org/uniprot/F7IMM5 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9483:PEX19 ^@ http://purl.uniprot.org/uniprot/F7HYX7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxin-19 family.|||Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.|||Membrane|||Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.|||Peroxisome membrane http://togogenome.org/gene/9483:GUF1 ^@ http://purl.uniprot.org/uniprot/F7IQ52 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding elongation factor family. LepA subfamily.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Mitochondrion inner membrane|||Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. http://togogenome.org/gene/9483:ST3GAL5 ^@ http://purl.uniprot.org/uniprot/F7GY79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9483:RPS25 ^@ http://purl.uniprot.org/uniprot/F7AIV0 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS25 family.|||Component of the small ribosomal subunit. http://togogenome.org/gene/9483:EMC9 ^@ http://purl.uniprot.org/uniprot/F6ZHH5 ^@ Similarity ^@ Belongs to the EMC8/EMC9 family. http://togogenome.org/gene/9483:E2F3 ^@ http://purl.uniprot.org/uniprot/F7HDR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9483:KRT20 ^@ http://purl.uniprot.org/uniprot/F7BJQ3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9483:PMS1 ^@ http://purl.uniprot.org/uniprot/F7F052 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/9483:MED30 ^@ http://purl.uniprot.org/uniprot/U3E850 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 30 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/9483:PROK2 ^@ http://purl.uniprot.org/uniprot/A0A2R8N9W0|||http://purl.uniprot.org/uniprot/A0A8I3WA50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AVIT (prokineticin) family.|||Secreted http://togogenome.org/gene/9483:LOC100387174 ^@ http://purl.uniprot.org/uniprot/B0CMB1 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9483:SLC13A5 ^@ http://purl.uniprot.org/uniprot/A0A8J8XV24|||http://purl.uniprot.org/uniprot/A0A8J8YKQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/9483:LOC100411784 ^@ http://purl.uniprot.org/uniprot/A0A8I3X6E2 ^@ Similarity ^@ Belongs to the histone H2B family. http://togogenome.org/gene/9483:RTCA ^@ http://purl.uniprot.org/uniprot/A0A8I3X949|||http://purl.uniprot.org/uniprot/F7H6I6 ^@ Function|||Similarity ^@ Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.|||Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. http://togogenome.org/gene/9483:EPN2 ^@ http://purl.uniprot.org/uniprot/U3FWH5 ^@ Similarity ^@ Belongs to the epsin family. http://togogenome.org/gene/9483:CHSY1 ^@ http://purl.uniprot.org/uniprot/F7HY89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9483:CYB5R3 ^@ http://purl.uniprot.org/uniprot/U3C856 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/9483:CEP57L1 ^@ http://purl.uniprot.org/uniprot/U3C9K5 ^@ Similarity ^@ Belongs to the translokin family. http://togogenome.org/gene/9483:HMGCLL1 ^@ http://purl.uniprot.org/uniprot/F7H8Z9 ^@ Similarity ^@ Belongs to the HMG-CoA lyase family. http://togogenome.org/gene/9483:WNT10A ^@ http://purl.uniprot.org/uniprot/F7GQE8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9483:OGDH ^@ http://purl.uniprot.org/uniprot/F6WZI4|||http://purl.uniprot.org/uniprot/F6XLN9|||http://purl.uniprot.org/uniprot/U3DCU9|||http://purl.uniprot.org/uniprot/U3FNY3 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/9483:USP37 ^@ http://purl.uniprot.org/uniprot/F7ES35 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9483:CCDC65 ^@ http://purl.uniprot.org/uniprot/F7IT01 ^@ Subcellular Location Annotation ^@ flagellum axoneme http://togogenome.org/gene/9483:VPS4A ^@ http://purl.uniprot.org/uniprot/U3DRT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9483:TM2D3 ^@ http://purl.uniprot.org/uniprot/U3D2D9|||http://purl.uniprot.org/uniprot/U3EHM1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:ITPRIPL2 ^@ http://purl.uniprot.org/uniprot/U3CUS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITPRIP family.|||Membrane http://togogenome.org/gene/9483:CYP3A4 ^@ http://purl.uniprot.org/uniprot/O18993 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane|||P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens. http://togogenome.org/gene/9483:PSMD1 ^@ http://purl.uniprot.org/uniprot/U3ENA8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S1 family.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. http://togogenome.org/gene/9483:SLC43A1 ^@ http://purl.uniprot.org/uniprot/U3C3I7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:PPIF ^@ http://purl.uniprot.org/uniprot/A0A5F4WM42 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9483:XPC ^@ http://purl.uniprot.org/uniprot/U3DIM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPC family.|||Nucleus http://togogenome.org/gene/9483:DPH5 ^@ http://purl.uniprot.org/uniprot/F7ERT2 ^@ Function|||Similarity ^@ Belongs to the diphthine synthase family.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/9483:KCNC2 ^@ http://purl.uniprot.org/uniprot/A0A5F4W2U6|||http://purl.uniprot.org/uniprot/A0A8I4A4L2|||http://purl.uniprot.org/uniprot/F7HVC4|||http://purl.uniprot.org/uniprot/F7HVE1|||http://purl.uniprot.org/uniprot/F7HVE2|||http://purl.uniprot.org/uniprot/F7HVE3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:RGR ^@ http://purl.uniprot.org/uniprot/U3CHN1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:CTNND2 ^@ http://purl.uniprot.org/uniprot/A0A8I3VZA1 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/9483:OR1L3 ^@ http://purl.uniprot.org/uniprot/F7B0Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:KLRK1 ^@ http://purl.uniprot.org/uniprot/A4GHD0|||http://purl.uniprot.org/uniprot/A4GHD1 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9483:RETREG3 ^@ http://purl.uniprot.org/uniprot/F7HNU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RETREG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:C8B ^@ http://purl.uniprot.org/uniprot/F7IA58 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9483:CYP2R1 ^@ http://purl.uniprot.org/uniprot/F7I9Q1 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9483:ATP6AP2 ^@ http://purl.uniprot.org/uniprot/F7GIK4 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Lysosome membrane|||Membrane|||autophagosome membrane|||clathrin-coated vesicle membrane|||dendritic spine membrane|||synaptic vesicle membrane http://togogenome.org/gene/9483:KRT19 ^@ http://purl.uniprot.org/uniprot/U3E6V8 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9483:PRKACB ^@ http://purl.uniprot.org/uniprot/A0A2R8MZJ8|||http://purl.uniprot.org/uniprot/A0A8I3WBJ8|||http://purl.uniprot.org/uniprot/F7FX16|||http://purl.uniprot.org/uniprot/F7IA24 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/9483:CPLX4 ^@ http://purl.uniprot.org/uniprot/A0A5F4VUD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9483:MZT1 ^@ http://purl.uniprot.org/uniprot/F7F1E1 ^@ Function|||Similarity ^@ Belongs to the MOZART1 family.|||Required for gamma-tubulin complex recruitment to the centrosome. http://togogenome.org/gene/9483:EXTL3 ^@ http://purl.uniprot.org/uniprot/A0A2R8PFB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:NDEL1 ^@ http://purl.uniprot.org/uniprot/A0A8I3WI93|||http://purl.uniprot.org/uniprot/U3AVW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nudE family.|||centrosome|||kinetochore|||spindle http://togogenome.org/gene/9483:ATP8A1 ^@ http://purl.uniprot.org/uniprot/F7H2Q6|||http://purl.uniprot.org/uniprot/U3CLS5|||http://purl.uniprot.org/uniprot/U3ECZ6|||http://purl.uniprot.org/uniprot/U3EDG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9483:APH1A ^@ http://purl.uniprot.org/uniprot/U3DJW2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the APH-1 family.|||Component of the gamma-secretase complex.|||Membrane|||Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. http://togogenome.org/gene/9483:LYSET ^@ http://purl.uniprot.org/uniprot/A0A8I3WHR4|||http://purl.uniprot.org/uniprot/F6VKZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LYSET family.|||Membrane http://togogenome.org/gene/9483:SLC25A46 ^@ http://purl.uniprot.org/uniprot/F7I9N7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9483:SLC25A11 ^@ http://purl.uniprot.org/uniprot/F6RKX7|||http://purl.uniprot.org/uniprot/F7EGM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9483:ARSG ^@ http://purl.uniprot.org/uniprot/F7G1L1 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9483:TMEM170A ^@ http://purl.uniprot.org/uniprot/F7ITE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM170 family.|||Membrane http://togogenome.org/gene/9483:TMEM151A ^@ http://purl.uniprot.org/uniprot/F7IQK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM151 family.|||Membrane http://togogenome.org/gene/9483:LOC100386428 ^@ http://purl.uniprot.org/uniprot/A0A5F4WEM7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/9483:PFDN4 ^@ http://purl.uniprot.org/uniprot/A0A2R8MGV4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/9483:IRX3 ^@ http://purl.uniprot.org/uniprot/F7INF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/IRO homeobox family.|||Nucleus http://togogenome.org/gene/9483:LVRN ^@ http://purl.uniprot.org/uniprot/F6XCN7 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9483:NDUFS4 ^@ http://purl.uniprot.org/uniprot/U3CCC1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS4 subunit family.|||Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:DDX3X ^@ http://purl.uniprot.org/uniprot/F7IPC4|||http://purl.uniprot.org/uniprot/U3BPE2|||http://purl.uniprot.org/uniprot/U3F245 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9483:MCRIP1 ^@ http://purl.uniprot.org/uniprot/H9KVX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCRIP family.|||Nucleus|||Stress granule http://togogenome.org/gene/9483:MSRB2 ^@ http://purl.uniprot.org/uniprot/U3FFK9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Binds 1 zinc ion per subunit.|||Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. http://togogenome.org/gene/9483:MYO16 ^@ http://purl.uniprot.org/uniprot/F7ISV5 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9483:TEX261 ^@ http://purl.uniprot.org/uniprot/F7GTP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SVP26 family.|||Membrane http://togogenome.org/gene/9483:BROX ^@ http://purl.uniprot.org/uniprot/U3F6X8 ^@ Similarity ^@ Belongs to the BROX family. http://togogenome.org/gene/9483:PGAM2 ^@ http://purl.uniprot.org/uniprot/F7HXH1 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/9483:TPRKB ^@ http://purl.uniprot.org/uniprot/U3CI83 ^@ Similarity ^@ Belongs to the CGI121/TPRKB family. http://togogenome.org/gene/9483:FGF22 ^@ http://purl.uniprot.org/uniprot/F7G046 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9483:UTP25 ^@ http://purl.uniprot.org/uniprot/U3EH16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP25 family.|||nucleolus http://togogenome.org/gene/9483:IFI30 ^@ http://purl.uniprot.org/uniprot/U3EAL7 ^@ Similarity|||Subunit ^@ Belongs to the GILT family.|||Dimer; disulfide-linked. http://togogenome.org/gene/9483:CDKN1B ^@ http://purl.uniprot.org/uniprot/F7HH57 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/9483:RPIA ^@ http://purl.uniprot.org/uniprot/F7EL42 ^@ Similarity ^@ Belongs to the ribose 5-phosphate isomerase family. http://togogenome.org/gene/9483:RPN2 ^@ http://purl.uniprot.org/uniprot/F7IJ88|||http://purl.uniprot.org/uniprot/U3CRS5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SWP1 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/9483:TLR1 ^@ http://purl.uniprot.org/uniprot/F6X7G7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane|||Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. http://togogenome.org/gene/9483:NR4A1 ^@ http://purl.uniprot.org/uniprot/U3E1S7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR4 subfamily.|||In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7.|||Nucleus|||cytosol http://togogenome.org/gene/9483:FAM151B ^@ http://purl.uniprot.org/uniprot/F7GXZ1 ^@ Similarity ^@ Belongs to the FAM151 family. http://togogenome.org/gene/9483:MMP23B ^@ http://purl.uniprot.org/uniprot/F7GLA7 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:NQO1 ^@ http://purl.uniprot.org/uniprot/A0A2R8MT21|||http://purl.uniprot.org/uniprot/F7EKA7 ^@ Similarity ^@ Belongs to the NAD(P)H dehydrogenase (quinone) family. http://togogenome.org/gene/9483:HPDL ^@ http://purl.uniprot.org/uniprot/F7DDE2 ^@ Cofactor|||Similarity ^@ Belongs to the 4HPPD family.|||Binds 1 Fe cation per subunit. http://togogenome.org/gene/9483:GNAI1 ^@ http://purl.uniprot.org/uniprot/F7IEH0 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9483:LOC100406098 ^@ http://purl.uniprot.org/uniprot/A0A7R8C3F1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9483:MLLT3 ^@ http://purl.uniprot.org/uniprot/A0A5F4VXF6|||http://purl.uniprot.org/uniprot/F7C404 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:IRF7 ^@ http://purl.uniprot.org/uniprot/U3BP84 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:ZC3H15 ^@ http://purl.uniprot.org/uniprot/U3DXN7 ^@ Similarity ^@ Belongs to the ZC3H15/TMA46 family. http://togogenome.org/gene/9483:GC ^@ http://purl.uniprot.org/uniprot/F7IP47 ^@ Function|||Subcellular Location Annotation ^@ Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.|||Secreted http://togogenome.org/gene/9483:CCKAR ^@ http://purl.uniprot.org/uniprot/A0A8I3XB38 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9483:CACNB3 ^@ http://purl.uniprot.org/uniprot/A0A2R8MDP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||Cytoplasm http://togogenome.org/gene/9483:ARPP19 ^@ http://purl.uniprot.org/uniprot/F7AF76 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endosulfine family.|||Cytoplasm|||Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. http://togogenome.org/gene/9483:CORO7 ^@ http://purl.uniprot.org/uniprot/U3CIU7 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/9483:IL23A ^@ http://purl.uniprot.org/uniprot/A0A2R8N533 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-6 superfamily.|||Secreted http://togogenome.org/gene/9483:AMPD1 ^@ http://purl.uniprot.org/uniprot/F7I5U7|||http://purl.uniprot.org/uniprot/F7I851 ^@ Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.|||Homotetramer. http://togogenome.org/gene/9483:BORCS8 ^@ http://purl.uniprot.org/uniprot/F6QVS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS8 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9483:PLSCR1 ^@ http://purl.uniprot.org/uniprot/U3APV7 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/9483:MT2A ^@ http://purl.uniprot.org/uniprot/A0A8I3WDW9 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9483:NEMP2 ^@ http://purl.uniprot.org/uniprot/F7IFN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NEMP family.|||Nucleus inner membrane http://togogenome.org/gene/9483:RPL26 ^@ http://purl.uniprot.org/uniprot/F7HQ77 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/9483:OR52E2 ^@ http://purl.uniprot.org/uniprot/B0VXA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:MAPRE2 ^@ http://purl.uniprot.org/uniprot/A0A5F4W6S5|||http://purl.uniprot.org/uniprot/F7EAS4|||http://purl.uniprot.org/uniprot/F7EW78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||cytoskeleton http://togogenome.org/gene/9483:ZRANB1 ^@ http://purl.uniprot.org/uniprot/F7III3|||http://purl.uniprot.org/uniprot/U3FPZ0 ^@ Similarity ^@ Belongs to the peptidase C64 family. http://togogenome.org/gene/9483:PDCL ^@ http://purl.uniprot.org/uniprot/F7BIF8 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9483:CNIH4 ^@ http://purl.uniprot.org/uniprot/F7IBF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/9483:B4GALT6 ^@ http://purl.uniprot.org/uniprot/F7IDV1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9483:ACKR1 ^@ http://purl.uniprot.org/uniprot/E0XJE0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.|||Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.|||Early endosome|||Membrane|||Recycling endosome http://togogenome.org/gene/9483:SEPTIN7 ^@ http://purl.uniprot.org/uniprot/F7HWN8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cleavage furrow|||Filament-forming cytoskeletal GTPase.|||Midbody|||Septins polymerize into heterooligomeric protein complexes that form filaments.|||cilium axoneme|||flagellum|||kinetochore|||spindle http://togogenome.org/gene/9483:RSBN1 ^@ http://purl.uniprot.org/uniprot/F7HUK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the round spermatid basic protein 1 family.|||Nucleus http://togogenome.org/gene/9483:MSX2 ^@ http://purl.uniprot.org/uniprot/F7I6A5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:ZDHHC21 ^@ http://purl.uniprot.org/uniprot/F7HUB7 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9483:PHB1 ^@ http://purl.uniprot.org/uniprot/F7AH92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Cell membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9483:SLC25A38 ^@ http://purl.uniprot.org/uniprot/A0A5F4VR98 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.|||Membrane|||Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.|||Mitochondrion inner membrane|||Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis. http://togogenome.org/gene/9483:FAM114A2 ^@ http://purl.uniprot.org/uniprot/U3FMF4 ^@ Similarity ^@ Belongs to the FAM114 family. http://togogenome.org/gene/9483:COQ7 ^@ http://purl.uniprot.org/uniprot/F6XXM7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ7 family.|||Binds 2 iron ions per subunit.|||Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:FAR1 ^@ http://purl.uniprot.org/uniprot/U3E399 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acyl-CoA reductase family.|||Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.|||Peroxisome membrane http://togogenome.org/gene/9483:ATOSA ^@ http://purl.uniprot.org/uniprot/U3DKZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATOS family.|||Nucleus http://togogenome.org/gene/9483:PRPF3 ^@ http://purl.uniprot.org/uniprot/U3DW67 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). http://togogenome.org/gene/9483:LOC100398547 ^@ http://purl.uniprot.org/uniprot/A0A5F4VWY2 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9483:PRL ^@ http://purl.uniprot.org/uniprot/F7ICU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Secreted http://togogenome.org/gene/9483:PGA ^@ http://purl.uniprot.org/uniprot/Q9N2D4 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Inhibited by pepstatin.|||Secreted|||Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. http://togogenome.org/gene/9483:DEDD ^@ http://purl.uniprot.org/uniprot/F7GWR4 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9483:LOC100410987 ^@ http://purl.uniprot.org/uniprot/U3FT46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX15/CtaA family.|||Membrane http://togogenome.org/gene/9483:AJUBA ^@ http://purl.uniprot.org/uniprot/F7GZN5 ^@ Similarity ^@ Belongs to the zyxin/ajuba family. http://togogenome.org/gene/9483:SMPX ^@ http://purl.uniprot.org/uniprot/F7DME5 ^@ Function|||Similarity ^@ Belongs to the SMPX family.|||Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair. http://togogenome.org/gene/9483:CD44 ^@ http://purl.uniprot.org/uniprot/F6PQY5|||http://purl.uniprot.org/uniprot/F7FML0|||http://purl.uniprot.org/uniprot/F7ICN5|||http://purl.uniprot.org/uniprot/U3DNN5|||http://purl.uniprot.org/uniprot/U3FDP6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||microvillus http://togogenome.org/gene/9483:EPHB4 ^@ http://purl.uniprot.org/uniprot/U3BYP0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:ELP2 ^@ http://purl.uniprot.org/uniprot/U3BWB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat ELP2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:LOC100392617 ^@ http://purl.uniprot.org/uniprot/U3DF39 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/9483:GOT1 ^@ http://purl.uniprot.org/uniprot/F7GSG3 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/9483:SEC23B ^@ http://purl.uniprot.org/uniprot/F7IMB2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9483:SCGN ^@ http://purl.uniprot.org/uniprot/F6XL01 ^@ Subcellular Location Annotation ^@ secretory vesicle membrane http://togogenome.org/gene/9483:GPR17 ^@ http://purl.uniprot.org/uniprot/A0A5F4VVE1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9483:TNFRSF10B ^@ http://purl.uniprot.org/uniprot/F7CE02 ^@ Caution|||Function ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. http://togogenome.org/gene/9483:P2RX7 ^@ http://purl.uniprot.org/uniprot/F7HRX1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P2X receptor family.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9483:SNU13 ^@ http://purl.uniprot.org/uniprot/H9KVU2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/9483:BCO1 ^@ http://purl.uniprot.org/uniprot/A0A8I3WVM0 ^@ Cofactor|||Similarity ^@ Belongs to the carotenoid oxygenase family.|||Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/9483:FGF3 ^@ http://purl.uniprot.org/uniprot/F7HVK7 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9483:PPP1R3C ^@ http://purl.uniprot.org/uniprot/F7GL21 ^@ Domain|||Function|||Subunit ^@ Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.|||Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.|||The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase. http://togogenome.org/gene/9483:INTS2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XMZ6 ^@ Similarity ^@ Belongs to the Integrator subunit 2 family. http://togogenome.org/gene/9483:EPAS1 ^@ http://purl.uniprot.org/uniprot/U3DUV3 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/9483:LBH ^@ http://purl.uniprot.org/uniprot/F7HVN1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LBH family.|||Cytoplasm|||Nucleus|||Transcriptional activator. http://togogenome.org/gene/9483:COQ10B ^@ http://purl.uniprot.org/uniprot/A0A2R8MIC0|||http://purl.uniprot.org/uniprot/F6PJ77 ^@ Function|||Similarity|||Subunit ^@ Belongs to the COQ10 family.|||Interacts with coenzyme Q.|||Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. http://togogenome.org/gene/9483:LOC100411216 ^@ http://purl.uniprot.org/uniprot/A0A5F4WLF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:MICOS10 ^@ http://purl.uniprot.org/uniprot/A0A8I3WIY8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic10 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:GABRG2 ^@ http://purl.uniprot.org/uniprot/F6WUL1|||http://purl.uniprot.org/uniprot/F6XG46 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9483:FOXN3 ^@ http://purl.uniprot.org/uniprot/F7HBY1|||http://purl.uniprot.org/uniprot/F7HH72|||http://purl.uniprot.org/uniprot/U3AX94 ^@ Function|||Subcellular Location Annotation ^@ Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).|||Nucleus http://togogenome.org/gene/9483:DPM1 ^@ http://purl.uniprot.org/uniprot/F6RQC7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum|||Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex. http://togogenome.org/gene/9483:PDE6G ^@ http://purl.uniprot.org/uniprot/A0A2R8MS48 ^@ Function|||Similarity ^@ Belongs to the rod/cone cGMP-PDE gamma subunit family.|||Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. http://togogenome.org/gene/9483:SNRPD1 ^@ http://purl.uniprot.org/uniprot/F7I755 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP core protein family.|||Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Component of the minor spliceosome, which splices U12-type introns. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP. Interacts (via C-terminus) with SMN1 (via Tudor domain); the interaction is direct. Interacts with GEMIN2; the interaction is direct. Interacts with SNRPD2; the interaction is direct.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.|||cytosol http://togogenome.org/gene/9483:HHIPL1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YNE3 ^@ Caution|||Similarity ^@ Belongs to the HHIP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:RAMAC ^@ http://purl.uniprot.org/uniprot/F7HSF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAM family.|||Nucleus http://togogenome.org/gene/9483:CENPM ^@ http://purl.uniprot.org/uniprot/A0A8I3W0D6|||http://purl.uniprot.org/uniprot/U3EJ69 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:CYP2C19 ^@ http://purl.uniprot.org/uniprot/A0A171P0Y8 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9483:GRAMD1A ^@ http://purl.uniprot.org/uniprot/U3E5D9 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:MEX3B ^@ http://purl.uniprot.org/uniprot/F7I6N7 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9483:NIFK ^@ http://purl.uniprot.org/uniprot/F6ZLL0 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9483:PRF1 ^@ http://purl.uniprot.org/uniprot/B5LX20|||http://purl.uniprot.org/uniprot/F7HFF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Secreted http://togogenome.org/gene/9483:LOC108591802 ^@ http://purl.uniprot.org/uniprot/B0VXF6 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9483:SNX19 ^@ http://purl.uniprot.org/uniprot/U3DV52 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9483:HOXA2 ^@ http://purl.uniprot.org/uniprot/B0VXK3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Proboscipedia subfamily.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/9483:HSPA5 ^@ http://purl.uniprot.org/uniprot/U3FXT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 70 family.|||Cell surface|||Endoplasmic reticulum lumen|||Melanosome http://togogenome.org/gene/9483:LSM12 ^@ http://purl.uniprot.org/uniprot/F6THZ7 ^@ Similarity ^@ Belongs to the LSM12 family. http://togogenome.org/gene/9483:TAPT1 ^@ http://purl.uniprot.org/uniprot/F7IG48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAPT1 family.|||Membrane http://togogenome.org/gene/9483:ARL6IP4 ^@ http://purl.uniprot.org/uniprot/F6Y6B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARL6IP4 family.|||Nucleus speckle|||nucleolus http://togogenome.org/gene/9483:CD47 ^@ http://purl.uniprot.org/uniprot/U3D367|||http://purl.uniprot.org/uniprot/U3D4H7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9483:MGMT ^@ http://purl.uniprot.org/uniprot/U3B862 ^@ Function|||Similarity ^@ Belongs to the MGMT family.|||Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. http://togogenome.org/gene/9483:KCNV1 ^@ http://purl.uniprot.org/uniprot/F7ARX6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.|||Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.|||Membrane|||Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes. http://togogenome.org/gene/9483:TP53INP1 ^@ http://purl.uniprot.org/uniprot/F7HJR9 ^@ Subcellular Location Annotation ^@ PML body|||autophagosome|||cytosol http://togogenome.org/gene/9483:TPM3 ^@ http://purl.uniprot.org/uniprot/A0A2R8MKU8|||http://purl.uniprot.org/uniprot/F7I9P7|||http://purl.uniprot.org/uniprot/F7IC14|||http://purl.uniprot.org/uniprot/U3DK87|||http://purl.uniprot.org/uniprot/U3EBA3|||http://purl.uniprot.org/uniprot/U3ELS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9483:GNB4 ^@ http://purl.uniprot.org/uniprot/F7DRF8 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/9483:GSC ^@ http://purl.uniprot.org/uniprot/A0A2R8MTP8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:BOD1 ^@ http://purl.uniprot.org/uniprot/A0A8I3VUW2|||http://purl.uniprot.org/uniprot/F7HA61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BOD1 family.|||centrosome|||kinetochore http://togogenome.org/gene/9483:SLC16A7 ^@ http://purl.uniprot.org/uniprot/U3F5T5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/9483:LOC100394573 ^@ http://purl.uniprot.org/uniprot/F7G6P0 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9483:DOK2 ^@ http://purl.uniprot.org/uniprot/F7CQK8 ^@ Similarity ^@ Belongs to the DOK family. Type A subfamily. http://togogenome.org/gene/9483:CENPT ^@ http://purl.uniprot.org/uniprot/U3DEZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-T/CNN1 family.|||Nucleus|||kinetochore http://togogenome.org/gene/9483:SDHC ^@ http://purl.uniprot.org/uniprot/U3BPE5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.|||Membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). http://togogenome.org/gene/9483:FGF7 ^@ http://purl.uniprot.org/uniprot/F7IBI2 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9483:CCR5 ^@ http://purl.uniprot.org/uniprot/Q9MZA0 ^@ Function|||Similarity ^@ Belongs to the G-protein coupled receptor 1 family.|||Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor. http://togogenome.org/gene/9483:FRAT2 ^@ http://purl.uniprot.org/uniprot/F7GHD6 ^@ Similarity ^@ Belongs to the GSK-3-binding protein family. http://togogenome.org/gene/9483:IGF2 ^@ http://purl.uniprot.org/uniprot/F6XMS3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.|||Secreted http://togogenome.org/gene/9483:ETHE1 ^@ http://purl.uniprot.org/uniprot/U3DFU6 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. http://togogenome.org/gene/9483:EIF3K ^@ http://purl.uniprot.org/uniprot/F7BZF5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit K family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with CCND3, but not with CCND1 and CCND2.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:MTF2 ^@ http://purl.uniprot.org/uniprot/A0A8I3W7H6|||http://purl.uniprot.org/uniprot/F7HGL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Polycomblike family.|||Nucleus http://togogenome.org/gene/9483:DHRS7 ^@ http://purl.uniprot.org/uniprot/F7IQ82 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9483:NR4A2 ^@ http://purl.uniprot.org/uniprot/U3FW56 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family.|||Cytoplasm|||Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.|||Nucleus http://togogenome.org/gene/9483:APOA2 ^@ http://purl.uniprot.org/uniprot/U3CMR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the apolipoprotein A2 family.|||Secreted http://togogenome.org/gene/9483:OR52J3 ^@ http://purl.uniprot.org/uniprot/B0VXA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:GRK7 ^@ http://purl.uniprot.org/uniprot/F7DUK2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9483:SRPX2 ^@ http://purl.uniprot.org/uniprot/F7CN77 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:HM13 ^@ http://purl.uniprot.org/uniprot/A0A8I3W7T5|||http://purl.uniprot.org/uniprot/F7IKY1|||http://purl.uniprot.org/uniprot/U3DHT5|||http://purl.uniprot.org/uniprot/U3FNG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A22B family.|||Membrane http://togogenome.org/gene/9483:CDC42SE1 ^@ http://purl.uniprot.org/uniprot/B0KWB2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CDC42SE/SPEC family.|||Cell membrane|||Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.|||Membrane|||Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.|||cytoskeleton http://togogenome.org/gene/9483:TPR ^@ http://purl.uniprot.org/uniprot/F7IHS3 ^@ Similarity ^@ Belongs to the TPR family. http://togogenome.org/gene/9483:IFNAR1 ^@ http://purl.uniprot.org/uniprot/U3CXP4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II cytokine receptor family.|||Cell membrane|||Endosome|||Heterodimer with IFNAR2.|||Late endosome|||Lysosome|||Membrane|||Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway. http://togogenome.org/gene/9483:RPL26L1 ^@ http://purl.uniprot.org/uniprot/A0A8I3W7N8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Belongs to the universal ribosomal protein uL24 family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane http://togogenome.org/gene/9483:RNF135 ^@ http://purl.uniprot.org/uniprot/A0A8I4A0X6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Nucleus http://togogenome.org/gene/9483:RIOK2 ^@ http://purl.uniprot.org/uniprot/U3D1K8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/9483:HTR4 ^@ http://purl.uniprot.org/uniprot/A0A5F4W988|||http://purl.uniprot.org/uniprot/U3CW94 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Endosome|||Membrane|||This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. http://togogenome.org/gene/9483:SCPEP1 ^@ http://purl.uniprot.org/uniprot/U3FPI9 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/9483:TGFA ^@ http://purl.uniprot.org/uniprot/A0A5F4VXH7|||http://purl.uniprot.org/uniprot/U3E7W0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:ELAVL4 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y0W4|||http://purl.uniprot.org/uniprot/F7AGG7|||http://purl.uniprot.org/uniprot/U3EU91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM elav family.|||Cytoplasm|||Perikaryon|||axon|||dendrite|||growth cone http://togogenome.org/gene/9483:PER2 ^@ http://purl.uniprot.org/uniprot/U3FTY7 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9483:RPS16 ^@ http://purl.uniprot.org/uniprot/F7HKF5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/9483:NLE1 ^@ http://purl.uniprot.org/uniprot/F7GHQ8 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9483:PTPRCAP ^@ http://purl.uniprot.org/uniprot/F7CSZ1 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with CD45/PTPRC.|||Membrane http://togogenome.org/gene/9483:ADH1C ^@ http://purl.uniprot.org/uniprot/A0A5K1V897 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/9483:PPP4C ^@ http://purl.uniprot.org/uniprot/F6S3M7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/9483:DGKA ^@ http://purl.uniprot.org/uniprot/U3FIG2 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic diacylglycerol kinase family.|||Monomer. http://togogenome.org/gene/9483:ATP6V0E1 ^@ http://purl.uniprot.org/uniprot/F7GC30 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase e1/e2 subunit family.|||Membrane|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9483:CCN3 ^@ http://purl.uniprot.org/uniprot/F7HZ48 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9483:PARVG ^@ http://purl.uniprot.org/uniprot/F7H433 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the parvin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:SPAG9 ^@ http://purl.uniprot.org/uniprot/A0A8J8YPZ1|||http://purl.uniprot.org/uniprot/U3DBD1|||http://purl.uniprot.org/uniprot/U3EVG5|||http://purl.uniprot.org/uniprot/U3F0S0 ^@ Similarity ^@ Belongs to the JIP scaffold family. http://togogenome.org/gene/9483:PFDN5 ^@ http://purl.uniprot.org/uniprot/F7BBE6|||http://purl.uniprot.org/uniprot/F7BTR0 ^@ Similarity ^@ Belongs to the prefoldin subunit alpha family. http://togogenome.org/gene/9483:SUPT20H ^@ http://purl.uniprot.org/uniprot/F6XLY6|||http://purl.uniprot.org/uniprot/F7ATN0 ^@ Similarity ^@ Belongs to the SPT20 family. http://togogenome.org/gene/9483:AKR1B10 ^@ http://purl.uniprot.org/uniprot/F7IMQ0 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9483:SEPHS1 ^@ http://purl.uniprot.org/uniprot/U3AXP7 ^@ Function ^@ Synthesizes selenophosphate from selenide and ATP. http://togogenome.org/gene/9483:TAF5L ^@ http://purl.uniprot.org/uniprot/U3F810 ^@ Similarity ^@ Belongs to the WD repeat TAF5 family. http://togogenome.org/gene/9483:ST7 ^@ http://purl.uniprot.org/uniprot/F7HBK2|||http://purl.uniprot.org/uniprot/Q2QLG2|||http://purl.uniprot.org/uniprot/Q2QLG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ST7 family.|||Membrane http://togogenome.org/gene/9483:ITGA5 ^@ http://purl.uniprot.org/uniprot/A0A8I3ZYS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9483:RCL1 ^@ http://purl.uniprot.org/uniprot/U3FH01 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.|||Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.|||nucleolus http://togogenome.org/gene/9483:PGS1 ^@ http://purl.uniprot.org/uniprot/U3EEX4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-II family.|||Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.|||Mitochondrion http://togogenome.org/gene/9483:SBK2 ^@ http://purl.uniprot.org/uniprot/F7IJN5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:ICMT ^@ http://purl.uniprot.org/uniprot/F7GN70 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.|||Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:TRAPPC4 ^@ http://purl.uniprot.org/uniprot/U3C2I8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/9483:HSPB6 ^@ http://purl.uniprot.org/uniprot/F7EBV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Nucleus http://togogenome.org/gene/9483:GPR132 ^@ http://purl.uniprot.org/uniprot/F6T5G8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9483:DBX1 ^@ http://purl.uniprot.org/uniprot/F7FA07 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:ZNF449 ^@ http://purl.uniprot.org/uniprot/F7IKZ3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:RNF141 ^@ http://purl.uniprot.org/uniprot/F7GRH4 ^@ Function ^@ May be involved in spermatogenesis. http://togogenome.org/gene/9483:ADD3 ^@ http://purl.uniprot.org/uniprot/U3C1U3 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/9483:MRPL15 ^@ http://purl.uniprot.org/uniprot/F6VPC6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/9483:KCTD13 ^@ http://purl.uniprot.org/uniprot/U3DBP3 ^@ Similarity ^@ Belongs to the BACURD family. http://togogenome.org/gene/9483:HYOU1 ^@ http://purl.uniprot.org/uniprot/U3FHE6 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9483:LOC103795964 ^@ http://purl.uniprot.org/uniprot/U3DJ54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COA8 family.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:SLC19A2 ^@ http://purl.uniprot.org/uniprot/F7HG40 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.|||Cell membrane|||High-affinity transporter for the intake of thiamine. http://togogenome.org/gene/9483:PNPT1 ^@ http://purl.uniprot.org/uniprot/F7GWJ1 ^@ Similarity ^@ Belongs to the polyribonucleotide nucleotidyltransferase family. http://togogenome.org/gene/9483:CHN2 ^@ http://purl.uniprot.org/uniprot/U3CK98 ^@ Function ^@ GTPase-activating protein for p21-rac. http://togogenome.org/gene/9483:PNRC1 ^@ http://purl.uniprot.org/uniprot/F7AHG5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:CDK2 ^@ http://purl.uniprot.org/uniprot/F7BWH8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:CAMK2N1 ^@ http://purl.uniprot.org/uniprot/F7GNI1 ^@ Similarity ^@ Belongs to the CAMK2N family. http://togogenome.org/gene/9483:DHRS3 ^@ http://purl.uniprot.org/uniprot/U3D2B1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9483:NPY5R ^@ http://purl.uniprot.org/uniprot/U3DXT6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders. http://togogenome.org/gene/9483:BTF3 ^@ http://purl.uniprot.org/uniprot/F6WAJ8 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/9483:SLC31A1 ^@ http://purl.uniprot.org/uniprot/U3B0D6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9483:SF3A2 ^@ http://purl.uniprot.org/uniprot/U3E527 ^@ Similarity ^@ Belongs to the SF3A2 family. http://togogenome.org/gene/9483:LIN54 ^@ http://purl.uniprot.org/uniprot/A0A5F4W2W1|||http://purl.uniprot.org/uniprot/F7GXH3|||http://purl.uniprot.org/uniprot/F7H2K8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-54 family.|||Nucleus http://togogenome.org/gene/9483:TMEM106C ^@ http://purl.uniprot.org/uniprot/F7DTI0 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/9483:MTCH1 ^@ http://purl.uniprot.org/uniprot/F7FJW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9483:SERPINE1 ^@ http://purl.uniprot.org/uniprot/F7I5C2 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9483:MARVELD1 ^@ http://purl.uniprot.org/uniprot/F7A5C4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:ST13 ^@ http://purl.uniprot.org/uniprot/F7HT98 ^@ Similarity ^@ Belongs to the FAM10 family. http://togogenome.org/gene/9483:DEUP1 ^@ http://purl.uniprot.org/uniprot/F7EP69 ^@ Similarity ^@ Belongs to the CEP63 family. http://togogenome.org/gene/9483:LIN9 ^@ http://purl.uniprot.org/uniprot/F7II53|||http://purl.uniprot.org/uniprot/U3DP36 ^@ Similarity ^@ Belongs to the lin-9 family. http://togogenome.org/gene/9483:GFRA1 ^@ http://purl.uniprot.org/uniprot/F7DLH5|||http://purl.uniprot.org/uniprot/U3CT67 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.|||Belongs to the GDNFR family.|||Cell membrane|||Membrane|||Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. http://togogenome.org/gene/9483:ORC5 ^@ http://purl.uniprot.org/uniprot/F7I1U2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:ABRAXAS1 ^@ http://purl.uniprot.org/uniprot/U3D986 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM175 family. Abraxas subfamily.|||Nucleus http://togogenome.org/gene/9483:LRRFIP2 ^@ http://purl.uniprot.org/uniprot/U3B8X9|||http://purl.uniprot.org/uniprot/U3CUM9 ^@ Similarity ^@ Belongs to the LRRFIP family. http://togogenome.org/gene/9483:MAT2A ^@ http://purl.uniprot.org/uniprot/F7F996 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/9483:RC3H1 ^@ http://purl.uniprot.org/uniprot/F6YKI3 ^@ Subcellular Location Annotation ^@ P-body http://togogenome.org/gene/9483:RAB9B ^@ http://purl.uniprot.org/uniprot/F7GKL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||phagosome membrane http://togogenome.org/gene/9483:GPHB5 ^@ http://purl.uniprot.org/uniprot/F7HI76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/9483:DPP7 ^@ http://purl.uniprot.org/uniprot/F7EFW5 ^@ Similarity ^@ Belongs to the peptidase S28 family. http://togogenome.org/gene/9483:SETDB1 ^@ http://purl.uniprot.org/uniprot/U3DWM7 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus http://togogenome.org/gene/9483:C11H11orf87 ^@ http://purl.uniprot.org/uniprot/F7GQ18 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:CHSY3 ^@ http://purl.uniprot.org/uniprot/F7GS31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9483:CALHM4 ^@ http://purl.uniprot.org/uniprot/F7HNE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9483:MYADM ^@ http://purl.uniprot.org/uniprot/F6ZUF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAL family.|||Membrane http://togogenome.org/gene/9483:PDE4B ^@ http://purl.uniprot.org/uniprot/F7IJN3|||http://purl.uniprot.org/uniprot/U3DD68|||http://purl.uniprot.org/uniprot/U3FTI7 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9483:HNRNPR ^@ http://purl.uniprot.org/uniprot/U3FR96 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:TAFA1 ^@ http://purl.uniprot.org/uniprot/U3CAK2 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/9483:MAL ^@ http://purl.uniprot.org/uniprot/F7HP25 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:SNX10 ^@ http://purl.uniprot.org/uniprot/A0A8I3WPZ9|||http://purl.uniprot.org/uniprot/F7IN97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane http://togogenome.org/gene/9483:FOXC2 ^@ http://purl.uniprot.org/uniprot/A0A2R8MRM9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:AGO1 ^@ http://purl.uniprot.org/uniprot/U3DP44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the argonaute family.|||P-body http://togogenome.org/gene/9483:NCOA2 ^@ http://purl.uniprot.org/uniprot/F7C3B2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRC/p160 nuclear receptor coactivator family.|||Nucleus http://togogenome.org/gene/9483:CARMIL1 ^@ http://purl.uniprot.org/uniprot/U3DPX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CARMIL family.|||Cytoplasm http://togogenome.org/gene/9483:TDO2 ^@ http://purl.uniprot.org/uniprot/F7GQ44 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the tryptophan 2,3-dioxygenase family.|||Binds 1 heme group per subunit.|||Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.|||Homotetramer. Dimer of dimers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:UCN3 ^@ http://purl.uniprot.org/uniprot/H9KVL2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Binds with high affinity to CRF receptors 2-alpha and 2-beta.|||Secreted|||Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. http://togogenome.org/gene/9483:CCNDBP1 ^@ http://purl.uniprot.org/uniprot/F7I304 ^@ Similarity|||Subunit ^@ Belongs to the CCNDBP1 family.|||Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3. http://togogenome.org/gene/9483:ESD ^@ http://purl.uniprot.org/uniprot/U3DYQ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the esterase D family.|||Cytoplasmic vesicle|||Serine hydrolase involved in the detoxification of formaldehyde. http://togogenome.org/gene/9483:LAMB1 ^@ http://purl.uniprot.org/uniprot/U3E535 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/9483:ACVRL1 ^@ http://purl.uniprot.org/uniprot/U3FJW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9483:ATP6V1C2 ^@ http://purl.uniprot.org/uniprot/U3DCW2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits. http://togogenome.org/gene/9483:CCND2 ^@ http://purl.uniprot.org/uniprot/F7I947 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9483:MTCH2 ^@ http://purl.uniprot.org/uniprot/F6VE72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9483:CCDC167 ^@ http://purl.uniprot.org/uniprot/U3DSM4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:DOK4 ^@ http://purl.uniprot.org/uniprot/A0A5F4WCM8|||http://purl.uniprot.org/uniprot/U3DIP2 ^@ Similarity ^@ Belongs to the DOK family. Type B subfamily. http://togogenome.org/gene/9483:ACTG2 ^@ http://purl.uniprot.org/uniprot/F6PL61 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9483:LOC100394162 ^@ http://purl.uniprot.org/uniprot/F6RZ51 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9483:PLIN2 ^@ http://purl.uniprot.org/uniprot/A0A8I3WQ03 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/9483:MYO1E ^@ http://purl.uniprot.org/uniprot/U3BT73 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9483:PHAX ^@ http://purl.uniprot.org/uniprot/F7DJT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PHAX family.|||Cytoplasm http://togogenome.org/gene/9483:SEC61A2 ^@ http://purl.uniprot.org/uniprot/A0A8I3WE13|||http://purl.uniprot.org/uniprot/H9KXE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:PNN ^@ http://purl.uniprot.org/uniprot/U3BJN4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pinin family.|||Found in a mRNA splicing-dependent exon junction complex (EJC). Found in a complex with SR proteins. Found in a mRNP complex with RNPS1. Component of the PSAP complex consisting of RNPS1, SAP18 and PNN. Interacts with PNISR, CTBP1, CTBP2, KRT8, KRT18, KRT19, PS1D/PNO40, PPIG, RNPS1, SFRS4 and SRRM2. Identified in the spliceosome C complex.|||Nucleus speckle|||desmosome http://togogenome.org/gene/9483:CPD ^@ http://purl.uniprot.org/uniprot/U3FTT0 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9483:VWA2 ^@ http://purl.uniprot.org/uniprot/F7E354 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:DESI2 ^@ http://purl.uniprot.org/uniprot/U3C837 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/9483:IER3IP1 ^@ http://purl.uniprot.org/uniprot/F7HTN1 ^@ Similarity ^@ Belongs to the YOS1 family. http://togogenome.org/gene/9483:LAPTM4A ^@ http://purl.uniprot.org/uniprot/U3EDB3 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/9483:ZNF500 ^@ http://purl.uniprot.org/uniprot/F6Q7P6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:CDKN2AIPNL ^@ http://purl.uniprot.org/uniprot/A0A8I3VY68 ^@ Similarity ^@ Belongs to the CARF family. http://togogenome.org/gene/9483:ANAPC16 ^@ http://purl.uniprot.org/uniprot/F6X634|||http://purl.uniprot.org/uniprot/U3CQN2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APC16 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|||Cytoplasm|||Nucleus|||kinetochore http://togogenome.org/gene/9483:GPX7 ^@ http://purl.uniprot.org/uniprot/F7I0C6 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/9483:ID1 ^@ http://purl.uniprot.org/uniprot/U3EVS0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:USP45 ^@ http://purl.uniprot.org/uniprot/F7I295 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9483:GSTZ1 ^@ http://purl.uniprot.org/uniprot/A0A7G0XAN9|||http://purl.uniprot.org/uniprot/A0A8I3WCX3 ^@ Similarity ^@ Belongs to the GST superfamily. Zeta family. http://togogenome.org/gene/9483:TRIM35 ^@ http://purl.uniprot.org/uniprot/A0A5F4WL92|||http://purl.uniprot.org/uniprot/U3FRK0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRIM/RBCC family.|||Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:STXBP3 ^@ http://purl.uniprot.org/uniprot/U3D3M4 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9483:FGB ^@ http://purl.uniprot.org/uniprot/F7FU68 ^@ Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted http://togogenome.org/gene/9483:METTL1 ^@ http://purl.uniprot.org/uniprot/U3D6D9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.|||Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.|||Forms a complex with WDR4.|||Nucleus|||Phosphorylation at Ser-27 inactivates its catalytic activity but does not affect the interaction with WDR4. http://togogenome.org/gene/9483:TMEM147 ^@ http://purl.uniprot.org/uniprot/F7GQ14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM147 family.|||Cell membrane|||Endoplasmic reticulum membrane|||Membrane|||Nucleus membrane http://togogenome.org/gene/9483:PTPN12 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y1V2|||http://purl.uniprot.org/uniprot/F7IB84 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.|||Cytoplasm|||Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. http://togogenome.org/gene/9483:CETN2 ^@ http://purl.uniprot.org/uniprot/F6RHT8 ^@ Similarity ^@ Belongs to the centrin family. http://togogenome.org/gene/9483:TMPRSS3 ^@ http://purl.uniprot.org/uniprot/F6WH39|||http://purl.uniprot.org/uniprot/U3C5P2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:CMC1 ^@ http://purl.uniprot.org/uniprot/U3CEM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion http://togogenome.org/gene/9483:PPP2R5E ^@ http://purl.uniprot.org/uniprot/F7DEZ3 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9483:BRI3 ^@ http://purl.uniprot.org/uniprot/F6UK70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BRI3 family.|||Membrane|||perinuclear region http://togogenome.org/gene/9483:POLB ^@ http://purl.uniprot.org/uniprot/F7IKW6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||Cytoplasm|||DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.|||Nucleus http://togogenome.org/gene/9483:RAB21 ^@ http://purl.uniprot.org/uniprot/U3DY75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cleavage furrow|||Early endosome membrane|||Endoplasmic reticulum membrane|||Endosome membrane|||trans-Golgi network http://togogenome.org/gene/9483:HNRNPF ^@ http://purl.uniprot.org/uniprot/U3DCZ9 ^@ Subcellular Location Annotation ^@ nucleoplasm http://togogenome.org/gene/9483:UPP1 ^@ http://purl.uniprot.org/uniprot/F7FUA4 ^@ Function|||Similarity ^@ Belongs to the PNP/UDP phosphorylase family.|||Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. http://togogenome.org/gene/9483:NATD1 ^@ http://purl.uniprot.org/uniprot/H9KXF9 ^@ Similarity ^@ Belongs to the NATD1 family. http://togogenome.org/gene/9483:VANGL2 ^@ http://purl.uniprot.org/uniprot/U3BVQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Vang family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:RNGTT ^@ http://purl.uniprot.org/uniprot/A0A5F4VXZ2|||http://purl.uniprot.org/uniprot/F7BIR3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.|||In the C-terminal section; belongs to the eukaryotic GTase family.|||In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.|||Nucleus http://togogenome.org/gene/9483:PPP2CA ^@ http://purl.uniprot.org/uniprot/U3DKU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/9483:GPR180 ^@ http://purl.uniprot.org/uniprot/A0A2R8P4S7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:CD53 ^@ http://purl.uniprot.org/uniprot/A0A8I3WAT5|||http://purl.uniprot.org/uniprot/F7HHL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9483:RSPO2 ^@ http://purl.uniprot.org/uniprot/U3DVW2 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/9483:ST6GALNAC3 ^@ http://purl.uniprot.org/uniprot/A0A8I4A5R9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9483:ANAPC15 ^@ http://purl.uniprot.org/uniprot/U3C3A1|||http://purl.uniprot.org/uniprot/U3EFC7 ^@ Similarity ^@ Belongs to the APC15 family. http://togogenome.org/gene/9483:APTX ^@ http://purl.uniprot.org/uniprot/A0A8I3WXG5|||http://purl.uniprot.org/uniprot/F7IIK3 ^@ Subcellular Location Annotation ^@ nucleolus|||nucleoplasm http://togogenome.org/gene/9483:CNOT7 ^@ http://purl.uniprot.org/uniprot/F6QE98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/9483:LPAR4 ^@ http://purl.uniprot.org/uniprot/A0A2R8PF80 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9483:TSPAN8 ^@ http://purl.uniprot.org/uniprot/U3BGL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9483:FAM53A ^@ http://purl.uniprot.org/uniprot/U3DKY1 ^@ Similarity ^@ Belongs to the FAM53 family. http://togogenome.org/gene/9483:UBE2B ^@ http://purl.uniprot.org/uniprot/F7HM77 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9483:KRT36 ^@ http://purl.uniprot.org/uniprot/F7C5X7 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9483:USP22 ^@ http://purl.uniprot.org/uniprot/U3DA34 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9483:TIMM50 ^@ http://purl.uniprot.org/uniprot/F7ITE1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM50 family.|||Component of the TIM23 complex.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:ATXN1L ^@ http://purl.uniprot.org/uniprot/F6RTB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATXN1 family.|||Nucleus http://togogenome.org/gene/9483:LOC103794361 ^@ http://purl.uniprot.org/uniprot/A0A2R8PB71 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bZIP family.|||Cytoplasm|||Heterodimer.|||Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.|||Nucleus|||Phosphorylation at serine residues by MAPK14 enhances its transcriptional activation activity while phosphorylation at serine residues by CK2 inhibits its transcriptional activation activity.|||Ubiquitinated, leading to its degradation by the proteasome. http://togogenome.org/gene/9483:IFNGR1 ^@ http://purl.uniprot.org/uniprot/U3FIJ0 ^@ Similarity ^@ Belongs to the type II cytokine receptor family. http://togogenome.org/gene/9483:RHOT1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XLS4|||http://purl.uniprot.org/uniprot/A0A8J8XUP8|||http://purl.uniprot.org/uniprot/A0A8J8XY62|||http://purl.uniprot.org/uniprot/F7I728 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial Rho GTPase family.|||Membrane|||Mitochondrial GTPase involved in mitochondrial trafficking.|||Mitochondrion outer membrane http://togogenome.org/gene/9483:LMBR1L ^@ http://purl.uniprot.org/uniprot/U3DXH0 ^@ Similarity ^@ Belongs to the LIMR family. http://togogenome.org/gene/9483:CHD1 ^@ http://purl.uniprot.org/uniprot/U3E1Z5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:CLCN3 ^@ http://purl.uniprot.org/uniprot/U3EFY2|||http://purl.uniprot.org/uniprot/U3EGL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.|||Cell membrane|||Early endosome membrane|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9483:TAF7 ^@ http://purl.uniprot.org/uniprot/F6SLI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF7 family.|||Nucleus http://togogenome.org/gene/9483:ST6GALNAC6 ^@ http://purl.uniprot.org/uniprot/F7A279|||http://purl.uniprot.org/uniprot/U3DSI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9483:IFRD2 ^@ http://purl.uniprot.org/uniprot/F7IB11 ^@ Similarity ^@ Belongs to the IFRD family. http://togogenome.org/gene/9483:LOC100415497 ^@ http://purl.uniprot.org/uniprot/F7EDV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:PRDM5 ^@ http://purl.uniprot.org/uniprot/A0A2R8MPV1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:RNASE6 ^@ http://purl.uniprot.org/uniprot/F7HRN4 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9483:PDX1 ^@ http://purl.uniprot.org/uniprot/A0A8I3X1E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9483:TSC22D1 ^@ http://purl.uniprot.org/uniprot/A0A8I3W8C9|||http://purl.uniprot.org/uniprot/A0A8I3W8P6|||http://purl.uniprot.org/uniprot/F6TA11 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/9483:HEBP2 ^@ http://purl.uniprot.org/uniprot/F7HWX4 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/9483:COR51P3 ^@ http://purl.uniprot.org/uniprot/B0VXA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:NCK2 ^@ http://purl.uniprot.org/uniprot/F7HUY1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Endoplasmic reticulum http://togogenome.org/gene/9483:RCAN2 ^@ http://purl.uniprot.org/uniprot/U3DR93|||http://purl.uniprot.org/uniprot/U3F3B1 ^@ Function|||Similarity ^@ Belongs to the RCAN family.|||Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. http://togogenome.org/gene/9483:GOLPH3L ^@ http://purl.uniprot.org/uniprot/F7H8H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLPH3/VPS74 family.|||Golgi stack membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9483:SDC2 ^@ http://purl.uniprot.org/uniprot/F7IT99 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane http://togogenome.org/gene/9483:NFE2L2 ^@ http://purl.uniprot.org/uniprot/U3CIU3 ^@ Similarity ^@ Belongs to the bZIP family. CNC subfamily. http://togogenome.org/gene/9483:PPP3R1 ^@ http://purl.uniprot.org/uniprot/F7GNF2 ^@ Similarity ^@ Belongs to the calcineurin regulatory subunit family. http://togogenome.org/gene/9483:GNAT3 ^@ http://purl.uniprot.org/uniprot/F7IEF2 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9483:APOA5 ^@ http://purl.uniprot.org/uniprot/B0KWQ9 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/9483:GOT2 ^@ http://purl.uniprot.org/uniprot/F7GQT4 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/9483:CSK ^@ http://purl.uniprot.org/uniprot/U3BXQ3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9483:BRIX1 ^@ http://purl.uniprot.org/uniprot/F6YS13 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BRX1 family.|||Required for biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/9483:NAA35 ^@ http://purl.uniprot.org/uniprot/U3CWU9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.|||Belongs to the MAK10 family.|||Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.|||Cytoplasm http://togogenome.org/gene/9483:LOC100389034 ^@ http://purl.uniprot.org/uniprot/A0A8I4A4Y0 ^@ Similarity ^@ Belongs to the cytochrome c oxidase VIIa family. http://togogenome.org/gene/9483:PTTG1 ^@ http://purl.uniprot.org/uniprot/F7E3V6|||http://purl.uniprot.org/uniprot/U3FLW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the securin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:PHF20 ^@ http://purl.uniprot.org/uniprot/F6THN4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:EMC8 ^@ http://purl.uniprot.org/uniprot/A0A8I3W6A1|||http://purl.uniprot.org/uniprot/F7IA18 ^@ Similarity ^@ Belongs to the EMC8/EMC9 family. http://togogenome.org/gene/9483:TOE1 ^@ http://purl.uniprot.org/uniprot/F7IFC9 ^@ Similarity ^@ Belongs to the CAF1 family. http://togogenome.org/gene/9483:MAEL ^@ http://purl.uniprot.org/uniprot/F7ICG6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the maelstrom family.|||Nucleus|||Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage. http://togogenome.org/gene/9483:MMS19 ^@ http://purl.uniprot.org/uniprot/U3C261 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MET18/MMS19 family.|||Component of the CIA complex.|||Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.|||Nucleus|||spindle http://togogenome.org/gene/9483:GRM7 ^@ http://purl.uniprot.org/uniprot/F7IRR1|||http://purl.uniprot.org/uniprot/U3ERT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:MRPS15 ^@ http://purl.uniprot.org/uniprot/U3F4J6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/9483:SFT2D2 ^@ http://purl.uniprot.org/uniprot/F7I138 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.|||Membrane http://togogenome.org/gene/9483:GNRHR ^@ http://purl.uniprot.org/uniprot/A0A2R8M762 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:PISD ^@ http://purl.uniprot.org/uniprot/B0KWR7|||http://purl.uniprot.org/uniprot/F7GK51 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.|||Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:UBIAD1 ^@ http://purl.uniprot.org/uniprot/U3EFD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family.|||Membrane http://togogenome.org/gene/9483:NSUN2 ^@ http://purl.uniprot.org/uniprot/F6Y709 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||extracellular exosome http://togogenome.org/gene/9483:SAA4 ^@ http://purl.uniprot.org/uniprot/A0A8I3WMR8 ^@ Function|||Similarity ^@ Belongs to the SAA family.|||Major acute phase reactant. Apolipoprotein of the HDL complex. http://togogenome.org/gene/9483:ETF1 ^@ http://purl.uniprot.org/uniprot/U3FM72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic release factor 1 family.|||Cytoplasm http://togogenome.org/gene/9483:RSRP1 ^@ http://purl.uniprot.org/uniprot/U3BF28 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RSRP family.|||Nucleus|||Probably acts as a spliceosomal factor that contributes to spliceosome assembly and regulates the isoform switching of proteins such as PARP6. http://togogenome.org/gene/9483:VWC2 ^@ http://purl.uniprot.org/uniprot/F7CDJ2 ^@ Subcellular Location Annotation ^@ Synapse http://togogenome.org/gene/9483:GALNT6 ^@ http://purl.uniprot.org/uniprot/F6R4R7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:MED26 ^@ http://purl.uniprot.org/uniprot/F7CC97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 26 family.|||Nucleus http://togogenome.org/gene/9483:TOMM20 ^@ http://purl.uniprot.org/uniprot/F6TRU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom20 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9483:LOC100894850 ^@ http://purl.uniprot.org/uniprot/A0A8I3VX86 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/9483:FIS1 ^@ http://purl.uniprot.org/uniprot/F6UJN3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FIS1 family.|||Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.|||Membrane|||Mitochondrion outer membrane|||The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission. http://togogenome.org/gene/9483:BIRC2 ^@ http://purl.uniprot.org/uniprot/U3D8L7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IAP family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:RNF8 ^@ http://purl.uniprot.org/uniprot/F6YTA4 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ According to a well-established model, RNF8 initiate H2A 'Lys-63'-linked ubiquitination leading to recruitment of RNF168 to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.|||Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger.|||Belongs to the CHFR family.|||Belongs to the RNF8 family.|||Cytoplasm|||E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains. Promotes non-homologous end joining (NHEJ) by promoting the 'Lys-48'-linked ubiquitination and degradation the of KU80/XRCC5. Following DNA damage, mediates the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF168, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Following DNA damage, mediates the ubiquitination and degradation of POLD4/p12, a subunit of DNA polymerase delta. In the absence of POLD4, DNA polymerase delta complex exhibits higher proofreading activity. In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation. Involved in the activation of ATM by promoting histone H2B ubiquitination, which indirectly triggers histone H4 'Lys-16' acetylation (H4K16ac), establishing a chromatin environment that promotes efficient activation of ATM kinase. Required in the testis, where it plays a role in the replacement of histones during spermatogenesis. At uncapped telomeres, promotes the joining of deprotected chromosome ends by inducing H2A ubiquitination and TP53BP1 recruitment, suggesting that it may enhance cancer development by aggravating telomere-induced genome instability in case of telomeric crisis. Promotes the assembly of RAD51 at DNA DSBs in the absence of BRCA1 and TP53BP1 Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. May be required for proper exit from mitosis after spindle checkpoint activation and may regulate cytokinesis. May play a role in the regulation of RXRA-mediated transcriptional activity. Not involved in RXRA ubiquitination by UBE2E2.|||Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N. Interacts with RXRA. Interacts (via FHA domain) with phosphorylated HERC2 (via C-terminus). Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm.|||Midbody|||Nucleus|||The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and phosphorylated HERC2.|||telomere http://togogenome.org/gene/9483:SMIM7 ^@ http://purl.uniprot.org/uniprot/U3DUY0 ^@ Similarity ^@ Belongs to the SMIM7 family. http://togogenome.org/gene/9483:CDYL ^@ http://purl.uniprot.org/uniprot/U3BH98 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:ACP7 ^@ http://purl.uniprot.org/uniprot/F7BW71 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family. http://togogenome.org/gene/9483:LOC100405984 ^@ http://purl.uniprot.org/uniprot/A0A2R8MJ11|||http://purl.uniprot.org/uniprot/A0A5K1UBD5|||http://purl.uniprot.org/uniprot/A0A7G0Y579|||http://purl.uniprot.org/uniprot/A0A7G3HP95|||http://purl.uniprot.org/uniprot/B0KW78|||http://purl.uniprot.org/uniprot/F7CQQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9483:UCP3 ^@ http://purl.uniprot.org/uniprot/A0A2R8MR09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9483:TRIM44 ^@ http://purl.uniprot.org/uniprot/A0A8I3WIK4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:TMEM177 ^@ http://purl.uniprot.org/uniprot/F7I6M8 ^@ Function|||Similarity ^@ Belongs to the TMEM177 family.|||Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein. http://togogenome.org/gene/9483:CBR1 ^@ http://purl.uniprot.org/uniprot/U3BU94 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9483:NPRL2 ^@ http://purl.uniprot.org/uniprot/F7EGD3 ^@ Similarity ^@ Belongs to the NPR2 family. http://togogenome.org/gene/9483:JAK1 ^@ http://purl.uniprot.org/uniprot/U3BR01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.|||Endomembrane system http://togogenome.org/gene/9483:EIF5 ^@ http://purl.uniprot.org/uniprot/A0A5F4WHF4 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/9483:NDUFA5 ^@ http://purl.uniprot.org/uniprot/F7GKU5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA5 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:RSBN1L ^@ http://purl.uniprot.org/uniprot/F7I6G4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the round spermatid basic protein 1 family.|||Nucleus http://togogenome.org/gene/9483:TMEM126A ^@ http://purl.uniprot.org/uniprot/F7II27|||http://purl.uniprot.org/uniprot/U3D466 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:ALKBH7 ^@ http://purl.uniprot.org/uniprot/U3CWP8 ^@ Similarity ^@ Belongs to the alkB family. http://togogenome.org/gene/9483:POU4F3 ^@ http://purl.uniprot.org/uniprot/A0A8I3WMQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/9483:SLC6A1 ^@ http://purl.uniprot.org/uniprot/U3ENW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9483:CDH11 ^@ http://purl.uniprot.org/uniprot/U3ESL0 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:FABP1 ^@ http://purl.uniprot.org/uniprot/F7FL19 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.