http://togogenome.org/gene/9555:MRPL9 ^@ http://purl.uniprot.org/uniprot/A9X1A9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial ribosomal protein bL9 family.|||Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.|||Mitochondrion http://togogenome.org/gene/9555:PGK2 ^@ http://purl.uniprot.org/uniprot/A0A096MKN1 ^@ Similarity|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Monomer. http://togogenome.org/gene/9555:LRP10 ^@ http://purl.uniprot.org/uniprot/A0A096NSD1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:SERPINB7 ^@ http://purl.uniprot.org/uniprot/A9RA94 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9555:CCND2 ^@ http://purl.uniprot.org/uniprot/A0A8I5R9M5 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9555:RPS18 ^@ http://purl.uniprot.org/uniprot/A0A2I3MGM0 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Component of the small ribosomal subunit. http://togogenome.org/gene/9555:PAQR8 ^@ http://purl.uniprot.org/uniprot/A0A096N8P9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9555:MOB2 ^@ http://purl.uniprot.org/uniprot/A0A096NC20|||http://purl.uniprot.org/uniprot/A0A8I5N807 ^@ Similarity ^@ Belongs to the MOB1/phocein family. http://togogenome.org/gene/9555:ABCB8 ^@ http://purl.uniprot.org/uniprot/A0A2I3MGC9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:B3GAT2 ^@ http://purl.uniprot.org/uniprot/A0A096MP64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9555:SLC30A9 ^@ http://purl.uniprot.org/uniprot/A0A096N794 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Endoplasmic reticulum|||Membrane|||Mitochondrion membrane|||Nucleus http://togogenome.org/gene/9555:SMO ^@ http://purl.uniprot.org/uniprot/A0A096NUB7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||cilium http://togogenome.org/gene/9555:TMC5 ^@ http://purl.uniprot.org/uniprot/A0A096NWI5|||http://purl.uniprot.org/uniprot/A0A2I3LJH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMC family.|||Membrane http://togogenome.org/gene/9555:SVBP ^@ http://purl.uniprot.org/uniprot/A0A096NCU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SVBP family.|||Secreted|||cytoskeleton http://togogenome.org/gene/9555:RNF152 ^@ http://purl.uniprot.org/uniprot/A0A096NAU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNF152 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9555:POPDC3 ^@ http://purl.uniprot.org/uniprot/A0A096NDN5 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/9555:RORB ^@ http://purl.uniprot.org/uniprot/A0A8I5N0S2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9555:CRABP1 ^@ http://purl.uniprot.org/uniprot/A0A096NMV7 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9555:GNAZ ^@ http://purl.uniprot.org/uniprot/A0A096NRB0 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9555:GPT2 ^@ http://purl.uniprot.org/uniprot/A0A2I3M4W3 ^@ Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/9555:SNX14 ^@ http://purl.uniprot.org/uniprot/A0A096MXA3 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9555:ITGB1 ^@ http://purl.uniprot.org/uniprot/A0A096P446|||http://purl.uniprot.org/uniprot/A0A2I3MB35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:GNG3 ^@ http://purl.uniprot.org/uniprot/A0A8I5NPT8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9555:EGFL7 ^@ http://purl.uniprot.org/uniprot/A0A096NRS1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:FGFBP3 ^@ http://purl.uniprot.org/uniprot/A0A8I5RA06 ^@ Similarity ^@ Belongs to the fibroblast growth factor-binding protein family. http://togogenome.org/gene/9555:PDLIM1 ^@ http://purl.uniprot.org/uniprot/A0A096P5Q9 ^@ Subcellular Location Annotation ^@ Z line http://togogenome.org/gene/9555:MFSD6L ^@ http://purl.uniprot.org/uniprot/A0A8I5NAF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. MFSD6 family.|||Membrane http://togogenome.org/gene/9555:SLC5A2 ^@ http://purl.uniprot.org/uniprot/A0A096NHZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:SLC25A18 ^@ http://purl.uniprot.org/uniprot/A0A096NVY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9555:STMN2 ^@ http://purl.uniprot.org/uniprot/A0A2I3M6E5 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/9555:TMOD1 ^@ http://purl.uniprot.org/uniprot/A0A096P138 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9555:RUNX1 ^@ http://purl.uniprot.org/uniprot/A0A096NJ75|||http://purl.uniprot.org/uniprot/A0A2I3LQ88|||http://purl.uniprot.org/uniprot/A0A2I3MEK8 ^@ Function|||Subcellular Location Annotation ^@ Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.|||Nucleus http://togogenome.org/gene/9555:RRAGD ^@ http://purl.uniprot.org/uniprot/A0A096NY15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/9555:SLC17A7 ^@ http://purl.uniprot.org/uniprot/A0A0A0MUK5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:NRP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LTT8|||http://purl.uniprot.org/uniprot/A0A2I3M6A7 ^@ Caution|||Similarity ^@ Belongs to the neuropilin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:CUTC ^@ http://purl.uniprot.org/uniprot/A0A096P658 ^@ Similarity ^@ Belongs to the CutC family. http://togogenome.org/gene/9555:UBE2L3 ^@ http://purl.uniprot.org/uniprot/A0A096NS90 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9555:MSH6 ^@ http://purl.uniprot.org/uniprot/A0A096N5B7 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||Component of the post-replicative DNA mismatch repair system (MMR). http://togogenome.org/gene/9555:FUT4 ^@ http://purl.uniprot.org/uniprot/A0A8I5N7T3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9555:CNN3 ^@ http://purl.uniprot.org/uniprot/A0A096MP12 ^@ Function|||Similarity ^@ Belongs to the calponin family.|||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. http://togogenome.org/gene/9555:CUX1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LFS0|||http://purl.uniprot.org/uniprot/A0A2I3NDE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CASP family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9555:IPMK ^@ http://purl.uniprot.org/uniprot/A0A096P582 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9555:NRTN ^@ http://purl.uniprot.org/uniprot/A0A0A0MWA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family. GDNF subfamily.|||Secreted http://togogenome.org/gene/9555:MRPL41 ^@ http://purl.uniprot.org/uniprot/A0A8I5N2H7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL41 family.|||Mitochondrion http://togogenome.org/gene/9555:USP16 ^@ http://purl.uniprot.org/uniprot/A0A8I5RA67 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C19 family. USP16 subfamily.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Homotetramer.|||Nucleus|||Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. Phosphorylation by AURKB enhances the deubiquitinase activity.|||Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.|||The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin. http://togogenome.org/gene/9555:TM4SF19 ^@ http://purl.uniprot.org/uniprot/A0A096N397 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9555:OGT ^@ http://purl.uniprot.org/uniprot/A0A096N3Z8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.|||Cell projection|||Mitochondrion membrane http://togogenome.org/gene/9555:ANP32A ^@ http://purl.uniprot.org/uniprot/A0A096NMH2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANP32 family.|||Multifunctional protein that is involved in the regulation of many processes.|||Nucleus http://togogenome.org/gene/9555:PLIN1 ^@ http://purl.uniprot.org/uniprot/A0A096NN84 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/9555:RARB ^@ http://purl.uniprot.org/uniprot/A0A096NAQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9555:RABGGTA ^@ http://purl.uniprot.org/uniprot/A0A096NXB1 ^@ Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family.|||Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.|||Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. http://togogenome.org/gene/9555:PRKCE ^@ http://purl.uniprot.org/uniprot/A0A8I5NUI2 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration.|||Cell membrane|||Cytoplasm|||Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.|||Nucleus|||cytoskeleton|||perinuclear region http://togogenome.org/gene/9555:LOC103876537 ^@ http://purl.uniprot.org/uniprot/A0A096NHF4 ^@ Function|||Similarity ^@ Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis. http://togogenome.org/gene/9555:PPIL4 ^@ http://purl.uniprot.org/uniprot/A0A8I5NFS7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.|||Nucleus|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9555:TNFSF13 ^@ http://purl.uniprot.org/uniprot/A0A2I3MSE6|||http://purl.uniprot.org/uniprot/A0A2I3NAJ9 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9555:LOC108580406 ^@ http://purl.uniprot.org/uniprot/A0A8I5NZT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:EPHA3 ^@ http://purl.uniprot.org/uniprot/A0A096N0A8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:DCTN6 ^@ http://purl.uniprot.org/uniprot/A0A2I3LT94 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.|||Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.|||cytoskeleton http://togogenome.org/gene/9555:POP7 ^@ http://purl.uniprot.org/uniprot/A0A096N668 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone-like Alba family.|||Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA.|||Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.|||Cytoplasmic granule|||nucleolus http://togogenome.org/gene/9555:EIF5A ^@ http://purl.uniprot.org/uniprot/A0A096P2N9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:CDC123 ^@ http://purl.uniprot.org/uniprot/A0A096P3F7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC123 family.|||Cytoplasm|||Required for S phase entry of the cell cycle. http://togogenome.org/gene/9555:SPTAN1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MUN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the spectrin family.|||cell cortex|||cytoskeleton http://togogenome.org/gene/9555:ARL1 ^@ http://purl.uniprot.org/uniprot/A0A096N4C6 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9555:ACOX3 ^@ http://purl.uniprot.org/uniprot/A0A8I5R5Y9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/9555:SPPL3 ^@ http://purl.uniprot.org/uniprot/A0A096MYY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A22B family.|||Membrane http://togogenome.org/gene/9555:PYM1 ^@ http://purl.uniprot.org/uniprot/A0A096NFX7|||http://purl.uniprot.org/uniprot/A0A2I3MZ47 ^@ Similarity|||Subunit ^@ Belongs to the pym family.|||Interacts (via N-terminus) with magoh and rbm8a; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex. http://togogenome.org/gene/9555:TCP11L1 ^@ http://purl.uniprot.org/uniprot/A0A096NR17 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/9555:PITHD1 ^@ http://purl.uniprot.org/uniprot/A0A096NWC7 ^@ Similarity ^@ Belongs to the PITHD1 family. http://togogenome.org/gene/9555:MRRF ^@ http://purl.uniprot.org/uniprot/A0A096P0N4 ^@ Function|||Similarity ^@ Belongs to the RRF family.|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/9555:FGF10 ^@ http://purl.uniprot.org/uniprot/A0A8I5NP27 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9555:ACSM3 ^@ http://purl.uniprot.org/uniprot/A0A096NH85 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9555:LDB2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LUR7 ^@ Similarity ^@ Belongs to the LDB family. http://togogenome.org/gene/9555:PRKCD ^@ http://purl.uniprot.org/uniprot/A0A096NG19 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression.|||Cytoplasm|||Interacts with PDPK1 (via N-terminal region), RAD9A, CDCP1, MUC1 and VASP.|||Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.|||Nucleus|||perinuclear region http://togogenome.org/gene/9555:ALOX5 ^@ http://purl.uniprot.org/uniprot/A0A096P488 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the lipoxygenase family.|||Binds 1 Fe cation per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:NOG ^@ http://purl.uniprot.org/uniprot/A0A096MQZ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the noggin family.|||Homodimer.|||Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.|||Secreted http://togogenome.org/gene/9555:AP3M1 ^@ http://purl.uniprot.org/uniprot/A0A096P4K2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. http://togogenome.org/gene/9555:PLA2G2D ^@ http://purl.uniprot.org/uniprot/A0A8I5NH21 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9555:PHC3 ^@ http://purl.uniprot.org/uniprot/A0A096MT25|||http://purl.uniprot.org/uniprot/A0A2I3MT48 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:DPYSL4 ^@ http://purl.uniprot.org/uniprot/A0A096NSV5 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/9555:NECAP2 ^@ http://purl.uniprot.org/uniprot/A0A096MU17|||http://purl.uniprot.org/uniprot/A0A2I3LDM2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NECAP family.|||Involved in endocytosis.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9555:ADGRA3 ^@ http://purl.uniprot.org/uniprot/A0A096NZJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Membrane http://togogenome.org/gene/9555:IFT57 ^@ http://purl.uniprot.org/uniprot/A0A096NDI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFT57 family.|||cilium basal body http://togogenome.org/gene/9555:SULT1E1 ^@ http://purl.uniprot.org/uniprot/A0A096NSK0 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9555:LOC101017387 ^@ http://purl.uniprot.org/uniprot/A0A096NAA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NXF family.|||Cytoplasm http://togogenome.org/gene/9555:GRK6 ^@ http://purl.uniprot.org/uniprot/A0A2I3MBD9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9555:SUDS3 ^@ http://purl.uniprot.org/uniprot/A0A096MU64 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:DNASE1 ^@ http://purl.uniprot.org/uniprot/A0A096NLC7 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/9555:USP15 ^@ http://purl.uniprot.org/uniprot/A0A2I3M5A9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Cytoplasm http://togogenome.org/gene/9555:ALLC ^@ http://purl.uniprot.org/uniprot/A0A096NIM5 ^@ Function|||Similarity ^@ Belongs to the allantoicase family.|||The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals. http://togogenome.org/gene/9555:CS ^@ http://purl.uniprot.org/uniprot/A0A096NH04|||http://purl.uniprot.org/uniprot/A0A2I3LP12 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the citrate synthase family.|||Homodimer.|||Mitochondrion matrix http://togogenome.org/gene/9555:TRAPPC1 ^@ http://purl.uniprot.org/uniprot/A0A096P2S9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/9555:GJA1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NEY0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Endoplasmic reticulum|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9555:TPMT ^@ http://purl.uniprot.org/uniprot/A0A2I3MJF6 ^@ Similarity|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.|||Monomer. http://togogenome.org/gene/9555:GUCA2A ^@ http://purl.uniprot.org/uniprot/A0A096NYY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylin family.|||Secreted http://togogenome.org/gene/9555:CCNYL1 ^@ http://purl.uniprot.org/uniprot/A0A096MLE9|||http://purl.uniprot.org/uniprot/A0A2I3NGB4 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin Y subfamily. http://togogenome.org/gene/9555:GMFG ^@ http://purl.uniprot.org/uniprot/A0A2I3M1E3 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. GMF subfamily. http://togogenome.org/gene/9555:KCTD13 ^@ http://purl.uniprot.org/uniprot/A0A096NMK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BACURD family.|||Cell membrane http://togogenome.org/gene/9555:TLCD3B ^@ http://purl.uniprot.org/uniprot/A0A2I3M8G4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:FANCC ^@ http://purl.uniprot.org/uniprot/A0A096P263 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. This complex may also include HSP70.|||DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.|||Nucleus http://togogenome.org/gene/9555:VAPB ^@ http://purl.uniprot.org/uniprot/A0A096NNH6|||http://purl.uniprot.org/uniprot/A0A8I5N9X4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:CELF6 ^@ http://purl.uniprot.org/uniprot/A0A096NMM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CELF/BRUNOL family.|||Nucleus http://togogenome.org/gene/9555:RPL10A ^@ http://purl.uniprot.org/uniprot/A0A2I3LZJ5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL1 family. http://togogenome.org/gene/9555:AP1S3 ^@ http://purl.uniprot.org/uniprot/A0A096N0P2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||Membrane|||clathrin-coated pit http://togogenome.org/gene/9555:GJB2 ^@ http://purl.uniprot.org/uniprot/A0A096NEK9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Beta-type (group I) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9555:SPAG9 ^@ http://purl.uniprot.org/uniprot/A0A096P4M2|||http://purl.uniprot.org/uniprot/A0A096P4M3 ^@ Similarity ^@ Belongs to the JIP scaffold family. http://togogenome.org/gene/9555:PAX9 ^@ http://purl.uniprot.org/uniprot/A0A096NUN1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:METAP1D ^@ http://purl.uniprot.org/uniprot/A0A096NZJ2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/9555:DNAJC16 ^@ http://purl.uniprot.org/uniprot/A0A096NEQ5 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Plays an important role in regulating the size of autophagosomes during the formation process. http://togogenome.org/gene/9555:MCM10 ^@ http://purl.uniprot.org/uniprot/A0A096P3G3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM10 family.|||Nucleus http://togogenome.org/gene/9555:TEKT5 ^@ http://purl.uniprot.org/uniprot/A0A096NLN3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/9555:MCM4 ^@ http://purl.uniprot.org/uniprot/A0A096NDL7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/9555:OPN1SW ^@ http://purl.uniprot.org/uniprot/A0A096NUC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane|||Photoreceptor inner segment|||perinuclear region|||photoreceptor outer segment http://togogenome.org/gene/9555:UGP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LCU6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDPGP type 1 family.|||Homooctamer.|||UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. http://togogenome.org/gene/9555:RPS6KA1 ^@ http://purl.uniprot.org/uniprot/A0A096MS33|||http://purl.uniprot.org/uniprot/A0A2I3M5W9|||http://purl.uniprot.org/uniprot/A0A2I3NAK5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9555:DESI2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LL11 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/9555:RPS24 ^@ http://purl.uniprot.org/uniprot/A0A2I3LT27|||http://purl.uniprot.org/uniprot/A0A2I3MDJ9|||http://purl.uniprot.org/uniprot/A0A2I3N7A7|||http://purl.uniprot.org/uniprot/A0A2I3N8X3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/9555:CD27 ^@ http://purl.uniprot.org/uniprot/A0A096NPM5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:SERBP1 ^@ http://purl.uniprot.org/uniprot/A0A8I5MVB9 ^@ Similarity ^@ Belongs to the SERBP1-HABP4 family. http://togogenome.org/gene/9555:GRM4 ^@ http://purl.uniprot.org/uniprot/A0A2I3LLZ3|||http://purl.uniprot.org/uniprot/A0A2I3M1N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:MLF2 ^@ http://purl.uniprot.org/uniprot/A0A096MYD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MLF family.|||Cytoplasm http://togogenome.org/gene/9555:LOC101025074 ^@ http://purl.uniprot.org/uniprot/A0A2I3NEH1 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9555:ATP5MC1 ^@ http://purl.uniprot.org/uniprot/A0A096P441|||http://purl.uniprot.org/uniprot/A0A2I3LI66 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/9555:IDH3A ^@ http://purl.uniprot.org/uniprot/A0A2I3N7H1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.|||Mitochondrion http://togogenome.org/gene/9555:CD151 ^@ http://purl.uniprot.org/uniprot/A0A2I3NAE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9555:TRAPPC2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NF13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||perinuclear region http://togogenome.org/gene/9555:XPO7 ^@ http://purl.uniprot.org/uniprot/A0A096MT36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:MAP7D2 ^@ http://purl.uniprot.org/uniprot/A0A096MTI4|||http://purl.uniprot.org/uniprot/A0A2I3LDY3 ^@ Similarity ^@ Belongs to the MAP7 family. http://togogenome.org/gene/9555:FGF14 ^@ http://purl.uniprot.org/uniprot/A0A096MZU3|||http://purl.uniprot.org/uniprot/A0A2I3N608 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9555:CAPN10 ^@ http://purl.uniprot.org/uniprot/A0A096NA77 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9555:TATDN1 ^@ http://purl.uniprot.org/uniprot/A0A096MTI9 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. http://togogenome.org/gene/9555:GIMAP4 ^@ http://purl.uniprot.org/uniprot/A0A096MZP3 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9555:COPS8 ^@ http://purl.uniprot.org/uniprot/A0A096NWX9|||http://purl.uniprot.org/uniprot/A0A8I5R8Z3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN8 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:VPS37A ^@ http://purl.uniprot.org/uniprot/A0A096MZ12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9555:TPX2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MEM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TPX2 family.|||Nucleus|||spindle pole http://togogenome.org/gene/9555:SEC11A ^@ http://purl.uniprot.org/uniprot/A0A096NN18|||http://purl.uniprot.org/uniprot/A0A2I3LM76|||http://purl.uniprot.org/uniprot/A0A2I3MEZ6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Component of the signal peptidase complex.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:CLP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3M413 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Clp1 family. Clp1 subfamily.|||Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54. Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK.|||Nucleus|||Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing. http://togogenome.org/gene/9555:LOC100997984 ^@ http://purl.uniprot.org/uniprot/A0A8I5NBP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:GRB2 ^@ http://purl.uniprot.org/uniprot/A0A096NSU8 ^@ Subcellular Location Annotation ^@ Endosome|||Golgi apparatus|||Nucleus http://togogenome.org/gene/9555:KCNC2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LCY1|||http://purl.uniprot.org/uniprot/A0A2I3LJN5|||http://purl.uniprot.org/uniprot/A0A2I3LLY5|||http://purl.uniprot.org/uniprot/A0A2I3M2X2|||http://purl.uniprot.org/uniprot/A0A2I3M541|||http://purl.uniprot.org/uniprot/A0A2I3NB78|||http://purl.uniprot.org/uniprot/A0A8I5N0C3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9555:TAF12 ^@ http://purl.uniprot.org/uniprot/A0A096N6R4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF12 family.|||Nucleus http://togogenome.org/gene/9555:VCAM1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LIA6 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9555:DLG2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LPJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Membrane http://togogenome.org/gene/9555:IRAK4 ^@ http://purl.uniprot.org/uniprot/A0A8I5NF73 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.|||Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.|||Cytoplasm|||Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. http://togogenome.org/gene/9555:SDC4 ^@ http://purl.uniprot.org/uniprot/A4K2N4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane http://togogenome.org/gene/9555:BBS2 ^@ http://purl.uniprot.org/uniprot/A0A096NII1 ^@ Subcellular Location Annotation ^@ centriolar satellite|||cilium membrane http://togogenome.org/gene/9555:CYGB ^@ http://purl.uniprot.org/uniprot/A0A096NT41 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9555:MCUR1 ^@ http://purl.uniprot.org/uniprot/A0A096NL14 ^@ Similarity ^@ Belongs to the CCDC90 family. http://togogenome.org/gene/9555:TSN ^@ http://purl.uniprot.org/uniprot/A0A2I3LLA4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the translin family.|||DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.|||Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.|||Nucleus|||Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring. http://togogenome.org/gene/9555:ANAPC4 ^@ http://purl.uniprot.org/uniprot/A0A096NZK6 ^@ Function|||Similarity ^@ Belongs to the APC4 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. http://togogenome.org/gene/9555:TTC9B ^@ http://purl.uniprot.org/uniprot/A0A8I5NIR5 ^@ Similarity ^@ Belongs to the TTC9 family. http://togogenome.org/gene/9555:AP1S1 ^@ http://purl.uniprot.org/uniprot/A0A096NR44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||Membrane|||clathrin-coated pit http://togogenome.org/gene/9555:FAM229A ^@ http://purl.uniprot.org/uniprot/A0A096NS24 ^@ Similarity ^@ Belongs to the FAM229 family. http://togogenome.org/gene/9555:GINS2 ^@ http://purl.uniprot.org/uniprot/A0A096P0A9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS2/PSF2 family.|||Chromosome|||Component of the GINS complex.|||Nucleus http://togogenome.org/gene/9555:THG1L ^@ http://purl.uniprot.org/uniprot/A0A8I5NUY6 ^@ Cofactor|||Function|||Similarity ^@ Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.|||Belongs to the tRNA(His) guanylyltransferase family.|||Binds 2 magnesium ions per subunit. http://togogenome.org/gene/9555:MCM2 ^@ http://purl.uniprot.org/uniprot/A0A2I3NGA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Chromosome|||Nucleus http://togogenome.org/gene/9555:GDPD1 ^@ http://purl.uniprot.org/uniprot/A0A096P4W5|||http://purl.uniprot.org/uniprot/A0A2I3MAN2 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9555:HMGB3 ^@ http://purl.uniprot.org/uniprot/A0A096N0I4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/9555:DYNLRB2 ^@ http://purl.uniprot.org/uniprot/A0A096NAA4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.|||Belongs to the GAMAD family.|||Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.|||cytoskeleton http://togogenome.org/gene/9555:L3HYPDH ^@ http://purl.uniprot.org/uniprot/A0A096NVE9|||http://purl.uniprot.org/uniprot/A0A8I5N5V6|||http://purl.uniprot.org/uniprot/A0A8I5R5D9 ^@ Similarity ^@ Belongs to the proline racemase family. http://togogenome.org/gene/9555:SLC43A3 ^@ http://purl.uniprot.org/uniprot/A0A096NA59 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:PXMP2 ^@ http://purl.uniprot.org/uniprot/A0A096N051 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/9555:C13H9orf78 ^@ http://purl.uniprot.org/uniprot/A0A096P0G8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TLS1 family.|||Nucleus http://togogenome.org/gene/9555:RP2 ^@ http://purl.uniprot.org/uniprot/A0A096NXT9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.|||Belongs to the TBCC family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:SIM2 ^@ http://purl.uniprot.org/uniprot/A0A096NJ48 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:SNTB2 ^@ http://purl.uniprot.org/uniprot/A0A096NW43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntrophin family.|||Cell junction|||cytoskeleton http://togogenome.org/gene/9555:STOM ^@ http://purl.uniprot.org/uniprot/A0A096P0P4 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/9555:MRPL33 ^@ http://purl.uniprot.org/uniprot/A0A8I5NHT6 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/9555:FZD1 ^@ http://purl.uniprot.org/uniprot/B0CM30 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:PLAU ^@ http://purl.uniprot.org/uniprot/A0A2I3LJZ4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:HMCES ^@ http://purl.uniprot.org/uniprot/A0A096NPF5 ^@ Function|||Similarity ^@ Belongs to the SOS response-associated peptidase family.|||Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction. http://togogenome.org/gene/9555:SNX4 ^@ http://purl.uniprot.org/uniprot/A0A096MZ19 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9555:IDI1 ^@ http://purl.uniprot.org/uniprot/A0A096P372 ^@ Function|||Similarity ^@ Belongs to the IPP isomerase type 1 family.|||Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). http://togogenome.org/gene/9555:SDHB ^@ http://purl.uniprot.org/uniprot/A0A096MXT4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster.|||Binds 1 [3Fe-4S] cluster.|||Binds 1 [4Fe-4S] cluster.|||Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/9555:CDPF1 ^@ http://purl.uniprot.org/uniprot/A0A096NKS1 ^@ Similarity ^@ Belongs to the CDPF1 family. http://togogenome.org/gene/9555:KCNK12 ^@ http://purl.uniprot.org/uniprot/A0A096NF36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9555:CPNE1 ^@ http://purl.uniprot.org/uniprot/A0A2I3M2D2|||http://purl.uniprot.org/uniprot/B0CM83 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9555:AGTRAP ^@ http://purl.uniprot.org/uniprot/A0A096N8D6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:RPL36 ^@ http://purl.uniprot.org/uniprot/A0A2I3LML8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL36 family. http://togogenome.org/gene/9555:RAB33A ^@ http://purl.uniprot.org/uniprot/A0A096NAK1 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Rab family. http://togogenome.org/gene/9555:MYADML2 ^@ http://purl.uniprot.org/uniprot/A0A096N4U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAL family.|||Membrane http://togogenome.org/gene/9555:MEIG1 ^@ http://purl.uniprot.org/uniprot/A0A096P3J1 ^@ Function|||Similarity ^@ Belongs to the MEIG1 family.|||Essential for spermiogenesis. http://togogenome.org/gene/9555:LDLRAD4 ^@ http://purl.uniprot.org/uniprot/A0A096N1L6|||http://purl.uniprot.org/uniprot/A0A2I3M357|||http://purl.uniprot.org/uniprot/A0A2I3MU42 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMEPA1 family.|||Early endosome membrane|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:STAC ^@ http://purl.uniprot.org/uniprot/A0A096NC88 ^@ Subcellular Location Annotation ^@ sarcolemma http://togogenome.org/gene/9555:PIGL ^@ http://purl.uniprot.org/uniprot/A0A8I5P3L5 ^@ Function|||Similarity ^@ Belongs to the PIGL family.|||Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol. http://togogenome.org/gene/9555:KMT5B ^@ http://purl.uniprot.org/uniprot/A0A2I3LWW0 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus http://togogenome.org/gene/9555:LZTS2 ^@ http://purl.uniprot.org/uniprot/A0A096P6A7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LZTS2 family.|||Cytoplasm|||Interacts with KATNB1. Also interacts with CTNNB1, gamma-tubulin and KIF23.|||Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.|||centrosome http://togogenome.org/gene/9555:NDUFAF1 ^@ http://purl.uniprot.org/uniprot/A0A096NTM8 ^@ Function|||Similarity ^@ As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.|||Belongs to the CIA30 family. http://togogenome.org/gene/9555:SLC1A4 ^@ http://purl.uniprot.org/uniprot/A0A096P070 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9555:NXPH1 ^@ http://purl.uniprot.org/uniprot/A0A096NWV2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/9555:CXCL13 ^@ http://purl.uniprot.org/uniprot/A0A8I5NEX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9555:TM9SF3 ^@ http://purl.uniprot.org/uniprot/A0A2I3M736 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/9555:ARPC5 ^@ http://purl.uniprot.org/uniprot/A0A2I3NHC2 ^@ Function|||Similarity ^@ Belongs to the ARPC5 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. http://togogenome.org/gene/9555:LAMP1 ^@ http://purl.uniprot.org/uniprot/A0A096MXK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9555:SLC35E3 ^@ http://purl.uniprot.org/uniprot/A0A096N130 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:CDA ^@ http://purl.uniprot.org/uniprot/A0A096N207 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||Cytoplasm|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/9555:LOC101006107 ^@ http://purl.uniprot.org/uniprot/R4TIY2 ^@ Similarity ^@ Belongs to the apolipoprotein L family. http://togogenome.org/gene/9555:BRINP2 ^@ http://purl.uniprot.org/uniprot/A0A096MSY9 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/9555:WNT5A ^@ http://purl.uniprot.org/uniprot/A0A096MZ93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9555:SMARCA1 ^@ http://purl.uniprot.org/uniprot/A0A096MU89|||http://purl.uniprot.org/uniprot/A0A2I3MUW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.|||Nucleus http://togogenome.org/gene/9555:STAC2 ^@ http://purl.uniprot.org/uniprot/A0A096P5A6 ^@ Subcellular Location Annotation ^@ sarcolemma http://togogenome.org/gene/9555:PTX3 ^@ http://purl.uniprot.org/uniprot/A0A096N0W7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:CDK14 ^@ http://purl.uniprot.org/uniprot/B0CM29 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:SSBP1 ^@ http://purl.uniprot.org/uniprot/A0A096MTD7 ^@ Subcellular Location Annotation ^@ mitochondrion nucleoid http://togogenome.org/gene/9555:CNOT6 ^@ http://purl.uniprot.org/uniprot/A0A096MLC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCR4/nocturin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:MOXD1 ^@ http://purl.uniprot.org/uniprot/A9X181 ^@ Similarity ^@ Belongs to the copper type II ascorbate-dependent monooxygenase family. http://togogenome.org/gene/9555:TNFAIP6 ^@ http://purl.uniprot.org/uniprot/A0A096MTD2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:SLC30A1 ^@ http://purl.uniprot.org/uniprot/A0A8I5R831 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9555:SLC16A9 ^@ http://purl.uniprot.org/uniprot/A0A096P569 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:GRPEL2 ^@ http://purl.uniprot.org/uniprot/A0A096NEX1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GrpE family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion matrix http://togogenome.org/gene/9555:PSMB4 ^@ http://purl.uniprot.org/uniprot/A9X1A3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1B family.|||Cytoplasm|||Non-catalytic component of the proteasome.|||Nucleus http://togogenome.org/gene/9555:GLRX ^@ http://purl.uniprot.org/uniprot/A0A096N4P5 ^@ Function|||Similarity ^@ Belongs to the glutaredoxin family.|||Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. http://togogenome.org/gene/9555:POLR2I ^@ http://purl.uniprot.org/uniprot/A0A0A0MV17 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/9555:ESR2 ^@ http://purl.uniprot.org/uniprot/B6CK32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/9555:AMER2 ^@ http://purl.uniprot.org/uniprot/A0A096N0C8 ^@ Similarity ^@ Belongs to the Amer family. http://togogenome.org/gene/9555:MDM2 ^@ http://purl.uniprot.org/uniprot/A0A2I3NF10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM2/MDM4 family.|||Cytoplasm|||nucleolus|||nucleoplasm http://togogenome.org/gene/9555:A1CF ^@ http://purl.uniprot.org/uniprot/A0A096P594 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:PSMD3 ^@ http://purl.uniprot.org/uniprot/A0A096P5D9 ^@ Similarity ^@ Belongs to the proteasome subunit S3 family. http://togogenome.org/gene/9555:TMEM98 ^@ http://purl.uniprot.org/uniprot/A0A096P3T1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM98 family.|||Endoplasmic reticulum membrane|||Membrane|||extracellular exosome http://togogenome.org/gene/9555:UBP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LMV6|||http://purl.uniprot.org/uniprot/A0A2I3NGH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus http://togogenome.org/gene/9555:USP39 ^@ http://purl.uniprot.org/uniprot/A0A096NZV3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:LOC101025927 ^@ http://purl.uniprot.org/uniprot/A0A096NFW6 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/9555:SRPX2 ^@ http://purl.uniprot.org/uniprot/A0A096N1S5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:PPP1R3C ^@ http://purl.uniprot.org/uniprot/A0A096P5H4 ^@ Domain|||Function|||Subunit ^@ Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.|||Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.|||The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase. http://togogenome.org/gene/9555:MAP2K1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LF26 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:NPTX2 ^@ http://purl.uniprot.org/uniprot/A0A096NSG2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:LOC101018035 ^@ http://purl.uniprot.org/uniprot/A0A2I3LTH8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/9555:HSD17B7 ^@ http://purl.uniprot.org/uniprot/A0A096NCZ2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily. http://togogenome.org/gene/9555:JRKL ^@ http://purl.uniprot.org/uniprot/A0A096N9H7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:SCN1B ^@ http://purl.uniprot.org/uniprot/A0A0A0MX70 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:CHPF ^@ http://purl.uniprot.org/uniprot/A0A096MV62|||http://purl.uniprot.org/uniprot/B0CM54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9555:MAB21L2 ^@ http://purl.uniprot.org/uniprot/A0A096ML90 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9555:ST6GALNAC4 ^@ http://purl.uniprot.org/uniprot/A0A096P1Z2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9555:BAK1 ^@ http://purl.uniprot.org/uniprot/A0A8I5MWU4 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9555:PEMT ^@ http://purl.uniprot.org/uniprot/A0A096P320|||http://purl.uniprot.org/uniprot/A0A2I3NBV6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.|||Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9555:CLRN3 ^@ http://purl.uniprot.org/uniprot/A0A096NSS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/9555:CD40 ^@ http://purl.uniprot.org/uniprot/U5LKV0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:OXT ^@ http://purl.uniprot.org/uniprot/A0A096NV92 ^@ Similarity ^@ Belongs to the vasopressin/oxytocin family. http://togogenome.org/gene/9555:ZDHHC7 ^@ http://purl.uniprot.org/uniprot/A0A2I3MZH6 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9555:DEUP1 ^@ http://purl.uniprot.org/uniprot/A0A096MXY7 ^@ Similarity ^@ Belongs to the CEP63 family. http://togogenome.org/gene/9555:RPL18A ^@ http://purl.uniprot.org/uniprot/A0A2I3M759 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL20 family. http://togogenome.org/gene/9555:EIF1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LYE3 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/9555:EDNRA ^@ http://purl.uniprot.org/uniprot/A0A8I5N0F2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with HDAC7 and KAT5.|||Membrane|||Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. http://togogenome.org/gene/9555:ELF3 ^@ http://purl.uniprot.org/uniprot/A0A096N6I9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9555:GNG7 ^@ http://purl.uniprot.org/uniprot/A0A0A0MW42 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9555:FTSJ3 ^@ http://purl.uniprot.org/uniprot/A0A096P6F9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.|||Interacts with NIP7.|||Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.|||nucleolus http://togogenome.org/gene/9555:TGFBR1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LUA8|||http://purl.uniprot.org/uniprot/A0A2I3NGA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9555:KRT34 ^@ http://purl.uniprot.org/uniprot/A0A2I3MSY3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9555:ATP5F1C ^@ http://purl.uniprot.org/uniprot/A0A096P3D8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase gamma chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. http://togogenome.org/gene/9555:EEF1AKMT1 ^@ http://purl.uniprot.org/uniprot/A0A096MQR7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.|||Cytoplasm|||Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.|||Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure. http://togogenome.org/gene/9555:FN1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LTG6|||http://purl.uniprot.org/uniprot/A0A2I3MT85|||http://purl.uniprot.org/uniprot/A0A2I3NHH6 ^@ Function ^@ Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling. http://togogenome.org/gene/9555:TBC1D23 ^@ http://purl.uniprot.org/uniprot/A0A096MV73|||http://purl.uniprot.org/uniprot/A0A2I3MPR1|||http://purl.uniprot.org/uniprot/A0A2I3MR56 ^@ Subcellular Location Annotation ^@ trans-Golgi network http://togogenome.org/gene/9555:PCMT1 ^@ http://purl.uniprot.org/uniprot/A0A096NW19 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/9555:SERINC3 ^@ http://purl.uniprot.org/uniprot/A0A096NX96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9555:POMT2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NL25 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/9555:PDGFA ^@ http://purl.uniprot.org/uniprot/A0A096P4E8|||http://purl.uniprot.org/uniprot/A0A8I5MZ26 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/9555:DOLPP1 ^@ http://purl.uniprot.org/uniprot/B0CM95 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dolichyldiphosphatase family.|||Endoplasmic reticulum membrane|||Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate (By similarity). http://togogenome.org/gene/9555:SORCS3 ^@ http://purl.uniprot.org/uniprot/A0A096P6J4 ^@ Similarity ^@ Belongs to the VPS10-related sortilin family. SORCS subfamily. http://togogenome.org/gene/9555:CDC42EP3 ^@ http://purl.uniprot.org/uniprot/A0A096MLW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/9555:NFKB2 ^@ http://purl.uniprot.org/uniprot/A0A096P6E6 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9555:SLC24A4 ^@ http://purl.uniprot.org/uniprot/A0A096NJE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/9555:CCR4 ^@ http://purl.uniprot.org/uniprot/A0A096NRU6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9555:TCTEX1D4 ^@ http://purl.uniprot.org/uniprot/A0A8I5NBU8 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/9555:SLC1A7 ^@ http://purl.uniprot.org/uniprot/A0A096MP46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9555:DKK4 ^@ http://purl.uniprot.org/uniprot/A0A096N0D4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/9555:TMEM17 ^@ http://purl.uniprot.org/uniprot/A0A8I5P183 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:LOC101009148 ^@ http://purl.uniprot.org/uniprot/A0A096NDZ6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/9555:UROC1 ^@ http://purl.uniprot.org/uniprot/A0A096N3T9 ^@ Similarity ^@ Belongs to the urocanase family. http://togogenome.org/gene/9555:FXN ^@ http://purl.uniprot.org/uniprot/A0A096P1P8 ^@ Similarity ^@ Belongs to the frataxin family. http://togogenome.org/gene/9555:SLC16A4 ^@ http://purl.uniprot.org/uniprot/A0A2I3N133|||http://purl.uniprot.org/uniprot/A0A2I3N8V3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:CSTF3 ^@ http://purl.uniprot.org/uniprot/A0A2I3NAD4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:PEX12 ^@ http://purl.uniprot.org/uniprot/A0A096P3X3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pex2/pex10/pex12 family.|||Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9555:RAB5IF ^@ http://purl.uniprot.org/uniprot/A0A2I3MS51|||http://purl.uniprot.org/uniprot/A0A8I5N4Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMC6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:GDI1 ^@ http://purl.uniprot.org/uniprot/A9CB64 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP. http://togogenome.org/gene/9555:FGGY ^@ http://purl.uniprot.org/uniprot/A0A2I3NC90 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/9555:SCML1 ^@ http://purl.uniprot.org/uniprot/A0A096MUK8 ^@ Similarity ^@ Belongs to the SCM family. http://togogenome.org/gene/9555:SPACA4 ^@ http://purl.uniprot.org/uniprot/A0A8I5P293 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPACA4/bouncer family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:LOC108584677 ^@ http://purl.uniprot.org/uniprot/A0A096N461 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/9555:PRKACG ^@ http://purl.uniprot.org/uniprot/A0A8I5NND5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/9555:KIF3C ^@ http://purl.uniprot.org/uniprot/A0A096NQJ2 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9555:KCTD10 ^@ http://purl.uniprot.org/uniprot/A0A096MXR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BACURD family.|||Cell membrane http://togogenome.org/gene/9555:SLC19A2 ^@ http://purl.uniprot.org/uniprot/A0A096N995 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.