|||Cytoplasm|||Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. http://togogenome.org/gene/9483:CLK2 ^@ http://purl.uniprot.org/uniprot/F7H9U4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:RBBP5 ^@ http://purl.uniprot.org/uniprot/U3DAP2|||http://purl.uniprot.org/uniprot/U3DM12 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:SLC24A4 ^@ http://purl.uniprot.org/uniprot/F6PIT7|||http://purl.uniprot.org/uniprot/U3D277 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/9483:RGS4 ^@ http://purl.uniprot.org/uniprot/F6RJK3 ^@ Function ^@ Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. http://togogenome.org/gene/9483:SLC66A2 ^@ http://purl.uniprot.org/uniprot/U3DGM0|||http://purl.uniprot.org/uniprot/U3DRZ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:TMEFF2 ^@ http://purl.uniprot.org/uniprot/U3ETB1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:SERPINB2 ^@ http://purl.uniprot.org/uniprot/B0CMA9 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9483:MTX3 ^@ http://purl.uniprot.org/uniprot/A0A8I3X2L5|||http://purl.uniprot.org/uniprot/F7EW54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metaxin family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9483:NTN4 ^@ http://purl.uniprot.org/uniprot/F6UDK1|||http://purl.uniprot.org/uniprot/U3CXF1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:CCND3 ^@ http://purl.uniprot.org/uniprot/F6XJP1 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9483:XPO5 ^@ http://purl.uniprot.org/uniprot/F6YW59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm http://togogenome.org/gene/9483:ERI1 ^@ http://purl.uniprot.org/uniprot/U3B7N9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:MAK16 ^@ http://purl.uniprot.org/uniprot/F7IJ04 ^@ Similarity ^@ Belongs to the MAK16 family. http://togogenome.org/gene/9483:NOVA1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YB89|||http://purl.uniprot.org/uniprot/F7HNQ2|||http://purl.uniprot.org/uniprot/U3E811 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with PTBP2; the interaction is direct.|||Nucleus http://togogenome.org/gene/9483:CACNG3 ^@ http://purl.uniprot.org/uniprot/F7HXI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane http://togogenome.org/gene/9483:SEMA3C ^@ http://purl.uniprot.org/uniprot/F7GWN2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9483:PCOLCE2 ^@ http://purl.uniprot.org/uniprot/U3B985 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9483:CXCL6 ^@ http://purl.uniprot.org/uniprot/A0A2R8N9E7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9483:COX11 ^@ http://purl.uniprot.org/uniprot/U3DRV0 ^@ Function|||Subcellular Location Annotation ^@ Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:UQCC ^@ http://purl.uniprot.org/uniprot/U3C6V7 ^@ Similarity ^@ Belongs to the CBP3 family. http://togogenome.org/gene/9483:VPS37A ^@ http://purl.uniprot.org/uniprot/U3CKF9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9483:PYCR2 ^@ http://purl.uniprot.org/uniprot/L7N0W5|||http://purl.uniprot.org/uniprot/U3CV44 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/9483:RNF170 ^@ http://purl.uniprot.org/uniprot/U3CM22 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:INSL6 ^@ http://purl.uniprot.org/uniprot/F7CZ41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/9483:INPP4A ^@ http://purl.uniprot.org/uniprot/F6W0Q3 ^@ Similarity ^@ Belongs to the inositol 3,4-bisphosphate 4-phosphatase family. http://togogenome.org/gene/9483:SOAT2 ^@ http://purl.uniprot.org/uniprot/F6T271 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:TERF1 ^@ http://purl.uniprot.org/uniprot/F7IQX2|||http://purl.uniprot.org/uniprot/F7IQX6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.|||Homodimer.|||Nucleus|||telomere http://togogenome.org/gene/9483:CPEB3 ^@ http://purl.uniprot.org/uniprot/A0A8I3XDC5 ^@ Similarity ^@ Belongs to the RRM CPEB family. http://togogenome.org/gene/9483:DDX18 ^@ http://purl.uniprot.org/uniprot/U3F396 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9483:GSTM3 ^@ http://purl.uniprot.org/uniprot/F6TIC3 ^@ Similarity|||Subunit ^@ Belongs to the GST superfamily. Mu family.|||Homodimer. http://togogenome.org/gene/9483:TAF12 ^@ http://purl.uniprot.org/uniprot/A0A2R8MY15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF12 family.|||Nucleus http://togogenome.org/gene/9483:SFRP5 ^@ http://purl.uniprot.org/uniprot/F6ZL04 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:TMEM131 ^@ http://purl.uniprot.org/uniprot/A0A8I3X1T4|||http://purl.uniprot.org/uniprot/F6TUN3 ^@ Similarity ^@ Belongs to the TMEM131 family. http://togogenome.org/gene/9483:SRP72 ^@ http://purl.uniprot.org/uniprot/U3CLM3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP72 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).|||Cytoplasm http://togogenome.org/gene/9483:SP4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ME16 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:MRPL3 ^@ http://purl.uniprot.org/uniprot/A0A2R8PK74|||http://purl.uniprot.org/uniprot/F7IC72 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/9483:NDFIP2 ^@ http://purl.uniprot.org/uniprot/A0A5F4VQP6 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Membrane http://togogenome.org/gene/9483:QPCT ^@ http://purl.uniprot.org/uniprot/A0A8I3X3E4|||http://purl.uniprot.org/uniprot/F6PIC3 ^@ Similarity ^@ Belongs to the glutaminyl-peptide cyclotransferase family. http://togogenome.org/gene/9483:BTAF1 ^@ http://purl.uniprot.org/uniprot/A0A2R8MUK8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:EFNA4 ^@ http://purl.uniprot.org/uniprot/F7A539 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:IRF2BP1 ^@ http://purl.uniprot.org/uniprot/U3CWM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF2BP family.|||Nucleus http://togogenome.org/gene/9483:PIK3CB ^@ http://purl.uniprot.org/uniprot/F7CM33 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9483:NHEJ1 ^@ http://purl.uniprot.org/uniprot/U3EJC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XRCC4-XLF family. XLF subfamily.|||Nucleus http://togogenome.org/gene/9483:DUOXA1 ^@ http://purl.uniprot.org/uniprot/U3ARF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DUOXA family.|||Membrane http://togogenome.org/gene/9483:PLAT ^@ http://purl.uniprot.org/uniprot/F7HV58 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9483:TBCA ^@ http://purl.uniprot.org/uniprot/F7HGE1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TBCA family.|||Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.|||Tubulin-folding protein; involved in the early step of the tubulin folding pathway.|||cytoskeleton http://togogenome.org/gene/9483:ZCCHC4 ^@ http://purl.uniprot.org/uniprot/U3C004 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZCCHC4 family.|||Cytoplasm|||nucleolus http://togogenome.org/gene/9483:LOC108589623 ^@ http://purl.uniprot.org/uniprot/F7FDP2 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL31 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/9483:RABAC1 ^@ http://purl.uniprot.org/uniprot/F7I8Z0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/9483:SLC17A6 ^@ http://purl.uniprot.org/uniprot/U3C834 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:NDUFV1 ^@ http://purl.uniprot.org/uniprot/U3BG69 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I 51 kDa subunit family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:PPP3CA ^@ http://purl.uniprot.org/uniprot/U3B0P1 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-2B subfamily. http://togogenome.org/gene/9483:TMED10 ^@ http://purl.uniprot.org/uniprot/U3ED30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:GHSR ^@ http://purl.uniprot.org/uniprot/A5A4L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:LOC100397482 ^@ http://purl.uniprot.org/uniprot/U3CM30 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9483:SUGCT ^@ http://purl.uniprot.org/uniprot/U3CGC2 ^@ Similarity ^@ Belongs to the CoA-transferase III family. http://togogenome.org/gene/9483:SGPL1 ^@ http://purl.uniprot.org/uniprot/U3DE76 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/9483:NKX2-2 ^@ http://purl.uniprot.org/uniprot/F7I8G9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:PPIL1 ^@ http://purl.uniprot.org/uniprot/A0A8I4A5R6 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9483:SMDT1 ^@ http://purl.uniprot.org/uniprot/H9KVS5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMDT1/EMRE family.|||Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.|||Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9483:RFT1 ^@ http://purl.uniprot.org/uniprot/U3D1L4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RFT1 family.|||May be involved in N-linked oligosaccharide assembly.|||Membrane http://togogenome.org/gene/9483:MACIR ^@ http://purl.uniprot.org/uniprot/F7BMU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UNC119-binding protein family.|||Cytoplasm|||cilium http://togogenome.org/gene/9483:OTOP3 ^@ http://purl.uniprot.org/uniprot/F7G708 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the otopetrin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:ANKH ^@ http://purl.uniprot.org/uniprot/F7D3S3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANKH family.|||Membrane|||Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter. http://togogenome.org/gene/9483:HENMT1 ^@ http://purl.uniprot.org/uniprot/U3DYW0 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. HEN1 family. http://togogenome.org/gene/9483:RWDD3 ^@ http://purl.uniprot.org/uniprot/U3E9M5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9483:HOMER1 ^@ http://purl.uniprot.org/uniprot/F6T045 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Homer family.|||Cytoplasm|||Postsynaptic density|||Synapse http://togogenome.org/gene/9483:NRG1 ^@ http://purl.uniprot.org/uniprot/A0A2R8MUP3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neuregulin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:CRYBA4 ^@ http://purl.uniprot.org/uniprot/F7GZ12 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9483:HOXD10 ^@ http://purl.uniprot.org/uniprot/F7G643 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9483:NOSTRIN ^@ http://purl.uniprot.org/uniprot/A0A8I3W1J0 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9483:COG3 ^@ http://purl.uniprot.org/uniprot/U3FGZ3 ^@ Function|||Similarity ^@ Belongs to the COG3 family.|||Involved in ER-Golgi transport. http://togogenome.org/gene/9483:PIGO ^@ http://purl.uniprot.org/uniprot/U3F7U1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:BARHL2 ^@ http://purl.uniprot.org/uniprot/F7CVL1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:KIFBP ^@ http://purl.uniprot.org/uniprot/F7HIC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KIF-binding protein family.|||cytoskeleton http://togogenome.org/gene/9483:TET3 ^@ http://purl.uniprot.org/uniprot/F7GQB9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TET family.|||Binds 1 Fe(2+) ion per subunit.|||Chromosome|||Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.|||The zinc ions have a structural role. http://togogenome.org/gene/9483:GTF2F2 ^@ http://purl.uniprot.org/uniprot/U3CFI4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIF beta subunit family.|||Nucleus|||TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. http://togogenome.org/gene/9483:DGKG ^@ http://purl.uniprot.org/uniprot/A0A8J8XUE2|||http://purl.uniprot.org/uniprot/F7GI17 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/9483:ITM2A ^@ http://purl.uniprot.org/uniprot/U3DP04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITM2 family.|||Membrane http://togogenome.org/gene/9483:POLR3A ^@ http://purl.uniprot.org/uniprot/A0A8I3WWW7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA polymerase beta' chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/9483:ARR3 ^@ http://purl.uniprot.org/uniprot/F7IME6 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9483:LPGAT1 ^@ http://purl.uniprot.org/uniprot/U3E0V8 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9483:EMG1 ^@ http://purl.uniprot.org/uniprot/F6YHU5 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family. http://togogenome.org/gene/9483:SNX9 ^@ http://purl.uniprot.org/uniprot/U3EQV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane http://togogenome.org/gene/9483:RAD21 ^@ http://purl.uniprot.org/uniprot/F7HYV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad21 family.|||Nucleus http://togogenome.org/gene/9483:SYNM ^@ http://purl.uniprot.org/uniprot/U3BFC6|||http://purl.uniprot.org/uniprot/U3C005 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9483:PRLR ^@ http://purl.uniprot.org/uniprot/F7BTT9|||http://purl.uniprot.org/uniprot/Q9N0J7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||Interacts with SMARCA1. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.|||Membrane|||The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.|||The box 1 motif is required for JAK interaction and/or activation.|||This is a receptor for the anterior pituitary hormone prolactin. http://togogenome.org/gene/9483:DOCK3 ^@ http://purl.uniprot.org/uniprot/U3FQQ1 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9483:ZDHHC20 ^@ http://purl.uniprot.org/uniprot/U3F9W8 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9483:CXCR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8N9I8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:LOC100411174 ^@ http://purl.uniprot.org/uniprot/A0A8I3WKB8 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9483:AMDHD1 ^@ http://purl.uniprot.org/uniprot/A0A8I4A0F1 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. HutI family. http://togogenome.org/gene/9483:TRAPPC3 ^@ http://purl.uniprot.org/uniprot/A0A2R8NCA5|||http://purl.uniprot.org/uniprot/U3EHE1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||Homodimer.|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||cis-Golgi network http://togogenome.org/gene/9483:MFAP5 ^@ http://purl.uniprot.org/uniprot/U3DPH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MFAP family.|||extracellular matrix http://togogenome.org/gene/9483:LIFR ^@ http://purl.uniprot.org/uniprot/U3C6U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/9483:EXOC5 ^@ http://purl.uniprot.org/uniprot/F7I3U0 ^@ Similarity ^@ Belongs to the SEC10 family. http://togogenome.org/gene/9483:RPS23 ^@ http://purl.uniprot.org/uniprot/F7H6F1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS12 family.|||Rough endoplasmic reticulum http://togogenome.org/gene/9483:EIF2B4 ^@ http://purl.uniprot.org/uniprot/F7E415|||http://purl.uniprot.org/uniprot/U3D8F9 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/9483:GPAM ^@ http://purl.uniprot.org/uniprot/A0A8I3W879 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPAT/DAPAT family.|||Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.|||Mitochondrion outer membrane http://togogenome.org/gene/9483:CACUL1 ^@ http://purl.uniprot.org/uniprot/F7GMU9 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9483:MAP2K5 ^@ http://purl.uniprot.org/uniprot/A0A8I3W005|||http://purl.uniprot.org/uniprot/F7EJV6|||http://purl.uniprot.org/uniprot/F7GFU7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:TBL1X ^@ http://purl.uniprot.org/uniprot/A0A5F4W3X1 ^@ Similarity ^@ Belongs to the WD repeat EBI family. http://togogenome.org/gene/9483:SPPL2A ^@ http://purl.uniprot.org/uniprot/A0A8I3W3L8|||http://purl.uniprot.org/uniprot/A0A8I3WJM1|||http://purl.uniprot.org/uniprot/U3DW22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A22B family.|||Endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9483:FAM120B ^@ http://purl.uniprot.org/uniprot/A0A8I3W7S6 ^@ Similarity ^@ Belongs to the constitutive coactivator of PPAR-gamma family. http://togogenome.org/gene/9483:GIPC2 ^@ http://purl.uniprot.org/uniprot/F7CET3 ^@ Similarity ^@ Belongs to the GIPC family. http://togogenome.org/gene/9483:MAPK7 ^@ http://purl.uniprot.org/uniprot/U3BIE1 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9483:PTPRM ^@ http://purl.uniprot.org/uniprot/U3DG90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.|||Membrane http://togogenome.org/gene/9483:MANBAL ^@ http://purl.uniprot.org/uniprot/U3CSW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0239 family.|||Membrane http://togogenome.org/gene/9483:NOL11 ^@ http://purl.uniprot.org/uniprot/F7GSB7 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9483:GPRC5C ^@ http://purl.uniprot.org/uniprot/F7GH50 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9483:TFPI ^@ http://purl.uniprot.org/uniprot/U3E227 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9483:DAD1 ^@ http://purl.uniprot.org/uniprot/U3CZS1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DAD/OST2 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/9483:RPS20 ^@ http://purl.uniprot.org/uniprot/U3ECY8 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Component of the 40S small ribosomal subunit. http://togogenome.org/gene/9483:RAB38 ^@ http://purl.uniprot.org/uniprot/F7FQR9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/9483:UNC119B ^@ http://purl.uniprot.org/uniprot/F7IL48 ^@ Similarity ^@ Belongs to the PDE6D/unc-119 family. http://togogenome.org/gene/9483:ESRRB ^@ http://purl.uniprot.org/uniprot/F7IDY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/9483:SCGB1A1 ^@ http://purl.uniprot.org/uniprot/F7I6D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the secretoglobin family.|||Secreted http://togogenome.org/gene/9483:DDA1 ^@ http://purl.uniprot.org/uniprot/A0A8I3WNF3 ^@ Similarity ^@ Belongs to the DDA1 family. http://togogenome.org/gene/9483:IL1A ^@ http://purl.uniprot.org/uniprot/F6VT34 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-1 family.|||Cytoplasm|||Monomer.|||Nucleus|||Secreted http://togogenome.org/gene/9483:EEF1AKMT1 ^@ http://purl.uniprot.org/uniprot/F7I5P1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.|||Cytoplasm|||Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.|||Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure. http://togogenome.org/gene/9483:RPF1 ^@ http://purl.uniprot.org/uniprot/F7CAZ0 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9483:LOC108590593 ^@ http://purl.uniprot.org/uniprot/F7H244 ^@ Similarity ^@ Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family. http://togogenome.org/gene/9483:NAA25 ^@ http://purl.uniprot.org/uniprot/F7IPZ6 ^@ Similarity ^@ Belongs to the MDM20/NAA25 family. http://togogenome.org/gene/9483:CCNJ ^@ http://purl.uniprot.org/uniprot/F6YW04|||http://purl.uniprot.org/uniprot/F7I9P2 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9483:TMEM38A ^@ http://purl.uniprot.org/uniprot/U3DTE2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM38 family.|||Membrane|||Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. http://togogenome.org/gene/9483:SERINC1 ^@ http://purl.uniprot.org/uniprot/U3E8Q5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9483:YOD1 ^@ http://purl.uniprot.org/uniprot/F7CPY9 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin. http://togogenome.org/gene/9483:DNASE1L1 ^@ http://purl.uniprot.org/uniprot/B0KWW7 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/9483:EFNA3 ^@ http://purl.uniprot.org/uniprot/F6ZM25 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:LOC100410976 ^@ http://purl.uniprot.org/uniprot/B0VXB4 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9483:CSTB ^@ http://purl.uniprot.org/uniprot/U3EM28 ^@ Similarity ^@ Belongs to the cystatin family. http://togogenome.org/gene/9483:NFIA ^@ http://purl.uniprot.org/uniprot/A0A2R8M331|||http://purl.uniprot.org/uniprot/A0A8I3WQB5|||http://purl.uniprot.org/uniprot/F7I562|||http://purl.uniprot.org/uniprot/U3CME0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTF/NF-I family.|||Binds DNA as a homodimer.|||Nucleus|||Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. http://togogenome.org/gene/9483:MEGF10 ^@ http://purl.uniprot.org/uniprot/F7H7X5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:DENND10 ^@ http://purl.uniprot.org/uniprot/U3CI95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DENND10 family.|||Endosome|||Late endosome http://togogenome.org/gene/9483:MYO1D ^@ http://purl.uniprot.org/uniprot/F7IG85 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9483:CCL28 ^@ http://purl.uniprot.org/uniprot/A0A8I3WF05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9483:PPEF1 ^@ http://purl.uniprot.org/uniprot/A0A5F4VSH6 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/9483:MIPEP ^@ http://purl.uniprot.org/uniprot/F7IG38 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/9483:TMBIM4 ^@ http://purl.uniprot.org/uniprot/U3DZ75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9483:INSL3 ^@ http://purl.uniprot.org/uniprot/O97937 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the insulin family.|||Heterodimer of a B chain and an A chain linked by two disulfide bonds.|||Highest expression in the Leydig cells of the testis.|||Secreted|||Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). http://togogenome.org/gene/9483:ACTR3B ^@ http://purl.uniprot.org/uniprot/U3FMY2 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9483:LPCAT3 ^@ http://purl.uniprot.org/uniprot/U3BQ17 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:CERCAM ^@ http://purl.uniprot.org/uniprot/F6UXA1 ^@ Similarity ^@ Belongs to the glycosyltransferase 25 family. http://togogenome.org/gene/9483:IL21 ^@ http://purl.uniprot.org/uniprot/F7I3A3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Secreted http://togogenome.org/gene/9483:IL2 ^@ http://purl.uniprot.org/uniprot/Q0PIT4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-2 family.|||Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.|||Secreted http://togogenome.org/gene/9483:CYP27A1 ^@ http://purl.uniprot.org/uniprot/A0A7G0X095 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9483:LOC100399426 ^@ http://purl.uniprot.org/uniprot/F7G6P0 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9483:SLC2A8 ^@ http://purl.uniprot.org/uniprot/F6SK66 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/9483:SMC3 ^@ http://purl.uniprot.org/uniprot/U3DCF6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC3 subfamily.|||Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.|||Nucleus|||centromere http://togogenome.org/gene/9483:NRG3 ^@ http://purl.uniprot.org/uniprot/A0A2R8MMV8|||http://purl.uniprot.org/uniprot/A0A2R8MX98 ^@ Caution|||Similarity ^@ Belongs to the neuregulin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:PSPC1 ^@ http://purl.uniprot.org/uniprot/F7I3U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PSPC family.|||Cytoplasm|||Nucleus matrix|||Nucleus speckle|||nucleolus http://togogenome.org/gene/9483:HS2ST1 ^@ http://purl.uniprot.org/uniprot/U3BYE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 3 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:CLTB ^@ http://purl.uniprot.org/uniprot/F7ID71|||http://purl.uniprot.org/uniprot/F7ID77 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin light chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||coated pit http://togogenome.org/gene/9483:LOC100404679 ^@ http://purl.uniprot.org/uniprot/A0A2R8MU93 ^@ Subcellular Location Annotation|||Subunit ^@ Membrane|||The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta. http://togogenome.org/gene/9483:ST6GALNAC2 ^@ http://purl.uniprot.org/uniprot/F7H4E4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9483:ST8SIA4 ^@ http://purl.uniprot.org/uniprot/U3BGW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9483:MOGS ^@ http://purl.uniprot.org/uniprot/F7E1L8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 63 family.|||Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9483:CASP2 ^@ http://purl.uniprot.org/uniprot/F7I2T9 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9483:PIERCE2 ^@ http://purl.uniprot.org/uniprot/U3CVN2 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.|||cilium axoneme http://togogenome.org/gene/9483:IDI1 ^@ http://purl.uniprot.org/uniprot/U3BH55 ^@ Function|||Similarity ^@ Belongs to the IPP isomerase type 1 family.|||Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). http://togogenome.org/gene/9483:LOC100392213 ^@ http://purl.uniprot.org/uniprot/A0A5F4W2J6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9483:KIT ^@ http://purl.uniprot.org/uniprot/Q76II0|||http://purl.uniprot.org/uniprot/U3CN62|||http://purl.uniprot.org/uniprot/U3EUB3 ^@ Activity Regulation|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Autophosphorylated on tyrosine residues. KITLG/SCF binding promotes autophosphorylation. Phosphorylated tyrosine residues are important for interaction with specific binding partners (By similarity).|||Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane|||Monomer in the absence of bound KITLG/SCF. Homodimer in the presence of bound KITLG/SCF, forming a heterotetramer with two KITLG/SCF molecules. Interacts (via phosphorylated tyrosine residues) with the adapter proteins GRB2 and GRB7 (via SH2 domain), and SH2B2/APS. Interacts (via C-terminus) with MPDZ (via the tenth PDZ domain). Interacts (via phosphorylated tyrosine residues) with PIK3R1 and PIK3CD. Interacts (via phosphorylated tyrosine) with CRK (isoform Crk-II), FYN, SHC1 and MATK/CHK (via SH2 domain). Interacts with LYN and FES/FPS. Interacts (via phosphorylated tyrosine residues) with the protein phosphatases PTPN6/SHP-1 (via SH2 domain), PTPN11/SHP-2 (via SH2 domain) and PTPRU. Interacts with PLCG1. Interacts with DOK1 and TEC. Interacts with IL1RAP (independent of stimulation with KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88 (By similarity).|||Numerous proteins are phosphorylated in response to KIT signaling, but it is not evident to determine which are directly phosphorylated by KIT under in vivo conditions.|||Present in an inactive conformation in the absence of bound ligand. KITLG/SCF binding leads to dimerization and activation by autophosphorylation on tyrosine residues. Activity is down-regulated by PRKCA-mediated phosphorylation on serine residues (By similarity).|||Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1 (By similarity).|||Ubiquitinated by SOCS6. KIT is rapidly ubiquitinated after autophosphorylation induced by KITLG/SCF binding, leading to internalization and degradation. http://togogenome.org/gene/9483:EPHX1 ^@ http://purl.uniprot.org/uniprot/F7IDL6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S33 family.|||Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9483:PTPN14 ^@ http://purl.uniprot.org/uniprot/A0A5F4VSV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||cytoskeleton http://togogenome.org/gene/9483:TMTC3 ^@ http://purl.uniprot.org/uniprot/U3EIN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/9483:ZNF18 ^@ http://purl.uniprot.org/uniprot/A0A2R8MCE1|||http://purl.uniprot.org/uniprot/F7HMB1|||http://purl.uniprot.org/uniprot/U3CC84 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:IK ^@ http://purl.uniprot.org/uniprot/U3F464 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RED family.|||Nucleus http://togogenome.org/gene/9483:STK10 ^@ http://purl.uniprot.org/uniprot/F7HI69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Cell membrane http://togogenome.org/gene/9483:SPACA5 ^@ http://purl.uniprot.org/uniprot/F7ALE5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9483:KAT8 ^@ http://purl.uniprot.org/uniprot/F7HL51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/9483:ATP5PF ^@ http://purl.uniprot.org/uniprot/A0A2R8PKJ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ATPase subunit F6 family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.|||Mitochondrion|||Mitochondrion inner membrane http://togogenome.org/gene/9483:SMAD1 ^@ http://purl.uniprot.org/uniprot/U3D284 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:SFTPC ^@ http://purl.uniprot.org/uniprot/U3EVB1 ^@ Function|||Subcellular Location Annotation ^@ Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.|||surface film http://togogenome.org/gene/9483:TBPL1 ^@ http://purl.uniprot.org/uniprot/U3DHA7 ^@ Similarity|||Subunit ^@ Belongs to the TBP family.|||Binds TFIIA and TFIIB. http://togogenome.org/gene/9483:SPAG7 ^@ http://purl.uniprot.org/uniprot/F7I1A9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:TMEM9 ^@ http://purl.uniprot.org/uniprot/A0A8I3WNP0 ^@ Similarity ^@ Belongs to the TMEM9 family. http://togogenome.org/gene/9483:OPRD1 ^@ http://purl.uniprot.org/uniprot/F7IJ84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:TRMT112 ^@ http://purl.uniprot.org/uniprot/F6Q6G2 ^@ Similarity ^@ Belongs to the TRM112 family. http://togogenome.org/gene/9483:CA4 ^@ http://purl.uniprot.org/uniprot/U3DPM7 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9483:SGCG ^@ http://purl.uniprot.org/uniprot/F7HWH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/9483:ATG13 ^@ http://purl.uniprot.org/uniprot/F6YCQ9|||http://purl.uniprot.org/uniprot/U3CX99|||http://purl.uniprot.org/uniprot/U3DRN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.|||Belongs to the ATG13 family. Metazoan subfamily.|||Preautophagosomal structure http://togogenome.org/gene/9483:ATP5MC3 ^@ http://purl.uniprot.org/uniprot/F7HAG9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/9483:CCT3 ^@ http://purl.uniprot.org/uniprot/F7HMY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9483:EIF4H ^@ http://purl.uniprot.org/uniprot/U3BSU7 ^@ Function|||Subcellular Location Annotation ^@ Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.|||perinuclear region http://togogenome.org/gene/9483:UBE2D2 ^@ http://purl.uniprot.org/uniprot/U3DVQ8 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9483:LOC100415625 ^@ http://purl.uniprot.org/uniprot/A0A5F4WEM7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/9483:FAM13C ^@ http://purl.uniprot.org/uniprot/U3DM92 ^@ Similarity ^@ Belongs to the FAM13 family. http://togogenome.org/gene/9483:ADGRA3 ^@ http://purl.uniprot.org/uniprot/U3E886 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Membrane http://togogenome.org/gene/9483:CYP27B1 ^@ http://purl.uniprot.org/uniprot/F7HIZ6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9483:SF3B3 ^@ http://purl.uniprot.org/uniprot/U3CQS7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:PLK1 ^@ http://purl.uniprot.org/uniprot/F7I711 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.|||Midbody|||Nucleus|||centrosome http://togogenome.org/gene/9483:HNRNPH1 ^@ http://purl.uniprot.org/uniprot/A0A2R8MX49|||http://purl.uniprot.org/uniprot/F7ECV0 ^@ Subcellular Location Annotation ^@ nucleoplasm http://togogenome.org/gene/9483:ZER1 ^@ http://purl.uniprot.org/uniprot/F6VZQ0|||http://purl.uniprot.org/uniprot/U3DDU9 ^@ Similarity ^@ Belongs to the zyg-11 family. http://togogenome.org/gene/9483:LRRC42 ^@ http://purl.uniprot.org/uniprot/F7IF62|||http://purl.uniprot.org/uniprot/F7IMX3 ^@ Similarity ^@ Belongs to the LRRC42 family. http://togogenome.org/gene/9483:MED13 ^@ http://purl.uniprot.org/uniprot/F7HQC9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 13 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9483:ATP1B1 ^@ http://purl.uniprot.org/uniprot/F6THS7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9483:PPIC ^@ http://purl.uniprot.org/uniprot/F7IA22 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9483:RAP2A ^@ http://purl.uniprot.org/uniprot/F6UKW7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Palmitoylated.|||Recycling endosome membrane|||Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. http://togogenome.org/gene/9483:POLD3 ^@ http://purl.uniprot.org/uniprot/F7AUU9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:MC4R ^@ http://purl.uniprot.org/uniprot/A8QXP8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production. Interacts with OPN3; the interaction results in a decrease in MC1R-mediated cAMP signaling and ultimately a decrease in melanin production in melanocytes.|||Membrane|||Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes.|||Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). http://togogenome.org/gene/9483:ADGRF4 ^@ http://purl.uniprot.org/uniprot/F6TPG4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:DYNLT1 ^@ http://purl.uniprot.org/uniprot/F7F2V6 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/9483:CELF6 ^@ http://purl.uniprot.org/uniprot/F6ZUM6|||http://purl.uniprot.org/uniprot/F7ILA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CELF/BRUNOL family.|||Nucleus http://togogenome.org/gene/9483:TMEM39A ^@ http://purl.uniprot.org/uniprot/F6ZMT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM39 family.|||Membrane http://togogenome.org/gene/9483:LOC100405643 ^@ http://purl.uniprot.org/uniprot/F6RXN0 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL11 family.|||Binds directly to 26S ribosomal RNA. http://togogenome.org/gene/9483:IFNW1 ^@ http://purl.uniprot.org/uniprot/A0A7R8C4X6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9483:C4BPB ^@ http://purl.uniprot.org/uniprot/F7BUT1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:PSKH1 ^@ http://purl.uniprot.org/uniprot/F7I5C9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:HCAR1 ^@ http://purl.uniprot.org/uniprot/A0A5F4WJ68 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9483:TSPAN3 ^@ http://purl.uniprot.org/uniprot/U3BKC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9483:CYB5R4 ^@ http://purl.uniprot.org/uniprot/U3BKA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||Endoplasmic reticulum http://togogenome.org/gene/9483:PKNOX2 ^@ http://purl.uniprot.org/uniprot/F6Z692 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/9483:PPIP5K2 ^@ http://purl.uniprot.org/uniprot/U3BTR0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histidine acid phosphatase family. VIP1 subfamily.|||Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).|||cytosol http://togogenome.org/gene/9483:NEDD8 ^@ http://purl.uniprot.org/uniprot/F6S338 ^@ Similarity ^@ Belongs to the ubiquitin family. http://togogenome.org/gene/9483:GCNT4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XJ19|||http://purl.uniprot.org/uniprot/F7IM95 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:GGT5 ^@ http://purl.uniprot.org/uniprot/A0A5K1U0E0 ^@ Similarity ^@ Belongs to the gamma-glutamyltransferase family. http://togogenome.org/gene/9483:XRN2 ^@ http://purl.uniprot.org/uniprot/F6UP03 ^@ Function|||Similarity ^@ Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.|||Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. http://togogenome.org/gene/9483:SUCNR1 ^@ http://purl.uniprot.org/uniprot/A0A5F4W8U5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9483:CDV3 ^@ http://purl.uniprot.org/uniprot/U3B7B9 ^@ Similarity ^@ Belongs to the CDV3 family. http://togogenome.org/gene/9483:TMED3 ^@ http://purl.uniprot.org/uniprot/U3C3B8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9483:DYNLRB2 ^@ http://purl.uniprot.org/uniprot/F6WT84 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.|||Belongs to the GAMAD family.|||Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.|||cytoskeleton http://togogenome.org/gene/9483:MCRIP2 ^@ http://purl.uniprot.org/uniprot/F7BDC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCRIP family.|||Nucleus|||Stress granule http://togogenome.org/gene/9483:HINT2 ^@ http://purl.uniprot.org/uniprot/F7EQY7 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/9483:TPD52L1 ^@ http://purl.uniprot.org/uniprot/F7H5P4|||http://purl.uniprot.org/uniprot/F7HG13|||http://purl.uniprot.org/uniprot/U3DXF7 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/9483:AKR1B1 ^@ http://purl.uniprot.org/uniprot/F7HNF2 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9483:AATF ^@ http://purl.uniprot.org/uniprot/F6V458 ^@ Similarity ^@ Belongs to the AATF family. http://togogenome.org/gene/9483:LRRC8A ^@ http://purl.uniprot.org/uniprot/B0KWE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:NEO1 ^@ http://purl.uniprot.org/uniprot/A0A8I3WAW4|||http://purl.uniprot.org/uniprot/A0A8J8XLN2|||http://purl.uniprot.org/uniprot/A0A8J8Y231|||http://purl.uniprot.org/uniprot/A0A8J8Y270 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. DCC family.|||Membrane http://togogenome.org/gene/9483:OXT ^@ http://purl.uniprot.org/uniprot/G0ZNF4 ^@ Similarity ^@ Belongs to the vasopressin/oxytocin family. http://togogenome.org/gene/9483:NT5C2 ^@ http://purl.uniprot.org/uniprot/U3BF11|||http://purl.uniprot.org/uniprot/U3FJG1 ^@ Cofactor|||Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/9483:TRNT1 ^@ http://purl.uniprot.org/uniprot/U3EM02 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/9483:UPF1 ^@ http://purl.uniprot.org/uniprot/F7HDF7|||http://purl.uniprot.org/uniprot/U3D5B6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA2/NAM7 helicase family.|||Cytoplasm http://togogenome.org/gene/9483:ATP23 ^@ http://purl.uniprot.org/uniprot/F7AHH1 ^@ Similarity ^@ Belongs to the peptidase M76 family. http://togogenome.org/gene/9483:PRKAB1 ^@ http://purl.uniprot.org/uniprot/F7BMG6 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/9483:CDC37L1 ^@ http://purl.uniprot.org/uniprot/U3BUQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC37 family.|||Cytoplasm http://togogenome.org/gene/9483:NIF3L1 ^@ http://purl.uniprot.org/uniprot/F6Z8K6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family.|||Cytoplasm|||Homodimer. Interacts with COPS2. Interacts with THOC7.|||May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.|||Nucleus http://togogenome.org/gene/9483:RPS18 ^@ http://purl.uniprot.org/uniprot/F7I089 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Component of the small ribosomal subunit. http://togogenome.org/gene/9483:COQ5 ^@ http://purl.uniprot.org/uniprot/U3FTS7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).|||Mitochondrion inner membrane http://togogenome.org/gene/9483:CASK ^@ http://purl.uniprot.org/uniprot/A0A2R8MUH7|||http://purl.uniprot.org/uniprot/A0A2R8P5U8|||http://purl.uniprot.org/uniprot/A0A8J8YHG2|||http://purl.uniprot.org/uniprot/U3BRM7|||http://purl.uniprot.org/uniprot/U3CM89|||http://purl.uniprot.org/uniprot/U3DET2|||http://purl.uniprot.org/uniprot/U3EY01 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/9483:IL18R1 ^@ http://purl.uniprot.org/uniprot/F7EMB0 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9483:ADGRG5 ^@ http://purl.uniprot.org/uniprot/A0A8I4A5T1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:PGM2L1 ^@ http://purl.uniprot.org/uniprot/F6UD41 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/9483:ADAMTS5 ^@ http://purl.uniprot.org/uniprot/F6VXD6 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9483:UGCG ^@ http://purl.uniprot.org/uniprot/U3ENT4 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/9483:PSMA5 ^@ http://purl.uniprot.org/uniprot/F7C3R5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9483:UBE2D3 ^@ http://purl.uniprot.org/uniprot/A0A2R8PG33|||http://purl.uniprot.org/uniprot/F6Z536 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9483:NUTF2 ^@ http://purl.uniprot.org/uniprot/F7IRG6 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/9483:COPB2 ^@ http://purl.uniprot.org/uniprot/F6YR44 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat COPB2 family.|||COPI-coated vesicle membrane|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.|||This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner. http://togogenome.org/gene/9483:CXCL2 ^@ http://purl.uniprot.org/uniprot/A0A5F4VXZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9483:GPD1 ^@ http://purl.uniprot.org/uniprot/U3D420 ^@ Similarity ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/9483:PTPN11 ^@ http://purl.uniprot.org/uniprot/F7ICW6|||http://purl.uniprot.org/uniprot/U3C430 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.|||Cytoplasm http://togogenome.org/gene/9483:GALNT17 ^@ http://purl.uniprot.org/uniprot/F7FHV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:SNAPIN ^@ http://purl.uniprot.org/uniprot/F6RYC6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAPIN family.|||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.|||synaptic vesicle membrane http://togogenome.org/gene/9483:LYVE1 ^@ http://purl.uniprot.org/uniprot/A0A5F4W3K1|||http://purl.uniprot.org/uniprot/F7H6X6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:YJU2B ^@ http://purl.uniprot.org/uniprot/F6Z9F1 ^@ Similarity ^@ Belongs to the CWC16 family. http://togogenome.org/gene/9483:RPA1 ^@ http://purl.uniprot.org/uniprot/A0A8I3VV06|||http://purl.uniprot.org/uniprot/U3DXL0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.|||Belongs to the replication factor A protein 1 family.|||Component of the heterotrimeric canonical replication protein A complex (RPA).|||PML body http://togogenome.org/gene/9483:VGLL1 ^@ http://purl.uniprot.org/uniprot/F7F2W1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs.|||Nucleus http://togogenome.org/gene/9483:CSTA ^@ http://purl.uniprot.org/uniprot/F7GIC1 ^@ Similarity ^@ Belongs to the cystatin family. http://togogenome.org/gene/9483:SGTA ^@ http://purl.uniprot.org/uniprot/U3ELV4 ^@ Similarity ^@ Belongs to the SGT family. http://togogenome.org/gene/9483:GSG1L2 ^@ http://purl.uniprot.org/uniprot/F7IFZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSG1 family.|||Membrane http://togogenome.org/gene/9483:CYP20A1 ^@ http://purl.uniprot.org/uniprot/U3ELF2 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9483:TOMM5 ^@ http://purl.uniprot.org/uniprot/F6TDI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom5 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9483:TMEM86A ^@ http://purl.uniprot.org/uniprot/U3FEA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM86 family.|||Membrane http://togogenome.org/gene/9483:TBC1D7 ^@ http://purl.uniprot.org/uniprot/A0A2R8M8P0|||http://purl.uniprot.org/uniprot/F6PP80 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Vesicle http://togogenome.org/gene/9483:CAMLG ^@ http://purl.uniprot.org/uniprot/F7HWS9 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells. http://togogenome.org/gene/9483:ASH2L ^@ http://purl.uniprot.org/uniprot/F6RGV9|||http://purl.uniprot.org/uniprot/U3E6V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Nucleus http://togogenome.org/gene/9483:AGAP2 ^@ http://purl.uniprot.org/uniprot/F6PYY5|||http://purl.uniprot.org/uniprot/F6PZU7 ^@ Similarity ^@ Belongs to the centaurin gamma-like family. http://togogenome.org/gene/9483:SLC26A3 ^@ http://purl.uniprot.org/uniprot/F7BSM6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.|||Membrane http://togogenome.org/gene/9483:SCP2 ^@ http://purl.uniprot.org/uniprot/F7EZA5|||http://purl.uniprot.org/uniprot/U3ATI5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. Thiolase family.|||Cytoplasm|||Interacts with PEX5; the interaction is essential for peroxisomal import.|||Mitochondrion http://togogenome.org/gene/9483:NEFL ^@ http://purl.uniprot.org/uniprot/F6UX82 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9483:MPV17L2 ^@ http://purl.uniprot.org/uniprot/F6X2A6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/9483:SIKE1 ^@ http://purl.uniprot.org/uniprot/U3EVM9 ^@ Similarity ^@ Belongs to the SIKE family. http://togogenome.org/gene/9483:NPY2R ^@ http://purl.uniprot.org/uniprot/F7HQL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:ST6GAL1 ^@ http://purl.uniprot.org/uniprot/F7I274 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9483:GAD2 ^@ http://purl.uniprot.org/uniprot/F7I4W5 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9483:WNT2B ^@ http://purl.uniprot.org/uniprot/A0A2R8MND7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9483:AP3S2 ^@ http://purl.uniprot.org/uniprot/U3FIF5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Membrane|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. http://togogenome.org/gene/9483:SMARCA5 ^@ http://purl.uniprot.org/uniprot/U3FB41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.|||Nucleus http://togogenome.org/gene/9483:RAD23A ^@ http://purl.uniprot.org/uniprot/F7ISE1|||http://purl.uniprot.org/uniprot/F7ISF6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAD23 family.|||Cytoplasm|||Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.|||Nucleus http://togogenome.org/gene/9483:WNT3A ^@ http://purl.uniprot.org/uniprot/A0A5F4W3S5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9483:OGFRL1 ^@ http://purl.uniprot.org/uniprot/F7HBA9|||http://purl.uniprot.org/uniprot/U3EEX7 ^@ Similarity ^@ Belongs to the opioid growth factor receptor family. http://togogenome.org/gene/9483:ATP6V1E2 ^@ http://purl.uniprot.org/uniprot/A0A2R8MGJ7 ^@ Similarity ^@ Belongs to the V-ATPase E subunit family. http://togogenome.org/gene/9483:PPP1R14C ^@ http://purl.uniprot.org/uniprot/F6S3F2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PP1 inhibitor family.|||Inhibitor of PPP1CA.|||Membrane http://togogenome.org/gene/9483:RC3H2 ^@ http://purl.uniprot.org/uniprot/F7BIJ6 ^@ Subcellular Location Annotation ^@ P-body http://togogenome.org/gene/9483:PAGE4 ^@ http://purl.uniprot.org/uniprot/U3CV35 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9483:SYNE3 ^@ http://purl.uniprot.org/uniprot/U3C818 ^@ Similarity ^@ Belongs to the nesprin family. http://togogenome.org/gene/9483:CLDN1 ^@ http://purl.uniprot.org/uniprot/U3BKB1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9483:AMOTL2 ^@ http://purl.uniprot.org/uniprot/U3E3V5 ^@ Similarity ^@ Belongs to the angiomotin family. http://togogenome.org/gene/9483:CEBPE ^@ http://purl.uniprot.org/uniprot/A0A2R8PMY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. C/EBP subfamily.|||Nucleus http://togogenome.org/gene/9483:GPX4 ^@ http://purl.uniprot.org/uniprot/Q32QL6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the glutathione peroxidase family.|||Cytoplasm|||Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (By similarity). Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (By similarity). The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis (By similarity). The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures (By similarity). May be required to protect cells from the toxicity of ingested lipid hydroperoxides (By similarity). Required for normal sperm development and male fertility (By similarity). Essential for maturation and survival of photoreceptor cells (By similarity). Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion (By similarity). Plays a role of glutathione peroxidase in platelets in the arachidonic acid metabolism (By similarity). Reduces hydroperoxy ester lipids formed by a 15-lipoxygenase that may play a role as down-regulator of the cellular 15-lipoxygenase pathway (By similarity).|||Expressed in testis. Also expressed in liver, lung, kidney and spinal cord.|||Mitochondrion|||Monomer. Has a tendency to form higher mass oligomers. http://togogenome.org/gene/9483:KDSR ^@ http://purl.uniprot.org/uniprot/A0A5F4W9Q5|||http://purl.uniprot.org/uniprot/F7H8H1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9483:TIMM10 ^@ http://purl.uniprot.org/uniprot/F6XGD1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9483:SLC7A6 ^@ http://purl.uniprot.org/uniprot/U3FHB9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:GABRB1 ^@ http://purl.uniprot.org/uniprot/U3DHM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9483:LOC100385283 ^@ http://purl.uniprot.org/uniprot/A0A8I3W1K5 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9483:RDH11 ^@ http://purl.uniprot.org/uniprot/U3D6T3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9483:RPL34 ^@ http://purl.uniprot.org/uniprot/F7HLG2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/9483:OSGEP ^@ http://purl.uniprot.org/uniprot/F7IEF6 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:LBX2 ^@ http://purl.uniprot.org/uniprot/A0A2R8M7T5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:PPP1R14D ^@ http://purl.uniprot.org/uniprot/F7ISZ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PP1 inhibitor family.|||Cytoplasm|||Inhibitor of PPP1CA. http://togogenome.org/gene/9483:CBX8 ^@ http://purl.uniprot.org/uniprot/F7F3P9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:ITGB8 ^@ http://purl.uniprot.org/uniprot/A0A8I3WN73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:LMBR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8P8A6|||http://purl.uniprot.org/uniprot/U3ECC1 ^@ Similarity ^@ Belongs to the LIMR family. http://togogenome.org/gene/9483:MEF2C ^@ http://purl.uniprot.org/uniprot/A0A2R8MTX5|||http://purl.uniprot.org/uniprot/F6YQS7|||http://purl.uniprot.org/uniprot/F7E2K3|||http://purl.uniprot.org/uniprot/U3EHQ5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:IGF2BP1 ^@ http://purl.uniprot.org/uniprot/F6X5X9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM IMP/VICKZ family.|||Nucleus|||P-body|||Stress granule|||filopodium|||growth cone|||lamellipodium|||perinuclear region http://togogenome.org/gene/9483:UTP6 ^@ http://purl.uniprot.org/uniprot/A0A8I3WP38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP6 family.|||nucleolus http://togogenome.org/gene/9483:RAB32 ^@ http://purl.uniprot.org/uniprot/F6YNF4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/9483:EIF2S2 ^@ http://purl.uniprot.org/uniprot/F6SFK4 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/9483:S100B ^@ http://purl.uniprot.org/uniprot/F7HBN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the S-100 family.|||Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/9483:MED7 ^@ http://purl.uniprot.org/uniprot/F7FJ65 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 7 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9483:EFNA5 ^@ http://purl.uniprot.org/uniprot/A0A2R8MDR2|||http://purl.uniprot.org/uniprot/U3CAF9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:TMPRSS13 ^@ http://purl.uniprot.org/uniprot/F7H942 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:EFNB2 ^@ http://purl.uniprot.org/uniprot/F7ENK8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:GIPR ^@ http://purl.uniprot.org/uniprot/F6Y4K4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:GADD45A ^@ http://purl.uniprot.org/uniprot/A0A8I3WE50|||http://purl.uniprot.org/uniprot/F7E1K0 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/9483:TSPAN12 ^@ http://purl.uniprot.org/uniprot/U3F063 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9483:MRAP ^@ http://purl.uniprot.org/uniprot/A0A8I3WIB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRAP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:DCTN1 ^@ http://purl.uniprot.org/uniprot/A0A5F4W4E2|||http://purl.uniprot.org/uniprot/F7H677|||http://purl.uniprot.org/uniprot/U3B3Q0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin 150 kDa subunit family.|||Cytoplasm|||cell cortex|||cytoskeleton http://togogenome.org/gene/9483:AZIN1 ^@ http://purl.uniprot.org/uniprot/F6RSV2 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/9483:NR2C2 ^@ http://purl.uniprot.org/uniprot/A0A2R8NC69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9483:RNF4 ^@ http://purl.uniprot.org/uniprot/F7HV40 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:CRELD1 ^@ http://purl.uniprot.org/uniprot/U3CMD9 ^@ Caution|||Similarity ^@ Belongs to the CRELD family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:LOC100897022 ^@ http://purl.uniprot.org/uniprot/U3FCQ0 ^@ Similarity ^@ Belongs to the pro/parathymosin family. http://togogenome.org/gene/9483:SELENBP1 ^@ http://purl.uniprot.org/uniprot/F6VWU2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the selenium-binding protein family.|||Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.|||Interacts with USP33.|||Membrane|||Nucleus|||cytosol http://togogenome.org/gene/9483:RBM47 ^@ http://purl.uniprot.org/uniprot/U3BG53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM RBM47 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:DNAAF4 ^@ http://purl.uniprot.org/uniprot/F6WBM2|||http://purl.uniprot.org/uniprot/U3E2B1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Dynein axonemal particle|||neuron projection http://togogenome.org/gene/9483:PPIL2 ^@ http://purl.uniprot.org/uniprot/U3FA41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.|||Nucleus http://togogenome.org/gene/9483:NDUFAB1 ^@ http://purl.uniprot.org/uniprot/U3AQ14 ^@ Function|||Similarity ^@ Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis. http://togogenome.org/gene/9483:OVOL1 ^@ http://purl.uniprot.org/uniprot/F7F0J6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:APOA1 ^@ http://purl.uniprot.org/uniprot/B0KWR1 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/9483:SMC4 ^@ http://purl.uniprot.org/uniprot/A0A8I3ZZA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family.|||Chromosome|||Nucleus http://togogenome.org/gene/9483:DDX47 ^@ http://purl.uniprot.org/uniprot/U3D605 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily. http://togogenome.org/gene/9483:RBBP4 ^@ http://purl.uniprot.org/uniprot/U3BF00 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:NTMT1 ^@ http://purl.uniprot.org/uniprot/A0A8I4A1R7 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. NTM1 family. http://togogenome.org/gene/9483:HPSE ^@ http://purl.uniprot.org/uniprot/A0A2R8MKT5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 79 family. http://togogenome.org/gene/9483:GOLM1 ^@ http://purl.uniprot.org/uniprot/U3CE44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLM family.|||Membrane http://togogenome.org/gene/9483:CSRNP3 ^@ http://purl.uniprot.org/uniprot/F6PRX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AXUD1 family.|||Nucleus http://togogenome.org/gene/9483:ALDH9A1 ^@ http://purl.uniprot.org/uniprot/U3CQG4 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9483:L3HYPDH ^@ http://purl.uniprot.org/uniprot/F7IKN7 ^@ Similarity ^@ Belongs to the proline racemase family. http://togogenome.org/gene/9483:KIF11 ^@ http://purl.uniprot.org/uniprot/A0A8I3WQI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.|||spindle pole http://togogenome.org/gene/9483:CNDP2 ^@ http://purl.uniprot.org/uniprot/F7HVP6 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20A family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9483:TLCD3B ^@ http://purl.uniprot.org/uniprot/U3ERZ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:RAMP1 ^@ http://purl.uniprot.org/uniprot/F6PYH1 ^@ Similarity ^@ Belongs to the RAMP family. http://togogenome.org/gene/9483:DYDC1 ^@ http://purl.uniprot.org/uniprot/F7HBD3 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/9483:CDH8 ^@ http://purl.uniprot.org/uniprot/U3E3K3 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:UBE2G1 ^@ http://purl.uniprot.org/uniprot/F6RX83 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9483:C1H9orf78 ^@ http://purl.uniprot.org/uniprot/F7CRF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TLS1 family.|||Nucleus http://togogenome.org/gene/9483:CXCL8 ^@ http://purl.uniprot.org/uniprot/A0A8I4A1B7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Homodimer.|||Secreted http://togogenome.org/gene/9483:ING4 ^@ http://purl.uniprot.org/uniprot/F7I4B8|||http://purl.uniprot.org/uniprot/U3BM82|||http://purl.uniprot.org/uniprot/U3CQ34 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9483:POLR3F ^@ http://purl.uniprot.org/uniprot/A0A8I3XE62|||http://purl.uniprot.org/uniprot/F7GCJ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/9483:POPDC2 ^@ http://purl.uniprot.org/uniprot/A0A2R8MF15|||http://purl.uniprot.org/uniprot/U3FG09 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/9483:PTMA ^@ http://purl.uniprot.org/uniprot/A0A8I3WRE3|||http://purl.uniprot.org/uniprot/U3FCQ0 ^@ Similarity ^@ Belongs to the pro/parathymosin family. http://togogenome.org/gene/9483:TMX2 ^@ http://purl.uniprot.org/uniprot/F7H9V7 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain.|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9483:PFN4 ^@ http://purl.uniprot.org/uniprot/F7IBR9 ^@ Similarity ^@ Belongs to the profilin family. http://togogenome.org/gene/9483:RPL8 ^@ http://purl.uniprot.org/uniprot/F7GNR1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/9483:LOC100390342 ^@ http://purl.uniprot.org/uniprot/A0A8I3X0Z4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9483:BMPR1A ^@ http://purl.uniprot.org/uniprot/A0A5K1U8C7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9483:UBE3D ^@ http://purl.uniprot.org/uniprot/U3FPY6 ^@ Function ^@ E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. http://togogenome.org/gene/9483:PRDM1 ^@ http://purl.uniprot.org/uniprot/A0A2R8MN23|||http://purl.uniprot.org/uniprot/A0A5F4WJ23 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily.|||Cytoplasm|||Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.|||Nucleus|||Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions. http://togogenome.org/gene/9483:DAPK3 ^@ http://purl.uniprot.org/uniprot/U3EE09 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:TRIM36 ^@ http://purl.uniprot.org/uniprot/F7GT52 ^@ Subcellular Location Annotation|||Subunit ^@ Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.|||cytoskeleton http://togogenome.org/gene/9483:VAX1 ^@ http://purl.uniprot.org/uniprot/A0A2R8N321 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:BECN1 ^@ http://purl.uniprot.org/uniprot/A0A8I3WGG4|||http://purl.uniprot.org/uniprot/U3BN92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.|||Belongs to the beclin family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Endosome membrane|||Membrane|||Mitochondrion membrane|||Plays a central role in autophagy.|||autophagosome|||trans-Golgi network membrane http://togogenome.org/gene/9483:WDR83OS ^@ http://purl.uniprot.org/uniprot/F7EUK6 ^@ Similarity ^@ Belongs to the Asterix family. http://togogenome.org/gene/9483:UTP18 ^@ http://purl.uniprot.org/uniprot/A0A8J8XTK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat UTP18 family.|||nucleolus http://togogenome.org/gene/9483:EMC3 ^@ http://purl.uniprot.org/uniprot/F7I2L0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC3 family.|||Component of the ER membrane protein complex (EMC).|||Membrane http://togogenome.org/gene/9483:MMUT ^@ http://purl.uniprot.org/uniprot/A0A2R8MCH4 ^@ Function|||Similarity ^@ Belongs to the methylmalonyl-CoA mutase family.|||Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle. http://togogenome.org/gene/9483:TMTC4 ^@ http://purl.uniprot.org/uniprot/A0A8I3VYA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/9483:IL7R ^@ http://purl.uniprot.org/uniprot/A5HJM1 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 4 subfamily.|||Cell membrane|||N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form.|||Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP) (By similarity).|||The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R (By similarity).|||The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.|||The box 1 motif is required for JAK interaction and/or activation. http://togogenome.org/gene/9483:TMEM9B ^@ http://purl.uniprot.org/uniprot/F6RAC2 ^@ Similarity ^@ Belongs to the TMEM9 family. http://togogenome.org/gene/9483:KIZ ^@ http://purl.uniprot.org/uniprot/U3B928 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the kizuna family.|||Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.|||centrosome|||cilium basal body http://togogenome.org/gene/9483:TIGD1 ^@ http://purl.uniprot.org/uniprot/F6SUC8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:TAF1B ^@ http://purl.uniprot.org/uniprot/F7D4T5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRN7/TAF1B family.|||Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.|||nucleolus http://togogenome.org/gene/9483:PCMT1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XFP4 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/9483:GPR37L1 ^@ http://purl.uniprot.org/uniprot/F7D1B0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9483:WDR48 ^@ http://purl.uniprot.org/uniprot/F7GA04|||http://purl.uniprot.org/uniprot/F7GRJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR48 family.|||Late endosome http://togogenome.org/gene/9483:MRPS18A ^@ http://purl.uniprot.org/uniprot/U3CCR0 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9483:PDLIM3 ^@ http://purl.uniprot.org/uniprot/A0A8I3WPM0|||http://purl.uniprot.org/uniprot/F7IKP8 ^@ Subcellular Location Annotation ^@ Z line http://togogenome.org/gene/9483:COA5 ^@ http://purl.uniprot.org/uniprot/A0A8I4A0R0 ^@ Function|||Similarity ^@ Belongs to the PET191 family.|||Involved in an early step of the mitochondrial complex IV assembly process. http://togogenome.org/gene/9483:LMNB1 ^@ http://purl.uniprot.org/uniprot/F7EH81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intermediate filament family.|||Nucleus lamina http://togogenome.org/gene/9483:SSBP2 ^@ http://purl.uniprot.org/uniprot/A0A8I3W1R4|||http://purl.uniprot.org/uniprot/F7FQL7|||http://purl.uniprot.org/uniprot/U3DVE1|||http://purl.uniprot.org/uniprot/U3EGN9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:HSBP1L1 ^@ http://purl.uniprot.org/uniprot/F7H0N8 ^@ Similarity ^@ Belongs to the HSBP1 family. http://togogenome.org/gene/9483:STIM2 ^@ http://purl.uniprot.org/uniprot/A0A5F4WLF5|||http://purl.uniprot.org/uniprot/F7EAG6|||http://purl.uniprot.org/uniprot/F7EAI3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:TADA1 ^@ http://purl.uniprot.org/uniprot/U3EKL8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TADA1 family.|||Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.|||Nucleus|||Probably involved in transcriptional regulation. http://togogenome.org/gene/9483:TBC1D31 ^@ http://purl.uniprot.org/uniprot/A0A5K1UFN6|||http://purl.uniprot.org/uniprot/F7BFT0 ^@ Function|||Subcellular Location Annotation ^@ Molecular adapter which is involved in cilium biogenesis. Part of a functional complex including OFD1 a centriolar protein involved in cilium assembly. Could regulate the cAMP-dependent phosphorylation of OFD1, and its subsequent ubiquitination by PJA2 which ultimately leads to its proteasomal degradation.|||centriolar satellite|||cilium basal body http://togogenome.org/gene/9483:ALG5 ^@ http://purl.uniprot.org/uniprot/A0A8I3WIV8|||http://purl.uniprot.org/uniprot/A0A8I3WLK3 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/9483:STRIP1 ^@ http://purl.uniprot.org/uniprot/F7FY24 ^@ Similarity ^@ Belongs to the STRIP family. http://togogenome.org/gene/9483:UGT8 ^@ http://purl.uniprot.org/uniprot/F7F597|||http://purl.uniprot.org/uniprot/U3CT46 ^@ Similarity ^@ Belongs to the UDP-glycosyltransferase family. http://togogenome.org/gene/9483:VIP ^@ http://purl.uniprot.org/uniprot/F7ID94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/9483:PDE6D ^@ http://purl.uniprot.org/uniprot/A0A2R8MZS4|||http://purl.uniprot.org/uniprot/U3F978 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PDE6D/unc-119 family.|||Cytoplasmic vesicle membrane|||Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains and two inhibitory chains; has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane.|||Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.|||cilium basal body|||cytosol http://togogenome.org/gene/9483:SPEM2 ^@ http://purl.uniprot.org/uniprot/F6VSK4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:ACTRT2 ^@ http://purl.uniprot.org/uniprot/A0A2R8P9Q1 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9483:CDC45 ^@ http://purl.uniprot.org/uniprot/F7IIN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC45 family.|||Nucleus http://togogenome.org/gene/9483:LOC100398394 ^@ http://purl.uniprot.org/uniprot/F6Q3N9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/9483:BMP10 ^@ http://purl.uniprot.org/uniprot/F7IKG6 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9483:SLC13A3 ^@ http://purl.uniprot.org/uniprot/U3F1K1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/9483:RACK1 ^@ http://purl.uniprot.org/uniprot/F7ICV3 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily. http://togogenome.org/gene/9483:CDCA8 ^@ http://purl.uniprot.org/uniprot/F7H9W3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the borealin family.|||centromere http://togogenome.org/gene/9483:GNB5 ^@ http://purl.uniprot.org/uniprot/U3D678 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/9483:LOC100401791 ^@ http://purl.uniprot.org/uniprot/A0A8I3VXS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:HIGD1A ^@ http://purl.uniprot.org/uniprot/A0A8I3WK81 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/9483:LOC100401281 ^@ http://purl.uniprot.org/uniprot/F7A3K0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 5A family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:GJB5 ^@ http://purl.uniprot.org/uniprot/F7I2A7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9483:GPHN ^@ http://purl.uniprot.org/uniprot/A0A8I3WEH8|||http://purl.uniprot.org/uniprot/A0A8I3WIT4|||http://purl.uniprot.org/uniprot/U3CGY7|||http://purl.uniprot.org/uniprot/U3FKH4 ^@ Function|||Similarity ^@ Belongs to the MoeA family.|||Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.|||In the C-terminal section; belongs to the MoeA family.|||In the N-terminal section; belongs to the MoaB/Mog family. http://togogenome.org/gene/9483:MAN1A2 ^@ http://purl.uniprot.org/uniprot/U3FXH5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9483:PLPBP ^@ http://purl.uniprot.org/uniprot/F7I3A2 ^@ Function|||Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.|||Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6. http://togogenome.org/gene/9483:PLEKHA8 ^@ http://purl.uniprot.org/uniprot/A0A8I4A4K9|||http://purl.uniprot.org/uniprot/U3DPZ8 ^@ Subcellular Location Annotation ^@ trans-Golgi network membrane http://togogenome.org/gene/9483:ASPN ^@ http://purl.uniprot.org/uniprot/F7ILC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||extracellular matrix http://togogenome.org/gene/9483:GPR158 ^@ http://purl.uniprot.org/uniprot/F7HR18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9483:CELSR2 ^@ http://purl.uniprot.org/uniprot/U3FXU3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor that may have an important role in cell/cell signaling during nervous system formation. http://togogenome.org/gene/9483:LOC100410514 ^@ http://purl.uniprot.org/uniprot/A0A8I3W3G2 ^@ Function|||Subcellular Location Annotation ^@ Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/9483:LOC100407794 ^@ http://purl.uniprot.org/uniprot/A0A2R8NDJ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCR10/QCR9 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9483:TRAPPC2L ^@ http://purl.uniprot.org/uniprot/U3FMB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||perinuclear region http://togogenome.org/gene/9483:TEF ^@ http://purl.uniprot.org/uniprot/F7HNV2|||http://purl.uniprot.org/uniprot/F7I370|||http://purl.uniprot.org/uniprot/U3FVL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/9483:ODC1 ^@ http://purl.uniprot.org/uniprot/F7GMF7 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/9483:SND1 ^@ http://purl.uniprot.org/uniprot/U3BQS3 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. http://togogenome.org/gene/9483:SLC6A14 ^@ http://purl.uniprot.org/uniprot/F7BP63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9483:PHYKPL ^@ http://purl.uniprot.org/uniprot/U3BHS3 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9483:USO1 ^@ http://purl.uniprot.org/uniprot/A0A2R8MUA2|||http://purl.uniprot.org/uniprot/U3ETI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VDP/USO1/EDE1 family.|||Membrane http://togogenome.org/gene/9483:EML4 ^@ http://purl.uniprot.org/uniprot/F7E9Y2|||http://purl.uniprot.org/uniprot/F7GPN0 ^@ Similarity ^@ Belongs to the WD repeat EMAP family. http://togogenome.org/gene/9483:LOC100406157 ^@ http://purl.uniprot.org/uniprot/U3FTR3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:EVX1 ^@ http://purl.uniprot.org/uniprot/B0VXL0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:PRKCD ^@ http://purl.uniprot.org/uniprot/F6ZHC0 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression.|||Cytoplasm|||Interacts with PDPK1 (via N-terminal region), RAD9A, CDCP1, MUC1 and VASP.|||Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.|||Nucleus|||perinuclear region http://togogenome.org/gene/9483:PPFIA1 ^@ http://purl.uniprot.org/uniprot/A0A8I3X0S7|||http://purl.uniprot.org/uniprot/U3BNY6 ^@ Similarity ^@ Belongs to the liprin family. Liprin-alpha subfamily. http://togogenome.org/gene/9483:DOK6 ^@ http://purl.uniprot.org/uniprot/F7ILS8 ^@ Similarity ^@ Belongs to the DOK family. Type B subfamily. http://togogenome.org/gene/9483:PSMA3 ^@ http://purl.uniprot.org/uniprot/F7IS34 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9483:C14H2orf49 ^@ http://purl.uniprot.org/uniprot/F7IST7|||http://purl.uniprot.org/uniprot/U3D1E7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ashwin family.|||Nucleus http://togogenome.org/gene/9483:MCU ^@ http://purl.uniprot.org/uniprot/F6WI22 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MCU (TC 1.A.77) family.|||Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region: while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core. The inner core is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH).|||Membrane|||Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:ACVR1C ^@ http://purl.uniprot.org/uniprot/F7H6A3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9483:RRAGD ^@ http://purl.uniprot.org/uniprot/F6VSE7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/9483:SOX11 ^@ http://purl.uniprot.org/uniprot/A0A2R8MWJ4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:FAM241B ^@ http://purl.uniprot.org/uniprot/F6XHS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM241 family.|||Membrane http://togogenome.org/gene/9483:OR5D18 ^@ http://purl.uniprot.org/uniprot/A0A2R8MSW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:YWHAG ^@ http://purl.uniprot.org/uniprot/F7DNK1 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9483:C9H12orf57 ^@ http://purl.uniprot.org/uniprot/U3BEU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0456 family.|||Cytoplasm http://togogenome.org/gene/9483:DEFB126 ^@ http://purl.uniprot.org/uniprot/A0A8I3WMU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9483:IPO7 ^@ http://purl.uniprot.org/uniprot/F6PKJ8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:STAMBP ^@ http://purl.uniprot.org/uniprot/U3D897 ^@ Similarity ^@ Belongs to the peptidase M67C family. http://togogenome.org/gene/9483:NT5DC1 ^@ http://purl.uniprot.org/uniprot/A0A2R8N7M8 ^@ Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family. http://togogenome.org/gene/9483:DHX15 ^@ http://purl.uniprot.org/uniprot/F7HGM8 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily. http://togogenome.org/gene/9483:THNSL1 ^@ http://purl.uniprot.org/uniprot/F7HKB5 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/9483:ATP5MC1 ^@ http://purl.uniprot.org/uniprot/A0A5F4VT63|||http://purl.uniprot.org/uniprot/A0A8I3VYN5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/9483:ARHGEF3 ^@ http://purl.uniprot.org/uniprot/A0A5K1VRD5|||http://purl.uniprot.org/uniprot/F7FYU0|||http://purl.uniprot.org/uniprot/F7GL31 ^@ Function|||Subcellular Location Annotation ^@ Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.|||Cytoplasm http://togogenome.org/gene/9483:SAP130 ^@ http://purl.uniprot.org/uniprot/A0A8I3WIR2|||http://purl.uniprot.org/uniprot/F7E211 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAP130 family.|||Nucleus http://togogenome.org/gene/9483:RDH14 ^@ http://purl.uniprot.org/uniprot/F7AE01 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9483:EXO5 ^@ http://purl.uniprot.org/uniprot/F6TP17 ^@ Similarity ^@ Belongs to the EXO5 family. http://togogenome.org/gene/9483:CLCN6 ^@ http://purl.uniprot.org/uniprot/F6YJI7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:SMIM8 ^@ http://purl.uniprot.org/uniprot/A0A8I3X399 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM8 family.|||Membrane http://togogenome.org/gene/9483:STEAP2 ^@ http://purl.uniprot.org/uniprot/B0VXE5|||http://purl.uniprot.org/uniprot/U3D7S2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9483:DENND6A ^@ http://purl.uniprot.org/uniprot/U3BSL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DENND6 family.|||Recycling endosome http://togogenome.org/gene/9483:GNAI2 ^@ http://purl.uniprot.org/uniprot/F6ZZK3 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9483:RDH10 ^@ http://purl.uniprot.org/uniprot/U3DMT3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9483:TMEM263 ^@ http://purl.uniprot.org/uniprot/F7GTZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM263 family.|||Membrane http://togogenome.org/gene/9483:IL36RN ^@ http://purl.uniprot.org/uniprot/F6VYZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9483:LOC100407433 ^@ http://purl.uniprot.org/uniprot/F6RAS1 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9483:TCTN1 ^@ http://purl.uniprot.org/uniprot/U3F6Q5 ^@ Similarity|||Subunit ^@ Belongs to the tectonic family.|||Part of the tectonic-like complex (also named B9 complex). http://togogenome.org/gene/9483:EVX2 ^@ http://purl.uniprot.org/uniprot/A0A8I3W8Y3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:GJB1 ^@ http://purl.uniprot.org/uniprot/F6RE67 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins. Interacts with CNST.|||Belongs to the connexin family. Beta-type (group I) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9483:STK3 ^@ http://purl.uniprot.org/uniprot/U3DWY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Nucleus http://togogenome.org/gene/9483:IGF1 ^@ http://purl.uniprot.org/uniprot/A0A2R8PMZ8|||http://purl.uniprot.org/uniprot/U3D2G5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/9483:ABCA4 ^@ http://purl.uniprot.org/uniprot/F6R1N0 ^@ Subcellular Location Annotation|||Subunit ^@ Membrane|||Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and NHERF1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through NHERF1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation. http://togogenome.org/gene/9483:LOC100392652 ^@ http://purl.uniprot.org/uniprot/F7FFB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:SLC28A3 ^@ http://purl.uniprot.org/uniprot/F6TSP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Membrane http://togogenome.org/gene/9483:TNFAIP1 ^@ http://purl.uniprot.org/uniprot/F7I5U0 ^@ Similarity ^@ Belongs to the BACURD family. http://togogenome.org/gene/9483:PALS2 ^@ http://purl.uniprot.org/uniprot/F6ZVZ4|||http://purl.uniprot.org/uniprot/U3DTF2 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/9483:LOC100403489 ^@ http://purl.uniprot.org/uniprot/A0A8I3XA83 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9483:LOC103787206 ^@ http://purl.uniprot.org/uniprot/U3DJ48 ^@ Similarity ^@ Belongs to the pleiotrophin family. http://togogenome.org/gene/9483:PIGP ^@ http://purl.uniprot.org/uniprot/F6WQP5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGP family.|||Membrane|||Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. http://togogenome.org/gene/9483:SLC27A2 ^@ http://purl.uniprot.org/uniprot/F7ISY6 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9483:TUBD1 ^@ http://purl.uniprot.org/uniprot/U3CA49|||http://purl.uniprot.org/uniprot/U3FMD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin family.|||Nucleus|||centriole|||cilium http://togogenome.org/gene/9483:ALKBH6 ^@ http://purl.uniprot.org/uniprot/U3FY57 ^@ Similarity ^@ Belongs to the alkB family. http://togogenome.org/gene/9483:FAM241A ^@ http://purl.uniprot.org/uniprot/F7H5J5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM241 family.|||Membrane http://togogenome.org/gene/9483:OSBPL2 ^@ http://purl.uniprot.org/uniprot/F7IE45 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9483:SLC25A37 ^@ http://purl.uniprot.org/uniprot/U3C4C8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9483:LOC100409675 ^@ http://purl.uniprot.org/uniprot/A0A8I4A3H8 ^@ Similarity ^@ Belongs to the cytochrome c oxidase VIIa family. http://togogenome.org/gene/9483:MS4A1 ^@ http://purl.uniprot.org/uniprot/Q3LRP2 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9483:ITGA8 ^@ http://purl.uniprot.org/uniprot/F7ALM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9483:CWC25 ^@ http://purl.uniprot.org/uniprot/U3EAP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CWC25 family.|||Nucleus http://togogenome.org/gene/9483:GAR1 ^@ http://purl.uniprot.org/uniprot/U3B6I4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GAR1 family.|||Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).|||Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.|||nucleolus http://togogenome.org/gene/9483:CDC42BPA ^@ http://purl.uniprot.org/uniprot/U3EZV2|||http://purl.uniprot.org/uniprot/U3F4D3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.|||Cytoplasm|||lamellipodium http://togogenome.org/gene/9483:STX7 ^@ http://purl.uniprot.org/uniprot/B0KWA3 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9483:CERS6 ^@ http://purl.uniprot.org/uniprot/F7I442|||http://purl.uniprot.org/uniprot/F7I6G2 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9483:ETFDH ^@ http://purl.uniprot.org/uniprot/A0A5F4WDT9 ^@ Cofactor|||Function ^@ Accepts electrons from ETF and reduces ubiquinone.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/9483:VOPP1 ^@ http://purl.uniprot.org/uniprot/U3BC45 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VOPP1/ECOP family.|||Cytoplasmic vesicle membrane|||Endosome membrane|||Interacts with WWOX (via WW domain).|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9483:CTPS2 ^@ http://purl.uniprot.org/uniprot/A0A5F4W4V1|||http://purl.uniprot.org/uniprot/A0A5F4WL23|||http://purl.uniprot.org/uniprot/F7CKK2 ^@ Function|||Similarity ^@ Belongs to the CTP synthase family.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. http://togogenome.org/gene/9483:LSM2 ^@ http://purl.uniprot.org/uniprot/F7C2X5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||Nucleus http://togogenome.org/gene/9483:TFCP2 ^@ http://purl.uniprot.org/uniprot/U3EZM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus http://togogenome.org/gene/9483:ZKSCAN1 ^@ http://purl.uniprot.org/uniprot/F6W5I1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:GALT ^@ http://purl.uniprot.org/uniprot/F6VPS6 ^@ Cofactor|||Similarity ^@ Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.|||Binds 1 Fe cation per subunit. http://togogenome.org/gene/9483:ZDHHC22 ^@ http://purl.uniprot.org/uniprot/F6Y2X5 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9483:NAGK ^@ http://purl.uniprot.org/uniprot/A0A8I3WTA6 ^@ Similarity ^@ Belongs to the eukaryotic-type N-acetylglucosamine kinase family. http://togogenome.org/gene/9483:MARK4 ^@ http://purl.uniprot.org/uniprot/U3BWG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||dendrite http://togogenome.org/gene/9483:TNFAIP3 ^@ http://purl.uniprot.org/uniprot/F7I413 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9483:SKAP2 ^@ http://purl.uniprot.org/uniprot/A0A8I3WDR4 ^@ Similarity ^@ Belongs to the SKAP family. http://togogenome.org/gene/9483:TWF1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XM35|||http://purl.uniprot.org/uniprot/A0A8J8XXN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.|||cytoskeleton http://togogenome.org/gene/9483:TNS3 ^@ http://purl.uniprot.org/uniprot/U3C992 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTEN phosphatase protein family.|||focal adhesion http://togogenome.org/gene/9483:GINS2 ^@ http://purl.uniprot.org/uniprot/F7IEQ4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS2/PSF2 family.|||Chromosome|||Component of the GINS complex.|||Nucleus http://togogenome.org/gene/9483:THOC7 ^@ http://purl.uniprot.org/uniprot/A0A5F4W1V2|||http://purl.uniprot.org/uniprot/U3EI93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the THOC7 family.|||Nucleus|||Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. http://togogenome.org/gene/9483:SLC9A1 ^@ http://purl.uniprot.org/uniprot/F6ZMV1 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9483:EIF4EBP2 ^@ http://purl.uniprot.org/uniprot/F7I0B2 ^@ Similarity ^@ Belongs to the eIF4E-binding protein family. http://togogenome.org/gene/9483:LOC100399796 ^@ http://purl.uniprot.org/uniprot/A0A2R8MMI8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9483:UBE2F ^@ http://purl.uniprot.org/uniprot/F7E5F0|||http://purl.uniprot.org/uniprot/F7IDH7 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9483:LOC100404354 ^@ http://purl.uniprot.org/uniprot/A0A8I3WBI1|||http://purl.uniprot.org/uniprot/F7INF4 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/9483:MYSM1 ^@ http://purl.uniprot.org/uniprot/U3D192 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M67A family. MYSM1 subfamily.|||Nucleus http://togogenome.org/gene/9483:SNRPD3 ^@ http://purl.uniprot.org/uniprot/F7HY39 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.|||cytosol http://togogenome.org/gene/9483:ANAPC10 ^@ http://purl.uniprot.org/uniprot/F6YKH3 ^@ Function|||Similarity ^@ Belongs to the APC10 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. http://togogenome.org/gene/9483:AQR ^@ http://purl.uniprot.org/uniprot/U3EN21 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CWF11 family.|||Identified in the spliceosome C complex. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE.|||Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.|||Nucleus http://togogenome.org/gene/9483:EXOC8 ^@ http://purl.uniprot.org/uniprot/U3AW65 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EXO84 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.|||growth cone|||perinuclear region http://togogenome.org/gene/9483:FBXO46 ^@ http://purl.uniprot.org/uniprot/U3FLG3 ^@ Function ^@ Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. http://togogenome.org/gene/9483:RNPC3 ^@ http://purl.uniprot.org/uniprot/F7CKT0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Found in a complex with m(7)G-capped U12 snRNA. Interacts with PDCD7.|||Nucleus|||Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA. http://togogenome.org/gene/9483:CHAF1A ^@ http://purl.uniprot.org/uniprot/U3BQH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CHAF1A family.|||Nucleus http://togogenome.org/gene/9483:ZSCAN31 ^@ http://purl.uniprot.org/uniprot/F7HWM1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:PDE7B ^@ http://purl.uniprot.org/uniprot/A0A2R8MIN9|||http://purl.uniprot.org/uniprot/F7DVY7 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9483:CNR1 ^@ http://purl.uniprot.org/uniprot/F7CF55 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG). Signaling typically involves reduction in cyclic AMP.|||Interacts (via C-terminus) with CNRIP1.|||Membrane|||Mitochondrion outer membrane|||Presynapse|||Synapse|||axon http://togogenome.org/gene/9483:APOC1 ^@ http://purl.uniprot.org/uniprot/A0A8I3WXK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the apolipoprotein C1 family.|||Secreted http://togogenome.org/gene/9483:SLC7A8 ^@ http://purl.uniprot.org/uniprot/A0A8I3W8P1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:SGSH ^@ http://purl.uniprot.org/uniprot/F7DJR5 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9483:FGD6 ^@ http://purl.uniprot.org/uniprot/U3DL37 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9483:TUBGCP4 ^@ http://purl.uniprot.org/uniprot/A0A8I4A2B3|||http://purl.uniprot.org/uniprot/F7HYF3|||http://purl.uniprot.org/uniprot/U3BHN7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.|||centrosome http://togogenome.org/gene/9483:STRADB ^@ http://purl.uniprot.org/uniprot/A0A2R8ME70 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. http://togogenome.org/gene/9483:PARP11 ^@ http://purl.uniprot.org/uniprot/F7IBI0|||http://purl.uniprot.org/uniprot/U3C7G5 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9483:GSK3B ^@ http://purl.uniprot.org/uniprot/A0A2R8M2M3|||http://purl.uniprot.org/uniprot/A0A2R8M2U0|||http://purl.uniprot.org/uniprot/F6V0J0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. http://togogenome.org/gene/9483:RDH8 ^@ http://purl.uniprot.org/uniprot/F7IKQ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Membrane|||Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity. http://togogenome.org/gene/9483:CSNK2A2 ^@ http://purl.uniprot.org/uniprot/F6R0E2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:HMOX1 ^@ http://purl.uniprot.org/uniprot/U3B7F4 ^@ Similarity ^@ Belongs to the heme oxygenase family. http://togogenome.org/gene/9483:LOC100406879 ^@ http://purl.uniprot.org/uniprot/A0A8I4A3R5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:YPEL5 ^@ http://purl.uniprot.org/uniprot/F7HRG9 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9483:TRAF6 ^@ http://purl.uniprot.org/uniprot/F7ES31|||http://purl.uniprot.org/uniprot/U3DER5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family. A subfamily.|||Lipid droplet|||Nucleus|||cell cortex http://togogenome.org/gene/9483:P2RY13 ^@ http://purl.uniprot.org/uniprot/F6XPZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:TBC1D23 ^@ http://purl.uniprot.org/uniprot/F7B3B4|||http://purl.uniprot.org/uniprot/U3BR58 ^@ Subcellular Location Annotation ^@ trans-Golgi network http://togogenome.org/gene/9483:UBE2D1 ^@ http://purl.uniprot.org/uniprot/A0A2R8MUS0|||http://purl.uniprot.org/uniprot/F6QMS1 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9483:RGS14 ^@ http://purl.uniprot.org/uniprot/U3BVC0 ^@ Subcellular Location Annotation ^@ dendrite http://togogenome.org/gene/9483:MAP3K9 ^@ http://purl.uniprot.org/uniprot/F7GPM0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/9483:DNAAF6 ^@ http://purl.uniprot.org/uniprot/F7GS79 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/9483:COPG2 ^@ http://purl.uniprot.org/uniprot/U3CBT2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPG family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/9483:CC2D1B ^@ http://purl.uniprot.org/uniprot/U3BD00|||http://purl.uniprot.org/uniprot/U3D670 ^@ Similarity ^@ Belongs to the CC2D1 family. http://togogenome.org/gene/9483:CACFD1 ^@ http://purl.uniprot.org/uniprot/F7H4B8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel flower family.|||Membrane http://togogenome.org/gene/9483:MTHFD1 ^@ http://purl.uniprot.org/uniprot/U3FKL3 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.|||In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. http://togogenome.org/gene/9483:NEK8 ^@ http://purl.uniprot.org/uniprot/A0A8I3WJ52|||http://purl.uniprot.org/uniprot/F7D996 ^@ Similarity ^@ Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. http://togogenome.org/gene/9483:DEFB108B ^@ http://purl.uniprot.org/uniprot/F6RM81 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9483:CPNE9 ^@ http://purl.uniprot.org/uniprot/F7I7P4 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9483:PJVK ^@ http://purl.uniprot.org/uniprot/F7IH02 ^@ Similarity ^@ Belongs to the gasdermin family. http://togogenome.org/gene/9483:ISL2 ^@ http://purl.uniprot.org/uniprot/F7DL07 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:CFB ^@ http://purl.uniprot.org/uniprot/F7AP80|||http://purl.uniprot.org/uniprot/U3FAF5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9483:EMC6 ^@ http://purl.uniprot.org/uniprot/F6X896 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC6 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:SMG1 ^@ http://purl.uniprot.org/uniprot/F6S837 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. http://togogenome.org/gene/9483:CCDC172 ^@ http://purl.uniprot.org/uniprot/F7GTK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC172 family.|||Cytoplasm http://togogenome.org/gene/9483:RAB39A ^@ http://purl.uniprot.org/uniprot/F7G8P2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:SLC2A2 ^@ http://purl.uniprot.org/uniprot/F7AN96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:CKS1B ^@ http://purl.uniprot.org/uniprot/F7IM94 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.|||Forms a homohexamer that can probably bind six kinase subunits. http://togogenome.org/gene/9483:FSCN1 ^@ http://purl.uniprot.org/uniprot/U3EU72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fascin family.|||cytoskeleton http://togogenome.org/gene/9483:FAM161A ^@ http://purl.uniprot.org/uniprot/A0A8J8Y4H3|||http://purl.uniprot.org/uniprot/F6YP42 ^@ Similarity ^@ Belongs to the FAM161 family. http://togogenome.org/gene/9483:ASZ1 ^@ http://purl.uniprot.org/uniprot/Q2QLG0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.|||Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity). http://togogenome.org/gene/9483:RPS13 ^@ http://purl.uniprot.org/uniprot/F7IH12 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/9483:DKK4 ^@ http://purl.uniprot.org/uniprot/F7IIK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/9483:CASD1 ^@ http://purl.uniprot.org/uniprot/A0A8I4A1B6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PC-esterase family. CASD1 subfamily.|||Membrane http://togogenome.org/gene/9483:ESX1 ^@ http://purl.uniprot.org/uniprot/F7GUU9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:TMEM237 ^@ http://purl.uniprot.org/uniprot/U3DWS8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM237 family.|||Component of the transition zone in primary cilia. Required for ciliogenesis.|||Membrane|||cilium http://togogenome.org/gene/9483:SLC25A20 ^@ http://purl.uniprot.org/uniprot/F6ZL48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9483:PSMC3 ^@ http://purl.uniprot.org/uniprot/U3E6L1 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9483:TRIM21 ^@ http://purl.uniprot.org/uniprot/F7ALH2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRIM/RBCC family.|||Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:PABPC1 ^@ http://purl.uniprot.org/uniprot/F7I5L7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyadenylate-binding protein type-1 family.|||Binds the poly(A) tail of mRNA.|||Cytoplasm http://togogenome.org/gene/9483:HP ^@ http://purl.uniprot.org/uniprot/U3D531 ^@ Caution|||Function|||Similarity|||Subunit ^@ As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.|||Belongs to the peptidase S1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Tetramer of two alpha and two beta chains; disulfide-linked (By similarity). The hemoglobin/haptoglobin complex is composed of a haptoglobin dimer bound to two hemoglobin alpha-beta dimers (By similarity). Interacts with CD163 (By similarity). Interacts with ERGIC3. http://togogenome.org/gene/9483:PON3 ^@ http://purl.uniprot.org/uniprot/U3DKS0 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit.|||Glycosylated. http://togogenome.org/gene/9483:SHROOM3 ^@ http://purl.uniprot.org/uniprot/A0A8I3WDK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shroom family.|||cytoskeleton http://togogenome.org/gene/9483:CDH24 ^@ http://purl.uniprot.org/uniprot/F7DFL0 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:UPF2 ^@ http://purl.uniprot.org/uniprot/F7INJ8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:REEP5 ^@ http://purl.uniprot.org/uniprot/U3FI78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/9483:EPHA5 ^@ http://purl.uniprot.org/uniprot/A0A5F4W3L2|||http://purl.uniprot.org/uniprot/F7ITC6|||http://purl.uniprot.org/uniprot/U3ENY5|||http://purl.uniprot.org/uniprot/U3EYB4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:SFXN4 ^@ http://purl.uniprot.org/uniprot/F7H4D5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Membrane http://togogenome.org/gene/9483:SEMA7A ^@ http://purl.uniprot.org/uniprot/U3NLN1 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:CNTF ^@ http://purl.uniprot.org/uniprot/U3EDL2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNTF family.|||CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.|||Cytoplasm http://togogenome.org/gene/9483:RRAD ^@ http://purl.uniprot.org/uniprot/F6VQZ9 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/9483:AUH ^@ http://purl.uniprot.org/uniprot/F7ISC3 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9483:NUDT2 ^@ http://purl.uniprot.org/uniprot/F7E8D9 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/9483:PPP2R5D ^@ http://purl.uniprot.org/uniprot/A0A2R8MHR3 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9483:CLRN2 ^@ http://purl.uniprot.org/uniprot/F7IQE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/9483:ECHDC1 ^@ http://purl.uniprot.org/uniprot/A0A2R8MQZ9 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9483:XPO1 ^@ http://purl.uniprot.org/uniprot/A0A8I3WWM2|||http://purl.uniprot.org/uniprot/U3DD16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm http://togogenome.org/gene/9483:RAP2B ^@ http://purl.uniprot.org/uniprot/F7IBL9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Palmitoylated.|||Recycling endosome membrane|||Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. http://togogenome.org/gene/9483:GTF2B ^@ http://purl.uniprot.org/uniprot/A0A8I3ZYT9|||http://purl.uniprot.org/uniprot/U3EF86 ^@ Similarity ^@ Belongs to the TFIIB family. http://togogenome.org/gene/9483:KCNG3 ^@ http://purl.uniprot.org/uniprot/F7FFQ3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9483:IL20 ^@ http://purl.uniprot.org/uniprot/F6WZC9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/9483:BMX ^@ http://purl.uniprot.org/uniprot/F7A015 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cytoplasm http://togogenome.org/gene/9483:PMM2 ^@ http://purl.uniprot.org/uniprot/A0A8I3WEB1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic PMM family.|||Cytoplasm|||Homodimer.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/9483:TAFA2 ^@ http://purl.uniprot.org/uniprot/F7DMM8 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/9483:HSPH1 ^@ http://purl.uniprot.org/uniprot/F7HN07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 70 family.|||Cytoplasm http://togogenome.org/gene/9483:IKBKB ^@ http://purl.uniprot.org/uniprot/F7IBM5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9483:TEKT2 ^@ http://purl.uniprot.org/uniprot/F7G6Y1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/9483:CDC42EP2 ^@ http://purl.uniprot.org/uniprot/F7I5F3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system|||Probably involved in the organization of the actin cytoskeleton.|||cytoskeleton http://togogenome.org/gene/9483:LDLR ^@ http://purl.uniprot.org/uniprot/U3DIM9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:PRPH2 ^@ http://purl.uniprot.org/uniprot/F7HZ28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRPH2/ROM1 family.|||Membrane http://togogenome.org/gene/9483:SPTLC3 ^@ http://purl.uniprot.org/uniprot/F7ARU6 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9483:SLC25A32 ^@ http://purl.uniprot.org/uniprot/F7I546 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9483:SLBP ^@ http://purl.uniprot.org/uniprot/U3DWT0 ^@ Similarity ^@ Belongs to the SLBP family. http://togogenome.org/gene/9483:CALCB ^@ http://purl.uniprot.org/uniprot/U3BRR6 ^@ Similarity ^@ Belongs to the calcitonin family. http://togogenome.org/gene/9483:HSPD1 ^@ http://purl.uniprot.org/uniprot/U3D4H6 ^@ Similarity ^@ Belongs to the chaperonin (HSP60) family. http://togogenome.org/gene/9483:BMP4 ^@ http://purl.uniprot.org/uniprot/A0A5F4VXA0 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9483:TTC9C ^@ http://purl.uniprot.org/uniprot/F7I606 ^@ Similarity ^@ Belongs to the TTC9 family. http://togogenome.org/gene/9483:GOLGA5 ^@ http://purl.uniprot.org/uniprot/U3AUC3|||http://purl.uniprot.org/uniprot/U3ENU1 ^@ Function|||Subcellular Location Annotation ^@ Golgi apparatus membrane|||Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. http://togogenome.org/gene/9483:WNT2 ^@ http://purl.uniprot.org/uniprot/Q2QLG1|||http://purl.uniprot.org/uniprot/U3E233 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).|||Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.|||Secreted|||extracellular matrix http://togogenome.org/gene/9483:LOC100390960 ^@ http://purl.uniprot.org/uniprot/F7I4P8 ^@ Similarity ^@ Belongs to the MORF4 family-associated protein family. http://togogenome.org/gene/9483:ERLEC1 ^@ http://purl.uniprot.org/uniprot/A0A2R8M3S9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OS-9 family.|||Endoplasmic reticulum lumen|||Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation. http://togogenome.org/gene/9483:RAB5IF ^@ http://purl.uniprot.org/uniprot/A0A5F4WDB7|||http://purl.uniprot.org/uniprot/F7IE30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMC6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:NPM1 ^@ http://purl.uniprot.org/uniprot/F7FL37 ^@ Similarity ^@ Belongs to the nucleoplasmin family. http://togogenome.org/gene/9483:LOC100401345 ^@ http://purl.uniprot.org/uniprot/A0A8I3WUH7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9483:GCK ^@ http://purl.uniprot.org/uniprot/A0A8I4A2C9 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/9483:XRN1 ^@ http://purl.uniprot.org/uniprot/F7GUR3|||http://purl.uniprot.org/uniprot/U3CD29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 5'-3' exonuclease family.|||Cytoplasm http://togogenome.org/gene/9483:GPER1 ^@ http://purl.uniprot.org/uniprot/F7G601 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:ABAT ^@ http://purl.uniprot.org/uniprot/U3CEZ2 ^@ Similarity|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9483:IGFBP5 ^@ http://purl.uniprot.org/uniprot/F7HYX2 ^@ Caution|||Function|||Subcellular Location Annotation ^@ IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9483:EXOSC2 ^@ http://purl.uniprot.org/uniprot/A0A5F4VWK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP4 family.|||Cytoplasm http://togogenome.org/gene/9483:BCL7A ^@ http://purl.uniprot.org/uniprot/F6W7A2|||http://purl.uniprot.org/uniprot/U3C447 ^@ Similarity ^@ Belongs to the BCL7 family. http://togogenome.org/gene/9483:KCNJ2 ^@ http://purl.uniprot.org/uniprot/F6W2Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.|||Membrane http://togogenome.org/gene/9483:ESYT1 ^@ http://purl.uniprot.org/uniprot/F6RL52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the extended synaptotagmin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:HACD4 ^@ http://purl.uniprot.org/uniprot/A0A8I3WTI7|||http://purl.uniprot.org/uniprot/F6WUZ8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:BBS5 ^@ http://purl.uniprot.org/uniprot/F7EG67 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BBS5 family.|||Membrane|||Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10.|||The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.|||centriolar satellite|||cilium membrane http://togogenome.org/gene/9483:GJC2 ^@ http://purl.uniprot.org/uniprot/F7H2L5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9483:TACR1 ^@ http://purl.uniprot.org/uniprot/F7HYI8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with ARRB1.|||Membrane http://togogenome.org/gene/9483:PRKCG ^@ http://purl.uniprot.org/uniprot/F7CPU6 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.|||Cytoplasm|||Membrane http://togogenome.org/gene/9483:TMEM98 ^@ http://purl.uniprot.org/uniprot/F6ZJ86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM98 family.|||Endoplasmic reticulum membrane|||Membrane|||extracellular exosome http://togogenome.org/gene/9483:SLC6A4 ^@ http://purl.uniprot.org/uniprot/F7BZJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.|||Cell membrane|||Endomembrane system|||Endosome membrane|||Membrane|||Synapse|||focal adhesion|||neuron projection http://togogenome.org/gene/9483:ROGDI ^@ http://purl.uniprot.org/uniprot/U3BVX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rogdi family.|||Presynapse|||Vesicle|||synaptic vesicle http://togogenome.org/gene/9483:ELOF1 ^@ http://purl.uniprot.org/uniprot/F7ABX0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELOF1 family.|||Nucleus|||Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. http://togogenome.org/gene/9483:FIP1L1 ^@ http://purl.uniprot.org/uniprot/F6XL63|||http://purl.uniprot.org/uniprot/F7HU37|||http://purl.uniprot.org/uniprot/F7HU47|||http://purl.uniprot.org/uniprot/U3CCA9|||http://purl.uniprot.org/uniprot/U3D9W1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FIP1 family.|||Nucleus http://togogenome.org/gene/9483:F9 ^@ http://purl.uniprot.org/uniprot/A0A8I3W9Z9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9483:IL18RAP ^@ http://purl.uniprot.org/uniprot/F6X906 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9483:TUT4 ^@ http://purl.uniprot.org/uniprot/U3CNC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B-like family.|||Cytoplasm http://togogenome.org/gene/9483:ACTR10 ^@ http://purl.uniprot.org/uniprot/F7I3K4 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9483:ITPK1 ^@ http://purl.uniprot.org/uniprot/U3E1V5 ^@ Similarity ^@ Belongs to the ITPK1 family. http://togogenome.org/gene/9483:NOP58 ^@ http://purl.uniprot.org/uniprot/F7IB06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP5/NOP56 family.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9483:STX17 ^@ http://purl.uniprot.org/uniprot/U3BX97 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9483:LRWD1 ^@ http://purl.uniprot.org/uniprot/U3EMU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRWD1 family.|||centrosome|||kinetochore|||telomere http://togogenome.org/gene/9483:ART1 ^@ http://purl.uniprot.org/uniprot/U3DQM6 ^@ Similarity ^@ Belongs to the Arg-specific ADP-ribosyltransferase family. http://togogenome.org/gene/9483:SSX4B ^@ http://purl.uniprot.org/uniprot/A0A2R8M6L0 ^@ Similarity ^@ Belongs to the SSX family. http://togogenome.org/gene/9483:CPOX ^@ http://purl.uniprot.org/uniprot/U3CYT7 ^@ Similarity|||Subunit ^@ Belongs to the aerobic coproporphyrinogen-III oxidase family.|||Homodimer. http://togogenome.org/gene/9483:TBK1 ^@ http://purl.uniprot.org/uniprot/A0A8I3WD22|||http://purl.uniprot.org/uniprot/U3D758 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:CYP8B1 ^@ http://purl.uniprot.org/uniprot/A0A7G0Y586 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9483:GPRIN3 ^@ http://purl.uniprot.org/uniprot/U3FMS2 ^@ Function ^@ May be involved in neurite outgrowth. http://togogenome.org/gene/9483:SEPTIN10 ^@ http://purl.uniprot.org/uniprot/U3F240 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9483:SPCS2 ^@ http://purl.uniprot.org/uniprot/F7IAN3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS2 family.|||Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:PIH1D1 ^@ http://purl.uniprot.org/uniprot/U3CVS6 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/9483:MED17 ^@ http://purl.uniprot.org/uniprot/U3DKL9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 17 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9483:SPIC ^@ http://purl.uniprot.org/uniprot/F7HYR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9483:PFKFB4 ^@ http://purl.uniprot.org/uniprot/U3EVT9 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/9483:DCLK1 ^@ http://purl.uniprot.org/uniprot/A0A5F4WN18 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9483:CCL2 ^@ http://purl.uniprot.org/uniprot/A0A5F4WHC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9483:CDC42SE2 ^@ http://purl.uniprot.org/uniprot/F7IIP9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CDC42SE/SPEC family.|||Cell membrane|||Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.|||Membrane|||Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.|||cytoskeleton http://togogenome.org/gene/9483:DIS3 ^@ http://purl.uniprot.org/uniprot/F7CVL7|||http://purl.uniprot.org/uniprot/U3D226 ^@ Similarity ^@ Belongs to the RNR ribonuclease family. http://togogenome.org/gene/9483:ELOVL7 ^@ http://purl.uniprot.org/uniprot/F6VQ90 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL7 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Membrane|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9483:CYP2J2 ^@ http://purl.uniprot.org/uniprot/A0A1P8NQJ2 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9483:SUPT4H1 ^@ http://purl.uniprot.org/uniprot/H9KXA4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT4 family.|||Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.|||Nucleus http://togogenome.org/gene/9483:TIMM17B ^@ http://purl.uniprot.org/uniprot/F6Y398 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9483:RHBDD1 ^@ http://purl.uniprot.org/uniprot/F7HNU5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:MRPL9 ^@ http://purl.uniprot.org/uniprot/B0KWD3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family. http://togogenome.org/gene/9483:GPR15 ^@ http://purl.uniprot.org/uniprot/F7GUM7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9483:MS4A5 ^@ http://purl.uniprot.org/uniprot/F7BSN1 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9483:RLN3 ^@ http://purl.uniprot.org/uniprot/F7I420 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/9483:B3GALT4 ^@ http://purl.uniprot.org/uniprot/U3DX13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:LEPROT ^@ http://purl.uniprot.org/uniprot/A0A5F4VXX7|||http://purl.uniprot.org/uniprot/F7IAD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OB-RGRP/VPS55 family.|||Membrane http://togogenome.org/gene/9483:GADD45GIP1 ^@ http://purl.uniprot.org/uniprot/U3DS82 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.|||Belongs to the mitochondrion-specific ribosomal protein mL64 family.|||Mitochondrion|||Nucleus http://togogenome.org/gene/9483:NDUFS1 ^@ http://purl.uniprot.org/uniprot/A0A8I3WKW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I 75 kDa subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:ZDHHC5 ^@ http://purl.uniprot.org/uniprot/F6XIT1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9483:ATXN2 ^@ http://purl.uniprot.org/uniprot/F6SS84 ^@ Similarity ^@ Belongs to the ataxin-2 family. http://togogenome.org/gene/9483:SH3GL3 ^@ http://purl.uniprot.org/uniprot/U3CYS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Membrane http://togogenome.org/gene/9483:SDHAF3 ^@ http://purl.uniprot.org/uniprot/A0A2R8M3V2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I LYR family. SDHAF3 subfamily.|||Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.|||Mitochondrion matrix|||Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1. http://togogenome.org/gene/9483:TFPI2 ^@ http://purl.uniprot.org/uniprot/U3ENJ1 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9483:TRDMT1 ^@ http://purl.uniprot.org/uniprot/F6URL6 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. http://togogenome.org/gene/9483:CNKSR3 ^@ http://purl.uniprot.org/uniprot/U3BPL9 ^@ Similarity ^@ Belongs to the CNKSR family. http://togogenome.org/gene/9483:SLC2A1 ^@ http://purl.uniprot.org/uniprot/F6PYB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Cell membrane|||Membrane|||Photoreceptor inner segment http://togogenome.org/gene/9483:CDC42EP1 ^@ http://purl.uniprot.org/uniprot/F7B9V2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/9483:RHBDL2 ^@ http://purl.uniprot.org/uniprot/F7C7A4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S54 family.|||Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.|||Membrane http://togogenome.org/gene/9483:NCAPG ^@ http://purl.uniprot.org/uniprot/F7GVY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CND3 (condensin subunit 3) family.|||Chromosome http://togogenome.org/gene/9483:HMGB2 ^@ http://purl.uniprot.org/uniprot/F7HD57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/9483:CPSF7 ^@ http://purl.uniprot.org/uniprot/F7HI00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM CPSF6/7 family.|||Nucleus http://togogenome.org/gene/9483:PITX3 ^@ http://purl.uniprot.org/uniprot/F7GQI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9483:HMBS ^@ http://purl.uniprot.org/uniprot/U3FF00 ^@ Similarity ^@ Belongs to the HMBS family. http://togogenome.org/gene/9483:PSMB5 ^@ http://purl.uniprot.org/uniprot/A0A8J8XYY2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:KCNK13 ^@ http://purl.uniprot.org/uniprot/A0A5F4WKS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9483:DHDH ^@ http://purl.uniprot.org/uniprot/F7FPG8 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. http://togogenome.org/gene/9483:THOC2 ^@ http://purl.uniprot.org/uniprot/B0KWH8|||http://purl.uniprot.org/uniprot/F7ESC3|||http://purl.uniprot.org/uniprot/U3CR12 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the THOC2 family.|||Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with THOC1, POLDIP3 and ZC3H11A (By similarity).|||Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with THOC1, POLDIP3 and ZC3H11A.|||Nucleus|||Nucleus speckle|||Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. Plays a role for proper neuronal development. http://togogenome.org/gene/9483:TNFSF14 ^@ http://purl.uniprot.org/uniprot/A0A8I3WAJ4 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9483:LDAF1 ^@ http://purl.uniprot.org/uniprot/F7I8L4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LDAF1 family.|||Endoplasmic reticulum membrane|||Lipid droplet|||Membrane http://togogenome.org/gene/9483:ZIC3 ^@ http://purl.uniprot.org/uniprot/U3ER80 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/9483:SCD ^@ http://purl.uniprot.org/uniprot/U3DJ56 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Membrane|||The histidine box domains are involved in binding the catalytic metal ions. http://togogenome.org/gene/9483:MLEC ^@ http://purl.uniprot.org/uniprot/F7IL56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the malectin family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:MYMK ^@ http://purl.uniprot.org/uniprot/A0A8I4A636 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:NAPB ^@ http://purl.uniprot.org/uniprot/U3FUU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/9483:GFM1 ^@ http://purl.uniprot.org/uniprot/U3E9C4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.|||Mitochondrion http://togogenome.org/gene/9483:ZMPSTE24 ^@ http://purl.uniprot.org/uniprot/U3DGC2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48A family.|||Binds 1 zinc ion per subunit.|||Endoplasmic reticulum membrane|||Proteolytically removes the C-terminal three residues of farnesylated proteins. http://togogenome.org/gene/9483:CCNYL1 ^@ http://purl.uniprot.org/uniprot/F7HYI9 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin Y subfamily. http://togogenome.org/gene/9483:GK5 ^@ http://purl.uniprot.org/uniprot/F7F132 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/9483:SPTBN1 ^@ http://purl.uniprot.org/uniprot/F7H0A9|||http://purl.uniprot.org/uniprot/U3CSG0 ^@ Similarity ^@ Belongs to the spectrin family. http://togogenome.org/gene/9483:TMEM17 ^@ http://purl.uniprot.org/uniprot/F7DAD8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:CD163 ^@ http://purl.uniprot.org/uniprot/A0A8I3W566|||http://purl.uniprot.org/uniprot/U3DT72|||http://purl.uniprot.org/uniprot/U3F8N3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:CCL5 ^@ http://purl.uniprot.org/uniprot/A0A5F4W4J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9483:MCOLN3 ^@ http://purl.uniprot.org/uniprot/F6RG56 ^@ Activity Regulation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transient receptor (TC 1.A.4) family. Polycystin subfamily. MCOLN3 sub-subfamily.|||Channel activity is activated by PtdIns(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) (PubMed:29019979). Inhibited by lumenal H(+) and Na(+). The channel pore shows dynamic behavior and undergoes spontaneous, Ca(2+)-dependent modulation when conducting Ca(2+).|||Early endosome membrane|||Homotetramer (PubMed:29019979). Can heterooligomerize with MCOLN1; heteromeric assemblies have different channel properties as compared to the respective homooligomers and may be tissue-specific. May heterooligomerize with TRPV5 to form a functional distinct ion channel (By similarity). Interacts with GABARAPL2 (By similarity).|||Late endosome membrane|||Lysosome membrane|||N-glycosylated.|||Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events (PubMed:29019979). Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (By similarity). Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway (By similarity). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth. Involved in the regulation of autophagy. Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca(2+) for the fusion process (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events. Possible heteromeric ion channel assemblies with TRPV5 show pharmacological similarity with TRPML3 (By similarity).|||The most N-terminal extracellular/lumenal domain (referred to as I-II linker or polycystin-mucolipin domain) contributes to a structure with a four-fold rotational symmetry in a tetrameric assembly; the structure contains a central highly electronegative pore with a 14 A diameter. The pore is critical for Ca(2+) and pH regulation. The protruding structure formed by the I-II linkers may contain all the interaction sites with lipids and proteins in the endolysosomal lumen.|||autophagosome membrane|||stereocilium membrane http://togogenome.org/gene/9483:MRPL11 ^@ http://purl.uniprot.org/uniprot/F7I4I1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL11 family. http://togogenome.org/gene/9483:CHEK1 ^@ http://purl.uniprot.org/uniprot/A0A8I3W5B3|||http://purl.uniprot.org/uniprot/F7GZH4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily. http://togogenome.org/gene/9483:WNT6 ^@ http://purl.uniprot.org/uniprot/A0A5F4VXK1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9483:CYP2D19 ^@ http://purl.uniprot.org/uniprot/A0A171P0Z0|||http://purl.uniprot.org/uniprot/O18992 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane|||P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.|||Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. http://togogenome.org/gene/9483:LYRM1 ^@ http://purl.uniprot.org/uniprot/F6RTD1 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9483:CYBASC3 ^@ http://purl.uniprot.org/uniprot/F7H7P9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:CCL19 ^@ http://purl.uniprot.org/uniprot/F7BQ31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9483:MMD ^@ http://purl.uniprot.org/uniprot/A0A2R8MEW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9483:PAH ^@ http://purl.uniprot.org/uniprot/A0A8I4A1R1 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/9483:SNRPA1 ^@ http://purl.uniprot.org/uniprot/F7IJG0 ^@ Similarity ^@ Belongs to the U2 small nuclear ribonucleoprotein A family. http://togogenome.org/gene/9483:FGF6 ^@ http://purl.uniprot.org/uniprot/F7I4D7 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9483:KRT222 ^@ http://purl.uniprot.org/uniprot/U3EVW2 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9483:DYNC1LI1 ^@ http://purl.uniprot.org/uniprot/U3DNE9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.|||Belongs to the dynein light intermediate chain family.|||Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).|||cytoskeleton http://togogenome.org/gene/9483:MCUB ^@ http://purl.uniprot.org/uniprot/F7I7H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCU (TC 1.A.77) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9483:RNMT ^@ http://purl.uniprot.org/uniprot/U3EIZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.|||In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.|||Nucleus http://togogenome.org/gene/9483:ARSJ ^@ http://purl.uniprot.org/uniprot/A0A8I3WK19 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9483:CES4A ^@ http://purl.uniprot.org/uniprot/F7A7N6 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/9483:TMEM256 ^@ http://purl.uniprot.org/uniprot/F6V825 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM256 family.|||Membrane http://togogenome.org/gene/9483:PPOX ^@ http://purl.uniprot.org/uniprot/F7GX92 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.|||Binds 1 FAD per subunit.|||Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:IL6R ^@ http://purl.uniprot.org/uniprot/Q0PIT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 3 subfamily.|||Membrane http://togogenome.org/gene/9483:TOP2A ^@ http://purl.uniprot.org/uniprot/F6T9B4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II topoisomerase family.|||Homodimer.|||Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9483:PHKG1 ^@ http://purl.uniprot.org/uniprot/U3CUK8 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily.|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin. http://togogenome.org/gene/9483:PCID2 ^@ http://purl.uniprot.org/uniprot/F6QNT5 ^@ Similarity ^@ Belongs to the CSN12 family. http://togogenome.org/gene/9483:MDM1 ^@ http://purl.uniprot.org/uniprot/U3BUY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM1 family.|||Nucleus|||centriole http://togogenome.org/gene/9483:FAM167A ^@ http://purl.uniprot.org/uniprot/F6U0Y2 ^@ Similarity ^@ Belongs to the FAM167 (SEC) family. http://togogenome.org/gene/9483:CPT1B ^@ http://purl.uniprot.org/uniprot/U3EYN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the carnitine/choline acetyltransferase family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9483:MAN1A1 ^@ http://purl.uniprot.org/uniprot/F6QEE1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9483:HBS1L ^@ http://purl.uniprot.org/uniprot/A0A5F4VQZ5|||http://purl.uniprot.org/uniprot/F7HXM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm http://togogenome.org/gene/9483:SLC35D2 ^@ http://purl.uniprot.org/uniprot/F7GT05|||http://purl.uniprot.org/uniprot/F7IKP5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:DIPK2A ^@ http://purl.uniprot.org/uniprot/U3CMQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Secreted http://togogenome.org/gene/9483:NDUFAF1 ^@ http://purl.uniprot.org/uniprot/F7HZT7 ^@ Function|||Similarity ^@ As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.|||Belongs to the CIA30 family. http://togogenome.org/gene/9483:GJD2 ^@ http://purl.uniprot.org/uniprot/F7H014 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9483:IZUMO4 ^@ http://purl.uniprot.org/uniprot/F7H3X4|||http://purl.uniprot.org/uniprot/U3EHC0 ^@ Similarity ^@ Belongs to the Izumo family. http://togogenome.org/gene/9483:ZPR1 ^@ http://purl.uniprot.org/uniprot/B0KWQ8 ^@ Similarity ^@ Belongs to the ZPR1 family. http://togogenome.org/gene/9483:TMEM35A ^@ http://purl.uniprot.org/uniprot/F7HTX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Membrane http://togogenome.org/gene/9483:BET1 ^@ http://purl.uniprot.org/uniprot/A0A8I3X9Z6|||http://purl.uniprot.org/uniprot/U3BHD7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:HSD17B6 ^@ http://purl.uniprot.org/uniprot/F6TYQ7 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9483:UNC45B ^@ http://purl.uniprot.org/uniprot/U3CNZ8 ^@ Subcellular Location Annotation ^@ A band|||Z line|||perinuclear region http://togogenome.org/gene/9483:GPATCH1 ^@ http://purl.uniprot.org/uniprot/F6ZI94 ^@ Similarity ^@ Belongs to the GPATCH1 family. http://togogenome.org/gene/9483:MGA ^@ http://purl.uniprot.org/uniprot/F7INH6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9483:MRPL19 ^@ http://purl.uniprot.org/uniprot/U3B9S5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family. http://togogenome.org/gene/9483:GTF2H5 ^@ http://purl.uniprot.org/uniprot/F7HBD9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB5 family.|||Component of the 7-subunit TFIIH core complex.|||In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.|||Nucleus http://togogenome.org/gene/9483:LIN28B ^@ http://purl.uniprot.org/uniprot/A0A2R8M7B5 ^@ Similarity ^@ Belongs to the lin-28 family. http://togogenome.org/gene/9483:ARMC1 ^@ http://purl.uniprot.org/uniprot/F7CGM3 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9483:OLFR564 ^@ http://purl.uniprot.org/uniprot/B0VX92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:PLPP4 ^@ http://purl.uniprot.org/uniprot/U3EQ67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9483:TRMO ^@ http://purl.uniprot.org/uniprot/F7GKW7|||http://purl.uniprot.org/uniprot/F7GL28 ^@ Similarity ^@ Belongs to the tRNA methyltransferase O family. http://togogenome.org/gene/9483:LOC100405332 ^@ http://purl.uniprot.org/uniprot/F6UCC7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.|||Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/9483:NDUFA8 ^@ http://purl.uniprot.org/uniprot/F7CDP2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA8 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/9483:PAM ^@ http://purl.uniprot.org/uniprot/A0A8J8XJX7|||http://purl.uniprot.org/uniprot/F7IJS3|||http://purl.uniprot.org/uniprot/U3F7L2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Binds 2 Cu(2+) ions per subunit.|||Binds one Zn(2+) ion per subunit.|||In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.|||In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.|||Membrane|||secretory vesicle membrane http://togogenome.org/gene/9483:YIPF4 ^@ http://purl.uniprot.org/uniprot/U3C455 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:RAB33B ^@ http://purl.uniprot.org/uniprot/F7I2X6 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Rab family. http://togogenome.org/gene/9483:DIPK1A ^@ http://purl.uniprot.org/uniprot/A0A8I3WV24|||http://purl.uniprot.org/uniprot/F7FIM1 ^@ Similarity ^@ Belongs to the DIPK family. http://togogenome.org/gene/9483:LIAS ^@ http://purl.uniprot.org/uniprot/F6ZHY4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Mitochondrion http://togogenome.org/gene/9483:UBE2L3 ^@ http://purl.uniprot.org/uniprot/F7I7Z9 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9483:SLC12A5 ^@ http://purl.uniprot.org/uniprot/A0A8J8XPH1|||http://purl.uniprot.org/uniprot/U3CZY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9483:KRT17 ^@ http://purl.uniprot.org/uniprot/F7ANB4 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9483:CACNB4 ^@ http://purl.uniprot.org/uniprot/F7GGT8|||http://purl.uniprot.org/uniprot/U3D4S4|||http://purl.uniprot.org/uniprot/U3EX85 ^@ Similarity ^@ Belongs to the calcium channel beta subunit family. http://togogenome.org/gene/9483:ATP5PB ^@ http://purl.uniprot.org/uniprot/F7GCT3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ATPase B chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) has three main subunits: a, b and c.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion|||Mitochondrion inner membrane http://togogenome.org/gene/9483:CD109 ^@ http://purl.uniprot.org/uniprot/A0A2R8P684 ^@ Similarity ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. http://togogenome.org/gene/9483:PGK2 ^@ http://purl.uniprot.org/uniprot/F7FGX4 ^@ Similarity|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Monomer. http://togogenome.org/gene/9483:CERS5 ^@ http://purl.uniprot.org/uniprot/F7F1C1 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9483:PROKR2 ^@ http://purl.uniprot.org/uniprot/A0A8I3WBY1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9483:SNX7 ^@ http://purl.uniprot.org/uniprot/A0A8J8YIN2 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9483:MRPS26 ^@ http://purl.uniprot.org/uniprot/U3CMR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS26 family.|||Mitochondrion http://togogenome.org/gene/9483:PPP4R3B ^@ http://purl.uniprot.org/uniprot/U3DMP4 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/9483:RPS9 ^@ http://purl.uniprot.org/uniprot/B0VXI8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/9483:ZHX2 ^@ http://purl.uniprot.org/uniprot/F7I6W4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZHX family.|||Nucleus http://togogenome.org/gene/9483:LBR ^@ http://purl.uniprot.org/uniprot/A0A8I3W699|||http://purl.uniprot.org/uniprot/A0A8I3WE83|||http://purl.uniprot.org/uniprot/U3BM96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/9483:ENTREP3 ^@ http://purl.uniprot.org/uniprot/U3DCX5|||http://purl.uniprot.org/uniprot/U3E4E0 ^@ Similarity ^@ Belongs to the ENTREP family. http://togogenome.org/gene/9483:HOMER2 ^@ http://purl.uniprot.org/uniprot/F7IP78|||http://purl.uniprot.org/uniprot/U3D810 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Homer family.|||Cytoplasm|||Postsynaptic density|||Synapse http://togogenome.org/gene/9483:UTP23 ^@ http://purl.uniprot.org/uniprot/F7HWG8 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9483:DDX56 ^@ http://purl.uniprot.org/uniprot/F7IAV9 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9483:NR0B2 ^@ http://purl.uniprot.org/uniprot/F7H657 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR0 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:KCNJ16 ^@ http://purl.uniprot.org/uniprot/F7IRC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9483:RBM17 ^@ http://purl.uniprot.org/uniprot/F7INM9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with the spliceosome.|||Nucleus|||Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. http://togogenome.org/gene/9483:CRHBP ^@ http://purl.uniprot.org/uniprot/U3C1E0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CRF-binding protein family.|||Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.|||Secreted http://togogenome.org/gene/9483:FABP4 ^@ http://purl.uniprot.org/uniprot/F6SD36 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9483:SLC29A2 ^@ http://purl.uniprot.org/uniprot/U3D679 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Basolateral cell membrane|||Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9483:RASGRP3 ^@ http://purl.uniprot.org/uniprot/U3FQ81 ^@ Similarity ^@ Belongs to the RASGRP family. http://togogenome.org/gene/9483:PMM1 ^@ http://purl.uniprot.org/uniprot/U3DRA6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic PMM family.|||Cytoplasm|||Homodimer.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/9483:GDF10 ^@ http://purl.uniprot.org/uniprot/F6UYX9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer.|||Secreted http://togogenome.org/gene/9483:WARS2 ^@ http://purl.uniprot.org/uniprot/F7EFP4 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9483:FAM131C ^@ http://purl.uniprot.org/uniprot/U3FI24 ^@ Similarity ^@ Belongs to the FAM131 family. http://togogenome.org/gene/9483:RPL27 ^@ http://purl.uniprot.org/uniprot/F7I424 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL27 family.|||Endoplasmic reticulum|||Rough endoplasmic reticulum http://togogenome.org/gene/9483:ENO2 ^@ http://purl.uniprot.org/uniprot/F6QLJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/9483:ATP11A ^@ http://purl.uniprot.org/uniprot/A0A2R8N6S8|||http://purl.uniprot.org/uniprot/A0A8I3VWN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9483:CSE1L ^@ http://purl.uniprot.org/uniprot/F6Y7A9|||http://purl.uniprot.org/uniprot/F7BAH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPO2/CSE1 family.|||Cytoplasm http://togogenome.org/gene/9483:DLG1 ^@ http://purl.uniprot.org/uniprot/F6UVX1|||http://purl.uniprot.org/uniprot/F7IK82|||http://purl.uniprot.org/uniprot/U3E5S9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Membrane http://togogenome.org/gene/9483:STAR ^@ http://purl.uniprot.org/uniprot/F7ALD0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ May interact with TSPO.|||Mitochondrion|||Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. http://togogenome.org/gene/9483:GMPPA ^@ http://purl.uniprot.org/uniprot/B0KWJ2 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/9483:NMNAT3 ^@ http://purl.uniprot.org/uniprot/A0A2R8MMF5 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/9483:GBX2 ^@ http://purl.uniprot.org/uniprot/A0A2R8NEK0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:PHETA2 ^@ http://purl.uniprot.org/uniprot/H9KVS6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sesquipedalian family.|||Early endosome|||Forms homodimers and heterodimers with PHETA. Interacts with OCRL and INPP5B.|||Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.|||Recycling endosome|||clathrin-coated vesicle|||trans-Golgi network http://togogenome.org/gene/9483:SCAND1 ^@ http://purl.uniprot.org/uniprot/U3CYJ8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:EMX2 ^@ http://purl.uniprot.org/uniprot/F7E5H5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:TMPO ^@ http://purl.uniprot.org/uniprot/F6YNR4|||http://purl.uniprot.org/uniprot/F7CUJ3|||http://purl.uniprot.org/uniprot/U3EN66 ^@ Similarity ^@ Belongs to the LEM family. http://togogenome.org/gene/9483:PPP1R35 ^@ http://purl.uniprot.org/uniprot/F6VQG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP1R35 family.|||centriole http://togogenome.org/gene/9483:MFAP1 ^@ http://purl.uniprot.org/uniprot/B0KWG5 ^@ Function|||Similarity ^@ Belongs to the MFAP1 family.|||Involved in pre-mRNA splicing as a component of the spliceosome. http://togogenome.org/gene/9483:AP4E1 ^@ http://purl.uniprot.org/uniprot/U3E0Y1 ^@ Function|||Similarity|||Subunit ^@ Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins, a medium adaptin and a small adaptin.|||Belongs to the adaptor complexes large subunit family.|||Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. http://togogenome.org/gene/9483:STMN4 ^@ http://purl.uniprot.org/uniprot/A0A8I3WA26|||http://purl.uniprot.org/uniprot/F6QV67|||http://purl.uniprot.org/uniprot/U3FXQ2 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/9483:SLC26A2 ^@ http://purl.uniprot.org/uniprot/F7H3N7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane|||Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development. Mediates electroneutral anion exchange of sulfate ions for oxalate ions, sulfate and oxalate ions for chloride and/or hydroxyl ions and chloride ions for bromide, iodide and nitrate ions. The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange. Essential for chondrocyte proliferation, differentiation and cell size expansion. http://togogenome.org/gene/9483:TMEM45B ^@ http://purl.uniprot.org/uniprot/U3D5I0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/9483:ADAMTS3 ^@ http://purl.uniprot.org/uniprot/F7IQZ2 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9483:FUT9 ^@ http://purl.uniprot.org/uniprot/F7I511 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9483:CTBP2 ^@ http://purl.uniprot.org/uniprot/F7I3J2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Nucleus http://togogenome.org/gene/9483:NPLOC4 ^@ http://purl.uniprot.org/uniprot/A0A8I3XDR6|||http://purl.uniprot.org/uniprot/U3CGX0 ^@ Similarity ^@ Belongs to the NPL4 family. http://togogenome.org/gene/9483:TIMM17A ^@ http://purl.uniprot.org/uniprot/F7IHY3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9483:CCK ^@ http://purl.uniprot.org/uniprot/U3DR24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gastrin/cholecystokinin family.|||Secreted http://togogenome.org/gene/9483:PDK4 ^@ http://purl.uniprot.org/uniprot/F7GY25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9483:ITPKB ^@ http://purl.uniprot.org/uniprot/U3FPY5 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9483:LOC100896017 ^@ http://purl.uniprot.org/uniprot/A0A5F4WIS5 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9483:SRC ^@ http://purl.uniprot.org/uniprot/A0A5F4W7Z4|||http://purl.uniprot.org/uniprot/F6W7M1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9483:CLNS1A ^@ http://purl.uniprot.org/uniprot/A0A2R8MJB4|||http://purl.uniprot.org/uniprot/U3FEP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pICln (TC 1.A.47) family.|||Nucleus http://togogenome.org/gene/9483:CYB561 ^@ http://purl.uniprot.org/uniprot/A0A8I3X570|||http://purl.uniprot.org/uniprot/A0A8J8XKZ9|||http://purl.uniprot.org/uniprot/U3C0Q0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:PGAP3 ^@ http://purl.uniprot.org/uniprot/F6Y4P4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PGAP3 family.|||Golgi apparatus membrane|||Involved in the lipid remodeling steps of GPI-anchor maturation.|||Membrane http://togogenome.org/gene/9483:PRAME ^@ http://purl.uniprot.org/uniprot/F7CS78 ^@ Similarity ^@ Belongs to the PRAME family. http://togogenome.org/gene/9483:YPEL2 ^@ http://purl.uniprot.org/uniprot/U3CVF8 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9483:LOC108591261 ^@ http://purl.uniprot.org/uniprot/F7H244 ^@ Similarity ^@ Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family. http://togogenome.org/gene/9483:GUCY1B1 ^@ http://purl.uniprot.org/uniprot/U3FX94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Cytoplasm http://togogenome.org/gene/9483:DDIT4 ^@ http://purl.uniprot.org/uniprot/F6X5P2 ^@ Similarity ^@ Belongs to the DDIT4 family. http://togogenome.org/gene/9483:XYLB ^@ http://purl.uniprot.org/uniprot/F7GVM7 ^@ Function|||Similarity ^@ Belongs to the FGGY kinase family.|||Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis. http://togogenome.org/gene/9483:TRIM28 ^@ http://purl.uniprot.org/uniprot/U3E3Y4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:ARL8B ^@ http://purl.uniprot.org/uniprot/F7I8E9 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Late endosome membrane|||Lysosome membrane|||axon|||spindle http://togogenome.org/gene/9483:GFOD2 ^@ http://purl.uniprot.org/uniprot/U3F7H2 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. http://togogenome.org/gene/9483:CD34 ^@ http://purl.uniprot.org/uniprot/Q76II1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:GPC4 ^@ http://purl.uniprot.org/uniprot/U3DQ14 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/9483:STRIP2 ^@ http://purl.uniprot.org/uniprot/F6QYE5 ^@ Similarity ^@ Belongs to the STRIP family. http://togogenome.org/gene/9483:EIF2AK3 ^@ http://purl.uniprot.org/uniprot/F7GGK0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9483:IFRD1 ^@ http://purl.uniprot.org/uniprot/F7IPH5 ^@ Similarity ^@ Belongs to the IFRD family. http://togogenome.org/gene/9483:CLDN8 ^@ http://purl.uniprot.org/uniprot/U3DEN6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9483:VPS33A ^@ http://purl.uniprot.org/uniprot/A0A8I3VXI5|||http://purl.uniprot.org/uniprot/U3D5U9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STXBP/unc-18/SEC1 family.