|||Cell membrane|||High-affinity transporter for the intake of thiamine. http://togogenome.org/gene/9555:GALNT12 ^@ http://purl.uniprot.org/uniprot/A0A096P120 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9555:DUSP6 ^@ http://purl.uniprot.org/uniprot/A0A8I5N5Q9 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9555:RBM3 ^@ http://purl.uniprot.org/uniprot/A0A2I3MGL6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:TLCD4 ^@ http://purl.uniprot.org/uniprot/A0A096NYV9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:SEC22A ^@ http://purl.uniprot.org/uniprot/A0A096NDB6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||May be involved in vesicle transport between the ER and the Golgi complex.|||Membrane http://togogenome.org/gene/9555:FCN1 ^@ http://purl.uniprot.org/uniprot/A0A2I3M827 ^@ Similarity ^@ Belongs to the ficolin lectin family. http://togogenome.org/gene/9555:APOOL ^@ http://purl.uniprot.org/uniprot/A0A2I3NDK4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:STRADA ^@ http://purl.uniprot.org/uniprot/A0A096P6E5|||http://purl.uniprot.org/uniprot/A0A2I3LD26 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. http://togogenome.org/gene/9555:ENTPD7 ^@ http://purl.uniprot.org/uniprot/A0A2I3LXS3 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9555:POP5 ^@ http://purl.uniprot.org/uniprot/A0A096N4C1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family.|||Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.|||nucleolus http://togogenome.org/gene/9555:CSF2 ^@ http://purl.uniprot.org/uniprot/Q865Y5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GM-CSF family.|||Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.|||Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.|||Secreted http://togogenome.org/gene/9555:SNRPF ^@ http://purl.uniprot.org/uniprot/A0A096MLH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/9555:PICALM ^@ http://purl.uniprot.org/uniprot/A0A2I3N8P8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PICALM/SNAP91 family.|||Membrane http://togogenome.org/gene/9555:SLC35D1 ^@ http://purl.uniprot.org/uniprot/A0A096MZF6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:SERPINE2 ^@ http://purl.uniprot.org/uniprot/A0A096NYG6 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9555:PSAP ^@ http://purl.uniprot.org/uniprot/A0A2I3M011 ^@ Function|||Subcellular Location Annotation ^@ Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.|||Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.|||Secreted http://togogenome.org/gene/9555:ARFGEF2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MGI6 ^@ Subcellular Location Annotation ^@ Golgi apparatus|||perinuclear region http://togogenome.org/gene/9555:MAU2 ^@ http://purl.uniprot.org/uniprot/A0A0A0MV22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCC4/mau-2 family.|||nucleoplasm http://togogenome.org/gene/9555:LOC103876009 ^@ http://purl.uniprot.org/uniprot/A0A8I5NFY8 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9555:VKORC1 ^@ http://purl.uniprot.org/uniprot/A0A096NHX6|||http://purl.uniprot.org/uniprot/A0A2I3M7W5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VKOR family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:ITM2B ^@ http://purl.uniprot.org/uniprot/A0A096N2U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITM2 family.|||Membrane http://togogenome.org/gene/9555:NUBPL ^@ http://purl.uniprot.org/uniprot/A0A096MNH0 ^@ Similarity ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. http://togogenome.org/gene/9555:EID2 ^@ http://purl.uniprot.org/uniprot/A0A0A0MWE4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:ADORA1 ^@ http://purl.uniprot.org/uniprot/A0A096NBH2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. http://togogenome.org/gene/9555:DDO ^@ http://purl.uniprot.org/uniprot/A0A096MS66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAMOX/DASOX family.|||Peroxisome http://togogenome.org/gene/9555:SLC5A4 ^@ http://purl.uniprot.org/uniprot/A9CB41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:GNB3 ^@ http://purl.uniprot.org/uniprot/A0A096N052 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/9555:SERPINA1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MI08 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9555:POLR2H ^@ http://purl.uniprot.org/uniprot/A0A2I3NH56 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RPB8 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. http://togogenome.org/gene/9555:MTNR1A ^@ http://purl.uniprot.org/uniprot/A0A096MY52 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.|||Membrane http://togogenome.org/gene/9555:ST8SIA3 ^@ http://purl.uniprot.org/uniprot/A0A096MUQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9555:CACNB4 ^@ http://purl.uniprot.org/uniprot/A0A2I3M2Z4|||http://purl.uniprot.org/uniprot/A0A2I3M9B2|||http://purl.uniprot.org/uniprot/A0A2I3NBP9|||http://purl.uniprot.org/uniprot/A0A2I3NE56 ^@ Similarity ^@ Belongs to the calcium channel beta subunit family. http://togogenome.org/gene/9555:MSTN ^@ http://purl.uniprot.org/uniprot/A0A096NPW9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts specifically as a negative regulator of skeletal muscle growth.|||Belongs to the TGF-beta family.|||Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FSTL3.|||Secreted http://togogenome.org/gene/9555:STAC3 ^@ http://purl.uniprot.org/uniprot/A0A096N7H5 ^@ Subcellular Location Annotation ^@ sarcolemma http://togogenome.org/gene/9555:RNF141 ^@ http://purl.uniprot.org/uniprot/A0A096N839 ^@ Function ^@ May be involved in spermatogenesis. http://togogenome.org/gene/9555:PLPPR5 ^@ http://purl.uniprot.org/uniprot/A0A8I5N3Y2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9555:ATP6V0E1 ^@ http://purl.uniprot.org/uniprot/A0A096NDU2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase e1/e2 subunit family.|||Membrane|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9555:SLCO1C1 ^@ http://purl.uniprot.org/uniprot/A0A096NPQ2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:FGF9 ^@ http://purl.uniprot.org/uniprot/A0A2I3LM65 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9555:ASB6 ^@ http://purl.uniprot.org/uniprot/A0A096P0H3 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9555:CLCF1 ^@ http://purl.uniprot.org/uniprot/A0A096NQ61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-6 superfamily.|||Secreted http://togogenome.org/gene/9555:PDE3B ^@ http://purl.uniprot.org/uniprot/A0A096MMB6 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9555:LOC101005189 ^@ http://purl.uniprot.org/uniprot/A0A2I3M9T4|||http://purl.uniprot.org/uniprot/A0A2I3MHV2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argonaute family.|||Belongs to the argonaute family. Ago subfamily.|||Interacts with EIF4B, IMP8, PRMT5 and TNRC6B. Interacts with APOBEC3F, APOBEC3G and APOBEC3H.|||P-body|||Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. http://togogenome.org/gene/9555:ALDH4A1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MQP5 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9555:TRIT1 ^@ http://purl.uniprot.org/uniprot/A0A096MMW7 ^@ Function|||Similarity ^@ Belongs to the IPP transferase family.|||Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37. http://togogenome.org/gene/9555:OR51V1 ^@ http://purl.uniprot.org/uniprot/A9L8X6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:SCARB2 ^@ http://purl.uniprot.org/uniprot/A0A096MVW2 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/9555:APOA5 ^@ http://purl.uniprot.org/uniprot/A9CB28 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/9555:SEC31A ^@ http://purl.uniprot.org/uniprot/A0A096NWD8|||http://purl.uniprot.org/uniprot/A0A2I3M592|||http://purl.uniprot.org/uniprot/A0A2I3ME68|||http://purl.uniprot.org/uniprot/A0A2I3MWF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC31 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9555:ATG16L1 ^@ http://purl.uniprot.org/uniprot/A0A096MYC3|||http://purl.uniprot.org/uniprot/A0A2I3LK84|||http://purl.uniprot.org/uniprot/A0A2I3LRY7 ^@ Similarity ^@ Belongs to the WD repeat ATG16 family. http://togogenome.org/gene/9555:LSM5 ^@ http://purl.uniprot.org/uniprot/A0A2I3LH84|||http://purl.uniprot.org/uniprot/A0A2I3MJL0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. http://togogenome.org/gene/9555:NKD1 ^@ http://purl.uniprot.org/uniprot/A0A096NI81 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NKD family.|||Cell autonomous antagonist of the canonical Wnt signaling pathway.|||Cell membrane|||Cytoplasm http://togogenome.org/gene/9555:L3MBTL2 ^@ http://purl.uniprot.org/uniprot/A0A096NKA0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Nucleus|||Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, BAT8 and YAF2.|||Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. http://togogenome.org/gene/9555:TNFSF15 ^@ http://purl.uniprot.org/uniprot/A0A096P0S1 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9555:CELF3 ^@ http://purl.uniprot.org/uniprot/A9X1A8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CELF/BRUNOL family.|||Nucleus http://togogenome.org/gene/9555:AK2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LVZ0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK2 subfamily.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Mitochondrion intermembrane space|||Monomer. http://togogenome.org/gene/9555:NAF1 ^@ http://purl.uniprot.org/uniprot/A0A096N9N5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAF1 family.|||Nucleus http://togogenome.org/gene/9555:CPB2 ^@ http://purl.uniprot.org/uniprot/A0A096NA31 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9555:GPR37 ^@ http://purl.uniprot.org/uniprot/A0A8I5R605 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9555:TRNT1 ^@ http://purl.uniprot.org/uniprot/A0A096N3W8 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/9555:WNT6 ^@ http://purl.uniprot.org/uniprot/A0A096NCS2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9555:RANGRF ^@ http://purl.uniprot.org/uniprot/A0A096P2U5|||http://purl.uniprot.org/uniprot/A0A2I3NBM5 ^@ Similarity ^@ Belongs to the MOG1 family. http://togogenome.org/gene/9555:GNAI3 ^@ http://purl.uniprot.org/uniprot/A0A096NWS6 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9555:DUS4L ^@ http://purl.uniprot.org/uniprot/A0A096NWF6 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. http://togogenome.org/gene/9555:PTPA ^@ http://purl.uniprot.org/uniprot/A0A2I3LGK3|||http://purl.uniprot.org/uniprot/B0CM96 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTPA-type PPIase family.|||Cytoplasm|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9555:NEK9 ^@ http://purl.uniprot.org/uniprot/A0A096NS50 ^@ Similarity ^@ Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. http://togogenome.org/gene/9555:GALNT3 ^@ http://purl.uniprot.org/uniprot/A0A096N3U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9555:GNPNAT1 ^@ http://purl.uniprot.org/uniprot/A0A096NV33 ^@ Similarity|||Subunit ^@ Belongs to the acetyltransferase family. GNA1 subfamily.|||Homodimer. http://togogenome.org/gene/9555:LOC101003239 ^@ http://purl.uniprot.org/uniprot/A0A096NE90 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Component of the 40S small ribosomal subunit. http://togogenome.org/gene/9555:SMIM14 ^@ http://purl.uniprot.org/uniprot/A0A096NFP8 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9555:PFKFB1 ^@ http://purl.uniprot.org/uniprot/A0A096N833 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/9555:CD63 ^@ http://purl.uniprot.org/uniprot/A0A8I5NDR7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Cell membrane|||Cell surface|||Endosome membrane|||Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.|||Late endosome membrane|||Lysosome membrane|||Melanosome|||Membrane|||extracellular exosome|||multivesicular body http://togogenome.org/gene/9555:LOC101024168 ^@ http://purl.uniprot.org/uniprot/A0A096P2V0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/9555:KAT5 ^@ http://purl.uniprot.org/uniprot/A0A096MZF0|||http://purl.uniprot.org/uniprot/A0A2I3LEQ6|||http://purl.uniprot.org/uniprot/A0A2I3ME21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/9555:PRDX5 ^@ http://purl.uniprot.org/uniprot/A0A2I3M5Q3|||http://purl.uniprot.org/uniprot/A0A2I3MGG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxiredoxin family. Prx5 subfamily.|||Peroxisome matrix|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. http://togogenome.org/gene/9555:LOC101000155 ^@ http://purl.uniprot.org/uniprot/A0A2I3NDZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFI6/IFI27 family.|||Membrane http://togogenome.org/gene/9555:FXYD2 ^@ http://purl.uniprot.org/uniprot/A0A2I3M337 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FXYD family.|||May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.|||Membrane|||Regulatory subunit of the sodium/potassium-transporting ATPase which is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. http://togogenome.org/gene/9555:CSN3 ^@ http://purl.uniprot.org/uniprot/A0A096MZ44 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the kappa-casein family.|||Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.|||Secreted http://togogenome.org/gene/9555:FGF19 ^@ http://purl.uniprot.org/uniprot/A0A8I5N1F2 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9555:RNF185 ^@ http://purl.uniprot.org/uniprot/A0A096NJM1 ^@ Domain|||Function|||Subcellular Location Annotation ^@ E3 ubiquitin-protein ligase.|||Endoplasmic reticulum membrane|||Mitochondrion membrane|||The RING-type zinc finger domain is responsible for E3 ligase activity. http://togogenome.org/gene/9555:B3GNT2 ^@ http://purl.uniprot.org/uniprot/A0A096N903 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9555:DLL4 ^@ http://purl.uniprot.org/uniprot/A0A096NTJ5 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/9555:GLCE ^@ http://purl.uniprot.org/uniprot/A0A096NMI9 ^@ Similarity ^@ Belongs to the D-glucuronyl C5-epimerase family. http://togogenome.org/gene/9555:CCDC181 ^@ http://purl.uniprot.org/uniprot/A0A096N1C5|||http://purl.uniprot.org/uniprot/A0A8I5R2G8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC181 family.|||Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.|||cytoskeleton|||flagellum http://togogenome.org/gene/9555:RETREG1 ^@ http://purl.uniprot.org/uniprot/A0A096MVQ8|||http://purl.uniprot.org/uniprot/A0A2I3LF37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RETREG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:DEF8 ^@ http://purl.uniprot.org/uniprot/A0A096N5W7 ^@ Similarity ^@ Belongs to the DEF8 family. http://togogenome.org/gene/9555:ARF1 ^@ http://purl.uniprot.org/uniprot/A0A096NAX4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/9555:LIPT1 ^@ http://purl.uniprot.org/uniprot/A0A096NAR7 ^@ Similarity ^@ Belongs to the LplA family. http://togogenome.org/gene/9555:KCNJ6 ^@ http://purl.uniprot.org/uniprot/A0A096NJ31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.|||Membrane http://togogenome.org/gene/9555:UGT1A7 ^@ http://purl.uniprot.org/uniprot/Q20CL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9555:DSG2 ^@ http://purl.uniprot.org/uniprot/A0A096NXU8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||desmosome http://togogenome.org/gene/9555:CLPTM1 ^@ http://purl.uniprot.org/uniprot/A0A2I3M151|||http://purl.uniprot.org/uniprot/A0A2I3N0V0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLPTM1 family.|||Membrane http://togogenome.org/gene/9555:RHCG ^@ http://purl.uniprot.org/uniprot/A0A096NN77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/9555:GRIA4 ^@ http://purl.uniprot.org/uniprot/A0A096MR99|||http://purl.uniprot.org/uniprot/A0A2I3MYF0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/9555:CHMP6 ^@ http://purl.uniprot.org/uniprot/A0A096NTD0 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9555:SERPINA5 ^@ http://purl.uniprot.org/uniprot/A0A2I3MM37 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9555:LOC101012197 ^@ http://purl.uniprot.org/uniprot/A0A096NRW6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.|||Belongs to the sulfotransferase 6 family.|||Membrane http://togogenome.org/gene/9555:CSTB ^@ http://purl.uniprot.org/uniprot/A0A096NIL5 ^@ Similarity ^@ Belongs to the cystatin family. http://togogenome.org/gene/9555:ALG9 ^@ http://purl.uniprot.org/uniprot/A0A8I5RA68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:MAP3K8 ^@ http://purl.uniprot.org/uniprot/A0A2I3LEE9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/9555:CAMK2N2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LWU6 ^@ Similarity ^@ Belongs to the CAMK2N family. http://togogenome.org/gene/9555:EXTL3 ^@ http://purl.uniprot.org/uniprot/A0A096NYB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:ERGIC1 ^@ http://purl.uniprot.org/uniprot/A0A096NDR0|||http://purl.uniprot.org/uniprot/A0A2I3LVJ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/9555:CCT7 ^@ http://purl.uniprot.org/uniprot/A0A096MV48 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.|||Cytoplasm|||Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.|||Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. http://togogenome.org/gene/9555:BACE1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MIX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Endosome|||Membrane|||Membrane raft|||Recycling endosome|||Secreted|||trans-Golgi network http://togogenome.org/gene/9555:LRRC8B ^@ http://purl.uniprot.org/uniprot/A0A096MQI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:KCNG2 ^@ http://purl.uniprot.org/uniprot/A0A096MXT0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9555:CALB1 ^@ http://purl.uniprot.org/uniprot/A0A8I5R951 ^@ Function|||Similarity ^@ Belongs to the calbindin family.|||Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. http://togogenome.org/gene/9555:DDIT4L ^@ http://purl.uniprot.org/uniprot/A0A096MRX3 ^@ Similarity ^@ Belongs to the DDIT4 family. http://togogenome.org/gene/9555:HSPA14 ^@ http://purl.uniprot.org/uniprot/A0A2I3LTR9 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9555:CIAO2B ^@ http://purl.uniprot.org/uniprot/A0A096NJA3 ^@ Similarity ^@ Belongs to the MIP18 family. http://togogenome.org/gene/9555:MOGS ^@ http://purl.uniprot.org/uniprot/A0A096NR15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 63 family.|||Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9555:LOC101006121 ^@ http://purl.uniprot.org/uniprot/A0A8I5NZD6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9555:DDX5 ^@ http://purl.uniprot.org/uniprot/A0A2I3LR70 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily. http://togogenome.org/gene/9555:FAM114A1 ^@ http://purl.uniprot.org/uniprot/A0A096NXP6 ^@ Similarity ^@ Belongs to the FAM114 family. http://togogenome.org/gene/9555:HPX ^@ http://purl.uniprot.org/uniprot/A0A096N345 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the hemopexin family.|||Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.|||Secreted http://togogenome.org/gene/9555:IL12A ^@ http://purl.uniprot.org/uniprot/Q865Y2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-6 superfamily.|||Heterodimer with IL12B; disulfide-linked. This heterodimer is known as interleukin IL-12. Heterodimer with EBI3/IL27B; not disulfide-linked. This heterodimer is known as interleukin IL-35. Interacts with NBR1; this interaction promotes IL-12 secretion (By similarity).|||Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes (By similarity). As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine (By similarity). Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites (By similarity).|||Secreted http://togogenome.org/gene/9555:TMEFF2 ^@ http://purl.uniprot.org/uniprot/A0A096MY77 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:SLC9A3R2 ^@ http://purl.uniprot.org/uniprot/A0A096NL00|||http://purl.uniprot.org/uniprot/A0A2I3M5W8 ^@ Function|||Subcellular Location Annotation ^@ Apical cell membrane|||Cell membrane|||Endomembrane system|||Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. http://togogenome.org/gene/9555:VEZT ^@ http://purl.uniprot.org/uniprot/A0A096MX63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vezatin family.|||Cell membrane|||Membrane|||Nucleus|||adherens junction http://togogenome.org/gene/9555:DNASE2B ^@ http://purl.uniprot.org/uniprot/A0A096MYU6 ^@ Similarity ^@ Belongs to the DNase II family. http://togogenome.org/gene/9555:ARMC1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LNK3 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9555:ZDHHC2 ^@ http://purl.uniprot.org/uniprot/A0A096MZ13 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9555:EOMES ^@ http://purl.uniprot.org/uniprot/A0A096NDV4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9555:EIF4H ^@ http://purl.uniprot.org/uniprot/A0A096N2X1|||http://purl.uniprot.org/uniprot/A0A2I3NB98 ^@ Function|||Subcellular Location Annotation ^@ Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.|||perinuclear region http://togogenome.org/gene/9555:TGFB1 ^@ http://purl.uniprot.org/uniprot/A0A0A0MUY3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.|||extracellular matrix http://togogenome.org/gene/9555:TGM2 ^@ http://purl.uniprot.org/uniprot/A0A096NXG3 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9555:SLITRK4 ^@ http://purl.uniprot.org/uniprot/A0A096MW92 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9555:HRK ^@ http://purl.uniprot.org/uniprot/A0A096N944 ^@ Function|||Subcellular Location Annotation ^@ Mitochondrion|||Promotes apoptosis. http://togogenome.org/gene/9555:SDHAF4 ^@ http://purl.uniprot.org/uniprot/A0A096NW41 ^@ Similarity ^@ Belongs to the SDHAF4 family. http://togogenome.org/gene/9555:RAB14 ^@ http://purl.uniprot.org/uniprot/A0A096P0P9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Recycling endosome|||phagosome|||trans-Golgi network membrane http://togogenome.org/gene/9555:FASLG ^@ http://purl.uniprot.org/uniprot/A0A2I3MI81 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tumor necrosis factor family.|||Cell membrane|||Cytoplasmic form induces gene transcription inhibition.|||Cytoplasmic vesicle lumen|||Lysosome lumen|||Nucleus|||Secreted http://togogenome.org/gene/9555:PDRG1 ^@ http://purl.uniprot.org/uniprot/A0A096NUZ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.|||Cytoplasm|||May play a role in chaperone-mediated protein folding. http://togogenome.org/gene/9555:TIPRL ^@ http://purl.uniprot.org/uniprot/A0A096N0J9 ^@ Similarity ^@ Belongs to the TIP41 family. http://togogenome.org/gene/9555:GLB1L ^@ http://purl.uniprot.org/uniprot/A0A096MV68 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 35 family. http://togogenome.org/gene/9555:FTHL17 ^@ http://purl.uniprot.org/uniprot/A0A2I3LIN7 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/9555:CTU1 ^@ http://purl.uniprot.org/uniprot/A0A0A0MXD0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.|||Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3. May form a heterodimer with CTU2/NCS2.|||Cytoplasm|||Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. http://togogenome.org/gene/9555:UBE2E3 ^@ http://purl.uniprot.org/uniprot/A0A096MYK6 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9555:SGSH ^@ http://purl.uniprot.org/uniprot/A0A096NTB4 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9555:VTI1A ^@ http://purl.uniprot.org/uniprot/A0A2I3LDN3|||http://purl.uniprot.org/uniprot/A0A2I3LJT0|||http://purl.uniprot.org/uniprot/A0A8I5NI15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/9555:NDUFS2 ^@ http://purl.uniprot.org/uniprot/A0A096NQK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I 49 kDa subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:KREMEN2 ^@ http://purl.uniprot.org/uniprot/A0A096NL87|||http://purl.uniprot.org/uniprot/A0A2I3MFA6 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. http://togogenome.org/gene/9555:ERAP1 ^@ http://purl.uniprot.org/uniprot/A0A096MVZ0 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9555:TRIM72 ^@ http://purl.uniprot.org/uniprot/A0A096NHY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:ELF4 ^@ http://purl.uniprot.org/uniprot/A0A2I3MEQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9555:ZNF500 ^@ http://purl.uniprot.org/uniprot/A0A096NLG7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:SART1 ^@ http://purl.uniprot.org/uniprot/A0A096MRI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNU66/SART1 family.|||Nucleus http://togogenome.org/gene/9555:CTNNAL1 ^@ http://purl.uniprot.org/uniprot/A0A096P0X9 ^@ Similarity ^@ Belongs to the vinculin/alpha-catenin family. http://togogenome.org/gene/9555:NDUFV2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LYU0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. http://togogenome.org/gene/9555:LOC108586913 ^@ http://purl.uniprot.org/uniprot/A0A096MSB1 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion membrane http://togogenome.org/gene/9555:GPX5 ^@ http://purl.uniprot.org/uniprot/A0A096NLL5 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/9555:ADGRG6 ^@ http://purl.uniprot.org/uniprot/A0A096NGW1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:CDC37L1 ^@ http://purl.uniprot.org/uniprot/A0A096P1M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC37 family.|||Cytoplasm http://togogenome.org/gene/9555:LOC101016032 ^@ http://purl.uniprot.org/uniprot/A0A096P5W4 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily. http://togogenome.org/gene/9555:NIPAL1 ^@ http://purl.uniprot.org/uniprot/A0A096MV75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9555:SSR3 ^@ http://purl.uniprot.org/uniprot/A0A096NA71 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-gamma family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/9555:LLGL2 ^@ http://purl.uniprot.org/uniprot/A0A096NSW1|||http://purl.uniprot.org/uniprot/A0A2I3LQV5 ^@ Similarity ^@ Belongs to the WD repeat L(2)GL family. http://togogenome.org/gene/9555:LOC101022282 ^@ http://purl.uniprot.org/uniprot/A0A096P1U3 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/9555:GLB1L3 ^@ http://purl.uniprot.org/uniprot/A0A096N0U7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 35 family. http://togogenome.org/gene/9555:CERT1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LCQ5 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum|||Golgi apparatus http://togogenome.org/gene/9555:GPD2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NQ91 ^@ Function|||Similarity ^@ Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.|||Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device. http://togogenome.org/gene/9555:RGMA ^@ http://purl.uniprot.org/uniprot/A0A096NNB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the repulsive guidance molecule (RGM) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:UBE2D4 ^@ http://purl.uniprot.org/uniprot/A0A096N2Q2 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9555:MEA1 ^@ http://purl.uniprot.org/uniprot/A0A096NI86|||http://purl.uniprot.org/uniprot/A0A8I5N1T4|||http://purl.uniprot.org/uniprot/A0A8I5NGB5 ^@ Function ^@ May play an important role in spermatogenesis and/or testis development. http://togogenome.org/gene/9555:MOG ^@ http://purl.uniprot.org/uniprot/A0A2I3NFI8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Homodimer.|||Membrane|||Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion. http://togogenome.org/gene/9555:HK1 ^@ http://purl.uniprot.org/uniprot/A0A096P4Z4|||http://purl.uniprot.org/uniprot/A0A8I5P3E1 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/9555:RORC ^@ http://purl.uniprot.org/uniprot/A0A096MPI9|||http://purl.uniprot.org/uniprot/A0A2I3N556 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9555:PRDM4 ^@ http://purl.uniprot.org/uniprot/A0A096N6L6 ^@ Function|||Subcellular Location Annotation ^@ May function as a transcription factor involved in cell differentiation.|||Nucleus http://togogenome.org/gene/9555:MAPK10 ^@ http://purl.uniprot.org/uniprot/A0A2I3MKV8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/9555:CRYBA2 ^@ http://purl.uniprot.org/uniprot/A0A096MR79 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9555:C5H5orf63 ^@ http://purl.uniprot.org/uniprot/A0A2I3LDN0 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/9555:S100A6 ^@ http://purl.uniprot.org/uniprot/A0A096N997 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the S-100 family.|||May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.|||Nucleus envelope http://togogenome.org/gene/9555:RRAGA ^@ http://purl.uniprot.org/uniprot/A0A096NYK5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/9555:LOC101024056 ^@ http://purl.uniprot.org/uniprot/A0A096NFZ7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:LOC101023703 ^@ http://purl.uniprot.org/uniprot/A0A8I5NAJ6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:TSPYL6 ^@ http://purl.uniprot.org/uniprot/A0A8I5R062 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9555:ACKR4 ^@ http://purl.uniprot.org/uniprot/A0A096ND06 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9555:GLRB ^@ http://purl.uniprot.org/uniprot/A0A096MPS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane http://togogenome.org/gene/9555:SRRT ^@ http://purl.uniprot.org/uniprot/A0A096NGW3 ^@ Similarity ^@ Belongs to the ARS2 family. http://togogenome.org/gene/9555:VEGFD ^@ http://purl.uniprot.org/uniprot/A0A096N170 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDGF/VEGF growth factor family.|||Secreted http://togogenome.org/gene/9555:EZH2 ^@ http://purl.uniprot.org/uniprot/A0A2I3N7U4|||http://purl.uniprot.org/uniprot/A0A8I5N7G0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:ZHX3 ^@ http://purl.uniprot.org/uniprot/A0A2I3M573|||http://purl.uniprot.org/uniprot/A0A2I3M6Z9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZHX family.|||Nucleus http://togogenome.org/gene/9555:CA8 ^@ http://purl.uniprot.org/uniprot/A0A096MSS8 ^@ Similarity ^@ Belongs to the alpha-carbonic anhydrase family. http://togogenome.org/gene/9555:MMP20 ^@ http://purl.uniprot.org/uniprot/A0A096NXU1 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9555:PTPN1 ^@ http://purl.uniprot.org/uniprot/A0A096NNQ0 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. http://togogenome.org/gene/9555:TATDN3 ^@ http://purl.uniprot.org/uniprot/A0A2I3N9I4 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. http://togogenome.org/gene/9555:E2F6 ^@ http://purl.uniprot.org/uniprot/A0A8I5N9R7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9555:CASTOR2 ^@ http://purl.uniprot.org/uniprot/A0A096MWE8 ^@ Similarity ^@ Belongs to the GATS family. http://togogenome.org/gene/9555:TAF10 ^@ http://purl.uniprot.org/uniprot/A0A096MUB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF10 family.|||Nucleus|||The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. http://togogenome.org/gene/9555:MSRB3 ^@ http://purl.uniprot.org/uniprot/A0A096NBX4|||http://purl.uniprot.org/uniprot/A0A2I3N9Y8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Binds 1 zinc ion per subunit.|||Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. http://togogenome.org/gene/9555:NKX3-1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MAN9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:ZNF703 ^@ http://purl.uniprot.org/uniprot/A0A096MYN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Elbow/Noc family.|||Nucleus http://togogenome.org/gene/9555:LOC108586323 ^@ http://purl.uniprot.org/uniprot/A0A096N461 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/9555:SERPINA12 ^@ http://purl.uniprot.org/uniprot/A0A096NJJ6 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9555:CBX4 ^@ http://purl.uniprot.org/uniprot/A0A8I5NAF3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:ZFP36 ^@ http://purl.uniprot.org/uniprot/A0A8I5N4P0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.|||Cytoplasm|||Nucleus|||Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. http://togogenome.org/gene/9555:NR1I3 ^@ http://purl.uniprot.org/uniprot/A0A096N2Y4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9555:LBH ^@ http://purl.uniprot.org/uniprot/A0A096N1V2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LBH family.|||Cytoplasm|||Nucleus|||Transcriptional activator. http://togogenome.org/gene/9555:ATP8B2 ^@ http://purl.uniprot.org/uniprot/A0A096MTY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9555:A4GALT ^@ http://purl.uniprot.org/uniprot/A0A096N8Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 32 family.|||Golgi apparatus membrane http://togogenome.org/gene/9555:MC4R ^@ http://purl.uniprot.org/uniprot/A0A096ML25 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). http://togogenome.org/gene/9555:RAPSN ^@ http://purl.uniprot.org/uniprot/A0A096N391 ^@ Similarity ^@ Belongs to the RAPsyn family. http://togogenome.org/gene/9555:ATP5MG ^@ http://purl.uniprot.org/uniprot/A0A096MRD3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase g subunit family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion http://togogenome.org/gene/9555:INSIG2 ^@ http://purl.uniprot.org/uniprot/A9RA88 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the INSIG family.|||Binds oxysterols in a pocket within their transmembrane domains and interacts with SCAP via transmembrane domains 3 and 4.|||Endoplasmic reticulum membrane|||Interacts with SCAP; interaction is direct and only takes place in the presence of sterols; it prevents interaction between SCAP and the coat protein complex II (COPII). Associates with the SCAP-SREBP complex (composed of SCAP and SREBF1/SREBP1 or SREBF2/SREBP2); association is mediated via its interaction with SCAP and only takes place in the presence of sterols. Interacts with RNF139. Interacts with RNF145.|||Oxidized at Cys-215 in differentiated myotubes, preventing ubiquitination at the same site, and resulting in protein stabilization.|||Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR. Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum. In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi. Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG2 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2. Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase RNF139.|||Phosphorylation at Ser-151 by PCK1 reduces binding to oxysterol, disrupting the interaction between INSIG2 and SCAP, thereby promoting nuclear translocation of SREBP proteins (SREBF1/SREBP1 or SREBF2/SREBP2) and subsequent transcription of downstream lipogenesis-related genes.|||Polyubiquitinated by AMFR/gp78 at Cys-215 in some tissues such as adipose tissues, undifferentiated myoblasts and liver, leading to its degradation. In differentiated myotubes, Cys-215 oxidation prevents ubiquitination at the same site, resulting in protein stabilization.|||The KxHxx motif mediates association with the coatomer complex. http://togogenome.org/gene/9555:TMED3 ^@ http://purl.uniprot.org/uniprot/A0A096NMX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9555:ABLIM3 ^@ http://purl.uniprot.org/uniprot/A0A2I3LK69 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:BAP1 ^@ http://purl.uniprot.org/uniprot/A0A096N2N6 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/9555:FAM83C ^@ http://purl.uniprot.org/uniprot/A0A096NUP9 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9555:PLA2G12A ^@ http://purl.uniprot.org/uniprot/A0A096MLU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Secreted http://togogenome.org/gene/9555:FAM131A ^@ http://purl.uniprot.org/uniprot/A0A096N725 ^@ Similarity ^@ Belongs to the FAM131 family. http://togogenome.org/gene/9555:OLR120 ^@ http://purl.uniprot.org/uniprot/A9L8X2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:SLC25A31 ^@ http://purl.uniprot.org/uniprot/A0A096MUY6|||http://purl.uniprot.org/uniprot/A0A8I5QZZ1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/9555:PPM1G ^@ http://purl.uniprot.org/uniprot/A0A096NQ30 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9555:ZNF446 ^@ http://purl.uniprot.org/uniprot/A0A0A0MVJ0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:NMNAT2 ^@ http://purl.uniprot.org/uniprot/A0A096NQK4|||http://purl.uniprot.org/uniprot/A0A2I3NCD3 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/9555:SLFN11 ^@ http://purl.uniprot.org/uniprot/A0A1L3HEG3 ^@ Similarity ^@ Belongs to the Schlafen family. Subgroup III subfamily. http://togogenome.org/gene/9555:DMRT2 ^@ http://purl.uniprot.org/uniprot/A0A2I3NBM4|||http://purl.uniprot.org/uniprot/A0A8I5NW19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/9555:TMEM38B ^@ http://purl.uniprot.org/uniprot/A0A096P0Y7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM38 family.|||Membrane|||Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. http://togogenome.org/gene/9555:YWHAB ^@ http://purl.uniprot.org/uniprot/A0A096NX85 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9555:CORT ^@ http://purl.uniprot.org/uniprot/A0A2I3MPF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatostatin family.|||Secreted http://togogenome.org/gene/9555:MTERF2 ^@ http://purl.uniprot.org/uniprot/A0A096N6D9 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/9555:LOC101004536 ^@ http://purl.uniprot.org/uniprot/A0A8I5NTL9 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:TDRD3 ^@ http://purl.uniprot.org/uniprot/A0A2I3N9R7|||http://purl.uniprot.org/uniprot/A0A8I5NIV1|||http://purl.uniprot.org/uniprot/A0A8I5NJ32 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Nucleus|||Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1. http://togogenome.org/gene/9555:CEP57 ^@ http://purl.uniprot.org/uniprot/A0A2I3NDX7 ^@ Similarity ^@ Belongs to the translokin family. http://togogenome.org/gene/9555:TMEM70 ^@ http://purl.uniprot.org/uniprot/A0A8I5NHM4 ^@ Similarity ^@ Belongs to the TMEM70 family. http://togogenome.org/gene/9555:ICAM2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MC57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. ICAM family.|||Membrane http://togogenome.org/gene/9555:LOC101021244 ^@ http://purl.uniprot.org/uniprot/A0A8I5N8Y1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9555:KCND3 ^@ http://purl.uniprot.org/uniprot/A0A096MKK4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||dendrite http://togogenome.org/gene/9555:SLC4A10 ^@ http://purl.uniprot.org/uniprot/A0A096NXL4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9555:CDH9 ^@ http://purl.uniprot.org/uniprot/A0A096MML6 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:SAP30L ^@ http://purl.uniprot.org/uniprot/A0A096MR33 ^@ Similarity ^@ Belongs to the SAP30 family. http://togogenome.org/gene/9555:TRMT61A ^@ http://purl.uniprot.org/uniprot/A0A096NJY7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.|||Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.|||Nucleus http://togogenome.org/gene/9555:LOC101007126 ^@ http://purl.uniprot.org/uniprot/A0A8I5N0F0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:KEAP1 ^@ http://purl.uniprot.org/uniprot/A0A0A0MWA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KEAP1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:MINDY3 ^@ http://purl.uniprot.org/uniprot/A0A8I5MZV4 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM188 subfamily.|||Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. http://togogenome.org/gene/9555:SLC25A28 ^@ http://purl.uniprot.org/uniprot/A0A2I3ND84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9555:KCTD4 ^@ http://purl.uniprot.org/uniprot/A0A096MMQ1 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9555:NOSIP ^@ http://purl.uniprot.org/uniprot/A0A0A0MVU3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOSIP family.|||Cytoplasm|||Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.|||Nucleus http://togogenome.org/gene/9555:NIP7 ^@ http://purl.uniprot.org/uniprot/A0A2I3LSW5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NIP7 family.|||Interacts with pre-ribosome complex.|||Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.|||nucleolus http://togogenome.org/gene/9555:RAD23B ^@ http://purl.uniprot.org/uniprot/A0A096P0Y4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAD23 family.|||Cytoplasm|||Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.|||Nucleus http://togogenome.org/gene/9555:STAT3 ^@ http://purl.uniprot.org/uniprot/A0A096P5S8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:AKR1A1 ^@ http://purl.uniprot.org/uniprot/A0A096N138|||http://purl.uniprot.org/uniprot/A0A2I3NFW2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the aldo/keto reductase family.|||Cell membrane|||Membrane|||Monomer.|||cytosol http://togogenome.org/gene/9555:SPC24 ^@ http://purl.uniprot.org/uniprot/A0A0A0MUP7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the SPC24 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/9555:TMEM150B ^@ http://purl.uniprot.org/uniprot/A0A8I5N9R6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:LTF ^@ http://purl.uniprot.org/uniprot/A0A096MZN6|||http://purl.uniprot.org/uniprot/A0A8I5NGE3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transferrin family.|||Cytoplasmic granule|||Secreted|||Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. http://togogenome.org/gene/9555:UCMA ^@ http://purl.uniprot.org/uniprot/A0A2I3MW36 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UCMA family.|||May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.|||extracellular matrix http://togogenome.org/gene/9555:LOC101021626 ^@ http://purl.uniprot.org/uniprot/A0A8I5QZ98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:EMC9 ^@ http://purl.uniprot.org/uniprot/A0A096NX73 ^@ Similarity ^@ Belongs to the EMC8/EMC9 family. http://togogenome.org/gene/9555:CIAPIN1 ^@ http://purl.uniprot.org/uniprot/A0A096NIS3 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the anamorsin family.|||Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion intermembrane space|||Monomer. Interacts with NDOR1. Interacts with CHCHD4.|||Nucleus|||The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.|||The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.|||The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space. http://togogenome.org/gene/9555:OTUB1 ^@ http://purl.uniprot.org/uniprot/A0A2I3M9H8 ^@ Similarity ^@ Belongs to the peptidase C65 family. http://togogenome.org/gene/9555:OPRL1 ^@ http://purl.uniprot.org/uniprot/A0A8I5N3E0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasmic vesicle|||G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.|||Membrane|||Vesicle http://togogenome.org/gene/9555:CLDN11 ^@ http://purl.uniprot.org/uniprot/A0A8I5NFZ2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9555:SCML4 ^@ http://purl.uniprot.org/uniprot/A0A096NR75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCM family.|||Nucleus http://togogenome.org/gene/9555:KCNV1 ^@ http://purl.uniprot.org/uniprot/A0A096N5E8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.|||Cell membrane|||Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.|||Membrane|||Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes. http://togogenome.org/gene/9555:AJAP1 ^@ http://purl.uniprot.org/uniprot/A0A096MLE5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:ST6GALNAC6 ^@ http://purl.uniprot.org/uniprot/A0A096P1Z4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9555:NDST1 ^@ http://purl.uniprot.org/uniprot/A0A8I5N368 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/9555:SEC24D ^@ http://purl.uniprot.org/uniprot/A0A096MXK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9555:RELT ^@ http://purl.uniprot.org/uniprot/A0A096MY58 ^@ Similarity ^@ Belongs to the RELT family. http://togogenome.org/gene/9555:ZC3H14 ^@ http://purl.uniprot.org/uniprot/A0A096NW64|||http://purl.uniprot.org/uniprot/A0A096NW67|||http://purl.uniprot.org/uniprot/A0A2I3LWL0|||http://purl.uniprot.org/uniprot/A0A2I3MTZ0|||http://purl.uniprot.org/uniprot/A0A8I5R6M3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZC3H14 family.|||Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.|||Nucleus speckle http://togogenome.org/gene/9555:TAF9 ^@ http://purl.uniprot.org/uniprot/A0A8I5NA99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF9 family.