|||Early endosome|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||clathrin-coated vesicle http://togogenome.org/gene/9483:AFF4 ^@ http://purl.uniprot.org/uniprot/B0KWQ0 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/9483:LOC103792017 ^@ http://purl.uniprot.org/uniprot/A0A6G6XDN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9483:NRN1 ^@ http://purl.uniprot.org/uniprot/U3EMR7 ^@ Similarity ^@ Belongs to the neuritin family. http://togogenome.org/gene/9483:FGGY ^@ http://purl.uniprot.org/uniprot/U3F890 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/9483:GADD45G ^@ http://purl.uniprot.org/uniprot/F7HV04 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/9483:MED6 ^@ http://purl.uniprot.org/uniprot/F7FFB0|||http://purl.uniprot.org/uniprot/U3EBM2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 6 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9483:MCTS2 ^@ http://purl.uniprot.org/uniprot/U3ECM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCTS1 family.|||Cytoplasm http://togogenome.org/gene/9483:HAO2 ^@ http://purl.uniprot.org/uniprot/F7AA83 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/9483:HK2 ^@ http://purl.uniprot.org/uniprot/F7HCY2 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/9483:HEXIM1 ^@ http://purl.uniprot.org/uniprot/F7F2K3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HEXIM family.|||Nucleus http://togogenome.org/gene/9483:VAMP4 ^@ http://purl.uniprot.org/uniprot/F6W2F6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9483:PLA2G2F ^@ http://purl.uniprot.org/uniprot/F7DRN8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9483:ACLY ^@ http://purl.uniprot.org/uniprot/F7DBY4|||http://purl.uniprot.org/uniprot/F7DSU4 ^@ Function|||Similarity|||Subunit ^@ Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.|||Homotetramer.|||In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.|||In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. http://togogenome.org/gene/9483:DBX2 ^@ http://purl.uniprot.org/uniprot/U3CRZ0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:TNNT2 ^@ http://purl.uniprot.org/uniprot/F7HC37 ^@ Function|||Similarity ^@ Belongs to the troponin T family.|||Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. http://togogenome.org/gene/9483:NDUFAF3 ^@ http://purl.uniprot.org/uniprot/F6VFE1 ^@ Function|||Subcellular Location Annotation ^@ Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).|||Membrane|||Mitochondrion inner membrane|||Nucleus http://togogenome.org/gene/9483:DNASE2B ^@ http://purl.uniprot.org/uniprot/F6WHU9 ^@ Similarity ^@ Belongs to the DNase II family. http://togogenome.org/gene/9483:TFB1M ^@ http://purl.uniprot.org/uniprot/U3FDQ9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.|||Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.|||S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. http://togogenome.org/gene/9483:FAM149B1 ^@ http://purl.uniprot.org/uniprot/F7HP81 ^@ Similarity ^@ Belongs to the FAM149 family. http://togogenome.org/gene/9483:XKRX ^@ http://purl.uniprot.org/uniprot/A0A5K1UT75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9483:ATP5IF1 ^@ http://purl.uniprot.org/uniprot/F7IA10 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase inhibitor family.|||Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.|||Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.|||Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.|||Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.|||Mitochondrion http://togogenome.org/gene/9483:BAAT ^@ http://purl.uniprot.org/uniprot/A0A5F4W1S3 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/9483:TARBP2 ^@ http://purl.uniprot.org/uniprot/U3BZA3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TARBP2 family.|||Cytoplasm|||Nucleus|||Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.|||Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC).|||perinuclear region http://togogenome.org/gene/9483:TIMM10B ^@ http://purl.uniprot.org/uniprot/F7AVF7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9483:POLR2G ^@ http://purl.uniprot.org/uniprot/U3DX33 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.|||DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/9483:NDUFV2 ^@ http://purl.uniprot.org/uniprot/U3DYH6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. http://togogenome.org/gene/9483:LOC100399525 ^@ http://purl.uniprot.org/uniprot/F7HZW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:KCNK9 ^@ http://purl.uniprot.org/uniprot/F6TNM6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane|||pH-dependent, voltage-insensitive, background potassium channel protein. http://togogenome.org/gene/9483:GPM6B ^@ http://purl.uniprot.org/uniprot/A0A2R8MIT5|||http://purl.uniprot.org/uniprot/A0A5F4WJL7|||http://purl.uniprot.org/uniprot/A0A5F4WK22|||http://purl.uniprot.org/uniprot/F6RKY6|||http://purl.uniprot.org/uniprot/F7I5V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/9483:SCG5 ^@ http://purl.uniprot.org/uniprot/F7GV17 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.|||Belongs to the 7B2 family.|||Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.|||Secreted http://togogenome.org/gene/9483:DARS1 ^@ http://purl.uniprot.org/uniprot/F6ZUR7 ^@ Function|||Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. http://togogenome.org/gene/9483:CLRN3 ^@ http://purl.uniprot.org/uniprot/F7I2G0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/9483:CMC2 ^@ http://purl.uniprot.org/uniprot/F6Z6C1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion http://togogenome.org/gene/9483:SERPINB12 ^@ http://purl.uniprot.org/uniprot/F7GMI6 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9483:AMIGO3 ^@ http://purl.uniprot.org/uniprot/U3EPB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. AMIGO family.|||Membrane http://togogenome.org/gene/9483:ZDHHC24 ^@ http://purl.uniprot.org/uniprot/U3EQW3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9483:TPST1 ^@ http://purl.uniprot.org/uniprot/F6PPZ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein sulfotransferase family.|||Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.|||Golgi apparatus membrane http://togogenome.org/gene/9483:FTHL17 ^@ http://purl.uniprot.org/uniprot/F7IIS6 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/9483:MGST2 ^@ http://purl.uniprot.org/uniprot/U3D6F3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:FMO4 ^@ http://purl.uniprot.org/uniprot/F7I9S6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9483:CHMP7 ^@ http://purl.uniprot.org/uniprot/U3DPV1 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9483:SCNM1 ^@ http://purl.uniprot.org/uniprot/B0KWB5 ^@ Subcellular Location Annotation ^@ Nucleus speckle|||nucleoplasm http://togogenome.org/gene/9483:UBE2E3 ^@ http://purl.uniprot.org/uniprot/F7CXA3 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9483:PARG ^@ http://purl.uniprot.org/uniprot/F7DP34 ^@ Similarity ^@ Belongs to the poly(ADP-ribose) glycohydrolase family. http://togogenome.org/gene/9483:MYO1B ^@ http://purl.uniprot.org/uniprot/A0A2R8MBT4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9483:CNNM1 ^@ http://purl.uniprot.org/uniprot/A0A8I3WRG8|||http://purl.uniprot.org/uniprot/A0A8I3XE90|||http://purl.uniprot.org/uniprot/F7I103 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ACDP family.|||Cell membrane|||Membrane|||Metal transporter. http://togogenome.org/gene/9483:CX3CR1 ^@ http://purl.uniprot.org/uniprot/F7I7I1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1.|||Membrane http://togogenome.org/gene/9483:HOATZ ^@ http://purl.uniprot.org/uniprot/A0A8I3W111|||http://purl.uniprot.org/uniprot/F6QYF5 ^@ Similarity ^@ Belongs to the HOATZ family. http://togogenome.org/gene/9483:AKAP9 ^@ http://purl.uniprot.org/uniprot/U3FQ11 ^@ Subcellular Location Annotation ^@ centrosome http://togogenome.org/gene/9483:LOC100415269 ^@ http://purl.uniprot.org/uniprot/B0VXC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:CA7 ^@ http://purl.uniprot.org/uniprot/F7B798 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9483:EXOSC3 ^@ http://purl.uniprot.org/uniprot/U3FVL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP40 family.|||Cytoplasm|||nucleolus http://togogenome.org/gene/9483:GNG10 ^@ http://purl.uniprot.org/uniprot/F7ESA3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9483:CYP3A5 ^@ http://purl.uniprot.org/uniprot/B1NL97 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9483:ATP6V1B1 ^@ http://purl.uniprot.org/uniprot/F7B6Z3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits. http://togogenome.org/gene/9483:CUL3 ^@ http://purl.uniprot.org/uniprot/F7GYK0 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9483:LOC108591240 ^@ http://purl.uniprot.org/uniprot/F7HQ77 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/9483:PTX3 ^@ http://purl.uniprot.org/uniprot/U3FG41 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:TMEM8B ^@ http://purl.uniprot.org/uniprot/U3CJE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:ST6GALNAC4 ^@ http://purl.uniprot.org/uniprot/F6ZK00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9483:LOC100405375 ^@ http://purl.uniprot.org/uniprot/F7FGR8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/9483:MID2 ^@ http://purl.uniprot.org/uniprot/U3B1I8|||http://purl.uniprot.org/uniprot/U3EWX9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRIM/RBCC family.|||Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.|||Nucleus|||cytoskeleton http://togogenome.org/gene/9483:TIGD2 ^@ http://purl.uniprot.org/uniprot/U3AZP8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:OSTC ^@ http://purl.uniprot.org/uniprot/F7HL75 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OSTC family.|||Component of the oligosaccharyltransferase (OST) complex.|||Membrane|||Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1. http://togogenome.org/gene/9483:DHRS11 ^@ http://purl.uniprot.org/uniprot/U3CDC2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9483:SEH1L ^@ http://purl.uniprot.org/uniprot/F7EUR5|||http://purl.uniprot.org/uniprot/U3CY94 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.|||Lysosome membrane|||kinetochore http://togogenome.org/gene/9483:ALG9 ^@ http://purl.uniprot.org/uniprot/U3DKC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:BEND6 ^@ http://purl.uniprot.org/uniprot/F6THU7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:MRFAP1 ^@ http://purl.uniprot.org/uniprot/F6QM18 ^@ Similarity ^@ Belongs to the MORF4 family-associated protein family. http://togogenome.org/gene/9483:TMEM126B ^@ http://purl.uniprot.org/uniprot/F7HZV3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:FGF20 ^@ http://purl.uniprot.org/uniprot/A0A7U3JW33 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9483:EXOSC1 ^@ http://purl.uniprot.org/uniprot/F6WV46 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:IFNB1 ^@ http://purl.uniprot.org/uniprot/A0A7R8C316 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9483:CDC42EP3 ^@ http://purl.uniprot.org/uniprot/U3BCL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/9483:LOC100385441 ^@ http://purl.uniprot.org/uniprot/A0A2R8MBM5|||http://purl.uniprot.org/uniprot/U3F7H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9483:CHRM2 ^@ http://purl.uniprot.org/uniprot/F7APE0|||http://purl.uniprot.org/uniprot/U3EXJ6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. http://togogenome.org/gene/9483:LHX5 ^@ http://purl.uniprot.org/uniprot/F7I4X9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:B4GALT1 ^@ http://purl.uniprot.org/uniprot/F7I1Z8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9483:LOC100895949 ^@ http://purl.uniprot.org/uniprot/A0A2R8PJM6 ^@ Function|||Subunit ^@ In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9483:LOC100410611 ^@ http://purl.uniprot.org/uniprot/Q6WN28|||http://purl.uniprot.org/uniprot/U3FQP9 ^@ Function|||Similarity|||Subunit|||Tissue Specificity ^@ Belongs to the globin family.|||Heterotetramer of two alpha chains and two beta chains.|||Involved in oxygen transport from the lung to the various peripheral tissues.|||Red blood cells. http://togogenome.org/gene/9483:LOC100398645 ^@ http://purl.uniprot.org/uniprot/A0A8I3X648 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9483:EXTL2 ^@ http://purl.uniprot.org/uniprot/F7G1W8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:GTF2E2 ^@ http://purl.uniprot.org/uniprot/U3B951 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFIIE beta subunit family.|||Nucleus|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.|||Tetramer of two alpha and two beta chains. http://togogenome.org/gene/9483:PIP4P1 ^@ http://purl.uniprot.org/uniprot/F7I551|||http://purl.uniprot.org/uniprot/U3FEW4 ^@ Function|||Subcellular Location Annotation ^@ Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane|||phagosome membrane http://togogenome.org/gene/9483:CADM1 ^@ http://purl.uniprot.org/uniprot/A0A2R8PKZ8|||http://purl.uniprot.org/uniprot/U3EZB7 ^@ Similarity ^@ Belongs to the nectin family. http://togogenome.org/gene/9483:AKIRIN1 ^@ http://purl.uniprot.org/uniprot/F7B8Z5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus http://togogenome.org/gene/9483:PARP6 ^@ http://purl.uniprot.org/uniprot/U3E0E5 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9483:CPA1 ^@ http://purl.uniprot.org/uniprot/F6WX16 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9483:CYP19A1 ^@ http://purl.uniprot.org/uniprot/F7HXX8|||http://purl.uniprot.org/uniprot/Q95M61 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Catalyzes the formation of aromatic C18 estrogens from C19 androgens.|||Membrane http://togogenome.org/gene/9483:PTAR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8MTV6|||http://purl.uniprot.org/uniprot/A0A8I3ZYE6|||http://purl.uniprot.org/uniprot/A0A8J8XIP4|||http://purl.uniprot.org/uniprot/F7HUT4 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family. http://togogenome.org/gene/9483:FAM162A ^@ http://purl.uniprot.org/uniprot/F6VDN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0389 family.|||Membrane http://togogenome.org/gene/9483:DNER ^@ http://purl.uniprot.org/uniprot/F7G2V2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:SSR4 ^@ http://purl.uniprot.org/uniprot/F7FX02 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-delta family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/9483:LHFPL6 ^@ http://purl.uniprot.org/uniprot/U3EXN1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:PON2 ^@ http://purl.uniprot.org/uniprot/F7D0R7 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit.|||Glycosylated. http://togogenome.org/gene/9483:CPLX3 ^@ http://purl.uniprot.org/uniprot/F6WRU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9483:SERPINB1 ^@ http://purl.uniprot.org/uniprot/F7ISC2 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9483:ASB7 ^@ http://purl.uniprot.org/uniprot/U3EV99 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9483:ZC3H12C ^@ http://purl.uniprot.org/uniprot/A0A8I3WP39 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/9483:GNAO1 ^@ http://purl.uniprot.org/uniprot/A0A2R8P4V7 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9483:GSTP1 ^@ http://purl.uniprot.org/uniprot/U3EHV9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GST superfamily. Pi family.|||Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.|||Cytoplasm|||Homodimer.|||Mitochondrion|||Nucleus http://togogenome.org/gene/9483:SCG3 ^@ http://purl.uniprot.org/uniprot/A0A8I3XBG4 ^@ Subcellular Location Annotation ^@ Membrane|||Secreted|||secretory vesicle membrane http://togogenome.org/gene/9483:MST1 ^@ http://purl.uniprot.org/uniprot/F6S5L7 ^@ Caution|||Similarity ^@ Belongs to the peptidase S1 family. Plasminogen subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:CD36 ^@ http://purl.uniprot.org/uniprot/U3BY47 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/9483:STING1 ^@ http://purl.uniprot.org/uniprot/F7HWC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STING family.|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Mitochondrion outer membrane|||autophagosome membrane|||perinuclear region http://togogenome.org/gene/9483:RPL23 ^@ http://purl.uniprot.org/uniprot/A0A2R8PA32 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/9483:SLC35A1 ^@ http://purl.uniprot.org/uniprot/U3BSW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:GRIA1 ^@ http://purl.uniprot.org/uniprot/F7HTC7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9483:MEPCE ^@ http://purl.uniprot.org/uniprot/U3E6A8 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/9483:CSTPP1 ^@ http://purl.uniprot.org/uniprot/U3FM37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSTPP1 family.|||cytoskeleton http://togogenome.org/gene/9483:CLPX ^@ http://purl.uniprot.org/uniprot/U3DAL1 ^@ Similarity ^@ Belongs to the ClpX chaperone family. http://togogenome.org/gene/9483:IL9 ^@ http://purl.uniprot.org/uniprot/F7HMS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-7/IL-9 family.|||Secreted http://togogenome.org/gene/9483:SLC5A1 ^@ http://purl.uniprot.org/uniprot/B0KWS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:SLC17A9 ^@ http://purl.uniprot.org/uniprot/A0A8I3WJT7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:LOC100393688 ^@ http://purl.uniprot.org/uniprot/B0KWF4 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/9483:PIAS3 ^@ http://purl.uniprot.org/uniprot/U3FA04 ^@ Similarity ^@ Belongs to the PIAS family. http://togogenome.org/gene/9483:GIMAP1 ^@ http://purl.uniprot.org/uniprot/F6Q1Z7 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9483:SPARCL1 ^@ http://purl.uniprot.org/uniprot/U3F1M7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPARC family.|||extracellular matrix http://togogenome.org/gene/9483:CD40LG ^@ http://purl.uniprot.org/uniprot/Q9BDN3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.|||Belongs to the tumor necrosis factor family.|||Cell membrane|||Cell surface|||Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity).|||Homotrimer (By similarity). Interacts with CD28 (By similarity). CD40 ligand, soluble form: Exists as either a monomer or a homotrimer (By similarity). Forms a ternary complex between CD40 and integrins for CD40-CD40LG signaling (By similarity).|||Secreted|||The soluble form derives from the membrane form by proteolytic processing. http://togogenome.org/gene/9483:ILDR1 ^@ http://purl.uniprot.org/uniprot/F7GPP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. LISCH7 family.|||Membrane|||tight junction http://togogenome.org/gene/9483:THEMIS ^@ http://purl.uniprot.org/uniprot/A0A8I3WY64 ^@ Similarity ^@ Belongs to the themis family. http://togogenome.org/gene/9483:HNRNPK ^@ http://purl.uniprot.org/uniprot/F7IK44|||http://purl.uniprot.org/uniprot/U3CKT0 ^@ Subcellular Location Annotation ^@ Cytoplasm|||nucleoplasm|||podosome http://togogenome.org/gene/9483:UTS2R ^@ http://purl.uniprot.org/uniprot/A0A2R8MIZ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.|||Membrane http://togogenome.org/gene/9483:CLDN9 ^@ http://purl.uniprot.org/uniprot/F7CV25 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9483:RECQL4 ^@ http://purl.uniprot.org/uniprot/F7GFQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RecQ subfamily.|||Nucleus http://togogenome.org/gene/9483:CDC42EP5 ^@ http://purl.uniprot.org/uniprot/B0VXJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/9483:DEFA4 ^@ http://purl.uniprot.org/uniprot/F6PJC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-defensin family.|||Secreted http://togogenome.org/gene/9483:GPRC5A ^@ http://purl.uniprot.org/uniprot/F7IJ74 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9483:PPP1R14B ^@ http://purl.uniprot.org/uniprot/F6Q451 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PP1 inhibitor family.|||Cytoplasm|||Inhibitor of PPP1CA. http://togogenome.org/gene/9483:TRIM14 ^@ http://purl.uniprot.org/uniprot/F7H1L9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRIM/RBCC family.|||Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:SLFN11 ^@ http://purl.uniprot.org/uniprot/F7E9W8 ^@ Similarity ^@ Belongs to the Schlafen family. Subgroup III subfamily. http://togogenome.org/gene/9483:ATG9A ^@ http://purl.uniprot.org/uniprot/F6RC33 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.|||Preautophagosomal structure membrane http://togogenome.org/gene/9483:SEMA4F ^@ http://purl.uniprot.org/uniprot/F7I7T5|||http://purl.uniprot.org/uniprot/F7IA44|||http://purl.uniprot.org/uniprot/U3BXV6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:LOC100389168 ^@ http://purl.uniprot.org/uniprot/A0A8I3X340 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9483:RFTN2 ^@ http://purl.uniprot.org/uniprot/F6PHM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the raftlin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:RAB3D ^@ http://purl.uniprot.org/uniprot/F7I8G8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/9483:PARP12 ^@ http://purl.uniprot.org/uniprot/F7F9E2 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9483:CLDN20 ^@ http://purl.uniprot.org/uniprot/A0A5F4W442 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9483:SAR1A ^@ http://purl.uniprot.org/uniprot/F6WCH0 ^@ Similarity ^@ Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/9483:POLR1A ^@ http://purl.uniprot.org/uniprot/F7H346 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta' chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/9483:ID3 ^@ http://purl.uniprot.org/uniprot/F7IIH1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:LGI1 ^@ http://purl.uniprot.org/uniprot/A0A2R8MNW8|||http://purl.uniprot.org/uniprot/F7A305 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9483:NDUFS2 ^@ http://purl.uniprot.org/uniprot/F7D5V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I 49 kDa subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:CALHM6 ^@ http://purl.uniprot.org/uniprot/F7IPY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9483:LETM1 ^@ http://purl.uniprot.org/uniprot/F7DVP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LETM1 family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9483:SLC16A2 ^@ http://purl.uniprot.org/uniprot/A0A8I3WZ05 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:IFI27L2 ^@ http://purl.uniprot.org/uniprot/F7I565 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFI6/IFI27 family.|||Membrane http://togogenome.org/gene/9483:EVA1B ^@ http://purl.uniprot.org/uniprot/F7GUT3 ^@ Similarity ^@ Belongs to the EVA1 family. http://togogenome.org/gene/9483:LGSN ^@ http://purl.uniprot.org/uniprot/A0A5F4W1T8|||http://purl.uniprot.org/uniprot/F7DFP2 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/9483:DCTN5 ^@ http://purl.uniprot.org/uniprot/U3CVW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.|||cytoskeleton http://togogenome.org/gene/9483:PDCL3 ^@ http://purl.uniprot.org/uniprot/F7G7I6 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9483:LOC100387657 ^@ http://purl.uniprot.org/uniprot/F7GLL2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit C family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm|||Phosphorylated. Phosphorylation is enhanced upon serum stimulation. http://togogenome.org/gene/9483:MAP2K4 ^@ http://purl.uniprot.org/uniprot/A0A2R8MIZ6|||http://purl.uniprot.org/uniprot/A0A8I3WWX8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:SAMM50 ^@ http://purl.uniprot.org/uniprot/U3DML6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAM50/omp85 family.|||Mitochondrion outer membrane http://togogenome.org/gene/9483:VPS52 ^@ http://purl.uniprot.org/uniprot/F7IGV6 ^@ Similarity ^@ Belongs to the VPS52 family. http://togogenome.org/gene/9483:KIF2C ^@ http://purl.uniprot.org/uniprot/F6PQV2 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9483:PAFAH1B1 ^@ http://purl.uniprot.org/uniprot/F7HWL4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat LIS1/nudF family.|||Can self-associate. Interacts with DCX, dynein, dynactin, IQGAP1, KATNB1, NDE1, NDEL1, NUDC and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling. Component of cytosolic PAF-AH IB, which is composed of PAFAH1B1 (alpha), PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits. Trimer formation is not essential for the catalytic activity of the enzyme which is contributed solely by the PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits.|||Dimerization mediated by the LisH domain may be required to activate dynein.|||Nucleus membrane|||Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position.|||centrosome|||cytoskeleton|||spindle http://togogenome.org/gene/9483:LRTOMT ^@ http://purl.uniprot.org/uniprot/F6UJ98 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. http://togogenome.org/gene/9483:NTMT2 ^@ http://purl.uniprot.org/uniprot/F7FX50 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. NTM1 family. http://togogenome.org/gene/9483:ADH4 ^@ http://purl.uniprot.org/uniprot/A0A2R8MBZ6 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/9483:COMTD1 ^@ http://purl.uniprot.org/uniprot/F6X318 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. http://togogenome.org/gene/9483:FNTA ^@ http://purl.uniprot.org/uniprot/F7H177 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family. http://togogenome.org/gene/9483:VPS26A ^@ http://purl.uniprot.org/uniprot/F7GXC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS26 family.|||Endosome http://togogenome.org/gene/9483:SSTR1 ^@ http://purl.uniprot.org/uniprot/U3EYR3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9483:PSMB4 ^@ http://purl.uniprot.org/uniprot/B0KWC6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1B family.|||Cytoplasm|||Non-catalytic component of the proteasome.|||Nucleus http://togogenome.org/gene/9483:RPS27 ^@ http://purl.uniprot.org/uniprot/B0VXF6 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9483:COX8C ^@ http://purl.uniprot.org/uniprot/A0A8I3WL11 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIII family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9483:SNX2 ^@ http://purl.uniprot.org/uniprot/F7IH18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome membrane|||Endosome membrane|||Membrane|||lamellipodium http://togogenome.org/gene/9483:TM6SF1 ^@ http://purl.uniprot.org/uniprot/U3CXX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TM6SF family.|||Membrane http://togogenome.org/gene/9483:SLC27A1 ^@ http://purl.uniprot.org/uniprot/F7B110 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9483:METTL6 ^@ http://purl.uniprot.org/uniprot/U3CI44 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/9483:LOC100406557 ^@ http://purl.uniprot.org/uniprot/A0A8I3WMT9 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9483:TM4SF1 ^@ http://purl.uniprot.org/uniprot/F6S9T4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9483:SIGMAR1 ^@ http://purl.uniprot.org/uniprot/F6YPR0|||http://purl.uniprot.org/uniprot/U3DT67 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ERG2 family.|||Cell junction|||Cytoplasmic vesicle|||Endoplasmic reticulum membrane|||Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.|||Homotrimer.|||Lipid droplet|||Membrane|||Nucleus envelope|||Nucleus inner membrane|||Nucleus outer membrane|||Postsynaptic density membrane|||The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.|||Vesicle|||growth cone http://togogenome.org/gene/9483:AMZ2 ^@ http://purl.uniprot.org/uniprot/F7FPH4 ^@ Function|||Similarity ^@ Belongs to the peptidase M54 family.|||Probable zinc metalloprotease. http://togogenome.org/gene/9483:TMEM70 ^@ http://purl.uniprot.org/uniprot/F7C1U3 ^@ Similarity ^@ Belongs to the TMEM70 family. http://togogenome.org/gene/9483:RND3 ^@ http://purl.uniprot.org/uniprot/F7HJC5 ^@ Function ^@ Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. http://togogenome.org/gene/9483:LOC100403511 ^@ http://purl.uniprot.org/uniprot/F6Y4Z0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Golgi pH regulator (TC 1.A.38) family.|||Membrane http://togogenome.org/gene/9483:PSMD11 ^@ http://purl.uniprot.org/uniprot/F7HPV3 ^@ Similarity ^@ Belongs to the proteasome subunit S9 family. http://togogenome.org/gene/9483:CHMP5 ^@ http://purl.uniprot.org/uniprot/F7I3H4 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9483:MFSD4A ^@ http://purl.uniprot.org/uniprot/U3B6V7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:RNF34 ^@ http://purl.uniprot.org/uniprot/F7IKY3 ^@ Subcellular Location Annotation ^@ Cell membrane|||cytosol http://togogenome.org/gene/9483:HYI ^@ http://purl.uniprot.org/uniprot/F7GQR5 ^@ Function|||Similarity ^@ Belongs to the hyi family.|||Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde). http://togogenome.org/gene/9483:TACC2 ^@ http://purl.uniprot.org/uniprot/U3EDY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACC family.|||centrosome http://togogenome.org/gene/9483:TMEM199 ^@ http://purl.uniprot.org/uniprot/F7HX53 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:TMEM33 ^@ http://purl.uniprot.org/uniprot/F7F832 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PER33/POM33 family.|||Membrane http://togogenome.org/gene/9483:ARHGEF12 ^@ http://purl.uniprot.org/uniprot/A0A5F4VTL2|||http://purl.uniprot.org/uniprot/U3D1J4|||http://purl.uniprot.org/uniprot/U3EDT1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Membrane http://togogenome.org/gene/9483:TRPC3 ^@ http://purl.uniprot.org/uniprot/U3FM83 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:IL6 ^@ http://purl.uniprot.org/uniprot/Q0Z973 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-6 superfamily.|||Secreted http://togogenome.org/gene/9483:APH1B ^@ http://purl.uniprot.org/uniprot/U3BNX4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the APH-1 family.|||Component of the gamma-secretase complex.|||Membrane|||Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. http://togogenome.org/gene/9483:PFN1 ^@ http://purl.uniprot.org/uniprot/F6PID5 ^@ Similarity ^@ Belongs to the profilin family. http://togogenome.org/gene/9483:EFEMP2 ^@ http://purl.uniprot.org/uniprot/U3CJ36 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:COG1 ^@ http://purl.uniprot.org/uniprot/F6XYA7 ^@ Similarity ^@ Belongs to the COG1 family. http://togogenome.org/gene/9483:PPARG ^@ http://purl.uniprot.org/uniprot/F6T9U1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Cytoplasm|||Heterodimer with other nuclear receptors.|||Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.|||Nucleus http://togogenome.org/gene/9483:NAE1 ^@ http://purl.uniprot.org/uniprot/U3F0P7 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.|||Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. http://togogenome.org/gene/9483:GSTO1 ^@ http://purl.uniprot.org/uniprot/U3DX59 ^@ Function|||Similarity ^@ Belongs to the GST superfamily. Omega family.|||Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). http://togogenome.org/gene/9483:GRID2 ^@ http://purl.uniprot.org/uniprot/F7E4U9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9483:ZGPAT ^@ http://purl.uniprot.org/uniprot/F7B996 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with CHD4/Mi-2; the interaction is direct.|||Nucleus http://togogenome.org/gene/9483:LOC100402350 ^@ http://purl.uniprot.org/uniprot/F7GGF4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:PROZ ^@ http://purl.uniprot.org/uniprot/F7H321 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:MS4A7 ^@ http://purl.uniprot.org/uniprot/F6V8V9 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9483:CFAP300 ^@ http://purl.uniprot.org/uniprot/A0A2R8PIC0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP300 family.|||Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.|||Cytoplasm http://togogenome.org/gene/9483:ZWILCH ^@ http://purl.uniprot.org/uniprot/A0A8J8XJB2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ZWILCH family.|||Component of the RZZ complex.|||Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.|||kinetochore http://togogenome.org/gene/9483:ITGB1 ^@ http://purl.uniprot.org/uniprot/U3BF89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:CRKL ^@ http://purl.uniprot.org/uniprot/F7HYH0 ^@ Similarity ^@ Belongs to the CRK family. http://togogenome.org/gene/9483:UST ^@ http://purl.uniprot.org/uniprot/U3DQZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 3 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:PRSS12 ^@ http://purl.uniprot.org/uniprot/F7ERX9 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.|||Secreted http://togogenome.org/gene/9483:DDX1 ^@ http://purl.uniprot.org/uniprot/U3D3H9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DDX1 subfamily.|||Belongs to the TRIM/RBCC family.|||Cytoplasmic granule|||Nucleus|||RNA helicase.|||The helicase domain is involved in the stimulation of RELA transcriptional activity. http://togogenome.org/gene/9483:CKMT2 ^@ http://purl.uniprot.org/uniprot/F7G223 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/9483:SAE1 ^@ http://purl.uniprot.org/uniprot/F6QHC3|||http://purl.uniprot.org/uniprot/U3C0S2 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/9483:AKR1C1 ^@ http://purl.uniprot.org/uniprot/U3FQT3 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9483:HEATR5B ^@ http://purl.uniprot.org/uniprot/F7CXW2 ^@ Similarity ^@ Belongs to the HEATR5 family. http://togogenome.org/gene/9483:EID1 ^@ http://purl.uniprot.org/uniprot/F7GI85 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:LOC100408081 ^@ http://purl.uniprot.org/uniprot/A0A2R8MGA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:UBP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8M7A3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus http://togogenome.org/gene/9483:PAX6 ^@ http://purl.uniprot.org/uniprot/F6QG77 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the paired homeobox family.|||Interacts with KDM5B.|||Nucleus|||Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs. http://togogenome.org/gene/9483:FSD1L ^@ http://purl.uniprot.org/uniprot/U3D2E0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Nucleus http://togogenome.org/gene/9483:PPP1R21 ^@ http://purl.uniprot.org/uniprot/F7FNC9 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9483:NELFCD ^@ http://purl.uniprot.org/uniprot/F7HUP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NELF-D family.|||Nucleus http://togogenome.org/gene/9483:INHA ^@ http://purl.uniprot.org/uniprot/B0KWJ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.|||Secreted http://togogenome.org/gene/9483:AASDHPPT ^@ http://purl.uniprot.org/uniprot/U3FNY9 ^@ Similarity ^@ Belongs to the P-Pant transferase superfamily. AcpS family. http://togogenome.org/gene/9483:CAVIN1 ^@ http://purl.uniprot.org/uniprot/F6U9J5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/9483:HADH ^@ http://purl.uniprot.org/uniprot/U3ERY1 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/9483:CHAC2 ^@ http://purl.uniprot.org/uniprot/A0A5F4WMD6 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.|||Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. http://togogenome.org/gene/9483:NSFL1C ^@ http://purl.uniprot.org/uniprot/U3CGN9 ^@ Subcellular Location Annotation|||Subunit ^@ Golgi stack|||Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Binds ubiquitin and mono-ubiquitinated proteins via its N-terminal UBA-like domain when bound to VCP. http://togogenome.org/gene/9483:SLC25A15 ^@ http://purl.uniprot.org/uniprot/U3CT12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9483:EDC4 ^@ http://purl.uniprot.org/uniprot/A0A5K1UHY1|||http://purl.uniprot.org/uniprot/U3E1X6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat EDC4 family.|||P-body http://togogenome.org/gene/9483:UBALD1 ^@ http://purl.uniprot.org/uniprot/A0A2R8MPE1 ^@ Similarity ^@ Belongs to the UBALD family. http://togogenome.org/gene/9483:ARGLU1 ^@ http://purl.uniprot.org/uniprot/F7FFN5 ^@ Similarity ^@ Belongs to the UPF0430 family. http://togogenome.org/gene/9483:MMS22L ^@ http://purl.uniprot.org/uniprot/A0A8I3X025 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MMS22 family. MMS22L subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/9483:SPACA3 ^@ http://purl.uniprot.org/uniprot/F7I955 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9483:SUB1 ^@ http://purl.uniprot.org/uniprot/F7I1C7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transcriptional coactivator PC4 family.|||General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).|||Homodimer. Interacts with CSTF2.|||Nucleus http://togogenome.org/gene/9483:CDH2 ^@ http://purl.uniprot.org/uniprot/B0KW95|||http://purl.uniprot.org/uniprot/F7HZT3|||http://purl.uniprot.org/uniprot/U3FY48 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells (By similarity). Required for proper neurite branching. Required for pre- and postsynaptic organization (By similarity). CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.|||Cell junction|||Cell membrane|||Cell surface|||Cleaved by MMP24. Ectodomain cleavage leads to the generation of a soluble 90 kDa N-terminal soluble fragment and a 45 kDa membrane-bound C-terminal fragment 1 (CTF1), which is further cleaved by gamma-secretase into a 35 kDa (By similarity). Cleavage in neural stem cells by MMP24 affects CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate neural stem cell quiescence (By similarity).|||Homodimer (via extracellular region). Can also form heterodimers with other cadherins (via extracellular region). Dimerization occurs in trans, i.e. with a cadherin chain from another cell (By similarity). Interacts with CDCP1 (By similarity). Interacts with PCDH8; this complex may also include TAOK2 (By similarity). The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway (By similarity). Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. May interact with OBSCN (via protein kinase domain 2) (By similarity). Interacts with FBXO45 (By similarity).|||Membrane|||Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. Calcium-binding sites are occupied sequentially in the order of site 3, then site 2 and site 1.|||adherens junction|||desmosome|||sarcolemma http://togogenome.org/gene/9483:PTGR2 ^@ http://purl.uniprot.org/uniprot/A0A8I3WNV1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADP-dependent oxidoreductase L4BD family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9483:TPM2 ^@ http://purl.uniprot.org/uniprot/U3CKE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9483:ACTL8 ^@ http://purl.uniprot.org/uniprot/F7HR35 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9483:FBXO32 ^@ http://purl.uniprot.org/uniprot/U3ERG3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:NAA10 ^@ http://purl.uniprot.org/uniprot/B0KWW1 ^@ Similarity ^@ Belongs to the acetyltransferase family. ARD1 subfamily. http://togogenome.org/gene/9483:EPC2 ^@ http://purl.uniprot.org/uniprot/A0A5F4VS20|||http://purl.uniprot.org/uniprot/F7IQD8|||http://purl.uniprot.org/uniprot/U3CP32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enhancer of polycomb family.|||Nucleus http://togogenome.org/gene/9483:CSNK1D ^@ http://purl.uniprot.org/uniprot/F6PU42|||http://purl.uniprot.org/uniprot/F6QGM4|||http://purl.uniprot.org/uniprot/F6QSB7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:CLCA1 ^@ http://purl.uniprot.org/uniprot/F7CTH0 ^@ Similarity ^@ Belongs to the CLCR family. http://togogenome.org/gene/9483:GH1 ^@ http://purl.uniprot.org/uniprot/A0AAU6|||http://purl.uniprot.org/uniprot/Q9GMB3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues (By similarity).|||Secreted http://togogenome.org/gene/9483:ITGA3 ^@ http://purl.uniprot.org/uniprot/F6S164|||http://purl.uniprot.org/uniprot/F7GGD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9483:LOC100894532 ^@ http://purl.uniprot.org/uniprot/B0VXC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:MCEE ^@ http://purl.uniprot.org/uniprot/A0A5F4W3C0 ^@ Similarity ^@ Belongs to the methylmalonyl-CoA epimerase family. http://togogenome.org/gene/9483:IRF3 ^@ http://purl.uniprot.org/uniprot/F7HB60 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:WSCD2 ^@ http://purl.uniprot.org/uniprot/U3CR93 ^@ Function|||Similarity ^@ Belongs to the WSCD family.|||Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans. http://togogenome.org/gene/9483:LGI4 ^@ http://purl.uniprot.org/uniprot/U3BGF6 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9483:TMED1 ^@ http://purl.uniprot.org/uniprot/F7D6C1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9483:CHMP3 ^@ http://purl.uniprot.org/uniprot/F7GN92 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9483:ASB15 ^@ http://purl.uniprot.org/uniprot/A0A8I3W2Y7|||http://purl.uniprot.org/uniprot/U3DDH4 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9483:COR52P3 ^@ http://purl.uniprot.org/uniprot/B0VXD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:MTMR12 ^@ http://purl.uniprot.org/uniprot/A0A8I3XAX9|||http://purl.uniprot.org/uniprot/U3EEE5 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9483:SEMA6D ^@ http://purl.uniprot.org/uniprot/F7H9T7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:LOC100894628 ^@ http://purl.uniprot.org/uniprot/F7IQR5 ^@ Similarity ^@ Belongs to the UQCC4 family. http://togogenome.org/gene/9483:TRIM17 ^@ http://purl.uniprot.org/uniprot/F7AML3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRIM/RBCC family.|||Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:CRYBB2 ^@ http://purl.uniprot.org/uniprot/U3F629 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9483:RPL30 ^@ http://purl.uniprot.org/uniprot/F6WQV8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/9483:LOC103788995 ^@ http://purl.uniprot.org/uniprot/F7H071 ^@ Similarity ^@ Belongs to the cornifin (SPRR) family. http://togogenome.org/gene/9483:GCHFR ^@ http://purl.uniprot.org/uniprot/F7IKX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GFRP family.|||Membrane|||Nucleus membrane|||cytosol http://togogenome.org/gene/9483:TPPP ^@ http://purl.uniprot.org/uniprot/U3C144 ^@ Similarity ^@ Belongs to the TPPP family. http://togogenome.org/gene/9483:PYCR1 ^@ http://purl.uniprot.org/uniprot/A0A8I3X6M6 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/9483:YTHDF1 ^@ http://purl.uniprot.org/uniprot/F7GJA0 ^@ Function|||Similarity ^@ Belongs to the YTHDF family.|||Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. http://togogenome.org/gene/9483:FAM174A ^@ http://purl.uniprot.org/uniprot/F7IRI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM174 family.|||Membrane http://togogenome.org/gene/9483:CMTM3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XIN1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:KITLG ^@ http://purl.uniprot.org/uniprot/F7G0W2|||http://purl.uniprot.org/uniprot/F7G0Y4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCF family.|||Cytoplasm|||Homodimer, non-covalently linked.|||Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.|||Secreted|||filopodium|||lamellipodium http://togogenome.org/gene/9483:DR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8MT44 ^@ Similarity ^@ Belongs to the NC2 beta/DR1 family. http://togogenome.org/gene/9483:FOXP1 ^@ http://purl.uniprot.org/uniprot/A0A8I3W5Y5|||http://purl.uniprot.org/uniprot/U3FVN3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:ERGIC3 ^@ http://purl.uniprot.org/uniprot/B0KWM1|||http://purl.uniprot.org/uniprot/F7EQK7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/9483:RNF185 ^@ http://purl.uniprot.org/uniprot/F7HCL9 ^@ Domain|||Function|||Subcellular Location Annotation ^@ E3 ubiquitin-protein ligase.|||Endoplasmic reticulum membrane|||Mitochondrion membrane|||The RING-type zinc finger domain is responsible for E3 ligase activity. http://togogenome.org/gene/9483:CAJA-E ^@ http://purl.uniprot.org/uniprot/A0FJB5 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9483:TRIM68 ^@ http://purl.uniprot.org/uniprot/U3EE72 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRIM/RBCC family.|||Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:NOP14 ^@ http://purl.uniprot.org/uniprot/F7IE93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP14 family.|||Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.|||nucleolus http://togogenome.org/gene/9483:ATXN3 ^@ http://purl.uniprot.org/uniprot/F6SV02 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:TSPYL1 ^@ http://purl.uniprot.org/uniprot/U3BLB6 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9483:GPR108 ^@ http://purl.uniprot.org/uniprot/U3EP34 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:CZIB ^@ http://purl.uniprot.org/uniprot/F7IHX7 ^@ Similarity ^@ Belongs to the UPF0587 family. http://togogenome.org/gene/9483:MGME1 ^@ http://purl.uniprot.org/uniprot/F7II48|||http://purl.uniprot.org/uniprot/U3F3A0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGME1 family.|||Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair.|||Mitochondrion http://togogenome.org/gene/9483:MPC1 ^@ http://purl.uniprot.org/uniprot/A0A8I3XDU5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9483:CCDC181 ^@ http://purl.uniprot.org/uniprot/U3DQV4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC181 family.|||Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.|||cytoskeleton|||flagellum http://togogenome.org/gene/9483:FPGS ^@ http://purl.uniprot.org/uniprot/F6QU94 ^@ Cofactor|||Function|||Similarity ^@ A monovalent cation.|||Belongs to the folylpolyglutamate synthase family.|||Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. http://togogenome.org/gene/9483:ABITRAM ^@ http://purl.uniprot.org/uniprot/U3FJK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABITRAM family.|||growth cone|||lamellipodium http://togogenome.org/gene/9483:PDSS2 ^@ http://purl.uniprot.org/uniprot/A0A2R8P504 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9483:RETREG1 ^@ http://purl.uniprot.org/uniprot/F7ECF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RETREG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:STRA6 ^@ http://purl.uniprot.org/uniprot/F7BJF2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9483:NFIL3 ^@ http://purl.uniprot.org/uniprot/F7II13 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. Protects pro-B cells from programmed cell death.|||Belongs to the bZIP family. NFIL3 subfamily.|||Homodimer. Binds DNA as a dimer.|||Nucleus http://togogenome.org/gene/9483:FAM3A ^@ http://purl.uniprot.org/uniprot/B0KWT8|||http://purl.uniprot.org/uniprot/U3E9S8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/9483:CACNA2D3 ^@ http://purl.uniprot.org/uniprot/F7IIU4 ^@ Similarity ^@ Belongs to the calcium channel subunit alpha-2/delta family. http://togogenome.org/gene/9483:HEBP1 ^@ http://purl.uniprot.org/uniprot/F7IJ77 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/9483:LOC108589342 ^@ http://purl.uniprot.org/uniprot/A0A8I3WMQ9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/9483:MANBA ^@ http://purl.uniprot.org/uniprot/A0A5F4W139 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 2 family.|||Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.|||Lysosome|||Monomer. http://togogenome.org/gene/9483:RO60 ^@ http://purl.uniprot.org/uniprot/F6ZHA8|||http://purl.uniprot.org/uniprot/U3FLM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ro 60 kDa family.|||Cytoplasm http://togogenome.org/gene/9483:MPPED2 ^@ http://purl.uniprot.org/uniprot/U3BEC4 ^@ Similarity ^@ Belongs to the UPF0046 family. http://togogenome.org/gene/9483:MYOD1 ^@ http://purl.uniprot.org/uniprot/U3FGJ7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.|||Nucleus http://togogenome.org/gene/9483:AZIN2 ^@ http://purl.uniprot.org/uniprot/F7I7B9 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/9483:LCAT ^@ http://purl.uniprot.org/uniprot/A0A8I3WUV1 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9483:ORC2 ^@ http://purl.uniprot.org/uniprot/U3CG13 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC2 family.|||Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.|||Component of the origin recognition complex (ORC).|||Nucleus http://togogenome.org/gene/9483:CEBPZ ^@ http://purl.uniprot.org/uniprot/U3F1A1 ^@ Similarity ^@ Belongs to the CBF/MAK21 family. http://togogenome.org/gene/9483:LOC100409740 ^@ http://purl.uniprot.org/uniprot/A0A8I4A680 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9483:ZMYND10 ^@ http://purl.uniprot.org/uniprot/F7GCB1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the ZMYND10 family.|||Dynein axonemal particle|||Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.|||centriolar satellite http://togogenome.org/gene/9483:WWOX ^@ http://purl.uniprot.org/uniprot/U3FE30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm|||Golgi apparatus|||Lysosome|||Mitochondrion http://togogenome.org/gene/9483:TMEM38B ^@ http://purl.uniprot.org/uniprot/F7HYQ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM38 family.|||Membrane|||Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. http://togogenome.org/gene/9483:PSENEN ^@ http://purl.uniprot.org/uniprot/F7DH46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PEN-2 family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9483:S100A16 ^@ http://purl.uniprot.org/uniprot/F7AMA4 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9483:TRAM1 ^@ http://purl.uniprot.org/uniprot/F7INC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAM family.|||Membrane http://togogenome.org/gene/9483:ADH7 ^@ http://purl.uniprot.org/uniprot/A0A5K1TXR1 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/9483:GIMAP4 ^@ http://purl.uniprot.org/uniprot/F6XVX4 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9483:KAT6B ^@ http://purl.uniprot.org/uniprot/A0A5F4W2A5 ^@ Similarity ^@ Belongs to the MYST (SAS/MOZ) family. http://togogenome.org/gene/9483:RBFOX3 ^@ http://purl.uniprot.org/uniprot/F7I9Y0 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||RNA-binding protein that regulates alternative splicing events. http://togogenome.org/gene/9483:SGF29 ^@ http://purl.uniprot.org/uniprot/U3FNH1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:NPHS2 ^@ http://purl.uniprot.org/uniprot/F7G7A4 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/9483:ACAT2 ^@ http://purl.uniprot.org/uniprot/F7H488 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/9483:TMEM200A ^@ http://purl.uniprot.org/uniprot/F7HRG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM200 family.|||Membrane http://togogenome.org/gene/9483:MAN2A2 ^@ http://purl.uniprot.org/uniprot/F7A987 ^@ Cofactor|||Similarity ^@ Belongs to the glycosyl hydrolase 38 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9483:ATL3 ^@ http://purl.uniprot.org/uniprot/F7CPC5 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9483:SDHB ^@ http://purl.uniprot.org/uniprot/F7IQK8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster.|||Binds 1 [3Fe-4S] cluster.|||Binds 1 [4Fe-4S] cluster.|||Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/9483:CAP1 ^@ http://purl.uniprot.org/uniprot/F7I0Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAP family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:FASLG ^@ http://purl.uniprot.org/uniprot/F7I0V8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tumor necrosis factor family.|||Cell membrane|||Cytoplasmic form induces gene transcription inhibition.|||Cytoplasmic vesicle lumen|||Lysosome lumen|||Nucleus|||Secreted http://togogenome.org/gene/9483:PAX3 ^@ http://purl.uniprot.org/uniprot/F7BBQ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the paired homeobox family.|||Interacts with KDM5B.|||Nucleus|||Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs. http://togogenome.org/gene/9483:PCBD1 ^@ http://purl.uniprot.org/uniprot/A0A2R8MHV7|||http://purl.uniprot.org/uniprot/F7GPT5 ^@ Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family. http://togogenome.org/gene/9483:NTF4 ^@ http://purl.uniprot.org/uniprot/F7HA42 ^@ Similarity ^@ Belongs to the NGF-beta family. http://togogenome.org/gene/9483:DERL1 ^@ http://purl.uniprot.org/uniprot/F6U3W9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Membrane http://togogenome.org/gene/9483:CRPPA ^@ http://purl.uniprot.org/uniprot/A0A2R8P6J5|||http://purl.uniprot.org/uniprot/A0A8I3W7B7|||http://purl.uniprot.org/uniprot/A0A8I3WGM6|||http://purl.uniprot.org/uniprot/A0A8I3WNV3|||http://purl.uniprot.org/uniprot/F6YEP4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.|||Homodimer.|||cytosol http://togogenome.org/gene/9483:FOXO1 ^@ http://purl.uniprot.org/uniprot/U3FDL3 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9483:DDX6 ^@ http://purl.uniprot.org/uniprot/F7A1X2 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9483:FDFT1 ^@ http://purl.uniprot.org/uniprot/F6TRY2 ^@ Function|||Similarity ^@ Belongs to the phytoene/squalene synthase family.|||Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. http://togogenome.org/gene/9483:UBE2A ^@ http://purl.uniprot.org/uniprot/F6SPE3 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9483:PGAP1 ^@ http://purl.uniprot.org/uniprot/U3CFJ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI inositol-deacylase family.|||Endoplasmic reticulum membrane|||Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.|||Membrane http://togogenome.org/gene/9483:AFF1 ^@ http://purl.uniprot.org/uniprot/U3E6U6|||http://purl.uniprot.org/uniprot/U3FG32 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/9483:INIP ^@ http://purl.uniprot.org/uniprot/F7H151 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SOSS-C family.|||Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).|||Component of the SOSS complex.|||Nucleus http://togogenome.org/gene/9483:PSMC6 ^@ http://purl.uniprot.org/uniprot/F6X828 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9483:PLK4 ^@ http://purl.uniprot.org/uniprot/F7E1H1|||http://purl.uniprot.org/uniprot/U3D9B8 ^@ Subcellular Location Annotation ^@ Cleavage furrow|||centriole http://togogenome.org/gene/9483:SF3B4 ^@ http://purl.uniprot.org/uniprot/F7GK55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3B4 family.|||Nucleus http://togogenome.org/gene/9483:CNFN ^@ http://purl.uniprot.org/uniprot/F7FLV5 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/9483:NODAL ^@ http://purl.uniprot.org/uniprot/F7I2K8 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9483:AGA ^@ http://purl.uniprot.org/uniprot/U3CEY9 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/9483:TOP1 ^@ http://purl.uniprot.org/uniprot/F6STR2 ^@ Function|||Similarity ^@ Belongs to the type IB topoisomerase family.|||Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/9483:HECTD1 ^@ http://purl.uniprot.org/uniprot/F7HZ46|||http://purl.uniprot.org/uniprot/U3BSJ6 ^@ Function|||Similarity ^@ Belongs to the UPL family. K-HECT subfamily.|||E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. http://togogenome.org/gene/9483:MPI ^@ http://purl.uniprot.org/uniprot/U3CWX3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the mannose-6-phosphate isomerase type 1 family.|||Binds 1 zinc ion per subunit.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/9483:GALNT5 ^@ http://purl.uniprot.org/uniprot/A0A5F4WAB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:RPL27A ^@ http://purl.uniprot.org/uniprot/F6S6U2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/9483:TNFRSF1A ^@ http://purl.uniprot.org/uniprot/F6UYQ7 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:CSAD ^@ http://purl.uniprot.org/uniprot/A0A8I4A5Y3 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/9483:TMEM150C ^@ http://purl.uniprot.org/uniprot/F7BRN5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:RPRD1A ^@ http://purl.uniprot.org/uniprot/F7GW04 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the RNA polymerase II complex.|||Belongs to the UPF0400 (RTT103) family.|||Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.|||Nucleus http://togogenome.org/gene/9483:RICTOR ^@ http://purl.uniprot.org/uniprot/F7HVJ0|||http://purl.uniprot.org/uniprot/U3DS95 ^@ Similarity ^@ Belongs to the RICTOR family. http://togogenome.org/gene/9483:THYN1 ^@ http://purl.uniprot.org/uniprot/F7CZ83 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. http://togogenome.org/gene/9483:TUBA4A ^@ http://purl.uniprot.org/uniprot/F7HZP3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9483:RPS19 ^@ http://purl.uniprot.org/uniprot/F7DXF3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS19 family. http://togogenome.org/gene/9483:SEC23A ^@ http://purl.uniprot.org/uniprot/U3CYE8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9483:NPY ^@ http://purl.uniprot.org/uniprot/F7HVB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Secreted http://togogenome.org/gene/9483:FOXP2 ^@ http://purl.uniprot.org/uniprot/F7IF16 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:FZD7 ^@ http://purl.uniprot.org/uniprot/F7I3D1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:C1D ^@ http://purl.uniprot.org/uniprot/F7HJF4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the C1D family.|||Cytoplasm|||Monomer and homodimer.|||Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.|||nucleolus http://togogenome.org/gene/9483:AMER1 ^@ http://purl.uniprot.org/uniprot/F7GVN4 ^@ Similarity ^@ Belongs to the Amer family. http://togogenome.org/gene/9483:FADS3 ^@ http://purl.uniprot.org/uniprot/U3B9H6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:GABRA4 ^@ http://purl.uniprot.org/uniprot/A0A8I3WPF1|||http://purl.uniprot.org/uniprot/F7IFW0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9483:LOC100410248 ^@ http://purl.uniprot.org/uniprot/B0VXB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:IREB2 ^@ http://purl.uniprot.org/uniprot/F6T5R8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Cytoplasm http://togogenome.org/gene/9483:NLGN3 ^@ http://purl.uniprot.org/uniprot/F7DYQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:SPC24 ^@ http://purl.uniprot.org/uniprot/F7HYV4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the SPC24 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/9483:RUSF1 ^@ http://purl.uniprot.org/uniprot/U3E5E9 ^@ Similarity ^@ Belongs to the RUS1 family. http://togogenome.org/gene/9483:EMP1 ^@ http://purl.uniprot.org/uniprot/F7ILG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/9483:FGF5 ^@ http://purl.uniprot.org/uniprot/F7DBG3|||http://purl.uniprot.org/uniprot/F7G2W7 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9483:CUL4B ^@ http://purl.uniprot.org/uniprot/A0A8I3WVL3|||http://purl.uniprot.org/uniprot/A0A8I3ZYC6 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9483:SETD7 ^@ http://purl.uniprot.org/uniprot/U3AWL6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.|||Chromosome|||Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.|||Nucleus http://togogenome.org/gene/9483:LOC100407409 ^@ http://purl.uniprot.org/uniprot/A0A2R8M558 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9483:LOC100406994 ^@ http://purl.uniprot.org/uniprot/A0A5F4VRT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:CLUAP1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XFW6|||http://purl.uniprot.org/uniprot/F7HDE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLUAP1 family.|||cilium http://togogenome.org/gene/9483:EIF4A1 ^@ http://purl.uniprot.org/uniprot/U3DYJ0 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family. eIF4A subfamily.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9483:LOC100399755 ^@ http://purl.uniprot.org/uniprot/Q95MG6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Phosphorylated on the C-terminal cytoplasmic tail.|||Receptor for gonadotropin releasing hormone II (GnRH II). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9483:ERG ^@ http://purl.uniprot.org/uniprot/A0A2R8M9X4|||http://purl.uniprot.org/uniprot/A0A2R8PEF7|||http://purl.uniprot.org/uniprot/F7F2B8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9483:MED18 ^@ http://purl.uniprot.org/uniprot/F7HVT1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 18 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9483:H1F0 ^@ http://purl.uniprot.org/uniprot/F7IAQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9483:OR2T4 ^@ http://purl.uniprot.org/uniprot/F6TMH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:ACER2 ^@ http://purl.uniprot.org/uniprot/F7IBP9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:LOC100390297 ^@ http://purl.uniprot.org/uniprot/B0VX93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:KCTD10 ^@ http://purl.uniprot.org/uniprot/A0A5K1UDP4|||http://purl.uniprot.org/uniprot/U3E2C8 ^@ Similarity ^@ Belongs to the BACURD family. http://togogenome.org/gene/9483:APOBEC3G ^@ http://purl.uniprot.org/uniprot/C0KTR7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||Cytoplasm|||DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA.|||Homodimer.|||Nucleus|||P-body|||The CMP/dCMP deaminase domain 1 mediates RNA binding, RNA-dependent oligomerization and virion incorporation whereas the CMP/dCMP deaminase domain 2 confers deoxycytidine deaminase activity and substrate sequence specificity. http://togogenome.org/gene/9483:XRCC6 ^@ http://purl.uniprot.org/uniprot/U3FBT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ku70 family.|||Nucleus http://togogenome.org/gene/9483:E2F7 ^@ http://purl.uniprot.org/uniprot/A0A2R8M8J5|||http://purl.uniprot.org/uniprot/F7E4B0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9483:PRM2 ^@ http://purl.uniprot.org/uniprot/Q28337|||http://purl.uniprot.org/uniprot/U3B7U7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the protamine P2 family.|||Chromosome|||Interacts with TDRP.|||Nucleus|||Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.|||Proteolytic processing into mature chains is required for histone eviction during spermatogenesis. Transition proteins (TNP1 and TNP2) are required for processing.|||Testis. http://togogenome.org/gene/9483:TAGLN ^@ http://purl.uniprot.org/uniprot/F7I1Q9 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/9483:NGFR ^@ http://purl.uniprot.org/uniprot/F7C0A9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:RTN3 ^@ http://purl.uniprot.org/uniprot/F6WF07|||http://purl.uniprot.org/uniprot/U3EY57 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:GLE1 ^@ http://purl.uniprot.org/uniprot/F7AHA4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GLE1 family.|||Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/9483:IMPA2 ^@ http://purl.uniprot.org/uniprot/U3DAH9 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/9483:UGGT1 ^@ http://purl.uniprot.org/uniprot/U3DBX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 8 family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9483:PYGL ^@ http://purl.uniprot.org/uniprot/U3CPB0 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/9483:PGAM1 ^@ http://purl.uniprot.org/uniprot/F6Y5Q5 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/9483:YWHAZ ^@ http://purl.uniprot.org/uniprot/U3E3R3 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9483:NUP98 ^@ http://purl.uniprot.org/uniprot/F6Z5L4|||http://purl.uniprot.org/uniprot/U3EEI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin GLFG family.|||Nucleus membrane|||nuclear pore complex http://togogenome.org/gene/9483:PSMA2 ^@ http://purl.uniprot.org/uniprot/F7IE60 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9483:SH2D1A ^@ http://purl.uniprot.org/uniprot/A0A8I3X5W5 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. http://togogenome.org/gene/9483:MB ^@ http://purl.uniprot.org/uniprot/F6PMG4 ^@ Function|||Similarity ^@ Belongs to the globin family.|||Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. http://togogenome.org/gene/9483:SF3A1 ^@ http://purl.uniprot.org/uniprot/U3FGV5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:GNA15 ^@ http://purl.uniprot.org/uniprot/F7I539 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/9483:BOLA1 ^@ http://purl.uniprot.org/uniprot/F7CF23 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/9483:ITGAX ^@ http://purl.uniprot.org/uniprot/A6N6I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9483:OTUB2 ^@ http://purl.uniprot.org/uniprot/A0A2R8MS46 ^@ Similarity ^@ Belongs to the peptidase C65 family. http://togogenome.org/gene/9483:HOXD8 ^@ http://purl.uniprot.org/uniprot/U3E6J0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:TRPC1 ^@ http://purl.uniprot.org/uniprot/U3D194 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.|||Membrane|||Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. http://togogenome.org/gene/9483:MEIS2 ^@ http://purl.uniprot.org/uniprot/A0A2R8PDQ0|||http://purl.uniprot.org/uniprot/F7EAH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/9483:LOC100407742 ^@ http://purl.uniprot.org/uniprot/U3ELW0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat HIR1 family.|||Nucleus|||Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle. http://togogenome.org/gene/9483:ESCO1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y947 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:MICOS13 ^@ http://purl.uniprot.org/uniprot/U3C9P8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic13 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9483:DCC ^@ http://purl.uniprot.org/uniprot/F7H4V7|||http://purl.uniprot.org/uniprot/U3F0X3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. DCC family.|||Membrane http://togogenome.org/gene/9483:AP1S3 ^@ http://purl.uniprot.org/uniprot/A0A2R8M4W3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||Membrane|||clathrin-coated pit http://togogenome.org/gene/9483:FSHB ^@ http://purl.uniprot.org/uniprot/F7IQC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/9483:OOEP ^@ http://purl.uniprot.org/uniprot/B0KWA6 ^@ Similarity ^@ Belongs to the KHDC1 family. http://togogenome.org/gene/9483:SYBU ^@ http://purl.uniprot.org/uniprot/A0A5F4W3A6|||http://purl.uniprot.org/uniprot/F7H9H4|||http://purl.uniprot.org/uniprot/F7IMS6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:CACYBP ^@ http://purl.uniprot.org/uniprot/U3B8Y1 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).|||Nucleus http://togogenome.org/gene/9483:LOC103794241 ^@ http://purl.uniprot.org/uniprot/A0A5F4WF65 ^@ Function|||Similarity ^@ Belongs to the eIF-1A family.|||Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. http://togogenome.org/gene/9483:CREBL2 ^@ http://purl.uniprot.org/uniprot/A0A2R8PH20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. ATF subfamily.