|||Nucleus http://togogenome.org/gene/9555:NACC2 ^@ http://purl.uniprot.org/uniprot/A0A096NRT7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:AK1 ^@ http://purl.uniprot.org/uniprot/A0A096P1Z5|||http://purl.uniprot.org/uniprot/A0A2I3MCP8 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK1 subfamily.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/9555:ACTL6B ^@ http://purl.uniprot.org/uniprot/A0A096P0C3 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9555:ZSCAN20 ^@ http://purl.uniprot.org/uniprot/A0A096MUB0|||http://purl.uniprot.org/uniprot/A0A2I3MIP6 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9555:PLSCR4 ^@ http://purl.uniprot.org/uniprot/A0A096P027 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/9555:TCTN2 ^@ http://purl.uniprot.org/uniprot/A0A096MQR2 ^@ Similarity|||Subunit ^@ Belongs to the tectonic family.|||Part of the tectonic-like complex (also named B9 complex). http://togogenome.org/gene/9555:VOPP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3NDN0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VOPP1/ECOP family.|||Cytoplasmic vesicle membrane|||Endosome membrane|||Interacts with WWOX (via WW domain).|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9555:SIVA1 ^@ http://purl.uniprot.org/uniprot/A0A096NK31 ^@ Function|||PTM|||Subcellular Location Annotation ^@ Cytoplasm|||Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.|||Nucleus|||Phosphorylated by ABL2/ARG in response to oxidative stress. http://togogenome.org/gene/9555:APH1B ^@ http://purl.uniprot.org/uniprot/A0A096NMA3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the APH-1 family.|||Component of the gamma-secretase complex.|||Membrane|||Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. http://togogenome.org/gene/9555:ATP6V1G3 ^@ http://purl.uniprot.org/uniprot/A0A096NC85 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9555:SMPD1 ^@ http://purl.uniprot.org/uniprot/A0A096MN10 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acid sphingomyelinase family.|||Binds 2 Zn(2+) ions per subunit.|||Converts sphingomyelin to ceramide.|||Secreted http://togogenome.org/gene/9555:OGDHL ^@ http://purl.uniprot.org/uniprot/A0A2I3LSI8|||http://purl.uniprot.org/uniprot/A0A2I3MP74|||http://purl.uniprot.org/uniprot/A0A2I3MQ00 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/9555:CDK20 ^@ http://purl.uniprot.org/uniprot/A0A2I3MEM2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:CNOT11 ^@ http://purl.uniprot.org/uniprot/A0A2I3N1D3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT11 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:KCNJ1 ^@ http://purl.uniprot.org/uniprot/A0A096N8F3|||http://purl.uniprot.org/uniprot/A0A096NPB9|||http://purl.uniprot.org/uniprot/A0A2I3LMK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9555:LOC101026809 ^@ http://purl.uniprot.org/uniprot/A0A8I5NJ97 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIII family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:CALCRL ^@ http://purl.uniprot.org/uniprot/A0A096MW59 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.|||Membrane|||Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. http://togogenome.org/gene/9555:SERINC1 ^@ http://purl.uniprot.org/uniprot/A0A096N5A6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9555:GATA3 ^@ http://purl.uniprot.org/uniprot/A0A096P3E2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:DENND10 ^@ http://purl.uniprot.org/uniprot/A0A096NTX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DENND10 family.|||Endosome|||Late endosome http://togogenome.org/gene/9555:KCNH8 ^@ http://purl.uniprot.org/uniprot/A0A2I3N284 ^@ Subcellular Location Annotation|||Subunit ^@ Membrane|||The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. http://togogenome.org/gene/9555:HOXA11 ^@ http://purl.uniprot.org/uniprot/A9L944 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9555:CTPS1 ^@ http://purl.uniprot.org/uniprot/A0A096MT53 ^@ Function|||Similarity ^@ Belongs to the CTP synthase family.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. http://togogenome.org/gene/9555:FGFR2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LY86|||http://purl.uniprot.org/uniprot/A0A2I3NGK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:PLP1 ^@ http://purl.uniprot.org/uniprot/A0A096NXY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/9555:SUMF1 ^@ http://purl.uniprot.org/uniprot/A0A096N097 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase-modifying factor family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9555:ANXA13 ^@ http://purl.uniprot.org/uniprot/A0A096N2Z4|||http://purl.uniprot.org/uniprot/A0A2I3MKG4 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9555:NKX1-2 ^@ http://purl.uniprot.org/uniprot/A0A096NU56 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:UVSSA ^@ http://purl.uniprot.org/uniprot/A0A096MN70 ^@ Similarity ^@ Belongs to the UVSSA family. http://togogenome.org/gene/9555:RAB3IL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MNI8 ^@ Similarity ^@ Belongs to the SEC2 family. http://togogenome.org/gene/9555:GATC ^@ http://purl.uniprot.org/uniprot/A0A2I3LU17 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/9555:KCNA4 ^@ http://purl.uniprot.org/uniprot/A0A8I5NUU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily.|||Cell membrane|||Membrane|||axon http://togogenome.org/gene/9555:POMGNT2 ^@ http://purl.uniprot.org/uniprot/A0A096NCA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 61 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:RYBP ^@ http://purl.uniprot.org/uniprot/A0A8I5NQY9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:GPLD1 ^@ http://purl.uniprot.org/uniprot/A0A096NLB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GPLD1 family.|||Secreted http://togogenome.org/gene/9555:SLC25A20 ^@ http://purl.uniprot.org/uniprot/A0A096NF18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9555:C5H5orf22 ^@ http://purl.uniprot.org/uniprot/A0A096N4A5 ^@ Similarity ^@ Belongs to the UPF0489 family. http://togogenome.org/gene/9555:TRUB2 ^@ http://purl.uniprot.org/uniprot/A0A096P0L4 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/9555:CCL18 ^@ http://purl.uniprot.org/uniprot/A0A8I5MUX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9555:ASTL ^@ http://purl.uniprot.org/uniprot/A0A096NWF9 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:EFNA4 ^@ http://purl.uniprot.org/uniprot/A0A2I3MFE6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:STAR ^@ http://purl.uniprot.org/uniprot/A0A096N0P1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ May interact with TSPO.|||Mitochondrion|||Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. http://togogenome.org/gene/9555:UBE2T ^@ http://purl.uniprot.org/uniprot/A0A096NB93 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9555:TFAP2B ^@ http://purl.uniprot.org/uniprot/A0A2I3LQ56 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/9555:PROK2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LKN9|||http://purl.uniprot.org/uniprot/A0A2I3NFK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AVIT (prokineticin) family.|||Secreted http://togogenome.org/gene/9555:PSMD7 ^@ http://purl.uniprot.org/uniprot/A0A096MWU8 ^@ Similarity ^@ Belongs to the peptidase M67A family. http://togogenome.org/gene/9555:LAMTOR3 ^@ http://purl.uniprot.org/uniprot/A0A096MRX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR3 family.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/9555:GRID2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LQV6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/9555:CABP7 ^@ http://purl.uniprot.org/uniprot/Q866X0 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Interacts with PI4KB. This binding competes with FREQ/NCS1 binding in a calcium-dependent manner (By similarity).|||Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity.|||The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting.|||perinuclear region|||trans-Golgi network membrane http://togogenome.org/gene/9555:ART4 ^@ http://purl.uniprot.org/uniprot/A0A096MVI2 ^@ Similarity ^@ Belongs to the Arg-specific ADP-ribosyltransferase family. http://togogenome.org/gene/9555:PEX5 ^@ http://purl.uniprot.org/uniprot/A0A2I3LZW1 ^@ Similarity ^@ Belongs to the peroxisomal targeting signal receptor family. http://togogenome.org/gene/9555:TNPO2 ^@ http://purl.uniprot.org/uniprot/A0A0A0MW54 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:SELENOI ^@ http://purl.uniprot.org/uniprot/A0A8I5NU95 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/9555:YJU2 ^@ http://purl.uniprot.org/uniprot/A0A0A0MUA6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CWC16 family. YJU2 subfamily.|||Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.|||Nucleus|||Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex. http://togogenome.org/gene/9555:KDELR1 ^@ http://purl.uniprot.org/uniprot/A0A0A0MWV2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:STX1B ^@ http://purl.uniprot.org/uniprot/A0A096NHX1 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9555:PXN ^@ http://purl.uniprot.org/uniprot/A0A096MMZ1|||http://purl.uniprot.org/uniprot/A0A2I3MMR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paxillin family.|||cell cortex|||cytoskeleton|||focal adhesion http://togogenome.org/gene/9555:CCT8L2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NVN5 ^@ Function|||Similarity ^@ Belongs to the TCP-1 chaperonin family.|||Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. http://togogenome.org/gene/9555:ITGB8 ^@ http://purl.uniprot.org/uniprot/A0A2I3N5C7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:ALDH2 ^@ http://purl.uniprot.org/uniprot/A0A096N8X2 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9555:LOC101008565 ^@ http://purl.uniprot.org/uniprot/A0A096NGT8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily. http://togogenome.org/gene/9555:CCDC58 ^@ http://purl.uniprot.org/uniprot/A0A096NEY7|||http://purl.uniprot.org/uniprot/A0A2I3M8Y2 ^@ Similarity ^@ Belongs to the MIX23 family. http://togogenome.org/gene/9555:ENO3 ^@ http://purl.uniprot.org/uniprot/A0A096P2I8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/9555:LANCL2 ^@ http://purl.uniprot.org/uniprot/A0A096NW13 ^@ Similarity ^@ Belongs to the LanC-like protein family. http://togogenome.org/gene/9555:GATA4 ^@ http://purl.uniprot.org/uniprot/A0A2I3MF62 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:RAD50 ^@ http://purl.uniprot.org/uniprot/A9CB11 ^@ Similarity ^@ Belongs to the SMC family. RAD50 subfamily. http://togogenome.org/gene/9555:ACHE ^@ http://purl.uniprot.org/uniprot/A0A2I3M3A8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Secreted http://togogenome.org/gene/9555:CACNG1 ^@ http://purl.uniprot.org/uniprot/A0A096NTY2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.|||Membrane|||Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.|||sarcolemma http://togogenome.org/gene/9555:ELF2 ^@ http://purl.uniprot.org/uniprot/A0A096N3F0|||http://purl.uniprot.org/uniprot/A0A2I3N8D4|||http://purl.uniprot.org/uniprot/A0A8I5N2T7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9555:SNCA ^@ http://purl.uniprot.org/uniprot/A0A2I3NA67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synuclein family.|||Membrane|||Nucleus|||Secreted|||Synapse|||axon http://togogenome.org/gene/9555:NUMB ^@ http://purl.uniprot.org/uniprot/A0A096NVZ0|||http://purl.uniprot.org/uniprot/A0A2I3LMU2|||http://purl.uniprot.org/uniprot/A0A2I3MUA0 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Plays a role in the process of neurogenesis. http://togogenome.org/gene/9555:MTIF2 ^@ http://purl.uniprot.org/uniprot/A0A096NGV9 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/9555:NAPRT ^@ http://purl.uniprot.org/uniprot/A0A096NWT1 ^@ Function|||PTM|||Similarity ^@ Belongs to the NAPRTase family.|||Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.|||Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. http://togogenome.org/gene/9555:SLC10A7 ^@ http://purl.uniprot.org/uniprot/A0A096N629|||http://purl.uniprot.org/uniprot/A0A2I3LHM4|||http://purl.uniprot.org/uniprot/A0A2I3NCP3|||http://purl.uniprot.org/uniprot/A0A8I5P0A6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Cell membrane|||Does not show transport activity towards bile acids or steroid sulfates.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane http://togogenome.org/gene/9555:LOC100997529 ^@ http://purl.uniprot.org/uniprot/G4XXN9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space|||Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. http://togogenome.org/gene/9555:FAM166A ^@ http://purl.uniprot.org/uniprot/A0A096NWN3 ^@ Similarity ^@ Belongs to the CIMIP2 family. http://togogenome.org/gene/9555:S100A4 ^@ http://purl.uniprot.org/uniprot/A0A096NEN2 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9555:LMNB1 ^@ http://purl.uniprot.org/uniprot/A0A096MS49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intermediate filament family.|||Nucleus lamina http://togogenome.org/gene/9555:DSTN ^@ http://purl.uniprot.org/uniprot/A0A2I3LIX1 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. http://togogenome.org/gene/9555:GPR182 ^@ http://purl.uniprot.org/uniprot/A0A096MLZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:ACADS ^@ http://purl.uniprot.org/uniprot/A0A096N9P5 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9555:LRP5 ^@ http://purl.uniprot.org/uniprot/B5TRI1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LDLR family.|||Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes.|||Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:NTSR1 ^@ http://purl.uniprot.org/uniprot/A0A096NNA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:KCNV2 ^@ http://purl.uniprot.org/uniprot/A0A096P1N4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9555:CPVL ^@ http://purl.uniprot.org/uniprot/A0A096MQ70 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/9555:LOC101021003 ^@ http://purl.uniprot.org/uniprot/A0A096MZA0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:LYZ ^@ http://purl.uniprot.org/uniprot/P61629 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 22 family.|||Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.|||Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.|||Monomer.|||Secreted http://togogenome.org/gene/9555:CITED1 ^@ http://purl.uniprot.org/uniprot/A0A8I5R0M3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CITED family.|||Nucleus http://togogenome.org/gene/9555:TEKT4 ^@ http://purl.uniprot.org/uniprot/A0A096P258 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/9555:RNF121 ^@ http://purl.uniprot.org/uniprot/A0A096MMB2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:PAQR4 ^@ http://purl.uniprot.org/uniprot/A0A096NL92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9555:ABCC4 ^@ http://purl.uniprot.org/uniprot/A0A096MWK8|||http://purl.uniprot.org/uniprot/A0A8I5NPN6|||http://purl.uniprot.org/uniprot/A0A8I5R1Y5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:NIBAN2 ^@ http://purl.uniprot.org/uniprot/A0A096P204 ^@ Similarity ^@ Belongs to the Niban family. http://togogenome.org/gene/9555:GTDC1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LWK0 ^@ Similarity ^@ Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. http://togogenome.org/gene/9555:GPN1 ^@ http://purl.uniprot.org/uniprot/A0A096P001 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II.|||Cytoplasm|||Nucleus|||Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/9555:GABARAPL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LIX7 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9555:PSMA7 ^@ http://purl.uniprot.org/uniprot/A0A096NND3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9555:JPT2 ^@ http://purl.uniprot.org/uniprot/A0A096NKT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:LTV1 ^@ http://purl.uniprot.org/uniprot/A0A096N3Y7 ^@ Similarity ^@ Belongs to the LTV1 family. http://togogenome.org/gene/9555:ENPP1 ^@ http://purl.uniprot.org/uniprot/A9X179 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.|||Secreted http://togogenome.org/gene/9555:SNRPN ^@ http://purl.uniprot.org/uniprot/A0A2I3MWW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP SmB/SmN family.|||Nucleus http://togogenome.org/gene/9555:LOC101017813 ^@ http://purl.uniprot.org/uniprot/A0A8I5NQG3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:CCDC167 ^@ http://purl.uniprot.org/uniprot/A0A096NHV3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:PLK1 ^@ http://purl.uniprot.org/uniprot/A0A096NHF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.|||Midbody|||Nucleus|||centrosome http://togogenome.org/gene/9555:KRT20 ^@ http://purl.uniprot.org/uniprot/A0A096P5J1 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9555:PPP1R35 ^@ http://purl.uniprot.org/uniprot/A0A096N5S2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP1R35 family.|||centriole http://togogenome.org/gene/9555:CDC42EP2 ^@ http://purl.uniprot.org/uniprot/A0A096ML12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system|||Probably involved in the organization of the actin cytoskeleton.|||cytoskeleton http://togogenome.org/gene/9555:KRT71 ^@ http://purl.uniprot.org/uniprot/A0A096N7Y8 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9555:NEFL ^@ http://purl.uniprot.org/uniprot/A0A096NG79 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9555:IQCG ^@ http://purl.uniprot.org/uniprot/A0A096P1C4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC9 family.|||flagellum|||flagellum axoneme http://togogenome.org/gene/9555:PKP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LM88 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/9555:ADAMTS9 ^@ http://purl.uniprot.org/uniprot/A0A096NA48|||http://purl.uniprot.org/uniprot/A0A2I3MXS1 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9555:PEX14 ^@ http://purl.uniprot.org/uniprot/A0A096NQF4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-14 family.|||Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.|||Peroxisome membrane http://togogenome.org/gene/9555:WEE1 ^@ http://purl.uniprot.org/uniprot/A0A096MRA8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.|||Binds 2 magnesium ions per subunit.|||Nucleus http://togogenome.org/gene/9555:ZADH2 ^@ http://purl.uniprot.org/uniprot/A0A096NH16 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/9555:RSPO2 ^@ http://purl.uniprot.org/uniprot/A0A096NFK4|||http://purl.uniprot.org/uniprot/A0A8I5MZZ8 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/9555:MANEAL ^@ http://purl.uniprot.org/uniprot/A0A096NWC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 99 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9555:TRIM47 ^@ http://purl.uniprot.org/uniprot/A0A096NSZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Nucleus http://togogenome.org/gene/9555:COQ8B ^@ http://purl.uniprot.org/uniprot/A0A0A0MVT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family.|||Membrane http://togogenome.org/gene/9555:APH1A ^@ http://purl.uniprot.org/uniprot/A0A096N930 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the APH-1 family.|||Component of the gamma-secretase complex.|||Membrane|||Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. http://togogenome.org/gene/9555:LASP1 ^@ http://purl.uniprot.org/uniprot/A0A096P590|||http://purl.uniprot.org/uniprot/A0A2I3MMJ0 ^@ Function|||Subcellular Location Annotation ^@ Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.|||cell cortex|||cytoskeleton http://togogenome.org/gene/9555:NR4A2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MAU4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family.|||Cytoplasm|||Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.|||Nucleus http://togogenome.org/gene/9555:MOB1B ^@ http://purl.uniprot.org/uniprot/A0A2I3LVA5 ^@ Similarity ^@ Belongs to the MOB1/phocein family. http://togogenome.org/gene/9555:HSD17B4 ^@ http://purl.uniprot.org/uniprot/A0A096MSY0 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/9555:ACTR1A ^@ http://purl.uniprot.org/uniprot/A0A2I3LT44 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9555:GJD2 ^@ http://purl.uniprot.org/uniprot/A0A096NTA7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9555:B3GAT1 ^@ http://purl.uniprot.org/uniprot/A0A8I5ND89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9555:EML4 ^@ http://purl.uniprot.org/uniprot/A0A2I3MBM1|||http://purl.uniprot.org/uniprot/A0A8I5N2D5|||http://purl.uniprot.org/uniprot/A0A8I5RA19 ^@ Similarity ^@ Belongs to the WD repeat EMAP family. http://togogenome.org/gene/9555:HENMT1 ^@ http://purl.uniprot.org/uniprot/A0A096NPN5 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. HEN1 family. http://togogenome.org/gene/9555:CTBP1 ^@ http://purl.uniprot.org/uniprot/A0A096N3F3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Nucleus http://togogenome.org/gene/9555:F7 ^@ http://purl.uniprot.org/uniprot/A9X171 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9555:ODC1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NKM9 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/9555:TSPAN1 ^@ http://purl.uniprot.org/uniprot/A0A096N1N8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9555:EWSR1 ^@ http://purl.uniprot.org/uniprot/A0A096NJD3|||http://purl.uniprot.org/uniprot/A0A2I3MFP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TET family.|||Nucleus http://togogenome.org/gene/9555:STAM2 ^@ http://purl.uniprot.org/uniprot/A0A096NXW7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the STAM family.|||Early endosome membrane|||Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. http://togogenome.org/gene/9555:GPC5 ^@ http://purl.uniprot.org/uniprot/A0A096MYU5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/9555:LOC101003015 ^@ http://purl.uniprot.org/uniprot/A0A096P2Q7 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9555:FEN1 ^@ http://purl.uniprot.org/uniprot/A0A096NYK4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Mitochondrion|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9555:MPI ^@ http://purl.uniprot.org/uniprot/A0A096NMS2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the mannose-6-phosphate isomerase type 1 family.|||Binds 1 zinc ion per subunit.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/9555:PSMB2 ^@ http://purl.uniprot.org/uniprot/A0A096MX69 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:LOC101006708 ^@ http://purl.uniprot.org/uniprot/A0A096N8A7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:UBE2G1 ^@ http://purl.uniprot.org/uniprot/A0A096P2F5 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9555:CACNA1C ^@ http://purl.uniprot.org/uniprot/A0A2I3LLL6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily.|||Cell membrane|||Membrane|||Perikaryon|||Postsynaptic density membrane|||T-tubule|||Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.|||dendrite|||sarcolemma http://togogenome.org/gene/9555:TBC1D24 ^@ http://purl.uniprot.org/uniprot/A0A096NL62|||http://purl.uniprot.org/uniprot/A0A2I3M1U7 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasmic vesicle membrane|||Interacts with ARF6.|||Membrane|||Presynapse http://togogenome.org/gene/9555:NPC2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LDJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPC2 family.|||Secreted http://togogenome.org/gene/9555:DEFB116 ^@ http://purl.uniprot.org/uniprot/A0A096NV17 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9555:SMAD3 ^@ http://purl.uniprot.org/uniprot/A0A096NMF6|||http://purl.uniprot.org/uniprot/A0A8I5NQ42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:TIMM17B ^@ http://purl.uniprot.org/uniprot/A0A096MXT9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:ACTR3B ^@ http://purl.uniprot.org/uniprot/A0A2I3M7K2 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9555:SNCG ^@ http://purl.uniprot.org/uniprot/A0A096P4D2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the synuclein family.|||May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation.|||spindle http://togogenome.org/gene/9555:SSX2IP ^@ http://purl.uniprot.org/uniprot/A0A8I5N751 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIP family.|||adherens junction|||centriolar satellite http://togogenome.org/gene/9555:GPR65 ^@ http://purl.uniprot.org/uniprot/A0A2I3N193 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9555:TOR1B ^@ http://purl.uniprot.org/uniprot/A0A096P0H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ClpA/ClpB family. Torsin subfamily.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9555:ACTB ^@ http://purl.uniprot.org/uniprot/A0A096NAA6 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9555:ICAM5 ^@ http://purl.uniprot.org/uniprot/A0A0A0MUU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. ICAM family.|||Membrane http://togogenome.org/gene/9555:FAM122B ^@ http://purl.uniprot.org/uniprot/A0A096NCY8|||http://purl.uniprot.org/uniprot/A0A2I3MP79 ^@ Similarity ^@ Belongs to the FAM122 family. http://togogenome.org/gene/9555:NAA11 ^@ http://purl.uniprot.org/uniprot/A0A096MR92 ^@ Similarity ^@ Belongs to the acetyltransferase family. ARD1 subfamily. http://togogenome.org/gene/9555:LSM1 ^@ http://purl.uniprot.org/uniprot/A0A096NFU2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Cytoplasm|||Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.|||P-body|||Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. http://togogenome.org/gene/9555:LHX5 ^@ http://purl.uniprot.org/uniprot/A0A096N1Z4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:KMT5A ^@ http://purl.uniprot.org/uniprot/A0A096N875 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus http://togogenome.org/gene/9555:SPAG7 ^@ http://purl.uniprot.org/uniprot/A0A2I3LJY8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:LMOD1 ^@ http://purl.uniprot.org/uniprot/A0A096N290 ^@ Subcellular Location Annotation ^@ cytoskeleton|||sarcomere http://togogenome.org/gene/9555:VGLL3 ^@ http://purl.uniprot.org/uniprot/A0A096NWE3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs.|||Nucleus http://togogenome.org/gene/9555:LOC101024135 ^@ http://purl.uniprot.org/uniprot/A0A096MW83 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9555:CAV1 ^@ http://purl.uniprot.org/uniprot/A0M8R6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||Homooligomer. Interacts (via the N-terminus) with DPP4; the interaction is direct. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Interacts with PACSIN2; this interaction induces membrane tubulation (By similarity). Interacts with BMX, BTK, CTNNB1, CDH1, GLIPR2, JUP, NOSTRIN, SNAP25 and STX1A. Interacts with SLC7A9. Interacts with TGFBR1. Interacts with CAVIN3 (via leucine-zipper domain) in a cholesterol-sensitive manner. Interacts with CAVIN1. Interacts with EHD2 in a cholesterol-dependent manner. Forms a ternary complex with UBXN6 and VCP; mediates CAV1 targeting to lysosomes for degradation. Interacts with ABCG1; this interaction regulates ABCG1-mediated cholesterol efflux (By similarity). Interacts with NEU3; this interaction enhances NEU3 sialidase activity within caveola. Interacts (via C-terminus) with SPRY1, SPRY2 (via C-terminus), SPRY3, and SPRY4 (By similarity).|||May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity).|||Membrane raft|||Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.|||Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination. Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation. Ubiquitinated by ZNRF1; leading to degradation and modulation of the TLR4-mediated immune response.|||caveola http://togogenome.org/gene/9555:OLR145 ^@ http://purl.uniprot.org/uniprot/A9L8Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:HFE ^@ http://purl.uniprot.org/uniprot/A0A8I5NMF3 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9555:ASB11 ^@ http://purl.uniprot.org/uniprot/A0A2I3LU72|||http://purl.uniprot.org/uniprot/A0A8I5NX98 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9555:HADHA ^@ http://purl.uniprot.org/uniprot/A0A096NSI3 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9555:LDLRAD3 ^@ http://purl.uniprot.org/uniprot/A0A2I3LT76 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:NUDT4 ^@ http://purl.uniprot.org/uniprot/A0A096NC79 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DIPP subfamily. http://togogenome.org/gene/9555:TMEM251 ^@ http://purl.uniprot.org/uniprot/A0A096NJF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LYSET family.|||Membrane http://togogenome.org/gene/9555:SLC6A14 ^@ http://purl.uniprot.org/uniprot/A0A096MXM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9555:ENO2 ^@ http://purl.uniprot.org/uniprot/A0A096MTX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/9555:TSPAN4 ^@ http://purl.uniprot.org/uniprot/A0A096NYX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9555:SUSD6 ^@ http://purl.uniprot.org/uniprot/A0A096NVU4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:EIF2D ^@ http://purl.uniprot.org/uniprot/A0A096NF95 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF2D family.|||Cytoplasm|||Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. http://togogenome.org/gene/9555:LOC101002474 ^@ http://purl.uniprot.org/uniprot/A0A2I3MUE4 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9555:CLDN4 ^@ http://purl.uniprot.org/uniprot/A0A096MKU9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9555:RAP1GDS1 ^@ http://purl.uniprot.org/uniprot/A0A2I3N380|||http://purl.uniprot.org/uniprot/A0A2I3NGI3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum|||Mitochondrion http://togogenome.org/gene/9555:SLC45A3 ^@ http://purl.uniprot.org/uniprot/A0A096MUG2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:PPP1CC ^@ http://purl.uniprot.org/uniprot/A0A2I3NER2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family. PP-1 subfamily.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9555:GOLT1A ^@ http://purl.uniprot.org/uniprot/A0A096NB96 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||May be involved in fusion of ER-derived transport vesicles with the Golgi complex.|||Membrane http://togogenome.org/gene/9555:CCNE2 ^@ http://purl.uniprot.org/uniprot/A0A096MVM7 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9555:TGIF2 ^@ http://purl.uniprot.org/uniprot/A0A096NUK5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:TMEM151A ^@ http://purl.uniprot.org/uniprot/A0A096MT00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM151 family.|||Membrane http://togogenome.org/gene/9555:KCNJ5 ^@ http://purl.uniprot.org/uniprot/A0A096N0B8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.|||Membrane http://togogenome.org/gene/9555:CDH5 ^@ http://purl.uniprot.org/uniprot/A0A096NJ54 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:CCNB1 ^@ http://purl.uniprot.org/uniprot/A0A096NC02 ^@ Function|||Similarity ^@ Belongs to the cyclin family.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition. http://togogenome.org/gene/9555:SF3B4 ^@ http://purl.uniprot.org/uniprot/A0A096MR38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3B4 family.|||Nucleus http://togogenome.org/gene/9555:VPS45 ^@ http://purl.uniprot.org/uniprot/A0A8I5NZY9 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9555:A4GNT ^@ http://purl.uniprot.org/uniprot/A0A8I5NLB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 32 family.|||Golgi apparatus membrane http://togogenome.org/gene/9555:CP ^@ http://purl.uniprot.org/uniprot/A0A096NQN8|||http://purl.uniprot.org/uniprot/A0A2I3LSC7 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/9555:DPAGT1 ^@ http://purl.uniprot.org/uniprot/A0A096N3W2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family.|||Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:LYVE1 ^@ http://purl.uniprot.org/uniprot/A0A096MN11 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:XPNPEP2 ^@ http://purl.uniprot.org/uniprot/A0A096NC77 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/9555:HGS ^@ http://purl.uniprot.org/uniprot/A0A096NTH6 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Early endosome membrane|||Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.|||multivesicular body membrane http://togogenome.org/gene/9555:TPRA1 ^@ http://purl.uniprot.org/uniprot/A0A096NGA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0359 family.|||Membrane http://togogenome.org/gene/9555:SNX1 ^@ http://purl.uniprot.org/uniprot/A0A096NMB4|||http://purl.uniprot.org/uniprot/A0A2I3LW04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome membrane|||Endosome membrane|||Membrane|||lamellipodium|||trans-Golgi network membrane http://togogenome.org/gene/9555:IL22 ^@ http://purl.uniprot.org/uniprot/A0A096NE66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Secreted http://togogenome.org/gene/9555:SLC25A47 ^@ http://purl.uniprot.org/uniprot/A0A096NJR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9555:TP53I11 ^@ http://purl.uniprot.org/uniprot/A0A8I5N7I2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:CRYGN ^@ http://purl.uniprot.org/uniprot/A0A2I3N7G3 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9555:NCBP3 ^@ http://purl.uniprot.org/uniprot/A0A096P2E8 ^@ Similarity ^@ Belongs to the NCBP3 family. http://togogenome.org/gene/9555:DCTN2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LFZ8|||http://purl.uniprot.org/uniprot/A0A2I3LI75 ^@ Similarity ^@ Belongs to the dynactin subunit 2 family. http://togogenome.org/gene/9555:NUCB2 ^@ http://purl.uniprot.org/uniprot/A0A096N756 ^@ Similarity ^@ Belongs to the nucleobindin family. http://togogenome.org/gene/9555:ODR4 ^@ http://purl.uniprot.org/uniprot/A0A2I3NFP3 ^@ Function|||Similarity ^@ Belongs to the ODR-4 family.|||May play a role in the trafficking of a subset of G-protein coupled receptors. http://togogenome.org/gene/9555:ADGRG7 ^@ http://purl.uniprot.org/uniprot/A0A096NXS3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:MTERF1 ^@ http://purl.uniprot.org/uniprot/A0A096NZU0 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/9555:SLITRK1 ^@ http://purl.uniprot.org/uniprot/A0A096NXL6 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9555:MRPS10 ^@ http://purl.uniprot.org/uniprot/A0A096NI51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS10 family.|||Mitochondrion http://togogenome.org/gene/9555:SPTBN2 ^@ http://purl.uniprot.org/uniprot/A0A096MRI4 ^@ Similarity ^@ Belongs to the spectrin family. http://togogenome.org/gene/9555:LOXL1 ^@ http://purl.uniprot.org/uniprot/A0A096NMP3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/9555:USP13 ^@ http://purl.uniprot.org/uniprot/A0A096NXV0 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9555:DTX1 ^@ http://purl.uniprot.org/uniprot/A0A096MUP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Deltex family.|||Cytoplasm http://togogenome.org/gene/9555:LOC101014702 ^@ http://purl.uniprot.org/uniprot/A0A096N7S1 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS25 family.|||Component of the small ribosomal subunit. http://togogenome.org/gene/9555:MFSD4B ^@ http://purl.uniprot.org/uniprot/A0A8I5NYV5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:PSMA3 ^@ http://purl.uniprot.org/uniprot/A0A2I3LV86 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9555:MAP2K4 ^@ http://purl.uniprot.org/uniprot/A0A2I3LK59 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:TMEM163 ^@ http://purl.uniprot.org/uniprot/A0A096NDI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM163 family.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/9555:GSKIP ^@ http://purl.uniprot.org/uniprot/A0A096NJN1 ^@ Similarity ^@ Belongs to the GSKIP family. http://togogenome.org/gene/9555:PPP2R5A ^@ http://purl.uniprot.org/uniprot/A0A8I5N6U2 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9555:CPB1 ^@ http://purl.uniprot.org/uniprot/A0A096NP95 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9555:TSSK6 ^@ http://purl.uniprot.org/uniprot/A0A0A0MVT0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:SLC16A10 ^@ http://purl.uniprot.org/uniprot/A0A096MVJ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:RPL10 ^@ http://purl.uniprot.org/uniprot/A9CB60 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Citrullinated by PADI4.|||Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S) (By similarity).|||Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development.|||Cytoplasm|||Ufmylated by UFL1. http://togogenome.org/gene/9555:NANOS2 ^@ http://purl.uniprot.org/uniprot/A0A0A0MVX1 ^@ Similarity ^@ Belongs to the nanos family. http://togogenome.org/gene/9555:IL26 ^@ http://purl.uniprot.org/uniprot/A0A2I3LV89 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/9555:TMTC2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LS68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/9555:LOC100997415 ^@ http://purl.uniprot.org/uniprot/A0A096P0Z4 ^@ Similarity ^@ Belongs to the NipSnap family. http://togogenome.org/gene/9555:SLC16A7 ^@ http://purl.uniprot.org/uniprot/A0A096MKY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/9555:PMEPA1 ^@ http://purl.uniprot.org/uniprot/A0A8I5QZC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMEPA1 family.|||Early endosome membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/9555:ARAP1 ^@ http://purl.uniprot.org/uniprot/A0A096N7G3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:CLDND2 ^@ http://purl.uniprot.org/uniprot/A0A0A0MVL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/9555:LOC101015409 ^@ http://purl.uniprot.org/uniprot/A0A096NQN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9555:IGF1 ^@ http://purl.uniprot.org/uniprot/A0A096NGA2|||http://purl.uniprot.org/uniprot/A0A2I3MJX9|||http://purl.uniprot.org/uniprot/A0A2I3N9D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/9555:LOC101002868 ^@ http://purl.uniprot.org/uniprot/A0A096NZ91 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel (TC 1.A.1.10) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.|||Membrane http://togogenome.org/gene/9555:CNN2 ^@ http://purl.uniprot.org/uniprot/A0A096MNP3 ^@ Function|||Similarity ^@ Belongs to the calponin family.|||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. http://togogenome.org/gene/9555:IRF1 ^@ http://purl.uniprot.org/uniprot/A9CB09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Nucleus http://togogenome.org/gene/9555:MMP25 ^@ http://purl.uniprot.org/uniprot/A0A096NLA4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9555:WNT3 ^@ http://purl.uniprot.org/uniprot/A0A2I3MQZ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9555:FAM162A ^@ http://purl.uniprot.org/uniprot/A0A096N0Q1|||http://purl.uniprot.org/uniprot/A0A8I5MVE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0389 family.|||Membrane http://togogenome.org/gene/9555:LOC100998964 ^@ http://purl.uniprot.org/uniprot/A0A096N0E8|||http://purl.uniprot.org/uniprot/A0A2I3NIP0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.|||Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. http://togogenome.org/gene/9555:NTMT1 ^@ http://purl.uniprot.org/uniprot/A0A096P0H4 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. NTM1 family. http://togogenome.org/gene/9555:CCT3 ^@ http://purl.uniprot.org/uniprot/A0A096MLA9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.|||Cytoplasm http://togogenome.org/gene/9555:ADGRB2 ^@ http://purl.uniprot.org/uniprot/A0A2I3M7N7|||http://purl.uniprot.org/uniprot/A0A2I3NH10 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:B4GALT4 ^@ http://purl.uniprot.org/uniprot/A0A096N3C0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9555:DPYSL3 ^@ http://purl.uniprot.org/uniprot/A0A2I3LF07 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/9555:AQP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LZP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9555:VWC2 ^@ http://purl.uniprot.org/uniprot/A0A096NDN1 ^@ Subcellular Location Annotation ^@ Synapse http://togogenome.org/gene/9555:YIPF2 ^@ http://purl.uniprot.org/uniprot/A0A0A0MXJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Endosome membrane|||Golgi apparatus membrane|||Late endosome membrane|||Membrane|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/9555:PELO ^@ http://purl.uniprot.org/uniprot/A0A8I5N845 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, pelo recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel.|||Cytoplasm http://togogenome.org/gene/9555:ETF1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LZP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic release factor 1 family.|||Cytoplasm http://togogenome.org/gene/9555:DCLRE1C ^@ http://purl.uniprot.org/uniprot/E5FGI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/9555:LOC101020272 ^@ http://purl.uniprot.org/uniprot/A0A096NB70 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:PSMA1 ^@ http://purl.uniprot.org/uniprot/A0A096N1M9|||http://purl.uniprot.org/uniprot/A0A2I3LG13 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9555:APEH ^@ http://purl.uniprot.org/uniprot/A0A2I3MB32 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S9C family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/9555:SLC25A37 ^@ http://purl.uniprot.org/uniprot/A0A096MT96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9555:MLST8 ^@ http://purl.uniprot.org/uniprot/A0A096NL19 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat LST8 family.|||Cytoplasm|||Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB. Interacts with MEAK7. Interacts with SIK3.|||Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1. mTORC2 also modulates the phosphorylation of PRKCA. http://togogenome.org/gene/9555:ZKSCAN1 ^@ http://purl.uniprot.org/uniprot/A0A096MV28 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:IL2RG ^@ http://purl.uniprot.org/uniprot/A0A096MLC8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:DGKB ^@ http://purl.uniprot.org/uniprot/A0A096N1I6 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/9555:MDFI ^@ http://purl.uniprot.org/uniprot/A8MN24 ^@ Similarity ^@ Belongs to the MDFI family. http://togogenome.org/gene/9555:ZNF165 ^@ http://purl.uniprot.org/uniprot/A0A096NLJ3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:STK11IP ^@ http://purl.uniprot.org/uniprot/B0CM58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STK11IP family.|||Cytoplasm http://togogenome.org/gene/9555:MRPL13 ^@ http://purl.uniprot.org/uniprot/A0A8I5QZS2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/9555:CSTA ^@ http://purl.uniprot.org/uniprot/A0A8I5MY80 ^@ Similarity ^@ Belongs to the cystatin family. http://togogenome.org/gene/9555:SNU13 ^@ http://purl.uniprot.org/uniprot/A0A8I5R811 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/9555:IL33 ^@ http://purl.uniprot.org/uniprot/A0A096P1K1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family. Highly divergent.|||Chromosome|||Nucleus|||Secreted|||Vesicle|||secretory vesicle http://togogenome.org/gene/9555:KDM4A ^@ http://purl.uniprot.org/uniprot/A0A096ML87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JHDM3 histone demethylase family.|||Nucleus http://togogenome.org/gene/9555:HOXB6 ^@ http://purl.uniprot.org/uniprot/A0A096P427 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9555:LIPG ^@ http://purl.uniprot.org/uniprot/A0A096MXT1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9555:GGNBP2 ^@ http://purl.uniprot.org/uniprot/A0A096P510 ^@ Function ^@ May be involved in spermatogenesis. http://togogenome.org/gene/9555:BTG2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NCG3 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9555:MYMK ^@ http://purl.uniprot.org/uniprot/A0A096MSW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:NXPH2 ^@ http://purl.uniprot.org/uniprot/A0A096NSL2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/9555:NEMP2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NFW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NEMP family.|||Nucleus inner membrane http://togogenome.org/gene/9555:SYNJ1 ^@ http://purl.uniprot.org/uniprot/A0A096NBU6|||http://purl.uniprot.org/uniprot/A9CAZ0 ^@ Similarity ^@ Belongs to the synaptojanin family.