|||Nucleus http://togogenome.org/gene/9483:IL1RAP ^@ http://purl.uniprot.org/uniprot/F6QTT3|||http://purl.uniprot.org/uniprot/F7IE70|||http://purl.uniprot.org/uniprot/U3BCW8 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9483:RHCE ^@ http://purl.uniprot.org/uniprot/F7I3R6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/9483:PNKD ^@ http://purl.uniprot.org/uniprot/F6YQM1 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. http://togogenome.org/gene/9483:EEF1B2 ^@ http://purl.uniprot.org/uniprot/F7GY27 ^@ Function|||Similarity|||Subunit ^@ Belongs to the EF-1-beta/EF-1-delta family.|||EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.|||EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. http://togogenome.org/gene/9483:LOC100399107 ^@ http://purl.uniprot.org/uniprot/A0A8I3W5H7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9483:ARPC3 ^@ http://purl.uniprot.org/uniprot/F7IHC5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC3 family.|||Component of the Arp2/3 complex.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton http://togogenome.org/gene/9483:TMEM184B ^@ http://purl.uniprot.org/uniprot/U3BZH9|||http://purl.uniprot.org/uniprot/U3EME4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:LOC103794898 ^@ http://purl.uniprot.org/uniprot/F7FTX6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS1 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.|||Cytoplasm|||May play a role during erythropoiesis through regulation of transcription factor DDIT3.|||Nucleus|||nucleolus http://togogenome.org/gene/9483:CASQ1 ^@ http://purl.uniprot.org/uniprot/A0A8I3WPH2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calsequestrin family.|||Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.|||Sarcoplasmic reticulum lumen http://togogenome.org/gene/9483:KPNB1 ^@ http://purl.uniprot.org/uniprot/F7IN96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the importin beta family. Importin beta-1 subfamily.|||Cytoplasm http://togogenome.org/gene/9483:SLC11A1 ^@ http://purl.uniprot.org/uniprot/U3DZC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NRAMP family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/9483:GRK6 ^@ http://purl.uniprot.org/uniprot/F6QAF7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9483:EFS ^@ http://purl.uniprot.org/uniprot/U3DRH1 ^@ Similarity ^@ Belongs to the CAS family. http://togogenome.org/gene/9483:CA9 ^@ http://purl.uniprot.org/uniprot/F7I0J5 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9483:POT1 ^@ http://purl.uniprot.org/uniprot/F7FJ05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the telombin family.|||Nucleus|||telomere http://togogenome.org/gene/9483:TFAP2B ^@ http://purl.uniprot.org/uniprot/U3EVG1 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/9483:ADCYAP1 ^@ http://purl.uniprot.org/uniprot/U3CGG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/9483:SBNO1 ^@ http://purl.uniprot.org/uniprot/F6Y413|||http://purl.uniprot.org/uniprot/U3BXS3 ^@ Similarity ^@ Belongs to the SBNO family. http://togogenome.org/gene/9483:TSPAN31 ^@ http://purl.uniprot.org/uniprot/F7GXR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9483:H2AFV ^@ http://purl.uniprot.org/uniprot/A0A2R8P821|||http://purl.uniprot.org/uniprot/U3DUR7|||http://purl.uniprot.org/uniprot/U3EEU6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9483:MAF1 ^@ http://purl.uniprot.org/uniprot/U3DXM9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MAF1 family.|||Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.|||Nucleus http://togogenome.org/gene/9483:ATP5F1E ^@ http://purl.uniprot.org/uniprot/F7GPK5 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ATPase epsilon family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. http://togogenome.org/gene/9483:ATF7IP ^@ http://purl.uniprot.org/uniprot/F7ILH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCAF family.|||Nucleus http://togogenome.org/gene/9483:TM9SF1 ^@ http://purl.uniprot.org/uniprot/F6PMW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/9483:KHDRBS1 ^@ http://purl.uniprot.org/uniprot/U3DMI6 ^@ Similarity ^@ Belongs to the KHDRBS family. http://togogenome.org/gene/9483:ADAT2 ^@ http://purl.uniprot.org/uniprot/U3F1L5 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.|||Probably participates in deamination of adenosine-34 to inosine in many tRNAs. http://togogenome.org/gene/9483:ENKD1 ^@ http://purl.uniprot.org/uniprot/F7HVV8 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9483:COQ4 ^@ http://purl.uniprot.org/uniprot/F6WM74 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ4 family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:MAPK8 ^@ http://purl.uniprot.org/uniprot/A0A5K1UJA7|||http://purl.uniprot.org/uniprot/U3FKG6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/9483:ANXA7 ^@ http://purl.uniprot.org/uniprot/F7DW50|||http://purl.uniprot.org/uniprot/F7EAB2 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9483:PARPBP ^@ http://purl.uniprot.org/uniprot/F7INL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PARI family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:PGC ^@ http://purl.uniprot.org/uniprot/Q9N2D3 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Hydrolyzes a variety of proteins.|||Inhibited by pepstatin.|||Secreted http://togogenome.org/gene/9483:LOC103789626 ^@ http://purl.uniprot.org/uniprot/F7GPI1 ^@ Similarity ^@ Belongs to the NOP10 family. http://togogenome.org/gene/9483:DGCR2 ^@ http://purl.uniprot.org/uniprot/U3F7U6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:LITAF ^@ http://purl.uniprot.org/uniprot/U3BJG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/9483:NNMT ^@ http://purl.uniprot.org/uniprot/F6T2K2 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. http://togogenome.org/gene/9483:PSMB1 ^@ http://purl.uniprot.org/uniprot/U3DT66 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:TSNAX ^@ http://purl.uniprot.org/uniprot/F6TPC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the translin family.|||Nucleus http://togogenome.org/gene/9483:GPC6 ^@ http://purl.uniprot.org/uniprot/F7HKQ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/9483:PRSS36 ^@ http://purl.uniprot.org/uniprot/F7I9U8 ^@ Function|||Subcellular Location Annotation ^@ Serine protease. Has a preference for substrates with an Arg instead of a Lys residue in position P1.|||extracellular matrix http://togogenome.org/gene/9483:DGAT2L6 ^@ http://purl.uniprot.org/uniprot/F7IHM8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:SDC1 ^@ http://purl.uniprot.org/uniprot/F7I933 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane http://togogenome.org/gene/9483:RDH13 ^@ http://purl.uniprot.org/uniprot/A0A8I3VUZ7|||http://purl.uniprot.org/uniprot/U3D6L7 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9483:TLE1 ^@ http://purl.uniprot.org/uniprot/A0A2R8N1C0|||http://purl.uniprot.org/uniprot/U3D0L8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat Groucho/TLE family.|||Nucleus http://togogenome.org/gene/9483:HS3ST3A1 ^@ http://purl.uniprot.org/uniprot/F7IHW7 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9483:DNAJA2 ^@ http://purl.uniprot.org/uniprot/F7HVJ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:TOR1B ^@ http://purl.uniprot.org/uniprot/U3C1X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ClpA/ClpB family. Torsin subfamily.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9483:BTBD10 ^@ http://purl.uniprot.org/uniprot/A0A5F4WI75|||http://purl.uniprot.org/uniprot/A0A8I3VXR4|||http://purl.uniprot.org/uniprot/F6VL30|||http://purl.uniprot.org/uniprot/F7G7T7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:SCOC ^@ http://purl.uniprot.org/uniprot/F7GB77 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SCOC family.|||Positive regulator of amino acid starvation-induced autophagy.|||trans-Golgi network http://togogenome.org/gene/9483:ANP32B ^@ http://purl.uniprot.org/uniprot/F7ETK3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANP32 family.|||Multifunctional protein that is involved in the regulation of many processes.|||Nucleus http://togogenome.org/gene/9483:TAF6L ^@ http://purl.uniprot.org/uniprot/F7IFE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF6 family.|||Nucleus http://togogenome.org/gene/9483:ABI2 ^@ http://purl.uniprot.org/uniprot/F7EFN7|||http://purl.uniprot.org/uniprot/U3E8A1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABI family.|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/9483:CLTA ^@ http://purl.uniprot.org/uniprot/F7CXQ1|||http://purl.uniprot.org/uniprot/F7DG30|||http://purl.uniprot.org/uniprot/F7E533|||http://purl.uniprot.org/uniprot/U3EBK3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin light chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||coated pit http://togogenome.org/gene/9483:DNAJC22 ^@ http://purl.uniprot.org/uniprot/F7ISX1 ^@ Function|||Subcellular Location Annotation ^@ May function as a co-chaperone.|||Membrane http://togogenome.org/gene/9483:GK ^@ http://purl.uniprot.org/uniprot/A0A5K1VG34|||http://purl.uniprot.org/uniprot/F7A4R7|||http://purl.uniprot.org/uniprot/U3D3V9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FGGY kinase family.|||Cytoplasm http://togogenome.org/gene/9483:CDC123 ^@ http://purl.uniprot.org/uniprot/U3E0T7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC123 family.|||Cytoplasm|||Required for S phase entry of the cell cycle. http://togogenome.org/gene/9483:NAAA ^@ http://purl.uniprot.org/uniprot/A0A8I3W3F5|||http://purl.uniprot.org/uniprot/A0A8I3WJW4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acid ceramidase family.|||Heterodimer.|||Lysosome http://togogenome.org/gene/9483:LOC100408964 ^@ http://purl.uniprot.org/uniprot/A0A8I3XA00 ^@ Similarity ^@ Belongs to the Speedy/Ringo family. http://togogenome.org/gene/9483:PHAF1 ^@ http://purl.uniprot.org/uniprot/F6UKG3 ^@ Similarity ^@ Belongs to the PHAF1 family. http://togogenome.org/gene/9483:CUTA ^@ http://purl.uniprot.org/uniprot/F7INQ1|||http://purl.uniprot.org/uniprot/U3D5W8 ^@ Similarity|||Subunit ^@ Belongs to the CutA family.|||Homotrimer. http://togogenome.org/gene/9483:TICAM1 ^@ http://purl.uniprot.org/uniprot/U3F0S9 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Homodimer. Found in a multi-helicase-TICAM1 complex at least composed of DHX36, DDX1, DDX21 and TICAM1.|||Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines.|||Mitochondrion|||The N-terminal region is essential for activation of the IFNB promoter activity.|||autophagosome|||cytosol http://togogenome.org/gene/9483:CD82 ^@ http://purl.uniprot.org/uniprot/U3CCW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9483:GRM5 ^@ http://purl.uniprot.org/uniprot/U3F1K3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:ALDH1A2 ^@ http://purl.uniprot.org/uniprot/U3DC38 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9483:IMPDH1 ^@ http://purl.uniprot.org/uniprot/F7EBY6|||http://purl.uniprot.org/uniprot/F7EC54|||http://purl.uniprot.org/uniprot/U3FWE8 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.|||Nucleus http://togogenome.org/gene/9483:RPP30 ^@ http://purl.uniprot.org/uniprot/U3FPZ8 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal RNase P protein component 3 family. http://togogenome.org/gene/9483:MEIS1 ^@ http://purl.uniprot.org/uniprot/F7HDM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/9483:UBE2M ^@ http://purl.uniprot.org/uniprot/F7CFP7 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9483:DCBLD2 ^@ http://purl.uniprot.org/uniprot/A0A5K1VHP5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:RAPGEF2 ^@ http://purl.uniprot.org/uniprot/A0A2R8PKE4|||http://purl.uniprot.org/uniprot/U3DM90 ^@ Similarity ^@ Belongs to the RAPGEF2 family. http://togogenome.org/gene/9483:LOC100401402 ^@ http://purl.uniprot.org/uniprot/U3FH16 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Cell projection|||Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Perikaryon|||Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm. http://togogenome.org/gene/9483:GATAD2A ^@ http://purl.uniprot.org/uniprot/A0A2R8MVD8|||http://purl.uniprot.org/uniprot/U3DIW8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:HACL1 ^@ http://purl.uniprot.org/uniprot/U3BZ78 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/9483:ESS2 ^@ http://purl.uniprot.org/uniprot/U3CKQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESS2 family.|||Nucleus http://togogenome.org/gene/9483:MRPS18C ^@ http://purl.uniprot.org/uniprot/A0A8J8Y463 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Mitochondrion http://togogenome.org/gene/9483:ACTR1A ^@ http://purl.uniprot.org/uniprot/U3CBW6 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9483:LYRM7 ^@ http://purl.uniprot.org/uniprot/F7IQS0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.|||Belongs to the complex I LYR family.|||Interacts with UQCRFS1.|||Mitochondrion matrix http://togogenome.org/gene/9483:PHTF2 ^@ http://purl.uniprot.org/uniprot/F7I8N8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:HPSE2 ^@ http://purl.uniprot.org/uniprot/U3BP05 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 79 family. http://togogenome.org/gene/9483:DPYSL5 ^@ http://purl.uniprot.org/uniprot/F7I2B9 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/9483:LOC103792196 ^@ http://purl.uniprot.org/uniprot/A0A2R8MUI6 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9483:CLDN19 ^@ http://purl.uniprot.org/uniprot/A0A2R8N099 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9483:BRINP3 ^@ http://purl.uniprot.org/uniprot/F7I8S2 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/9483:CELF1 ^@ http://purl.uniprot.org/uniprot/F6SMS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CELF/BRUNOL family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:PAQR3 ^@ http://purl.uniprot.org/uniprot/F7GGE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9483:OR5I1 ^@ http://purl.uniprot.org/uniprot/F7H5R8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:CENPN ^@ http://purl.uniprot.org/uniprot/F6Z6E6 ^@ Similarity ^@ Belongs to the CENP-N/CHL4 family. http://togogenome.org/gene/9483:ETFA ^@ http://purl.uniprot.org/uniprot/F7EF24 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ETF alpha-subunit/FixB family.|||Binds 1 FAD per dimer.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion matrix|||The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). http://togogenome.org/gene/9483:GSDME ^@ http://purl.uniprot.org/uniprot/F7IGG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gasdermin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:STAT1 ^@ http://purl.uniprot.org/uniprot/A0A2R8P3H6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:IMMP1L ^@ http://purl.uniprot.org/uniprot/F7I6I9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26 family.|||Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.|||Heterodimer of 2 subunits, IMMPL1 and IMMPL2.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:TGFB1I1 ^@ http://purl.uniprot.org/uniprot/A0A8I3WX24|||http://purl.uniprot.org/uniprot/F6WK60 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the paxillin family.|||Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways.|||Nucleus matrix|||The LD (leucine and aspartate-rich) motif 3 mediates interaction with GIT1 and functions as a nuclear export signal.|||cytoskeleton|||focal adhesion http://togogenome.org/gene/9483:OGDHL ^@ http://purl.uniprot.org/uniprot/A0A5K1VL13 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/9483:CDADC1 ^@ http://purl.uniprot.org/uniprot/U3E343 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/9483:PIAS4 ^@ http://purl.uniprot.org/uniprot/F7HES4 ^@ Similarity ^@ Belongs to the PIAS family. http://togogenome.org/gene/9483:NCOA1 ^@ http://purl.uniprot.org/uniprot/U3FP54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRC/p160 nuclear receptor coactivator family.|||Nucleus http://togogenome.org/gene/9483:ERRFI1 ^@ http://purl.uniprot.org/uniprot/F7H303 ^@ Subcellular Location Annotation ^@ Membrane|||Nucleus http://togogenome.org/gene/9483:BARHL1 ^@ http://purl.uniprot.org/uniprot/F6U1C3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:FGF18 ^@ http://purl.uniprot.org/uniprot/A0A5F4WKI8 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9483:LOC100396019 ^@ http://purl.uniprot.org/uniprot/A0A8I3X6D9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9483:LOC103789858 ^@ http://purl.uniprot.org/uniprot/A0A5F4WFE7 ^@ Similarity ^@ Belongs to the STEEP1 family. http://togogenome.org/gene/9483:XPOT ^@ http://purl.uniprot.org/uniprot/U3EBE3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus|||tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. http://togogenome.org/gene/9483:ANTXR2 ^@ http://purl.uniprot.org/uniprot/U3CH90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATR family.|||Membrane http://togogenome.org/gene/9483:ATE1 ^@ http://purl.uniprot.org/uniprot/F7IL39|||http://purl.uniprot.org/uniprot/F7INE2|||http://purl.uniprot.org/uniprot/U3BHG0|||http://purl.uniprot.org/uniprot/U3C0E3 ^@ Function|||Similarity ^@ Belongs to the R-transferase family.|||Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. http://togogenome.org/gene/9483:CYP26A1 ^@ http://purl.uniprot.org/uniprot/F7A7M2 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9483:HAPLN1 ^@ http://purl.uniprot.org/uniprot/F7GR30 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:TELO2 ^@ http://purl.uniprot.org/uniprot/F6RHQ8 ^@ Similarity ^@ Belongs to the TEL2 family. http://togogenome.org/gene/9483:PES1 ^@ http://purl.uniprot.org/uniprot/U3AUB5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pescadillo family.|||Chromosome|||Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome. Interacts with IRS1 and UBTF. May interact with MAP1B.|||Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.|||Sumoylated.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9483:POP7 ^@ http://purl.uniprot.org/uniprot/F7DTG5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone-like Alba family.|||Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA.|||Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.|||Cytoplasmic granule|||nucleolus http://togogenome.org/gene/9483:SH3BGRL2 ^@ http://purl.uniprot.org/uniprot/F7DLV5|||http://purl.uniprot.org/uniprot/U3BEF5 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/9483:ALG6 ^@ http://purl.uniprot.org/uniprot/U3BC09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG6/ALG8 glucosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:AURKA ^@ http://purl.uniprot.org/uniprot/A0A8I3WN83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.|||centrosome http://togogenome.org/gene/9483:P3H1 ^@ http://purl.uniprot.org/uniprot/F7IRA2 ^@ Similarity ^@ Belongs to the leprecan family. http://togogenome.org/gene/9483:HNF4G ^@ http://purl.uniprot.org/uniprot/A0A8I3WG28|||http://purl.uniprot.org/uniprot/F6WNW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9483:MPPE1 ^@ http://purl.uniprot.org/uniprot/U3ERB6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metallophosphoesterase superfamily. MPPE1 family.|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Interacts with GPI-anchor proteins. Interacts with TMED10.|||Membrane|||Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.|||cis-Golgi network membrane http://togogenome.org/gene/9483:IL13RA1 ^@ http://purl.uniprot.org/uniprot/F7GLB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 5 subfamily.|||Membrane http://togogenome.org/gene/9483:IQCG ^@ http://purl.uniprot.org/uniprot/F7CEK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC9 family.|||flagellum|||flagellum axoneme http://togogenome.org/gene/9483:LMNA ^@ http://purl.uniprot.org/uniprot/U3FTJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intermediate filament family.|||Nucleus lamina http://togogenome.org/gene/9483:METAP1 ^@ http://purl.uniprot.org/uniprot/U3CAY5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/9483:TATDN1 ^@ http://purl.uniprot.org/uniprot/U3CPY9 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. http://togogenome.org/gene/9483:PIGV ^@ http://purl.uniprot.org/uniprot/U3DAR7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGV family.|||Endoplasmic reticulum membrane|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.|||Membrane http://togogenome.org/gene/9483:DNAJC27 ^@ http://purl.uniprot.org/uniprot/F7ISW3 ^@ Function|||Subunit ^@ GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.|||Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms). http://togogenome.org/gene/9483:PAICS ^@ http://purl.uniprot.org/uniprot/F6U4J5 ^@ Similarity|||Subunit ^@ Homooctamer.|||In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.|||In the N-terminal section; belongs to the SAICAR synthetase family. http://togogenome.org/gene/9483:CACNB2 ^@ http://purl.uniprot.org/uniprot/U3CR85|||http://purl.uniprot.org/uniprot/U3CVV9|||http://purl.uniprot.org/uniprot/U3D197 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||sarcolemma http://togogenome.org/gene/9483:RMI1 ^@ http://purl.uniprot.org/uniprot/F6R6A0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RMI1 family.|||Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.|||Nucleus http://togogenome.org/gene/9483:PARVA ^@ http://purl.uniprot.org/uniprot/A0A2R8MVK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the parvin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:MPC2 ^@ http://purl.uniprot.org/uniprot/F7ICP2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9483:CCR1 ^@ http://purl.uniprot.org/uniprot/Q9MYJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9483:NAA40 ^@ http://purl.uniprot.org/uniprot/F6TZV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. NAA40 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:PM20D2 ^@ http://purl.uniprot.org/uniprot/F6XUF6 ^@ Function|||Similarity ^@ Belongs to the peptidase M20A family.|||Catalyzes the peptide bond hydrolysis in dipeptides having basic amino acids lysine, ornithine or arginine at C-terminus. http://togogenome.org/gene/9483:LOC103792211 ^@ http://purl.uniprot.org/uniprot/A0A8I3W029 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9483:SIX1 ^@ http://purl.uniprot.org/uniprot/U3E127 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:HMGN4 ^@ http://purl.uniprot.org/uniprot/F7G9N2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/9483:LPAR2 ^@ http://purl.uniprot.org/uniprot/U3DEU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:MARCKS ^@ http://purl.uniprot.org/uniprot/F7HYZ1 ^@ Similarity ^@ Belongs to the MARCKS family. http://togogenome.org/gene/9483:DBT ^@ http://purl.uniprot.org/uniprot/U3CGC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Mitochondrion matrix http://togogenome.org/gene/9483:POLR2C ^@ http://purl.uniprot.org/uniprot/F6ZTF7 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/9483:CETN1 ^@ http://purl.uniprot.org/uniprot/A0A8I3W2T6 ^@ Similarity ^@ Belongs to the centrin family. http://togogenome.org/gene/9483:ZP3 ^@ http://purl.uniprot.org/uniprot/F7I9N9 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZP domain family. ZPC subfamily.|||Cell membrane|||Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.|||Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.|||The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.|||Zona pellucida http://togogenome.org/gene/9483:TTYH2 ^@ http://purl.uniprot.org/uniprot/F7GUD6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tweety family.|||Cell membrane|||Membrane|||Probable chloride channel. http://togogenome.org/gene/9483:HOXB5 ^@ http://purl.uniprot.org/uniprot/F6ZUY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9483:CA14 ^@ http://purl.uniprot.org/uniprot/F7IC13 ^@ Similarity ^@ Belongs to the alpha-carbonic anhydrase family. http://togogenome.org/gene/9483:MAN2B1 ^@ http://purl.uniprot.org/uniprot/U3ESG9 ^@ Cofactor|||Similarity ^@ Belongs to the glycosyl hydrolase 38 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9483:KCNF1 ^@ http://purl.uniprot.org/uniprot/F7H006 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:PGF ^@ http://purl.uniprot.org/uniprot/F7ITA1|||http://purl.uniprot.org/uniprot/U3BDP8 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/9483:IL15 ^@ http://purl.uniprot.org/uniprot/A0A2R8P5W0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Secreted http://togogenome.org/gene/9483:DSCC1 ^@ http://purl.uniprot.org/uniprot/F6YTT6 ^@ Similarity ^@ Belongs to the DCC1 family. http://togogenome.org/gene/9483:DPP4 ^@ http://purl.uniprot.org/uniprot/F7IHU4 ^@ Subcellular Location Annotation ^@ Cell membrane|||invadopodium membrane|||lamellipodium membrane http://togogenome.org/gene/9483:PCSK9 ^@ http://purl.uniprot.org/uniprot/A8T688 ^@ Activity Regulation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S8 family.|||Cell surface|||Cleavage by furin and PCSK5 generates a truncated inactive protein that is unable to induce LDLR degradation.|||Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways (By similarity).|||Cytoplasm|||Endoplasmic reticulum|||Endosome|||Golgi apparatus|||Its proteolytic activity is autoinhibited by the non-covalent binding of the propeptide to the catalytic domain. Inhibited by EGTA (By similarity).|||Lysosome|||Monomer. Can self-associate to form dimers and higher multimers which may have increased LDLR degrading activity. The precursor protein but not the mature protein may form multimers. Interacts with APOB, VLDLR, LRP8/APOER2 and BACE1. The full-length immature form (pro-PCSK9) interacts with SCNN1A, SCNN1B and SCNN1G. The pro-PCSK9 form (via C-terminal domain) interacts with LDLR. Interacts (via the C-terminal domain) with ANXA2 (via repeat Annexin 1); the interaction inhibits the degradation of LDLR.|||Phosphorylation protects the propeptide against proteolysis.|||Secreted|||The C-terminal domain (CRD) is essential for the LDLR-binding and degrading activities.|||The catalytic domain is responsible for mediating its self-association.|||Undergoes autocatalytic cleavage in the endoplasmic reticulum to release the propeptide from the N-terminus and the cleavage of the propeptide is strictly required for its maturation and activation. The cleaved propeptide however remains associated with the catalytic domain through non-covalent interactions, preventing potential substrates from accessing its active site. As a result, it is secreted from cells as a propeptide-containing, enzymatically inactive protein (By similarity). http://togogenome.org/gene/9483:MIX23 ^@ http://purl.uniprot.org/uniprot/F7GIH3 ^@ Similarity ^@ Belongs to the MIX23 family. http://togogenome.org/gene/9483:CCNI ^@ http://purl.uniprot.org/uniprot/U3F3I8 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9483:TECRL ^@ http://purl.uniprot.org/uniprot/A0A5F4W8X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Membrane http://togogenome.org/gene/9483:FGF12 ^@ http://purl.uniprot.org/uniprot/A0A2R8NAI2|||http://purl.uniprot.org/uniprot/U3C9Y3 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9483:ABCD3 ^@ http://purl.uniprot.org/uniprot/A0A5F4W933|||http://purl.uniprot.org/uniprot/U3FKC8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.|||Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.|||Membrane|||Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and NHERF1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through NHERF1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation.|||Peroxisome membrane http://togogenome.org/gene/9483:DPYSL3 ^@ http://purl.uniprot.org/uniprot/U3B2M3 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/9483:SLC7A1 ^@ http://purl.uniprot.org/uniprot/U3D7B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:VPS72 ^@ http://purl.uniprot.org/uniprot/U3BS67 ^@ Function|||Similarity ^@ Belongs to the VPS72/YL1 family.|||Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. http://togogenome.org/gene/9483:IMPACT ^@ http://purl.uniprot.org/uniprot/U3DNP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IMPACT family.|||Cytoplasm http://togogenome.org/gene/9483:TMEM134 ^@ http://purl.uniprot.org/uniprot/F6YEZ0|||http://purl.uniprot.org/uniprot/F6YF44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM134/TMEM230 family.|||Membrane http://togogenome.org/gene/9483:ATP6V0A1 ^@ http://purl.uniprot.org/uniprot/U3CN61|||http://purl.uniprot.org/uniprot/U3FPA5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/9483:RPN1 ^@ http://purl.uniprot.org/uniprot/F7FXJ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST1 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/9483:PBX1 ^@ http://purl.uniprot.org/uniprot/F7IPP8|||http://purl.uniprot.org/uniprot/U3CS37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/PBX homeobox family.|||Nucleus http://togogenome.org/gene/9483:MOSPD3 ^@ http://purl.uniprot.org/uniprot/F6XID8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:MT4 ^@ http://purl.uniprot.org/uniprot/F7ISN0 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9483:GTF2E1 ^@ http://purl.uniprot.org/uniprot/U3EL39 ^@ Function|||Similarity ^@ Belongs to the TFIIE alpha subunit family.|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. http://togogenome.org/gene/9483:PRND ^@ http://purl.uniprot.org/uniprot/A0A2R8MKM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prion family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:TIMP3 ^@ http://purl.uniprot.org/uniprot/B0KWT4 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/9483:HPX ^@ http://purl.uniprot.org/uniprot/F7I2I8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the hemopexin family.|||Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.|||Secreted http://togogenome.org/gene/9483:ZDHHC4 ^@ http://purl.uniprot.org/uniprot/F6Z4M3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9483:GPHA2 ^@ http://purl.uniprot.org/uniprot/U3DGG9 ^@ Caution|||Similarity ^@ Belongs to the glycoprotein hormones subunit alpha family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:NKIRAS2 ^@ http://purl.uniprot.org/uniprot/F7GUH1 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. http://togogenome.org/gene/9483:PPP2R2B ^@ http://purl.uniprot.org/uniprot/A0A8J8XP81|||http://purl.uniprot.org/uniprot/U3E8G8|||http://purl.uniprot.org/uniprot/U3ETB8 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/9483:NFE2L3 ^@ http://purl.uniprot.org/uniprot/A0A8I3WK70|||http://purl.uniprot.org/uniprot/F7I4F2 ^@ Similarity ^@ Belongs to the bZIP family. CNC subfamily. http://togogenome.org/gene/9483:COQ10A ^@ http://purl.uniprot.org/uniprot/F7EC97|||http://purl.uniprot.org/uniprot/F7EQA5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the COQ10 family.|||Interacts with coenzyme Q.|||Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. http://togogenome.org/gene/9483:IPMK ^@ http://purl.uniprot.org/uniprot/F6SSU3 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9483:OTUB1 ^@ http://purl.uniprot.org/uniprot/F6QN11 ^@ Similarity ^@ Belongs to the peptidase C65 family. http://togogenome.org/gene/9483:ASB4 ^@ http://purl.uniprot.org/uniprot/F7GMS4 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9483:ANO10 ^@ http://purl.uniprot.org/uniprot/A0A5F4W8J9|||http://purl.uniprot.org/uniprot/A0A5F4WEL5|||http://purl.uniprot.org/uniprot/U3DKS8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:SLC5A8 ^@ http://purl.uniprot.org/uniprot/A0A5F4WFU2 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:TTC4 ^@ http://purl.uniprot.org/uniprot/U3DS20 ^@ Similarity ^@ Belongs to the TTC4 family. http://togogenome.org/gene/9483:PAPSS2 ^@ http://purl.uniprot.org/uniprot/F7F717|||http://purl.uniprot.org/uniprot/F7FL78 ^@ Similarity ^@ In the C-terminal section; belongs to the sulfate adenylyltransferase family.|||In the N-terminal section; belongs to the APS kinase family. http://togogenome.org/gene/9483:PPIE ^@ http://purl.uniprot.org/uniprot/U3FEP0 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.|||Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. http://togogenome.org/gene/9483:PPP1R12B ^@ http://purl.uniprot.org/uniprot/U3CCN1 ^@ Subcellular Location Annotation|||Subunit ^@ PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.|||stress fiber http://togogenome.org/gene/9483:NEK9 ^@ http://purl.uniprot.org/uniprot/F7I9E1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. http://togogenome.org/gene/9483:NXF1 ^@ http://purl.uniprot.org/uniprot/U3DVC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NXF family.|||Cytoplasm|||nucleoplasm http://togogenome.org/gene/9483:TCTA ^@ http://purl.uniprot.org/uniprot/A0A8I3X618 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TCTA family.|||May be required for cellular fusion during osteoclastogenesis.|||Membrane http://togogenome.org/gene/9483:CNTNAP5 ^@ http://purl.uniprot.org/uniprot/A0A8J8XTB1 ^@ Caution|||Similarity ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:VEGFD ^@ http://purl.uniprot.org/uniprot/F6VG74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDGF/VEGF growth factor family.|||Secreted http://togogenome.org/gene/9483:COQ9 ^@ http://purl.uniprot.org/uniprot/F6YBA9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COQ9 family.|||Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.|||Mitochondrion http://togogenome.org/gene/9483:SOAT1 ^@ http://purl.uniprot.org/uniprot/F7FD82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:WLS ^@ http://purl.uniprot.org/uniprot/U3FL96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the wntless family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:NEU1 ^@ http://purl.uniprot.org/uniprot/F6YMA5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/9483:IKBKE ^@ http://purl.uniprot.org/uniprot/F7IAT5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:ATG101 ^@ http://purl.uniprot.org/uniprot/F6SXY0 ^@ Similarity ^@ Belongs to the ATG101 family. http://togogenome.org/gene/9483:HS3ST3B1 ^@ http://purl.uniprot.org/uniprot/A0A2R8PMI3 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9483:ACSL5 ^@ http://purl.uniprot.org/uniprot/A0A8I4A221 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.|||Endoplasmic reticulum membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9483:INTS12 ^@ http://purl.uniprot.org/uniprot/F7HYK4 ^@ Similarity|||Subunit ^@ Belongs to the Integrator subunit 12 family.|||Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12. http://togogenome.org/gene/9483:ATP6V1D ^@ http://purl.uniprot.org/uniprot/U3D2W2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase D subunit family.|||cilium|||clathrin-coated vesicle membrane http://togogenome.org/gene/9483:GLYATL3 ^@ http://purl.uniprot.org/uniprot/A0A8I4A4R1 ^@ Similarity ^@ Belongs to the glycine N-acyltransferase family. http://togogenome.org/gene/9483:SLAIN2 ^@ http://purl.uniprot.org/uniprot/A0A2R8M343|||http://purl.uniprot.org/uniprot/U3BI85 ^@ Similarity ^@ Belongs to the SLAIN motif-containing family. http://togogenome.org/gene/9483:OSBPL11 ^@ http://purl.uniprot.org/uniprot/F6U8U2 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9483:SCRN3 ^@ http://purl.uniprot.org/uniprot/F7HV39 ^@ Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily. http://togogenome.org/gene/9483:SMC1A ^@ http://purl.uniprot.org/uniprot/F7IDJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC1 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/9483:MCOLN2 ^@ http://purl.uniprot.org/uniprot/F6TMD9 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9483:MAGOHB ^@ http://purl.uniprot.org/uniprot/F7I061 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mago nashi family.|||Nucleus http://togogenome.org/gene/9483:CSF2 ^@ http://purl.uniprot.org/uniprot/B0KWQ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GM-CSF family.|||Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.|||Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.|||Secreted http://togogenome.org/gene/9483:TMEM129 ^@ http://purl.uniprot.org/uniprot/F7GUY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM129 family.|||Membrane http://togogenome.org/gene/9483:NFKB1 ^@ http://purl.uniprot.org/uniprot/F6V7I0|||http://purl.uniprot.org/uniprot/U3FK78 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9483:FLVCR2 ^@ http://purl.uniprot.org/uniprot/F7HXI9|||http://purl.uniprot.org/uniprot/F7HXJ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:PLAUR ^@ http://purl.uniprot.org/uniprot/F6QVF1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9483:ADORA3 ^@ http://purl.uniprot.org/uniprot/U3DWN6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. http://togogenome.org/gene/9483:LOC100404734 ^@ http://purl.uniprot.org/uniprot/A0A8I3WI83 ^@ Similarity ^@ Belongs to the cystatin family. http://togogenome.org/gene/9483:LZIC ^@ http://purl.uniprot.org/uniprot/F7BV86 ^@ Similarity ^@ Belongs to the CTNNBIP1 family. http://togogenome.org/gene/9483:SUV39H2 ^@ http://purl.uniprot.org/uniprot/F7AGB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.|||Nucleus|||centromere http://togogenome.org/gene/9483:COQ8A ^@ http://purl.uniprot.org/uniprot/F7GNJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family.|||Membrane http://togogenome.org/gene/9483:DMRT3 ^@ http://purl.uniprot.org/uniprot/A0A5F4VV30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/9483:FAM167B ^@ http://purl.uniprot.org/uniprot/F6QAE5 ^@ Similarity ^@ Belongs to the FAM167 (SEC) family. http://togogenome.org/gene/9483:ESYT3 ^@ http://purl.uniprot.org/uniprot/U3B9Y0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the extended synaptotagmin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:CDC25A ^@ http://purl.uniprot.org/uniprot/F6UZN3|||http://purl.uniprot.org/uniprot/F6UZV6 ^@ Function|||Similarity ^@ Belongs to the MPI phosphatase family.|||Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. http://togogenome.org/gene/9483:SCARB2 ^@ http://purl.uniprot.org/uniprot/U3F7N9 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/9483:GSS ^@ http://purl.uniprot.org/uniprot/Q1HGK4 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic GSH synthase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/9483:PITX1 ^@ http://purl.uniprot.org/uniprot/F7HTS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9483:LOC108593219 ^@ http://purl.uniprot.org/uniprot/U3EIA4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus|||Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.|||cytosol http://togogenome.org/gene/9483:CSTF1 ^@ http://purl.uniprot.org/uniprot/F7GJ78 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:TRIM39 ^@ http://purl.uniprot.org/uniprot/U3CT43 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRIM/RBCC family.|||Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:XIAP ^@ http://purl.uniprot.org/uniprot/B0KWH9 ^@ Similarity ^@ Belongs to the IAP family. http://togogenome.org/gene/9483:SYS1 ^@ http://purl.uniprot.org/uniprot/U3ECS1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SYS1 family.|||Golgi apparatus membrane|||Interacts with ARFRP1.|||Involved in protein trafficking. May serve as a receptor for ARFRP1.|||Membrane http://togogenome.org/gene/9483:CALHM1 ^@ http://purl.uniprot.org/uniprot/F6QMY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9483:LOC100395465 ^@ http://purl.uniprot.org/uniprot/B0KWS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:NIPSNAP1 ^@ http://purl.uniprot.org/uniprot/F7IGZ2 ^@ Similarity ^@ Belongs to the NipSnap family. http://togogenome.org/gene/9483:MRPL1 ^@ http://purl.uniprot.org/uniprot/U3D3C9 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9483:PTPN1 ^@ http://purl.uniprot.org/uniprot/F6SC52 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. http://togogenome.org/gene/9483:CDKL1 ^@ http://purl.uniprot.org/uniprot/F7GM77 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:SLC25A43 ^@ http://purl.uniprot.org/uniprot/A0A8J8YHB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9483:VPS35 ^@ http://purl.uniprot.org/uniprot/F7H0E8 ^@ Function|||Similarity ^@ Belongs to the VPS35 family.|||Plays a role in vesicular protein sorting. http://togogenome.org/gene/9483:HPS3 ^@ http://purl.uniprot.org/uniprot/U3E815 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.|||Cytoplasm|||Involved in early stages of melanosome biogenesis and maturation. http://togogenome.org/gene/9483:ACER3 ^@ http://purl.uniprot.org/uniprot/F6XIB0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Membrane http://togogenome.org/gene/9483:ESR2 ^@ http://purl.uniprot.org/uniprot/Q95ME9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/9483:GH1P6 ^@ http://purl.uniprot.org/uniprot/Q8MI74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Secreted http://togogenome.org/gene/9483:ING2 ^@ http://purl.uniprot.org/uniprot/F6V9W3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9483:TMEM14C ^@ http://purl.uniprot.org/uniprot/U3BQG5 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/9483:LOC103794477 ^@ http://purl.uniprot.org/uniprot/F6VGW5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL28 family. http://togogenome.org/gene/9483:EDA ^@ http://purl.uniprot.org/uniprot/A0A0U5J5L9|||http://purl.uniprot.org/uniprot/A0A2R8N1B1 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9483:LOC100395855 ^@ http://purl.uniprot.org/uniprot/F7DWR0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9483:CCR2 ^@ http://purl.uniprot.org/uniprot/F7DT70 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9483:ATP2B4 ^@ http://purl.uniprot.org/uniprot/A0A8I3WUW2|||http://purl.uniprot.org/uniprot/U3CQA9|||http://purl.uniprot.org/uniprot/U3D6X1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:LOC100400179 ^@ http://purl.uniprot.org/uniprot/F7HC29 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9483:RPL14 ^@ http://purl.uniprot.org/uniprot/F6PLX7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL14 family. http://togogenome.org/gene/9483:OSBPL8 ^@ http://purl.uniprot.org/uniprot/F7ADF6 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9483:PSME2 ^@ http://purl.uniprot.org/uniprot/U3CVT8 ^@ Similarity ^@ Belongs to the PA28 family. http://togogenome.org/gene/9483:FPR3 ^@ http://purl.uniprot.org/uniprot/A0A2R8N2M6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:LOC108589472 ^@ http://purl.uniprot.org/uniprot/B0VXF6 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9483:CFDP1 ^@ http://purl.uniprot.org/uniprot/F7IQY8 ^@ Function|||Subcellular Location Annotation ^@ May play a role during embryogenesis.|||kinetochore http://togogenome.org/gene/9483:AHCY ^@ http://purl.uniprot.org/uniprot/U3ED98 ^@ Cofactor|||Similarity ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit. http://togogenome.org/gene/9483:CCT8 ^@ http://purl.uniprot.org/uniprot/A0A8I3WX76|||http://purl.uniprot.org/uniprot/U3BFL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||cilium basal body http://togogenome.org/gene/9483:EIF3F ^@ http://purl.uniprot.org/uniprot/F6PQN1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit F family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm|||Phosphorylated. Phosphorylation is enhanced upon serum stimulation. http://togogenome.org/gene/9483:COX4I2 ^@ http://purl.uniprot.org/uniprot/F7IT30 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase IV family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9483:ERCC4 ^@ http://purl.uniprot.org/uniprot/F7HLG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPF family.|||Nucleus http://togogenome.org/gene/9483:LCORL ^@ http://purl.uniprot.org/uniprot/A0A8I3X4R7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:RNPS1 ^@ http://purl.uniprot.org/uniprot/F7CTQ3|||http://purl.uniprot.org/uniprot/F7CTS4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the splicing factor SR family.|||Found in mRNA splicing-dependent exon junction complexes (EJC). Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively; the ASAP and PSAP complexes probably are formed mutually exclusive. Component of the active spliceosome. Associates with polysomes. Interacts with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1 and TRA2B/SFRS10.|||Nucleus speckle http://togogenome.org/gene/9483:ANP32A ^@ http://purl.uniprot.org/uniprot/F7C9V4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANP32 family.|||Multifunctional protein that is involved in the regulation of many processes.|||Nucleus http://togogenome.org/gene/9483:TMEM97 ^@ http://purl.uniprot.org/uniprot/F7IFA2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TMEM97/sigma-2 receptor family.|||Endoplasmic reticulum membrane|||Interacts with NPC1.|||Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins.|||Membrane|||Nucleus membrane|||Rough endoplasmic reticulum membrane http://togogenome.org/gene/9483:SGK3 ^@ http://purl.uniprot.org/uniprot/F7I8H6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/9483:LOC100402677 ^@ http://purl.uniprot.org/uniprot/A0A2R8N908 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9483:LYNX1 ^@ http://purl.uniprot.org/uniprot/F7H437 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9483:EDN1 ^@ http://purl.uniprot.org/uniprot/F7H803 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Secreted http://togogenome.org/gene/9483:MYG1 ^@ http://purl.uniprot.org/uniprot/F6ZS88 ^@ Similarity ^@ Belongs to the MYG1 family. http://togogenome.org/gene/9483:RBM48 ^@ http://purl.uniprot.org/uniprot/U3DXH7 ^@ Function|||Similarity|||Subunit ^@ As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.|||Belongs to the RBM48 family.|||Component of the minor spliceosome. Within this complex, interacts with ARMC7 and PRPF8/PRP8. http://togogenome.org/gene/9483:TUBB6 ^@ http://purl.uniprot.org/uniprot/F7BBZ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9483:RAD52 ^@ http://purl.uniprot.org/uniprot/U3D250 ^@ Similarity ^@ Belongs to the RAD52 family. http://togogenome.org/gene/9483:LDHD ^@ http://purl.uniprot.org/uniprot/F7HV82 ^@ Similarity ^@ Belongs to the FAD-binding oxidoreductase/transferase type 4 family. http://togogenome.org/gene/9483:CYP26C1 ^@ http://purl.uniprot.org/uniprot/F7C6P2 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9483:ASB5 ^@ http://purl.uniprot.org/uniprot/A0A8I3X0U2|||http://purl.uniprot.org/uniprot/U3DCC2 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9483:GABRR3 ^@ http://purl.uniprot.org/uniprot/F7H4P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9483:SEC11A ^@ http://purl.uniprot.org/uniprot/A0A8J8YEM9|||http://purl.uniprot.org/uniprot/U3F5P8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Component of the signal peptidase complex.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:CLPP ^@ http://purl.uniprot.org/uniprot/U3DUU6 ^@ Similarity ^@ Belongs to the peptidase S14 family. http://togogenome.org/gene/9483:TRAF5 ^@ http://purl.uniprot.org/uniprot/U3DJM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/9483:LOC100403703 ^@ http://purl.uniprot.org/uniprot/U3E603 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.|||cytosol http://togogenome.org/gene/9483:TMEM19 ^@ http://purl.uniprot.org/uniprot/A0A8I4A1H3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM19 family.|||Membrane http://togogenome.org/gene/9483:AMBP ^@ http://purl.uniprot.org/uniprot/F6R1P3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Endoplasmic reticulum|||In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.|||Kunitz-type serine protease inhibitor. Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation. Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases.|||Membrane|||Mitochondrion inner membrane|||Monomer. Also occurs as a complex with tryptase in mast cells.|||Nucleus membrane|||cytosol|||extracellular matrix http://togogenome.org/gene/9483:VPS11 ^@ http://purl.uniprot.org/uniprot/U3C3H2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS11 family.|||Cytoplasmic vesicle|||Early endosome|||Late endosome membrane|||Lysosome membrane|||Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.|||autophagosome|||clathrin-coated vesicle http://togogenome.org/gene/9483:RASSF5 ^@ http://purl.uniprot.org/uniprot/F7IMG6 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9483:TBXAS1 ^@ http://purl.uniprot.org/uniprot/U3DSB5 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9483:TNFRSF19 ^@ http://purl.uniprot.org/uniprot/F7I198 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:CAST ^@ http://purl.uniprot.org/uniprot/A0A5F4W7D5|||http://purl.uniprot.org/uniprot/F7GIP0|||http://purl.uniprot.org/uniprot/F7GLR8|||http://purl.uniprot.org/uniprot/F7GQ91|||http://purl.uniprot.org/uniprot/F7GQ96 ^@ Function|||Similarity ^@ Belongs to the protease inhibitor I27 (calpastatin) family.|||Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. http://togogenome.org/gene/9483:LOC100401098 ^@ http://purl.uniprot.org/uniprot/F7HBV1 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/9483:LAPTM5 ^@ http://purl.uniprot.org/uniprot/F7I1A8 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/9483:SESN1 ^@ http://purl.uniprot.org/uniprot/F7HTE0|||http://purl.uniprot.org/uniprot/U3BTQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/9483:NOL10 ^@ http://purl.uniprot.org/uniprot/U3DJD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat NOL10/ENP2 family.|||nucleolus http://togogenome.org/gene/9483:FGF1 ^@ http://purl.uniprot.org/uniprot/B0KW92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heparin-binding growth factors family.|||Cytoplasm|||Nucleus|||Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.|||Secreted|||cell cortex|||cytosol http://togogenome.org/gene/9483:YWHAH ^@ http://purl.uniprot.org/uniprot/B0KWS1 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9483:TPRG1L ^@ http://purl.uniprot.org/uniprot/U3DY61 ^@ Similarity ^@ Belongs to the TPRG1 family. http://togogenome.org/gene/9483:CALCRL ^@ http://purl.uniprot.org/uniprot/F6YRQ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.|||Membrane|||Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. http://togogenome.org/gene/9483:SMG5 ^@ http://purl.uniprot.org/uniprot/F7ID90 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Plays a role in nonsense-mediated mRNA decay. http://togogenome.org/gene/9483:CYP2E1 ^@ http://purl.uniprot.org/uniprot/Q6LEM3 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.|||Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane|||Interacts with chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria.|||Membrane|||Microsome membrane|||Mitochondrion inner membrane|||The omega-1 hydroxylase activity is stimulated by cytochrome b5. http://togogenome.org/gene/9483:KPNA6 ^@ http://purl.uniprot.org/uniprot/F7FPD9 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9483:FXYD6 ^@ http://purl.uniprot.org/uniprot/F7FL84 ^@ Similarity ^@ Belongs to the FXYD family. http://togogenome.org/gene/9483:RBM3 ^@ http://purl.uniprot.org/uniprot/U3EBH3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:SERPINB10 ^@ http://purl.uniprot.org/uniprot/B0CMB0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the serpin family. Ov-serpin subfamily.|||Cytoplasm|||Nucleus|||Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus (By similarity). http://togogenome.org/gene/9483:ARF1 ^@ http://purl.uniprot.org/uniprot/F6W8R7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/9483:MTAP ^@ http://purl.uniprot.org/uniprot/F7I6R4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.|||Cytoplasm|||Homotrimer.|||Nucleus http://togogenome.org/gene/9483:SSR3 ^@ http://purl.uniprot.org/uniprot/F7IFI5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-gamma family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/9483:STARD13 ^@ http://purl.uniprot.org/uniprot/A0A8I3WG93|||http://purl.uniprot.org/uniprot/F6ZB18|||http://purl.uniprot.org/uniprot/U3D8C2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:PRKRIP1 ^@ http://purl.uniprot.org/uniprot/F7I545 ^@ Similarity ^@ Belongs to the PRKRIP1 family. http://togogenome.org/gene/9483:CUZD1 ^@ http://purl.uniprot.org/uniprot/F6X244 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:BLOC1S6 ^@ http://purl.uniprot.org/uniprot/A0A2R8MPZ9 ^@ Function|||Similarity ^@ Belongs to the BLOC1S6 family.|||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process. http://togogenome.org/gene/9483:ZNF706 ^@ http://purl.uniprot.org/uniprot/F7HSE6 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9483:DNM1L ^@ http://purl.uniprot.org/uniprot/A0A2R8MVS5|||http://purl.uniprot.org/uniprot/F6SIE1|||http://purl.uniprot.org/uniprot/F6TQ78|||http://purl.uniprot.org/uniprot/F6U0L1|||http://purl.uniprot.org/uniprot/U3BXM6|||http://purl.uniprot.org/uniprot/U3FH93 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/9483:CTNNAL1 ^@ http://purl.uniprot.org/uniprot/F7I0U2 ^@ Similarity ^@ Belongs to the vinculin/alpha-catenin family. http://togogenome.org/gene/9483:USP15 ^@ http://purl.uniprot.org/uniprot/F7F8G3|||http://purl.uniprot.org/uniprot/F7FM26 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Cytoplasm|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Nucleus http://togogenome.org/gene/9483:UBXN1 ^@ http://purl.uniprot.org/uniprot/F7IK28 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:CDK5RAP2 ^@ http://purl.uniprot.org/uniprot/F6ZC98 ^@ Subcellular Location Annotation ^@ Golgi apparatus|||centrosome http://togogenome.org/gene/9483:SUPT6H ^@ http://purl.uniprot.org/uniprot/U3D391 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT6 family.|||Nucleus|||Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). http://togogenome.org/gene/9483:LIF ^@ http://purl.uniprot.org/uniprot/F7GQ12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LIF/OSM family.|||LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.|||Secreted http://togogenome.org/gene/9483:MTX1 ^@ http://purl.uniprot.org/uniprot/U3D2E9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metaxin family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9483:RELT ^@ http://purl.uniprot.org/uniprot/F7I7U0 ^@ Similarity ^@ Belongs to the RELT family. http://togogenome.org/gene/9483:TNFRSF11B ^@ http://purl.uniprot.org/uniprot/F7HTR5 ^@ Caution|||Function|||Subunit ^@ Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:CLDN18 ^@ http://purl.uniprot.org/uniprot/A0A2R8M8V8|||http://purl.uniprot.org/uniprot/F6WTG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9483:LOC100406056 ^@ http://purl.uniprot.org/uniprot/A0A5F4VVT1 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/9483:UBE3A ^@ http://purl.uniprot.org/uniprot/A0A2R8N2Q5|||http://purl.uniprot.org/uniprot/U3EB97 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.|||Nucleus http://togogenome.org/gene/9483:PSME4 ^@ http://purl.uniprot.org/uniprot/A0A8I3VY39|||http://purl.uniprot.org/uniprot/F7A030|||http://purl.uniprot.org/uniprot/U3BKW6 ^@ Similarity ^@ Belongs to the BLM10 family. http://togogenome.org/gene/9483:CATSPERE ^@ http://purl.uniprot.org/uniprot/F7HLX8 ^@ Similarity ^@ Belongs to the CATSPERD family. http://togogenome.org/gene/9483:SCARF1 ^@ http://purl.uniprot.org/uniprot/U3CRP6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:SLC39A4 ^@ http://purl.uniprot.org/uniprot/A0A2R8MGZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Membrane http://togogenome.org/gene/9483:RER1 ^@ http://purl.uniprot.org/uniprot/U3DIV9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RER1 family.|||Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.|||Membrane http://togogenome.org/gene/9483:USP20 ^@ http://purl.uniprot.org/uniprot/U3CPF2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family. USP20/USP33 subfamily.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||centrosome|||perinuclear region http://togogenome.org/gene/9483:ALDH8A1 ^@ http://purl.uniprot.org/uniprot/F7HZS8 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9483:COPS8 ^@ http://purl.uniprot.org/uniprot/F6TJS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN8 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:LOXL2 ^@ http://purl.uniprot.org/uniprot/U3D6J6 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/9483:AHCYL1 ^@ http://purl.uniprot.org/uniprot/U3DDT1 ^@ Cofactor|||Similarity ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit. http://togogenome.org/gene/9483:EMC4 ^@ http://purl.uniprot.org/uniprot/F7EN63|||http://purl.uniprot.org/uniprot/F7EN65 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC4 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:BTG2 ^@ http://purl.uniprot.org/uniprot/F7H971 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9483:SERPINB7 ^@ http://purl.uniprot.org/uniprot/B0CMA8 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9483:NKX6-1 ^@ http://purl.uniprot.org/uniprot/F7GWX6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:MADD ^@ http://purl.uniprot.org/uniprot/F7E459|||http://purl.uniprot.org/uniprot/F7GT09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MADD family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9483:PARK7 ^@ http://purl.uniprot.org/uniprot/F7H340 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C56 family.|||Membrane raft http://togogenome.org/gene/9483:TNFSF13B ^@ http://purl.uniprot.org/uniprot/F7FUZ6 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9483:LOC100413404 ^@ http://purl.uniprot.org/uniprot/A0A6G6XEG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9483:GNGT1 ^@ http://purl.uniprot.org/uniprot/F6WMN3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9483:CAPZA1 ^@ http://purl.uniprot.org/uniprot/A0A2R8MC54 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/9483:CYB5R1 ^@ http://purl.uniprot.org/uniprot/F7I687 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/9483:MON1A ^@ http://purl.uniprot.org/uniprot/F7HTY3 ^@ Function|||Similarity ^@ Belongs to the MON1/SAND family.|||Plays an important role in membrane trafficking through the secretory apparatus. http://togogenome.org/gene/9483:NHERF1 ^@ http://purl.uniprot.org/uniprot/F7FEW8 ^@ Function|||Subcellular Location Annotation ^@ Apical cell membrane|||Cell membrane|||Endomembrane system|||Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. http://togogenome.org/gene/9483:NEK7 ^@ http://purl.uniprot.org/uniprot/U3FJS7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:LOC100400246 ^@ http://purl.uniprot.org/uniprot/F7I8N6 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pentraxin family.|||Binds 2 calcium ions per subunit.|||Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9483:LOC100394153 ^@ http://purl.uniprot.org/uniprot/A0A8I4A5V8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/9483:TOP3B ^@ http://purl.uniprot.org/uniprot/F7ADD1 ^@ Function|||Similarity ^@ Belongs to the type IA topoisomerase family.|||Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. http://togogenome.org/gene/9483:LTA ^@ http://purl.uniprot.org/uniprot/A0A0U5JA93 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.|||Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. Interacts with TNFRSF14.|||Membrane|||Secreted http://togogenome.org/gene/9483:GPAT3 ^@ http://purl.uniprot.org/uniprot/U3D170 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9483:CRYL1 ^@ http://purl.uniprot.org/uniprot/F7HM70 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/9483:STMN3 ^@ http://purl.uniprot.org/uniprot/U3DU69 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/9483:HAL ^@ http://purl.uniprot.org/uniprot/F6YL38 ^@ Similarity ^@ Belongs to the PAL/histidase family. http://togogenome.org/gene/9483:IMPG1 ^@ http://purl.uniprot.org/uniprot/F6SRM0 ^@ Subcellular Location Annotation ^@ interphotoreceptor matrix http://togogenome.org/gene/9483:EIF3H ^@ http://purl.uniprot.org/uniprot/U3CCN9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit H family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm http://togogenome.org/gene/9483:ATG4D ^@ http://purl.uniprot.org/uniprot/F7D851 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/9483:RBKS ^@ http://purl.uniprot.org/uniprot/F7H3K8 ^@ Activity Regulation|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Belongs to the carbohydrate kinase pfkB family.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Nucleus|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/9483:USP49 ^@ http://purl.uniprot.org/uniprot/B0KWN4 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9483:SPG21 ^@ http://purl.uniprot.org/uniprot/U3DFP9 ^@ Function|||Subunit ^@ Interacts with CD4. Interacts with ALDH16A1.|||May play a role as a negative regulatory factor in CD4-dependent T-cell activation. http://togogenome.org/gene/9483:NPY1R ^@ http://purl.uniprot.org/uniprot/F7I5Y1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9483:ZFPM2 ^@ http://purl.uniprot.org/uniprot/A0A5F4VRF0|||http://purl.uniprot.org/uniprot/A0A8I3WFX5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:FUT2 ^@ http://purl.uniprot.org/uniprot/F7HA38 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 11 family.|||Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose residue of glycoconjugates through an alpha(1,2) linkage leading to H antigen synthesis that is an intermediate substrate in the synthesis of ABO blood group antigens. H antigen is essential for maturation of the glomerular layer of the main olfactory bulb, in cell migration and early cell-cell contacts during tumor associated angiogenesis (By similarity). Preferentially fucosylates soluble lactose and to a lesser extent fucosylates glycolipids gangliosides GA1 and GM1a.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9483:PIK3C3 ^@ http://purl.uniprot.org/uniprot/U3DFJ6 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9483:S100A1 ^@ http://purl.uniprot.org/uniprot/U3D200 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the S-100 family.|||Cytoplasm|||Mitochondrion http://togogenome.org/gene/9483:GPR39 ^@ http://purl.uniprot.org/uniprot/U3DHX8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9483:KCND2 ^@ http://purl.uniprot.org/uniprot/U3CD42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.|||Cell junction|||Cell membrane|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane|||dendrite|||dendritic spine http://togogenome.org/gene/9483:PIP4P2 ^@ http://purl.uniprot.org/uniprot/A0A5F4WMQ6 ^@ Function|||Subcellular Location Annotation ^@ Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane|||phagosome membrane http://togogenome.org/gene/9483:ARMCX3 ^@ http://purl.uniprot.org/uniprot/F7GD88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eutherian X-chromosome-specific Armcx family.|||Membrane http://togogenome.org/gene/9483:AGO2 ^@ http://purl.uniprot.org/uniprot/A0A8I3XET5 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argonaute family. Ago subfamily.|||Hydroxylated. 4-hydroxylation appears to enhance protein stability but is not required for miRNA-binding or endonuclease activity.|||Interacts with DICER1 through its Piwi domain and with TARBP2 during assembly of the RNA-induced silencing complex (RISC). Together, DICER1, AGO2 and TARBP2 constitute the trimeric RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC). Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Note however that the term RISC has also been used to describe the trimeric RLC/miRLC. The formation of RISC complexes containing siRNAs rather than miRNAs appears to occur independently of DICER1. Interacts with AGO1. Also interacts with DDB1, DDX5, DDX6, DDX20, DHX30, DHX36, DDX47, DHX9, ELAVL, FXR1, GEMIN4, HNRNPF, IGF2BP1, ILF3, IMP8, MATR3, PABPC1, PRMT5, P4HA1, P4HB, RBM4, SART3, TNRC6A, TNRC6B, UPF1 and YBX1. Interacts with the P-body components DCP1A and XRN1. Associates with polysomes and messenger ribonucleoproteins (mNRPs). Interacts with RBM4; the interaction is modulated under stress-induced conditions, occurs under both cell proliferation and differentiation conditions and in an RNA-and phosphorylation-independent manner. Interacts with LIMD1, WTIP and AJUBA. Interacts with TRIM71. Interacts with APOBEC3G in an RNA-dependent manner. Interacts with APOBEC3A, APOBEC3C, APOBEC3F and APOBEC3H. Interacts with DICER1, TARBP2, EIF6, MOV10 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC). Interacts with FMR1. Interacts with ZFP36.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||P-body|||Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions.|||The Piwi domain may perform RNA cleavage by a mechanism similar to that of RNase H. However, while RNase H utilizes a triad of Asp-Asp-Glu (DDE) for metal ion coordination, this protein appears to utilize a triad of Asp-Asp-His (DDH). http://togogenome.org/gene/9483:SENP6 ^@ http://purl.uniprot.org/uniprot/U3DNX7|||http://purl.uniprot.org/uniprot/U3F906 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/9483:PDP2 ^@ http://purl.uniprot.org/uniprot/F6WMA3 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9483:IL4R ^@ http://purl.uniprot.org/uniprot/Q0PIT7 ^@ Function|||Similarity ^@ Belongs to the type I cytokine receptor family. Type 4 subfamily.|||Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. http://togogenome.org/gene/9483:LOC100414193 ^@ http://purl.uniprot.org/uniprot/B0VXC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:LOC103796238 ^@ http://purl.uniprot.org/uniprot/A0A8I3WLV8 ^@ Function|||Similarity ^@ Belongs to the SAA family.|||Major acute phase reactant. Apolipoprotein of the HDL complex. http://togogenome.org/gene/9483:PDCD5 ^@ http://purl.uniprot.org/uniprot/F6YB48 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/9483:UFM1 ^@ http://purl.uniprot.org/uniprot/U3DH81 ^@ Function|||Similarity ^@ Belongs to the UFM1 family.|||Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. http://togogenome.org/gene/9483:IL2RG ^@ http://purl.uniprot.org/uniprot/A5HJL6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:MEOX1 ^@ http://purl.uniprot.org/uniprot/A0A8I3WWZ6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:CGA ^@ http://purl.uniprot.org/uniprot/A0A5K1VJ21|||http://purl.uniprot.org/uniprot/P51499 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit alpha family.|||Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.|||Heterodimer. The active hormones thyrotropin, lutropin, follitropin and choriogonadotropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin, FSHB for follitropin and choriogonadotropin subunit beta/CGB for choriogonadotropin.|||Secreted|||Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. http://togogenome.org/gene/9483:PIM2 ^@ http://purl.uniprot.org/uniprot/F7C4B8 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.|||Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. http://togogenome.org/gene/9483:NUDT18 ^@ http://purl.uniprot.org/uniprot/F6ZVD3 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/9483:RPRD1B ^@ http://purl.uniprot.org/uniprot/F7IJC6 ^@ Function|||Similarity|||Subunit ^@ Associates with the RNA polymerase II complex.