|||In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family. http://togogenome.org/gene/9555:TAGLN ^@ http://purl.uniprot.org/uniprot/A0A096MZD7 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/9555:DPPA5 ^@ http://purl.uniprot.org/uniprot/A0A2I3LV22 ^@ Similarity ^@ Belongs to the KHDC1 family. http://togogenome.org/gene/9555:AQP2 ^@ http://purl.uniprot.org/uniprot/A0A096MRJ3|||http://purl.uniprot.org/uniprot/A0A2I3MR46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9555:DGAT1 ^@ http://purl.uniprot.org/uniprot/A0A096MYX7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Homodimer or homotetramer; both forms have similar enzymatic activities.|||Membrane http://togogenome.org/gene/9555:FAM13C ^@ http://purl.uniprot.org/uniprot/A0A8I5N5K7 ^@ Similarity ^@ Belongs to the FAM13 family. http://togogenome.org/gene/9555:PRND ^@ http://purl.uniprot.org/uniprot/A0A8I5NPX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prion family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:LIMS2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LRQ6|||http://purl.uniprot.org/uniprot/A0A2I3M329 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.|||Cell membrane|||Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.|||focal adhesion http://togogenome.org/gene/9555:CHD3 ^@ http://purl.uniprot.org/uniprot/A0A2I3LYT0|||http://purl.uniprot.org/uniprot/A0A2I3M2M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/9555:VPS37D ^@ http://purl.uniprot.org/uniprot/A0A096N4K3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/9555:DPH5 ^@ http://purl.uniprot.org/uniprot/A0A096MX22 ^@ Function|||Similarity ^@ Belongs to the diphthine synthase family.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/9555:SZRD1 ^@ http://purl.uniprot.org/uniprot/A0A096MQS9|||http://purl.uniprot.org/uniprot/A0A2I3LP04 ^@ Similarity ^@ Belongs to the SZRD1 family. http://togogenome.org/gene/9555:EDC3 ^@ http://purl.uniprot.org/uniprot/A0A096NMR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EDC3 family.|||P-body http://togogenome.org/gene/9555:TYW3 ^@ http://purl.uniprot.org/uniprot/A0A096N0K6 ^@ Function|||Similarity ^@ Belongs to the TYW3 family.|||Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. http://togogenome.org/gene/9555:CCNJ ^@ http://purl.uniprot.org/uniprot/A0A096P5T2 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9555:TRAPPC4 ^@ http://purl.uniprot.org/uniprot/A0A096ML79 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/9555:ACYP1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NVL0 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/9555:CCL17 ^@ http://purl.uniprot.org/uniprot/A0A096NIR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9555:GK2 ^@ http://purl.uniprot.org/uniprot/A0A096N0U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FGGY kinase family.|||Cytoplasm http://togogenome.org/gene/9555:MLLT1 ^@ http://purl.uniprot.org/uniprot/A0A0A0MX97 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:SCPEP1 ^@ http://purl.uniprot.org/uniprot/A0A096P4R6 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/9555:OGFRL1 ^@ http://purl.uniprot.org/uniprot/A0A096NQE5 ^@ Similarity ^@ Belongs to the opioid growth factor receptor family. http://togogenome.org/gene/9555:GNAL ^@ http://purl.uniprot.org/uniprot/A0A8I5R0H1 ^@ Similarity ^@ Belongs to the G-alpha family. G(s) subfamily. http://togogenome.org/gene/9555:P2RY2 ^@ http://purl.uniprot.org/uniprot/A0A096N579 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:LOC103882072 ^@ http://purl.uniprot.org/uniprot/A0A8I5QZI4 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9555:TMEM65 ^@ http://purl.uniprot.org/uniprot/A0A096N0D0|||http://purl.uniprot.org/uniprot/A0A8I5N2N3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:GHITM ^@ http://purl.uniprot.org/uniprot/A0A096NW88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9555:DKC1 ^@ http://purl.uniprot.org/uniprot/A9CB73 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/9555:PSMD12 ^@ http://purl.uniprot.org/uniprot/A0A2I3MHT1 ^@ Similarity ^@ Belongs to the proteasome subunit p55 family. http://togogenome.org/gene/9555:ARAF ^@ http://purl.uniprot.org/uniprot/A0A096MVH2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. http://togogenome.org/gene/9555:TNFSF11 ^@ http://purl.uniprot.org/uniprot/A0A2I3LEX1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Homotrimer.|||Membrane|||Secreted http://togogenome.org/gene/9555:RBM17 ^@ http://purl.uniprot.org/uniprot/A0A2I3MCZ3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with the spliceosome.|||Nucleus|||Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. http://togogenome.org/gene/9555:UGGT2 ^@ http://purl.uniprot.org/uniprot/A0A096NGL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 8 family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9555:CDK19 ^@ http://purl.uniprot.org/uniprot/A0A096N1F0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:ATP2B2 ^@ http://purl.uniprot.org/uniprot/A0A096MPW1|||http://purl.uniprot.org/uniprot/A0A2I3LLL0|||http://purl.uniprot.org/uniprot/A0A2I3MV53|||http://purl.uniprot.org/uniprot/A0A2I3MZ32|||http://purl.uniprot.org/uniprot/A0A2I3NBE1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:LOC101021945 ^@ http://purl.uniprot.org/uniprot/A0A096N7J3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:ARSJ ^@ http://purl.uniprot.org/uniprot/A0A096MYQ7|||http://purl.uniprot.org/uniprot/A0A2I3LHU2 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9555:FFAR1 ^@ http://purl.uniprot.org/uniprot/A0A2I3N538 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9555:THEMIS ^@ http://purl.uniprot.org/uniprot/A0A2I3M1C6 ^@ Similarity ^@ Belongs to the themis family. http://togogenome.org/gene/9555:OGG1 ^@ http://purl.uniprot.org/uniprot/A0A096NQ19 ^@ Function|||Similarity ^@ Belongs to the type-1 OGG1 family.|||DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. http://togogenome.org/gene/9555:EIF4A2 ^@ http://purl.uniprot.org/uniprot/A0A096MMP1 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family. eIF4A subfamily.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9555:CCL20 ^@ http://purl.uniprot.org/uniprot/A0A096N8Z6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9555:TAF8 ^@ http://purl.uniprot.org/uniprot/A0A096NI46|||http://purl.uniprot.org/uniprot/A0A8I5MWR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF8 family.|||Nucleus http://togogenome.org/gene/9555:NRG1 ^@ http://purl.uniprot.org/uniprot/A0A096NYH2|||http://purl.uniprot.org/uniprot/A0A2I3MB55|||http://purl.uniprot.org/uniprot/A0A2I3MB56|||http://purl.uniprot.org/uniprot/A0A2I3ND73|||http://purl.uniprot.org/uniprot/A0A2I3NI55 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neuregulin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Secreted http://togogenome.org/gene/9555:RIN1 ^@ http://purl.uniprot.org/uniprot/A0A096N6Q2 ^@ Similarity ^@ Belongs to the RIN (Ras interaction/interference) family. http://togogenome.org/gene/9555:MAGOH ^@ http://purl.uniprot.org/uniprot/A0A2I3MAT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mago nashi family.|||Nucleus http://togogenome.org/gene/9555:EHD4 ^@ http://purl.uniprot.org/uniprot/A0A096NTQ8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/9555:TMEM178A ^@ http://purl.uniprot.org/uniprot/A0A8I5NB40|||http://purl.uniprot.org/uniprot/A0A8I5NLE0 ^@ Similarity ^@ Belongs to the TMEM178 family. http://togogenome.org/gene/9555:FBXO9 ^@ http://purl.uniprot.org/uniprot/A0A8I5NF07 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2.|||Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1. Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway. Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation. http://togogenome.org/gene/9555:HSD17B10 ^@ http://purl.uniprot.org/uniprot/A0A096NBK4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9555:KCNJ8 ^@ http://purl.uniprot.org/uniprot/A0A8I5NFH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9555:UBE2F ^@ http://purl.uniprot.org/uniprot/A0A096N971|||http://purl.uniprot.org/uniprot/A0A2I3MGC6 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9555:MS4A13 ^@ http://purl.uniprot.org/uniprot/A0A096MW79 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9555:KDM5C ^@ http://purl.uniprot.org/uniprot/A0A096N7F8|||http://purl.uniprot.org/uniprot/A0A2I3MI67 ^@ Similarity ^@ Belongs to the JARID1 histone demethylase family. http://togogenome.org/gene/9555:LOC101011060 ^@ http://purl.uniprot.org/uniprot/A0A096MZA0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:UBALD1 ^@ http://purl.uniprot.org/uniprot/A0A096NLF5 ^@ Similarity ^@ Belongs to the UBALD family. http://togogenome.org/gene/9555:CCM2L ^@ http://purl.uniprot.org/uniprot/A0A8I5N2R4 ^@ Similarity ^@ Belongs to the CCM2 family. http://togogenome.org/gene/9555:MARCHF9 ^@ http://purl.uniprot.org/uniprot/A0A096NH00 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:RPL8 ^@ http://purl.uniprot.org/uniprot/A0A2I3N473 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/9555:FGF1 ^@ http://purl.uniprot.org/uniprot/B0CM87 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heparin-binding growth factors family.|||Cytoplasm|||Nucleus|||Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.|||Secreted|||cell cortex|||cytosol http://togogenome.org/gene/9555:SEC22B ^@ http://purl.uniprot.org/uniprot/A0A8I5NMA2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Melanosome|||Membrane|||SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/9555:ERG28 ^@ http://purl.uniprot.org/uniprot/A0A096NS56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG28 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:CDC14A ^@ http://purl.uniprot.org/uniprot/A0A2I3MKZ0 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily. http://togogenome.org/gene/9555:RABGGTB ^@ http://purl.uniprot.org/uniprot/A0A096P020 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit beta family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX. http://togogenome.org/gene/9555:GPR37L1 ^@ http://purl.uniprot.org/uniprot/A0A096MSR1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9555:PLBD2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NRS6 ^@ Function|||Similarity ^@ Belongs to the phospholipase B-like family.|||Putative phospholipase. http://togogenome.org/gene/9555:GNAT3 ^@ http://purl.uniprot.org/uniprot/A0A096NRM0 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9555:PPP1R14A ^@ http://purl.uniprot.org/uniprot/A0A2I3M7M7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PP1 inhibitor family.|||Cytoplasm|||Inhibitor of PPP1CA. http://togogenome.org/gene/9555:ERO1B ^@ http://purl.uniprot.org/uniprot/A0A2I3M8I9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EROs family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9555:FAM126B ^@ http://purl.uniprot.org/uniprot/A0A096NBZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Hyccin family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/9555:GDI2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MLM6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP. http://togogenome.org/gene/9555:ITGB3 ^@ http://purl.uniprot.org/uniprot/A0A2I3MIT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:FAM149B1 ^@ http://purl.uniprot.org/uniprot/A0A096P4P3 ^@ Similarity ^@ Belongs to the FAM149 family. http://togogenome.org/gene/9555:LDHB ^@ http://purl.uniprot.org/uniprot/J9QRH6 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/9555:ICAM3 ^@ http://purl.uniprot.org/uniprot/A0A0A0MV25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. ICAM family.|||Membrane http://togogenome.org/gene/9555:TMEM8B ^@ http://purl.uniprot.org/uniprot/A0A096P165 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:CDKN3 ^@ http://purl.uniprot.org/uniprot/A0A096NV50 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family.|||May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues.|||perinuclear region http://togogenome.org/gene/9555:TLX1 ^@ http://purl.uniprot.org/uniprot/A0A096P6B4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:NUDT7 ^@ http://purl.uniprot.org/uniprot/A0A2I3LHE7 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. PCD1 subfamily. http://togogenome.org/gene/9555:FEV ^@ http://purl.uniprot.org/uniprot/A0A096N222 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9555:RPS23 ^@ http://purl.uniprot.org/uniprot/A0A096NP85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS12 family.|||Rough endoplasmic reticulum http://togogenome.org/gene/9555:LHFPL2 ^@ http://purl.uniprot.org/uniprot/A0A096NCI1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:GABRA2 ^@ http://purl.uniprot.org/uniprot/A0A096NAY9|||http://purl.uniprot.org/uniprot/A0A2I3LYD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||dendrite http://togogenome.org/gene/9555:PUF60 ^@ http://purl.uniprot.org/uniprot/A0A2I3M7U8|||http://purl.uniprot.org/uniprot/A0A2I3MX19|||http://purl.uniprot.org/uniprot/A0A2I3MY22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM half pint family.|||Nucleus http://togogenome.org/gene/9555:PABPC1 ^@ http://purl.uniprot.org/uniprot/A0A096N729 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyadenylate-binding protein type-1 family.|||Binds the poly(A) tail of mRNA.|||Cytoplasm http://togogenome.org/gene/9555:ANAPC13 ^@ http://purl.uniprot.org/uniprot/A0A8I5NBJ0 ^@ Function|||Similarity ^@ Belongs to the APC13 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. http://togogenome.org/gene/9555:MPP1 ^@ http://purl.uniprot.org/uniprot/A9CB74 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MAGUK family.|||Cell membrane|||Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity).|||Heterodimer with PALS1. Interacts with DLG5 and NF2. Interacts (via guanylate kinase-like domain) with WHRN (via third PDZ domain) (By similarity).|||Palmitoylated.|||stereocilium http://togogenome.org/gene/9555:ASZ1 ^@ http://purl.uniprot.org/uniprot/Q8WMX7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.|||Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity). http://togogenome.org/gene/9555:SPIN1 ^@ http://purl.uniprot.org/uniprot/A0A096P1X6 ^@ Similarity ^@ Belongs to the SPIN/STSY family. http://togogenome.org/gene/9555:TTC27 ^@ http://purl.uniprot.org/uniprot/A0A096MNE2 ^@ Similarity ^@ Belongs to the TTC27 family. http://togogenome.org/gene/9555:B3GALNT2 ^@ http://purl.uniprot.org/uniprot/A0A096MSY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9555:STS ^@ http://purl.uniprot.org/uniprot/A0A096NP88|||http://purl.uniprot.org/uniprot/A0A2I3LME9 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9555:YME1L1 ^@ http://purl.uniprot.org/uniprot/A0A096P3U9 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/9555:LRRFIP1 ^@ http://purl.uniprot.org/uniprot/A0A096MUM7|||http://purl.uniprot.org/uniprot/A0A2I3NI33 ^@ Similarity ^@ Belongs to the LRRFIP family. http://togogenome.org/gene/9555:DNASE1L1 ^@ http://purl.uniprot.org/uniprot/A9CB61 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/9555:ZNF496 ^@ http://purl.uniprot.org/uniprot/A0A096MNV5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:EDN3 ^@ http://purl.uniprot.org/uniprot/A0A2I3NH98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Secreted http://togogenome.org/gene/9555:LOC101003204 ^@ http://purl.uniprot.org/uniprot/A0A096MPY9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:ITM2A ^@ http://purl.uniprot.org/uniprot/A0A8I5N930 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITM2 family.|||Membrane http://togogenome.org/gene/9555:MPV17 ^@ http://purl.uniprot.org/uniprot/A0A096NH61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/9555:SRC ^@ http://purl.uniprot.org/uniprot/A0A2I3M0W2|||http://purl.uniprot.org/uniprot/A0A2I3MCC2|||http://purl.uniprot.org/uniprot/A0A2I3N2L0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9555:TP53BP1 ^@ http://purl.uniprot.org/uniprot/A9X1B3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:NOS1 ^@ http://purl.uniprot.org/uniprot/A0A096N287 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOS family.|||dendritic spine|||sarcolemma http://togogenome.org/gene/9555:ATP6V0A1 ^@ http://purl.uniprot.org/uniprot/A0A096P5T1|||http://purl.uniprot.org/uniprot/A0A2I3LMH7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/9555:LOC101013367 ^@ http://purl.uniprot.org/uniprot/A0A096NW98 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:CXHXorf56 ^@ http://purl.uniprot.org/uniprot/A0A096MNT2 ^@ Similarity ^@ Belongs to the STEEP1 family. http://togogenome.org/gene/9555:STN1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NKM5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the STN1 family.|||Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.|||Component of the CST complex.|||Nucleus|||telomere http://togogenome.org/gene/9555:IFT43 ^@ http://purl.uniprot.org/uniprot/A0A096NS62 ^@ Similarity ^@ Belongs to the IFT43 family. http://togogenome.org/gene/9555:LOC101008229 ^@ http://purl.uniprot.org/uniprot/A0A096NZ12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:STXBP5L ^@ http://purl.uniprot.org/uniprot/A0A096MLF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat L(2)GL family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9555:LOC101003762 ^@ http://purl.uniprot.org/uniprot/A0A096NE00 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:LOC101019806 ^@ http://purl.uniprot.org/uniprot/A0A2I3N7F2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family.|||Binds 2 Zn(2+) ions per subunit.|||Cytoplasm http://togogenome.org/gene/9555:MARCKSL1 ^@ http://purl.uniprot.org/uniprot/A0A096NFT8 ^@ Similarity ^@ Belongs to the MARCKS family. http://togogenome.org/gene/9555:SGTB ^@ http://purl.uniprot.org/uniprot/A0A096MW67 ^@ Similarity ^@ Belongs to the SGT family. http://togogenome.org/gene/9555:GJB3 ^@ http://purl.uniprot.org/uniprot/A0A8I5R004 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9555:ACO1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NLS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Cytoplasm http://togogenome.org/gene/9555:SPEM1 ^@ http://purl.uniprot.org/uniprot/A0A096P2P9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:SLC29A2 ^@ http://purl.uniprot.org/uniprot/A0A096NC17 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Basolateral cell membrane|||Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9555:ACTG2 ^@ http://purl.uniprot.org/uniprot/A0A096NZ53 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9555:SPI1 ^@ http://purl.uniprot.org/uniprot/A0A096N548 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9555:PSMA4 ^@ http://purl.uniprot.org/uniprot/A0A096NMW0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9555:PPP3CB ^@ http://purl.uniprot.org/uniprot/A0A2I3LGU2 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-2B subfamily. http://togogenome.org/gene/9555:SCAP ^@ http://purl.uniprot.org/uniprot/A0A2I3LM27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SCAP family.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane http://togogenome.org/gene/9555:UBE2E2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LWV8 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9555:HTRA1 ^@ http://purl.uniprot.org/uniprot/A0A096NU19 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/9555:HOMEZ ^@ http://purl.uniprot.org/uniprot/A0A096MSW0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:TK1 ^@ http://purl.uniprot.org/uniprot/A0A096NT67 ^@ Similarity ^@ Belongs to the thymidine kinase family. http://togogenome.org/gene/9555:MALL ^@ http://purl.uniprot.org/uniprot/A0A8I5MXR2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:MED8 ^@ http://purl.uniprot.org/uniprot/A0A2I3LC98|||http://purl.uniprot.org/uniprot/A0A2I3M366 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 8 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9555:YPEL5 ^@ http://purl.uniprot.org/uniprot/A0A8I5NVL8 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9555:RUNX1T1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LCQ1|||http://purl.uniprot.org/uniprot/A0A2I3LPI1 ^@ Similarity ^@ Belongs to the CBFA2T family. http://togogenome.org/gene/9555:PRM1 ^@ http://purl.uniprot.org/uniprot/A0A096MLL5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protamine P1 family.|||Chromosome|||Nucleus|||Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. http://togogenome.org/gene/9555:LOC100998121 ^@ http://purl.uniprot.org/uniprot/A0A096NCU8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||gap junction http://togogenome.org/gene/9555:NDUFAF2 ^@ http://purl.uniprot.org/uniprot/A0A096MVZ2 ^@ Similarity ^@ Belongs to the complex I NDUFA12 subunit family. http://togogenome.org/gene/9555:CD55 ^@ http://purl.uniprot.org/uniprot/A0A096NAP3|||http://purl.uniprot.org/uniprot/A0A2I3LDB2|||http://purl.uniprot.org/uniprot/A0A2I3MCJ7|||http://purl.uniprot.org/uniprot/A0A2I3MM21 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:ATG3 ^@ http://purl.uniprot.org/uniprot/A0A096NWY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG3 family.|||Cytoplasm http://togogenome.org/gene/9555:DOLK ^@ http://purl.uniprot.org/uniprot/B0CM92 ^@ Similarity ^@ Belongs to the polyprenol kinase family. http://togogenome.org/gene/9555:BRD1 ^@ http://purl.uniprot.org/uniprot/A0A2I3N4K1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:LDB1 ^@ http://purl.uniprot.org/uniprot/A0A096P6D1 ^@ Similarity ^@ Belongs to the LDB family. http://togogenome.org/gene/9555:ADRA1A ^@ http://purl.uniprot.org/uniprot/A0A2I3M6I3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Membrane|||Nucleus membrane|||caveola http://togogenome.org/gene/9555:NECAP1 ^@ http://purl.uniprot.org/uniprot/A0A096N505 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NECAP family.|||Involved in endocytosis.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9555:CPLX2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LG01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9555:ATG4B ^@ http://purl.uniprot.org/uniprot/A0A8I5NRJ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/9555:SAP130 ^@ http://purl.uniprot.org/uniprot/A0A096MY85|||http://purl.uniprot.org/uniprot/A0A8I5N2G0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAP130 family.|||Nucleus http://togogenome.org/gene/9555:PDE9A ^@ http://purl.uniprot.org/uniprot/A0A096NIS9|||http://purl.uniprot.org/uniprot/A0A2I3M0X7 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9555:SLC7A6OS ^@ http://purl.uniprot.org/uniprot/A0A096P003 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IWR1/SLC7A6OS family.|||Cytoplasm|||Directs RNA polymerase II nuclear import.|||Nucleus http://togogenome.org/gene/9555:MOB3B ^@ http://purl.uniprot.org/uniprot/A0A096P1E3 ^@ Similarity ^@ Belongs to the MOB1/phocein family. http://togogenome.org/gene/9555:MCOLN1 ^@ http://purl.uniprot.org/uniprot/A0A0A0MWC3 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9555:LOC101010987 ^@ http://purl.uniprot.org/uniprot/A0A8I5N1W0 ^@ Similarity ^@ Belongs to the histone H2B family. http://togogenome.org/gene/9555:TOMM20 ^@ http://purl.uniprot.org/uniprot/A0A096MUL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom20 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9555:LOC103875518 ^@ http://purl.uniprot.org/uniprot/A0A2I3LGJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX16 family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:HYAL3 ^@ http://purl.uniprot.org/uniprot/A0A096MWQ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 56 family.|||Cell membrane|||Early endosome|||Endoplasmic reticulum|||Endosome|||Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage.|||Membrane|||acrosome http://togogenome.org/gene/9555:PNRC1 ^@ http://purl.uniprot.org/uniprot/A0A096P094 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:LBR ^@ http://purl.uniprot.org/uniprot/A0A096MUV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/9555:LOC103883790 ^@ http://purl.uniprot.org/uniprot/A0A096NSH2 ^@ Similarity ^@ Belongs to the KHDC1 family. http://togogenome.org/gene/9555:UBA1 ^@ http://purl.uniprot.org/uniprot/A0A096N6N8 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/9555:TCEANC ^@ http://purl.uniprot.org/uniprot/A0A096NCP9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:LCLAT1 ^@ http://purl.uniprot.org/uniprot/A0A096N154 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9555:UXS1 ^@ http://purl.uniprot.org/uniprot/A0A8I5N4X7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9555:UBALD2 ^@ http://purl.uniprot.org/uniprot/A0A096NT32 ^@ Similarity ^@ Belongs to the UBALD family. http://togogenome.org/gene/9555:CA10 ^@ http://purl.uniprot.org/uniprot/A0A2I3MEL8 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Does not have a catalytic activity. http://togogenome.org/gene/9555:RDH5 ^@ http://purl.uniprot.org/uniprot/A0A096NGJ2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9555:ND6 ^@ http://purl.uniprot.org/uniprot/K9MUH0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 6 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion inner membrane|||Mitochondrion membrane http://togogenome.org/gene/9555:LGI1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MFS5|||http://purl.uniprot.org/uniprot/A0A2I3MHY1 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9555:ILDR1 ^@ http://purl.uniprot.org/uniprot/A0A096N9E2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. LISCH7 family.|||Membrane|||tight junction http://togogenome.org/gene/9555:DPH3 ^@ http://purl.uniprot.org/uniprot/A0A096N1S9|||http://purl.uniprot.org/uniprot/A0A8I5MYZ2 ^@ Similarity ^@ Belongs to the DPH3 family. http://togogenome.org/gene/9555:ILDR2 ^@ http://purl.uniprot.org/uniprot/A0A8I5P391 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. LISCH7 family.|||Membrane|||tight junction http://togogenome.org/gene/9555:ZPBP ^@ http://purl.uniprot.org/uniprot/A0A8I5MVV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the zona pellucida-binding protein Sp38 family.|||Secreted|||acrosome http://togogenome.org/gene/9555:DUSP4 ^@ http://purl.uniprot.org/uniprot/A0A8I5ND71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/9555:LOC101005212 ^@ http://purl.uniprot.org/uniprot/A0A096MUI3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9555:S100A5 ^@ http://purl.uniprot.org/uniprot/A0A096MUG5 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9555:BTDC ^@ http://purl.uniprot.org/uniprot/B6ULW6 ^@ Function|||PTM|||Similarity|||Subunit ^@ BTD-4 has antimicrobial activity against the Gram-negative bacterium E.coli ML35, the Gram-positive bacterium S.aureus 502a, and the fungus C.albicans 16820.|||BTD-4 is a cyclic heterodimer composed of subunits A and C; disulfide-linked.|||Belongs to the alpha-defensin family. Theta subfamily.|||Forms a cyclic peptide with subunit A (BTD-4). An additional intersubunit disulfide bond is formed. http://togogenome.org/gene/9555:SOD2 ^@ http://purl.uniprot.org/uniprot/A0A8I5MUU4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems.|||Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.|||Homotetramer.|||Mitochondrion matrix http://togogenome.org/gene/9555:BCOR ^@ http://purl.uniprot.org/uniprot/A0A096N4A9|||http://purl.uniprot.org/uniprot/A0A2I3M3P3|||http://purl.uniprot.org/uniprot/A0A2I3M9S8 ^@ Similarity ^@ Belongs to the BCOR family. http://togogenome.org/gene/9555:EPHA5 ^@ http://purl.uniprot.org/uniprot/A0A096N147|||http://purl.uniprot.org/uniprot/A0A2I3MPF6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:C1H1orf74 ^@ http://purl.uniprot.org/uniprot/A0A096NFJ6 ^@ Similarity ^@ Belongs to the UPF0739 family. http://togogenome.org/gene/9555:KDM1A ^@ http://purl.uniprot.org/uniprot/A0A2I3M6T6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the flavin monoamine oxidase family.|||Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity.|||Nucleus|||The SWIRM domain may act as an anchor site for a histone tail. http://togogenome.org/gene/9555:ANP32E ^@ http://purl.uniprot.org/uniprot/A0A096N087|||http://purl.uniprot.org/uniprot/A0A2I3MVQ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANP32 family.|||Multifunctional protein that is involved in the regulation of many processes.|||Nucleus http://togogenome.org/gene/9555:RAD54L2 ^@ http://purl.uniprot.org/uniprot/A0A096NYI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/9555:HMGCL ^@ http://purl.uniprot.org/uniprot/A0A2I3MZE1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HMG-CoA lyase family.|||Homodimer; disulfide-linked. Can also form homotetramers.|||Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. http://togogenome.org/gene/9555:CADM3 ^@ http://purl.uniprot.org/uniprot/A0A096NQF2|||http://purl.uniprot.org/uniprot/A0A2I3MK19 ^@ Similarity ^@ Belongs to the nectin family. http://togogenome.org/gene/9555:PFN3 ^@ http://purl.uniprot.org/uniprot/A0A8I5NC12 ^@ Similarity ^@ Belongs to the profilin family. http://togogenome.org/gene/9555:CDK4 ^@ http://purl.uniprot.org/uniprot/A0A096N5E4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:DDX21 ^@ http://purl.uniprot.org/uniprot/A0A8I5P1Q9 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily. http://togogenome.org/gene/9555:CALY ^@ http://purl.uniprot.org/uniprot/A0A8I5N1Z3 ^@ Similarity ^@ Belongs to the NSG family. http://togogenome.org/gene/9555:GSTK1 ^@ http://purl.uniprot.org/uniprot/A0A2I3N8T9 ^@ Similarity ^@ Belongs to the GST superfamily. Kappa family. http://togogenome.org/gene/9555:SELENOT ^@ http://purl.uniprot.org/uniprot/A0A8I5N335 ^@ Similarity ^@ Belongs to the SelWTH family. Selenoprotein T subfamily. http://togogenome.org/gene/9555:RPIA ^@ http://purl.uniprot.org/uniprot/A0A2I3LEH6 ^@ Similarity ^@ Belongs to the ribose 5-phosphate isomerase family. http://togogenome.org/gene/9555:CCNI ^@ http://purl.uniprot.org/uniprot/A0A096MVW4 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9555:ABCC9 ^@ http://purl.uniprot.org/uniprot/A0A2I3LNL6|||http://purl.uniprot.org/uniprot/A0A2I3N477 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with KCNJ11.|||Membrane http://togogenome.org/gene/9555:RPS11 ^@ http://purl.uniprot.org/uniprot/A0A096MQQ2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/9555:PHC2 ^@ http://purl.uniprot.org/uniprot/A0A8I5R8L6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:SIAH2 ^@ http://purl.uniprot.org/uniprot/A0A096MUM5 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/9555:GRHL2 ^@ http://purl.uniprot.org/uniprot/A0A096MXW7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:FADS3 ^@ http://purl.uniprot.org/uniprot/B8R1J9 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:HIKESHI ^@ http://purl.uniprot.org/uniprot/A0A8I5N2W1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.|||Belongs to the OPI10 family.|||Cytoplasm|||Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.|||Nucleus|||cytosol http://togogenome.org/gene/9555:LOC101004221 ^@ http://purl.uniprot.org/uniprot/A0A096MUU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9555:MITF ^@ http://purl.uniprot.org/uniprot/A0A096N6Y8|||http://purl.uniprot.org/uniprot/A0A2I3M2E5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/9555:FAM13B ^@ http://purl.uniprot.org/uniprot/A0A096NB74|||http://purl.uniprot.org/uniprot/A0A2I3M1R0|||http://purl.uniprot.org/uniprot/A0A2I3N0R8|||http://purl.uniprot.org/uniprot/A0A8I5NVH1 ^@ Similarity ^@ Belongs to the FAM13 family. http://togogenome.org/gene/9555:ISOC1 ^@ http://purl.uniprot.org/uniprot/A0A096MMR9 ^@ Similarity ^@ Belongs to the isochorismatase family. http://togogenome.org/gene/9555:RDH10 ^@ http://purl.uniprot.org/uniprot/A0A096NEU8 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9555:FAM166B ^@ http://purl.uniprot.org/uniprot/A0A8I5NUT0 ^@ Similarity ^@ Belongs to the CIMIP2 family. http://togogenome.org/gene/9555:TXNRD1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LX18 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/9555:GPD1L ^@ http://purl.uniprot.org/uniprot/A0A096P025 ^@ Similarity ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/9555:TELO2 ^@ http://purl.uniprot.org/uniprot/A0A096NKS4 ^@ Similarity ^@ Belongs to the TEL2 family. http://togogenome.org/gene/9555:TSPAN3 ^@ http://purl.uniprot.org/uniprot/A0A096NMU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9555:AKT3 ^@ http://purl.uniprot.org/uniprot/A0A096MRG7|||http://purl.uniprot.org/uniprot/A0A8I5NSS2|||http://purl.uniprot.org/uniprot/A0A8I5R117 ^@ Similarity ^@ Belongs to the protein kinase superfamily.|||Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. http://togogenome.org/gene/9555:THOP1 ^@ http://purl.uniprot.org/uniprot/A0A0A0MXC1 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/9555:ERP29 ^@ http://purl.uniprot.org/uniprot/A0A096NE61 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Does not seem to be a disulfide isomerase.|||Endoplasmic reticulum lumen|||Homodimer.|||Melanosome http://togogenome.org/gene/9555:CDC42SE2 ^@ http://purl.uniprot.org/uniprot/A0A096MTW6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CDC42SE/SPEC family.|||Cell membrane|||Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.|||Membrane|||Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.|||cytoskeleton http://togogenome.org/gene/9555:PABPC1L ^@ http://purl.uniprot.org/uniprot/A0A096NX83 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyadenylate-binding protein type-1 family.|||Binds the poly(A) tail of mRNA.|||Cytoplasm http://togogenome.org/gene/9555:SGCZ ^@ http://purl.uniprot.org/uniprot/A0A096NZ75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/9555:NRXN2 ^@ http://purl.uniprot.org/uniprot/B0CM62 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:DDX53 ^@ http://purl.uniprot.org/uniprot/A0A8I5NYB6 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9555:DHRS7B ^@ http://purl.uniprot.org/uniprot/A0A096P358|||http://purl.uniprot.org/uniprot/A0A2I3LW45 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9555:KCTD3 ^@ http://purl.uniprot.org/uniprot/A0A096MRS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KCTD3 family.|||Cell membrane http://togogenome.org/gene/9555:FAM98A ^@ http://purl.uniprot.org/uniprot/A0A096NY88 ^@ Similarity ^@ Belongs to the FAM98 family. http://togogenome.org/gene/9555:ND4L ^@ http://purl.uniprot.org/uniprot/K9MTI3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 4L family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:SGSM3 ^@ http://purl.uniprot.org/uniprot/A0A2I3NHU9 ^@ Similarity ^@ Belongs to the small G protein signaling modulator family. http://togogenome.org/gene/9555:ABCG4 ^@ http://purl.uniprot.org/uniprot/A0A2I3M380 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/9555:SLC10A5 ^@ http://purl.uniprot.org/uniprot/A0A096NCL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/9555:BARX1 ^@ http://purl.uniprot.org/uniprot/A0A096P252 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:LOC100999326 ^@ http://purl.uniprot.org/uniprot/A0A8I5R2B7 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/9555:LOC101016759 ^@ http://purl.uniprot.org/uniprot/A0A096P4M5|||http://purl.uniprot.org/uniprot/A0A8I5QZP3 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9555:ILF3 ^@ http://purl.uniprot.org/uniprot/A0A0A0MX95|||http://purl.uniprot.org/uniprot/A0A2I3MBY8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9555:EXOSC7 ^@ http://purl.uniprot.org/uniprot/A0A096NDA1|||http://purl.uniprot.org/uniprot/A0A2I3LP41 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:PHF5A ^@ http://purl.uniprot.org/uniprot/A0A096NKA7 ^@ Similarity ^@ Belongs to the PHF5 family. http://togogenome.org/gene/9555:TUB ^@ http://purl.uniprot.org/uniprot/A0A8I5MZD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TUB family.|||Secreted http://togogenome.org/gene/9555:LOC101010649 ^@ http://purl.uniprot.org/uniprot/A9RA98 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:UBE2D3 ^@ http://purl.uniprot.org/uniprot/A0A2I3M270|||http://purl.uniprot.org/uniprot/A0A2I3NG84 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9555:ALDOC ^@ http://purl.uniprot.org/uniprot/A0A096P398 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/9555:LOC103876796 ^@ http://purl.uniprot.org/uniprot/A0A096MNL1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS8 family. http://togogenome.org/gene/9555:ANXA1 ^@ http://purl.uniprot.org/uniprot/A0A8I5MZ82 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Basolateral cell membrane|||Belongs to the annexin family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Early endosome|||Endosome membrane|||Lateral cell membrane|||Membrane|||Nucleus|||The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.|||cilium|||extracellular exosome|||extracellular space|||phagocytic cup|||secretory vesicle lumen http://togogenome.org/gene/9555:IL5 ^@ http://purl.uniprot.org/uniprot/A9CB10 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-5 family.|||Homodimer; disulfide-linked.|||Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively.|||Secreted http://togogenome.org/gene/9555:SH3BP5L ^@ http://purl.uniprot.org/uniprot/A0A2I3N9T5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SH3BP5 family.|||Cytoplasm|||Functions as guanine nucleotide exchange factor (GEF) for RAB11A.|||Interacts with GDP-bound and nucleotide-free forms of RAB11A.|||The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape. http://togogenome.org/gene/9555:TXLNB ^@ http://purl.uniprot.org/uniprot/A0A8I5NJQ3 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/9555:OR51L1 ^@ http://purl.uniprot.org/uniprot/A9L8W5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:E2F4 ^@ http://purl.uniprot.org/uniprot/A0A096NJB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9555:HS3ST1 ^@ http://purl.uniprot.org/uniprot/A0A096MMR1 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9555:AMOTL2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NV60 ^@ Similarity ^@ Belongs to the angiomotin family. http://togogenome.org/gene/9555:TBX20 ^@ http://purl.uniprot.org/uniprot/A0A096N256 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9555:PYGB ^@ http://purl.uniprot.org/uniprot/A0A096NVV1 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/9555:TCF7L1 ^@ http://purl.uniprot.org/uniprot/A0A096MTR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCF/LEF family.|||Nucleus http://togogenome.org/gene/9555:NLRP14 ^@ http://purl.uniprot.org/uniprot/A0A096MSZ9 ^@ Similarity ^@ Belongs to the NLRP family. http://togogenome.org/gene/9555:OASL ^@ http://purl.uniprot.org/uniprot/A0A096NE60 ^@ Similarity ^@ Belongs to the 2-5A synthase family. http://togogenome.org/gene/9555:MYO1D ^@ http://purl.uniprot.org/uniprot/A0A2I3N540 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9555:IRF7 ^@ http://purl.uniprot.org/uniprot/A0A096MQH1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:ADCY3 ^@ http://purl.uniprot.org/uniprot/A0A096MP68 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/9555:PANX2 ^@ http://purl.uniprot.org/uniprot/A0A096NKW6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Membrane|||Structural component of the gap junctions and the hemichannels.|||gap junction http://togogenome.org/gene/9555:DRAM2 ^@ http://purl.uniprot.org/uniprot/A0A096NCJ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:AICDA ^@ http://purl.uniprot.org/uniprot/A0A2I3MXX2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:TRHR ^@ http://purl.uniprot.org/uniprot/A0A096NAR2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. http://togogenome.org/gene/9555:SNX10 ^@ http://purl.uniprot.org/uniprot/A0A096NGV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane http://togogenome.org/gene/9555:HOXA4 ^@ http://purl.uniprot.org/uniprot/A9L939 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9555:TMEM267 ^@ http://purl.uniprot.org/uniprot/A0A096N1M3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:BAAT ^@ http://purl.uniprot.org/uniprot/A0A2I3M7H0 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/9555:TMEM30A ^@ http://purl.uniprot.org/uniprot/A0A096NYP1 ^@ Similarity ^@ Belongs to the CDC50/LEM3 family. http://togogenome.org/gene/9555:ALDH8A1 ^@ http://purl.uniprot.org/uniprot/A0A096MXD8 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9555:LOC101005841 ^@ http://purl.uniprot.org/uniprot/A0A096MLZ6 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:SST ^@ http://purl.uniprot.org/uniprot/A0A096NC87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatostatin family.|||Secreted http://togogenome.org/gene/9555:BBS5 ^@ http://purl.uniprot.org/uniprot/A0A096NZB9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BBS5 family.|||Membrane|||Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10.|||The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.|||centriolar satellite|||cilium membrane http://togogenome.org/gene/9555:CXCR6 ^@ http://purl.uniprot.org/uniprot/A0A096MQA3 ^@ Function|||Similarity ^@ Belongs to the G-protein coupled receptor 1 family.|||Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1. http://togogenome.org/gene/9555:ATPAF2 ^@ http://purl.uniprot.org/uniprot/A0A096P326 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP12 family.|||Mitochondrion http://togogenome.org/gene/9555:STMN4 ^@ http://purl.uniprot.org/uniprot/A0A096N8M9|||http://purl.uniprot.org/uniprot/A0A2I3NGF5 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/9555:SERPINA4 ^@ http://purl.uniprot.org/uniprot/A0A096NJJ8 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9555:ADCY9 ^@ http://purl.uniprot.org/uniprot/A0A096NLD9 ^@ Similarity ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. http://togogenome.org/gene/9555:TAF1D ^@ http://purl.uniprot.org/uniprot/A0A096N9Z7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF.|||Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.|||Nucleus http://togogenome.org/gene/9555:GIMD1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NBR3 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9555:PYGM ^@ http://purl.uniprot.org/uniprot/B0CM64 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/9555:PIAS2 ^@ http://purl.uniprot.org/uniprot/A0A096MTN6|||http://purl.uniprot.org/uniprot/A0A096MU31|||http://purl.uniprot.org/uniprot/A0A2I3N4D9 ^@ Similarity ^@ Belongs to the PIAS family. http://togogenome.org/gene/9555:SATB2 ^@ http://purl.uniprot.org/uniprot/A0A096MRX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/9555:KRT13 ^@ http://purl.uniprot.org/uniprot/A0A2I3MTG1 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9555:MTMR2 ^@ http://purl.uniprot.org/uniprot/A0A096N9T1|||http://purl.uniprot.org/uniprot/A0A2I3MBM7|||http://purl.uniprot.org/uniprot/A0A8I5NH28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/9555:FOXO1 ^@ http://purl.uniprot.org/uniprot/A0A096N7B8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9555:NTRK2 ^@ http://purl.uniprot.org/uniprot/A0A096P1W3|||http://purl.uniprot.org/uniprot/A0A2I3MH64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Membrane http://togogenome.org/gene/9555:COQ10A ^@ http://purl.uniprot.org/uniprot/A0A096NH03|||http://purl.uniprot.org/uniprot/A0A2I3MF28 ^@ Function|||Similarity|||Subunit ^@ Belongs to the COQ10 family.|||Interacts with coenzyme Q.|||Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. http://togogenome.org/gene/9555:FZD10 ^@ http://purl.uniprot.org/uniprot/A0A096NAU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:CTSK ^@ http://purl.uniprot.org/uniprot/A0A096NH43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9555:POLR3G ^@ http://purl.uniprot.org/uniprot/A0A096MMV1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPC7 RNA polymerase subunit family.|||Component of the RNA polymerase III (Pol III) complex.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/9555:HACD2 ^@ http://purl.uniprot.org/uniprot/A0A096NFP5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:DNAJC27 ^@ http://purl.uniprot.org/uniprot/A0A2I3M950 ^@ Function|||Subunit ^@ GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.|||Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms). http://togogenome.org/gene/9555:NFIA ^@ http://purl.uniprot.org/uniprot/A0A096MN19|||http://purl.uniprot.org/uniprot/A0A2I3LWJ7|||http://purl.uniprot.org/uniprot/A0A2I3M6D8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTF/NF-I family.