|||Belongs to the UPF0400 (RTT103) family.|||Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. http://togogenome.org/gene/9483:HESX1 ^@ http://purl.uniprot.org/uniprot/F7E187 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ANF homeobox family.|||Nucleus http://togogenome.org/gene/9483:RRP7A ^@ http://purl.uniprot.org/uniprot/U3BYA6 ^@ Similarity ^@ Belongs to the RRP7 family. http://togogenome.org/gene/9483:FICD ^@ http://purl.uniprot.org/uniprot/U3D3E3 ^@ Similarity ^@ Belongs to the fic family. http://togogenome.org/gene/9483:ZAR1L ^@ http://purl.uniprot.org/uniprot/F7BC83 ^@ Similarity|||Subunit ^@ Belongs to the ZAR1 family.|||Interacts with YBX2. http://togogenome.org/gene/9483:TMPRSS2 ^@ http://purl.uniprot.org/uniprot/F7H6E7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:ACTL6A ^@ http://purl.uniprot.org/uniprot/U3C2I1 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9483:MMACHC ^@ http://purl.uniprot.org/uniprot/U3E275 ^@ Similarity ^@ Belongs to the MMACHC family. http://togogenome.org/gene/9483:LOC100393374 ^@ http://purl.uniprot.org/uniprot/F7BEV5 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/9483:GINS4 ^@ http://purl.uniprot.org/uniprot/U3DIB3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GINS4/SLD5 family.|||Chromosome|||Nucleus|||Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. http://togogenome.org/gene/9483:MRPS9 ^@ http://purl.uniprot.org/uniprot/U3DD41 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/9483:SMC2 ^@ http://purl.uniprot.org/uniprot/U3BGS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC2 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/9483:LOC100395175 ^@ http://purl.uniprot.org/uniprot/F7IDZ6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9483:CLIC4 ^@ http://purl.uniprot.org/uniprot/F7EXF2 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/9483:MEGF11 ^@ http://purl.uniprot.org/uniprot/F6VXR6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:APLP1 ^@ http://purl.uniprot.org/uniprot/A0A5K1UW72|||http://purl.uniprot.org/uniprot/F7DJJ0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APP family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:MRPS33 ^@ http://purl.uniprot.org/uniprot/F6QIR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS33 family.|||Mitochondrion http://togogenome.org/gene/9483:SLC43A3 ^@ http://purl.uniprot.org/uniprot/F7C5I5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:VDAC2 ^@ http://purl.uniprot.org/uniprot/U3BRF6 ^@ Similarity ^@ Belongs to the eukaryotic mitochondrial porin family. http://togogenome.org/gene/9483:ATP6V1B2 ^@ http://purl.uniprot.org/uniprot/A0A2R8MBE4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits. http://togogenome.org/gene/9483:PRPF4B ^@ http://purl.uniprot.org/uniprot/F7GNQ7 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.|||Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF. http://togogenome.org/gene/9483:MIF ^@ http://purl.uniprot.org/uniprot/H9KWP1 ^@ Similarity ^@ Belongs to the MIF family. http://togogenome.org/gene/9483:USP1 ^@ http://purl.uniprot.org/uniprot/F7HWE7 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9483:LOC100386370 ^@ http://purl.uniprot.org/uniprot/F7HAW6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:SMIM19 ^@ http://purl.uniprot.org/uniprot/F7FD34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM19 family.|||Membrane http://togogenome.org/gene/9483:GLIPR1 ^@ http://purl.uniprot.org/uniprot/U3CWN0 ^@ Similarity ^@ Belongs to the CRISP family. http://togogenome.org/gene/9483:ADGRG3 ^@ http://purl.uniprot.org/uniprot/F6QY45 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:SLC25A1 ^@ http://purl.uniprot.org/uniprot/U3EX65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9483:PPP4R3C ^@ http://purl.uniprot.org/uniprot/F7BFK1 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/9483:LOC100415550 ^@ http://purl.uniprot.org/uniprot/A0A8I3W2Z9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIIc family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9483:VIPR2 ^@ http://purl.uniprot.org/uniprot/F6XPH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:RRAGC ^@ http://purl.uniprot.org/uniprot/F6WBJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/9483:GNG11 ^@ http://purl.uniprot.org/uniprot/F6X977 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9483:USB1 ^@ http://purl.uniprot.org/uniprot/F6TF64 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 2H phosphoesterase superfamily. USB1 family.|||Nucleus|||Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. http://togogenome.org/gene/9483:CDK2AP1 ^@ http://purl.uniprot.org/uniprot/A0A8I3W4M4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDK2AP family.|||Nucleus http://togogenome.org/gene/9483:NDUFS3 ^@ http://purl.uniprot.org/uniprot/F6VZL4 ^@ Similarity ^@ Belongs to the complex I 30 kDa subunit family. http://togogenome.org/gene/9483:LOC100390706 ^@ http://purl.uniprot.org/uniprot/A0A8I3VWL0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9483:EFEMP1 ^@ http://purl.uniprot.org/uniprot/F7B2A3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:BOLA2B ^@ http://purl.uniprot.org/uniprot/F7D8D9 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/9483:MCPH1 ^@ http://purl.uniprot.org/uniprot/A0A8I3W9V5|||http://purl.uniprot.org/uniprot/A0A8I3WU68|||http://purl.uniprot.org/uniprot/U3EH78 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.|||Interacts with CDC27 and maybe other components of the APC/C complex. Interacts with histone variant H2AX under DNA damage conditions.|||centrosome http://togogenome.org/gene/9483:ARPC1A ^@ http://purl.uniprot.org/uniprot/U3FEQ0 ^@ Function|||Similarity ^@ Belongs to the WD repeat ARPC1 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. http://togogenome.org/gene/9483:ACTL9 ^@ http://purl.uniprot.org/uniprot/F7FGP2 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9483:LOC100412636 ^@ http://purl.uniprot.org/uniprot/A0A5F4WMT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:IRGQ ^@ http://purl.uniprot.org/uniprot/U3CLC6 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. http://togogenome.org/gene/9483:STRN3 ^@ http://purl.uniprot.org/uniprot/F7I8F1|||http://purl.uniprot.org/uniprot/U3FCL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat striatin family.|||Membrane http://togogenome.org/gene/9483:STRADA ^@ http://purl.uniprot.org/uniprot/A0A2R8PI98|||http://purl.uniprot.org/uniprot/F6TYM5|||http://purl.uniprot.org/uniprot/U3CSP5 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. http://togogenome.org/gene/9483:C2H5orf63 ^@ http://purl.uniprot.org/uniprot/F7E4F2 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/9483:TNFSF15 ^@ http://purl.uniprot.org/uniprot/A0A0U5J7D7 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9483:DERL2 ^@ http://purl.uniprot.org/uniprot/U3CUW8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:LOC100390305 ^@ http://purl.uniprot.org/uniprot/A0A2R8MA88 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9483:MTMR3 ^@ http://purl.uniprot.org/uniprot/U3FL62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/9483:PVALB ^@ http://purl.uniprot.org/uniprot/F6ZWB4 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/9483:CHST14 ^@ http://purl.uniprot.org/uniprot/F7FE82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:DOK5 ^@ http://purl.uniprot.org/uniprot/F7BN10 ^@ Similarity ^@ Belongs to the DOK family. Type B subfamily. http://togogenome.org/gene/9483:POLR2F ^@ http://purl.uniprot.org/uniprot/F7HWV2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.|||Nucleus http://togogenome.org/gene/9483:FER ^@ http://purl.uniprot.org/uniprot/A0A8I3WXR3|||http://purl.uniprot.org/uniprot/U3C8J6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.|||Cell membrane|||Membrane|||cytoskeleton http://togogenome.org/gene/9483:SLITRK3 ^@ http://purl.uniprot.org/uniprot/F7IJP7 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9483:CORO6 ^@ http://purl.uniprot.org/uniprot/F7CGH9|||http://purl.uniprot.org/uniprot/U3EM49 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/9483:NXPE3 ^@ http://purl.uniprot.org/uniprot/U3DW86 ^@ Similarity ^@ Belongs to the NXPE family. http://togogenome.org/gene/9483:C6H2orf88 ^@ http://purl.uniprot.org/uniprot/F7HZ56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small membrane AKAP family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:LOC100412476 ^@ http://purl.uniprot.org/uniprot/O77570 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/9483:STX16 ^@ http://purl.uniprot.org/uniprot/U3DL97|||http://purl.uniprot.org/uniprot/U3FTM0 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9483:GPR137B ^@ http://purl.uniprot.org/uniprot/F6TJ23 ^@ Subcellular Location Annotation ^@ Lysosome membrane|||Membrane http://togogenome.org/gene/9483:CCDC93 ^@ http://purl.uniprot.org/uniprot/B0CMA3 ^@ Similarity ^@ Belongs to the CCDC93 family. http://togogenome.org/gene/9483:TXNIP ^@ http://purl.uniprot.org/uniprot/F7GFR5 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9483:HSD17B10 ^@ http://purl.uniprot.org/uniprot/U3D1B8 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9483:MYO10 ^@ http://purl.uniprot.org/uniprot/A0A8I4A4S3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||cytoskeleton http://togogenome.org/gene/9483:TERF2IP ^@ http://purl.uniprot.org/uniprot/F7IEA0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.|||Belongs to the RAP1 family.|||Homodimer.|||Nucleus|||telomere http://togogenome.org/gene/9483:SLC10A3 ^@ http://purl.uniprot.org/uniprot/B0KWT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/9483:HCCS ^@ http://purl.uniprot.org/uniprot/F6XSM6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c-type heme lyase family.|||Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9483:RRAGB ^@ http://purl.uniprot.org/uniprot/F7BFD1|||http://purl.uniprot.org/uniprot/F7BGE5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/9483:LOC100401718 ^@ http://purl.uniprot.org/uniprot/F7AI40 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space|||Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. http://togogenome.org/gene/9483:SIX2 ^@ http://purl.uniprot.org/uniprot/F6Z031 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:PSMC1 ^@ http://purl.uniprot.org/uniprot/F7DZ95 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9483:TLR7 ^@ http://purl.uniprot.org/uniprot/F6S8L8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9483:PPP2R2C ^@ http://purl.uniprot.org/uniprot/A0A2R8MBU1|||http://purl.uniprot.org/uniprot/F7HRR7|||http://purl.uniprot.org/uniprot/U3EWR4 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/9483:ST6GALNAC5 ^@ http://purl.uniprot.org/uniprot/U3CCQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9483:SNCA ^@ http://purl.uniprot.org/uniprot/F7GY62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synuclein family.|||Membrane|||Nucleus|||Secreted|||Synapse|||axon http://togogenome.org/gene/9483:DHX9 ^@ http://purl.uniprot.org/uniprot/U3CWY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DEAH subfamily.|||Nucleus http://togogenome.org/gene/9483:LOC100395495 ^@ http://purl.uniprot.org/uniprot/F7DWQ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9483:TFEC ^@ http://purl.uniprot.org/uniprot/A0A2R8MDP8|||http://purl.uniprot.org/uniprot/A0A2R8MPG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/9483:LOC100398433 ^@ http://purl.uniprot.org/uniprot/F7IHC5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC3 family.|||Component of the Arp2/3 complex.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton http://togogenome.org/gene/9483:KCNK16 ^@ http://purl.uniprot.org/uniprot/F7HMK7|||http://purl.uniprot.org/uniprot/F7HTD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9483:ATG12 ^@ http://purl.uniprot.org/uniprot/U3ER96 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATG12 family.|||Forms a conjugate with ATG5.|||Ubiquitin-like protein involved in autophagic vesicle formation. http://togogenome.org/gene/9483:ASTL ^@ http://purl.uniprot.org/uniprot/F7IPR9 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:RHAG ^@ http://purl.uniprot.org/uniprot/F6TSA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/9483:RAB27B ^@ http://purl.uniprot.org/uniprot/U3D1S2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/9483:POP4 ^@ http://purl.uniprot.org/uniprot/A0A2R8MIN0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 1 family.|||Component of nuclear RNase P and RNase MRP.|||Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.|||nucleolus http://togogenome.org/gene/9483:PLAU ^@ http://purl.uniprot.org/uniprot/U3D503 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:ADAM19 ^@ http://purl.uniprot.org/uniprot/U3FXS6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:LOC108594116 ^@ http://purl.uniprot.org/uniprot/F7IHV9 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9483:RCAN1 ^@ http://purl.uniprot.org/uniprot/F7ICJ9|||http://purl.uniprot.org/uniprot/F7ICK3 ^@ Similarity ^@ Belongs to the RCAN family. http://togogenome.org/gene/9483:COMT ^@ http://purl.uniprot.org/uniprot/U3CQ46 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.|||Cell membrane http://togogenome.org/gene/9483:NMNAT2 ^@ http://purl.uniprot.org/uniprot/U3CKG7 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/9483:INPP1 ^@ http://purl.uniprot.org/uniprot/F7ISD4 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/9483:LCA5 ^@ http://purl.uniprot.org/uniprot/F7E2G3 ^@ Similarity ^@ Belongs to the LCA5 family. http://togogenome.org/gene/9483:IGF2BP3 ^@ http://purl.uniprot.org/uniprot/F7HZQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM IMP/VICKZ family.|||P-body|||Stress granule http://togogenome.org/gene/9483:DUSP16 ^@ http://purl.uniprot.org/uniprot/F7IJ42 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9483:C5H17orf62 ^@ http://purl.uniprot.org/uniprot/A0A2R8N184|||http://purl.uniprot.org/uniprot/F6SWT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYBC1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:FOXJ2 ^@ http://purl.uniprot.org/uniprot/U3FLZ1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:TDRD7 ^@ http://purl.uniprot.org/uniprot/F7HUL2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TDRD7 family.|||Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.|||Cytoplasm|||Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex containing CABLES1, CDK16 and CDK17. Interacts with CABLES1, CDK17 and PIWIL1. http://togogenome.org/gene/9483:GPNMB ^@ http://purl.uniprot.org/uniprot/F7I265 ^@ Similarity ^@ Belongs to the PMEL/NMB family. http://togogenome.org/gene/9483:LOC100413757 ^@ http://purl.uniprot.org/uniprot/F7DXF3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS19 family. http://togogenome.org/gene/9483:ATAD1 ^@ http://purl.uniprot.org/uniprot/U3FN99 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9483:LOC100395124 ^@ http://purl.uniprot.org/uniprot/F6R1Q9 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9483:TFR2 ^@ http://purl.uniprot.org/uniprot/F7H9B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:CD3D ^@ http://purl.uniprot.org/uniprot/F7FPX1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:PRKN ^@ http://purl.uniprot.org/uniprot/U3FQA1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RBR family. Parkin subfamily.|||Forms an E3 ubiquitin ligase complex.|||Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.|||Mitochondrion|||cytosol http://togogenome.org/gene/9483:HARS2 ^@ http://purl.uniprot.org/uniprot/F7I7A3 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9483:KCNJ6 ^@ http://purl.uniprot.org/uniprot/F7BNG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.|||Membrane http://togogenome.org/gene/9483:OSBPL7 ^@ http://purl.uniprot.org/uniprot/F7I772|||http://purl.uniprot.org/uniprot/U3BMZ8 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9483:TMEM59 ^@ http://purl.uniprot.org/uniprot/F7I1M9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM59 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:ITM2B ^@ http://purl.uniprot.org/uniprot/U3EHU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITM2 family.|||Membrane http://togogenome.org/gene/9483:MDH2 ^@ http://purl.uniprot.org/uniprot/F6RTH7 ^@ Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 1 family.|||Homodimer. http://togogenome.org/gene/9483:ZDHHC7 ^@ http://purl.uniprot.org/uniprot/A0A5F4VXT5 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9483:GLDN ^@ http://purl.uniprot.org/uniprot/F7I4Y9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:TSSK2 ^@ http://purl.uniprot.org/uniprot/A0A2R8M342 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:NCEH1 ^@ http://purl.uniprot.org/uniprot/U3EYY4 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/9483:RPL18 ^@ http://purl.uniprot.org/uniprot/F6QKI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL18 family.|||Rough endoplasmic reticulum http://togogenome.org/gene/9483:RPL17 ^@ http://purl.uniprot.org/uniprot/F6Q3N9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/9483:PLSCR5 ^@ http://purl.uniprot.org/uniprot/F7IQL8 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/9483:FRK ^@ http://purl.uniprot.org/uniprot/F7HTW0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9483:PDE6H ^@ http://purl.uniprot.org/uniprot/A0A2R8N3S8 ^@ Function|||Similarity ^@ Belongs to the rod/cone cGMP-PDE gamma subunit family.|||Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. http://togogenome.org/gene/9483:BORCS5 ^@ http://purl.uniprot.org/uniprot/U3DRV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS5 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9483:MTHFR ^@ http://purl.uniprot.org/uniprot/U3CLG5 ^@ Similarity ^@ Belongs to the methylenetetrahydrofolate reductase family. http://togogenome.org/gene/9483:LMOD3 ^@ http://purl.uniprot.org/uniprot/F7GMF9 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9483:EIF2S1 ^@ http://purl.uniprot.org/uniprot/F7ANJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-2-alpha family.|||Stress granule http://togogenome.org/gene/9483:GLI1 ^@ http://purl.uniprot.org/uniprot/F7AEX2 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/9483:PTER ^@ http://purl.uniprot.org/uniprot/F7C4K6|||http://purl.uniprot.org/uniprot/F7CJ79 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.|||Binds 2 divalent metal cations per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:ATP6V1G2 ^@ http://purl.uniprot.org/uniprot/F7IEI0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9483:YTHDF2 ^@ http://purl.uniprot.org/uniprot/F6SGT3 ^@ Function|||Similarity ^@ Belongs to the YTHDF family.|||Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. http://togogenome.org/gene/9483:CCNT2 ^@ http://purl.uniprot.org/uniprot/F6PJF3|||http://purl.uniprot.org/uniprot/F6TT41 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9483:PRKAR2A ^@ http://purl.uniprot.org/uniprot/F7IC18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:CDKN1A ^@ http://purl.uniprot.org/uniprot/U3E394 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/9483:PAX9 ^@ http://purl.uniprot.org/uniprot/A0A8P2DCF2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with KDM5B.|||Nucleus|||Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs. http://togogenome.org/gene/9483:RPA3 ^@ http://purl.uniprot.org/uniprot/F6ZI81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the replication factor A protein 3 family.|||Nucleus http://togogenome.org/gene/9483:TOMM40 ^@ http://purl.uniprot.org/uniprot/U3BA11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom40 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9483:CAP2 ^@ http://purl.uniprot.org/uniprot/F6ULQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAP family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:TOR2A ^@ http://purl.uniprot.org/uniprot/A0A2R8MYK2|||http://purl.uniprot.org/uniprot/U3BYS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ClpA/ClpB family. Torsin subfamily.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9483:CHRM5 ^@ http://purl.uniprot.org/uniprot/F7FDZ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. http://togogenome.org/gene/9483:PIR ^@ http://purl.uniprot.org/uniprot/A0A8I4A1C7|||http://purl.uniprot.org/uniprot/F6TNI5 ^@ Similarity ^@ Belongs to the pirin family. http://togogenome.org/gene/9483:LUC7L ^@ http://purl.uniprot.org/uniprot/B0VX80 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/9483:STARD5 ^@ http://purl.uniprot.org/uniprot/U3BTT1 ^@ Function ^@ May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols. http://togogenome.org/gene/9483:PRKAR2B ^@ http://purl.uniprot.org/uniprot/F7ADV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:SMARCD3 ^@ http://purl.uniprot.org/uniprot/U3CD19|||http://purl.uniprot.org/uniprot/U3EBF1 ^@ Similarity ^@ Belongs to the SMARCD family. http://togogenome.org/gene/9483:CENPK ^@ http://purl.uniprot.org/uniprot/A0A8I3W2N6|||http://purl.uniprot.org/uniprot/A0A8J8XEV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-K/MCM22 family.|||Nucleus|||centromere http://togogenome.org/gene/9483:PGK1 ^@ http://purl.uniprot.org/uniprot/F7GSF5 ^@ Similarity|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Monomer. http://togogenome.org/gene/9483:RBPJ ^@ http://purl.uniprot.org/uniprot/A0A2R8MI49|||http://purl.uniprot.org/uniprot/U3CH38|||http://purl.uniprot.org/uniprot/U3E6R7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Su(H) family.|||Nucleus http://togogenome.org/gene/9483:NTS ^@ http://purl.uniprot.org/uniprot/F6T798 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurotensin family.|||Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.|||Secreted|||Vesicle|||secretory vesicle http://togogenome.org/gene/9483:PMPCB ^@ http://purl.uniprot.org/uniprot/F7FDX7 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/9483:ELOVL6 ^@ http://purl.uniprot.org/uniprot/A0A2R8MBN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:MYH8 ^@ http://purl.uniprot.org/uniprot/F7HJA3 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9483:KDELR2 ^@ http://purl.uniprot.org/uniprot/A0A5F4W9W6|||http://purl.uniprot.org/uniprot/F7BPN6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:CLTRN ^@ http://purl.uniprot.org/uniprot/F7C8H8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9483:RPL23A ^@ http://purl.uniprot.org/uniprot/F7EJ37 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/9483:NDUFC2 ^@ http://purl.uniprot.org/uniprot/F7FET4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFC2 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:FRZB ^@ http://purl.uniprot.org/uniprot/A0A5F4WMX9 ^@ Caution|||Function|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. http://togogenome.org/gene/9483:LOC108587827 ^@ http://purl.uniprot.org/uniprot/A0A8I3W8R6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIIc family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9483:PATL1 ^@ http://purl.uniprot.org/uniprot/F7IC02 ^@ Similarity ^@ Belongs to the PAT1 family. http://togogenome.org/gene/9483:LSM4 ^@ http://purl.uniprot.org/uniprot/F7HQY9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/9483:VPS37D ^@ http://purl.uniprot.org/uniprot/F6XCL3|||http://purl.uniprot.org/uniprot/U3DXY1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/9483:LOC100402586 ^@ http://purl.uniprot.org/uniprot/A0A5F4WJB8 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9483:DDC ^@ http://purl.uniprot.org/uniprot/A0A2R8MA76 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9483:PPP1R10 ^@ http://purl.uniprot.org/uniprot/F7C1C2 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers. http://togogenome.org/gene/9483:LOC100406067 ^@ http://purl.uniprot.org/uniprot/F7FGM2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9483:CREB5 ^@ http://purl.uniprot.org/uniprot/F7HFJ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bZIP family.|||Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1.|||Binds to the cAMP response element and activates transcription.|||Nucleus http://togogenome.org/gene/9483:RBCK1 ^@ http://purl.uniprot.org/uniprot/U3DDR1 ^@ Similarity ^@ Belongs to the RBR family. http://togogenome.org/gene/9483:OCLN ^@ http://purl.uniprot.org/uniprot/U3EJL6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Cell membrane|||May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.|||Membrane|||tight junction http://togogenome.org/gene/9483:TSC22D3 ^@ http://purl.uniprot.org/uniprot/F6R6E0|||http://purl.uniprot.org/uniprot/F7H3M4|||http://purl.uniprot.org/uniprot/F7I9B7 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/9483:OLFML3 ^@ http://purl.uniprot.org/uniprot/F7I8J0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:YAE1 ^@ http://purl.uniprot.org/uniprot/F7IGN5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9483:EPHA6 ^@ http://purl.uniprot.org/uniprot/F7GTW3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:NOVA2 ^@ http://purl.uniprot.org/uniprot/U3DQR7 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with PTBP2; the interaction is direct.|||Nucleus http://togogenome.org/gene/9483:AURKAIP1 ^@ http://purl.uniprot.org/uniprot/F7GKP5 ^@ Similarity ^@ Belongs to the mitochondrion-specific ribosomal protein mS38 family. http://togogenome.org/gene/9483:EMSY ^@ http://purl.uniprot.org/uniprot/F6QX26|||http://purl.uniprot.org/uniprot/F7APR2|||http://purl.uniprot.org/uniprot/F7AQS1|||http://purl.uniprot.org/uniprot/F7H8N3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:TMEM234 ^@ http://purl.uniprot.org/uniprot/U3EK19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM234 family.|||Membrane http://togogenome.org/gene/9483:TCP11L1 ^@ http://purl.uniprot.org/uniprot/F6ZT02 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/9483:EIF1AX ^@ http://purl.uniprot.org/uniprot/U3BE20 ^@ Function|||Similarity ^@ Belongs to the eIF-1A family.|||Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. http://togogenome.org/gene/9483:CAV1 ^@ http://purl.uniprot.org/uniprot/Q2QLG6|||http://purl.uniprot.org/uniprot/U3DG28 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||Homooligomer. Interacts (via the N-terminus) with DPP4; the interaction is direct. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Interacts with PACSIN2; this interaction induces membrane tubulation (By similarity). Interacts with BMX, BTK, CTNNB1, CDH1, GLIPR2, JUP, NOSTRIN, SNAP25 and STX1A. Interacts with SLC7A9. Interacts with TGFBR1. Interacts with CAVIN3 (via leucine-zipper domain) in a cholesterol-sensitive manner. Interacts with CAVIN1. Interacts with EHD2 in a cholesterol-dependent manner. Forms a ternary complex with UBXN6 and VCP; mediates CAV1 targeting to lysosomes for degradation. Interacts with ABCG1; this interaction regulates ABCG1-mediated cholesterol efflux (By similarity). Interacts with NEU3; this interaction enhances NEU3 sialidase activity within caveola. Interacts (via C-terminus) with SPRY1, SPRY2 (via C-terminus), SPRY3, and SPRY4 (By similarity).|||May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity).|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||Membrane raft|||Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.|||Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination. Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation. Ubiquitinated by ZNRF1; leading to degradation and modulation of the TLR4-mediated immune response.|||caveola http://togogenome.org/gene/9483:IFT43 ^@ http://purl.uniprot.org/uniprot/F7IQR4 ^@ Similarity ^@ Belongs to the IFT43 family. http://togogenome.org/gene/9483:PPP1R3B ^@ http://purl.uniprot.org/uniprot/F7FFM0 ^@ Subunit ^@ Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity. http://togogenome.org/gene/9483:MFNG ^@ http://purl.uniprot.org/uniprot/U3ECV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:TMEM106B ^@ http://purl.uniprot.org/uniprot/U3EI86 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/9483:WFIKKN2 ^@ http://purl.uniprot.org/uniprot/A0A5F4VT19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WFIKKN family.|||Secreted http://togogenome.org/gene/9483:SLC28A2 ^@ http://purl.uniprot.org/uniprot/A0A8I3ZZF4|||http://purl.uniprot.org/uniprot/F7GNR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Membrane http://togogenome.org/gene/9483:BMP6 ^@ http://purl.uniprot.org/uniprot/F7FSA8 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9483:ACTN2 ^@ http://purl.uniprot.org/uniprot/U3EFF9 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/9483:CD2 ^@ http://purl.uniprot.org/uniprot/A5HJL4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9483:ENPEP ^@ http://purl.uniprot.org/uniprot/F7EVP4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9483:CD164 ^@ http://purl.uniprot.org/uniprot/F7HWM0|||http://purl.uniprot.org/uniprot/U3BR40|||http://purl.uniprot.org/uniprot/U3F455 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD164 family.|||Membrane http://togogenome.org/gene/9483:AK3 ^@ http://purl.uniprot.org/uniprot/U3BDI8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK3 subfamily.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.|||Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.|||Mitochondrion matrix|||Monomer. http://togogenome.org/gene/9483:PHACTR2 ^@ http://purl.uniprot.org/uniprot/A0A2R8MAG7|||http://purl.uniprot.org/uniprot/A0A2R8PK56|||http://purl.uniprot.org/uniprot/F7HI08|||http://purl.uniprot.org/uniprot/U3DFP6|||http://purl.uniprot.org/uniprot/U3DHU4 ^@ Similarity|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin. http://togogenome.org/gene/9483:MINAR2 ^@ http://purl.uniprot.org/uniprot/F7GS61 ^@ Similarity ^@ Belongs to the MINAR family. http://togogenome.org/gene/9483:MAPK4 ^@ http://purl.uniprot.org/uniprot/U3ETP2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9483:TM4SF19 ^@ http://purl.uniprot.org/uniprot/F6UJ48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9483:ADPRM ^@ http://purl.uniprot.org/uniprot/A0A8I3WDL9 ^@ Similarity|||Subunit ^@ Belongs to the ADPRibase-Mn family.|||Monomer. http://togogenome.org/gene/9483:FHIP1B ^@ http://purl.uniprot.org/uniprot/U3C4A7|||http://purl.uniprot.org/uniprot/U3CPP9 ^@ Similarity ^@ Belongs to the FHIP family. http://togogenome.org/gene/9483:AKAP8 ^@ http://purl.uniprot.org/uniprot/F7DAJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AKAP95 family.|||Nucleus matrix http://togogenome.org/gene/9483:ARHGDIB ^@ http://purl.uniprot.org/uniprot/F7INT7 ^@ Similarity ^@ Belongs to the Rho GDI family. http://togogenome.org/gene/9483:PALS1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XEW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Cell membrane|||Endomembrane system|||adherens junction|||tight junction http://togogenome.org/gene/9483:ZNF202 ^@ http://purl.uniprot.org/uniprot/F7I290 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:RELL1 ^@ http://purl.uniprot.org/uniprot/F7FUT1 ^@ Similarity ^@ Belongs to the RELT family. http://togogenome.org/gene/9483:VAMP1 ^@ http://purl.uniprot.org/uniprot/F6YI66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9483:ATP6V0C ^@ http://purl.uniprot.org/uniprot/F7GH31 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.|||Vacuole membrane|||clathrin-coated vesicle membrane|||synaptic vesicle membrane http://togogenome.org/gene/9483:SGSM1 ^@ http://purl.uniprot.org/uniprot/F7HLL0|||http://purl.uniprot.org/uniprot/U3DVM6 ^@ Similarity ^@ Belongs to the RUTBC family. http://togogenome.org/gene/9483:IFNG ^@ http://purl.uniprot.org/uniprot/B9VS86 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II (or gamma) interferon family.|||Homodimer.|||Secreted|||Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL. Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation. http://togogenome.org/gene/9483:LANCL1 ^@ http://purl.uniprot.org/uniprot/F7EEA2 ^@ Similarity ^@ Belongs to the LanC-like protein family. http://togogenome.org/gene/9483:ACP1 ^@ http://purl.uniprot.org/uniprot/U3CJJ6|||http://purl.uniprot.org/uniprot/U3F3I4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.|||Belongs to the low molecular weight phosphotyrosine protein phosphatase family.|||Cytoplasm http://togogenome.org/gene/9483:JUNB ^@ http://purl.uniprot.org/uniprot/A0A8I4A422 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. Jun subfamily.|||Nucleus http://togogenome.org/gene/9483:DNAJC25 ^@ http://purl.uniprot.org/uniprot/F7ESD8 ^@ Similarity ^@ Belongs to the DNAJC25 family. http://togogenome.org/gene/9483:FSHR ^@ http://purl.uniprot.org/uniprot/C7C615 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.|||Membrane http://togogenome.org/gene/9483:HYAL3 ^@ http://purl.uniprot.org/uniprot/A0A2R8M733|||http://purl.uniprot.org/uniprot/F7I8M5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/9483:HOXA7 ^@ http://purl.uniprot.org/uniprot/B0VXK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9483:ATP2A2 ^@ http://purl.uniprot.org/uniprot/A0A5F4WMB1|||http://purl.uniprot.org/uniprot/A0A8I3VZY4|||http://purl.uniprot.org/uniprot/U3FYJ0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/9483:RIMKLA ^@ http://purl.uniprot.org/uniprot/F7I0K3 ^@ Similarity ^@ Belongs to the RimK family. http://togogenome.org/gene/9483:STAM2 ^@ http://purl.uniprot.org/uniprot/U3ET33 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the STAM family.|||Early endosome membrane|||Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. http://togogenome.org/gene/9483:TPP2 ^@ http://purl.uniprot.org/uniprot/A0A2R8MEJ0|||http://purl.uniprot.org/uniprot/F7BYW8 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9483:TBCCD1 ^@ http://purl.uniprot.org/uniprot/U3BAK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBCC family.|||centrosome|||spindle pole http://togogenome.org/gene/9483:MFAP2 ^@ http://purl.uniprot.org/uniprot/F7I4B1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MFAP family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9483:PHYHIPL ^@ http://purl.uniprot.org/uniprot/A0A2R8MLX1 ^@ Similarity ^@ Belongs to the PHYHIP family. http://togogenome.org/gene/9483:HSP90B1 ^@ http://purl.uniprot.org/uniprot/U3CJF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 90 family.|||Melanosome http://togogenome.org/gene/9483:B3GAT3 ^@ http://purl.uniprot.org/uniprot/F7IBB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:ASB1 ^@ http://purl.uniprot.org/uniprot/A0A2R8MZZ2 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9483:SLC16A13 ^@ http://purl.uniprot.org/uniprot/F7HT83 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:DAO ^@ http://purl.uniprot.org/uniprot/F7B5E9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAMOX/DASOX family.|||Peroxisome http://togogenome.org/gene/9483:SEPSECS ^@ http://purl.uniprot.org/uniprot/F7GM93 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SepSecS family.|||Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.|||Cytoplasm|||Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer. http://togogenome.org/gene/9483:RBBP7 ^@ http://purl.uniprot.org/uniprot/A0A2R8N0V5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:AGL ^@ http://purl.uniprot.org/uniprot/A0A8I3WN62|||http://purl.uniprot.org/uniprot/U3DB08 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycogen debranching enzyme family.|||Cytoplasm|||Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. http://togogenome.org/gene/9483:OSBPL9 ^@ http://purl.uniprot.org/uniprot/U3DSA3 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9483:USP10 ^@ http://purl.uniprot.org/uniprot/F6PHS2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family. USP10 subfamily.|||Cytoplasm|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9483:RTBDN ^@ http://purl.uniprot.org/uniprot/U3EWX7 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/9483:BANF1 ^@ http://purl.uniprot.org/uniprot/U3DBV0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:LTB4R ^@ http://purl.uniprot.org/uniprot/A0A5F4W1Z5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:SNRPD2 ^@ http://purl.uniprot.org/uniprot/U3E603 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.|||cytosol http://togogenome.org/gene/9483:VCL ^@ http://purl.uniprot.org/uniprot/A0A5K1UWX2|||http://purl.uniprot.org/uniprot/U3B7Z2|||http://purl.uniprot.org/uniprot/U3FGU8|||http://purl.uniprot.org/uniprot/U3FL37 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.|||Belongs to the vinculin/alpha-catenin family.|||Cell membrane|||Membrane|||adherens junction|||podosome http://togogenome.org/gene/9483:RMND1 ^@ http://purl.uniprot.org/uniprot/A0A8I3WST0|||http://purl.uniprot.org/uniprot/F7FN68 ^@ Similarity ^@ Belongs to the RMD1/sif2 family. http://togogenome.org/gene/9483:TCAF1 ^@ http://purl.uniprot.org/uniprot/F7FXG5 ^@ Similarity ^@ Belongs to the TCAF family. http://togogenome.org/gene/9483:PSMC3IP ^@ http://purl.uniprot.org/uniprot/F7ISJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HOP2 family.|||Nucleus http://togogenome.org/gene/9483:GNRH1 ^@ http://purl.uniprot.org/uniprot/U3CDM8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GnRH family.|||Secreted|||Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones. http://togogenome.org/gene/9483:LOC100393949 ^@ http://purl.uniprot.org/uniprot/F7IT04 ^@ Similarity ^@ Belongs to the PRORSD1 family. http://togogenome.org/gene/9483:SUFU ^@ http://purl.uniprot.org/uniprot/F6U4B5|||http://purl.uniprot.org/uniprot/U3FX06 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SUFU family.|||Cytoplasm|||Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A).|||Nucleus http://togogenome.org/gene/9483:LOC100407762 ^@ http://purl.uniprot.org/uniprot/A0A8I3W090 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9483:LOC103796642 ^@ http://purl.uniprot.org/uniprot/A0A5F4VU17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-microseminoprotein family.|||Secreted http://togogenome.org/gene/9483:LOC100403294 ^@ http://purl.uniprot.org/uniprot/F7IFP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:EIF4ENIF1 ^@ http://purl.uniprot.org/uniprot/B0KWR5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:GLRA2 ^@ http://purl.uniprot.org/uniprot/U3CG39|||http://purl.uniprot.org/uniprot/U3FXG3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/9483:POMT2 ^@ http://purl.uniprot.org/uniprot/A0A8I3W598 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/9483:GAD1 ^@ http://purl.uniprot.org/uniprot/U3DTP3 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9483:NIT1 ^@ http://purl.uniprot.org/uniprot/U3BSW4 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. http://togogenome.org/gene/9483:ATF1 ^@ http://purl.uniprot.org/uniprot/A0A2R8P9U0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:C4BPA ^@ http://purl.uniprot.org/uniprot/F7IKA2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:DPY30 ^@ http://purl.uniprot.org/uniprot/F7IR99 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/9483:MPHOSPH10 ^@ http://purl.uniprot.org/uniprot/U3DY58 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MPP10 family.|||Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.|||nucleolus http://togogenome.org/gene/9483:GLRA1 ^@ http://purl.uniprot.org/uniprot/F6ZNX7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane|||dendrite http://togogenome.org/gene/9483:DOCK4 ^@ http://purl.uniprot.org/uniprot/U3CZS7|||http://purl.uniprot.org/uniprot/U3F8D9 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9483:PPFIBP2 ^@ http://purl.uniprot.org/uniprot/A0A5F4W4S2|||http://purl.uniprot.org/uniprot/U3EQ27 ^@ Similarity ^@ Belongs to the liprin family. Liprin-beta subfamily. http://togogenome.org/gene/9483:NUDCD1 ^@ http://purl.uniprot.org/uniprot/U3DVM1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9483:C2H5orf24 ^@ http://purl.uniprot.org/uniprot/F7DCU5|||http://purl.uniprot.org/uniprot/F7HZ39 ^@ Similarity ^@ Belongs to the UPF0461 family. http://togogenome.org/gene/9483:LOC100389093 ^@ http://purl.uniprot.org/uniprot/B0VXB5|||http://purl.uniprot.org/uniprot/Q9GJS7 ^@ Function|||Similarity|||Subunit|||Tissue Specificity ^@ Belongs to the globin family.|||Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.|||Heterotetramer of two alpha chains and two gamma chains in fetal hemoglobin (Hb F).|||Red blood cells. http://togogenome.org/gene/9483:CDC42 ^@ http://purl.uniprot.org/uniprot/F7HMJ4|||http://purl.uniprot.org/uniprot/U3DLZ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.|||Cell membrane|||Membrane|||Midbody|||Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. http://togogenome.org/gene/9483:SLC39A1 ^@ http://purl.uniprot.org/uniprot/U3BBV7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:XPA ^@ http://purl.uniprot.org/uniprot/U3DQN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPA family.|||Nucleus http://togogenome.org/gene/9483:MSR1 ^@ http://purl.uniprot.org/uniprot/F6QM72 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:SLC35A3 ^@ http://purl.uniprot.org/uniprot/A0A8I3WA46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:RASGRP1 ^@ http://purl.uniprot.org/uniprot/F7FFF2 ^@ Similarity ^@ Belongs to the RASGRP family. http://togogenome.org/gene/9483:HAPSTR1 ^@ http://purl.uniprot.org/uniprot/F7IJL5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:ETS1 ^@ http://purl.uniprot.org/uniprot/F7C4P4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:ST8SIA3 ^@ http://purl.uniprot.org/uniprot/F7I126 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9483:PRKCH ^@ http://purl.uniprot.org/uniprot/F7HD36 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis.|||Cytoplasm|||Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-513 (activation loop of the kinase domain), Thr-656 (turn motif) and Ser-675 (hydrophobic region), need to be phosphorylated for its full activation. http://togogenome.org/gene/9483:TM9SF2 ^@ http://purl.uniprot.org/uniprot/U3EFD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/9483:LOC100407094 ^@ http://purl.uniprot.org/uniprot/A0A5F4WMU4 ^@ Similarity|||Subunit ^@ Belongs to the GST superfamily. Mu family.|||Homodimer. http://togogenome.org/gene/9483:GUCY1A1 ^@ http://purl.uniprot.org/uniprot/F7IRP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Cytoplasm http://togogenome.org/gene/9483:LNPEP ^@ http://purl.uniprot.org/uniprot/A0A8I3W2L7|||http://purl.uniprot.org/uniprot/F7HKT3 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9483:STX1B ^@ http://purl.uniprot.org/uniprot/U3F4G9 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9483:SLC35B3 ^@ http://purl.uniprot.org/uniprot/A0A8I3W6G3|||http://purl.uniprot.org/uniprot/A0A8I3W9C9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/9483:NTSR2 ^@ http://purl.uniprot.org/uniprot/F6S1P8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:TMEM88B ^@ http://purl.uniprot.org/uniprot/F7GWG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM88 family.|||Membrane http://togogenome.org/gene/9483:CSNK1G3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XS38|||http://purl.uniprot.org/uniprot/F7DPL9|||http://purl.uniprot.org/uniprot/U3AVV3|||http://purl.uniprot.org/uniprot/U3E6K8|||http://purl.uniprot.org/uniprot/U3F5Z4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. http://togogenome.org/gene/9483:IFIH1 ^@ http://purl.uniprot.org/uniprot/F7IN54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/9483:LCMT1 ^@ http://purl.uniprot.org/uniprot/U3B7Q5 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. LCMT family.|||Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. http://togogenome.org/gene/9483:GDI1 ^@ http://purl.uniprot.org/uniprot/U3CX66 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP. http://togogenome.org/gene/9483:ANKRD34C ^@ http://purl.uniprot.org/uniprot/U3FA74 ^@ Similarity ^@ Belongs to the ANKRD34 family. http://togogenome.org/gene/9483:STC2 ^@ http://purl.uniprot.org/uniprot/F7E3T2 ^@ Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9483:SLC30A7 ^@ http://purl.uniprot.org/uniprot/F7DID4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Functions as a zinc transporter.|||Homooligomer.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9483:UBE2I ^@ http://purl.uniprot.org/uniprot/A0A2R8PFF1 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9483:OOSP2 ^@ http://purl.uniprot.org/uniprot/A0A2R8MBX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PLAC1 family.|||Secreted http://togogenome.org/gene/9483:XPNPEP2 ^@ http://purl.uniprot.org/uniprot/F7CGS9 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/9483:NMD3 ^@ http://purl.uniprot.org/uniprot/F7BFU8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.|||Belongs to the NMD3 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:GNPTAB ^@ http://purl.uniprot.org/uniprot/U3E781 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the stealth family.|||Membrane http://togogenome.org/gene/9483:E2F4 ^@ http://purl.uniprot.org/uniprot/F7BSL2|||http://purl.uniprot.org/uniprot/U3DRH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9483:SLC25A21 ^@ http://purl.uniprot.org/uniprot/U3BRH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9483:TP63 ^@ http://purl.uniprot.org/uniprot/A0A2R8P0K0|||http://purl.uniprot.org/uniprot/F7I720|||http://purl.uniprot.org/uniprot/F7I9D3|||http://purl.uniprot.org/uniprot/U3E412 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.|||Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.|||Belongs to the p53 family.|||Binds 1 zinc ion per subunit.|||Binds DNA as a homotetramer.|||Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:CCDC43 ^@ http://purl.uniprot.org/uniprot/F7HU86 ^@ Similarity ^@ Belongs to the CCDC43 family. http://togogenome.org/gene/9483:HOMEZ ^@ http://purl.uniprot.org/uniprot/F7IG63 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:LOC100398638 ^@ http://purl.uniprot.org/uniprot/F7F3A7 ^@ Similarity ^@ Belongs to the PRR20 family. http://togogenome.org/gene/9483:EPHA7 ^@ http://purl.uniprot.org/uniprot/F6XPG2|||http://purl.uniprot.org/uniprot/U3DW98 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:RPL21 ^@ http://purl.uniprot.org/uniprot/A0A2R8MC53 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/9483:NR1H3 ^@ http://purl.uniprot.org/uniprot/U3FGX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9483:GPR87 ^@ http://purl.uniprot.org/uniprot/A0A2R8MD25 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9483:YWHAB ^@ http://purl.uniprot.org/uniprot/U3F717 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9483:CAPZB ^@ http://purl.uniprot.org/uniprot/F7H329|||http://purl.uniprot.org/uniprot/F7H3P1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the F-actin-capping protein beta subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit.|||cytoskeleton|||sarcomere http://togogenome.org/gene/9483:DUS4L ^@ http://purl.uniprot.org/uniprot/F6RTL3 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. http://togogenome.org/gene/9483:C12H10orf53 ^@ http://purl.uniprot.org/uniprot/F7H8W0 ^@ Similarity ^@ Belongs to the UPF0728 family. http://togogenome.org/gene/9483:DEDD2 ^@ http://purl.uniprot.org/uniprot/U3D5N1 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9483:ADORA2A ^@ http://purl.uniprot.org/uniprot/A0A8I3X4X6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. http://togogenome.org/gene/9483:CBX5 ^@ http://purl.uniprot.org/uniprot/F7IG39 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:PML ^@ http://purl.uniprot.org/uniprot/F6SXY7|||http://purl.uniprot.org/uniprot/F6TV43 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:NR5A2 ^@ http://purl.uniprot.org/uniprot/A0A2R8MHR1|||http://purl.uniprot.org/uniprot/F7I1I4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR5 subfamily.|||Nucleus http://togogenome.org/gene/9483:P3H2 ^@ http://purl.uniprot.org/uniprot/F7HVC6 ^@ Similarity ^@ Belongs to the leprecan family. http://togogenome.org/gene/9483:TXN ^@ http://purl.uniprot.org/uniprot/Q9BDJ3|||http://purl.uniprot.org/uniprot/U3CTN3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thioredoxin family.|||Cytoplasm|||Homodimer; disulfide-linked. Interacts with TXNIP through the redox-active site. Interacts with MAP3K5 and CASP3. Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA-binding activity in a redox-dependent manner (By similarity).|||In the fully reduced protein, both Cys-69 and Cys-73 are nitrosylated in response to nitric oxide (NO). When two disulfide bonds are present in the protein, only Cys-73 is nitrosylated. Cys-73 can serve as donor for nitrosylation of target proteins (By similarity).|||Nucleus|||Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity).|||Secreted http://togogenome.org/gene/9483:TBL1XR1 ^@ http://purl.uniprot.org/uniprot/U3FNT4 ^@ Similarity ^@ Belongs to the WD repeat EBI family. http://togogenome.org/gene/9483:NPC2 ^@ http://purl.uniprot.org/uniprot/F7HX33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPC2 family.|||Secreted http://togogenome.org/gene/9483:LOC100400142 ^@ http://purl.uniprot.org/uniprot/F7FN63 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily.|||Cytoplasm|||Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.|||Nucleus|||Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions. http://togogenome.org/gene/9483:RAP1GDS1 ^@ http://purl.uniprot.org/uniprot/A0A5K1VHP6|||http://purl.uniprot.org/uniprot/U3FS21 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum|||Mitochondrion http://togogenome.org/gene/9483:GSK3A ^@ http://purl.uniprot.org/uniprot/F7HP16 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. http://togogenome.org/gene/9483:SLC27A5 ^@ http://purl.uniprot.org/uniprot/A0A8I3WP13 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9483:LMCD1 ^@ http://purl.uniprot.org/uniprot/A0A8I3WRW8|||http://purl.uniprot.org/uniprot/U3C7A7 ^@ Function|||Subunit ^@ Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN (By similarity). Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer.|||Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. http://togogenome.org/gene/9483:ZNF24 ^@ http://purl.uniprot.org/uniprot/F7HFP7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:PIPOX ^@ http://purl.uniprot.org/uniprot/F7GSN9 ^@ Similarity ^@ Belongs to the MSOX/MTOX family. http://togogenome.org/gene/9483:FABP2 ^@ http://purl.uniprot.org/uniprot/F7HKK2 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9483:ARMT1 ^@ http://purl.uniprot.org/uniprot/U3F6H0 ^@ Domain|||Function|||Similarity ^@ Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.|||Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.|||Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine. http://togogenome.org/gene/9483:CLPTM1 ^@ http://purl.uniprot.org/uniprot/U3FUB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLPTM1 family.|||Membrane http://togogenome.org/gene/9483:ANKZF1 ^@ http://purl.uniprot.org/uniprot/A0A5F4WEP3|||http://purl.uniprot.org/uniprot/F6QSL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ANKZF1/VMS1 family.|||Cytoplasm http://togogenome.org/gene/9483:GAP43 ^@ http://purl.uniprot.org/uniprot/A0A8I4A0D1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the neuromodulin family.|||Cell membrane|||Cytoplasm|||Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts (via IQ domain) with calmodulin. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.|||Membrane|||Palmitoylated. Palmitoylation is essential for plasma membrane association.|||Perikaryon|||Synapse|||This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.|||axon|||dendrite|||filopodium membrane|||growth cone membrane http://togogenome.org/gene/9483:PUS7L ^@ http://purl.uniprot.org/uniprot/A0A8I3WK96|||http://purl.uniprot.org/uniprot/F6S2V2 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruD family. http://togogenome.org/gene/9483:LSM6 ^@ http://purl.uniprot.org/uniprot/U3EDF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/9483:ERO1A ^@ http://purl.uniprot.org/uniprot/U3EXB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EROs family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9483:MFSD8 ^@ http://purl.uniprot.org/uniprot/F6V932|||http://purl.uniprot.org/uniprot/U3FT36 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:PLA2G5 ^@ http://purl.uniprot.org/uniprot/A0A8I3W0F9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9483:OLA1 ^@ http://purl.uniprot.org/uniprot/U3DTY5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.|||Cytoplasm|||Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.|||Monomer.|||Nucleus|||nucleolus http://togogenome.org/gene/9483:LOC100386748 ^@ http://purl.uniprot.org/uniprot/F7HYF5 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9483:NKX2-5 ^@ http://purl.uniprot.org/uniprot/A0A8I3X2B3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:HAUS3 ^@ http://purl.uniprot.org/uniprot/U3ESN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HAUS3 family.|||spindle http://togogenome.org/gene/9483:ZNF215 ^@ http://purl.uniprot.org/uniprot/F6YZN4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:UBA3 ^@ http://purl.uniprot.org/uniprot/F6QVE0|||http://purl.uniprot.org/uniprot/F6R524|||http://purl.uniprot.org/uniprot/U3DEY7 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.|||Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8. http://togogenome.org/gene/9483:RECQL5 ^@ http://purl.uniprot.org/uniprot/U3FTT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RecQ subfamily.|||Nucleus http://togogenome.org/gene/9483:CNMD ^@ http://purl.uniprot.org/uniprot/F7HB30 ^@ Similarity ^@ Belongs to the chondromodulin-1 family. http://togogenome.org/gene/9483:IL17C ^@ http://purl.uniprot.org/uniprot/A0A8I3WCW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/9483:GJA3 ^@ http://purl.uniprot.org/uniprot/A0A2R8P4Y0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9483:TBRG1 ^@ http://purl.uniprot.org/uniprot/U3F8Y8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:RNF146 ^@ http://purl.uniprot.org/uniprot/F7HB59 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Can form homooligomers. Interacts with PARsylated AXIN1, AXIN2, BLZF1, CASC3, H1-2, IPO7, LIG3, NCL, PARP1, XRCC1, XRCC5 and XRCC6. Interacts with DDB1, DHX15, IQGAP1, LRPPRC, PARP2, PRKDC, RUVBL2, TNKS1 and TNKS2. Binding often leads to interactor ubiquitination, in the presence of the appropriate E1 and E2 enzymes, and proteasomal degradation.|||E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.|||The WWE domain mediates non-covalent poly(ADP-ribose)-binding.|||Ubiquitinated; autoubiquitinated.|||cytosol http://togogenome.org/gene/9483:KCNE3 ^@ http://purl.uniprot.org/uniprot/A0A2R8MJA3 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/9483:HOXA1 ^@ http://purl.uniprot.org/uniprot/B0VXK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Labial subfamily.|||Nucleus http://togogenome.org/gene/9483:CD63 ^@ http://purl.uniprot.org/uniprot/U3CZ61 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Cell membrane|||Cell surface|||Endosome membrane|||Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.|||Late endosome membrane|||Lysosome membrane|||Melanosome|||Membrane|||extracellular exosome|||multivesicular body http://togogenome.org/gene/9483:PLD5 ^@ http://purl.uniprot.org/uniprot/A0A5F4WFM5|||http://purl.uniprot.org/uniprot/U3CMZ1 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/9483:SLC25A24 ^@ http://purl.uniprot.org/uniprot/U3F990 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9483:ERFL ^@ http://purl.uniprot.org/uniprot/F7GS67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9483:DONSON ^@ http://purl.uniprot.org/uniprot/U3DX17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DONSON family.|||Nucleus http://togogenome.org/gene/9483:SLC25A27 ^@ http://purl.uniprot.org/uniprot/A0A8I4A4E2|||http://purl.uniprot.org/uniprot/U3EW66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9483:LOC100385257 ^@ http://purl.uniprot.org/uniprot/U3D2S2 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9483:FES ^@ http://purl.uniprot.org/uniprot/F7IBY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.|||Cell membrane|||Membrane|||cytoskeleton http://togogenome.org/gene/9483:AKAP8L ^@ http://purl.uniprot.org/uniprot/U3CVL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AKAP95 family.|||Nucleus matrix http://togogenome.org/gene/9483:NKAIN1 ^@ http://purl.uniprot.org/uniprot/U3EGE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NKAIN family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:ANXA1 ^@ http://purl.uniprot.org/uniprot/F7IL52 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Basolateral cell membrane|||Belongs to the annexin family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Early endosome|||Endosome membrane|||Lateral cell membrane|||Membrane|||Nucleus|||The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.|||cilium|||extracellular exosome|||extracellular space|||phagocytic cup|||secretory vesicle lumen http://togogenome.org/gene/9483:TARS1 ^@ http://purl.uniprot.org/uniprot/U3FHJ0 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9483:LHX9 ^@ http://purl.uniprot.org/uniprot/F7I3D2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:DYNLL1 ^@ http://purl.uniprot.org/uniprot/F6UCC7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.|||Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/9483:OCEL1 ^@ http://purl.uniprot.org/uniprot/F7IEP3 ^@ Similarity ^@ Belongs to the ELL/occludin family. http://togogenome.org/gene/9483:NEUROD1 ^@ http://purl.uniprot.org/uniprot/F6SAJ7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:TP53 ^@ http://purl.uniprot.org/uniprot/F7GNX0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.|||Belongs to the p53 family.|||Binds 1 zinc ion per subunit.|||Binds DNA as a homotetramer.|||Cytoplasm|||Endoplasmic reticulum|||Mitochondrion matrix|||Nucleus|||PML body|||centrosome http://togogenome.org/gene/9483:OXSM ^@ http://purl.uniprot.org/uniprot/U3EWR6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.|||Mitochondrion http://togogenome.org/gene/9483:LOC100414020 ^@ http://purl.uniprot.org/uniprot/A0A5F4W5M3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/9483:ELP3 ^@ http://purl.uniprot.org/uniprot/F6Z4B9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ELP3 family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. http://togogenome.org/gene/9483:RPL35A ^@ http://purl.uniprot.org/uniprot/A0A8I3W0W2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL33 family. http://togogenome.org/gene/9483:RIN2 ^@ http://purl.uniprot.org/uniprot/A0A8I3WPG1|||http://purl.uniprot.org/uniprot/A0A8I4A235 ^@ Similarity ^@ Belongs to the RIN (Ras interaction/interference) family. http://togogenome.org/gene/9483:PELO ^@ http://purl.uniprot.org/uniprot/U3C932 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, pelo recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel.|||Cytoplasm http://togogenome.org/gene/9483:LOC100400493 ^@ http://purl.uniprot.org/uniprot/F7IFF1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:CHRDL2 ^@ http://purl.uniprot.org/uniprot/A0A8I4A384 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9483:FAS ^@ http://purl.uniprot.org/uniprot/A8WEX9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane raft http://togogenome.org/gene/9483:TMEM150A ^@ http://purl.uniprot.org/uniprot/F7FKV8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:BTD ^@ http://purl.uniprot.org/uniprot/F7ED31 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. http://togogenome.org/gene/9483:DPAGT1 ^@ http://purl.uniprot.org/uniprot/F6VZ52 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family.|||Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:STAM ^@ http://purl.uniprot.org/uniprot/F7E7C6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the STAM family.|||Early endosome membrane|||Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. http://togogenome.org/gene/9483:NBL1 ^@ http://purl.uniprot.org/uniprot/A0A8I3W5B0|||http://purl.uniprot.org/uniprot/F7HWY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Secreted http://togogenome.org/gene/9483:NEUROD6 ^@ http://purl.uniprot.org/uniprot/F6W8P8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:CRH ^@ http://purl.uniprot.org/uniprot/F7I0T1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Secreted http://togogenome.org/gene/9483:TIMP1 ^@ http://purl.uniprot.org/uniprot/U3CUE7 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/9483:NAP1L1 ^@ http://purl.uniprot.org/uniprot/A0A5F4WE21 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9483:CLSTN2 ^@ http://purl.uniprot.org/uniprot/F7GNK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calsyntenin family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Postsynaptic cell membrane http://togogenome.org/gene/9483:LCLAT1 ^@ http://purl.uniprot.org/uniprot/A0A2R8MKZ9 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9483:OGT ^@ http://purl.uniprot.org/uniprot/F7G0L9|||http://purl.uniprot.org/uniprot/U3EFN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.|||Cell projection|||Mitochondrion membrane http://togogenome.org/gene/9483:CROT ^@ http://purl.uniprot.org/uniprot/F7ENF8 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/9483:DCP2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y249|||http://purl.uniprot.org/uniprot/U3C2I7 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DCP2 subfamily. http://togogenome.org/gene/9483:ADAMTS6 ^@ http://purl.uniprot.org/uniprot/F7B3K4 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9483:PLOD2 ^@ http://purl.uniprot.org/uniprot/U3CUC8|||http://purl.uniprot.org/uniprot/U3E4Z2 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9483:SMARCD1 ^@ http://purl.uniprot.org/uniprot/F7FTP4|||http://purl.uniprot.org/uniprot/F7G3A0 ^@ Similarity ^@ Belongs to the SMARCD family. http://togogenome.org/gene/9483:UPK1B ^@ http://purl.uniprot.org/uniprot/F7BN59 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:SPON1 ^@ http://purl.uniprot.org/uniprot/F7G1Q5 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9483:SELE ^@ http://purl.uniprot.org/uniprot/F7F2X2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the selectin/LECAM family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:STXBP1 ^@ http://purl.uniprot.org/uniprot/F6SYW8|||http://purl.uniprot.org/uniprot/F7IMD1 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9483:BMP8A ^@ http://purl.uniprot.org/uniprot/F7IM63 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9483:SMC1B ^@ http://purl.uniprot.org/uniprot/F6RQV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC1 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/9483:UCP1 ^@ http://purl.uniprot.org/uniprot/F7HVY5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||May undergo ubiquitin-mediated proteasomal degradation.|||Membrane|||Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:TGM3 ^@ http://purl.uniprot.org/uniprot/F7IIF1 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9483:BCOR ^@ http://purl.uniprot.org/uniprot/A0A8J8XZ08 ^@ Similarity ^@ Belongs to the BCOR family. http://togogenome.org/gene/9483:TMEM135 ^@ http://purl.uniprot.org/uniprot/U3EST0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM135 family.|||Membrane http://togogenome.org/gene/9483:CLGN ^@ http://purl.uniprot.org/uniprot/A0A5F4VT31 ^@ Similarity ^@ Belongs to the calreticulin family. http://togogenome.org/gene/9483:PRCP ^@ http://purl.uniprot.org/uniprot/A0A8I3X9G7 ^@ Similarity ^@ Belongs to the peptidase S28 family. http://togogenome.org/gene/9483:SCGB2A1 ^@ http://purl.uniprot.org/uniprot/F7HX07 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9483:ANXA8L1 ^@ http://purl.uniprot.org/uniprot/A0A2R8NCV0 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9483:AHR ^@ http://purl.uniprot.org/uniprot/F6X3Y4 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9483:PLRG1 ^@ http://purl.uniprot.org/uniprot/U3DWJ5 ^@ Similarity ^@ Belongs to the WD repeat PRL1/PRL2 family. http://togogenome.org/gene/9483:TSPAN5 ^@ http://purl.uniprot.org/uniprot/F6X7Z8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9483:F2R ^@ http://purl.uniprot.org/uniprot/U3F0Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:JOSD2 ^@ http://purl.uniprot.org/uniprot/U3DD69 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:LOX ^@ http://purl.uniprot.org/uniprot/A0A2R8MXE7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/9483:TAF10 ^@ http://purl.uniprot.org/uniprot/F7AXR1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF10 family.|||Nucleus|||The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. http://togogenome.org/gene/9483:RBL2 ^@ http://purl.uniprot.org/uniprot/U3FTM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the retinoblastoma protein (RB) family.|||Nucleus http://togogenome.org/gene/9483:C6H2orf76 ^@ http://purl.uniprot.org/uniprot/F7EYC0 ^@ Similarity ^@ Belongs to the UPF0538 family. http://togogenome.org/gene/9483:GAMT ^@ http://purl.uniprot.org/uniprot/U3D5X2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.|||Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor.|||Monomer. http://togogenome.org/gene/9483:SNX1 ^@ http://purl.uniprot.org/uniprot/F7I414 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome membrane|||Endosome membrane|||Membrane|||lamellipodium|||trans-Golgi network membrane http://togogenome.org/gene/9483:VXN ^@ http://purl.uniprot.org/uniprot/U3E0B5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vexin family.|||Cell membrane|||Membrane|||Nucleus http://togogenome.org/gene/9483:ADGRB3 ^@ http://purl.uniprot.org/uniprot/U3DYQ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:PLPPR2 ^@ http://purl.uniprot.org/uniprot/U3EB96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9483:PRKAR1A ^@ http://purl.uniprot.org/uniprot/U3F3H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:DCTPP1 ^@ http://purl.uniprot.org/uniprot/U3E7J8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Homotetramer.|||Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.|||cytosol http://togogenome.org/gene/9483:TBX21 ^@ http://purl.uniprot.org/uniprot/A0A2R8MZJ4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9483:ATL1 ^@ http://purl.uniprot.org/uniprot/U3EKI1 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9483:PARP1 ^@ http://purl.uniprot.org/uniprot/U3DZQ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARTD/PARP family.|||Chromosome|||Interacts (when auto-poly-ADP-ribosylated) with AIFM1.|||Nucleus|||Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair.|||This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. http://togogenome.org/gene/9483:OLFR651 ^@ http://purl.uniprot.org/uniprot/B0VXD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:SF3A3 ^@ http://purl.uniprot.org/uniprot/F6YRE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3A3 family.|||Nucleus http://togogenome.org/gene/9483:LOC100388165 ^@ http://purl.uniprot.org/uniprot/F7I4U5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9483:SNX30 ^@ http://purl.uniprot.org/uniprot/U3F1I2 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9483:TMEM54 ^@ http://purl.uniprot.org/uniprot/F7BVY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM54 family.|||Membrane http://togogenome.org/gene/9483:FAM151A ^@ http://purl.uniprot.org/uniprot/F6UFE2 ^@ Similarity ^@ Belongs to the FAM151 family. http://togogenome.org/gene/9483:NOX1 ^@ http://purl.uniprot.org/uniprot/U3BPB7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:MCMBP ^@ http://purl.uniprot.org/uniprot/U3E9M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCMBP family.|||Nucleus http://togogenome.org/gene/9483:TFAP2A ^@ http://purl.uniprot.org/uniprot/A0A8I3W3Z2|||http://purl.uniprot.org/uniprot/F7G4A7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AP-2 family.|||Nucleus http://togogenome.org/gene/9483:RPL36A ^@ http://purl.uniprot.org/uniprot/F7IHF9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/9483:PIERCE1 ^@ http://purl.uniprot.org/uniprot/U3FKY6 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.|||cilium axoneme http://togogenome.org/gene/9483:SFMBT1 ^@ http://purl.uniprot.org/uniprot/F7BZT4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:STX6 ^@ http://purl.uniprot.org/uniprot/F6ZQT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Golgi apparatus membrane http://togogenome.org/gene/9483:LOC100385521 ^@ http://purl.uniprot.org/uniprot/A0A5F4WK63 ^@ Similarity ^@ Belongs to the gonadal family. http://togogenome.org/gene/9483:PPFIA2 ^@ http://purl.uniprot.org/uniprot/U3CJ29|||http://purl.uniprot.org/uniprot/U3EZ11|||http://purl.uniprot.org/uniprot/U3F7N7 ^@ Similarity ^@ Belongs to the liprin family. Liprin-alpha subfamily. http://togogenome.org/gene/9483:DICER1 ^@ http://purl.uniprot.org/uniprot/F6W4T4 ^@ Function|||Similarity ^@ Belongs to the helicase family. Dicer subfamily.|||Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. http://togogenome.org/gene/9483:NUDT3 ^@ http://purl.uniprot.org/uniprot/F6UJG1 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DIPP subfamily. http://togogenome.org/gene/9483:GRPEL2 ^@ http://purl.uniprot.org/uniprot/U3BNI4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GrpE family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion matrix http://togogenome.org/gene/9483:LOC100385103 ^@ http://purl.uniprot.org/uniprot/F6R8W5|||http://purl.uniprot.org/uniprot/F7GYJ8|||http://purl.uniprot.org/uniprot/U3B2I5 ^@ Similarity ^@ Belongs to the GroES chaperonin family.|||Belongs to the MOB1/phocein family. http://togogenome.org/gene/9483:JAKMIP2 ^@ http://purl.uniprot.org/uniprot/U3CMM4 ^@ Similarity ^@ Belongs to the JAKMIP family. http://togogenome.org/gene/9483:RIMKLB ^@ http://purl.uniprot.org/uniprot/F6ZQC0 ^@ Similarity ^@ Belongs to the RimK family. http://togogenome.org/gene/9483:MTHFS ^@ http://purl.uniprot.org/uniprot/U3CWB8 ^@ Similarity ^@ Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. http://togogenome.org/gene/9483:MTMR4 ^@ http://purl.uniprot.org/uniprot/U3DNI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/9483:VTI1A ^@ http://purl.uniprot.org/uniprot/A0A2R8MZ66|||http://purl.uniprot.org/uniprot/F7IIA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/9483:PPP2R3C ^@ http://purl.uniprot.org/uniprot/F7EHK2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:RCE1 ^@ http://purl.uniprot.org/uniprot/U3EM47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase U48 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:CREG1 ^@ http://purl.uniprot.org/uniprot/U3FJ83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CREG family.|||Secreted http://togogenome.org/gene/9483:PKIA ^@ http://purl.uniprot.org/uniprot/A0A8I3WG41 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/9483:LMLN ^@ http://purl.uniprot.org/uniprot/A0A8J8XWA4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M8 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9483:LOC100401782 ^@ http://purl.uniprot.org/uniprot/F7DMR1 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9483:EEF1G ^@ http://purl.uniprot.org/uniprot/U3FNE8 ^@ Function|||Subunit ^@ EF-1 is composed of four subunits: alpha, beta, delta, and gamma.|||Probably plays a role in anchoring the complex to other cellular components. http://togogenome.org/gene/9483:RET ^@ http://purl.uniprot.org/uniprot/F7I536 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane|||Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. http://togogenome.org/gene/9483:MRPL33 ^@ http://purl.uniprot.org/uniprot/U3CMP0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/9483:ETV3 ^@ http://purl.uniprot.org/uniprot/F7EJE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9483:NDUFA2 ^@ http://purl.uniprot.org/uniprot/A0A2R8N2P0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA2 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:RNF114 ^@ http://purl.uniprot.org/uniprot/F6U6P9 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.|||Nucleus http://togogenome.org/gene/9483:RALY ^@ http://purl.uniprot.org/uniprot/F6ZUD9|||http://purl.uniprot.org/uniprot/U3EXQ5 ^@ Similarity ^@ Belongs to the RRM HNRPC family. RALY subfamily. http://togogenome.org/gene/9483:PBX3 ^@ http://purl.uniprot.org/uniprot/F6YSM0|||http://purl.uniprot.org/uniprot/F6ZJS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/PBX homeobox family.|||Nucleus http://togogenome.org/gene/9483:SLC9A9 ^@ http://purl.uniprot.org/uniprot/U3BWW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/9483:F2RL3 ^@ http://purl.uniprot.org/uniprot/F7IPB8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9483:SMYD2 ^@ http://purl.uniprot.org/uniprot/U3FFG0 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.|||cytosol http://togogenome.org/gene/9483:CALCA ^@ http://purl.uniprot.org/uniprot/U3EPP1 ^@ Similarity ^@ Belongs to the calcitonin family. http://togogenome.org/gene/9483:LOC100407286 ^@ http://purl.uniprot.org/uniprot/U3E4E5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:BUD31 ^@ http://purl.uniprot.org/uniprot/F7I7X2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BUD31 (G10) family.|||Nucleus http://togogenome.org/gene/9483:OR10G3 ^@ http://purl.uniprot.org/uniprot/F7G5T7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:SHBG ^@ http://purl.uniprot.org/uniprot/F7E805 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:BRINP1 ^@ http://purl.uniprot.org/uniprot/F6YUW3 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/9483:CAT ^@ http://purl.uniprot.org/uniprot/Q2I6W4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the catalase family.|||Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.|||Homotetramer. Interacts (via microbody targeting signal) with PEX5, monomeric form interacts with PEX5, leading to its translocation into peroxisomes.|||Peroxisome http://togogenome.org/gene/9483:EIF1 ^@ http://purl.uniprot.org/uniprot/A0A2R8M2V6 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/9483:SST ^@ http://purl.uniprot.org/uniprot/F7IIT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatostatin family.|||Secreted http://togogenome.org/gene/9483:POU4F2 ^@ http://purl.uniprot.org/uniprot/F6W7V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/9483:ADAMTS1 ^@ http://purl.uniprot.org/uniprot/F6X3H6 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9483:CDK4 ^@ http://purl.uniprot.org/uniprot/F7DPY6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:PTN ^@ http://purl.uniprot.org/uniprot/U3F5N5 ^@ Similarity ^@ Belongs to the pleiotrophin family. http://togogenome.org/gene/9483:PNPLA7 ^@ http://purl.uniprot.org/uniprot/U3FPM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NTE family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:AMFR ^@ http://purl.uniprot.org/uniprot/U3DJU5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:MRAP2 ^@ http://purl.uniprot.org/uniprot/F7HEG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRAP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:LOC100385449 ^@ http://purl.uniprot.org/uniprot/H9KXI8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9483:HTR7 ^@ http://purl.uniprot.org/uniprot/U3E1W7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:FZD2 ^@ http://purl.uniprot.org/uniprot/A0A2R8MXI9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:TSR1 ^@ http://purl.uniprot.org/uniprot/U3EBS8 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9483:KCNH5 ^@ http://purl.uniprot.org/uniprot/A0A8I3WZX1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:TAS2R8 ^@ http://purl.uniprot.org/uniprot/A0A8I3WVY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9483:HTR1D ^@ http://purl.uniprot.org/uniprot/F6V9Y1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Homodimer. Heterodimer with HTR1B.|||Membrane http://togogenome.org/gene/9483:DLX1 ^@ http://purl.uniprot.org/uniprot/A0A2R8N712 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:RETN ^@ http://purl.uniprot.org/uniprot/A0A8I3W9M9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the resistin/FIZZ family.|||Secreted http://togogenome.org/gene/9483:KCNK10 ^@ http://purl.uniprot.org/uniprot/F7IJI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9483:LOC108593825 ^@ http://purl.uniprot.org/uniprot/A0A8I3WKX0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/9483:LDLRAD3 ^@ http://purl.uniprot.org/uniprot/U3C0H8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:TK1 ^@ http://purl.uniprot.org/uniprot/U3DTW2 ^@ Similarity ^@ Belongs to the thymidine kinase family. http://togogenome.org/gene/9483:SLC4A4 ^@ http://purl.uniprot.org/uniprot/U3CFQ7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9483:DDR2 ^@ http://purl.uniprot.org/uniprot/U3DLY1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:MRE11 ^@ http://purl.uniprot.org/uniprot/U3CS03|||http://purl.uniprot.org/uniprot/U3E822 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MRE11/RAD32 family.|||Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.|||Nucleus http://togogenome.org/gene/9483:SH3GLB1 ^@ http://purl.uniprot.org/uniprot/F7AEZ1|||http://purl.uniprot.org/uniprot/F7BKI7|||http://purl.uniprot.org/uniprot/U3CI10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Golgi apparatus membrane|||Midbody|||Mitochondrion outer membrane|||autophagosome membrane http://togogenome.org/gene/9483:FAM110A ^@ http://purl.uniprot.org/uniprot/F7I204 ^@ Similarity ^@ Belongs to the FAM110 family. http://togogenome.org/gene/9483:LOC100385852 ^@ http://purl.uniprot.org/uniprot/B0VXD3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRIM/RBCC family.|||Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:E2F2 ^@ http://purl.uniprot.org/uniprot/F7IIE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9483:GAS8 ^@ http://purl.uniprot.org/uniprot/F6RWJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC4 family.|||flagellum|||flagellum axoneme http://togogenome.org/gene/9483:ITGB3 ^@ http://purl.uniprot.org/uniprot/U3B9A7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:MRPL24 ^@ http://purl.uniprot.org/uniprot/F7IIC7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/9483:CRIPT ^@ http://purl.uniprot.org/uniprot/F6UYR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRIPT family.|||Cytoplasm http://togogenome.org/gene/9483:S1PR5 ^@ http://purl.uniprot.org/uniprot/F6QIC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:CPO ^@ http://purl.uniprot.org/uniprot/F7IIG5 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9483:SDAD1 ^@ http://purl.uniprot.org/uniprot/U3D3A8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SDA1 family.|||Required for 60S pre-ribosomal subunits export to the cytoplasm.|||nucleolus http://togogenome.org/gene/9483:HMGB3 ^@ http://purl.uniprot.org/uniprot/F6RM23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/9483:SLC27A4 ^@ http://purl.uniprot.org/uniprot/U3C442 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9483:SH3YL1 ^@ http://purl.uniprot.org/uniprot/U3AVX4 ^@ Similarity|||Subunit ^@ Belongs to the SH3YL1 family.|||Interacts with SH3D19. http://togogenome.org/gene/9483:UCKL1 ^@ http://purl.uniprot.org/uniprot/F6TEI4|||http://purl.uniprot.org/uniprot/F6VUW7|||http://purl.uniprot.org/uniprot/U3DT03 ^@ Similarity ^@ Belongs to the uridine kinase family. http://togogenome.org/gene/9483:MRPL22 ^@ http://purl.uniprot.org/uniprot/U3BBJ6|||http://purl.uniprot.org/uniprot/U3CDI0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/9483:GOSR2 ^@ http://purl.uniprot.org/uniprot/U3DCE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOSR2 family.|||Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.|||Membrane http://togogenome.org/gene/9483:CYLD ^@ http://purl.uniprot.org/uniprot/U3BXL9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||centrosome|||cilium basal body|||perinuclear region|||spindle http://togogenome.org/gene/9483:LOC100412398 ^@ http://purl.uniprot.org/uniprot/B0VXC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:RARS1 ^@ http://purl.uniprot.org/uniprot/A0A8I3WXP7 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9483:GLCE ^@ http://purl.uniprot.org/uniprot/A0A2R8MWH6 ^@ Similarity ^@ Belongs to the D-glucuronyl C5-epimerase family. http://togogenome.org/gene/9483:MAP2K6 ^@ http://purl.uniprot.org/uniprot/U3FRL0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:ARPC5L ^@ http://purl.uniprot.org/uniprot/U3DAD1 ^@ Function|||Similarity ^@ Belongs to the ARPC5 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. http://togogenome.org/gene/9483:B3GNT5 ^@ http://purl.uniprot.org/uniprot/F7IAI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:TMA7 ^@ http://purl.uniprot.org/uniprot/A0A8I3WZZ0 ^@ Similarity ^@ Belongs to the TMA7 family. http://togogenome.org/gene/9483:ACKR3 ^@ http://purl.uniprot.org/uniprot/F7HZX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:DDX50 ^@ http://purl.uniprot.org/uniprot/F7I8W5 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily. http://togogenome.org/gene/9483:LOC100410178 ^@ http://purl.uniprot.org/uniprot/A0A2R8MSK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:LOC100398454 ^@ http://purl.uniprot.org/uniprot/F7I4P0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TBCC family.|||Cytoplasm|||Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state. http://togogenome.org/gene/9483:NPAS4 ^@ http://purl.uniprot.org/uniprot/F6WSP4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:HSPA14 ^@ http://purl.uniprot.org/uniprot/U3BDK8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 70 family.|||Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.|||Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.|||cytosol http://togogenome.org/gene/9483:ARID5B ^@ http://purl.uniprot.org/uniprot/A0A5F4VT45|||http://purl.uniprot.org/uniprot/U3DDH1 ^@ Similarity ^@ Belongs to the ARID5B family. http://togogenome.org/gene/9483:MTRFR ^@ http://purl.uniprot.org/uniprot/F6Y5X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Mitochondrion http://togogenome.org/gene/9483:PSMA1 ^@ http://purl.uniprot.org/uniprot/F7GW13 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9483:TUBB1 ^@ http://purl.uniprot.org/uniprot/A0A8I3W422|||http://purl.uniprot.org/uniprot/F7I1T7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9483:MTMR1 ^@ http://purl.uniprot.org/uniprot/A0A5F4VTC2|||http://purl.uniprot.org/uniprot/A0A8I4A3H4|||http://purl.uniprot.org/uniprot/F6S6Y4|||http://purl.uniprot.org/uniprot/F7I3L6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/9483:WDR12 ^@ http://purl.uniprot.org/uniprot/U3B9L7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat WDR12/YTM1 family.|||Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.|||Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9483:IRAK2 ^@ http://purl.uniprot.org/uniprot/U3F779 ^@ Function|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.|||Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.|||Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. http://togogenome.org/gene/9483:NDST1 ^@ http://purl.uniprot.org/uniprot/F7HGK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/9483:NIPSNAP3A ^@ http://purl.uniprot.org/uniprot/F7C559 ^@ Similarity ^@ Belongs to the NipSnap family. http://togogenome.org/gene/9483:OPTN ^@ http://purl.uniprot.org/uniprot/A0A5K1UNZ7|||http://purl.uniprot.org/uniprot/F7I7M0 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Golgi apparatus|||May act by regulating membrane trafficking and cellular morphogenesis.|||Recycling endosome|||autophagosome|||perinuclear region|||trans-Golgi network http://togogenome.org/gene/9483:HMGCR ^@ http://purl.uniprot.org/uniprot/F7IAE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMG-CoA reductase family.|||Endoplasmic reticulum membrane|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9483:SERF2 ^@ http://purl.uniprot.org/uniprot/A0A5F4VW37 ^@ Similarity ^@ Belongs to the SERF family. http://togogenome.org/gene/9483:LOC100399827 ^@ http://purl.uniprot.org/uniprot/F7DH04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:SMPD3 ^@ http://purl.uniprot.org/uniprot/F6ZLI1 ^@ Similarity ^@ Belongs to the neutral sphingomyelinase family. http://togogenome.org/gene/9483:LOC100391380 ^@ http://purl.uniprot.org/uniprot/F7HAR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:MYORG ^@ http://purl.uniprot.org/uniprot/U3CW44 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/9483:BZW2 ^@ http://purl.uniprot.org/uniprot/U3DY16 ^@ Similarity ^@ Belongs to the BZW family. http://togogenome.org/gene/9483:LOC100400561 ^@ http://purl.uniprot.org/uniprot/F7I4G8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:PLK3 ^@ http://purl.uniprot.org/uniprot/U3D713 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. http://togogenome.org/gene/9483:CXCL10 ^@ http://purl.uniprot.org/uniprot/A0A2R8MWC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9483:OR4D5 ^@ http://purl.uniprot.org/uniprot/F7IT60 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:NAA60 ^@ http://purl.uniprot.org/uniprot/F7D7P8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:CDC37 ^@ http://purl.uniprot.org/uniprot/F7GXW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC37 family.|||Cytoplasm http://togogenome.org/gene/9483:TINAGL1 ^@ http://purl.uniprot.org/uniprot/F7HD12 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/9483:TBX10 ^@ http://purl.uniprot.org/uniprot/U3EAC5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9483:GBE1 ^@ http://purl.uniprot.org/uniprot/F7GS69 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. http://togogenome.org/gene/9483:ADISSP ^@ http://purl.uniprot.org/uniprot/F7FSS4 ^@ Similarity ^@ Belongs to the ADISSP family. http://togogenome.org/gene/9483:AK4 ^@ http://purl.uniprot.org/uniprot/F7GT48 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK3 subfamily.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP/ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP/ATP hydrolysis.|||Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.|||Mitochondrion matrix|||Monomer. http://togogenome.org/gene/9483:MYOZ1 ^@ http://purl.uniprot.org/uniprot/F7I6S9 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/9483:STK11IP ^@ http://purl.uniprot.org/uniprot/B0KWJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STK11IP family.|||Cytoplasm http://togogenome.org/gene/9483:PGM2 ^@ http://purl.uniprot.org/uniprot/U3FIK5 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/9483:AMIGO1 ^@ http://purl.uniprot.org/uniprot/F7ILS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. AMIGO family.|||Membrane http://togogenome.org/gene/9483:GCG ^@ http://purl.uniprot.org/uniprot/F7ID40 ^@ Similarity ^@ Belongs to the glucagon family. http://togogenome.org/gene/9483:SEPTIN11 ^@ http://purl.uniprot.org/uniprot/U3EPD7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9483:LOC100414177 ^@ http://purl.uniprot.org/uniprot/F6R067 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG10 glucosyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:STK17A ^@ http://purl.uniprot.org/uniprot/U3B905 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:ABI1 ^@ http://purl.uniprot.org/uniprot/F7I891|||http://purl.uniprot.org/uniprot/U3CMW2|||http://purl.uniprot.org/uniprot/U3CY87|||http://purl.uniprot.org/uniprot/U3EDP8|||http://purl.uniprot.org/uniprot/U3ELE5|||http://purl.uniprot.org/uniprot/U3EP75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABI family.|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/9483:PPP1R2 ^@ http://purl.uniprot.org/uniprot/F6ZFQ3 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 2 family. http://togogenome.org/gene/9483:ZNF394 ^@ http://purl.uniprot.org/uniprot/U3BRZ8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:MPP7 ^@ http://purl.uniprot.org/uniprot/F7GFG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||adherens junction|||tight junction http://togogenome.org/gene/9483:COG2 ^@ http://purl.uniprot.org/uniprot/U3FQL4 ^@ Similarity ^@ Belongs to the COG2 family. http://togogenome.org/gene/9483:LOC100386936 ^@ http://purl.uniprot.org/uniprot/F6TU06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-defensin family.|||Secreted http://togogenome.org/gene/9483:TSSK6 ^@ http://purl.uniprot.org/uniprot/H9KXW8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:GLRX ^@ http://purl.uniprot.org/uniprot/F7HFZ7 ^@ Function|||Similarity ^@ Belongs to the glutaredoxin family.|||Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. http://togogenome.org/gene/9483:RGMB ^@ http://purl.uniprot.org/uniprot/U3DJI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the repulsive guidance molecule (RGM) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:KDM5B ^@ http://purl.uniprot.org/uniprot/F7HNX8 ^@ Similarity ^@ Belongs to the JARID1 histone demethylase family. http://togogenome.org/gene/9483:ADD1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XYQ9|||http://purl.uniprot.org/uniprot/U3E195|||http://purl.uniprot.org/uniprot/U3F0E8 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/9483:SLC16A9 ^@ http://purl.uniprot.org/uniprot/F6SCZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:TBR1 ^@ http://purl.uniprot.org/uniprot/A0A8I3W3Z3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9483:LOC100397654 ^@ http://purl.uniprot.org/uniprot/U3DMU3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic AdoMetDC family.|||Binds 1 pyruvoyl group covalently per subunit.|||Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.|||Heterotetramer of two alpha and two beta chains. http://togogenome.org/gene/9483:CYP3A90 ^@ http://purl.uniprot.org/uniprot/B1NL96 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9483:RPL37 ^@ http://purl.uniprot.org/uniprot/F6YVB8 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/9483:LOC100390127 ^@ http://purl.uniprot.org/uniprot/F7DXQ1 ^@ Function|||Similarity ^@ Belongs to the cytochrome c oxidase subunit 6B.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. http://togogenome.org/gene/9483:NCSTN ^@ http://purl.uniprot.org/uniprot/U3CT98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nicastrin family.|||Membrane http://togogenome.org/gene/9483:PCYOX1L ^@ http://purl.uniprot.org/uniprot/U3EWX0 ^@ Similarity ^@ Belongs to the prenylcysteine oxidase family. http://togogenome.org/gene/9483:TAS2R38 ^@ http://purl.uniprot.org/uniprot/F7BJT1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane|||Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. http://togogenome.org/gene/9483:NUP155 ^@ http://purl.uniprot.org/uniprot/U3FK31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the non-repetitive/WGA-negative nucleoporin family.|||nuclear pore complex http://togogenome.org/gene/9483:TYW3 ^@ http://purl.uniprot.org/uniprot/U3FUS8 ^@ Function|||Similarity ^@ Belongs to the TYW3 family.|||Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. http://togogenome.org/gene/9483:KIAA1191 ^@ http://purl.uniprot.org/uniprot/F7HYZ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P33MONOX family.|||Cytoplasm|||Interacts with NELFB, NOL12 and PRNP.|||Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth. http://togogenome.org/gene/9483:LOC103795827 ^@ http://purl.uniprot.org/uniprot/F7FEM2|||http://purl.uniprot.org/uniprot/U3BWZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX16 family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9483:MIS18A ^@ http://purl.uniprot.org/uniprot/F6VMZ4 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.|||centromere http://togogenome.org/gene/9483:VPS25 ^@ http://purl.uniprot.org/uniprot/U3CTP5 ^@ Similarity ^@ Belongs to the VPS25 family. http://togogenome.org/gene/9483:RPL36 ^@ http://purl.uniprot.org/uniprot/F7IRR7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL36 family. http://togogenome.org/gene/9483:GNAL ^@ http://purl.uniprot.org/uniprot/F7I640 ^@ Similarity ^@ Belongs to the G-alpha family. G(s) subfamily. http://togogenome.org/gene/9483:ASB11 ^@ http://purl.uniprot.org/uniprot/F6R7Q4|||http://purl.uniprot.org/uniprot/F6RIQ7 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9483:LTB ^@ http://purl.uniprot.org/uniprot/F7I2U6 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9483:FRG1 ^@ http://purl.uniprot.org/uniprot/F6QHV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FRG1 family.|||Cajal body|||nucleolus http://togogenome.org/gene/9483:RRH ^@ http://purl.uniprot.org/uniprot/F6RXG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9483:SLC25A42 ^@ http://purl.uniprot.org/uniprot/F6R5T4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9483:SERPINA6 ^@ http://purl.uniprot.org/uniprot/F7IEE1 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9483:DOHH ^@ http://purl.uniprot.org/uniprot/F7HA65 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the deoxyhypusine hydroxylase family.|||Binds 2 Fe(2+) ions per subunit.|||Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor. http://togogenome.org/gene/9483:PLAA ^@ http://purl.uniprot.org/uniprot/U3CVU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat PLAP family.|||Cytoplasm http://togogenome.org/gene/9483:LOC100404859 ^@ http://purl.uniprot.org/uniprot/A0A2R8MBJ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase IV family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9483:SLC27A6 ^@ http://purl.uniprot.org/uniprot/F7H7P5 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9483:PIGU ^@ http://purl.uniprot.org/uniprot/A0A8J8YIQ4|||http://purl.uniprot.org/uniprot/U3EYS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGU family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:MTMR2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YGY6|||http://purl.uniprot.org/uniprot/U3CLW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/9483:SPG7 ^@ http://purl.uniprot.org/uniprot/A0A2R8MB22 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/9483:SMIM5 ^@ http://purl.uniprot.org/uniprot/F7IM97 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:RAB9A ^@ http://purl.uniprot.org/uniprot/F6QQX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||phagosome membrane http://togogenome.org/gene/9483:SLC46A3 ^@ http://purl.uniprot.org/uniprot/F7H3K0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:CRYBB1 ^@ http://purl.uniprot.org/uniprot/F7GNU3 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9483:RLN2 ^@ http://purl.uniprot.org/uniprot/A0A2R8MSJ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.|||Secreted http://togogenome.org/gene/9483:PTCD3 ^@ http://purl.uniprot.org/uniprot/A0A8I3W350|||http://purl.uniprot.org/uniprot/F7DQG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS39 family.|||Mitochondrion http://togogenome.org/gene/9483:HNMT ^@ http://purl.uniprot.org/uniprot/A0A2R8MUE3 ^@ Function|||Subunit ^@ Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.|||Monomer. http://togogenome.org/gene/9483:IAH1 ^@ http://purl.uniprot.org/uniprot/F7GM17 ^@ Function|||Similarity ^@ Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.|||Probable lipase. http://togogenome.org/gene/9483:MESD ^@ http://purl.uniprot.org/uniprot/A0A2R8N0D9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MESD family.|||Endoplasmic reticulum http://togogenome.org/gene/9483:TRAF3 ^@ http://purl.uniprot.org/uniprot/F7IEC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/9483:ASB13 ^@ http://purl.uniprot.org/uniprot/U3ENW7 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9483:TAS2R4 ^@ http://purl.uniprot.org/uniprot/A0A1C9ZVV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane|||cilium membrane http://togogenome.org/gene/9483:TRIM41 ^@ http://purl.uniprot.org/uniprot/F7HTG7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRIM/RBCC family.|||Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:LOC100409895 ^@ http://purl.uniprot.org/uniprot/A0A5F4VUR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:TDP2 ^@ http://purl.uniprot.org/uniprot/F7HX74 ^@ Subcellular Location Annotation ^@ PML body http://togogenome.org/gene/9483:IRAK1BP1 ^@ http://purl.uniprot.org/uniprot/U3CNT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRAK1BP1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:PSD3 ^@ http://purl.uniprot.org/uniprot/A0A2R8MM89|||http://purl.uniprot.org/uniprot/A0A2R8P673|||http://purl.uniprot.org/uniprot/F7I2E7 ^@ Subcellular Location Annotation ^@ Membrane|||ruffle membrane http://togogenome.org/gene/9483:LRRC8C ^@ http://purl.uniprot.org/uniprot/F7GH23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:EIF2D ^@ http://purl.uniprot.org/uniprot/F7IPX2 ^@ Similarity ^@ Belongs to the eIF2D family. http://togogenome.org/gene/9483:RRAGA ^@ http://purl.uniprot.org/uniprot/U3FLU1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/9483:CHST10 ^@ http://purl.uniprot.org/uniprot/F6WIW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:SDR9C7 ^@ http://purl.uniprot.org/uniprot/F6PH06 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9483:MON1B ^@ http://purl.uniprot.org/uniprot/F6VWD1 ^@ Function|||Similarity ^@ Belongs to the MON1/SAND family.|||Plays an important role in membrane trafficking through the secretory apparatus. http://togogenome.org/gene/9483:LOC100414342 ^@ http://purl.uniprot.org/uniprot/F7I4U5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9483:WDFY1 ^@ http://purl.uniprot.org/uniprot/F7IMJ5 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9483:FKTN ^@ http://purl.uniprot.org/uniprot/A0A8I3W7G7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LicD transferase family.|||Golgi apparatus membrane http://togogenome.org/gene/9483:LEP ^@ http://purl.uniprot.org/uniprot/F7HGW1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the leptin family.|||Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways. May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells. Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 wich promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38. In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses. Increases CD4(+)CD25(-) T-cell proliferation and reduces autophagy during TCR (T-cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation.|||Secreted http://togogenome.org/gene/9483:LOC100412918 ^@ http://purl.uniprot.org/uniprot/A0A2R8ME03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom7 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9483:CHST9 ^@ http://purl.uniprot.org/uniprot/F7CJ65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:ORAI2 ^@ http://purl.uniprot.org/uniprot/U3FX23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Orai family.|||Membrane http://togogenome.org/gene/9483:MRPL40 ^@ http://purl.uniprot.org/uniprot/U3C174 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL40 family.|||Mitochondrion http://togogenome.org/gene/9483:PARP8 ^@ http://purl.uniprot.org/uniprot/U3CCZ6 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9483:METTL8 ^@ http://purl.uniprot.org/uniprot/F6W273 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/9483:P4HB ^@ http://purl.uniprot.org/uniprot/A0A8I3WKE0|||http://purl.uniprot.org/uniprot/U3EQL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9483:ATP6V0B ^@ http://purl.uniprot.org/uniprot/A0A8J8XU00|||http://purl.uniprot.org/uniprot/U3E3T0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9483:LOC100409993 ^@ http://purl.uniprot.org/uniprot/A0A8I3X651 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9483:ABCB7 ^@ http://purl.uniprot.org/uniprot/U3DYY2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.|||Membrane|||Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and NHERF1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through NHERF1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation. http://togogenome.org/gene/9483:CPA3 ^@ http://purl.uniprot.org/uniprot/F7HXH8 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9483:GABRR2 ^@ http://purl.uniprot.org/uniprot/A0A5F4WEQ9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9483:STOM ^@ http://purl.uniprot.org/uniprot/U3ER07 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/9483:OST4 ^@ http://purl.uniprot.org/uniprot/A0A2R8M6K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:SENP5 ^@ http://purl.uniprot.org/uniprot/F6UAA3|||http://purl.uniprot.org/uniprot/U3CRE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C48 family.|||nucleolus http://togogenome.org/gene/9483:NTAQ1 ^@ http://purl.uniprot.org/uniprot/U3B6I9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NTAQ1 family.|||Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.|||Monomer. http://togogenome.org/gene/9483:CCDC124 ^@ http://purl.uniprot.org/uniprot/F6URD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC124 family.|||Midbody http://togogenome.org/gene/9483:ACE2 ^@ http://purl.uniprot.org/uniprot/F7CNJ6 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M2 family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Cytoplasm|||Membrane|||Secreted|||cilium http://togogenome.org/gene/9483:PPP3CC ^@ http://purl.uniprot.org/uniprot/F6ZW86 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-2B subfamily. http://togogenome.org/gene/9483:HOXD13 ^@ http://purl.uniprot.org/uniprot/F7GPP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9483:TIMM23B ^@ http://purl.uniprot.org/uniprot/F7GXV5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9483:PDIK1L ^@ http://purl.uniprot.org/uniprot/F7I2V6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:POLR1H ^@ http://purl.uniprot.org/uniprot/F7G0Q7|||http://purl.uniprot.org/uniprot/X5IYV1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.|||nucleolus http://togogenome.org/gene/9483:MTMR6 ^@ http://purl.uniprot.org/uniprot/F7GSA1 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9483:LOC103792189 ^@ http://purl.uniprot.org/uniprot/A0A2R8MUI6 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9483:RSPRY1 ^@ http://purl.uniprot.org/uniprot/F6YSF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Nucleus http://togogenome.org/gene/9483:SDR16C5 ^@ http://purl.uniprot.org/uniprot/F6W9K3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9483:GABARAP ^@ http://purl.uniprot.org/uniprot/F7ANW4 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9483:TMEM47 ^@ http://purl.uniprot.org/uniprot/U3E0Q9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/9483:CDIP1 ^@ http://purl.uniprot.org/uniprot/U3E6P6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/9483:TWSG1 ^@ http://purl.uniprot.org/uniprot/U3FRT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the twisted gastrulation protein family.|||Secreted http://togogenome.org/gene/9483:CDK6 ^@ http://purl.uniprot.org/uniprot/F6YF92 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:SLC8A1 ^@ http://purl.uniprot.org/uniprot/F7HA33|||http://purl.uniprot.org/uniprot/U3BXM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:TOMM40L ^@ http://purl.uniprot.org/uniprot/F7F8X7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom40 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9483:DYNLT5 ^@ http://purl.uniprot.org/uniprot/F7I7T4 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/9483:MPHOSPH8 ^@ http://purl.uniprot.org/uniprot/F7IFM1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:HRH4 ^@ http://purl.uniprot.org/uniprot/F7IT43 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9483:CYP11B1 ^@ http://purl.uniprot.org/uniprot/A0A8I3W6Q9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9483:NAP1L2 ^@ http://purl.uniprot.org/uniprot/U3D3N0 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9483:PREB ^@ http://purl.uniprot.org/uniprot/U3EK40|||http://purl.uniprot.org/uniprot/U3FN18 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat SEC12 family.|||Endoplasmic reticulum membrane|||Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.|||Interacts with SAR1B (GDP-bound form). Interacts with MIA2; recruits PREB to endoplasmic reticulum exit sites.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription. http://togogenome.org/gene/9483:TTC39C ^@ http://purl.uniprot.org/uniprot/F6TC78 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/9483:ARAF ^@ http://purl.uniprot.org/uniprot/A0A5K1VS71|||http://purl.uniprot.org/uniprot/U3ETY3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. http://togogenome.org/gene/9483:IPO11 ^@ http://purl.uniprot.org/uniprot/A0A8I3W4U3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:NOP10 ^@ http://purl.uniprot.org/uniprot/F7GPI1 ^@ Similarity ^@ Belongs to the NOP10 family. http://togogenome.org/gene/9483:ANXA10 ^@ http://purl.uniprot.org/uniprot/F7IS42 ^@ Similarity ^@ Belongs to the annexin family. http://togogenome.org/gene/9483:STX12 ^@ http://purl.uniprot.org/uniprot/U3EHM2 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9483:SERINC4 ^@ http://purl.uniprot.org/uniprot/F6XD46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9483:RIPK2 ^@ http://purl.uniprot.org/uniprot/A0A8I3WJB6|||http://purl.uniprot.org/uniprot/F7HDX4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.|||Cytoplasm|||Found in a signaling complex consisting of at least ARHGEF2, NOD2 and RIPK2.|||Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses. Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments. http://togogenome.org/gene/9483:HDHD3 ^@ http://purl.uniprot.org/uniprot/F7DX60 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/9483:TMEM205 ^@ http://purl.uniprot.org/uniprot/F7IAE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM205 family.|||Membrane http://togogenome.org/gene/9483:ALDH3A1 ^@ http://purl.uniprot.org/uniprot/F6YGX5 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9483:IFI35 ^@ http://purl.uniprot.org/uniprot/U3EE92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NMI family.|||Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/9483:ATP5PO ^@ http://purl.uniprot.org/uniprot/B0VXH3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-162 decreases ATP production. Deacetylated by SIRT3 (By similarity).|||Belongs to the ATPase delta chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity).|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity).|||Mitochondrion|||Mitochondrion inner membrane http://togogenome.org/gene/9483:PRKG1 ^@ http://purl.uniprot.org/uniprot/A0A2R8P3E2|||http://purl.uniprot.org/uniprot/U3DWF4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily. http://togogenome.org/gene/9483:CYP17A1 ^@ http://purl.uniprot.org/uniprot/Q5IFI0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9483:LARP7 ^@ http://purl.uniprot.org/uniprot/A0A5K1U6J8|||http://purl.uniprot.org/uniprot/U3EBY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LARP7 family.|||nucleoplasm http://togogenome.org/gene/9483:ZIC1 ^@ http://purl.uniprot.org/uniprot/F7IQP6 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/9483:POLR3GL ^@ http://purl.uniprot.org/uniprot/F7EJW7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPC7 RNA polymerase subunit family.|||Component of the RNA polymerase III (Pol III) complex.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/9483:CHN1 ^@ http://purl.uniprot.org/uniprot/U3FJE7 ^@ Function ^@ GTPase-activating protein for p21-rac. http://togogenome.org/gene/9483:CNOT9 ^@ http://purl.uniprot.org/uniprot/U3DJB7|||http://purl.uniprot.org/uniprot/U3E3W4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT9 family.|||P-body http://togogenome.org/gene/9483:FAM174B ^@ http://purl.uniprot.org/uniprot/A0A8I3W409 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM174 family.|||Membrane http://togogenome.org/gene/9483:SLC29A3 ^@ http://purl.uniprot.org/uniprot/F6ZJ21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/9483:ZNF75D ^@ http://purl.uniprot.org/uniprot/F7III9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:NOSIP ^@ http://purl.uniprot.org/uniprot/F7HBU1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOSIP family.|||Cytoplasm|||Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.|||Nucleus http://togogenome.org/gene/9483:NR1I3 ^@ http://purl.uniprot.org/uniprot/A0A2R8NDY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9483:SPAST ^@ http://purl.uniprot.org/uniprot/A0A8I3WWX5|||http://purl.uniprot.org/uniprot/U3E3W7|||http://purl.uniprot.org/uniprot/U3ERW9 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex. Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex. Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling. Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing. Probably plays a role in axon growth and the formation of axonal branches.|||Allosteric enzyme with a cooperative mechanism; at least two neighbor subunits influence each other strongly in spastin hexamers. Microtubule binding promotes cooperative interactions among spastin subunits.|||Belongs to the AAA ATPase family. Spastin subfamily.|||Cytoplasm|||Endoplasmic reticulum|||Homohexamer. Mostly monomeric, but assembles into hexameric structure for short periods of time. Oligomerization seems to be a prerequisite for catalytic activity. Binding to ATP in a cleft between two adjacent subunits stabilizes the homohexameric form. Binds to microtubules at least in part via the alpha-tubulin and beta-tubulin tails. The hexamer adopts a ring conformation through which microtubules pass prior to being severed. Does not interact strongly with tubulin heterodimers. Interacts (via MIT domain) with CHMP1B; the interaction is direct. Interacts with SSNA1. Interacts with ATL1. Interacts with RTN1. Interacts with ZFYVE27. Interacts with REEP1. Interacts (via MIT domain) with IST1.|||Membrane|||Midbody|||Nucleus|||axon|||centrosome|||cytoskeleton|||perinuclear region|||spindle http://togogenome.org/gene/9483:LIPK ^@ http://purl.uniprot.org/uniprot/F7HHI7 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9483:STOML3 ^@ http://purl.uniprot.org/uniprot/U3E9Z8 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/9483:SLC16A6 ^@ http://purl.uniprot.org/uniprot/U3E6Q4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:SORD ^@ http://purl.uniprot.org/uniprot/U3FKU4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the zinc-containing alcohol dehydrogenase family.|||Binds 1 or 2 Zn(2+) ions per subunit.|||Homotetramer.|||Mitochondrion membrane|||Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility.|||flagellum http://togogenome.org/gene/9483:FBXL5 ^@ http://purl.uniprot.org/uniprot/U3ER22 ^@ Subcellular Location Annotation ^@ perinuclear region http://togogenome.org/gene/9483:MEFV ^@ http://purl.uniprot.org/uniprot/A0A8I3WT58 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRIM/RBCC family.|||Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:SYT16 ^@ http://purl.uniprot.org/uniprot/F7B0F6 ^@ Similarity ^@ Belongs to the synaptotagmin family. http://togogenome.org/gene/9483:LOC100407633 ^@ http://purl.uniprot.org/uniprot/F7IFS4 ^@ Similarity ^@ Belongs to the dihydrofolate reductase family. http://togogenome.org/gene/9483:HDAC5 ^@ http://purl.uniprot.org/uniprot/U3CRZ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD type 2 subfamily.|||Nucleus|||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. http://togogenome.org/gene/9483:PEX3 ^@ http://purl.uniprot.org/uniprot/U3EA46 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with PEX19.|||Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.|||Peroxisome membrane http://togogenome.org/gene/9483:POLR2B ^@ http://purl.uniprot.org/uniprot/U3EIW2 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/9483:CSTF3 ^@ http://purl.uniprot.org/uniprot/F7BUE9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:NNAT ^@ http://purl.uniprot.org/uniprot/A0A2R8NBJ7 ^@ Similarity ^@ Belongs to the neuronatin family. http://togogenome.org/gene/9483:PARD6B ^@ http://purl.uniprot.org/uniprot/F6RQ62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAR6 family.|||Cytoplasm|||tight junction http://togogenome.org/gene/9483:RPS29 ^@ http://purl.uniprot.org/uniprot/F7D3P5 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Component of the 40S small ribosomal subunit. http://togogenome.org/gene/9483:FARS2 ^@ http://purl.uniprot.org/uniprot/U3D2M7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Mitochondrion matrix http://togogenome.org/gene/9483:GGA3 ^@ http://purl.uniprot.org/uniprot/F7HBR1|||http://purl.uniprot.org/uniprot/F7HPW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GGA protein family.|||Early endosome membrane|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9483:LOC100406483 ^@ http://purl.uniprot.org/uniprot/U3CIR1 ^@ Similarity|||Subunit ^@ Belongs to the GST superfamily. Mu family.|||Homodimer. http://togogenome.org/gene/9483:CHRDL1 ^@ http://purl.uniprot.org/uniprot/F6ZC35|||http://purl.uniprot.org/uniprot/U3F7K0 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9483:TMOD2 ^@ http://purl.uniprot.org/uniprot/U3CC20 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9483:CPNE2 ^@ http://purl.uniprot.org/uniprot/U3FSA6 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9483:MOG ^@ http://purl.uniprot.org/uniprot/Q29ZQ1|||http://purl.uniprot.org/uniprot/U3E6A3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Do not confuse myelin-oligodendrocyte glycoprotein (MOG) with oligodendrocyte-myelin glycoprotein (OMG).|||Homodimer.|||Membrane|||Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion (By similarity).|||Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion. http://togogenome.org/gene/9483:C11H11orf68 ^@ http://purl.uniprot.org/uniprot/A0A8I3WIN4 ^@ Similarity ^@ Belongs to the UPF0696 family. http://togogenome.org/gene/9483:LOC100399119 ^@ http://purl.uniprot.org/uniprot/A0A2R8MLV9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:NOB1 ^@ http://purl.uniprot.org/uniprot/U3DVR1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOB1 family.|||May play a role in mRNA degradation.|||Nucleus http://togogenome.org/gene/9483:DPH3 ^@ http://purl.uniprot.org/uniprot/F7GJH5 ^@ Similarity ^@ Belongs to the DPH3 family. http://togogenome.org/gene/9483:EME1 ^@ http://purl.uniprot.org/uniprot/U3DSD4 ^@ Similarity ^@ Belongs to the EME1/MMS4 family. http://togogenome.org/gene/9483:KIF13B ^@ http://purl.uniprot.org/uniprot/A0A8I3WB80|||http://purl.uniprot.org/uniprot/A0A8I3WUR5 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9483:HSD17B13 ^@ http://purl.uniprot.org/uniprot/F7IKL6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9483:MRPS30 ^@ http://purl.uniprot.org/uniprot/F7INF2 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9483:OPA3 ^@ http://purl.uniprot.org/uniprot/F7IF97|||http://purl.uniprot.org/uniprot/F7IFA3 ^@ Function|||Similarity ^@ Belongs to the OPA3 family.|||May play some role in mitochondrial processes. http://togogenome.org/gene/9483:RPS27A ^@ http://purl.uniprot.org/uniprot/A0A2R8MVQ0 ^@ Similarity ^@ In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.|||In the N-terminal section; belongs to the ubiquitin family. http://togogenome.org/gene/9483:FAP ^@ http://purl.uniprot.org/uniprot/F7I3L2 ^@ Subcellular Location Annotation ^@ Cell membrane|||invadopodium membrane|||lamellipodium membrane http://togogenome.org/gene/9483:PKIG ^@ http://purl.uniprot.org/uniprot/A0A8I3WJV0 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/9483:ABCG5 ^@ http://purl.uniprot.org/uniprot/A0A8I4A477 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/9483:TSPO ^@ http://purl.uniprot.org/uniprot/F7G6Z3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TspO/BZRP family.|||Membrane http://togogenome.org/gene/9483:ROPN1L ^@ http://purl.uniprot.org/uniprot/F6WPX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ropporin family.|||flagellum http://togogenome.org/gene/9483:KXD1 ^@ http://purl.uniprot.org/uniprot/F6XQT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KXD1 family.|||Lysosome membrane http://togogenome.org/gene/9483:MTIF2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YR64 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/9483:C16H8orf33 ^@ http://purl.uniprot.org/uniprot/U3DG87 ^@ Similarity ^@ Belongs to the UPF0488 family. http://togogenome.org/gene/9483:DCLK2 ^@ http://purl.uniprot.org/uniprot/F6YPI4|||http://purl.uniprot.org/uniprot/U3DBF3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9483:XRCC4 ^@ http://purl.uniprot.org/uniprot/E5FGK5|||http://purl.uniprot.org/uniprot/F7D0M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XRCC4-XLF family. XRCC4 subfamily.|||Nucleus http://togogenome.org/gene/9483:FOXB1 ^@ http://purl.uniprot.org/uniprot/F7DU19 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:URGCP ^@ http://purl.uniprot.org/uniprot/A0A8I3X7B4|||http://purl.uniprot.org/uniprot/F7IDX1|||http://purl.uniprot.org/uniprot/F7IGB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.|||Nucleus http://togogenome.org/gene/9483:EIF2A ^@ http://purl.uniprot.org/uniprot/U3FTB8 ^@ Function|||Similarity ^@ Belongs to the WD repeat EIF2A family.|||Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. http://togogenome.org/gene/9483:ZHX3 ^@ http://purl.uniprot.org/uniprot/F6QSD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZHX family.|||Nucleus http://togogenome.org/gene/9483:ALAS1 ^@ http://purl.uniprot.org/uniprot/U3DYR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:PIK3R3 ^@ http://purl.uniprot.org/uniprot/F7EAE6 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/9483:LZTS2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XFH7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LZTS2 family.|||Cytoplasm|||Interacts with KATNB1. Also interacts with CTNNB1, gamma-tubulin and KIF23.|||Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.|||centrosome http://togogenome.org/gene/9483:THAP1 ^@ http://purl.uniprot.org/uniprot/F7F581 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the THAP1 family.|||DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.|||Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.|||nucleoplasm http://togogenome.org/gene/9483:GBGT1 ^@ http://purl.uniprot.org/uniprot/F6R2J3|||http://purl.uniprot.org/uniprot/F7H240 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 6 family.|||Binds 1 Mn(2+) ion per subunit.|||Membrane http://togogenome.org/gene/9483:TSEN15 ^@ http://purl.uniprot.org/uniprot/F7GWP4 ^@ Similarity ^@ Belongs to the SEN15 family. http://togogenome.org/gene/9483:AP3S1 ^@ http://purl.uniprot.org/uniprot/F7A561|||http://purl.uniprot.org/uniprot/F7A577 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Membrane|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. http://togogenome.org/gene/9483:SLC25A29 ^@ http://purl.uniprot.org/uniprot/F7HYS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9483:RHBDF2 ^@ http://purl.uniprot.org/uniprot/U3BRJ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S54 family.|||Endoplasmic reticulum membrane|||Membrane|||Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. http://togogenome.org/gene/9483:EBAG9 ^@ http://purl.uniprot.org/uniprot/U3DJE5 ^@ Function|||Subcellular Location Annotation ^@ Golgi apparatus membrane|||May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. http://togogenome.org/gene/9483:MAP3K5 ^@ http://purl.uniprot.org/uniprot/U3DSH8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/9483:GSR ^@ http://purl.uniprot.org/uniprot/A2TIL1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Cytoplasm|||Homodimer; disulfide-linked.|||Maintains high levels of reduced glutathione in the cytosol.|||Mitochondrion http://togogenome.org/gene/9483:LOC100406511 ^@ http://purl.uniprot.org/uniprot/A0A8I3WG68 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9483:BORA ^@ http://purl.uniprot.org/uniprot/F7F1A6|||http://purl.uniprot.org/uniprot/F7F1B6 ^@ Similarity ^@ Belongs to the BORA family. http://togogenome.org/gene/9483:RANBP10 ^@ http://purl.uniprot.org/uniprot/F6WWM1|||http://purl.uniprot.org/uniprot/U3DAX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RANBP9/10 family.|||Belongs to the TRIM/RBCC family.|||Nucleus http://togogenome.org/gene/9483:HDC ^@ http://purl.uniprot.org/uniprot/F7HZT5 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9483:MFSD3 ^@ http://purl.uniprot.org/uniprot/F7G427 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:PDPK1 ^@ http://purl.uniprot.org/uniprot/U3FJT0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily. http://togogenome.org/gene/9483:TRMU ^@ http://purl.uniprot.org/uniprot/F7D8I5 ^@ Function|||Similarity ^@ Belongs to the MnmA/TRMU family.|||Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base. http://togogenome.org/gene/9483:OR52I2 ^@ http://purl.uniprot.org/uniprot/F7HA79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:ATL2 ^@ http://purl.uniprot.org/uniprot/U3F853|||http://purl.uniprot.org/uniprot/U3FVA3 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9483:RORB ^@ http://purl.uniprot.org/uniprot/F7IE87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9483:CCBE1 ^@ http://purl.uniprot.org/uniprot/F7GK04 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:DCAF10 ^@ http://purl.uniprot.org/uniprot/F6PGQ0 ^@ Function|||Similarity ^@ Belongs to the WD repeat DCAF10 family.|||May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. http://togogenome.org/gene/9483:ELOVL5 ^@ http://purl.uniprot.org/uniprot/U3BWP0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL5 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Membrane|||dendrite http://togogenome.org/gene/9483:LOC100386984 ^@ http://purl.uniprot.org/uniprot/F7FHB4 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/9483:SNX25 ^@ http://purl.uniprot.org/uniprot/U3FLC2 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9483:LOC100411055 ^@ http://purl.uniprot.org/uniprot/A0A5F4VXM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. ICAM family.|||Membrane http://togogenome.org/gene/9483:TLN1 ^@ http://purl.uniprot.org/uniprot/U3D5Z3 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9483:KLHL15 ^@ http://purl.uniprot.org/uniprot/F7I5N2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:HOXD12 ^@ http://purl.uniprot.org/uniprot/A0A8I3WEK2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:SLC35E4 ^@ http://purl.uniprot.org/uniprot/U3ETL4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:TRPC4 ^@ http://purl.uniprot.org/uniprot/A0A5K1VJC0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:CBX3 ^@ http://purl.uniprot.org/uniprot/U3E4T3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:SGMS1 ^@ http://purl.uniprot.org/uniprot/A0A2R8MTY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/9483:NAB1 ^@ http://purl.uniprot.org/uniprot/F7IAX5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAB family.|||Homomultimers may associate with EGR1 bound to DNA.|||Nucleus http://togogenome.org/gene/9483:CWC15 ^@ http://purl.uniprot.org/uniprot/F6PQC3 ^@ Similarity ^@ Belongs to the CWC15 family. http://togogenome.org/gene/9483:ABT1 ^@ http://purl.uniprot.org/uniprot/U3ASY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESF2/ABP1 family.|||nucleolus http://togogenome.org/gene/9483:EXOC4 ^@ http://purl.uniprot.org/uniprot/U3F757 ^@ Function|||Similarity ^@ Belongs to the SEC8 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/9483:LOC100387215 ^@ http://purl.uniprot.org/uniprot/U3AXV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Membrane http://togogenome.org/gene/9483:PRRC1 ^@ http://purl.uniprot.org/uniprot/F7GSG9|||http://purl.uniprot.org/uniprot/U3EXL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRRC1 family.|||Golgi apparatus http://togogenome.org/gene/9483:PIGC ^@ http://purl.uniprot.org/uniprot/F7HL53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGC family.|||Membrane http://togogenome.org/gene/9483:PDE6C ^@ http://purl.uniprot.org/uniprot/F6V1P7 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9483:OGFOD1 ^@ http://purl.uniprot.org/uniprot/U3C724 ^@ Similarity ^@ Belongs to the TPA1 family. http://togogenome.org/gene/9483:TAS2R40 ^@ http://purl.uniprot.org/uniprot/F7I729 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9483:POLG ^@ http://purl.uniprot.org/uniprot/F7IMR4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DNA polymerase type-A family.|||Heterotrimer composed of a catalytic subunit and a homodimer of accessory subunits.|||Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA.|||mitochondrion nucleoid http://togogenome.org/gene/9483:FSCN3 ^@ http://purl.uniprot.org/uniprot/B0VXF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fascin family.|||cytoskeleton http://togogenome.org/gene/9483:ANXA4 ^@ http://purl.uniprot.org/uniprot/U3DQF6 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||Zymogen granule membrane http://togogenome.org/gene/9483:NSDHL ^@ http://purl.uniprot.org/uniprot/U3D149 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9483:ERLIN1 ^@ http://purl.uniprot.org/uniprot/F7GL48 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the band 7/mec-2 family.|||Endoplasmic reticulum membrane|||Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.|||Membrane http://togogenome.org/gene/9483:SLC16A4 ^@ http://purl.uniprot.org/uniprot/U3EYR4|||http://purl.uniprot.org/uniprot/U3FXK0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:N6AMT1 ^@ http://purl.uniprot.org/uniprot/F7GZW1|||http://purl.uniprot.org/uniprot/F7HFC3 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal PrmC-related family. http://togogenome.org/gene/9483:CPNE3 ^@ http://purl.uniprot.org/uniprot/F7FA36 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9483:MINDY3 ^@ http://purl.uniprot.org/uniprot/A0A8I3X8F9|||http://purl.uniprot.org/uniprot/U3EUJ4 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM188 subfamily.|||Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. http://togogenome.org/gene/9483:GGT7 ^@ http://purl.uniprot.org/uniprot/U3DER9|||http://purl.uniprot.org/uniprot/U3DHK9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyltransferase family.|||Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.|||Membrane http://togogenome.org/gene/9483:PHC1 ^@ http://purl.uniprot.org/uniprot/A0A8I3W0S8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:AP3B2 ^@ http://purl.uniprot.org/uniprot/U3C4P7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes large subunit family.|||Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9483:CCDC86 ^@ http://purl.uniprot.org/uniprot/F6WVK6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:GALNT14 ^@ http://purl.uniprot.org/uniprot/U3FMG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:CSNK1A1 ^@ http://purl.uniprot.org/uniprot/F7HFK8|||http://purl.uniprot.org/uniprot/U3CG48|||http://purl.uniprot.org/uniprot/U3E5N8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:TMPRSS11F ^@ http://purl.uniprot.org/uniprot/F7DJ92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Membrane http://togogenome.org/gene/9483:CIAO1 ^@ http://purl.uniprot.org/uniprot/F6WFZ4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the WD repeat CIA1 family.|||Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.|||Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. http://togogenome.org/gene/9483:MCTS1 ^@ http://purl.uniprot.org/uniprot/F7GTQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCTS1 family.|||Cytoplasm http://togogenome.org/gene/9483:PMVK ^@ http://purl.uniprot.org/uniprot/F7IA91 ^@ Subcellular Location Annotation ^@ cytosol http://togogenome.org/gene/9483:REXO2 ^@ http://purl.uniprot.org/uniprot/U3DGZ4 ^@ Similarity ^@ Belongs to the oligoribonuclease family. http://togogenome.org/gene/9483:PTGES2 ^@ http://purl.uniprot.org/uniprot/F6XZ70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GST superfamily.|||Membrane http://togogenome.org/gene/9483:RPAP1 ^@ http://purl.uniprot.org/uniprot/U3BMA0 ^@ Similarity ^@ Belongs to the RPAP1 family. http://togogenome.org/gene/9483:SLC39A2 ^@ http://purl.uniprot.org/uniprot/F7I9X8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:RTN4 ^@ http://purl.uniprot.org/uniprot/U3FV09|||http://purl.uniprot.org/uniprot/U3FYH1 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:PDCD10 ^@ http://purl.uniprot.org/uniprot/F7I396 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDCD10 family.|||Cell membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:HOXB2 ^@ http://purl.uniprot.org/uniprot/F6XPS8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:HSD17B4 ^@ http://purl.uniprot.org/uniprot/U3EKB5 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/9483:PRMT3 ^@ http://purl.uniprot.org/uniprot/U3DAF5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:IDE ^@ http://purl.uniprot.org/uniprot/F7GU26 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/9483:LOC100409289 ^@ http://purl.uniprot.org/uniprot/A0A8I3ZZM3 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/9483:LOC100896043 ^@ http://purl.uniprot.org/uniprot/F7D3P5 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Component of the 40S small ribosomal subunit. http://togogenome.org/gene/9483:TIMM21 ^@ http://purl.uniprot.org/uniprot/F7IC46 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM21 family.|||Component of the TIM23 complex.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion membrane|||Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes. http://togogenome.org/gene/9483:MSRA ^@ http://purl.uniprot.org/uniprot/U3E1A6 ^@ Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family. http://togogenome.org/gene/9483:ZNF397 ^@ http://purl.uniprot.org/uniprot/A0A2R8P252|||http://purl.uniprot.org/uniprot/F7EAJ4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:GRK5 ^@ http://purl.uniprot.org/uniprot/U3C8T5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9483:KCNK1 ^@ http://purl.uniprot.org/uniprot/F6U0J3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Cell membrane|||Cytoplasmic vesicle|||Endosome|||Membrane|||Perikaryon|||Recycling endosome|||Synaptic cell membrane|||Vesicle|||dendrite http://togogenome.org/gene/9483:PPP2R5A ^@ http://purl.uniprot.org/uniprot/F7HW73 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9483:STN1 ^@ http://purl.uniprot.org/uniprot/F6SF17 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the STN1 family.|||Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.|||Component of the CST complex.|||Nucleus|||telomere http://togogenome.org/gene/9483:NAMPT ^@ http://purl.uniprot.org/uniprot/F7IR89 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAPRTase family.|||Cytoplasm|||Homodimer.|||Nucleus|||Secreted http://togogenome.org/gene/9483:SUGT1 ^@ http://purl.uniprot.org/uniprot/F7HGA2 ^@ Similarity ^@ Belongs to the SGT1 family. http://togogenome.org/gene/9483:ENTR1 ^@ http://purl.uniprot.org/uniprot/F7IM48 ^@ Similarity ^@ Belongs to the ENTR1 family. http://togogenome.org/gene/9483:PLSCR4 ^@ http://purl.uniprot.org/uniprot/U3DVJ1 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/9483:SLC46A1 ^@ http://purl.uniprot.org/uniprot/A0A5F4WHR3|||http://purl.uniprot.org/uniprot/F7IQD7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:LUC7L3 ^@ http://purl.uniprot.org/uniprot/A0A8I3W9U7|||http://purl.uniprot.org/uniprot/A0A8I3ZZ24|||http://purl.uniprot.org/uniprot/F7EI82 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/9483:PURG ^@ http://purl.uniprot.org/uniprot/U3DI37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PUR DNA-binding protein family.|||Nucleus http://togogenome.org/gene/9483:CLIC2 ^@ http://purl.uniprot.org/uniprot/U3DGX6 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/9483:FGF10 ^@ http://purl.uniprot.org/uniprot/A0A2R8M3J4 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9483:LOC100395188 ^@ http://purl.uniprot.org/uniprot/U3C8S8 ^@ Similarity ^@ Belongs to the COX20 family. http://togogenome.org/gene/9483:HTR6 ^@ http://purl.uniprot.org/uniprot/A0A5F4VZZ9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9483:CTLA4 ^@ http://purl.uniprot.org/uniprot/A0A2R8MRX8|||http://purl.uniprot.org/uniprot/C7EPD5|||http://purl.uniprot.org/uniprot/F7BDI2 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.|||Membrane http://togogenome.org/gene/9483:SIX6 ^@ http://purl.uniprot.org/uniprot/F7IFQ4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:PUS1 ^@ http://purl.uniprot.org/uniprot/F7EPT1 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/9483:HLX ^@ http://purl.uniprot.org/uniprot/F7IQA7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:DMTF1 ^@ http://purl.uniprot.org/uniprot/F7DF90 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:RGS9BP ^@ http://purl.uniprot.org/uniprot/A0A8I3X174 ^@ Similarity ^@ Belongs to the RGS7BP/RGS9BP family. http://togogenome.org/gene/9483:GPR25 ^@ http://purl.uniprot.org/uniprot/A0A5F4W8I4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9483:PUS10 ^@ http://purl.uniprot.org/uniprot/F7H2E3 ^@ Similarity ^@ Belongs to the pseudouridine synthase Pus10 family. http://togogenome.org/gene/9483:STEAP3 ^@ http://purl.uniprot.org/uniprot/A0A2R8MLD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9483:CER1 ^@ http://purl.uniprot.org/uniprot/F7HU74 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9483:BPGM ^@ http://purl.uniprot.org/uniprot/F7IFM9 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/9483:LOC100409051 ^@ http://purl.uniprot.org/uniprot/A0A8I3WHX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:BCAT2 ^@ http://purl.uniprot.org/uniprot/F7H895 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9483:NME5 ^@ http://purl.uniprot.org/uniprot/F7I8N9 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9483:AOC1 ^@ http://purl.uniprot.org/uniprot/F7CDQ6 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the copper/topaquinone oxidase family.