|||Binds DNA as a homodimer.|||Nucleus|||Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. http://togogenome.org/gene/9555:ETS1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LSZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:STX2 ^@ http://purl.uniprot.org/uniprot/A0A096MQR1|||http://purl.uniprot.org/uniprot/A0A2I3MK64 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9555:NDST2 ^@ http://purl.uniprot.org/uniprot/A0A096P4L1|||http://purl.uniprot.org/uniprot/A0A8I5N906 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/9555:KDM3B ^@ http://purl.uniprot.org/uniprot/A0A096MS79 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the JHDM2 histone demethylase family.|||Binds 1 Fe(2+) ion per subunit.|||Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.|||Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.|||Nucleus|||The JmjC domain and the C6-type zinc-finger are required for the demethylation activity. http://togogenome.org/gene/9555:CXXC5 ^@ http://purl.uniprot.org/uniprot/A0A096MRR2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:LOC101015460 ^@ http://purl.uniprot.org/uniprot/A0A096N461 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/9555:LIN54 ^@ http://purl.uniprot.org/uniprot/A0A096MVA2|||http://purl.uniprot.org/uniprot/A0A2I3MG28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-54 family.|||Nucleus http://togogenome.org/gene/9555:ATP6V1A ^@ http://purl.uniprot.org/uniprot/A0A096NZ40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Vesicle|||clathrin-coated vesicle membrane|||secretory vesicle http://togogenome.org/gene/9555:ATP5MC2 ^@ http://purl.uniprot.org/uniprot/A0A096MP80 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/9555:CAPN9 ^@ http://purl.uniprot.org/uniprot/A0A096NFY3|||http://purl.uniprot.org/uniprot/A0A2I3MNZ5 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9555:TSEN15 ^@ http://purl.uniprot.org/uniprot/A0A096MLA5|||http://purl.uniprot.org/uniprot/A0A2I3MDL7|||http://purl.uniprot.org/uniprot/A0A8I5MWE1 ^@ Similarity ^@ Belongs to the SEN15 family. http://togogenome.org/gene/9555:PARD3 ^@ http://purl.uniprot.org/uniprot/A0A2I3LI80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAR3 family.|||Cell junction|||Endomembrane system http://togogenome.org/gene/9555:PSMB6 ^@ http://purl.uniprot.org/uniprot/A0A2I3MSP6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:LOC101000269 ^@ http://purl.uniprot.org/uniprot/A9RA98 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:DPYS ^@ http://purl.uniprot.org/uniprot/A0A096MSS6 ^@ PTM|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.|||Carbamylation allows a single lysine to coordinate two divalent metal cations. http://togogenome.org/gene/9555:RGR ^@ http://purl.uniprot.org/uniprot/A0A096P4E1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:GDF10 ^@ http://purl.uniprot.org/uniprot/A0A2I3LVP1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer.|||Secreted http://togogenome.org/gene/9555:CLDN19 ^@ http://purl.uniprot.org/uniprot/A0A2I3N7B2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9555:RTN1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MM18 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:TNFSF13B ^@ http://purl.uniprot.org/uniprot/A0A2I3M5C7 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9555:ACTN2 ^@ http://purl.uniprot.org/uniprot/A0A096N9J6|||http://purl.uniprot.org/uniprot/A0A2I3MJZ3 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/9555:DNASE1L2 ^@ http://purl.uniprot.org/uniprot/A0A096NL30 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/9555:P4HB ^@ http://purl.uniprot.org/uniprot/A0A096NTJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9555:GAL3ST3 ^@ http://purl.uniprot.org/uniprot/A0A096MQE7 ^@ Similarity ^@ Belongs to the galactose-3-O-sulfotransferase family. http://togogenome.org/gene/9555:GALNT6 ^@ http://purl.uniprot.org/uniprot/A0A096N9P7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9555:TULP4 ^@ http://purl.uniprot.org/uniprot/A0A096NDK3 ^@ Similarity ^@ Belongs to the TUB family. http://togogenome.org/gene/9555:LOC101008711 ^@ http://purl.uniprot.org/uniprot/A0A096NEK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:CTDP1 ^@ http://purl.uniprot.org/uniprot/A0A096MTT4 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||This promotes the activity of RNA polymerase II. http://togogenome.org/gene/9555:TAFA5 ^@ http://purl.uniprot.org/uniprot/A0A8I5NJ49|||http://purl.uniprot.org/uniprot/A0A8I5R137 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/9555:BMPR2 ^@ http://purl.uniprot.org/uniprot/A0A096MZD4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. http://togogenome.org/gene/9555:STK10 ^@ http://purl.uniprot.org/uniprot/A0A096N5S6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Cell membrane http://togogenome.org/gene/9555:INO80C ^@ http://purl.uniprot.org/uniprot/A0A2I3LDX8|||http://purl.uniprot.org/uniprot/A0A2I3N7R0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:LOC101012460 ^@ http://purl.uniprot.org/uniprot/A0A096NQI7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCAR/WAVE family.|||Binds actin and the Arp2/3 complex.|||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|||cytoskeleton http://togogenome.org/gene/9555:HNF4G ^@ http://purl.uniprot.org/uniprot/A0A096NFL0|||http://purl.uniprot.org/uniprot/A0A2I3M585 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9555:EPHA1 ^@ http://purl.uniprot.org/uniprot/A0A096NXS5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:PLPPR1 ^@ http://purl.uniprot.org/uniprot/A0A2I3M943 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9555:GTPBP8 ^@ http://purl.uniprot.org/uniprot/A0A2I3LQU0 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. http://togogenome.org/gene/9555:SLC22A5 ^@ http://purl.uniprot.org/uniprot/A0A2I3LL62|||http://purl.uniprot.org/uniprot/A9CB08 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Basal cell membrane|||Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.|||Cell membrane|||Interacts with PDZK1. http://togogenome.org/gene/9555:PARK7 ^@ http://purl.uniprot.org/uniprot/A0A2I3M4I5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C56 family.|||Membrane raft http://togogenome.org/gene/9555:MARK3 ^@ http://purl.uniprot.org/uniprot/A0A096NJY2|||http://purl.uniprot.org/uniprot/A0A2I3LN05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||dendrite http://togogenome.org/gene/9555:VAPA ^@ http://purl.uniprot.org/uniprot/A0A096NDL0|||http://purl.uniprot.org/uniprot/A0A2I3MD21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:YES1 ^@ http://purl.uniprot.org/uniprot/A0A8I5P3Y0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9555:YRDC ^@ http://purl.uniprot.org/uniprot/A0A096MYP7 ^@ Similarity ^@ Belongs to the SUA5 family. http://togogenome.org/gene/9555:C6H6orf120 ^@ http://purl.uniprot.org/uniprot/A0A096MLT1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0669 family.|||May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes.|||Secreted http://togogenome.org/gene/9555:DEFB121 ^@ http://purl.uniprot.org/uniprot/A0A096NV14 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9555:GDPD3 ^@ http://purl.uniprot.org/uniprot/A0A096NHR0 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9555:TMEM184A ^@ http://purl.uniprot.org/uniprot/A0A8I5N993 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:LOC101024147 ^@ http://purl.uniprot.org/uniprot/A0A096MWJ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TTC30/dfy-1/fleer family.|||Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.|||cilium http://togogenome.org/gene/9555:MEF2A ^@ http://purl.uniprot.org/uniprot/A0A2I3N8F7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:ATP5IF1 ^@ http://purl.uniprot.org/uniprot/A0A096NQ00 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase inhibitor family.|||Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.|||Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.|||Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.|||Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.|||Mitochondrion http://togogenome.org/gene/9555:RPL3 ^@ http://purl.uniprot.org/uniprot/A0A096NK57 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/9555:MED22 ^@ http://purl.uniprot.org/uniprot/A0A8I5NPU7 ^@ Function|||Subcellular Location Annotation ^@ Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/9555:PPIA ^@ http://purl.uniprot.org/uniprot/A0A286QUN3|||http://purl.uniprot.org/uniprot/P62941 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization (By similarity). PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition (By similarity). Acetylation at Lys-125 favors the interaction with TARDBP (By similarity).|||Belongs to the cyclophilin-type PPIase family.|||Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.|||Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.|||Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity).|||Cytoplasm|||Interacts with protein phosphatase PPP3CA/calcineurin A (By similarity). Interacts with isoform 2 of BSG/CD147 (By similarity). Interacts with FOXO1; the interaction promotes FOXO1 dephosphorylation, nuclear accumulation and transcriptional activity (By similarity). Interacts with integrin ITGA2B:ITGB3; the interaction is ROS and peptidyl-prolyl cis-trans isomerase (PPIase) activity-dependent and is increased in the presence of thrombin (By similarity). Interacts with MAP3K5 (By similarity). Interacts with TARDBP; the interaction is dependent on the RNA-binding activity of TARDBP and the PPIase activity of PPIA/CYPA and the acetylation of PPIA/CYPA at Lys-125 favors the interaction (By similarity). Interacts with HNRNPA1, HNRNPA2B1, HNRNPC, RBMX, HNRNPK and HNRNPM (By similarity).|||Nucleus|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.|||Secreted http://togogenome.org/gene/9555:WFDC12 ^@ http://purl.uniprot.org/uniprot/A4K2M6 ^@ Function|||Subcellular Location Annotation ^@ Antibacterial protein. Putative acid-stable proteinase inhibitor (By similarity).|||Secreted http://togogenome.org/gene/9555:CBFA2T2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MWJ2 ^@ Similarity ^@ Belongs to the CBFA2T family. http://togogenome.org/gene/9555:ACVR1C ^@ http://purl.uniprot.org/uniprot/A0A096NCC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9555:SMAD7 ^@ http://purl.uniprot.org/uniprot/A0A096MYP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:SLC35A3 ^@ http://purl.uniprot.org/uniprot/A0A096NGD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9555:GSN ^@ http://purl.uniprot.org/uniprot/A0A096P0P7|||http://purl.uniprot.org/uniprot/A0A2I3LIU3|||http://purl.uniprot.org/uniprot/A0A2I3NDQ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the villin/gelsolin family.|||Binds to actin and to fibronectin. Identified in a complex composed of ACTA1, COBL, GSN and TMSB4X. Interacts with the inactive form of EIF2AK2/PKR.|||Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.|||cytoskeleton http://togogenome.org/gene/9555:CPSF4 ^@ http://purl.uniprot.org/uniprot/A0A096N5S3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CPSF4/YTH1 family.|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex.|||Nucleus http://togogenome.org/gene/9555:BET1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NKM0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:SUFU ^@ http://purl.uniprot.org/uniprot/A0A096P6F4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SUFU family.|||Cytoplasm|||Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A).|||Nucleus http://togogenome.org/gene/9555:SMIM18 ^@ http://purl.uniprot.org/uniprot/A0A096NEQ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:MRPL2 ^@ http://purl.uniprot.org/uniprot/A0A096NI98 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/9555:JAGN1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LEM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the jagunal family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:HEXB ^@ http://purl.uniprot.org/uniprot/A0A2I3MDW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 20 family.|||Lysosome http://togogenome.org/gene/9555:FAM210B ^@ http://purl.uniprot.org/uniprot/A0A8I5N617 ^@ Similarity ^@ Belongs to the FAM210 family. http://togogenome.org/gene/9555:TSC22D2 ^@ http://purl.uniprot.org/uniprot/A0A2I3M807 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/9555:LOC101020664 ^@ http://purl.uniprot.org/uniprot/A0A096MPD3 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:ST7 ^@ http://purl.uniprot.org/uniprot/A0A2I3M010|||http://purl.uniprot.org/uniprot/A0A2I3M5X4|||http://purl.uniprot.org/uniprot/A0A2I3N8I0|||http://purl.uniprot.org/uniprot/A0M8R9|||http://purl.uniprot.org/uniprot/A0M8S0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ST7 family.|||Membrane http://togogenome.org/gene/9555:ERC1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LJ26|||http://purl.uniprot.org/uniprot/A0A2I3LPL2|||http://purl.uniprot.org/uniprot/A0A2I3MJ01 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:THAP1 ^@ http://purl.uniprot.org/uniprot/A0A096N1X8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the THAP1 family.|||DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.|||Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.|||nucleoplasm http://togogenome.org/gene/9555:KHDC4 ^@ http://purl.uniprot.org/uniprot/A0A2I3MVU7 ^@ Similarity ^@ Belongs to the KHDC4 family. http://togogenome.org/gene/9555:ASAH2 ^@ http://purl.uniprot.org/uniprot/A0A096P598 ^@ Similarity ^@ Belongs to the neutral ceramidase family. http://togogenome.org/gene/9555:LSM3 ^@ http://purl.uniprot.org/uniprot/A0A096MWN8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/9555:NDFIP1 ^@ http://purl.uniprot.org/uniprot/A0A096MS17 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Membrane http://togogenome.org/gene/9555:BCL9L ^@ http://purl.uniprot.org/uniprot/A0A096MZZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BCL9 family.|||Nucleus http://togogenome.org/gene/9555:SLC13A5 ^@ http://purl.uniprot.org/uniprot/A0A2I3NHF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/9555:HMGN4 ^@ http://purl.uniprot.org/uniprot/A0A8I5NPQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/9555:P3H1 ^@ http://purl.uniprot.org/uniprot/A0A2I3NFN4 ^@ Similarity ^@ Belongs to the leprecan family. http://togogenome.org/gene/9555:LOC101004146 ^@ http://purl.uniprot.org/uniprot/A0A096NE00 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:PKLR ^@ http://purl.uniprot.org/uniprot/A0A2I3LL93 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/9555:ACSF2 ^@ http://purl.uniprot.org/uniprot/A0A096P4I6 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9555:HCFC1 ^@ http://purl.uniprot.org/uniprot/A0A096NAF2|||http://purl.uniprot.org/uniprot/A9CB52 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:YIPF5 ^@ http://purl.uniprot.org/uniprot/A0A096MPL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane http://togogenome.org/gene/9555:ODF2L ^@ http://purl.uniprot.org/uniprot/A0A8I5N9I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ODF2 family.|||centrosome http://togogenome.org/gene/9555:FAM72A ^@ http://purl.uniprot.org/uniprot/A0A2I3NBI7 ^@ Similarity ^@ Belongs to the FAM72 family. http://togogenome.org/gene/9555:DARS1 ^@ http://purl.uniprot.org/uniprot/A0A096MWD1 ^@ Function|||Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. http://togogenome.org/gene/9555:SLC35A2 ^@ http://purl.uniprot.org/uniprot/A0A096MVR1|||http://purl.uniprot.org/uniprot/A0A2I3MXV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9555:MAN1A2 ^@ http://purl.uniprot.org/uniprot/A0A096N6J0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9555:RFC5 ^@ http://purl.uniprot.org/uniprot/A0A096MP38 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/9555:TAF6L ^@ http://purl.uniprot.org/uniprot/A0A096NDU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF6 family.|||Nucleus http://togogenome.org/gene/9555:FARS2 ^@ http://purl.uniprot.org/uniprot/A0A096NKQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Mitochondrion matrix http://togogenome.org/gene/9555:LOC101019598 ^@ http://purl.uniprot.org/uniprot/A0A096MZA0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:LAMTOR4 ^@ http://purl.uniprot.org/uniprot/A0A096MQ77 ^@ Similarity ^@ Belongs to the LAMTOR4 family. http://togogenome.org/gene/9555:RPA3 ^@ http://purl.uniprot.org/uniprot/A0A096MYR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the replication factor A protein 3 family.|||Nucleus http://togogenome.org/gene/9555:SLC7A3 ^@ http://purl.uniprot.org/uniprot/A0A096N745 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:TRIM32 ^@ http://purl.uniprot.org/uniprot/A0A096NE45 ^@ Similarity ^@ Belongs to the TRIM/RBCC family. http://togogenome.org/gene/9555:PIH1D1 ^@ http://purl.uniprot.org/uniprot/A0A0A0MWL4 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/9555:SDAD1 ^@ http://purl.uniprot.org/uniprot/A0A096MX42 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SDA1 family.|||Required for 60S pre-ribosomal subunits export to the cytoplasm.|||nucleolus http://togogenome.org/gene/9555:CARNMT1 ^@ http://purl.uniprot.org/uniprot/A0A096P1T1 ^@ Similarity ^@ Belongs to the carnosine N-methyltransferase family. http://togogenome.org/gene/9555:RHBDL3 ^@ http://purl.uniprot.org/uniprot/A0A2I3LLH7|||http://purl.uniprot.org/uniprot/A0A8I5ND95 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S54 family.|||May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.|||Membrane http://togogenome.org/gene/9555:NIPAL3 ^@ http://purl.uniprot.org/uniprot/A0A096MPY1|||http://purl.uniprot.org/uniprot/A0A2I3N545 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9555:DHRS3 ^@ http://purl.uniprot.org/uniprot/A0A096NRK1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9555:RNF13 ^@ http://purl.uniprot.org/uniprot/A0A096MS08 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:TPD52L1 ^@ http://purl.uniprot.org/uniprot/A0A2I3M5N8|||http://purl.uniprot.org/uniprot/A0A2I3M8G7|||http://purl.uniprot.org/uniprot/A0A2I3MYC9|||http://purl.uniprot.org/uniprot/A0A2I3N3D4|||http://purl.uniprot.org/uniprot/A0A8I5NL03 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/9555:PURA ^@ http://purl.uniprot.org/uniprot/A0A8I5NJD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PUR DNA-binding protein family.|||Nucleus http://togogenome.org/gene/9555:CD59 ^@ http://purl.uniprot.org/uniprot/A0A8I5NBS6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9555:ABCA1 ^@ http://purl.uniprot.org/uniprot/A0A096P0Z3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:NDUFA11 ^@ http://purl.uniprot.org/uniprot/A0A0A0MU92 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA11 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:HDAC6 ^@ http://purl.uniprot.org/uniprot/A0A096N3J9 ^@ Similarity ^@ Belongs to the histone deacetylase family. HD type 2 subfamily. http://togogenome.org/gene/9555:CCS ^@ http://purl.uniprot.org/uniprot/A0A096MMD2 ^@ Similarity ^@ In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family. http://togogenome.org/gene/9555:TOM1L2 ^@ http://purl.uniprot.org/uniprot/A0A096P324|||http://purl.uniprot.org/uniprot/A0A2I3MWX4 ^@ Similarity ^@ Belongs to the TOM1 family. http://togogenome.org/gene/9555:CCDC22 ^@ http://purl.uniprot.org/uniprot/A0A096N9W3 ^@ Similarity ^@ Belongs to the CCDC22 family. http://togogenome.org/gene/9555:AHCYL2 ^@ http://purl.uniprot.org/uniprot/A0A2I3M8L0 ^@ Similarity ^@ Belongs to the adenosylhomocysteinase family. http://togogenome.org/gene/9555:NCEH1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MAK8 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/9555:CRYGD ^@ http://purl.uniprot.org/uniprot/A0A8I5N1H4 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9555:HOXB5 ^@ http://purl.uniprot.org/uniprot/A0A096P425 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9555:CAMK2B ^@ http://purl.uniprot.org/uniprot/A0A2I3MQQ4|||http://purl.uniprot.org/uniprot/A0A2I3NEF7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9555:FIBIN ^@ http://purl.uniprot.org/uniprot/A0A8I5NVN2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FIBIN family.|||Endoplasmic reticulum|||Golgi apparatus|||Homodimer; disulfide-linked. Seems to also exist as monomers.|||Secreted http://togogenome.org/gene/9555:PKIG ^@ http://purl.uniprot.org/uniprot/A0A096NX93 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/9555:HYAL1 ^@ http://purl.uniprot.org/uniprot/A0A096NXR1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/9555:NKAPL ^@ http://purl.uniprot.org/uniprot/A0A8I5NWJ8 ^@ Similarity ^@ Belongs to the NKAP family. http://togogenome.org/gene/9555:TIMP4 ^@ http://purl.uniprot.org/uniprot/A0A096MXC9 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/9555:ZDHHC6 ^@ http://purl.uniprot.org/uniprot/A0A2I3LCU1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Endoplasmic reticulum membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9555:PEX13 ^@ http://purl.uniprot.org/uniprot/A0A096NG93 ^@ Similarity ^@ Belongs to the peroxin-13 family. http://togogenome.org/gene/9555:ASB5 ^@ http://purl.uniprot.org/uniprot/A0A096NQL3|||http://purl.uniprot.org/uniprot/A0A2I3LYV4|||http://purl.uniprot.org/uniprot/A0A8I5NDP9 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9555:ATP5C1 ^@ http://purl.uniprot.org/uniprot/B0CM39 ^@ Function|||Similarity ^@ Belongs to the ATPase gamma chain family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. http://togogenome.org/gene/9555:LYRM4 ^@ http://purl.uniprot.org/uniprot/A0A2I3MAL7 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9555:CCDC149 ^@ http://purl.uniprot.org/uniprot/A0A096NZJ9|||http://purl.uniprot.org/uniprot/A0A2I3MGB1 ^@ Similarity ^@ Belongs to the CCDC149 family. http://togogenome.org/gene/9555:PIGK ^@ http://purl.uniprot.org/uniprot/A0A8I5QZP8 ^@ Similarity|||Subunit ^@ Belongs to the peptidase C13 family.|||Forms a complex with PIGT, PIGS, PIGU and GAA1. http://togogenome.org/gene/9555:CACNA2D3 ^@ http://purl.uniprot.org/uniprot/A0A096N2A4|||http://purl.uniprot.org/uniprot/A0A8I5N7M1 ^@ Similarity ^@ Belongs to the calcium channel subunit alpha-2/delta family. http://togogenome.org/gene/9555:TOMM40L ^@ http://purl.uniprot.org/uniprot/A0A096NBH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom40 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9555:PGM2 ^@ http://purl.uniprot.org/uniprot/A0A096NZM9 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/9555:TOMM5 ^@ http://purl.uniprot.org/uniprot/A0A2I3N161 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom5 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9555:SEC62 ^@ http://purl.uniprot.org/uniprot/A0A096N2E2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC62 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:CHRNA9 ^@ http://purl.uniprot.org/uniprot/A0A8I5NRB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9555:SEZ6 ^@ http://purl.uniprot.org/uniprot/A0A2I3NEZ5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:DEGS1 ^@ http://purl.uniprot.org/uniprot/A0A2I3ND51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:CDK6 ^@ http://purl.uniprot.org/uniprot/A0A096NF27 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:PDE6D ^@ http://purl.uniprot.org/uniprot/A0A2I3LCF7|||http://purl.uniprot.org/uniprot/A0A8I5N535|||http://purl.uniprot.org/uniprot/A0A8I5NP44 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PDE6D/unc-119 family.|||Cytoplasmic vesicle membrane|||Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains and two inhibitory chains; has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane.|||Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.|||cilium basal body|||cytosol http://togogenome.org/gene/9555:SQLE ^@ http://purl.uniprot.org/uniprot/A0A096N5E7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the squalene monooxygenase family.|||Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9555:TM4SF4 ^@ http://purl.uniprot.org/uniprot/A0A096MSZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9555:CDS2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LS38 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Membrane http://togogenome.org/gene/9555:GHR ^@ http://purl.uniprot.org/uniprot/A0A2I3NFX2|||http://purl.uniprot.org/uniprot/A0A2I3NG05|||http://purl.uniprot.org/uniprot/Q9XSZ1 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||Cell membrane|||On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2.|||On growth hormone (GH) binding, forms homodimers and binds JAK2 via a box 1-containing domain. Binding to SOCS3 inhibits JAK2 activation, binding to CIS and SOCS2 inhibits STAT5 activation.|||On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization (By similarity).|||Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity).|||Secreted|||The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.|||The box 1 motif is required for JAK interaction and/or activation.|||The extracellular domain is the ligand-binding domain representing the growth hormone-binding protein (GHBP).|||The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.|||The ubiquitination-dependent endocytosis motif (UbE) is required for recruitment of the ubiquitin conjugation system on to the receptor and for its internalization. http://togogenome.org/gene/9555:MCM6 ^@ http://purl.uniprot.org/uniprot/A0A096NQZ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/9555:GCSH ^@ http://purl.uniprot.org/uniprot/A0A096MV31 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||Mitochondrion|||The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/9555:CCDC85A ^@ http://purl.uniprot.org/uniprot/A0A096N806|||http://purl.uniprot.org/uniprot/A0A2I3MED0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC85 family.|||adherens junction http://togogenome.org/gene/9555:TP53INP1 ^@ http://purl.uniprot.org/uniprot/A0A096NAV6|||http://purl.uniprot.org/uniprot/A0A2I3MK96 ^@ Subcellular Location Annotation ^@ PML body|||autophagosome|||cytosol http://togogenome.org/gene/9555:OSGEP ^@ http://purl.uniprot.org/uniprot/A0A096NNK8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:TMEM11 ^@ http://purl.uniprot.org/uniprot/A0A8I5NBD3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM11 family.|||Membrane|||Plays a role in mitochondrial morphogenesis. http://togogenome.org/gene/9555:LOC101026133 ^@ http://purl.uniprot.org/uniprot/A0A096N224 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. BCS1 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:GSTM3 ^@ http://purl.uniprot.org/uniprot/A0A096N2L3 ^@ Similarity|||Subunit ^@ Belongs to the GST superfamily. Mu family.|||Homodimer. http://togogenome.org/gene/9555:COPG1 ^@ http://purl.uniprot.org/uniprot/A0A096NC40 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPG family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/9555:KCNAB2 ^@ http://purl.uniprot.org/uniprot/A0A8I5N2W4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the shaker potassium channel beta subunit family.|||Cell membrane|||Membrane|||Monomer.|||axon|||cytoskeleton|||synaptosome http://togogenome.org/gene/9555:SLC5A12 ^@ http://purl.uniprot.org/uniprot/A0A096N3Z9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:CLNS1A ^@ http://purl.uniprot.org/uniprot/A0A2I3MM74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pICln (TC 1.A.47) family.|||Nucleus http://togogenome.org/gene/9555:SYP ^@ http://purl.uniprot.org/uniprot/A0A096MN00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/9555:SPSB3 ^@ http://purl.uniprot.org/uniprot/A0A096NKX2 ^@ Function|||Similarity ^@ Belongs to the SPSB family.|||May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/9555:PCK2 ^@ http://purl.uniprot.org/uniprot/A0A096NX64 ^@ Similarity|||Subunit ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.|||Monomer. http://togogenome.org/gene/9555:ZNF24 ^@ http://purl.uniprot.org/uniprot/A0A096N8R3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:NCDN ^@ http://purl.uniprot.org/uniprot/A0A096N7C1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the neurochondrin family.|||Postsynapse http://togogenome.org/gene/9555:ATP6AP1 ^@ http://purl.uniprot.org/uniprot/A9CB63 ^@ Similarity ^@ Belongs to the vacuolar ATPase subunit S1 family. http://togogenome.org/gene/9555:LOC101021712 ^@ http://purl.uniprot.org/uniprot/A0A096MKM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:PPCS ^@ http://purl.uniprot.org/uniprot/A0A2I3MLS6 ^@ Similarity ^@ Belongs to the PPC synthetase family. http://togogenome.org/gene/9555:HPSE ^@ http://purl.uniprot.org/uniprot/A0A096MV72 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 79 family. http://togogenome.org/gene/9555:EDIL3 ^@ http://purl.uniprot.org/uniprot/A0A2I3LZS3|||http://purl.uniprot.org/uniprot/A0A2I3MWI8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:TAAR5 ^@ http://purl.uniprot.org/uniprot/A0A096N6M7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9555:NDUFAF4 ^@ http://purl.uniprot.org/uniprot/A0A8I5N6Z9 ^@ Similarity|||Subunit ^@ Belongs to the NDUFAF4 family.|||Binds calmodulin. Interacts with NDUFAF3. http://togogenome.org/gene/9555:URGCP ^@ http://purl.uniprot.org/uniprot/A0A096NQC7|||http://purl.uniprot.org/uniprot/A0A2I3MGK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.|||Nucleus http://togogenome.org/gene/9555:LOC101009425 ^@ http://purl.uniprot.org/uniprot/A0A096NS15 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/9555:SLC25A43 ^@ http://purl.uniprot.org/uniprot/A0A096NFR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9555:MAPK8IP1 ^@ http://purl.uniprot.org/uniprot/A0A096N4Z0|||http://purl.uniprot.org/uniprot/A0A2I3NGG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JIP scaffold family.|||Cytoplasm http://togogenome.org/gene/9555:LAPTM5 ^@ http://purl.uniprot.org/uniprot/A0A8I5NXX3 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/9555:ADHFE1 ^@ http://purl.uniprot.org/uniprot/A0A8I5R0L7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.|||Mitochondrion http://togogenome.org/gene/9555:XYLB ^@ http://purl.uniprot.org/uniprot/A0A8I5N903 ^@ Function|||Similarity ^@ Belongs to the FGGY kinase family.|||Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis. http://togogenome.org/gene/9555:KNG1 ^@ http://purl.uniprot.org/uniprot/A0A096N7T8 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/9555:PRKAB1 ^@ http://purl.uniprot.org/uniprot/A0A096N4C2 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/9555:EHF ^@ http://purl.uniprot.org/uniprot/A0A096N347 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9555:SPATA20 ^@ http://purl.uniprot.org/uniprot/A0A096P4J6|||http://purl.uniprot.org/uniprot/A0A2I3N544 ^@ Function|||Subcellular Location Annotation ^@ May play a role in fertility regulation.|||Secreted http://togogenome.org/gene/9555:CNPY2 ^@ http://purl.uniprot.org/uniprot/A0A096NH05 ^@ Similarity ^@ Belongs to the canopy family. http://togogenome.org/gene/9555:SNRPB ^@ http://purl.uniprot.org/uniprot/A0A096NV72|||http://purl.uniprot.org/uniprot/A0A2I3LUK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP SmB/SmN family.|||Nucleus http://togogenome.org/gene/9555:INPP5A ^@ http://purl.uniprot.org/uniprot/A0A096NSW7 ^@ Similarity ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family. http://togogenome.org/gene/9555:ELL3 ^@ http://purl.uniprot.org/uniprot/A9X1C1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Nucleus http://togogenome.org/gene/9555:ADPRM ^@ http://purl.uniprot.org/uniprot/A0A096P2Y0 ^@ Similarity|||Subunit ^@ Belongs to the ADPRibase-Mn family.|||Monomer. http://togogenome.org/gene/9555:VDAC3 ^@ http://purl.uniprot.org/uniprot/A0A2I3MAG1 ^@ Similarity ^@ Belongs to the eukaryotic mitochondrial porin family. http://togogenome.org/gene/9555:TRMT1 ^@ http://purl.uniprot.org/uniprot/A0A0A0MX33 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. http://togogenome.org/gene/9555:REEP2 ^@ http://purl.uniprot.org/uniprot/A0A096MZY9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:TNKS ^@ http://purl.uniprot.org/uniprot/A0A096NPS8 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9555:RETREG3 ^@ http://purl.uniprot.org/uniprot/A0A096P5T9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RETREG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:KCNK5 ^@ http://purl.uniprot.org/uniprot/A0A096NHZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9555:NDUFA10 ^@ http://purl.uniprot.org/uniprot/A0A096NPA4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA10 subunit family.|||Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.|||Mitochondrion matrix http://togogenome.org/gene/9555:LOC101020896 ^@ http://purl.uniprot.org/uniprot/A0A2I3MBA7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS26 family. http://togogenome.org/gene/9555:THOC6 ^@ http://purl.uniprot.org/uniprot/A0A096NL98 ^@ Similarity ^@ Belongs to the WD repeat THOC6 family. http://togogenome.org/gene/9555:SFI1 ^@ http://purl.uniprot.org/uniprot/A9CB34 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SFI1 family.|||CETN2-binding regions contains a conserved Trp residue in their C-terminal ends, which seems critical for interaction with CETN2.|||Interacts with CETN2 (via C-terminus).|||It is uncertain whether Met-1 or Met-17 is the initiator.|||Plays a role in the dynamic structure of centrosome-associated contractile fibers via its interaction with CETN2.|||centriole http://togogenome.org/gene/9555:CTBP2 ^@ http://purl.uniprot.org/uniprot/A0A096NU64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Nucleus http://togogenome.org/gene/9555:NSMCE1 ^@ http://purl.uniprot.org/uniprot/A0A096NHI7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NSE1 family.|||Component of the Smc5-Smc6 complex.|||Nucleus|||RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.|||telomere http://togogenome.org/gene/9555:OR51A7 ^@ http://purl.uniprot.org/uniprot/A9L8W1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:UPP1 ^@ http://purl.uniprot.org/uniprot/A0A096MWE5 ^@ Function|||Similarity ^@ Belongs to the PNP/UDP phosphorylase family.|||Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. http://togogenome.org/gene/9555:WWOX ^@ http://purl.uniprot.org/uniprot/A0A096N3N0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm|||Golgi apparatus|||Lysosome|||Mitochondrion http://togogenome.org/gene/9555:TSSK2 ^@ http://purl.uniprot.org/uniprot/A0A8I5R084 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:ACVR1B ^@ http://purl.uniprot.org/uniprot/A0A096NRY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9555:FABP5 ^@ http://purl.uniprot.org/uniprot/A0A096NZ55 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9555:TMEM107 ^@ http://purl.uniprot.org/uniprot/A0A096P2T8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:SERINC5 ^@ http://purl.uniprot.org/uniprot/A0A2I3N5V4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9555:TPM4 ^@ http://purl.uniprot.org/uniprot/A0A2I3LFI5|||http://purl.uniprot.org/uniprot/A0A2I3M5P6|||http://purl.uniprot.org/uniprot/A0A8I5N905 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9555:TBK1 ^@ http://purl.uniprot.org/uniprot/A0A8I5MWP2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:NUF2 ^@ http://purl.uniprot.org/uniprot/A0A096N8R1 ^@ Similarity ^@ Belongs to the NUF2 family. http://togogenome.org/gene/9555:APOC1 ^@ http://purl.uniprot.org/uniprot/A0A096P2H7 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Apolipoprotein C-I is present in acidic (APOC1A) and basic (APOC1B) forms in P.paniscus, P.abelii and P.troglodytes and perhaps also in baboons and macaques. The two genes for ApoC-I arose through a duplication process that occurred after the divergence of New World monkeys from the human lineage. In human, the acidic form has become a pseudogene sometime between the divergence of bonobos and chimpanzees from the human lineage and the appearance of the Denisovans. Pseudogenization resulted when the codon for the penultimate amino acid in the signal sequence was changed to a stop codon.|||Belongs to the apolipoprotein C1 family.|||Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.|||Secreted http://togogenome.org/gene/9555:KHDC3L ^@ http://purl.uniprot.org/uniprot/A9X184 ^@ Similarity ^@ Belongs to the KHDC1 family. http://togogenome.org/gene/9555:NDFIP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3NDB5 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Membrane http://togogenome.org/gene/9555:P2RX4 ^@ http://purl.uniprot.org/uniprot/A0A096MYD1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9555:MAP6D1 ^@ http://purl.uniprot.org/uniprot/A0A096NP99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STOP family.|||cytoskeleton http://togogenome.org/gene/9555:NNMT ^@ http://purl.uniprot.org/uniprot/A0A096NP20 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. http://togogenome.org/gene/9555:NUDT21 ^@ http://purl.uniprot.org/uniprot/A0A096NIH1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family. CPSF5 subfamily.|||Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.|||Cytoplasm|||Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.|||Nucleus http://togogenome.org/gene/9555:LOC101021550 ^@ http://purl.uniprot.org/uniprot/A0A096N132|||http://purl.uniprot.org/uniprot/A0A2I3MCG2|||http://purl.uniprot.org/uniprot/A0A2I3MTF8 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9555:MAPRE1 ^@ http://purl.uniprot.org/uniprot/A0A096NUX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||cytoskeleton http://togogenome.org/gene/9555:XRCC1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LTB7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:USP24 ^@ http://purl.uniprot.org/uniprot/A0A096NA37 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/9555:LOC101001096 ^@ http://purl.uniprot.org/uniprot/A0A096P487|||http://purl.uniprot.org/uniprot/A0A2I3M102|||http://purl.uniprot.org/uniprot/A0A2I3MJY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9555:CTNNB1 ^@ http://purl.uniprot.org/uniprot/A0A8I5R5V9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-catenin family.|||adherens junction http://togogenome.org/gene/9555:GALNT7 ^@ http://purl.uniprot.org/uniprot/A0A096N2H6|||http://purl.uniprot.org/uniprot/A0A2I3MUL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9555:APLNR ^@ http://purl.uniprot.org/uniprot/A0A096MNI3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9555:TXK ^@ http://purl.uniprot.org/uniprot/A0A096NDG3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9555:FAM163B ^@ http://purl.uniprot.org/uniprot/A0A096N6V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM163 family.|||Membrane http://togogenome.org/gene/9555:ADAMTS8 ^@ http://purl.uniprot.org/uniprot/A0A096N1C0 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9555:HADHB ^@ http://purl.uniprot.org/uniprot/A0A2I3MBU6 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/9555:PKP4 ^@ http://purl.uniprot.org/uniprot/A0A096NSL0 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/9555:KRTCAP3 ^@ http://purl.uniprot.org/uniprot/A0A096NWW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM54 family.|||Membrane http://togogenome.org/gene/9555:EFHC1 ^@ http://purl.uniprot.org/uniprot/A0A096NJ42|||http://purl.uniprot.org/uniprot/A0A2I3LPZ2 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9555:AP2M1 ^@ http://purl.uniprot.org/uniprot/A0A096N106|||http://purl.uniprot.org/uniprot/A0A2I3MT63 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cell membrane|||Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.|||coated pit http://togogenome.org/gene/9555:ELAVL4 ^@ http://purl.uniprot.org/uniprot/A0A096MTT3|||http://purl.uniprot.org/uniprot/A0A2I3LD78|||http://purl.uniprot.org/uniprot/A0A2I3MUV9|||http://purl.uniprot.org/uniprot/A0A2I3N449 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM elav family.|||Cytoplasm|||Perikaryon|||axon|||dendrite|||growth cone http://togogenome.org/gene/9555:LOC101016965 ^@ http://purl.uniprot.org/uniprot/A0A8I5NZI5 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9555:DDAH1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LYP1 ^@ Function|||Similarity ^@ Belongs to the DDAH family.|||Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. http://togogenome.org/gene/9555:TPPP2 ^@ http://purl.uniprot.org/uniprot/A0A096NNN5 ^@ Similarity ^@ Belongs to the TPPP family. http://togogenome.org/gene/9555:SULT1B1 ^@ http://purl.uniprot.org/uniprot/A0A096N9E5 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9555:CXCL10 ^@ http://purl.uniprot.org/uniprot/A0A8I5NFY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9555:ANXA3 ^@ http://purl.uniprot.org/uniprot/A0A096NWU5 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9555:RNPS1 ^@ http://purl.uniprot.org/uniprot/A0A096NL34|||http://purl.uniprot.org/uniprot/A0A2I3MGU0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the splicing factor SR family.|||Found in mRNA splicing-dependent exon junction complexes (EJC). Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively; the ASAP and PSAP complexes probably are formed mutually exclusive. Component of the active spliceosome. Associates with polysomes. Interacts with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1 and TRA2B/SFRS10.|||Nucleus speckle http://togogenome.org/gene/9555:LRP3 ^@ http://purl.uniprot.org/uniprot/A0A2I3LK30 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:ELAVL1 ^@ http://purl.uniprot.org/uniprot/A0A096P0K2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM elav family.|||Cytoplasm http://togogenome.org/gene/9555:NOC2L ^@ http://purl.uniprot.org/uniprot/A0A096P2C5|||http://purl.uniprot.org/uniprot/A0A2I3N3R0 ^@ Similarity ^@ Belongs to the NOC2 family. http://togogenome.org/gene/9555:SLC35B3 ^@ http://purl.uniprot.org/uniprot/A0A8I5NIC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/9555:SHMT2 ^@ http://purl.uniprot.org/uniprot/A0A096MNU0 ^@ Function|||Similarity ^@ Belongs to the SHMT family.|||Interconversion of serine and glycine. http://togogenome.org/gene/9555:KCNK16 ^@ http://purl.uniprot.org/uniprot/A0A096NHZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9555:DBNDD2 ^@ http://purl.uniprot.org/uniprot/A4K2M1 ^@ Similarity ^@ Belongs to the dysbindin family. http://togogenome.org/gene/9555:NDST3 ^@ http://purl.uniprot.org/uniprot/A0A2I3M669 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/9555:MRPS33 ^@ http://purl.uniprot.org/uniprot/A0A8I5NAV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS33 family.|||Mitochondrion http://togogenome.org/gene/9555:RECQL5 ^@ http://purl.uniprot.org/uniprot/A0A2I3N6C7 ^@ Similarity ^@ Belongs to the helicase family. RecQ subfamily. http://togogenome.org/gene/9555:CDC14B ^@ http://purl.uniprot.org/uniprot/A0A2I3M7K0|||http://purl.uniprot.org/uniprot/A0A2I3MUA9 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily. http://togogenome.org/gene/9555:MTMR9 ^@ http://purl.uniprot.org/uniprot/A0A096MTA4 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9555:SLC25A25 ^@ http://purl.uniprot.org/uniprot/A0A096P1Y7|||http://purl.uniprot.org/uniprot/A0A2I3LFT5|||http://purl.uniprot.org/uniprot/A0A2I3LHU5|||http://purl.uniprot.org/uniprot/A0A2I3N1G5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:PPIL1 ^@ http://purl.uniprot.org/uniprot/A0A8I5R0F3 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9555:PSMB5 ^@ http://purl.uniprot.org/uniprot/A0A096NRC4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:CD74 ^@ http://purl.uniprot.org/uniprot/A0A096MM48 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:ST6GALNAC3 ^@ http://purl.uniprot.org/uniprot/A0A096MLX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9555:PPP1R14D ^@ http://purl.uniprot.org/uniprot/A0A096NTI9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PP1 inhibitor family.|||Cytoplasm|||Inhibitor of PPP1CA. http://togogenome.org/gene/9555:SNCB ^@ http://purl.uniprot.org/uniprot/A0A8I5NA40 ^@ Similarity ^@ Belongs to the synuclein family. http://togogenome.org/gene/9555:C9H12orf57 ^@ http://purl.uniprot.org/uniprot/A0A096MUX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0456 family.