|||Contains 1 topaquinone per subunit.|||Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. http://togogenome.org/gene/9483:BLVRA ^@ http://purl.uniprot.org/uniprot/U3ER63 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily.|||Monomer.|||Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.|||cytosol http://togogenome.org/gene/9483:MYLK ^@ http://purl.uniprot.org/uniprot/F7HQU3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. http://togogenome.org/gene/9483:SZRD1 ^@ http://purl.uniprot.org/uniprot/F7GHV9|||http://purl.uniprot.org/uniprot/F7GPU8 ^@ Similarity ^@ Belongs to the SZRD1 family. http://togogenome.org/gene/9483:DLD ^@ http://purl.uniprot.org/uniprot/U3DXC0 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond.|||acrosome|||flagellum http://togogenome.org/gene/9483:RAB29 ^@ http://purl.uniprot.org/uniprot/F7E162|||http://purl.uniprot.org/uniprot/U3F4Y5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/9483:SLC35E1 ^@ http://purl.uniprot.org/uniprot/F7BG87 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:CDR2 ^@ http://purl.uniprot.org/uniprot/U3DR45 ^@ Similarity ^@ Belongs to the CDR2 family. http://togogenome.org/gene/9483:CLDND2 ^@ http://purl.uniprot.org/uniprot/A0A8I3W6Q1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/9483:DPY19L3 ^@ http://purl.uniprot.org/uniprot/A0A2R8MVF7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dpy-19 family.|||Membrane|||Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. http://togogenome.org/gene/9483:LYZ ^@ http://purl.uniprot.org/uniprot/P79158|||http://purl.uniprot.org/uniprot/U3FDD0 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the glycosyl hydrolase 22 family.|||Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.|||Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.|||Monomer. http://togogenome.org/gene/9483:SLC35F1 ^@ http://purl.uniprot.org/uniprot/U3F1T2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/9483:WNT7B ^@ http://purl.uniprot.org/uniprot/U3BHR4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9483:CXCR2 ^@ http://purl.uniprot.org/uniprot/A0A8I3XF38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:YIPF6 ^@ http://purl.uniprot.org/uniprot/U3FLF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:BRPF1 ^@ http://purl.uniprot.org/uniprot/F7HVR4|||http://purl.uniprot.org/uniprot/U3DCL6|||http://purl.uniprot.org/uniprot/U3E149 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:FBXO34 ^@ http://purl.uniprot.org/uniprot/U3CLM7 ^@ Function ^@ Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. http://togogenome.org/gene/9483:LYPLA1 ^@ http://purl.uniprot.org/uniprot/F6R2S9 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/9483:SUGP2 ^@ http://purl.uniprot.org/uniprot/F6SZK4|||http://purl.uniprot.org/uniprot/U3DDJ7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:CYBRD1 ^@ http://purl.uniprot.org/uniprot/F7B047 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:LOC100396184 ^@ http://purl.uniprot.org/uniprot/A0A2R8NFC7 ^@ Similarity ^@ Belongs to the pro/parathymosin family. http://togogenome.org/gene/9483:TAF5 ^@ http://purl.uniprot.org/uniprot/F6SS06 ^@ Similarity ^@ Belongs to the WD repeat TAF5 family. http://togogenome.org/gene/9483:SAP30 ^@ http://purl.uniprot.org/uniprot/F7H7Z7 ^@ Similarity ^@ Belongs to the SAP30 family. http://togogenome.org/gene/9483:PSMD9 ^@ http://purl.uniprot.org/uniprot/F7HWG2 ^@ Similarity ^@ Belongs to the proteasome subunit p27 family. http://togogenome.org/gene/9483:PHLDA2 ^@ http://purl.uniprot.org/uniprot/A0A5F4W193 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:UHRF2 ^@ http://purl.uniprot.org/uniprot/A0A8I3WGN2|||http://purl.uniprot.org/uniprot/A0A8I3WHD7 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications.|||Nucleus|||The YDG domain mediates the interaction with histone H3.|||The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3). http://togogenome.org/gene/9483:NDUFB8 ^@ http://purl.uniprot.org/uniprot/F7HY80 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB8 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:LOC100401839 ^@ http://purl.uniprot.org/uniprot/F7G6P0 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9483:LOC100392421 ^@ http://purl.uniprot.org/uniprot/F7HWD4 ^@ Similarity ^@ Belongs to the SPIN/STSY family. http://togogenome.org/gene/9483:VTA1 ^@ http://purl.uniprot.org/uniprot/F7I3Z5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTA1 family.|||Cytoplasm|||Endosome membrane|||Membrane http://togogenome.org/gene/9483:GPBP1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YDL2|||http://purl.uniprot.org/uniprot/U3BEI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vasculin family.|||Nucleus http://togogenome.org/gene/9483:RPL35 ^@ http://purl.uniprot.org/uniprot/F7FP32 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/9483:CD4 ^@ http://purl.uniprot.org/uniprot/Q8HZT8 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9483:RPL22L1 ^@ http://purl.uniprot.org/uniprot/F7HZN0|||http://purl.uniprot.org/uniprot/U3D7B9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL22 family. http://togogenome.org/gene/9483:PAQR4 ^@ http://purl.uniprot.org/uniprot/F6XFB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9483:MMP14 ^@ http://purl.uniprot.org/uniprot/F7DBK0 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||Cytoplasm|||Melanosome http://togogenome.org/gene/9483:GNA11 ^@ http://purl.uniprot.org/uniprot/U3EPK0 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/9483:TMEM233 ^@ http://purl.uniprot.org/uniprot/F7BMF7 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9483:DACT3 ^@ http://purl.uniprot.org/uniprot/F6PHE1 ^@ Similarity ^@ Belongs to the dapper family. http://togogenome.org/gene/9483:CYSLTR2 ^@ http://purl.uniprot.org/uniprot/A0A8I4A2X1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9483:PCNX1 ^@ http://purl.uniprot.org/uniprot/U3F808 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pecanex family.|||Membrane http://togogenome.org/gene/9483:RIN1 ^@ http://purl.uniprot.org/uniprot/A0A8I3WU98 ^@ Similarity ^@ Belongs to the RIN (Ras interaction/interference) family. http://togogenome.org/gene/9483:DAZL ^@ http://purl.uniprot.org/uniprot/Q9BGN8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the RRM DAZ family.|||Cytoplasm|||Homodimer and heterodimer. Forms a heterodimer with DAZ. Interacts with BOLL, DAZAP1 and DAZAP2. Interacts with PUM2 Multiple DAZL RRMs can bind to a single RNA containing multiple GUU triplets (By similarity).|||Nucleus|||RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity).|||Testis specific.|||The DAZ domain mediates the interaction with DAZAP1 and DAZAP2. http://togogenome.org/gene/9483:PPP5C ^@ http://purl.uniprot.org/uniprot/F7AU33 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily. http://togogenome.org/gene/9483:SLC18A3 ^@ http://purl.uniprot.org/uniprot/F7E6H9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:SMAGP ^@ http://purl.uniprot.org/uniprot/A0A8I3WVC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMAGP family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/9483:TYMS ^@ http://purl.uniprot.org/uniprot/F7GTE7 ^@ Similarity ^@ Belongs to the thymidylate synthase family. http://togogenome.org/gene/9483:PPP1R1B ^@ http://purl.uniprot.org/uniprot/A5X4B2 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 1 family. http://togogenome.org/gene/9483:MMP2 ^@ http://purl.uniprot.org/uniprot/U3BX42 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||extracellular matrix http://togogenome.org/gene/9483:ACYP1 ^@ http://purl.uniprot.org/uniprot/F7IL81 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/9483:ZFPL1 ^@ http://purl.uniprot.org/uniprot/F7C4Y3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ZFPL1 family.|||Interacts with GOLGA2/GM130.|||Membrane|||Required for cis-Golgi integrity and efficient ER to Golgi transport.|||The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.|||cis-Golgi network membrane http://togogenome.org/gene/9483:CA2 ^@ http://purl.uniprot.org/uniprot/U3EKN4 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9483:FARSB ^@ http://purl.uniprot.org/uniprot/F7HYR5 ^@ Similarity ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily. http://togogenome.org/gene/9483:UTP14A ^@ http://purl.uniprot.org/uniprot/A0A5F4VYY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP14 family.|||nucleolus http://togogenome.org/gene/9483:CDC73 ^@ http://purl.uniprot.org/uniprot/F7DT12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC73 family.|||Nucleus http://togogenome.org/gene/9483:CMPK1 ^@ http://purl.uniprot.org/uniprot/A0A5F4WEC7|||http://purl.uniprot.org/uniprot/U3DRU9 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.|||Binds 1 Mg(2+) ion per monomer.|||Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Monomer.|||Nucleus http://togogenome.org/gene/9483:ELOVL4 ^@ http://purl.uniprot.org/uniprot/F7HHW6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ELO family. ELOVL4 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.|||Endoplasmic reticulum membrane|||Membrane|||Oligomer.|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9483:ECHDC2 ^@ http://purl.uniprot.org/uniprot/F6Z954 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9483:OR2T2 ^@ http://purl.uniprot.org/uniprot/F7GB81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:LOC100396164 ^@ http://purl.uniprot.org/uniprot/F6RV10 ^@ Similarity ^@ Belongs to the CFAP97 family. http://togogenome.org/gene/9483:NXF3 ^@ http://purl.uniprot.org/uniprot/F7G9J9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:PPARGC1A ^@ http://purl.uniprot.org/uniprot/F7EFK3|||http://purl.uniprot.org/uniprot/F7I1G0 ^@ Subcellular Location Annotation ^@ PML body http://togogenome.org/gene/9483:CHMP1B ^@ http://purl.uniprot.org/uniprot/U3FTU8 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9483:SYNCRIP ^@ http://purl.uniprot.org/uniprot/F7A621|||http://purl.uniprot.org/uniprot/U3ECQ6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:EIF4E2 ^@ http://purl.uniprot.org/uniprot/F6YZJ2|||http://purl.uniprot.org/uniprot/F6YZR4|||http://purl.uniprot.org/uniprot/F7F0B4 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/9483:SERP1 ^@ http://purl.uniprot.org/uniprot/A0A8I3WJU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAMP4 family.|||Endoplasmic reticulum membrane|||May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.|||Membrane http://togogenome.org/gene/9483:SLC25A5 ^@ http://purl.uniprot.org/uniprot/U3F849 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/9483:THBS1 ^@ http://purl.uniprot.org/uniprot/F7IIH4 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:GAL3ST3 ^@ http://purl.uniprot.org/uniprot/F7G7D8 ^@ Similarity ^@ Belongs to the galactose-3-O-sulfotransferase family. http://togogenome.org/gene/9483:DEFB119 ^@ http://purl.uniprot.org/uniprot/F7IIL6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9483:NKX3-2 ^@ http://purl.uniprot.org/uniprot/A0A2R8MAF7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:DSG1 ^@ http://purl.uniprot.org/uniprot/F7IT33 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.|||Membrane|||desmosome http://togogenome.org/gene/9483:SATB1 ^@ http://purl.uniprot.org/uniprot/U3E5K5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/9483:IST1 ^@ http://purl.uniprot.org/uniprot/F7HET2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IST1 family.|||Cytoplasmic vesicle|||Nucleus envelope http://togogenome.org/gene/9483:ELMO3 ^@ http://purl.uniprot.org/uniprot/F6V8Y7 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. http://togogenome.org/gene/9483:NTRK3 ^@ http://purl.uniprot.org/uniprot/F7E6X3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Membrane http://togogenome.org/gene/9483:PANX3 ^@ http://purl.uniprot.org/uniprot/A0A5F4W531 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Structural component of the gap junctions and the hemichannels.|||gap junction http://togogenome.org/gene/9483:LAGE3 ^@ http://purl.uniprot.org/uniprot/F6XD09 ^@ Similarity ^@ Belongs to the CTAG/PCC1 family. http://togogenome.org/gene/9483:CHCHD6 ^@ http://purl.uniprot.org/uniprot/A0A2R8N699|||http://purl.uniprot.org/uniprot/F7HBA6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic25 subfamily.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9483:IYD ^@ http://purl.uniprot.org/uniprot/A0A8I3W347 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9483:LMX1A ^@ http://purl.uniprot.org/uniprot/A0A8I4A505 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:SH3GL2 ^@ http://purl.uniprot.org/uniprot/F7IB79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Membrane http://togogenome.org/gene/9483:TOB1 ^@ http://purl.uniprot.org/uniprot/F7FBT1 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9483:LUC7L2 ^@ http://purl.uniprot.org/uniprot/F6YZF7|||http://purl.uniprot.org/uniprot/F7EI42 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/9483:TNFAIP6 ^@ http://purl.uniprot.org/uniprot/F7IEL1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:FAM229B ^@ http://purl.uniprot.org/uniprot/F7IJT2 ^@ Similarity ^@ Belongs to the FAM229 family. http://togogenome.org/gene/9483:LOC100411827 ^@ http://purl.uniprot.org/uniprot/A0A2R8P9R1 ^@ Similarity|||Subcellular Location Annotation ^@ Cytoplasm|||In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.|||In the N-terminal section; belongs to the ubiquitin family.|||Nucleus http://togogenome.org/gene/9483:MB21D2 ^@ http://purl.uniprot.org/uniprot/F7HXU5 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9483:MAP3K12 ^@ http://purl.uniprot.org/uniprot/U3AP94|||http://purl.uniprot.org/uniprot/U3B721 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||May be an activator of the JNK/SAPK pathway. http://togogenome.org/gene/9483:RHBDD3 ^@ http://purl.uniprot.org/uniprot/F6VHH2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:FAM135B ^@ http://purl.uniprot.org/uniprot/U3EHE2 ^@ Similarity ^@ Belongs to the FAM135 family. http://togogenome.org/gene/9483:LOC100396945 ^@ http://purl.uniprot.org/uniprot/A0A8I3WKW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:ZNF532 ^@ http://purl.uniprot.org/uniprot/U3DCG2 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9483:OR51A4 ^@ http://purl.uniprot.org/uniprot/B0VXA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:TPT1 ^@ http://purl.uniprot.org/uniprot/F7GC12 ^@ Similarity ^@ Belongs to the TCTP family. http://togogenome.org/gene/9483:LOC100399201 ^@ http://purl.uniprot.org/uniprot/F7H1H0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/9483:PTPN4 ^@ http://purl.uniprot.org/uniprot/A0A5F4VQQ4|||http://purl.uniprot.org/uniprot/F7GY33 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||May act at junctions between the membrane and the cytoskeleton.|||cytoskeleton http://togogenome.org/gene/9483:SUMO1 ^@ http://purl.uniprot.org/uniprot/F7HZB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin family. SUMO subfamily.|||Nucleus http://togogenome.org/gene/9483:ERC1 ^@ http://purl.uniprot.org/uniprot/A0A2R8MF14|||http://purl.uniprot.org/uniprot/A0A5K1UVS9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:CNRIP1 ^@ http://purl.uniprot.org/uniprot/F7F7F9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CNRIP family.|||Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.|||Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. http://togogenome.org/gene/9483:CPSF2 ^@ http://purl.uniprot.org/uniprot/A0A8I3WIR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.|||Nucleus http://togogenome.org/gene/9483:DSG2 ^@ http://purl.uniprot.org/uniprot/U3CJP8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||desmosome http://togogenome.org/gene/9483:GUCY2D ^@ http://purl.uniprot.org/uniprot/F7EAY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane|||Photoreceptor outer segment membrane http://togogenome.org/gene/9483:MET ^@ http://purl.uniprot.org/uniprot/A0A8I3WZT4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:MIP ^@ http://purl.uniprot.org/uniprot/F7EEJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9483:IGFBP6 ^@ http://purl.uniprot.org/uniprot/F6PGT7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9483:PPP1R1C ^@ http://purl.uniprot.org/uniprot/A0A5F4WBD2 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 1 family. http://togogenome.org/gene/9483:GRB2 ^@ http://purl.uniprot.org/uniprot/F7IQR6 ^@ Subcellular Location Annotation ^@ Endosome|||Golgi apparatus|||Nucleus http://togogenome.org/gene/9483:RPS10 ^@ http://purl.uniprot.org/uniprot/A0A2R8N9P5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS10 family. http://togogenome.org/gene/9483:PSMB6 ^@ http://purl.uniprot.org/uniprot/F6ZUS5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:TRADD ^@ http://purl.uniprot.org/uniprot/F6WBD6 ^@ Subcellular Location Annotation ^@ Nucleus|||cytoskeleton http://togogenome.org/gene/9483:THRB ^@ http://purl.uniprot.org/uniprot/F6S9P7|||http://purl.uniprot.org/uniprot/U3F706 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9483:AVPR1A ^@ http://purl.uniprot.org/uniprot/U3BDH7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane|||Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. http://togogenome.org/gene/9483:ADIPOR2 ^@ http://purl.uniprot.org/uniprot/F6UC87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9483:STEAP4 ^@ http://purl.uniprot.org/uniprot/F7IQW3|||http://purl.uniprot.org/uniprot/U3CVX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9483:CRYBB3 ^@ http://purl.uniprot.org/uniprot/F7IHF5 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9483:SYNPR ^@ http://purl.uniprot.org/uniprot/A0A2R8MVD5|||http://purl.uniprot.org/uniprot/U3EN47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/9483:REEP2 ^@ http://purl.uniprot.org/uniprot/U3DC83|||http://purl.uniprot.org/uniprot/U3EAG6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9483:LOC100392947 ^@ http://purl.uniprot.org/uniprot/F7IQC0 ^@ Similarity ^@ Belongs to the CFAP144 family. http://togogenome.org/gene/9483:CEP70 ^@ http://purl.uniprot.org/uniprot/F7ISR7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.|||Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.|||centrosome http://togogenome.org/gene/9483:FUT11 ^@ http://purl.uniprot.org/uniprot/F7ISY3|||http://purl.uniprot.org/uniprot/U3EP82 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Membrane|||Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. http://togogenome.org/gene/9483:EGR3 ^@ http://purl.uniprot.org/uniprot/U3CAC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/9483:MRPL2 ^@ http://purl.uniprot.org/uniprot/F7H807 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/9483:MVD ^@ http://purl.uniprot.org/uniprot/U3B9E3 ^@ Function|||Similarity ^@ Belongs to the diphosphomevalonate decarboxylase family.|||Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis. http://togogenome.org/gene/9483:LIN7C ^@ http://purl.uniprot.org/uniprot/F7DG56 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the lin-7 family.|||Cell membrane|||Lateral cell membrane|||Membrane|||Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.|||Postsynaptic density membrane|||tight junction http://togogenome.org/gene/9483:EID2B ^@ http://purl.uniprot.org/uniprot/F7IT55 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:DLX3 ^@ http://purl.uniprot.org/uniprot/F6REF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus http://togogenome.org/gene/9483:TCP11L2 ^@ http://purl.uniprot.org/uniprot/A0A2R8MUW6 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/9483:MCM8 ^@ http://purl.uniprot.org/uniprot/F7GG92|||http://purl.uniprot.org/uniprot/F7GG99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Chromosome|||Nucleus http://togogenome.org/gene/9483:GPATCH11 ^@ http://purl.uniprot.org/uniprot/A0A8J8XKX4 ^@ Similarity ^@ Belongs to the GPATCH11 family. http://togogenome.org/gene/9483:RALYL ^@ http://purl.uniprot.org/uniprot/U3FCB5 ^@ Similarity ^@ Belongs to the RRM HNRPC family. RALY subfamily. http://togogenome.org/gene/9483:ADGRF2 ^@ http://purl.uniprot.org/uniprot/A0A5F4WC74 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:POLR2I ^@ http://purl.uniprot.org/uniprot/F7IC64 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/9483:SPSB1 ^@ http://purl.uniprot.org/uniprot/F6SE99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPSB family.|||Belongs to the TRIM/RBCC family.|||Nucleus http://togogenome.org/gene/9483:PPM1B ^@ http://purl.uniprot.org/uniprot/F7CEC1|||http://purl.uniprot.org/uniprot/U3E6M8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PP2C family.|||Membrane|||cytosol http://togogenome.org/gene/9483:SLC7A9 ^@ http://purl.uniprot.org/uniprot/F6X914 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:SLF2 ^@ http://purl.uniprot.org/uniprot/U3D0T8 ^@ Similarity ^@ Belongs to the FAM178 family. http://togogenome.org/gene/9483:MCM2 ^@ http://purl.uniprot.org/uniprot/U3APR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Chromosome|||Nucleus http://togogenome.org/gene/9483:ADK ^@ http://purl.uniprot.org/uniprot/F6W4L8|||http://purl.uniprot.org/uniprot/U3E4R2|||http://purl.uniprot.org/uniprot/U3FJH2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.|||Belongs to the carbohydrate kinase PfkB family.|||Binds 3 Mg(2+) ions per subunit.|||Monomer.|||Nucleus http://togogenome.org/gene/9483:HDAC1 ^@ http://purl.uniprot.org/uniprot/F7CCQ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins.|||Nucleus http://togogenome.org/gene/9483:GLO1 ^@ http://purl.uniprot.org/uniprot/U3CM58 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the glyoxalase I family.|||Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.|||Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. http://togogenome.org/gene/9483:NAPRT ^@ http://purl.uniprot.org/uniprot/U3F8H4 ^@ Function|||PTM|||Similarity ^@ Belongs to the NAPRTase family.|||Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.|||Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. http://togogenome.org/gene/9483:IMPA1 ^@ http://purl.uniprot.org/uniprot/F6SDQ5 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/9483:RNF7 ^@ http://purl.uniprot.org/uniprot/F7EDD9 ^@ Similarity ^@ Belongs to the RING-box family. http://togogenome.org/gene/9483:RUVBL1 ^@ http://purl.uniprot.org/uniprot/U3C0J1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RuvB family.|||Dynein axonemal particle|||Nucleus|||Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. http://togogenome.org/gene/9483:SLC35F2 ^@ http://purl.uniprot.org/uniprot/A0A2R8P1H7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/9483:TBX22 ^@ http://purl.uniprot.org/uniprot/F7I0J1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9483:ECHS1 ^@ http://purl.uniprot.org/uniprot/U3BLA7 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9483:EIF3L ^@ http://purl.uniprot.org/uniprot/U3FPU4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit L family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RRN3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm http://togogenome.org/gene/9483:GGCX ^@ http://purl.uniprot.org/uniprot/F7GD44 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:LOC100398744 ^@ http://purl.uniprot.org/uniprot/A0A8I4A1P1 ^@ Similarity|||Subunit ^@ Belongs to the ENDOU family.|||Monomer. http://togogenome.org/gene/9483:DYNC2LI1 ^@ http://purl.uniprot.org/uniprot/F6SL64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light intermediate chain family.|||centrosome|||cilium|||cilium axoneme|||cilium basal body http://togogenome.org/gene/9483:TNFSF13 ^@ http://purl.uniprot.org/uniprot/A0A2R8MGF4|||http://purl.uniprot.org/uniprot/F7GHR8 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9483:ORMDL2 ^@ http://purl.uniprot.org/uniprot/F7IL07 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/9483:LOC100403687 ^@ http://purl.uniprot.org/uniprot/A0A8I3VZC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL51 family.|||Mitochondrion http://togogenome.org/gene/9483:FAM163B ^@ http://purl.uniprot.org/uniprot/F7DIS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM163 family.|||Membrane http://togogenome.org/gene/9483:UNC5CL ^@ http://purl.uniprot.org/uniprot/F6RK11 ^@ Similarity ^@ Belongs to the unc-5 family. http://togogenome.org/gene/9483:NMU ^@ http://purl.uniprot.org/uniprot/Q5YLW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NmU family.|||Secreted http://togogenome.org/gene/9483:ALDH1A1 ^@ http://purl.uniprot.org/uniprot/A0A8I3WAY2 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9483:PDGFD ^@ http://purl.uniprot.org/uniprot/U3EU18|||http://purl.uniprot.org/uniprot/U3FRK3 ^@ Caution|||Similarity ^@ Belongs to the PDGF/VEGF growth factor family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:CPB2 ^@ http://purl.uniprot.org/uniprot/F6Y124 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9483:POU5F1 ^@ http://purl.uniprot.org/uniprot/F6U7N9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/9483:FOXA3 ^@ http://purl.uniprot.org/uniprot/A0A8I3WHM5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:DOK1 ^@ http://purl.uniprot.org/uniprot/F7GS04 ^@ Similarity ^@ Belongs to the DOK family. Type A subfamily. http://togogenome.org/gene/9483:FAM168A ^@ http://purl.uniprot.org/uniprot/F7IEX3 ^@ Similarity ^@ Belongs to the FAM168 family. http://togogenome.org/gene/9483:SLC1A1 ^@ http://purl.uniprot.org/uniprot/F7H1G8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9483:ALG8 ^@ http://purl.uniprot.org/uniprot/F7FEU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG6/ALG8 glucosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:UBL3 ^@ http://purl.uniprot.org/uniprot/F6YU90 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9483:TFAP2C ^@ http://purl.uniprot.org/uniprot/U3D041 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/9483:PPARGC1B ^@ http://purl.uniprot.org/uniprot/U3BVQ2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:ELAC2 ^@ http://purl.uniprot.org/uniprot/U3FAR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase Z family.|||mitochondrion nucleoid http://togogenome.org/gene/9483:EBF1 ^@ http://purl.uniprot.org/uniprot/F7I410 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COE family.|||Nucleus http://togogenome.org/gene/9483:JAGN1 ^@ http://purl.uniprot.org/uniprot/F7HKL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the jagunal family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:ATP6V0A2 ^@ http://purl.uniprot.org/uniprot/F7IBX3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/9483:LOC100406802 ^@ http://purl.uniprot.org/uniprot/B0KWN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL18 family.|||Cytoplasm http://togogenome.org/gene/9483:CRY1 ^@ http://purl.uniprot.org/uniprot/U3F9C3 ^@ Cofactor|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/9483:TAF4B ^@ http://purl.uniprot.org/uniprot/A0A5F4WAK9|||http://purl.uniprot.org/uniprot/U3FQK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF4 family.|||Nucleus http://togogenome.org/gene/9483:HIBCH ^@ http://purl.uniprot.org/uniprot/U3C1G0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.|||Mitochondrion http://togogenome.org/gene/9483:KCNN2 ^@ http://purl.uniprot.org/uniprot/A0A2R8P946 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:INSL5 ^@ http://purl.uniprot.org/uniprot/A0A8I4A3G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/9483:AP3B1 ^@ http://purl.uniprot.org/uniprot/U3E1L9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes large subunit family.|||Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9483:CXCR6 ^@ http://purl.uniprot.org/uniprot/A0A5F4WCZ6 ^@ Function|||Similarity ^@ Belongs to the G-protein coupled receptor 1 family.|||Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1. http://togogenome.org/gene/9483:NAPEPLD ^@ http://purl.uniprot.org/uniprot/U3E0R8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAPE-PLD family.|||Binds 2 zinc divalent cations per subunit.|||Homodimer. Bile acids promote the assembly of inactive monomers into an active dimer and enable catalysis.|||Nucleus envelope http://togogenome.org/gene/9483:SLC17A3 ^@ http://purl.uniprot.org/uniprot/F7HHV4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:AGT ^@ http://purl.uniprot.org/uniprot/Q9TSZ0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Acts by binding to angiotensin receptors AGTR1 and AGTR2. Also binds the DEAR/FBXW7-AS1 receptor.|||Belongs to the serpin family.|||Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.|||In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin) (By similarity).|||Is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.|||Secreted|||Stimulates aldosterone release.|||The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin (By similarity). http://togogenome.org/gene/9483:ATP5F1A ^@ http://purl.uniprot.org/uniprot/U3EFQ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/9483:AK6 ^@ http://purl.uniprot.org/uniprot/F7I9S8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.|||Cajal body|||Monomer and homodimer. Interacts with COIL (via C-terminus).|||nucleoplasm http://togogenome.org/gene/9483:SLC37A3 ^@ http://purl.uniprot.org/uniprot/F6S3H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Membrane http://togogenome.org/gene/9483:OR8D4 ^@ http://purl.uniprot.org/uniprot/A0A5F4WEG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:ABCD2 ^@ http://purl.uniprot.org/uniprot/A0A8I3WI60|||http://purl.uniprot.org/uniprot/F6SKS4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.|||Membrane|||Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and NHERF1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through NHERF1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation. http://togogenome.org/gene/9483:EMC2 ^@ http://purl.uniprot.org/uniprot/A0A2R8PEZ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC2 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. http://togogenome.org/gene/9483:APIP ^@ http://purl.uniprot.org/uniprot/F7HHV2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aldolase class II family. Adducin subfamily.|||Belongs to the aldolase class II family. MtnB subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.|||Cytoplasm|||Homotetramer. Interacts with APAF1. May interact with CASP1. http://togogenome.org/gene/9483:GPRC5D ^@ http://purl.uniprot.org/uniprot/A0A2R8MZ45|||http://purl.uniprot.org/uniprot/A0A8I3VZ43 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9483:ACKR2 ^@ http://purl.uniprot.org/uniprot/A0A5F4WH17 ^@ Subcellular Location Annotation ^@ Cell membrane|||Early endosome|||Endosome|||Membrane http://togogenome.org/gene/9483:LOC100404083 ^@ http://purl.uniprot.org/uniprot/F7DXI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:DIP2B ^@ http://purl.uniprot.org/uniprot/F7H527|||http://purl.uniprot.org/uniprot/U3CSQ1 ^@ Similarity ^@ Belongs to the DIP2 family. http://togogenome.org/gene/9483:DIS3L2 ^@ http://purl.uniprot.org/uniprot/F7C0G6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.|||Belongs to the RNR ribonuclease family. DIS3L2 subfamily.|||Cytoplasm|||P-body|||Specifically recognizes and binds polyuridylated RNAs via 3 RNA-binding regions (named U-zone 1, U-zone 2 and U-zone 3) that form an open funnel on one face of the catalytic domain, allowing RNA to navigate a path to the active site. http://togogenome.org/gene/9483:UNC50 ^@ http://purl.uniprot.org/uniprot/U3FGA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-50 family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/9483:KIF12 ^@ http://purl.uniprot.org/uniprot/F6QG00 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9483:CDK5 ^@ http://purl.uniprot.org/uniprot/U3D7M9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:B3GAT2 ^@ http://purl.uniprot.org/uniprot/A0A5F4VXW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:LOC108589416 ^@ http://purl.uniprot.org/uniprot/B0VXF6 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9483:RPS19BP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8M2P1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AROS family.|||nucleolus http://togogenome.org/gene/9483:LOC100386651 ^@ http://purl.uniprot.org/uniprot/A0A5F4W5B8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9483:RPS12 ^@ http://purl.uniprot.org/uniprot/F7I360 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS12 family. http://togogenome.org/gene/9483:DERL3 ^@ http://purl.uniprot.org/uniprot/H9KWP3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Membrane http://togogenome.org/gene/9483:FTH1 ^@ http://purl.uniprot.org/uniprot/A0A2R8P242 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/9483:HMX2 ^@ http://purl.uniprot.org/uniprot/F7BVY3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:SHANK3 ^@ http://purl.uniprot.org/uniprot/B3Y6D6 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Postsynaptic density http://togogenome.org/gene/9483:ARL6IP5 ^@ http://purl.uniprot.org/uniprot/F7G0P2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/9483:MED27 ^@ http://purl.uniprot.org/uniprot/F6SYI8|||http://purl.uniprot.org/uniprot/F7H8C4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 27 family.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9483:ISCA2 ^@ http://purl.uniprot.org/uniprot/F7HKC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HesB/IscA family.|||Mitochondrion http://togogenome.org/gene/9483:ERN2 ^@ http://purl.uniprot.org/uniprot/F7I6Y8 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9483:AGPS ^@ http://purl.uniprot.org/uniprot/F7IJA4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FAD-binding oxidoreductase/transferase type 4 family.|||Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.|||Homodimer.|||Peroxisome http://togogenome.org/gene/9483:ARF4 ^@ http://purl.uniprot.org/uniprot/F6XY54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/9483:TNFSF11 ^@ http://purl.uniprot.org/uniprot/A0A0U5JXT4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Homotrimer.|||Membrane|||Secreted http://togogenome.org/gene/9483:NFYB ^@ http://purl.uniprot.org/uniprot/A0A2R8MBP1|||http://purl.uniprot.org/uniprot/F7ILD9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NFYB/HAP3 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.|||Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP. http://togogenome.org/gene/9483:GMNN ^@ http://purl.uniprot.org/uniprot/F7IB66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the geminin family.|||Nucleus http://togogenome.org/gene/9483:LOC100402218 ^@ http://purl.uniprot.org/uniprot/F6Y6J2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eS7 family.|||centrosome http://togogenome.org/gene/9483:CDH5 ^@ http://purl.uniprot.org/uniprot/A0A8J8XM80 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:PKN2 ^@ http://purl.uniprot.org/uniprot/F7AVM1|||http://purl.uniprot.org/uniprot/F7I3Y0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cleavage furrow|||Midbody|||Nucleus http://togogenome.org/gene/9483:EIF2B5 ^@ http://purl.uniprot.org/uniprot/U3B2E3 ^@ Similarity ^@ Belongs to the eIF-2B gamma/epsilon subunits family. http://togogenome.org/gene/9483:SYN3 ^@ http://purl.uniprot.org/uniprot/B0KWT3|||http://purl.uniprot.org/uniprot/U3D497 ^@ Similarity ^@ Belongs to the synapsin family. http://togogenome.org/gene/9483:SLC25A28 ^@ http://purl.uniprot.org/uniprot/A0A2R8M6A5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9483:ETV5 ^@ http://purl.uniprot.org/uniprot/F7FFP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9483:OR2AG2 ^@ http://purl.uniprot.org/uniprot/A0A5F4WKZ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:RUNDC3B ^@ http://purl.uniprot.org/uniprot/F7IN89|||http://purl.uniprot.org/uniprot/F7INB7|||http://purl.uniprot.org/uniprot/U3F9D9 ^@ Similarity|||Subunit ^@ Belongs to the RUNDC3 family.|||Interacts with RAP2A. http://togogenome.org/gene/9483:SERBP1 ^@ http://purl.uniprot.org/uniprot/A0A8I3W1Q6 ^@ Similarity ^@ Belongs to the SERBP1-HABP4 family. http://togogenome.org/gene/9483:TRIM42 ^@ http://purl.uniprot.org/uniprot/F7GYZ9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:CD19 ^@ http://purl.uniprot.org/uniprot/Q3LRP3 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (By similarity). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. Required for normal B cell differentiation and proliferation in response to antigen challenges. Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge (By similarity).|||Interacts with CR2/CD21. Part of a complex composed of CD19, CR2/CD21, CD81 and IFITM1/CD225 in the membrane of mature B-cells. Interacts directly with CD81 (via the second extracellular domain); this interaction is initiated early during biosynthesis in the ER/pre-Golgi compartments and is essential for trafficking and compartmentalization of CD19 receptor on the cell surface of activated B cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-350 and/or Tyr-380. Interacts with PLCG2 when phosphorylated on Tyr-411. Interacts with LYN. Interacts (when tyrosine phosphorylated) with the regulatory p85 subunit of phosphatidylinositol 3-kinase (PIK3R1 or PIK3R2).|||Membrane raft|||Phosphorylated on tyrosine following B-cell activation (By similarity). Phosphorylated on tyrosine residues by LYN (By similarity). Tyrosine residues are phosphorylated sequentially after activation of the B cell receptor. Phosphorylation of Tyr-533 is extremely rapid (By similarity). http://togogenome.org/gene/9483:STK17B ^@ http://purl.uniprot.org/uniprot/F7F3X9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:TRIM59 ^@ http://purl.uniprot.org/uniprot/F7ICN3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:ME1 ^@ http://purl.uniprot.org/uniprot/F7H233 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/9483:P4HA1 ^@ http://purl.uniprot.org/uniprot/F6ZW21|||http://purl.uniprot.org/uniprot/F7AWP3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9483:SLC25A14 ^@ http://purl.uniprot.org/uniprot/A0A2R8PEX3|||http://purl.uniprot.org/uniprot/A0A8I4A3E5|||http://purl.uniprot.org/uniprot/U3CVS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9483:IL1RL2 ^@ http://purl.uniprot.org/uniprot/F7DE27 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9483:SLC25A19 ^@ http://purl.uniprot.org/uniprot/F6XVW4|||http://purl.uniprot.org/uniprot/F7IGD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9483:LOC100405057 ^@ http://purl.uniprot.org/uniprot/A0A8I3W637 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:CAPN5 ^@ http://purl.uniprot.org/uniprot/U3D7U5 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9483:ZEB1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YDF4|||http://purl.uniprot.org/uniprot/F6TXI4|||http://purl.uniprot.org/uniprot/F7FN11 ^@ Similarity ^@ Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family. http://togogenome.org/gene/9483:PMF1 ^@ http://purl.uniprot.org/uniprot/F7AAA0 ^@ Subcellular Location Annotation ^@ Nucleus|||kinetochore http://togogenome.org/gene/9483:NIPAL1 ^@ http://purl.uniprot.org/uniprot/F7I3E2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9483:PLA2G1B ^@ http://purl.uniprot.org/uniprot/F7G478 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9483:KCNK17 ^@ http://purl.uniprot.org/uniprot/F7HWJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9483:TBX20 ^@ http://purl.uniprot.org/uniprot/F7HNF6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9483:TSPYL5 ^@ http://purl.uniprot.org/uniprot/F7FEB3 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9483:APOBEC3A ^@ http://purl.uniprot.org/uniprot/E9N3T9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||Cytoplasm|||DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA.|||Homodimer.|||Nucleus|||P-body|||The CMP/dCMP deaminase domain 1 mediates RNA binding, RNA-dependent oligomerization and virion incorporation whereas the CMP/dCMP deaminase domain 2 confers deoxycytidine deaminase activity and substrate sequence specificity. http://togogenome.org/gene/9483:ADAM23 ^@ http://purl.uniprot.org/uniprot/A0A5F4VY19|||http://purl.uniprot.org/uniprot/A0A5F4WMR5|||http://purl.uniprot.org/uniprot/F7HTE8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:SF1 ^@ http://purl.uniprot.org/uniprot/B0KWK3|||http://purl.uniprot.org/uniprot/U3BQS6|||http://purl.uniprot.org/uniprot/U3D370 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BBP/SF1 family.|||Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.|||Nucleus http://togogenome.org/gene/9483:RRM2B ^@ http://purl.uniprot.org/uniprot/F7I7U4 ^@ Similarity ^@ Belongs to the ribonucleoside diphosphate reductase small chain family. http://togogenome.org/gene/9483:MCUR1 ^@ http://purl.uniprot.org/uniprot/U3DZE1 ^@ Similarity ^@ Belongs to the CCDC90 family. http://togogenome.org/gene/9483:WNT3 ^@ http://purl.uniprot.org/uniprot/U3DRT3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9483:DEF8 ^@ http://purl.uniprot.org/uniprot/F6U1L1 ^@ Similarity ^@ Belongs to the DEF8 family. http://togogenome.org/gene/9483:EMP2 ^@ http://purl.uniprot.org/uniprot/F7I0U4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the PMP-22/EMP/MP20 family.|||Cell membrane|||Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion.|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Membrane raft|||Nucleus|||perinuclear region http://togogenome.org/gene/9483:GRWD1 ^@ http://purl.uniprot.org/uniprot/F6S353 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:MTFR1L ^@ http://purl.uniprot.org/uniprot/A0A5F4VRV1|||http://purl.uniprot.org/uniprot/F7HLK2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission. http://togogenome.org/gene/9483:BBS2 ^@ http://purl.uniprot.org/uniprot/F7IFY6 ^@ Subcellular Location Annotation ^@ centriolar satellite|||cilium membrane http://togogenome.org/gene/9483:RANBP6 ^@ http://purl.uniprot.org/uniprot/F6Q4X4 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9483:ELF2 ^@ http://purl.uniprot.org/uniprot/A0A5K1UTA1|||http://purl.uniprot.org/uniprot/F7ECT1|||http://purl.uniprot.org/uniprot/F7HVP3|||http://purl.uniprot.org/uniprot/F7HVP8|||http://purl.uniprot.org/uniprot/U3EME5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9483:KCNA6 ^@ http://purl.uniprot.org/uniprot/F7IIQ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:CCZ1 ^@ http://purl.uniprot.org/uniprot/U3BMT8 ^@ Similarity ^@ Belongs to the CCZ1 family. http://togogenome.org/gene/9483:LIPN ^@ http://purl.uniprot.org/uniprot/F7HHB8 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9483:PAX5 ^@ http://purl.uniprot.org/uniprot/F6T567 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with KDM5B.|||Nucleus|||Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs. http://togogenome.org/gene/9483:CLK4 ^@ http://purl.uniprot.org/uniprot/F7BCE4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9483:PYY ^@ http://purl.uniprot.org/uniprot/F6RMP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Secreted http://togogenome.org/gene/9483:THRSP ^@ http://purl.uniprot.org/uniprot/F7HQ62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPOT14 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:ELMO1 ^@ http://purl.uniprot.org/uniprot/F7IAL7 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. http://togogenome.org/gene/9483:PBX2 ^@ http://purl.uniprot.org/uniprot/U3BXR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/PBX homeobox family.|||Nucleus http://togogenome.org/gene/9483:FAXC ^@ http://purl.uniprot.org/uniprot/F7IL59 ^@ Similarity ^@ Belongs to the FAX family. http://togogenome.org/gene/9483:CDH20 ^@ http://purl.uniprot.org/uniprot/F7GWC6 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:NUDT7 ^@ http://purl.uniprot.org/uniprot/U3C9R2 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. PCD1 subfamily. http://togogenome.org/gene/9483:DIPK1B ^@ http://purl.uniprot.org/uniprot/F7EEN2 ^@ Similarity ^@ Belongs to the DIPK family. http://togogenome.org/gene/9483:DEFB118 ^@ http://purl.uniprot.org/uniprot/A0A2R8MX32 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9483:IZUMO1R ^@ http://purl.uniprot.org/uniprot/F6R036 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/9483:SPIRE1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YH72|||http://purl.uniprot.org/uniprot/U3D237|||http://purl.uniprot.org/uniprot/U3D3K3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the spire family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||cytoskeleton http://togogenome.org/gene/9483:NRP1 ^@ http://purl.uniprot.org/uniprot/A0A8I3VYW8|||http://purl.uniprot.org/uniprot/F6ZZA9 ^@ Caution|||Similarity ^@ Belongs to the neuropilin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:PRPF18 ^@ http://purl.uniprot.org/uniprot/U3EI83|||http://purl.uniprot.org/uniprot/U3FGS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP18 family.|||Nucleus speckle http://togogenome.org/gene/9483:SCGB1D1 ^@ http://purl.uniprot.org/uniprot/U3B870 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9483:AREG ^@ http://purl.uniprot.org/uniprot/U3D851 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:ERBB4 ^@ http://purl.uniprot.org/uniprot/F7HB76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/9483:SLC12A2 ^@ http://purl.uniprot.org/uniprot/F7EMU8|||http://purl.uniprot.org/uniprot/F7GC07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9483:SLC5A6 ^@ http://purl.uniprot.org/uniprot/F7I0A2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:SSRP1 ^@ http://purl.uniprot.org/uniprot/U3DZB6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SSRP1 family.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Nucleus http://togogenome.org/gene/9483:DNASE1L3 ^@ http://purl.uniprot.org/uniprot/A0A2R8M4Q4 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/9483:CANX ^@ http://purl.uniprot.org/uniprot/U3BBI3 ^@ Similarity ^@ Belongs to the calreticulin family. http://togogenome.org/gene/9483:SMARCB1 ^@ http://purl.uniprot.org/uniprot/U3DYG0|||http://purl.uniprot.org/uniprot/U3FFQ1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNF5 family.|||Component of the multiprotein chromatin-remodeling complexes SWI/SNF.|||Nucleus http://togogenome.org/gene/9483:SPP1 ^@ http://purl.uniprot.org/uniprot/U3EES2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the osteopontin family.|||Secreted http://togogenome.org/gene/9483:TMBIM1 ^@ http://purl.uniprot.org/uniprot/F7B0Y5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9483:PEX7 ^@ http://purl.uniprot.org/uniprot/A0A2R8MWM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat peroxin-7 family.|||Peroxisome matrix|||cytosol http://togogenome.org/gene/9483:ALDH6A1 ^@ http://purl.uniprot.org/uniprot/A0A2R8MKK4 ^@ Function|||Similarity ^@ Belongs to the aldehyde dehydrogenase family.|||Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA. http://togogenome.org/gene/9483:CDC5L ^@ http://purl.uniprot.org/uniprot/U3F3N0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEF1 family.|||Nucleus http://togogenome.org/gene/9483:DYNC1LI2 ^@ http://purl.uniprot.org/uniprot/U3E101 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.|||Belongs to the dynein light intermediate chain family.|||Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).|||cytoskeleton http://togogenome.org/gene/9483:FBXO25 ^@ http://purl.uniprot.org/uniprot/U3DQD2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:ANKS1B ^@ http://purl.uniprot.org/uniprot/F6YQ59 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:MRPS11 ^@ http://purl.uniprot.org/uniprot/U3C3V6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/9483:TAT ^@ http://purl.uniprot.org/uniprot/F7H4H2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. http://togogenome.org/gene/9483:LOC100411008 ^@ http://purl.uniprot.org/uniprot/F7HQH0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCRB/QCR7 family.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:SLC39A3 ^@ http://purl.uniprot.org/uniprot/A0A5F4W3D1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:GNG2 ^@ http://purl.uniprot.org/uniprot/F6PY28 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9483:FH ^@ http://purl.uniprot.org/uniprot/F7IP12 ^@ Function|||Similarity ^@ Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.|||Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. http://togogenome.org/gene/9483:EXOSC9 ^@ http://purl.uniprot.org/uniprot/F7IJD9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:PRDM14 ^@ http://purl.uniprot.org/uniprot/F7I6N5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:POFUT2 ^@ http://purl.uniprot.org/uniprot/U3DZM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 68 family.|||Endoplasmic reticulum http://togogenome.org/gene/9483:HDDC2 ^@ http://purl.uniprot.org/uniprot/U3EQI9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HDDC2 family.|||Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).|||Homodimer. http://togogenome.org/gene/9483:PPP1R11 ^@ http://purl.uniprot.org/uniprot/F7IDX6 ^@ Subunit ^@ Interacts with TLR2 and UBE2D2. http://togogenome.org/gene/9483:CDX1 ^@ http://purl.uniprot.org/uniprot/F7G6D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Caudal homeobox family.|||Nucleus http://togogenome.org/gene/9483:VBP1 ^@ http://purl.uniprot.org/uniprot/B0KWU9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit alpha family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/9483:MAST1 ^@ http://purl.uniprot.org/uniprot/F7IHG3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/9483:SIX5 ^@ http://purl.uniprot.org/uniprot/F7HN42 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:LOC100411687 ^@ http://purl.uniprot.org/uniprot/A0A8I3X3B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:MOSPD1 ^@ http://purl.uniprot.org/uniprot/A0A8I3WKV6|||http://purl.uniprot.org/uniprot/F6Z8Y6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:KCNJ13 ^@ http://purl.uniprot.org/uniprot/A0A5F4VRF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9483:SEC24B ^@ http://purl.uniprot.org/uniprot/U3F0Y9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9483:MZF1 ^@ http://purl.uniprot.org/uniprot/F7HIW5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:SMAD6 ^@ http://purl.uniprot.org/uniprot/U3B961 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:CYP51A1 ^@ http://purl.uniprot.org/uniprot/F7CSA0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9483:GKAP1 ^@ http://purl.uniprot.org/uniprot/U3CG34 ^@ Similarity ^@ Belongs to the GKAP1 family. http://togogenome.org/gene/9483:OR5L1 ^@ http://purl.uniprot.org/uniprot/F6Y0U0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:ACTRT3 ^@ http://purl.uniprot.org/uniprot/F7AKM4 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9483:P2RY11 ^@ http://purl.uniprot.org/uniprot/F7HZ21 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9483:CYP39A1 ^@ http://purl.uniprot.org/uniprot/F6X0Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9483:UBE4B ^@ http://purl.uniprot.org/uniprot/U3D326 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin conjugation factor E4 family.|||Cytoplasm|||The U-box domain is required for the ubiquitin protein ligase activity.|||Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. http://togogenome.org/gene/9483:HOXC11 ^@ http://purl.uniprot.org/uniprot/F7IAK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9483:TES ^@ http://purl.uniprot.org/uniprot/Q2QLG8|||http://purl.uniprot.org/uniprot/U3BT74 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prickle / espinas / testin family.|||Cytoplasm|||Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN (By similarity). Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer (By similarity).|||Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN (By similarity). Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer.|||Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor (By similarity).|||Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor.|||The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering interactions with ZYX.|||focal adhesion http://togogenome.org/gene/9483:LOC103787193 ^@ http://purl.uniprot.org/uniprot/F7I990 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9483:LOC100402578 ^@ http://purl.uniprot.org/uniprot/A0A8I4A3F6|||http://purl.uniprot.org/uniprot/U3D7T7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:CENPS ^@ http://purl.uniprot.org/uniprot/A0A2R8MH83 ^@ Similarity ^@ Belongs to the TAF9 family. CENP-S/MHF1 subfamily. http://togogenome.org/gene/9483:DUSP5 ^@ http://purl.uniprot.org/uniprot/F7I5X1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/9483:SLC25A3 ^@ http://purl.uniprot.org/uniprot/F7AN83|||http://purl.uniprot.org/uniprot/U3EHX0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Interacts with PPIF; the interaction is impaired by CsA.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9483:DSTN ^@ http://purl.uniprot.org/uniprot/F7I5M6 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. http://togogenome.org/gene/9483:IL4 ^@ http://purl.uniprot.org/uniprot/A4ZXA4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-4/IL-13 family.|||Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.|||Secreted http://togogenome.org/gene/9483:POLA2 ^@ http://purl.uniprot.org/uniprot/F6YPZ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.|||Belongs to the DNA polymerase alpha subunit B family.|||Nucleus http://togogenome.org/gene/9483:SNW1 ^@ http://purl.uniprot.org/uniprot/U3F5V0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNW family.|||Identified in the spliceosome C complex.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/9483:MYH7 ^@ http://purl.uniprot.org/uniprot/A0A8I3ZYV9 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9483:NME3 ^@ http://purl.uniprot.org/uniprot/F7FUB6 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9483:FLOT1 ^@ http://purl.uniprot.org/uniprot/U3FR84 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily.|||Cell membrane|||Endosome|||Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.|||May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.|||Membrane|||Membrane raft|||caveola http://togogenome.org/gene/9483:MAT2B ^@ http://purl.uniprot.org/uniprot/U3EFG8|||http://purl.uniprot.org/uniprot/U3EH64 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.|||Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.|||Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. http://togogenome.org/gene/9483:LOC100405623 ^@ http://purl.uniprot.org/uniprot/F7I0C8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the hcp beta-lactamase family.|||Mitochondrion intermembrane space|||Required for assembly of mitochondrial respiratory chain complexes. http://togogenome.org/gene/9483:MRPS27 ^@ http://purl.uniprot.org/uniprot/U3E956 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9483:NDUFAF2 ^@ http://purl.uniprot.org/uniprot/A0A8I3W4X9 ^@ Similarity ^@ Belongs to the complex I NDUFA12 subunit family. http://togogenome.org/gene/9483:CFAP418 ^@ http://purl.uniprot.org/uniprot/A0A2R8MZL3|||http://purl.uniprot.org/uniprot/F7I023 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in photoreceptor outer segment disk morphogenesis.|||Photoreceptor inner segment http://togogenome.org/gene/9483:SLC2A13 ^@ http://purl.uniprot.org/uniprot/A0A8J8YSG2 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/9483:ADAMTS19 ^@ http://purl.uniprot.org/uniprot/F7GX00 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9483:FUT8 ^@ http://purl.uniprot.org/uniprot/F7CXF2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 23 family.|||Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9483:COPS7B ^@ http://purl.uniprot.org/uniprot/F7AUQ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9483:SCN3B ^@ http://purl.uniprot.org/uniprot/F7I734 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.|||Membrane|||Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. http://togogenome.org/gene/9483:LIM2 ^@ http://purl.uniprot.org/uniprot/F7HZ88 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis. http://togogenome.org/gene/9483:IMPDH2 ^@ http://purl.uniprot.org/uniprot/U3BIW7|||http://purl.uniprot.org/uniprot/U3CQ93 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.|||Nucleus http://togogenome.org/gene/9483:B3GALT2 ^@ http://purl.uniprot.org/uniprot/F7DSY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9483:E2F6 ^@ http://purl.uniprot.org/uniprot/F6PNG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9483:PHOX2B ^@ http://purl.uniprot.org/uniprot/A0A2R8PD18 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:SFRP2 ^@ http://purl.uniprot.org/uniprot/U3CQ08 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:PPP1R12A ^@ http://purl.uniprot.org/uniprot/F7GX51|||http://purl.uniprot.org/uniprot/U3D7H7 ^@ Subcellular Location Annotation|||Subunit ^@ PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.|||stress fiber http://togogenome.org/gene/9483:API5 ^@ http://purl.uniprot.org/uniprot/A0A5K1VKE6|||http://purl.uniprot.org/uniprot/A0A8J8XXQ3 ^@ Similarity ^@ Belongs to the API5 family. http://togogenome.org/gene/9483:PFDN1 ^@ http://purl.uniprot.org/uniprot/F6WRG6 ^@ Function|||Similarity ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. http://togogenome.org/gene/9483:SLC25A51 ^@ http://purl.uniprot.org/uniprot/U3BCM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9483:NDUFA13 ^@ http://purl.uniprot.org/uniprot/A0A2R8P7Y2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I NDUFA13 subunit family.|||Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.|||Mitochondrion inner membrane http://togogenome.org/gene/9483:CHRNA10 ^@ http://purl.uniprot.org/uniprot/F6UH81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9483:POLR3C ^@ http://purl.uniprot.org/uniprot/F6Z6M4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/9483:MDM4 ^@ http://purl.uniprot.org/uniprot/F7IAD8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM2/MDM4 family.|||Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.|||Nucleus http://togogenome.org/gene/9483:LOC100404630 ^@ http://purl.uniprot.org/uniprot/A0A5F4VT85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:USP13 ^@ http://purl.uniprot.org/uniprot/U3CGS7 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9483:IGFBP4 ^@ http://purl.uniprot.org/uniprot/F6RPW3 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Binds IGF2 more than IGF1.|||IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9483:IL5RA ^@ http://purl.uniprot.org/uniprot/Q0PIT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 5 subfamily.|||Membrane http://togogenome.org/gene/9483:P2RY1 ^@ http://purl.uniprot.org/uniprot/F6VY42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9483:LECT2 ^@ http://purl.uniprot.org/uniprot/A0A2R8MQ44 ^@ Similarity ^@ Belongs to the LECT2/MIM-1 family. http://togogenome.org/gene/9483:AP3M1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XHJ4|||http://purl.uniprot.org/uniprot/U3FCJ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. http://togogenome.org/gene/9483:DMAP1 ^@ http://purl.uniprot.org/uniprot/F6PIU9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9483:AKAP5 ^@ http://purl.uniprot.org/uniprot/F7GXY9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:MMP9 ^@ http://purl.uniprot.org/uniprot/F7ICF8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||extracellular matrix http://togogenome.org/gene/9483:EGR1 ^@ http://purl.uniprot.org/uniprot/U3DKB1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Nucleus|||Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. http://togogenome.org/gene/9483:PEX12 ^@ http://purl.uniprot.org/uniprot/F7DEK1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pex2/pex10/pex12 family.|||Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9483:C7 ^@ http://purl.uniprot.org/uniprot/U3BDC8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9483:SLC25A36 ^@ http://purl.uniprot.org/uniprot/U3CF98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9483:C1QBP ^@ http://purl.uniprot.org/uniprot/F7HBC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAM33 family.|||Cell membrane http://togogenome.org/gene/9483:FHL5 ^@ http://purl.uniprot.org/uniprot/F7IJ11 ^@ Function|||Subcellular Location Annotation ^@ May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.|||Nucleus http://togogenome.org/gene/9483:NUDT4 ^@ http://purl.uniprot.org/uniprot/A0A8I3WGW0|||http://purl.uniprot.org/uniprot/U3DJD5 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DIPP subfamily. http://togogenome.org/gene/9483:DOLK ^@ http://purl.uniprot.org/uniprot/B0KWE4 ^@ Similarity ^@ Belongs to the polyprenol kinase family. http://togogenome.org/gene/9483:ZNF592 ^@ http://purl.uniprot.org/uniprot/U3AUS8 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9483:GLRB ^@ http://purl.uniprot.org/uniprot/F6RHN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane http://togogenome.org/gene/9483:DTNA ^@ http://purl.uniprot.org/uniprot/A0A2R8M781|||http://purl.uniprot.org/uniprot/A0A5K1VRY8|||http://purl.uniprot.org/uniprot/F7F217|||http://purl.uniprot.org/uniprot/U3E450|||http://purl.uniprot.org/uniprot/U3FJ85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dystrophin family. Dystrobrevin subfamily.|||Cytoplasm http://togogenome.org/gene/9483:LPIN1 ^@ http://purl.uniprot.org/uniprot/F7I1K8 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/9483:KIF19 ^@ http://purl.uniprot.org/uniprot/F7ELH6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9483:BRCC3 ^@ http://purl.uniprot.org/uniprot/U3C7H1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M67A family. BRCC36 subfamily.|||Binds 1 zinc ion per subunit.|||Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1 and BABAM2. Component of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Identified in a complex with SHMT2 and the other subunits of the BRISC complex. In the BRISC complex, interacts directly with ABRAXAS2. Identified in a complex with ABRAXAS2 and NUMA1. The BRISC complex interacts with the CSN complex. Component of the BRCA1/BRCA2 containing complex (BRCC), which also contains BRCA1, BRCA2, BARD1, BABAM2 and RAD51. BRCC is a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage. Interacts with BRCA1. Binds polyubiquitin. Interacts with PWWP2B. Interacts with HDAC1; this interaction is enhanced in the presence of PWWP2B.|||Cytoplasm|||Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.|||Nucleus|||spindle pole http://togogenome.org/gene/9483:CS ^@ http://purl.uniprot.org/uniprot/U3B7T8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the citrate synthase family.|||Homodimer.|||Mitochondrion matrix http://togogenome.org/gene/9483:LOC100402310 ^@ http://purl.uniprot.org/uniprot/F7CSR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9483:YWHAQ ^@ http://purl.uniprot.org/uniprot/F7DMM3 ^@ Function|||Similarity ^@ Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.|||Belongs to the 14-3-3 family. http://togogenome.org/gene/9483:SUPT16H ^@ http://purl.uniprot.org/uniprot/F7I120 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M24 family. SPT16 subfamily.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Component of the FACT complex.|||Nucleus http://togogenome.org/gene/9483:MINPP1 ^@ http://purl.uniprot.org/uniprot/F7HI35 ^@ Similarity ^@ Belongs to the histidine acid phosphatase family. MINPP1 subfamily. http://togogenome.org/gene/9483:C7H1orf174 ^@ http://purl.uniprot.org/uniprot/F7I356 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0688 family.|||Nucleus http://togogenome.org/gene/9483:SLC16A12 ^@ http://purl.uniprot.org/uniprot/A0A2R8MI35 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:TRPM8 ^@ http://purl.uniprot.org/uniprot/B0KW81 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:IPO9 ^@ http://purl.uniprot.org/uniprot/F6Y960|||http://purl.uniprot.org/uniprot/F6YAA9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9483:HOXA10 ^@ http://purl.uniprot.org/uniprot/B0VXK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9483:A2M ^@ http://purl.uniprot.org/uniprot/U3DSE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.|||Secreted http://togogenome.org/gene/9483:ANKRD13A ^@ http://purl.uniprot.org/uniprot/U3BR76 ^@ Function|||Subcellular Location Annotation ^@ Endosome|||Late endosome|||Membrane|||Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. http://togogenome.org/gene/9483:ASB17 ^@ http://purl.uniprot.org/uniprot/F6QB97 ^@ Function|||Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family.|||May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/9483:PTPA ^@ http://purl.uniprot.org/uniprot/B0KWF1|||http://purl.uniprot.org/uniprot/F6VY34 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTPA-type PPIase family.|||Cytoplasm|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9483:MIGA2 ^@ http://purl.uniprot.org/uniprot/B0KWE8 ^@ Similarity ^@ Belongs to the mitoguardin family. http://togogenome.org/gene/9483:WDFY2 ^@ http://purl.uniprot.org/uniprot/F6W2Z2 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9483:ZNF330 ^@ http://purl.uniprot.org/uniprot/F7IJI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOA36 family.|||centromere|||nucleolus http://togogenome.org/gene/9483:TNFRSF21 ^@ http://purl.uniprot.org/uniprot/F6QC41 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9483:UBE2L6 ^@ http://purl.uniprot.org/uniprot/A0A2R8N1M1 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9483:SGMS2 ^@ http://purl.uniprot.org/uniprot/F7I6J8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/9483:DGUOK ^@ http://purl.uniprot.org/uniprot/F7IMI0|||http://purl.uniprot.org/uniprot/U3D9U2 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/9483:GJB4 ^@ http://purl.uniprot.org/uniprot/F7CTW5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9483:LOC100406244 ^@ http://purl.uniprot.org/uniprot/F7ELW1 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9483:CACNA1D ^@ http://purl.uniprot.org/uniprot/F6VC98|||http://purl.uniprot.org/uniprot/F7I2J8|||http://purl.uniprot.org/uniprot/F7I2L9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily.|||Membrane|||Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. http://togogenome.org/gene/9483:HOXC9 ^@ http://purl.uniprot.org/uniprot/F7I5W0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/9483:CMTM5 ^@ http://purl.uniprot.org/uniprot/F7IGE3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9483:SPIN3 ^@ http://purl.uniprot.org/uniprot/F6PV54 ^@ Similarity ^@ Belongs to the SPIN/STSY family. http://togogenome.org/gene/9483:PGM1 ^@ http://purl.uniprot.org/uniprot/F6VQ06|||http://purl.uniprot.org/uniprot/U3DU43 ^@ Similarity ^@ Belongs to the phosphohexose mutase family.