|||Cytoplasm http://togogenome.org/gene/9555:FBXO25 ^@ http://purl.uniprot.org/uniprot/A0A096N939|||http://purl.uniprot.org/uniprot/A0A2I3MGB8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:PCMTD2 ^@ http://purl.uniprot.org/uniprot/A0A096NN23 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/9555:CLEC12B ^@ http://purl.uniprot.org/uniprot/A0A096MQX7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9555:GMPR ^@ http://purl.uniprot.org/uniprot/A0A2I3MCL4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.|||Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.|||Homotetramer. http://togogenome.org/gene/9555:PITX2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NLJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9555:GUCA2B ^@ http://purl.uniprot.org/uniprot/A0A096MT23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylin family.|||Secreted http://togogenome.org/gene/9555:NCBP1 ^@ http://purl.uniprot.org/uniprot/A0A096P136 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NCBP1 family.|||Nucleus http://togogenome.org/gene/9555:ATG13 ^@ http://purl.uniprot.org/uniprot/A0A096MWG3|||http://purl.uniprot.org/uniprot/A0A096NFX1|||http://purl.uniprot.org/uniprot/A0A2I3LSG8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.|||Belongs to the ATG13 family. Metazoan subfamily.|||Preautophagosomal structure http://togogenome.org/gene/9555:CLDN10 ^@ http://purl.uniprot.org/uniprot/A0A2I3LVC2|||http://purl.uniprot.org/uniprot/A0A8I5NL42 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9555:PRORP ^@ http://purl.uniprot.org/uniprot/A0A2I3N6V4 ^@ Similarity ^@ Belongs to the PPR family. P subfamily. http://togogenome.org/gene/9555:ENTPD1 ^@ http://purl.uniprot.org/uniprot/A0A096P5S5|||http://purl.uniprot.org/uniprot/A0A2I3MWL5 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9555:SDHAF2 ^@ http://purl.uniprot.org/uniprot/A0A096NGZ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SDHAF2 family.|||Interacts with SDHA within the SDH catalytic dimer.|||Mitochondrion matrix|||Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. http://togogenome.org/gene/9555:LOC101001218 ^@ http://purl.uniprot.org/uniprot/A0A2I3M8F3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:FAM124A ^@ http://purl.uniprot.org/uniprot/A0A096NP22 ^@ Similarity ^@ Belongs to the FAM124 family. http://togogenome.org/gene/9555:UGT1A6 ^@ http://purl.uniprot.org/uniprot/Q20CL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9555:FIP1L1 ^@ http://purl.uniprot.org/uniprot/A0A096NBS8|||http://purl.uniprot.org/uniprot/A0A2I3MG99|||http://purl.uniprot.org/uniprot/A0A2I3N964 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FIP1 family.|||Nucleus http://togogenome.org/gene/9555:AGXT ^@ http://purl.uniprot.org/uniprot/A0A096NXK3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||Peroxisome http://togogenome.org/gene/9555:MMP13 ^@ http://purl.uniprot.org/uniprot/A0A2I3LXK6 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9555:RAB4B ^@ http://purl.uniprot.org/uniprot/A0A0A0MVM9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. http://togogenome.org/gene/9555:NCK2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NIW6 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Endoplasmic reticulum http://togogenome.org/gene/9555:WNT7A ^@ http://purl.uniprot.org/uniprot/A0A8I5NIJ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9555:JRK ^@ http://purl.uniprot.org/uniprot/A0A096MR45|||http://purl.uniprot.org/uniprot/A0A2I3N3X7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:OSM ^@ http://purl.uniprot.org/uniprot/A0A096NJG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LIF/OSM family.|||Secreted http://togogenome.org/gene/9555:ETHE1 ^@ http://purl.uniprot.org/uniprot/A0A0A0MV56 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. http://togogenome.org/gene/9555:TMTC4 ^@ http://purl.uniprot.org/uniprot/A0A096N665 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/9555:ZNF830 ^@ http://purl.uniprot.org/uniprot/A0A096P3U7 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus speckle http://togogenome.org/gene/9555:PYGL ^@ http://purl.uniprot.org/uniprot/A0A096NUY6 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/9555:HEXIM1 ^@ http://purl.uniprot.org/uniprot/A0A096NCL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HEXIM family.|||Nucleus http://togogenome.org/gene/9555:RFPL1 ^@ http://purl.uniprot.org/uniprot/A0A096NJD7|||http://purl.uniprot.org/uniprot/A9CB40 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:PGAP2 ^@ http://purl.uniprot.org/uniprot/A0A096MMB3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PGAP2 family.|||Interacts with PGAP2IP.|||Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface.|||Membrane http://togogenome.org/gene/9555:MPP6 ^@ http://purl.uniprot.org/uniprot/A0A096NW04|||http://purl.uniprot.org/uniprot/A0A2I3LY71 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/9555:PLA2G15 ^@ http://purl.uniprot.org/uniprot/A0A096NZP4 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9555:TMSB10 ^@ http://purl.uniprot.org/uniprot/A0A8I5NMH4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/9555:GALNT16 ^@ http://purl.uniprot.org/uniprot/A0A096NVU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9555:C1RL ^@ http://purl.uniprot.org/uniprot/A0A2I3MT71 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:ACTG1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MH20 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9555:SPSB1 ^@ http://purl.uniprot.org/uniprot/A0A2I3N993 ^@ Similarity ^@ Belongs to the SPSB family. http://togogenome.org/gene/9555:ITM2C ^@ http://purl.uniprot.org/uniprot/A0A2I3NI05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITM2 family.|||Membrane http://togogenome.org/gene/9555:XPOT ^@ http://purl.uniprot.org/uniprot/A0A096MU72 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus|||tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. http://togogenome.org/gene/9555:OSBPL1A ^@ http://purl.uniprot.org/uniprot/A0A096NFH2 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9555:DDX6 ^@ http://purl.uniprot.org/uniprot/A0A096MW74 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9555:CLDN14 ^@ http://purl.uniprot.org/uniprot/A0A096N9S6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9555:RPL39L ^@ http://purl.uniprot.org/uniprot/A0A8I5P2H5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/9555:MRPL32 ^@ http://purl.uniprot.org/uniprot/A0A096NG95 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/9555:MRPL1 ^@ http://purl.uniprot.org/uniprot/A0A096MSA0|||http://purl.uniprot.org/uniprot/A0A8I5N3T9 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9555:PON1 ^@ http://purl.uniprot.org/uniprot/A0A096MTS0 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit.|||Glycosylated. http://togogenome.org/gene/9555:CDK2AP1 ^@ http://purl.uniprot.org/uniprot/A0A096NXI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDK2AP family.|||Nucleus http://togogenome.org/gene/9555:LOC101020077 ^@ http://purl.uniprot.org/uniprot/A0A2I3MLD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYBC1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:CERS3 ^@ http://purl.uniprot.org/uniprot/A0A096NNE7 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9555:SYBU ^@ http://purl.uniprot.org/uniprot/A0A096MYQ0|||http://purl.uniprot.org/uniprot/A0A2I3LI13|||http://purl.uniprot.org/uniprot/A0A8I5NHS4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:PMM2 ^@ http://purl.uniprot.org/uniprot/A0A096NLL4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic PMM family.|||Cytoplasm|||Homodimer.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/9555:HOXB7 ^@ http://purl.uniprot.org/uniprot/A0A8I5N170 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9555:LOC100998247 ^@ http://purl.uniprot.org/uniprot/A0A096P5L4 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9555:NUBP1 ^@ http://purl.uniprot.org/uniprot/A0A096NLN5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.|||Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.|||Cell projection|||Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.|||Cytoplasm|||Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1. http://togogenome.org/gene/9555:CPT2 ^@ http://purl.uniprot.org/uniprot/A0A096NY67 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/9555:EMC3 ^@ http://purl.uniprot.org/uniprot/A0A096NH37 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC3 family.|||Component of the ER membrane protein complex (EMC).|||Membrane http://togogenome.org/gene/9555:CCN3 ^@ http://purl.uniprot.org/uniprot/A0A096MUT5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9555:LOC101019886 ^@ http://purl.uniprot.org/uniprot/A0A096P4X8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.|||Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. http://togogenome.org/gene/9555:APEX2 ^@ http://purl.uniprot.org/uniprot/A0A096N3Q5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Cytoplasm|||Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.|||Mitochondrion|||Nucleus|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/9555:LAMTOR2 ^@ http://purl.uniprot.org/uniprot/A0A2I3NIK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GAMAD family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/9555:FAM98C ^@ http://purl.uniprot.org/uniprot/A0A0A0MWC4 ^@ Similarity ^@ Belongs to the FAM98 family. http://togogenome.org/gene/9555:TAF7 ^@ http://purl.uniprot.org/uniprot/A0A8I5NME3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF7 family.|||Nucleus http://togogenome.org/gene/9555:LYPLAL1 ^@ http://purl.uniprot.org/uniprot/A0A096MMW1 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/9555:LOC108583710 ^@ http://purl.uniprot.org/uniprot/A0A096NE90 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Component of the 40S small ribosomal subunit. http://togogenome.org/gene/9555:PSMA5 ^@ http://purl.uniprot.org/uniprot/A0A096MPG3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9555:S100B ^@ http://purl.uniprot.org/uniprot/A0A8I5N4X8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the S-100 family.|||Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/9555:GRHL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3ND43 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:LOC108581327 ^@ http://purl.uniprot.org/uniprot/A0A096N461 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/9555:METTL2A ^@ http://purl.uniprot.org/uniprot/A0A096P6B0 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/9555:RPS4X ^@ http://purl.uniprot.org/uniprot/A0A096MLU8|||http://purl.uniprot.org/uniprot/A9CB07 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/9555:CDK5R2 ^@ http://purl.uniprot.org/uniprot/A0A096N9X6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cyclin-dependent kinase 5 activator family.|||Cell membrane|||Heterodimer of a catalytic subunit and a regulatory subunit.|||Membrane http://togogenome.org/gene/9555:LIPM ^@ http://purl.uniprot.org/uniprot/A0A096P5D1 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9555:DIPK2A ^@ http://purl.uniprot.org/uniprot/A0A8I5R538 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Secreted http://togogenome.org/gene/9555:ZDHHC22 ^@ http://purl.uniprot.org/uniprot/A0A096NS74 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9555:CD247 ^@ http://purl.uniprot.org/uniprot/Q09TK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD3Z/FCER1G family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:SLC2A1 ^@ http://purl.uniprot.org/uniprot/D3VYT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Cell membrane|||Membrane|||Photoreceptor inner segment http://togogenome.org/gene/9555:RPS27 ^@ http://purl.uniprot.org/uniprot/A0A2I3NEH1 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9555:NR2C2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LFG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9555:OAZ2 ^@ http://purl.uniprot.org/uniprot/A0A096NMC1 ^@ Similarity ^@ Belongs to the ODC antizyme family. http://togogenome.org/gene/9555:ST8SIA2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LKH1|||http://purl.uniprot.org/uniprot/A0A8I5NF01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9555:NME3 ^@ http://purl.uniprot.org/uniprot/A0A096NKW8 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9555:PARD6B ^@ http://purl.uniprot.org/uniprot/A0A096NNP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAR6 family.|||Cytoplasm|||tight junction http://togogenome.org/gene/9555:NOP56 ^@ http://purl.uniprot.org/uniprot/A0A096NV77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP5/NOP56 family.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9555:YWHAQ ^@ http://purl.uniprot.org/uniprot/A0A096NIX1 ^@ Function|||Similarity ^@ Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.|||Belongs to the 14-3-3 family. http://togogenome.org/gene/9555:TLCD1 ^@ http://purl.uniprot.org/uniprot/A0A096P3C1|||http://purl.uniprot.org/uniprot/A0A2I3N6Q0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:GRIN1 ^@ http://purl.uniprot.org/uniprot/A0A096NWP3|||http://purl.uniprot.org/uniprot/A0A2I3LFD2|||http://purl.uniprot.org/uniprot/A0A2I3MHC7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/9555:LPCAT3 ^@ http://purl.uniprot.org/uniprot/A0A096MST4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:DNM1L ^@ http://purl.uniprot.org/uniprot/A0A2I3MNT3 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/9555:LRRFIP2 ^@ http://purl.uniprot.org/uniprot/A0A096MTG7|||http://purl.uniprot.org/uniprot/A0A2I3LE62|||http://purl.uniprot.org/uniprot/A0A2I3MAD1 ^@ Similarity ^@ Belongs to the LRRFIP family. http://togogenome.org/gene/9555:SNX2 ^@ http://purl.uniprot.org/uniprot/A0A096MY55|||http://purl.uniprot.org/uniprot/A0A8I5N831 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome membrane|||Endosome membrane|||Membrane|||lamellipodium http://togogenome.org/gene/9555:EDA2R ^@ http://purl.uniprot.org/uniprot/A0A096MRD7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:ABCG2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NFF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/9555:SLAIN1 ^@ http://purl.uniprot.org/uniprot/A0A096NFD2|||http://purl.uniprot.org/uniprot/A0A2I3LNI3|||http://purl.uniprot.org/uniprot/A0A2I3MC79|||http://purl.uniprot.org/uniprot/A0A2I3NG70 ^@ Similarity ^@ Belongs to the SLAIN motif-containing family. http://togogenome.org/gene/9555:MORF4L1 ^@ http://purl.uniprot.org/uniprot/A0A096NMW6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:ERCC1 ^@ http://purl.uniprot.org/uniprot/A0A2I3NAT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERCC1/RAD10/SWI10 family.|||Nucleus http://togogenome.org/gene/9555:HPSE2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LF58 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 79 family. http://togogenome.org/gene/9555:WDR76 ^@ http://purl.uniprot.org/uniprot/A9X1C6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the WD repeat DDB2/WDR76 family.|||Interacts with CUL4A and/or CUL4B.|||Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. http://togogenome.org/gene/9555:ACAD9 ^@ http://purl.uniprot.org/uniprot/A0A096N6M0 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9555:RTF2 ^@ http://purl.uniprot.org/uniprot/A0A096NNJ7 ^@ Similarity|||Subunit ^@ Belongs to the rtf2 family.|||Interacts with DDI2; probably also interacts with DDI1. http://togogenome.org/gene/9555:NAP1L3 ^@ http://purl.uniprot.org/uniprot/A0A096N3Z7 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9555:SYNGR2 ^@ http://purl.uniprot.org/uniprot/A0A096NT64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptogyrin family.|||Membrane http://togogenome.org/gene/9555:LOC108587426 ^@ http://purl.uniprot.org/uniprot/A0A096NCX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9555:FADS2 ^@ http://purl.uniprot.org/uniprot/B8R1K0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Endoplasmic reticulum membrane|||Involved in the biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively (By similarity). Subsequently, in the biosynthetic pathway of HUFA n-3 series, it desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function (By similarity). It can also desaturate (11E)-octadecenoate (trans-vaccenoate) at carbon 6 generating (6Z,11E)-octadecadienoate (By similarity). In addition to Delta-6 activity, this enzyme exhibits Delta-8 activity with slight biases toward n-3 fatty acyl-CoA substrates (PubMed:19202133).|||The protein sequence includes a number of characteristic features of microsomal fatty acid desaturases including the three histidine boxes HXXXH, HXXHH, and QXXHH (these domains may contain the active site and/or be involved in metal ion binding), and the N-terminal cytochrome b5 domain containing the heme-binding motif, HPGG, similar to that of other fatty acid desaturases. http://togogenome.org/gene/9555:ETS2 ^@ http://purl.uniprot.org/uniprot/A0A096NJ28 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus|||Transcription factor. http://togogenome.org/gene/9555:INIP ^@ http://purl.uniprot.org/uniprot/A0A8I5NKJ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SOSS-C family.|||Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).|||Component of the SOSS complex.|||Nucleus http://togogenome.org/gene/9555:FLVCR1 ^@ http://purl.uniprot.org/uniprot/A0A096NNZ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:CTNND1 ^@ http://purl.uniprot.org/uniprot/A0A096N842|||http://purl.uniprot.org/uniprot/A0A2I3MLV7|||http://purl.uniprot.org/uniprot/A0A2I3ND60 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/9555:GDF6 ^@ http://purl.uniprot.org/uniprot/A0A096MW46 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9555:LOC101004599 ^@ http://purl.uniprot.org/uniprot/A0A2I3LN37 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.|||Forms a homohexamer that can probably bind six kinase subunits. http://togogenome.org/gene/9555:C5H5orf24 ^@ http://purl.uniprot.org/uniprot/A0A096MLK9 ^@ Similarity ^@ Belongs to the UPF0461 family. http://togogenome.org/gene/9555:IL1RL1 ^@ http://purl.uniprot.org/uniprot/A0A096MQK8 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9555:TNNT2 ^@ http://purl.uniprot.org/uniprot/A0A096MLA8|||http://purl.uniprot.org/uniprot/A0A096MMI7|||http://purl.uniprot.org/uniprot/A0A2I3LXC3 ^@ Function|||Similarity ^@ Belongs to the troponin T family.|||Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. http://togogenome.org/gene/9555:CHRNA7 ^@ http://purl.uniprot.org/uniprot/A0A096NT59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9555:CLIC5 ^@ http://purl.uniprot.org/uniprot/A0A8I5R2D7 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/9555:FTH1 ^@ http://purl.uniprot.org/uniprot/A0A096MPD7 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/9555:LOC101019021 ^@ http://purl.uniprot.org/uniprot/A0A2I3MRT7 ^@ Similarity ^@ Belongs to the MORF4 family-associated protein family. http://togogenome.org/gene/9555:LOC101008081 ^@ http://purl.uniprot.org/uniprot/A0A8I5N8V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:MRPL18 ^@ http://purl.uniprot.org/uniprot/A0A096NZS4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL18 family. http://togogenome.org/gene/9555:TERF1 ^@ http://purl.uniprot.org/uniprot/A0A096MMA6|||http://purl.uniprot.org/uniprot/A0A096NQ73 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.|||Homodimer.|||Nucleus|||telomere http://togogenome.org/gene/9555:TRIM35 ^@ http://purl.uniprot.org/uniprot/A0A096NQI3 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9555:KRT10 ^@ http://purl.uniprot.org/uniprot/A0A096P5I5 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9555:CCDC85B ^@ http://purl.uniprot.org/uniprot/A0A096N9K3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC85 family.|||adherens junction http://togogenome.org/gene/9555:PPIE ^@ http://purl.uniprot.org/uniprot/A0A096N9N0 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.|||Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. http://togogenome.org/gene/9555:RAB39A ^@ http://purl.uniprot.org/uniprot/A0A8I5R5M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:NGB ^@ http://purl.uniprot.org/uniprot/A0A8I5NP85 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9555:S100A16 ^@ http://purl.uniprot.org/uniprot/A0A8I5NT38 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9555:RPL34 ^@ http://purl.uniprot.org/uniprot/A0A2I3NI01 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/9555:ASF1B ^@ http://purl.uniprot.org/uniprot/A0A2I3M8T6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/9555:HAO2 ^@ http://purl.uniprot.org/uniprot/A0A096N489|||http://purl.uniprot.org/uniprot/A0A2I3LSG5 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/9555:DDX43 ^@ http://purl.uniprot.org/uniprot/A9X186 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9555:PSMA8 ^@ http://purl.uniprot.org/uniprot/A0A096N493 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9555:SCUBE3 ^@ http://purl.uniprot.org/uniprot/A0A096NHM9|||http://purl.uniprot.org/uniprot/A0A2I3MP95 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9555:SLC16A8 ^@ http://purl.uniprot.org/uniprot/A0A096NK08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/9555:MICOS10 ^@ http://purl.uniprot.org/uniprot/A0A096NBM3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic10 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:SLA2 ^@ http://purl.uniprot.org/uniprot/A0A096NUK2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:RBCK1 ^@ http://purl.uniprot.org/uniprot/A0A2I3M7Q1|||http://purl.uniprot.org/uniprot/A0A2I3NAG5 ^@ Similarity ^@ Belongs to the RBR family. http://togogenome.org/gene/9555:PTAR1 ^@ http://purl.uniprot.org/uniprot/A0A8I5N175|||http://purl.uniprot.org/uniprot/A0A8I5NQH1 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family. http://togogenome.org/gene/9555:GPR141 ^@ http://purl.uniprot.org/uniprot/A0A096NBJ4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9555:CPSF3 ^@ http://purl.uniprot.org/uniprot/A0A096NIU8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:LOC101009150 ^@ http://purl.uniprot.org/uniprot/A0A8I5N5H0 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/9555:GTF2H5 ^@ http://purl.uniprot.org/uniprot/A0A8I5NN96 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB5 family.|||Component of the 7-subunit TFIIH core complex.|||In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.|||Nucleus http://togogenome.org/gene/9555:KCNJ2 ^@ http://purl.uniprot.org/uniprot/A0A096MS42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.|||Membrane http://togogenome.org/gene/9555:FGF18 ^@ http://purl.uniprot.org/uniprot/A0A096NRK9 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9555:TM9SF1 ^@ http://purl.uniprot.org/uniprot/A0A096NXA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/9555:PSMB9 ^@ http://purl.uniprot.org/uniprot/A0A2I3M6S9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:KCNMA1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LW41|||http://purl.uniprot.org/uniprot/A0A2I3M8Q1|||http://purl.uniprot.org/uniprot/A0A2I3MMI8|||http://purl.uniprot.org/uniprot/A0A2I3N4E5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.|||Membrane http://togogenome.org/gene/9555:SLC26A2 ^@ http://purl.uniprot.org/uniprot/A0A096MRQ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane|||Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development. Mediates electroneutral anion exchange of sulfate ions for oxalate ions, sulfate and oxalate ions for chloride and/or hydroxyl ions and chloride ions for bromide, iodide and nitrate ions. The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange. Essential for chondrocyte proliferation, differentiation and cell size expansion. http://togogenome.org/gene/9555:CYTB ^@ http://purl.uniprot.org/uniprot/C6FE41 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome b family.|||Binds 2 heme groups non-covalently.|||Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.|||Membrane|||Mitochondrion inner membrane|||The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer. http://togogenome.org/gene/9555:WASHC3 ^@ http://purl.uniprot.org/uniprot/A0A096MU01|||http://purl.uniprot.org/uniprot/A0A8I5N220 ^@ Similarity ^@ Belongs to the CCDC53 family. http://togogenome.org/gene/9555:CENPQ ^@ http://purl.uniprot.org/uniprot/A0A096NIZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-Q/OKP1 family.|||Nucleus http://togogenome.org/gene/9555:KIF1C ^@ http://purl.uniprot.org/uniprot/A0A096P2J3 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9555:RASGRP2 ^@ http://purl.uniprot.org/uniprot/B0CM63 ^@ Similarity ^@ Belongs to the RASGRP family. http://togogenome.org/gene/9555:MRPL44 ^@ http://purl.uniprot.org/uniprot/A0A2I3LF84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.|||Mitochondrion http://togogenome.org/gene/9555:LOC101021397 ^@ http://purl.uniprot.org/uniprot/A0A8I5NVF4 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme c group covalently per subunit.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:LITAF ^@ http://purl.uniprot.org/uniprot/A0A2I3M8U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/9555:TOLLIP ^@ http://purl.uniprot.org/uniprot/A0A096MQQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tollip family.|||Cytoplasm http://togogenome.org/gene/9555:TRAPPC6B ^@ http://purl.uniprot.org/uniprot/A0A2I3N1E5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||cis-Golgi network http://togogenome.org/gene/9555:PIP4P2 ^@ http://purl.uniprot.org/uniprot/A0A096NBF4 ^@ Function|||Subcellular Location Annotation ^@ Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane|||phagosome membrane http://togogenome.org/gene/9555:TAZ ^@ http://purl.uniprot.org/uniprot/A9CB62 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis.|||Associates with multiple protein complexes.|||Belongs to the taffazin family.|||Mitochondrion inner membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9555:STARD6 ^@ http://purl.uniprot.org/uniprot/A0A2I3MJY8 ^@ Function ^@ May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols. http://togogenome.org/gene/9555:ADAM2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MIV8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:LOC100998508 ^@ http://purl.uniprot.org/uniprot/A0A8I5NMX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9555:RBPJ ^@ http://purl.uniprot.org/uniprot/A0A2I3N1M1|||http://purl.uniprot.org/uniprot/A0A8I5NU76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Su(H) family.|||Nucleus http://togogenome.org/gene/9555:MFSD3 ^@ http://purl.uniprot.org/uniprot/A0A096N3E3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:RNF40 ^@ http://purl.uniprot.org/uniprot/A0A096NHV5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BRE1 family.|||Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.|||Nucleus http://togogenome.org/gene/9555:GMDS ^@ http://purl.uniprot.org/uniprot/A0A8I5N4M8 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. http://togogenome.org/gene/9555:THYN1 ^@ http://purl.uniprot.org/uniprot/A0A096N7J7 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. http://togogenome.org/gene/9555:PON2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LH95 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit.|||Glycosylated. http://togogenome.org/gene/9555:TMEM45A ^@ http://purl.uniprot.org/uniprot/A0A096MYN6|||http://purl.uniprot.org/uniprot/A0A2I3MKD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/9555:RASGRP3 ^@ http://purl.uniprot.org/uniprot/A0A8I5N5V4 ^@ Similarity ^@ Belongs to the RASGRP family. http://togogenome.org/gene/9555:LOC101021285 ^@ http://purl.uniprot.org/uniprot/A0A096P3X8 ^@ Function|||Similarity ^@ Belongs to the glycosyl hydrolase 22 family.|||Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. http://togogenome.org/gene/9555:ECHDC1 ^@ http://purl.uniprot.org/uniprot/A0A096MV85|||http://purl.uniprot.org/uniprot/A0A2I3MS70 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9555:ANKRD13B ^@ http://purl.uniprot.org/uniprot/A0A096P3K4 ^@ Function|||Subcellular Location Annotation ^@ Endosome|||Late endosome|||Membrane|||Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. http://togogenome.org/gene/9555:TMEM242 ^@ http://purl.uniprot.org/uniprot/A0A8I5P2V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM242 family.|||Membrane http://togogenome.org/gene/9555:STX5 ^@ http://purl.uniprot.org/uniprot/A0A096NGZ5 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9555:WDR55 ^@ http://purl.uniprot.org/uniprot/A0A096N9H9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR55 family.|||Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis.|||nucleolus http://togogenome.org/gene/9555:PIM2 ^@ http://purl.uniprot.org/uniprot/A0A096N047 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.|||Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. http://togogenome.org/gene/9555:KIF11 ^@ http://purl.uniprot.org/uniprot/A0A096P5L9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.|||spindle pole http://togogenome.org/gene/9555:STARD3NL ^@ http://purl.uniprot.org/uniprot/A0A096NQX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STARD3 family.|||Membrane http://togogenome.org/gene/9555:NUP133 ^@ http://purl.uniprot.org/uniprot/A0A096NXJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin Nup133 family.|||nuclear pore complex http://togogenome.org/gene/9555:LOC101017122 ^@ http://purl.uniprot.org/uniprot/A0A2I3MDY9 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/9555:LOC101024162 ^@ http://purl.uniprot.org/uniprot/A0A096NSK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX17 family.|||Mitochondrion intermembrane space http://togogenome.org/gene/9555:PREB ^@ http://purl.uniprot.org/uniprot/A0A2I3LWL4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat SEC12 family.|||Endoplasmic reticulum membrane|||Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.|||Interacts with SAR1B (GDP-bound form). Interacts with MIA2; recruits PREB to endoplasmic reticulum exit sites.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription. http://togogenome.org/gene/9555:GPR1 ^@ http://purl.uniprot.org/uniprot/A0A096NCE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:PRRX1 ^@ http://purl.uniprot.org/uniprot/A0A096MLS8|||http://purl.uniprot.org/uniprot/A0A2I3N9P5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/9555:GATM ^@ http://purl.uniprot.org/uniprot/A0A096NLZ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the amidinotransferase family.|||Homodimer.|||Mitochondrion inner membrane|||Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives. Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain. http://togogenome.org/gene/9555:TRUB1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NIM5 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/9555:CNTN2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MMP4 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. Contactin family. http://togogenome.org/gene/9555:NACC1 ^@ http://purl.uniprot.org/uniprot/A0A0A0MUH9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:THTPA ^@ http://purl.uniprot.org/uniprot/A0A2I3NDE5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ThTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Hydrolase highly specific for thiamine triphosphate (ThTP).|||Monomer. http://togogenome.org/gene/9555:TAX1BP3 ^@ http://purl.uniprot.org/uniprot/A0A096P2E5 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Cytoplasm|||May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.|||Nucleus http://togogenome.org/gene/9555:BCKDK ^@ http://purl.uniprot.org/uniprot/A0A096NHX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9555:ST6GAL2 ^@ http://purl.uniprot.org/uniprot/A0A096N576 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Golgi stack membrane|||Membrane|||Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids. http://togogenome.org/gene/9555:NDRG2 ^@ http://purl.uniprot.org/uniprot/A0A096NNN1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDRG family.|||Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.|||Cytoplasm http://togogenome.org/gene/9555:SPOP ^@ http://purl.uniprot.org/uniprot/A0A096P456 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tdpoz family.|||Nucleus speckle http://togogenome.org/gene/9555:RNASE9 ^@ http://purl.uniprot.org/uniprot/Q863J8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pancreatic ribonuclease family.|||Does not exhibit any ribonuclease activity.|||Secreted http://togogenome.org/gene/9555:RCL1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NSN9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.|||Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.|||nucleolus http://togogenome.org/gene/9555:XPA ^@ http://purl.uniprot.org/uniprot/A0A096P135|||http://purl.uniprot.org/uniprot/A0A8I5N6V4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPA family.|||Nucleus http://togogenome.org/gene/9555:OR51M1 ^@ http://purl.uniprot.org/uniprot/A9L8Y4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:RBX1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NLP6 ^@ Similarity ^@ Belongs to the RING-box family. http://togogenome.org/gene/9555:DMGDH ^@ http://purl.uniprot.org/uniprot/A0A096MVD4 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/9555:SGCB ^@ http://purl.uniprot.org/uniprot/A0A096NZ38 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.|||Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/9555:CABS1 ^@ http://purl.uniprot.org/uniprot/A0A8I5R218 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Membrane|||Mitochondrion inner membrane|||flagellum http://togogenome.org/gene/9555:GLO1 ^@ http://purl.uniprot.org/uniprot/A0A096NHX0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the glyoxalase I family.|||Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.|||Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. http://togogenome.org/gene/9555:SLC5A5 ^@ http://purl.uniprot.org/uniprot/A0A0A0MX32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:HS3ST2 ^@ http://purl.uniprot.org/uniprot/A0A8I5QZE5 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9555:PRDM13 ^@ http://purl.uniprot.org/uniprot/A0A096NF46 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:PPAN ^@ http://purl.uniprot.org/uniprot/A0A096N908 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9555:BMP7 ^@ http://purl.uniprot.org/uniprot/A0A096NNJ3 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9555:SLC31A2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MLY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9555:FAM166C ^@ http://purl.uniprot.org/uniprot/A0A8I5NEG9 ^@ Similarity ^@ Belongs to the CIMIP2 family. http://togogenome.org/gene/9555:GABRE ^@ http://purl.uniprot.org/uniprot/A0A8I5NNU3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9555:PLXNA2 ^@ http://purl.uniprot.org/uniprot/A0A096NAQ6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the plexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:LOC101000797 ^@ http://purl.uniprot.org/uniprot/A0A096NYS9 ^@ Function|||Similarity ^@ Belongs to the TYW1 family.|||Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis. http://togogenome.org/gene/9555:EEF1B2 ^@ http://purl.uniprot.org/uniprot/A0A096MTA1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the EF-1-beta/EF-1-delta family.|||EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.|||EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. http://togogenome.org/gene/9555:SRP72 ^@ http://purl.uniprot.org/uniprot/A0A096MVS7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP72 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).|||Cytoplasm http://togogenome.org/gene/9555:MMGT1 ^@ http://purl.uniprot.org/uniprot/A0A096NGY5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane magnesium transporter (TC 1.A.67) family.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport. http://togogenome.org/gene/9555:RTBDN ^@ http://purl.uniprot.org/uniprot/A0A0A0MVH3|||http://purl.uniprot.org/uniprot/A0A8I5NLL9 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/9555:ANKRD13D ^@ http://purl.uniprot.org/uniprot/A0A096MWK6 ^@ Function|||Subcellular Location Annotation ^@ Endosome|||Late endosome|||Membrane|||Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. http://togogenome.org/gene/9555:PDE5A ^@ http://purl.uniprot.org/uniprot/A0A096NA83|||http://purl.uniprot.org/uniprot/A0A096NYB4 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9555:RNF112 ^@ http://purl.uniprot.org/uniprot/A0A096P347 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9555:INSIG1 ^@ http://purl.uniprot.org/uniprot/A0A096NRW2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INSIG family.|||Endoplasmic reticulum membrane|||Mediates feedback control of cholesterol synthesis.|||Membrane http://togogenome.org/gene/9555:LOC101002193 ^@ http://purl.uniprot.org/uniprot/A0A096ML26 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/9555:OLR81 ^@ http://purl.uniprot.org/uniprot/A9L8W7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:TMEM230 ^@ http://purl.uniprot.org/uniprot/A0A8I5N7P9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM134/TMEM230 family.|||Early endosome|||Endosome|||Involved in trafficking and recycling of synaptic vesicles.|||Late endosome|||Membrane|||Recycling endosome|||autophagosome|||synaptic vesicle|||trans-Golgi network http://togogenome.org/gene/9555:CASTOR1 ^@ http://purl.uniprot.org/uniprot/A0A2I3N4F0 ^@ Similarity ^@ Belongs to the GATS family. http://togogenome.org/gene/9555:TCAF1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MD99 ^@ Similarity ^@ Belongs to the TCAF family. http://togogenome.org/gene/9555:COR52P3 ^@ http://purl.uniprot.org/uniprot/A9L8Z9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:TMEM189 ^@ http://purl.uniprot.org/uniprot/A0A8I5MWB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase CarF family.|||Membrane http://togogenome.org/gene/9555:SLC46A2 ^@ http://purl.uniprot.org/uniprot/A0A096P0U8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:RPL7L1 ^@ http://purl.uniprot.org/uniprot/A0A096NI69 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/9555:ANAPC2 ^@ http://purl.uniprot.org/uniprot/A0A096NWP0 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9555:SLC12A1 ^@ http://purl.uniprot.org/uniprot/A0A2I3N926 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9555:GTF2H4 ^@ http://purl.uniprot.org/uniprot/A0A2I3NCG6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB2 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.|||Nucleus http://togogenome.org/gene/9555:TASOR ^@ http://purl.uniprot.org/uniprot/A0A096NG80 ^@ Similarity ^@ Belongs to the TASOR family. http://togogenome.org/gene/9555:MEGF11 ^@ http://purl.uniprot.org/uniprot/A0A2I3MG03 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:HEPH ^@ http://purl.uniprot.org/uniprot/A0A096MX08 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/9555:SNRPD2 ^@ http://purl.uniprot.org/uniprot/A0A0A0MVC6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.|||cytosol http://togogenome.org/gene/9555:PHF10 ^@ http://purl.uniprot.org/uniprot/A0A096N5R6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAYP family.|||Nucleus http://togogenome.org/gene/9555:RHBDD2 ^@ http://purl.uniprot.org/uniprot/A0A096MVK2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:HMGA1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NQB5|||http://purl.uniprot.org/uniprot/A0A8I5R1Z0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGA family.|||Nucleus http://togogenome.org/gene/9555:MBTPS2 ^@ http://purl.uniprot.org/uniprot/A0A8I5N3J2|||http://purl.uniprot.org/uniprot/A0A8I5NLB1 ^@ Similarity ^@ Belongs to the peptidase M50A family. http://togogenome.org/gene/9555:OVGP1 ^@ http://purl.uniprot.org/uniprot/P36718 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ At the time of ovulation.|||Belongs to the glycosyl hydrolase 18 family.|||Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development.|||Oviduct.|||secretory vesicle http://togogenome.org/gene/9555:CRYBA4 ^@ http://purl.uniprot.org/uniprot/A0A096NRG8 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9555:SYS1 ^@ http://purl.uniprot.org/uniprot/A4K2N5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SYS1 family.|||Golgi apparatus membrane|||Interacts with ARFRP1.|||Involved in protein trafficking. May serve as a receptor for ARFRP1 (By similarity). http://togogenome.org/gene/9555:FBXO32 ^@ http://purl.uniprot.org/uniprot/A0A096MS55 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:ADCY4 ^@ http://purl.uniprot.org/uniprot/A0A096NXB7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/9555:ACAA2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MV66 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/9555:LHX1 ^@ http://purl.uniprot.org/uniprot/A0A096P515 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:SAR1A ^@ http://purl.uniprot.org/uniprot/A0A096P4X2 ^@ Similarity ^@ Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/9555:VPS26B ^@ http://purl.uniprot.org/uniprot/A0A096N4Y0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS26 family.|||Endosome http://togogenome.org/gene/9555:WNT10A ^@ http://purl.uniprot.org/uniprot/A0A096NRV9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9555:AMPD3 ^@ http://purl.uniprot.org/uniprot/A0A2I3N6A9 ^@ Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.|||Homotetramer. http://togogenome.org/gene/9555:SCT ^@ http://purl.uniprot.org/uniprot/A0A096NPU9 ^@ Similarity ^@ Belongs to the glucagon family. http://togogenome.org/gene/9555:TUBB1 ^@ http://purl.uniprot.org/uniprot/A0A096NNF9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9555:NEK6 ^@ http://purl.uniprot.org/uniprot/A0A2I3MHL3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:UTP18 ^@ http://purl.uniprot.org/uniprot/A0A096P4N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat UTP18 family.|||nucleolus http://togogenome.org/gene/9555:FBLN5 ^@ http://purl.uniprot.org/uniprot/A0A096NUF7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:CDC42EP5 ^@ http://purl.uniprot.org/uniprot/A9L922 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/9555:PRC1 ^@ http://purl.uniprot.org/uniprot/A0A096NK58|||http://purl.uniprot.org/uniprot/A0A2I3MUM4 ^@ Similarity ^@ Belongs to the MAP65/ASE1 family. http://togogenome.org/gene/9555:CNP ^@ http://purl.uniprot.org/uniprot/A0A096P5R1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 2H phosphoesterase superfamily. CNPase family.|||Exists as monomers and homodimers.|||May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.|||Melanosome|||Membrane http://togogenome.org/gene/9555:GORASP2 ^@ http://purl.uniprot.org/uniprot/A0A8I5P2F8 ^@ Similarity ^@ Belongs to the GORASP family. http://togogenome.org/gene/9555:SPACA5 ^@ http://purl.uniprot.org/uniprot/A0A096N1G1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9555:CNOT8 ^@ http://purl.uniprot.org/uniprot/A0A096MYG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/9555:UCP1 ^@ http://purl.uniprot.org/uniprot/A0A096MP13 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||May undergo ubiquitin-mediated proteasomal degradation.|||Membrane|||Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:CCNDBP1 ^@ http://purl.uniprot.org/uniprot/A0A096NSP4 ^@ Similarity|||Subunit ^@ Belongs to the CCNDBP1 family.|||Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3. http://togogenome.org/gene/9555:SLC39A8 ^@ http://purl.uniprot.org/uniprot/A0A2I3NIC5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:COX5A ^@ http://purl.uniprot.org/uniprot/B0VYX8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 5A family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Interacts with AFG1L (By similarity). Interacts with RAB5IF (By similarity).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:SMG6 ^@ http://purl.uniprot.org/uniprot/A0A096P2B8 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini.|||Plays a role in nonsense-mediated mRNA decay.|||The PINc domain confers endonuclease activity and is expected to bind the catalytic metal ion.|||cytosol|||nucleolus|||telomere http://togogenome.org/gene/9555:GATAD2B ^@ http://purl.uniprot.org/uniprot/A0A096NDZ1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:DYRK1B ^@ http://purl.uniprot.org/uniprot/A0A0A0MUR9|||http://purl.uniprot.org/uniprot/A0A2I3MV23 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. http://togogenome.org/gene/9555:PPP2R3C ^@ http://purl.uniprot.org/uniprot/A0A096NUL0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:CASC4 ^@ http://purl.uniprot.org/uniprot/A0A096NLY1|||http://purl.uniprot.org/uniprot/A0A2I3M689 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLM family.|||Membrane http://togogenome.org/gene/9555:DCP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MIX2|||http://purl.uniprot.org/uniprot/A0A2I3MXV0 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DCP2 subfamily. http://togogenome.org/gene/9555:C13H9orf116 ^@ http://purl.uniprot.org/uniprot/A0A2I3M723 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.|||cilium axoneme http://togogenome.org/gene/9555:LOC101014053 ^@ http://purl.uniprot.org/uniprot/A0A8I5R1I0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIIc family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:PRPF18 ^@ http://purl.uniprot.org/uniprot/A0A096P3G9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP18 family.|||Nucleus speckle http://togogenome.org/gene/9555:SESN1 ^@ http://purl.uniprot.org/uniprot/A0A096MXD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/9555:TCEA3 ^@ http://purl.uniprot.org/uniprot/A0A096MZV4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family.|||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.|||Nucleus http://togogenome.org/gene/9555:THAP10 ^@ http://purl.uniprot.org/uniprot/A0A8I5NV70 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the THAP1 family.|||DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.|||Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.|||nucleoplasm http://togogenome.org/gene/9555:ARF6 ^@ http://purl.uniprot.org/uniprot/A0A096N6M9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||Cell membrane|||Cleavage furrow|||Endosome membrane|||Midbody ring|||Recycling endosome membrane|||filopodium membrane|||ruffle http://togogenome.org/gene/9555:C5AR2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NHK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:SLC5A1 ^@ http://purl.uniprot.org/uniprot/A9CB39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:CENPU ^@ http://purl.uniprot.org/uniprot/A0A096NXK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-U/AME1 family.|||Nucleus http://togogenome.org/gene/9555:TMCC3 ^@ http://purl.uniprot.org/uniprot/A0A096NQF1 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/9555:LOC101014817 ^@ http://purl.uniprot.org/uniprot/A0A096NG05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF9 family.|||Nucleus http://togogenome.org/gene/9555:STIM1 ^@ http://purl.uniprot.org/uniprot/A0A096N4F6|||http://purl.uniprot.org/uniprot/A0A2I3N7H4|||http://purl.uniprot.org/uniprot/A0A2I3ND97 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:DCP1A ^@ http://purl.uniprot.org/uniprot/A0A096N7E6 ^@ Similarity ^@ Belongs to the DCP1 family. http://togogenome.org/gene/9555:CDIP1 ^@ http://purl.uniprot.org/uniprot/A0A096NLF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/9555:PSMD4 ^@ http://purl.uniprot.org/uniprot/A9X198 ^@ Similarity ^@ Belongs to the proteasome subunit S5A family. http://togogenome.org/gene/9555:MAP7 ^@ http://purl.uniprot.org/uniprot/A0A096NQW1|||http://purl.uniprot.org/uniprot/A0A2I3LNI0|||http://purl.uniprot.org/uniprot/A0A2I3M353|||http://purl.uniprot.org/uniprot/A0A2I3M973 ^@ Similarity ^@ Belongs to the MAP7 family. http://togogenome.org/gene/9555:UGT8 ^@ http://purl.uniprot.org/uniprot/A0A096MR78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9555:AVPI1 ^@ http://purl.uniprot.org/uniprot/A0A096P620 ^@ Function ^@ May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling. http://togogenome.org/gene/9555:ELP2 ^@ http://purl.uniprot.org/uniprot/A0A096MM04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat ELP2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:ACSS3 ^@ http://purl.uniprot.org/uniprot/A0A8I5NDI9 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9555:SRPX ^@ http://purl.uniprot.org/uniprot/A0A096MN41|||http://purl.uniprot.org/uniprot/A0A2I3MLD7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:PAQR3 ^@ http://purl.uniprot.org/uniprot/A0A2I3NDF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9555:EFEMP1 ^@ http://purl.uniprot.org/uniprot/A0A096NP06 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:FADS1 ^@ http://purl.uniprot.org/uniprot/A4UVI1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Specifically, desaturates dihomo-gamma-linoleoate (DGLA) (20:3n-6) and eicosatetraenoate (ETA) (20:4n-3) to generate arachidonate (AA) (20:4n-6) and eicosapentaenoate (EPA) (20:5n-3), respectively (Probable). As a rate limiting enzyme for DGLA (20:3n-6) and AA (20:4n-6)-derived eicosanoid biosynthesis, controls the metabolism of inflammatory lipids like prostaglandin E2, critical for efficient acute inflammatory response and maintenance of epithelium homeostasis. Contributes to membrane phospholipid biosynthesis by providing AA (20:4n-6) as a major acyl chain esterified into phospholipids. In particular, regulates phosphatidylinositol-4,5-bisphosphate levels, modulating inflammatory cytokine production in T-cells (By similarity). Also desaturates (11E)-octadecenoate (trans-vaccenoate)(18:1n-9), a metabolite in the biohydrogenation pathway of LA (18:2n-6) (By similarity).|||Belongs to the fatty acid desaturase type 1 family.|||Does not exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity.|||Endoplasmic reticulum membrane|||Mitochondrion|||The histidine box domains may contain the active site and/or be involved in metal ion binding.|||Widely expressed. Expressed in brain, liver and thymus (at protein level). Isoform 1 seems to be more abundant than isoform 2. Expression of isoform 2 is very low in spleen and not detectable in skeletal muscle. http://togogenome.org/gene/9555:FGF12 ^@ http://purl.uniprot.org/uniprot/A0A096NYR3|||http://purl.uniprot.org/uniprot/A0A2I3MD84 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9555:ARHGEF2 ^@ http://purl.uniprot.org/uniprot/A0A2I3M099 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Golgi apparatus|||Vesicle|||spindle|||tight junction http://togogenome.org/gene/9555:EIF2S1 ^@ http://purl.uniprot.org/uniprot/A0A096NVP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-2-alpha family.|||Stress granule http://togogenome.org/gene/9555:KIF3B ^@ http://purl.uniprot.org/uniprot/A0A096NUY3 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9555:APLP1 ^@ http://purl.uniprot.org/uniprot/A0A0A0MUW3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APP family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:LOC101020627 ^@ http://purl.uniprot.org/uniprot/A0A096NCF6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:LOC101022644 ^@ http://purl.uniprot.org/uniprot/A0A096NQ36 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:LOC101020929 ^@ http://purl.uniprot.org/uniprot/A0A2I3M0D7 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9555:TCEA2 ^@ http://purl.uniprot.org/uniprot/A0A096NN28 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family.|||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.|||Nucleus http://togogenome.org/gene/9555:LOC101010807 ^@ http://purl.uniprot.org/uniprot/A0A8I5N4U0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCO1/2 family.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:TSG101 ^@ http://purl.uniprot.org/uniprot/A0A2I3N4L1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.|||Membrane http://togogenome.org/gene/9555:SYN3 ^@ http://purl.uniprot.org/uniprot/A9CB45 ^@ Similarity ^@ Belongs to the synapsin family. http://togogenome.org/gene/9555:LRRC8D ^@ http://purl.uniprot.org/uniprot/A0A8I5N480 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:AQP8 ^@ http://purl.uniprot.org/uniprot/A0A096NHH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9555:PIGC ^@ http://purl.uniprot.org/uniprot/A0A096N0U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGC family.|||Membrane http://togogenome.org/gene/9555:FAM214B ^@ http://purl.uniprot.org/uniprot/A0A096P189 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATOS family.|||Nucleus http://togogenome.org/gene/9555:TMEM47 ^@ http://purl.uniprot.org/uniprot/A0A8I5N4V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/9555:ARHGAP26 ^@ http://purl.uniprot.org/uniprot/A0A096P012|||http://purl.uniprot.org/uniprot/A0A2I3LJL6 ^@ Subcellular Location Annotation ^@ cytoskeleton|||focal adhesion http://togogenome.org/gene/9555:CAVIN3 ^@ http://purl.uniprot.org/uniprot/A0A096N4Y5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/9555:MFRP ^@ http://purl.uniprot.org/uniprot/A0A096N3G3 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:MMD ^@ http://purl.uniprot.org/uniprot/A0A2I3N1M7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9555:ACTA1 ^@ http://purl.uniprot.org/uniprot/A0A096N2Y2 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9555:SEC61A2 ^@ http://purl.uniprot.org/uniprot/A0A096P3F1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:SH3BGRL2 ^@ http://purl.uniprot.org/uniprot/A0A096NPI1 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/9555:CCL26 ^@ http://purl.uniprot.org/uniprot/A0A096NF44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9555:IDE ^@ http://purl.uniprot.org/uniprot/A0A096P5K6|||http://purl.uniprot.org/uniprot/A0A096P5L0|||http://purl.uniprot.org/uniprot/A0A8I5NYE6 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/9555:ATP6V1C1 ^@ http://purl.uniprot.org/uniprot/A0A096N107 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits. http://togogenome.org/gene/9555:SYNDIG1 ^@ http://purl.uniprot.org/uniprot/A0A8I5R9I9 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9555:LOC101014662 ^@ http://purl.uniprot.org/uniprot/A0A2I3MH43 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL33 family. http://togogenome.org/gene/9555:SMAD1 ^@ http://purl.uniprot.org/uniprot/A0A096NQS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:IGFBP4 ^@ http://purl.uniprot.org/uniprot/A0A096P5H2 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Binds IGF2 more than IGF1.|||IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9555:GRWD1 ^@ http://purl.uniprot.org/uniprot/A0A0A0MW66 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:UBE2D1 ^@ http://purl.uniprot.org/uniprot/A0A096P578 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9555:POPDC2 ^@ http://purl.uniprot.org/uniprot/A0A096MS37|||http://purl.uniprot.org/uniprot/A0A2I3NDT3 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/9555:SF3B1 ^@ http://purl.uniprot.org/uniprot/A0A096N1H4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3B1 family.|||Nucleus http://togogenome.org/gene/9555:RNASET2 ^@ http://purl.uniprot.org/uniprot/A0A096N0H3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase T2 family.|||Lysosome lumen http://togogenome.org/gene/9555:RND3 ^@ http://purl.uniprot.org/uniprot/A0A096NSN7 ^@ Function ^@ Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. http://togogenome.org/gene/9555:DEFB123 ^@ http://purl.uniprot.org/uniprot/A0A096NV13 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9555:CREM ^@ http://purl.uniprot.org/uniprot/A0A2I3MP66|||http://purl.uniprot.org/uniprot/A0A2I3MRA9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:DMC1 ^@ http://purl.uniprot.org/uniprot/A0A2I3N304 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. DMC1 subfamily.|||May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.|||Nucleus http://togogenome.org/gene/9555:INTS10 ^@ http://purl.uniprot.org/uniprot/A0A096MXL7|||http://purl.uniprot.org/uniprot/A0A2I3MF91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 10 family.|||Nucleus http://togogenome.org/gene/9555:VRK1 ^@ http://purl.uniprot.org/uniprot/A0A096NJP0|||http://purl.uniprot.org/uniprot/A0A8I5NNJ9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:COX8A ^@ http://purl.uniprot.org/uniprot/Q863G9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIII family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:CCL8 ^@ http://purl.uniprot.org/uniprot/A0A8I5NTU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9555:TSPAN15 ^@ http://purl.uniprot.org/uniprot/A0A096P4Z1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:MYOD1 ^@ http://purl.uniprot.org/uniprot/A0A096MNT6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.|||Nucleus http://togogenome.org/gene/9555:SLC35F6 ^@ http://purl.uniprot.org/uniprot/A0A2I3LT70 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SLC35F solute transporter family.|||Interacts with SLC25A5.|||May play a role as a nucleotide-sugar transporter.|||Membrane|||Mitochondrion http://togogenome.org/gene/9555:NKAIN4 ^@ http://purl.uniprot.org/uniprot/A0A096NN74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NKAIN family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:MSMB ^@ http://purl.uniprot.org/uniprot/Q28767 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta-microseminoprotein family.|||Homodimer; Interacts with PI16.|||Secreted http://togogenome.org/gene/9555:GABRQ ^@ http://purl.uniprot.org/uniprot/A0A096NQE6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9555:DPCD ^@ http://purl.uniprot.org/uniprot/A0A096P6C0 ^@ Similarity ^@ Belongs to the DPCD family. http://togogenome.org/gene/9555:CD164 ^@ http://purl.uniprot.org/uniprot/A0A2I3M9N4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD164 family.|||Membrane http://togogenome.org/gene/9555:RXRB ^@ http://purl.uniprot.org/uniprot/A0A2I3LM93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Nucleus http://togogenome.org/gene/9555:DPM3 ^@ http://purl.uniprot.org/uniprot/A0A8I5NE21 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPM3 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER. http://togogenome.org/gene/9555:PPP1R9A ^@ http://purl.uniprot.org/uniprot/A0A096MNQ8|||http://purl.uniprot.org/uniprot/A0A2I3M2B9|||http://purl.uniprot.org/uniprot/A0A2I3N216|||http://purl.uniprot.org/uniprot/A0A2I3NCN6 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9555:SYF2 ^@ http://purl.uniprot.org/uniprot/A0A096NS30 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SYF2 family.|||Involved in pre-mRNA splicing.|||May be part of a spliceosome complex.|||Nucleus http://togogenome.org/gene/9555:SOX14 ^@ http://purl.uniprot.org/uniprot/A0A096MSU2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:AKT1 ^@ http://purl.uniprot.org/uniprot/A0A2I3N0A6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. http://togogenome.org/gene/9555:LEPROTL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3N4W5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OB-RGRP/VPS55 family.|||Membrane http://togogenome.org/gene/9555:ANXA11 ^@ http://purl.uniprot.org/uniprot/A0A8I5P103 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9555:DNPEP ^@ http://purl.uniprot.org/uniprot/B0CM48 ^@ Similarity|||Subunit ^@ Belongs to the peptidase M18 family.|||Tetrahedron-shaped homododecamer built from six homodimers. http://togogenome.org/gene/9555:SAMHD1 ^@ http://purl.uniprot.org/uniprot/H6WEA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAMHD1 family.|||Chromosome http://togogenome.org/gene/9555:NDUFB3 ^@ http://purl.uniprot.org/uniprot/A0A2I3LXH2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB3 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:C1H1orf52 ^@ http://purl.uniprot.org/uniprot/A0A096NYW3 ^@ Similarity ^@ Belongs to the UPF0690 family. http://togogenome.org/gene/9555:SLC30A7 ^@ http://purl.uniprot.org/uniprot/A0A8I5NYV2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Functions as a zinc transporter.|||Homooligomer.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9555:CGAS ^@ http://purl.uniprot.org/uniprot/A9X187 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9555:BDKRB2 ^@ http://purl.uniprot.org/uniprot/A0A096NJL8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.|||Membrane|||Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9555:RHBDD1 ^@ http://purl.uniprot.org/uniprot/A0A096MQY3|||http://purl.uniprot.org/uniprot/A0A8I5N082|||http://purl.uniprot.org/uniprot/A0A8I5NE71 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:MID1 ^@ http://purl.uniprot.org/uniprot/A0A2I3M7X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Nucleus|||cytoskeleton http://togogenome.org/gene/9555:LOC101001697 ^@ http://purl.uniprot.org/uniprot/A0A096NPM2 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9555:NGFR ^@ http://purl.uniprot.org/uniprot/A0A2I3MWN6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:REEP5 ^@ http://purl.uniprot.org/uniprot/A0A096N5D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/9555:NFIC ^@ http://purl.uniprot.org/uniprot/A0A0A0MWM6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTF/NF-I family.|||Binds DNA as a homodimer.|||Nucleus|||Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. http://togogenome.org/gene/9555:SNRPG ^@ http://purl.uniprot.org/uniprot/A0A2I3LWP6|||http://purl.uniprot.org/uniprot/A0A2I3M0D3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus|||Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.|||cytosol http://togogenome.org/gene/9555:HBEGF ^@ http://purl.uniprot.org/uniprot/A0A096N0E6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:MTMR10 ^@ http://purl.uniprot.org/uniprot/A0A2I3N4U6 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9555:GRK7 ^@ http://purl.uniprot.org/uniprot/A0A096N8R4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9555:PPTC7 ^@ http://purl.uniprot.org/uniprot/A0A096N2X7 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9555:LOC101016081 ^@ http://purl.uniprot.org/uniprot/A0A096P6A9 ^@ Similarity|||Subunit ^@ Belongs to the GST superfamily. Theta family.|||Homodimer. http://togogenome.org/gene/9555:TMEM54 ^@ http://purl.uniprot.org/uniprot/A0A096MVM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM54 family.|||Membrane http://togogenome.org/gene/9555:LGR5 ^@ http://purl.uniprot.org/uniprot/A0A096MVL6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:GMPPB ^@ http://purl.uniprot.org/uniprot/A0A096NQL7|||http://purl.uniprot.org/uniprot/A0A2I3LN07 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/9555:CCL11 ^@ http://purl.uniprot.org/uniprot/A0A096P3T9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9555:CHRNG ^@ http://purl.uniprot.org/uniprot/A0A096MXP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9555:ACER3 ^@ http://purl.uniprot.org/uniprot/A0A096NB86|||http://purl.uniprot.org/uniprot/A0A8I5NK04 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:PIK3IP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MM51|||http://purl.uniprot.org/uniprot/A0A2I3MU72 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:BNIP1 ^@ http://purl.uniprot.org/uniprot/A0A096MRU8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:ZDHHC21 ^@ http://purl.uniprot.org/uniprot/A0A8I5NRC6 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9555:ZNF326 ^@ http://purl.uniprot.org/uniprot/A0A096MKT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AKAP95 family.|||Nucleus matrix http://togogenome.org/gene/9555:ARHGEF3 ^@ http://purl.uniprot.org/uniprot/A0A096NCB8|||http://purl.uniprot.org/uniprot/A0A2I3LPD2|||http://purl.uniprot.org/uniprot/A0A2I3M1B7|||http://purl.uniprot.org/uniprot/A0A2I3M6H0 ^@ Function|||Subcellular Location Annotation ^@ Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.|||Cytoplasm http://togogenome.org/gene/9555:TES ^@ http://purl.uniprot.org/uniprot/A0M8R4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prickle / espinas / testin family.|||Cytoplasm|||Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN (By similarity). Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer (By similarity).|||Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor (By similarity).|||The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering interactions with ZYX.|||focal adhesion http://togogenome.org/gene/9555:OXER1 ^@ http://purl.uniprot.org/uniprot/A0A096MNR1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9555:TNS2 ^@ http://purl.uniprot.org/uniprot/A0A096N5N6|||http://purl.uniprot.org/uniprot/A0A096NAD9|||http://purl.uniprot.org/uniprot/A0A2I3M7P7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTEN phosphatase protein family.|||focal adhesion http://togogenome.org/gene/9555:ORC6 ^@ http://purl.uniprot.org/uniprot/A0A096NI17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC6 family.|||Nucleus http://togogenome.org/gene/9555:PTGES2 ^@ http://purl.uniprot.org/uniprot/A0A096P1Y6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GST superfamily.|||Membrane http://togogenome.org/gene/9555:LARS1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NSP2 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9555:GPR33 ^@ http://purl.uniprot.org/uniprot/A0A8I5R2M3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:HOGA1 ^@ http://purl.uniprot.org/uniprot/A0A096P614 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the final step in the metabolic pathway of hydroxyproline.|||Homotetramer. http://togogenome.org/gene/9555:ELOVL6 ^@ http://purl.uniprot.org/uniprot/A0A096MRK4 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL6 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||N-Glycosylated. http://togogenome.org/gene/9555:GRPEL1 ^@ http://purl.uniprot.org/uniprot/A0A8I5R942 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GrpE family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion matrix http://togogenome.org/gene/9555:RELN ^@ http://purl.uniprot.org/uniprot/A0A096NGR4|||http://purl.uniprot.org/uniprot/A0A2I3LGE4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the reelin family.|||Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Oligomer of disulfide-linked homodimers. Binds to the ectodomains of VLDLR and LRP8/APOER2.|||extracellular matrix http://togogenome.org/gene/9555:SLC4A7 ^@ http://purl.uniprot.org/uniprot/A0A2I3MYK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:PIK3CB ^@ http://purl.uniprot.org/uniprot/A0A096NG14 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9555:AMACR ^@ http://purl.uniprot.org/uniprot/A7XAJ9 ^@ Similarity ^@ Belongs to the CoA-transferase III family. http://togogenome.org/gene/9555:AGAP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3M2D4 ^@ Similarity ^@ Belongs to the centaurin gamma-like family. http://togogenome.org/gene/9555:EDEM1 ^@ http://purl.uniprot.org/uniprot/A0A096N098 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9555:NUP93 ^@ http://purl.uniprot.org/uniprot/A0A2I3MAC7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin interacting component (NIC) family.|||Nucleus membrane|||Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.|||nuclear pore complex http://togogenome.org/gene/9555:DUSP13 ^@ http://purl.uniprot.org/uniprot/A0A096P4J7 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9555:CLDN20 ^@ http://purl.uniprot.org/uniprot/A0A8I5NU16 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9555:TMEM121B ^@ http://purl.uniprot.org/uniprot/A0A096NVX4 ^@ Similarity ^@ Belongs to the TMEM121 family. http://togogenome.org/gene/9555:GUK1 ^@ http://purl.uniprot.org/uniprot/A0A2I3N7Y9 ^@ Similarity ^@ Belongs to the guanylate kinase family. http://togogenome.org/gene/9555:USP44 ^@ http://purl.uniprot.org/uniprot/A0A096MNN2 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9555:TMCC2 ^@ http://purl.uniprot.org/uniprot/A0A096N2U0|||http://purl.uniprot.org/uniprot/A0A2I3LE58 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/9555:CDKN1B ^@ http://purl.uniprot.org/uniprot/A0A2I3N9L6 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/9555:LOC101015090 ^@ http://purl.uniprot.org/uniprot/A0A2I3MGF0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COA3 family.|||Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.|||Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.|||Membrane|||Required for assembly of cytochrome c oxidase (complex IV). http://togogenome.org/gene/9555:GDF9 ^@ http://purl.uniprot.org/uniprot/A9CB18 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked (By similarity).|||Ovarian physiology and fertility are controlled by endocrine and paracrine signals. These act in a species-dependent manner and determine the ovulation quota in different mammalian species. While humans, and mammals such as the cow or red deer, normally ovulate only one egg per cycle, other mammals such as mouse and pig can ovulate in excess of ten per cycle. The mechanisms that regulate the species-specific differences in the number of follicles that go onto ovulate during each reproductive cycle are poorly understood. According to PubMed:21970812, mRNA expression levels of GDF9 and BMP15 are tightly coregulated within each species and influence species-specific ovulation-rates.|||Phosphorylated; phosphorylation is critical for GDF9 function.|||Required for ovarian folliculogenesis.|||Secreted http://togogenome.org/gene/9555:LOC101013677 ^@ http://purl.uniprot.org/uniprot/A0A096MPD3 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:TMEM233 ^@ http://purl.uniprot.org/uniprot/A0A096NFS2 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9555:ATG5 ^@ http://purl.uniprot.org/uniprot/A0A096NR43|||http://purl.uniprot.org/uniprot/A0A2I3MC73 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG5 family.|||Conjugated with ATG12.|||Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.|||May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.|||Preautophagosomal structure membrane http://togogenome.org/gene/9555:VAMP4 ^@ http://purl.uniprot.org/uniprot/A0A096N8H6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9555:MOSPD1 ^@ http://purl.uniprot.org/uniprot/A0A2I3NC89 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:CDC26 ^@ http://purl.uniprot.org/uniprot/A0A8I5NKK5 ^@ Function|||Similarity ^@ Belongs to the CDC26 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. http://togogenome.org/gene/9555:DYNLT3 ^@ http://purl.uniprot.org/uniprot/A0A8I5N8I5 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/9555:MB21D2 ^@ http://purl.uniprot.org/uniprot/A0A096MS86 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9555:TSPO2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LM00|||http://purl.uniprot.org/uniprot/A0A8I5NJR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TspO/BZRP family.|||Membrane http://togogenome.org/gene/9555:SMPD2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NJJ9 ^@ Similarity ^@ Belongs to the neutral sphingomyelinase family. http://togogenome.org/gene/9555:OPN1LW ^@ http://purl.uniprot.org/uniprot/A9CB54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/9555:MAGI3 ^@ http://purl.uniprot.org/uniprot/A0A096N7W8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:OR51B5 ^@ http://purl.uniprot.org/uniprot/A9L8Y2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:IRF2BP1 ^@ http://purl.uniprot.org/uniprot/A0A0A0MX84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF2BP family.|||Nucleus http://togogenome.org/gene/9555:MPL ^@ http://purl.uniprot.org/uniprot/A0A096MUA6 ^@ Similarity ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily. http://togogenome.org/gene/9555:ING2 ^@ http://purl.uniprot.org/uniprot/A0A096MQ17 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9555:TMEM225 ^@ http://purl.uniprot.org/uniprot/A0A096ML58 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:NOX4 ^@ http://purl.uniprot.org/uniprot/A0A096MLX2|||http://purl.uniprot.org/uniprot/A0A8I5N9S5|||http://purl.uniprot.org/uniprot/A0A8I5NCP7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:HLF ^@ http://purl.uniprot.org/uniprot/A0A096P4P5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/9555:MTF2 ^@ http://purl.uniprot.org/uniprot/A0A096NPN7|||http://purl.uniprot.org/uniprot/A0A2I3M2W9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Polycomblike family.|||Nucleus http://togogenome.org/gene/9555:RUNX2 ^@ http://purl.uniprot.org/uniprot/A0A096NIQ2|||http://purl.uniprot.org/uniprot/A0A096NIQ3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:CASS4 ^@ http://purl.uniprot.org/uniprot/A0A096NNJ9|||http://purl.uniprot.org/uniprot/A0A096NNK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAS family.|||focal adhesion http://togogenome.org/gene/9555:ENTPD2 ^@ http://purl.uniprot.org/uniprot/A0A096NWP8 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9555:CAST ^@ http://purl.uniprot.org/uniprot/A0A2I3LCQ6|||http://purl.uniprot.org/uniprot/A0A2I3N315|||http://purl.uniprot.org/uniprot/A0A2I3NBZ6 ^@ Function|||Similarity ^@ Belongs to the protease inhibitor I27 (calpastatin) family.|||Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. http://togogenome.org/gene/9555:LOC101009919 ^@ http://purl.uniprot.org/uniprot/A0A096MWB2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:TBC1D7 ^@ http://purl.uniprot.org/uniprot/A0A096NL01 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Vesicle http://togogenome.org/gene/9555:LOC101016656 ^@ http://purl.uniprot.org/uniprot/A0A096MY25 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9555:AMPD2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LVJ0|||http://purl.uniprot.org/uniprot/A0A2I3MGR0 ^@ Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.|||Homotetramer. http://togogenome.org/gene/9555:KIZ ^@ http://purl.uniprot.org/uniprot/A0A2I3MBY2|||http://purl.uniprot.org/uniprot/A0A2I3MIM3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the kizuna family.|||Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.|||centrosome|||cilium basal body http://togogenome.org/gene/9555:SMIM5 ^@ http://purl.uniprot.org/uniprot/A0A096NSX3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:TNC ^@ http://purl.uniprot.org/uniprot/A0A096P0R9|||http://purl.uniprot.org/uniprot/A0A2I3MI00|||http://purl.uniprot.org/uniprot/A0A2I3NHL6|||http://purl.uniprot.org/uniprot/A0A8I5P2M7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tenascin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9555:COQ3 ^@ http://purl.uniprot.org/uniprot/A0A096NRN1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Mitochondrion inner membrane|||O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. http://togogenome.org/gene/9555:SMOC1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MFA5|||http://purl.uniprot.org/uniprot/A0A2I3MTE7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:EIF1B ^@ http://purl.uniprot.org/uniprot/A0A2I3MK00 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/9555:FAM92A ^@ http://purl.uniprot.org/uniprot/A0A2I3MP22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CIBAR family.|||centriole|||cilium basal body http://togogenome.org/gene/9555:SLC25A45 ^@ http://purl.uniprot.org/uniprot/A0A096N653 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9555:P2RY13 ^@ http://purl.uniprot.org/uniprot/A0A096MY47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:CELF2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MN26|||http://purl.uniprot.org/uniprot/A0A2I3NI13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CELF/BRUNOL family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:LOC101000558 ^@ http://purl.uniprot.org/uniprot/A0A2I3LHG9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/9555:KCNS1 ^@ http://purl.uniprot.org/uniprot/A4K2M4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.1/KCNS1 sub-subfamily.|||Cell membrane|||Heteromultimer with KCNB1 and KCNB2. Does not form homomultimers.|||Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2.|||The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region. http://togogenome.org/gene/9555:STAT5B ^@ http://purl.uniprot.org/uniprot/A0A2I3N366 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:TM7SF2 ^@ http://purl.uniprot.org/uniprot/A0A096MLS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Membrane http://togogenome.org/gene/9555:TLR5 ^@ http://purl.uniprot.org/uniprot/B9VGK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9555:LOC101012887 ^@ http://purl.uniprot.org/uniprot/A0A096N1G9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 18 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9555:GCNT2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LEE4 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9555:ABLIM1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MXX1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:STEAP1 ^@ http://purl.uniprot.org/uniprot/B0CM24 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:CAV2 ^@ http://purl.uniprot.org/uniprot/A0M8R5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the caveolin family.|||Cell membrane|||Cytoplasm|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).|||Monomer or homodimer (By similarity). Interacts with CAV1; the interaction forms a stable heterooligomeric complex that is required for targeting to lipid rafts and for caveolae formation. Tyrosine phosphorylated forms do not form heterooligomers with the Tyr-19-phosphorylated form existing as a monomer or dimer, and the Tyr-27-form as a monomer only. Interacts (tyrosine phosphorylated form) with the SH2 domain-containing proteins, RASA1, NCK1 and SRC. Interacts (tyrosine phosphorylated form) with INSR, the interaction (Tyr-27-phosphorylated form) is increased on insulin stimulation. Interacts (Tyr-19 phosphorylated form) with MAPK1 (phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with STAT3; the interaction is increased on insulin-induced tyrosine phosphorylation leading to STAT activation (By similarity).|||Nucleus|||Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells (By similarity). Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced 'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin (By. similarity).|||caveola http://togogenome.org/gene/9555:LOC100997522 ^@ http://purl.uniprot.org/uniprot/A0A8I5NQP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9555:MEF2C ^@ http://purl.uniprot.org/uniprot/A0A2I3M740|||http://purl.uniprot.org/uniprot/A0A2I3NEM1|||http://purl.uniprot.org/uniprot/A0A2I3NIK4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:NDUFV3 ^@ http://purl.uniprot.org/uniprot/A0A096NIR7|||http://purl.uniprot.org/uniprot/A0A2I3NC21 ^@ Function|||Similarity|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.|||Belongs to the complex I NDUFV3 subunit family.|||Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme. http://togogenome.org/gene/9555:GHRHR ^@ http://purl.uniprot.org/uniprot/A0A2I3LMD1|||http://purl.uniprot.org/uniprot/A0A2I3M207 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:ARMC8 ^@ http://purl.uniprot.org/uniprot/A0A2I3LRM4|||http://purl.uniprot.org/uniprot/A0A2I3M3G8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9555:PPM1F ^@ http://purl.uniprot.org/uniprot/A0A096NSA4 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9555:FAM171B ^@ http://purl.uniprot.org/uniprot/A0A096N7Z9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM171 family.|||Membrane http://togogenome.org/gene/9555:LOC101021233 ^@ http://purl.uniprot.org/uniprot/A0A096NA67 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/9555:TVP23B ^@ http://purl.uniprot.org/uniprot/A0A8I5NLX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP23 family.|||Membrane http://togogenome.org/gene/9555:ZC3HC1 ^@ http://purl.uniprot.org/uniprot/A0A2I3M4C0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:KATNB1 ^@ http://purl.uniprot.org/uniprot/A0A096NIW4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat KATNB1 family.|||Cytoplasm|||Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome. This interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein, microtubules, NDEL1 and PAFAH1B1. Interacts with KATNAL1; this interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.|||Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.|||centrosome|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/9555:PNOC ^@ http://purl.uniprot.org/uniprot/A0A096MXC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the opioid neuropeptide precursor family.|||Secreted http://togogenome.org/gene/9555:GPRC5D ^@ http://purl.uniprot.org/uniprot/A0A2I3LMX9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9555:NCAPG ^@ http://purl.uniprot.org/uniprot/A0A096NZI5|||http://purl.uniprot.org/uniprot/A0A8I5NMW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CND3 (condensin subunit 3) family.|||Chromosome http://togogenome.org/gene/9555:SLC6A13 ^@ http://purl.uniprot.org/uniprot/A0A096N1Q5 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily.|||Cell membrane|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9555:SENP8 ^@ http://purl.uniprot.org/uniprot/A0A096MNS5 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/9555:LOC101004941 ^@ http://purl.uniprot.org/uniprot/A0A096NF07 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:DDX3X ^@ http://purl.uniprot.org/uniprot/A0A8I5NZW9 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9555:PUSL1 ^@ http://purl.uniprot.org/uniprot/A0A096N5L6 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/9555:GPR180 ^@ http://purl.uniprot.org/uniprot/A0A096ML82 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:ZNF598 ^@ http://purl.uniprot.org/uniprot/A0A096NKZ7 ^@ Similarity ^@ Belongs to the ZNF598/HEL2 family. http://togogenome.org/gene/9555:MOCS3 ^@ http://purl.uniprot.org/uniprot/A0A096N6H8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds 1 zinc ion per subunit.|||Cytoplasm|||In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.|||Interacts with NFS1.|||Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions. http://togogenome.org/gene/9555:SLITRK3 ^@ http://purl.uniprot.org/uniprot/A0A096MMG8 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9555:PRKAA1 ^@ http://purl.uniprot.org/uniprot/A0A096N9P0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. http://togogenome.org/gene/9555:ATP5PO ^@ http://purl.uniprot.org/uniprot/A9CB05 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase delta chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:SPDYA ^@ http://purl.uniprot.org/uniprot/A0A096P0B0 ^@ Similarity ^@ Belongs to the Speedy/Ringo family. http://togogenome.org/gene/9555:POLR2F ^@ http://purl.uniprot.org/uniprot/A0A2I3LN40 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.|||Nucleus http://togogenome.org/gene/9555:HAL ^@ http://purl.uniprot.org/uniprot/A0A096NCJ1 ^@ Similarity ^@ Belongs to the PAL/histidase family. http://togogenome.org/gene/9555:TSR2 ^@ http://purl.uniprot.org/uniprot/A0A096MN80 ^@ Function|||Similarity ^@ Belongs to the TSR2 family.|||May be involved in 20S pre-rRNA processing. http://togogenome.org/gene/9555:TBL1X ^@ http://purl.uniprot.org/uniprot/A0A096MZ67 ^@ Similarity ^@ Belongs to the WD repeat EBI family. http://togogenome.org/gene/9555:PRMT5 ^@ http://purl.uniprot.org/uniprot/A0A096N5H2|||http://purl.uniprot.org/uniprot/A0A2I3LK67 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).|||Belongs to the class I-like SAM-binding methyltransferase superfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:WTAP ^@ http://purl.uniprot.org/uniprot/A0A2I3LKI4|||http://purl.uniprot.org/uniprot/A0A8I5NKC2 ^@ Similarity ^@ Belongs to the fl(2)d family. http://togogenome.org/gene/9555:RBM22 ^@ http://purl.uniprot.org/uniprot/A0A096N735 ^@ Similarity ^@ Belongs to the SLT11 family. http://togogenome.org/gene/9555:MRPS6 ^@ http://purl.uniprot.org/uniprot/A0A8I5NH44 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family. http://togogenome.org/gene/9555:TDRD7 ^@ http://purl.uniprot.org/uniprot/A0A8I5R8E5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TDRD7 family.|||Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.|||Cytoplasm|||Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex containing CABLES1, CDK16 and CDK17. Interacts with CABLES1, CDK17 and PIWIL1. http://togogenome.org/gene/9555:CHN1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LM77 ^@ Function ^@ GTPase-activating protein for p21-rac. http://togogenome.org/gene/9555:LOC101018740 ^@ http://purl.uniprot.org/uniprot/A0A096NQ62 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9555:LOC101004754 ^@ http://purl.uniprot.org/uniprot/A0A2I3LXH2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB3 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:LOC101024192 ^@ http://purl.uniprot.org/uniprot/A0A096NJ15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9555:VPS11 ^@ http://purl.uniprot.org/uniprot/A0A096NAD1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS11 family.|||Cytoplasmic vesicle|||Early endosome|||Late endosome membrane|||Lysosome membrane|||Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.|||autophagosome|||clathrin-coated vesicle http://togogenome.org/gene/9555:PTH1R ^@ http://purl.uniprot.org/uniprot/A0A096MU19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:SERPINB11 ^@ http://purl.uniprot.org/uniprot/A9RA93 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9555:ID2 ^@ http://purl.uniprot.org/uniprot/A0A8I5MW66 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:SYN1 ^@ http://purl.uniprot.org/uniprot/A0A096NAC9 ^@ Similarity ^@ Belongs to the synapsin family. http://togogenome.org/gene/9555:LOC116268603 ^@ http://purl.uniprot.org/uniprot/A0A096NG83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ropporin family.|||flagellum http://togogenome.org/gene/9555:NPPA ^@ http://purl.uniprot.org/uniprot/A0A096NCR4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the natriuretic peptide family.|||Cell projection|||Homodimer; disulfide-linked antiparallel dimer.|||May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips.|||May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips.|||May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.|||May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips.|||Secreted http://togogenome.org/gene/9555:GDF11 ^@ http://purl.uniprot.org/uniprot/A0A096MW05 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9555:HAT1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MSH3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HAT1 family.|||Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.|||Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac). http://togogenome.org/gene/9555:AZGP1 ^@ http://purl.uniprot.org/uniprot/A0A096N8U6 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9555:ST3GAL5 ^@ http://purl.uniprot.org/uniprot/A0A096NZW4|||http://purl.uniprot.org/uniprot/A0A2I3NDP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9555:PPP1R12A ^@ http://purl.uniprot.org/uniprot/A0A8I5N5D1|||http://purl.uniprot.org/uniprot/A0A8I5N830 ^@ Subcellular Location Annotation|||Subunit ^@ PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.|||stress fiber http://togogenome.org/gene/9555:MRPS18A ^@ http://purl.uniprot.org/uniprot/A0A096NII4 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9555:HABP2 ^@ http://purl.uniprot.org/uniprot/A0A096N5I4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:WNT1 ^@ http://purl.uniprot.org/uniprot/A0A096NZ21 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9555:NPAS4 ^@ http://purl.uniprot.org/uniprot/A0A2I3MYJ5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:PAIP2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NKP7 ^@ Similarity ^@ Belongs to the PAIP2 family. http://togogenome.org/gene/9555:SLC22A7 ^@ http://purl.uniprot.org/uniprot/A0A096NIC4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:ZDHHC23 ^@ http://purl.uniprot.org/uniprot/A0A096NQM2 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9555:OR51F1 ^@ http://purl.uniprot.org/uniprot/A9L900 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:FYN ^@ http://purl.uniprot.org/uniprot/A0A096NW74|||http://purl.uniprot.org/uniprot/A0A2I3MR50 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9555:NEDD9 ^@ http://purl.uniprot.org/uniprot/A0A096NKX9|||http://purl.uniprot.org/uniprot/A0A2I3MEQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAS family.|||focal adhesion http://togogenome.org/gene/9555:SERPINB8 ^@ http://purl.uniprot.org/uniprot/A9RA97 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9555:KCNG3 ^@ http://purl.uniprot.org/uniprot/A0A096MZR0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9555:FZD6 ^@ http://purl.uniprot.org/uniprot/A0A096P0Y9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:RETN ^@ http://purl.uniprot.org/uniprot/A0A0A0MU90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the resistin/FIZZ family.|||Secreted http://togogenome.org/gene/9555:PPP2R5D ^@ http://purl.uniprot.org/uniprot/A0A2I3NBH7 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9555:CHRD ^@ http://purl.uniprot.org/uniprot/A0A2I3LJ53 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chordin family.|||Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.|||Secreted http://togogenome.org/gene/9555:TP63 ^@ http://purl.uniprot.org/uniprot/A0A096MTM8|||http://purl.uniprot.org/uniprot/A0A2I3MEJ7|||http://purl.uniprot.org/uniprot/A0A2I3MKF2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.|||Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.|||Belongs to the p53 family.|||Binds 1 zinc ion per subunit.|||Binds DNA as a homotetramer.|||Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:INKA1 ^@ http://purl.uniprot.org/uniprot/A0A096NQM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INKA family.|||Nucleus http://togogenome.org/gene/9555:SCRN2 ^@ http://purl.uniprot.org/uniprot/A0A096P404 ^@ Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily. http://togogenome.org/gene/9555:GNPAT ^@ http://purl.uniprot.org/uniprot/A0A096MTB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GPAT/DAPAT family.|||Peroxisome membrane http://togogenome.org/gene/9555:NOP16 ^@ http://purl.uniprot.org/uniprot/A0A2I3N4L9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP16 family.|||nucleolus http://togogenome.org/gene/9555:LOC101011847 ^@ http://purl.uniprot.org/uniprot/A0A096N0E3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMDT1/EMRE family.|||Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.|||Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:WASF3 ^@ http://purl.uniprot.org/uniprot/A0A096N954 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCAR/WAVE family.|||Binds actin and the Arp2/3 complex.|||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|||cytoskeleton http://togogenome.org/gene/9555:KRT76 ^@ http://purl.uniprot.org/uniprot/A0A096N7Q2 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9555:SLC25A22 ^@ http://purl.uniprot.org/uniprot/A0A096MQF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9555:DKK2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NHA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/9555:ADSS1 ^@ http://purl.uniprot.org/uniprot/A0A096NK30 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.|||Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. http://togogenome.org/gene/9555:MPC2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MBB8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:RPL19 ^@ http://purl.uniprot.org/uniprot/A0A096P5A3 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/9555:CD40LG ^@ http://purl.uniprot.org/uniprot/A0A8I5NJQ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.|||Belongs to the tumor necrosis factor family.|||Cell surface|||Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.|||Homotrimer. http://togogenome.org/gene/9555:SS18L2 ^@ http://purl.uniprot.org/uniprot/A0A096MU15 ^@ Similarity ^@ Belongs to the SS18 family. http://togogenome.org/gene/9555:CCNY ^@ http://purl.uniprot.org/uniprot/A0A096P466|||http://purl.uniprot.org/uniprot/A0A8I5NQX6 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin Y subfamily. http://togogenome.org/gene/9555:NHP2 ^@ http://purl.uniprot.org/uniprot/A0A096MLP0|||http://purl.uniprot.org/uniprot/A0A2I3LKX0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/9555:FAM53B ^@ http://purl.uniprot.org/uniprot/A0A096NU59|||http://purl.uniprot.org/uniprot/A0A8I5N187 ^@ Similarity ^@ Belongs to the FAM53 family. http://togogenome.org/gene/9555:DIABLO ^@ http://purl.uniprot.org/uniprot/A0A096N562 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9555:NR1H4 ^@ http://purl.uniprot.org/uniprot/A0A096NC34|||http://purl.uniprot.org/uniprot/A0A2I3MZZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9555:TMEM255A ^@ http://purl.uniprot.org/uniprot/A0A096MXR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM255 family.|||Membrane http://togogenome.org/gene/9555:ATP6 ^@ http://purl.uniprot.org/uniprot/K9MVJ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase A chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:OXR1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MFX2|||http://purl.uniprot.org/uniprot/A0A2I3MHJ2|||http://purl.uniprot.org/uniprot/A0A2I3MPL4|||http://purl.uniprot.org/uniprot/A0A2I3N8P9 ^@ Similarity ^@ Belongs to the OXR1 family. http://togogenome.org/gene/9555:WDR91 ^@ http://purl.uniprot.org/uniprot/A0A2I3M9I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR91 family.|||Early endosome membrane|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9555:ESD ^@ http://purl.uniprot.org/uniprot/A0A096MM92|||http://purl.uniprot.org/uniprot/A0A8I5NZP0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the esterase D family.|||Cytoplasmic vesicle|||Serine hydrolase involved in the detoxification of formaldehyde. http://togogenome.org/gene/9555:MEN1 ^@ http://purl.uniprot.org/uniprot/B0CM67 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:ABCD3 ^@ http://purl.uniprot.org/uniprot/A0A8I5NEJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9555:ZSCAN16 ^@ http://purl.uniprot.org/uniprot/A0A096NLJ5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:OCIAD1 ^@ http://purl.uniprot.org/uniprot/A0A096NQ24 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OCIAD1 family.|||Endosome|||Interacts with STAT3.|||Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.|||The OCIA domain is necessary and sufficient for endosomal localization. http://togogenome.org/gene/9555:RAB4A ^@ http://purl.uniprot.org/uniprot/A0A096MWY2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. http://togogenome.org/gene/9555:SEMG2 ^@ http://purl.uniprot.org/uniprot/A4K2M9 ^@ Similarity ^@ Belongs to the semenogelin family. http://togogenome.org/gene/9555:OSTC ^@ http://purl.uniprot.org/uniprot/A0A096MQY6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OSTC family.|||Component of the oligosaccharyltransferase (OST) complex.|||Membrane|||Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1. http://togogenome.org/gene/9555:SUMF2 ^@ http://purl.uniprot.org/uniprot/A0A096NW78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase-modifying factor family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9555:NTS ^@ http://purl.uniprot.org/uniprot/A0A096N6M1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurotensin family.|||Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.|||Secreted|||Vesicle|||secretory vesicle http://togogenome.org/gene/9555:CKS1B ^@ http://purl.uniprot.org/uniprot/A0A2I3LN37 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.|||Forms a homohexamer that can probably bind six kinase subunits. http://togogenome.org/gene/9555:PMEL ^@ http://purl.uniprot.org/uniprot/A0A096NUA0 ^@ Similarity ^@ Belongs to the PMEL/NMB family. http://togogenome.org/gene/9555:IGFBP5 ^@ http://purl.uniprot.org/uniprot/A0A8I5NWX1 ^@ Caution|||Function|||Subcellular Location Annotation ^@ IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9555:MYO1F ^@ http://purl.uniprot.org/uniprot/A0A0A0MWG4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9555:FAIM2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LSN3|||http://purl.uniprot.org/uniprot/A0A2I3MQK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9555:RPF2 ^@ http://purl.uniprot.org/uniprot/A0A8I5R1A1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RPF2 family.|||nucleolus http://togogenome.org/gene/9555:GALE ^@ http://purl.uniprot.org/uniprot/A0A8I5NLW1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family.|||Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.|||Homodimer. http://togogenome.org/gene/9555:ACAD8 ^@ http://purl.uniprot.org/uniprot/A0A096ML57 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9555:CLSTN3 ^@ http://purl.uniprot.org/uniprot/A0A096MRF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calsyntenin family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Postsynaptic cell membrane http://togogenome.org/gene/9555:NAA25 ^@ http://purl.uniprot.org/uniprot/A0A096NXQ6 ^@ Similarity ^@ Belongs to the MDM20/NAA25 family. http://togogenome.org/gene/9555:KCTD2 ^@ http://purl.uniprot.org/uniprot/A0A096NST3 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9555:EVL ^@ http://purl.uniprot.org/uniprot/A0A096NJR0|||http://purl.uniprot.org/uniprot/A0A2I3MIZ9|||http://purl.uniprot.org/uniprot/A0A2I3MRY8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Ena/VASP family.|||Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.|||cytoskeleton http://togogenome.org/gene/9555:IGF2 ^@ http://purl.uniprot.org/uniprot/A9L955 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.|||Secreted http://togogenome.org/gene/9555:RPL9 ^@ http://purl.uniprot.org/uniprot/A0A096MVT0|||http://purl.uniprot.org/uniprot/A0A8I5R904 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/9555:MRPS18C ^@ http://purl.uniprot.org/uniprot/A0A2I3NC38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Mitochondrion http://togogenome.org/gene/9555:SPO11 ^@ http://purl.uniprot.org/uniprot/A0A096NNJ2|||http://purl.uniprot.org/uniprot/A0A2I3MPP3 ^@ Similarity ^@ Belongs to the TOP6A family. http://togogenome.org/gene/9555:RBM15 ^@ http://purl.uniprot.org/uniprot/A0A096N7X1 ^@ Similarity ^@ Belongs to the RRM Spen family. http://togogenome.org/gene/9555:VPS52 ^@ http://purl.uniprot.org/uniprot/A0A096NHH0 ^@ Similarity ^@ Belongs to the VPS52 family. http://togogenome.org/gene/9555:FBXO45 ^@ http://purl.uniprot.org/uniprot/A0A096NXJ8 ^@ Similarity ^@ Belongs to the FBXO45/Fsn family. http://togogenome.org/gene/9555:ATP2C2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LM03 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:SPIRE2 ^@ http://purl.uniprot.org/uniprot/A0A096NRF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the spire family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||cytoskeleton http://togogenome.org/gene/9555:GRPR ^@ http://purl.uniprot.org/uniprot/A0A096N446 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:LOC101016723 ^@ http://purl.uniprot.org/uniprot/A0A2I3MK50 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9555:HSF4 ^@ http://purl.uniprot.org/uniprot/A0A096NJB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/9555:TMED4 ^@ http://purl.uniprot.org/uniprot/A0A096NEZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:CLCN5 ^@ http://purl.uniprot.org/uniprot/A0A096MKP6 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.|||Cell membrane|||Endosome membrane|||Golgi apparatus membrane|||Interacts with NEDD4 and NEDD4L.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:TBCC ^@ http://purl.uniprot.org/uniprot/A0A096MKM5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TBCC family.|||Cytoplasm|||Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state. http://togogenome.org/gene/9555:CTH ^@ http://purl.uniprot.org/uniprot/A0A2I3MWR0 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/9555:SLC7A6 ^@ http://purl.uniprot.org/uniprot/A0A096NFR2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:CAPN7 ^@ http://purl.uniprot.org/uniprot/A0A096MKK7 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9555:STEAP2 ^@ http://purl.uniprot.org/uniprot/B0CM25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9555:EIF4EBP1 ^@ http://purl.uniprot.org/uniprot/A0A096NXN8 ^@ Similarity ^@ Belongs to the eIF4E-binding protein family. http://togogenome.org/gene/9555:TUBB ^@ http://purl.uniprot.org/uniprot/A0A2I3MS98 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9555:LOC101022884 ^@ http://purl.uniprot.org/uniprot/A0A096NFZ5 ^@ Similarity ^@ Belongs to the HSBP1 family. http://togogenome.org/gene/9555:NCF2 ^@ http://purl.uniprot.org/uniprot/A0A2I3NHU8 ^@ Similarity ^@ Belongs to the NCF2/NOXA1 family. http://togogenome.org/gene/9555:SNAP23 ^@ http://purl.uniprot.org/uniprot/A0A096P0C5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP-25 family.|||Cell membrane|||Membrane|||synaptosome http://togogenome.org/gene/9555:CUL1 ^@ http://purl.uniprot.org/uniprot/A0A096N574 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9555:ARL6IP5 ^@ http://purl.uniprot.org/uniprot/A0A096MZH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/9555:PDE6G ^@ http://purl.uniprot.org/uniprot/A0A096NTH2 ^@ Function|||Similarity ^@ Belongs to the rod/cone cGMP-PDE gamma subunit family.|||Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. http://togogenome.org/gene/9555:KRT222 ^@ http://purl.uniprot.org/uniprot/A0A2I3MQW1 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9555:CKM ^@ http://purl.uniprot.org/uniprot/A0A0A0MVC7 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/9555:TOB1 ^@ http://purl.uniprot.org/uniprot/A0A096P4L7 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9555:ZNF280C ^@ http://purl.uniprot.org/uniprot/A0A2I3LW69|||http://purl.uniprot.org/uniprot/A0A8I5NCG2 ^@ Function|||Subcellular Location Annotation ^@ May function as a transcription factor.|||Nucleus http://togogenome.org/gene/9555:CA3 ^@ http://purl.uniprot.org/uniprot/A0A8I5NDT8 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9555:KATNAL1 ^@ http://purl.uniprot.org/uniprot/A9RA82 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.|||Cytoplasm|||Interacts with KATNB1 and KATNBL1.|||Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity). Has microtubule-severing activity in vitro (By similarity).|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/9555:ARF4 ^@ http://purl.uniprot.org/uniprot/A0A096NQ76 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/9555:ERG ^@ http://purl.uniprot.org/uniprot/A0A096NJ30|||http://purl.uniprot.org/uniprot/A0A2I3M4W8|||http://purl.uniprot.org/uniprot/A0A2I3M684|||http://purl.uniprot.org/uniprot/A0A2I3MK98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9555:ELMO2 ^@ http://purl.uniprot.org/uniprot/A0A096NLX7|||http://purl.uniprot.org/uniprot/A0A2I3LXB0 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. http://togogenome.org/gene/9555:GLP1R ^@ http://purl.uniprot.org/uniprot/A0A2I3N226 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:CEP57L1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MCL8 ^@ Similarity ^@ Belongs to the translokin family. http://togogenome.org/gene/9555:CYFIP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MQY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYFIP family.|||synaptosome http://togogenome.org/gene/9555:TM9SF2 ^@ http://purl.uniprot.org/uniprot/A0A2I3NDT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/9555:ARMT1 ^@ http://purl.uniprot.org/uniprot/A0A2I3N2A5 ^@ Domain|||Function|||Similarity ^@ Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.|||Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.|||Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine. http://togogenome.org/gene/9555:RNF182 ^@ http://purl.uniprot.org/uniprot/A0A096MMU1 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with ATP6V0C.|||Membrane http://togogenome.org/gene/9555:TIGD3 ^@ http://purl.uniprot.org/uniprot/A0A096MR01 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:GLS2 ^@ http://purl.uniprot.org/uniprot/A0A096NH12 ^@ Similarity ^@ Belongs to the glutaminase family. http://togogenome.org/gene/9555:KAT2B ^@ http://purl.uniprot.org/uniprot/A0A096NY03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. GCN5 subfamily.|||Nucleus|||centrosome http://togogenome.org/gene/9555:HAAO ^@ http://purl.uniprot.org/uniprot/A0A096N4K0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 3-HAO family.|||Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/9555:PRTFDC1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MM59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/9555:MIOS ^@ http://purl.uniprot.org/uniprot/A0A096NZ52|||http://purl.uniprot.org/uniprot/A0A8I5R6D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat mio family.|||Lysosome membrane http://togogenome.org/gene/9555:YEATS4 ^@ http://purl.uniprot.org/uniprot/A0A2I3LXU5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:PHACTR2 ^@ http://purl.uniprot.org/uniprot/A0A096NGW0|||http://purl.uniprot.org/uniprot/A0A2I3MQN8 ^@ Similarity|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin. http://togogenome.org/gene/9555:OVOL2 ^@ http://purl.uniprot.org/uniprot/A0A096NVN1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:SLC33A1 ^@ http://purl.uniprot.org/uniprot/A0A096NGR1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:GPR87 ^@ http://purl.uniprot.org/uniprot/A0A096MKK8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9555:CMC2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NYA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion http://togogenome.org/gene/9555:GRM5 ^@ http://purl.uniprot.org/uniprot/A0A096MW30|||http://purl.uniprot.org/uniprot/A0A2I3NHK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:CSRNP1 ^@ http://purl.uniprot.org/uniprot/A0A8I5R613 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AXUD1 family.|||Nucleus http://togogenome.org/gene/9555:BRPF1 ^@ http://purl.uniprot.org/uniprot/A0A096NGL6|||http://purl.uniprot.org/uniprot/A0A2I3LLR5|||http://purl.uniprot.org/uniprot/A0A2I3LZ95 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:BLM ^@ http://purl.uniprot.org/uniprot/A0A096NNB3|||http://purl.uniprot.org/uniprot/A0A2I3LVW5 ^@ Similarity ^@ Belongs to the helicase family. RecQ subfamily. http://togogenome.org/gene/9555:AQP7 ^@ http://purl.uniprot.org/uniprot/A0A096P1C3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9555:DHX9 ^@ http://purl.uniprot.org/uniprot/A0A096NWR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DEAH subfamily.|||Nucleus http://togogenome.org/gene/9555:EMC6 ^@ http://purl.uniprot.org/uniprot/A0A096NRU1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC6 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:EMP2 ^@ http://purl.uniprot.org/uniprot/A0A096NLN2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the PMP-22/EMP/MP20 family.|||Cell membrane|||Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion.|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Membrane raft|||Nucleus|||perinuclear region http://togogenome.org/gene/9555:TEF ^@ http://purl.uniprot.org/uniprot/A0A8I5NEP4|||http://purl.uniprot.org/uniprot/A0A8I5P453 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/9555:FLCN ^@ http://purl.uniprot.org/uniprot/A0A8I5R2S5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the folliculin family.|||Lysosome membrane|||Membrane|||Nucleus|||centrosome|||cilium|||cytosol|||spindle http://togogenome.org/gene/9555:RFX2 ^@ http://purl.uniprot.org/uniprot/A0A0A0MVN4|||http://purl.uniprot.org/uniprot/A0A2I3MBG1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:YTHDC1 ^@ http://purl.uniprot.org/uniprot/A0A096MLF1|||http://purl.uniprot.org/uniprot/A0A2I3N4A7 ^@ Function|||Similarity ^@ Belongs to the YTHDF family.|||Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. http://togogenome.org/gene/9555:WDR12 ^@ http://purl.uniprot.org/uniprot/A0A096MS96 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat WDR12/YTM1 family.|||Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.|||Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9555:TMEM121 ^@ http://purl.uniprot.org/uniprot/A0A096MPM1 ^@ Similarity ^@ Belongs to the TMEM121 family. http://togogenome.org/gene/9555:SLC43A2 ^@ http://purl.uniprot.org/uniprot/A0A096P2A1|||http://purl.uniprot.org/uniprot/A0A2I3MF50 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:TMED5 ^@ http://purl.uniprot.org/uniprot/A0A096MZU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9555:GSTO2 ^@ http://purl.uniprot.org/uniprot/A0A096P6I8|||http://purl.uniprot.org/uniprot/A0A2I3LI68 ^@ Function|||Similarity ^@ Belongs to the GST superfamily. Omega family.|||Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). http://togogenome.org/gene/9555:PYY ^@ http://purl.uniprot.org/uniprot/A0A096P5Z1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Secreted http://togogenome.org/gene/9555:ERI1 ^@ http://purl.uniprot.org/uniprot/A0A096MZD1|||http://purl.uniprot.org/uniprot/A0A8I5NIU5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:HKDC1 ^@ http://purl.uniprot.org/uniprot/A0A096P4Z5 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/9555:PFKL ^@ http://purl.uniprot.org/uniprot/A0A096NIG0 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homo- and heterotetramers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:IGFBP1 ^@ http://purl.uniprot.org/uniprot/A0A8I5MZC8 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Binds equally well IGF1 and IGF2.|||IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9555:RPS21 ^@ http://purl.uniprot.org/uniprot/A0A096NNB2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS21 family.|||Component of the 40S small ribosomal subunit.|||Endoplasmic reticulum|||Rough endoplasmic reticulum|||cytosol http://togogenome.org/gene/9555:MTFR2 ^@ http://purl.uniprot.org/uniprot/A0A096NQW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission. http://togogenome.org/gene/9555:LOC101000710 ^@ http://purl.uniprot.org/uniprot/A0A096NQY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OXA1/ALB3/YidC family.|||Membrane http://togogenome.org/gene/9555:CDS1 ^@ http://purl.uniprot.org/uniprot/A0A096N694 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Membrane http://togogenome.org/gene/9555:TMEM178B ^@ http://purl.uniprot.org/uniprot/A0A2I3MYC7 ^@ Similarity ^@ Belongs to the TMEM178 family. http://togogenome.org/gene/9555:CREBBP ^@ http://purl.uniprot.org/uniprot/A0A096NLD5|||http://purl.uniprot.org/uniprot/A0A096NLD6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:NAP1L5 ^@ http://purl.uniprot.org/uniprot/A0A096N2I1 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9555:FN3KRP ^@ http://purl.uniprot.org/uniprot/A0A096NTQ1 ^@ Similarity ^@ Belongs to the fructosamine kinase family. http://togogenome.org/gene/9555:PAFAH1B1 ^@ http://purl.uniprot.org/uniprot/A0A096P2D3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat LIS1/nudF family.|||Can self-associate. Interacts with DCX, dynein, dynactin, IQGAP1, KATNB1, NDE1, NDEL1, NUDC and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling. Component of cytosolic PAF-AH IB, which is composed of PAFAH1B1 (alpha), PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits. Trimer formation is not essential for the catalytic activity of the enzyme which is contributed solely by the PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits.|||Dimerization mediated by the LisH domain may be required to activate dynein.|||Nucleus membrane|||Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position.|||centrosome|||cytoskeleton|||spindle http://togogenome.org/gene/9555:VAC14 ^@ http://purl.uniprot.org/uniprot/A0A2I3MIB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VAC14 family.|||Endosome membrane|||Microsome membrane http://togogenome.org/gene/9555:MAPK1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LQV7 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.|||caveola|||focal adhesion http://togogenome.org/gene/9555:GABRB2 ^@ http://purl.uniprot.org/uniprot/A0A096MNJ0|||http://purl.uniprot.org/uniprot/A0A2I3N1S0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9555:SLC17A4 ^@ http://purl.uniprot.org/uniprot/A0A096NLE8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:SLC50A1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LQ77|||http://purl.uniprot.org/uniprot/A0A2I3MVA4|||http://purl.uniprot.org/uniprot/Q95KW8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SWEET sugar transporter family.|||Cell membrane|||Golgi apparatus membrane|||Interacts with TRPV2; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation.|||Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1 (By similarity).|||Membrane http://togogenome.org/gene/9555:ROPN1L ^@ http://purl.uniprot.org/uniprot/A0A2I3LQU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ropporin family.|||flagellum http://togogenome.org/gene/9555:UBE2L5 ^@ http://purl.uniprot.org/uniprot/A9RA83 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9555:IL9 ^@ http://purl.uniprot.org/uniprot/A0A096N5D0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-7/IL-9 family.|||Secreted http://togogenome.org/gene/9555:B9D2 ^@ http://purl.uniprot.org/uniprot/A0A0A0MVF1 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/9555:RTRAF ^@ http://purl.uniprot.org/uniprot/A0A8I5R6Y5 ^@ Similarity ^@ Belongs to the RTRAF family. http://togogenome.org/gene/9555:FURIN ^@ http://purl.uniprot.org/uniprot/A0A096NK79 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9555:CACNG6 ^@ http://purl.uniprot.org/uniprot/A0A0A0MUR6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane|||Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. http://togogenome.org/gene/9555:PCMTD1 ^@ http://purl.uniprot.org/uniprot/A0A096MXP2|||http://purl.uniprot.org/uniprot/A0A2I3MQT8 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/9555:B3GNT5 ^@ http://purl.uniprot.org/uniprot/A0A096MYV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9555:DR1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LLP5 ^@ Similarity ^@ Belongs to the NC2 beta/DR1 family. http://togogenome.org/gene/9555:HTR3B ^@ http://purl.uniprot.org/uniprot/A0A096NGY7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9555:LOC101021583 ^@ http://purl.uniprot.org/uniprot/A0A096NFZ7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:TLE3 ^@ http://purl.uniprot.org/uniprot/A0A096NMK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat Groucho/TLE family.|||Nucleus http://togogenome.org/gene/9555:MACIR ^@ http://purl.uniprot.org/uniprot/A0A096NBZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UNC119-binding protein family.|||Cytoplasm|||cilium http://togogenome.org/gene/9555:MRPL36 ^@ http://purl.uniprot.org/uniprot/A0A8I5P175 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/9555:TRIM38 ^@ http://purl.uniprot.org/uniprot/A0A096NLF9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9555:CHMP2B ^@ http://purl.uniprot.org/uniprot/A0A2I3LJE6 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9555:SLC16A6 ^@ http://purl.uniprot.org/uniprot/A0A096NU02 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:CAPN2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NH07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C2 family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9555:SASS6 ^@ http://purl.uniprot.org/uniprot/A0A096MRG9|||http://purl.uniprot.org/uniprot/A0A8I5R0V3 ^@ Subcellular Location Annotation ^@ centrosome http://togogenome.org/gene/9555:F11R ^@ http://purl.uniprot.org/uniprot/A0A096N4D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9555:EBP ^@ http://purl.uniprot.org/uniprot/A0A096NAT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:PPP2R5B ^@ http://purl.uniprot.org/uniprot/B0CM71 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9555:CENPK ^@ http://purl.uniprot.org/uniprot/A0A096N924 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-K/MCM22 family.|||Nucleus|||centromere http://togogenome.org/gene/9555:TREX2 ^@ http://purl.uniprot.org/uniprot/A0A096N6A8 ^@ Similarity ^@ Belongs to the exonuclease superfamily. TREX family. http://togogenome.org/gene/9555:MED30 ^@ http://purl.uniprot.org/uniprot/A0A096NDR6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 30 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/9555:SF3B6 ^@ http://purl.uniprot.org/uniprot/A0A096MYT4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:NDC1 ^@ http://purl.uniprot.org/uniprot/A0A096N2H0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDC1 family.|||Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.|||Membrane|||Nucleus membrane|||nuclear pore complex http://togogenome.org/gene/9555:LOC101016144 ^@ http://purl.uniprot.org/uniprot/A0A8I5NHQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:XAGE5 ^@ http://purl.uniprot.org/uniprot/A0A096MLD1 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9555:MEX3B ^@ http://purl.uniprot.org/uniprot/A0A8I5N2I6 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9555:SNAP25 ^@ http://purl.uniprot.org/uniprot/A0A096NVI2|||http://purl.uniprot.org/uniprot/A0A2I3MH75 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNAP-25 family.|||Cell membrane|||Membrane|||Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.|||Photoreceptor inner segment|||synaptosome|||t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. http://togogenome.org/gene/9555:CDH19 ^@ http://purl.uniprot.org/uniprot/A0A096ML04 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:MAPK13 ^@ http://purl.uniprot.org/uniprot/A0A2I3NCE1 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Interacts with MAPK8IP2. http://togogenome.org/gene/9555:CXCL9 ^@ http://purl.uniprot.org/uniprot/A0A8I5NZ72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9555:MRFAP1 ^@ http://purl.uniprot.org/uniprot/A0A096N9G1 ^@ Similarity ^@ Belongs to the MORF4 family-associated protein family. http://togogenome.org/gene/9555:FUNDC2 ^@ http://purl.uniprot.org/uniprot/A0A2I3NG93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FUN14 family.|||Mitochondrion outer membrane http://togogenome.org/gene/9555:VEGFB ^@ http://purl.uniprot.org/uniprot/A0A2I3LCN1|||http://purl.uniprot.org/uniprot/A0A2I3LL73 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/9555:SMIM19 ^@ http://purl.uniprot.org/uniprot/A0A096N1H3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM19 family.|||Membrane http://togogenome.org/gene/9555:NDP ^@ http://purl.uniprot.org/uniprot/A0A8I5NXV3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9555:SMG7 ^@ http://purl.uniprot.org/uniprot/A0A8I5NQA0 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Plays a role in nonsense-mediated mRNA decay. http://togogenome.org/gene/9555:MTMR12 ^@ http://purl.uniprot.org/uniprot/A0A2I3MGU8 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9555:LOC101010784 ^@ http://purl.uniprot.org/uniprot/A9RA98 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:TSPYL4 ^@ http://purl.uniprot.org/uniprot/A0A2I3NC01 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9555:NAA60 ^@ http://purl.uniprot.org/uniprot/A0A096NLC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. NAA60 subfamily.|||Golgi apparatus membrane http://togogenome.org/gene/9555:MUS81 ^@ http://purl.uniprot.org/uniprot/A0A096N654 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XPF family.|||Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).|||Interacts with EME1.|||Nucleus http://togogenome.org/gene/9555:WDR82 ^@ http://purl.uniprot.org/uniprot/A0A096NSF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SWD2 family.|||Nucleus http://togogenome.org/gene/9555:COX1 ^@ http://purl.uniprot.org/uniprot/K9MVI0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:OLFR633 ^@ http://purl.uniprot.org/uniprot/A9L8Y5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:RPS19 ^@ http://purl.uniprot.org/uniprot/A0A096N169 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS19 family. http://togogenome.org/gene/9555:SLC18A3 ^@ http://purl.uniprot.org/uniprot/A0A096N6N1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:POFUT1 ^@ http://purl.uniprot.org/uniprot/A0A096NUY4|||http://purl.uniprot.org/uniprot/A0A2I3LUM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 65 family.|||Endoplasmic reticulum http://togogenome.org/gene/9555:CRABP2 ^@ http://purl.uniprot.org/uniprot/A0A096N409 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9555:SHMT1 ^@ http://purl.uniprot.org/uniprot/A0A096P337 ^@ Function|||Similarity ^@ Belongs to the SHMT family.|||Interconversion of serine and glycine. http://togogenome.org/gene/9555:NHS ^@ http://purl.uniprot.org/uniprot/A0A8I5P0E5 ^@ Similarity ^@ Belongs to the NHS family. http://togogenome.org/gene/9555:TMEM170B ^@ http://purl.uniprot.org/uniprot/A0A2I3NHQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM170 family.|||Membrane http://togogenome.org/gene/9555:TSPAN14 ^@ http://purl.uniprot.org/uniprot/A0A8I5R1Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9555:TMEM167B ^@ http://purl.uniprot.org/uniprot/A0A096N7X2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KISH family.|||Golgi apparatus membrane|||Involved in the early part of the secretory pathway.|||Membrane http://togogenome.org/gene/9555:IP6K3 ^@ http://purl.uniprot.org/uniprot/A0A8I5NG88 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9555:HOXC6 ^@ http://purl.uniprot.org/uniprot/A0A2I3MZ73 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:ITGAV ^@ http://purl.uniprot.org/uniprot/A0A2I3N2W4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9555:MED15 ^@ http://purl.uniprot.org/uniprot/A0A096NS57|||http://purl.uniprot.org/uniprot/A0A2I3N6Y6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 15 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9555:SPCS3 ^@ http://purl.uniprot.org/uniprot/A0A096MLE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS3 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:COPS6 ^@ http://purl.uniprot.org/uniprot/A0A096N153 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M67A family. CSN6 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:FLNA ^@ http://purl.uniprot.org/uniprot/A9CB59 ^@ Similarity ^@ Belongs to the filamin family. http://togogenome.org/gene/9555:LIX1 ^@ http://purl.uniprot.org/uniprot/A0A096N5D3 ^@ Similarity ^@ Belongs to the LIX1 family. http://togogenome.org/gene/9555:SH3BP4 ^@ http://purl.uniprot.org/uniprot/A0A096N1P2 ^@ Subcellular Location Annotation ^@ Nucleus|||Vesicle|||clathrin-coated pit|||clathrin-coated vesicle http://togogenome.org/gene/9555:GTF2A1 ^@ http://purl.uniprot.org/uniprot/A0A096NRB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 1 family.|||Nucleus http://togogenome.org/gene/9555:NAA30 ^@ http://purl.uniprot.org/uniprot/A0A8I5NG78 ^@ Similarity ^@ Belongs to the acetyltransferase family. MAK3 subfamily. http://togogenome.org/gene/9555:LOC101025167 ^@ http://purl.uniprot.org/uniprot/A0A096NNQ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M24 family. SPT16 subfamily.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Component of the FACT complex.|||Nucleus http://togogenome.org/gene/9555:MPP4 ^@ http://purl.uniprot.org/uniprot/A0A096N425 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/9555:CHCHD6 ^@ http://purl.uniprot.org/uniprot/A0A096N2I2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic25 subfamily.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:ROM1 ^@ http://purl.uniprot.org/uniprot/A0A096NGZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRPH2/ROM1 family.|||Membrane http://togogenome.org/gene/9555:PPP6R3 ^@ http://purl.uniprot.org/uniprot/A0A096NAW4|||http://purl.uniprot.org/uniprot/A0A2I3M022|||http://purl.uniprot.org/uniprot/A0A2I3MAQ7|||http://purl.uniprot.org/uniprot/A0A2I3MJ12 ^@ Similarity ^@ Belongs to the SAPS family. http://togogenome.org/gene/9555:AK3 ^@ http://purl.uniprot.org/uniprot/A0A096P1M3|||http://purl.uniprot.org/uniprot/A0A2I3MZW5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Belongs to the adenylate kinase family. AK3 subfamily.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.|||Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.|||Mitochondrion matrix|||Monomer. http://togogenome.org/gene/9555:FTMT ^@ http://purl.uniprot.org/uniprot/A0A8I5MXU5 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/9555:MYO1B ^@ http://purl.uniprot.org/uniprot/A0A2I3NB04|||http://purl.uniprot.org/uniprot/A0A2I3NF97 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9555:ETFDH ^@ http://purl.uniprot.org/uniprot/A0A2I3LQT4 ^@ Cofactor|||Function ^@ Accepts electrons from ETF and reduces ubiquinone.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/9555:GALM ^@ http://purl.uniprot.org/uniprot/A0A096MYS2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the aldose epimerase family.|||Monomer.|||Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. http://togogenome.org/gene/9555:DYNC1I1 ^@ http://purl.uniprot.org/uniprot/A0A2I3M795|||http://purl.uniprot.org/uniprot/A0A8I5N0H5 ^@ Similarity ^@ Belongs to the dynein intermediate chain family. http://togogenome.org/gene/9555:RORA ^@ http://purl.uniprot.org/uniprot/A0A2I3ND74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9555:BICD1 ^@ http://purl.uniprot.org/uniprot/A0A096N9C7|||http://purl.uniprot.org/uniprot/A0A2I3LEN0 ^@ Similarity ^@ Belongs to the BicD family. http://togogenome.org/gene/9555:GGH ^@ http://purl.uniprot.org/uniprot/A0A8I5NTG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C26 family.|||extracellular space http://togogenome.org/gene/9555:LOC101021735 ^@ http://purl.uniprot.org/uniprot/A0A2I3MLC4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:TGFB3 ^@ http://purl.uniprot.org/uniprot/A0A096NS60 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.|||extracellular matrix http://togogenome.org/gene/9555:PARVB ^@ http://purl.uniprot.org/uniprot/A0A096NKK4|||http://purl.uniprot.org/uniprot/A0A2I3M295|||http://purl.uniprot.org/uniprot/A0A8I5RA36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the parvin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:PELI1 ^@ http://purl.uniprot.org/uniprot/A0A096P060 ^@ Function|||Similarity ^@ Belongs to the pellino family.|||E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. http://togogenome.org/gene/9555:RPAIN ^@ http://purl.uniprot.org/uniprot/A0A2I3LCK1|||http://purl.uniprot.org/uniprot/A0A2I3N405 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:UGT1A5B ^@ http://purl.uniprot.org/uniprot/Q20CL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9555:RCE1 ^@ http://purl.uniprot.org/uniprot/A0A096MSC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase U48 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:PGF ^@ http://purl.uniprot.org/uniprot/A0A096NQB0|||http://purl.uniprot.org/uniprot/A0A2I3MWB0 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/9555:FAM118B ^@ http://purl.uniprot.org/uniprot/A0A096N6W3 ^@ Similarity ^@ Belongs to the FAM118 family. http://togogenome.org/gene/9555:NPPC ^@ http://purl.uniprot.org/uniprot/A0A096NXK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the natriuretic peptide family.|||Secreted http://togogenome.org/gene/9555:ZDHHC9 ^@ http://purl.uniprot.org/uniprot/A0A8I5NY33 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9555:SLC17A2 ^@ http://purl.uniprot.org/uniprot/A0A096NLF6|||http://purl.uniprot.org/uniprot/A0A2I3LQ19|||http://purl.uniprot.org/uniprot/A0A8I5NK71 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:DMPK ^@ http://purl.uniprot.org/uniprot/A0A0A0MXK6|||http://purl.uniprot.org/uniprot/A0A2I3N2L9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily. http://togogenome.org/gene/9555:BABAM2 ^@ http://purl.uniprot.org/uniprot/A0A096P085|||http://purl.uniprot.org/uniprot/A0A2I3LWZ3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BABAM2 family.|||Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.|||Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.|||Cytoplasm|||May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.|||Nucleus http://togogenome.org/gene/9555:PIGP ^@ http://purl.uniprot.org/uniprot/A0A096NJ45 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGP family.|||Membrane|||Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. http://togogenome.org/gene/9555:SPIC ^@ http://purl.uniprot.org/uniprot/A0A2I3NDG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9555:SIRT4 ^@ http://purl.uniprot.org/uniprot/A0A096MZT3 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ According to some authors, ADP-ribosyltransferase activity of sirtuins may be an inefficient side reaction of the deacetylase activity and may not be physiologically relevant.|||Acts as NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Does not seem to deacetylate PC. Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels. Down-regulates insulin secretion.|||Belongs to the sirtuin family. Class II subfamily.|||Binds 1 zinc ion per subunit.|||Interacts with GLUD1, IDE and SLC25A5. Interacts with DLAT and PDHX.|||Mitochondrion matrix http://togogenome.org/gene/9555:TPK1 ^@ http://purl.uniprot.org/uniprot/A0A096NZ41 ^@ Similarity ^@ Belongs to the thiamine pyrophosphokinase family. http://togogenome.org/gene/9555:TFEB ^@ http://purl.uniprot.org/uniprot/A8MN25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/9555:DAZL ^@ http://purl.uniprot.org/uniprot/A0A096MPX8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:SH2B1 ^@ http://purl.uniprot.org/uniprot/A0A096NHN2|||http://purl.uniprot.org/uniprot/A0A2I3M9E3 ^@ Similarity ^@ Belongs to the SH2B adapter family. http://togogenome.org/gene/9555:UFL1 ^@ http://purl.uniprot.org/uniprot/A0A096MVC6 ^@ Similarity ^@ Belongs to the UFL1 family. http://togogenome.org/gene/9555:VAT1 ^@ http://purl.uniprot.org/uniprot/A0A096P5X1 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/9555:PIAS4 ^@ http://purl.uniprot.org/uniprot/A0A0A0MWY6 ^@ Similarity ^@ Belongs to the PIAS family. http://togogenome.org/gene/9555:CFAP300 ^@ http://purl.uniprot.org/uniprot/A0A2I3NE63 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP300 family.|||Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.|||Cytoplasm http://togogenome.org/gene/9555:PPP1CA ^@ http://purl.uniprot.org/uniprot/A0A096NBP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family. PP-1 subfamily.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9555:CHST6 ^@ http://purl.uniprot.org/uniprot/A0A096N7J5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/9555:KCNH3 ^@ http://purl.uniprot.org/uniprot/A0A096MP06 ^@ Subcellular Location Annotation|||Subunit ^@ Membrane|||The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. http://togogenome.org/gene/9555:ACP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MSC9|||http://purl.uniprot.org/uniprot/A0A8I5R2N5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.|||Belongs to the low molecular weight phosphotyrosine protein phosphatase family.|||Cytoplasm http://togogenome.org/gene/9555:KCTD17 ^@ http://purl.uniprot.org/uniprot/A0A096NJU9|||http://purl.uniprot.org/uniprot/A0A2I3LNB4|||http://purl.uniprot.org/uniprot/A0A2I3M0A5 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9555:DYNLT1 ^@ http://purl.uniprot.org/uniprot/A0A096NRM7 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/9555:AREG ^@ http://purl.uniprot.org/uniprot/A0A096MTK2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:SLC25A42 ^@ http://purl.uniprot.org/uniprot/A0A0A0MUE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9555:ALKBH6 ^@ http://purl.uniprot.org/uniprot/A0A0A0MVF5 ^@ Similarity ^@ Belongs to the alkB family. http://togogenome.org/gene/9555:TMEM151B ^@ http://purl.uniprot.org/uniprot/A0A096NIM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM151 family.|||Membrane http://togogenome.org/gene/9555:AZIN2 ^@ http://purl.uniprot.org/uniprot/A0A096N719 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/9555:BEND6 ^@ http://purl.uniprot.org/uniprot/A0A096N2R6|||http://purl.uniprot.org/uniprot/A0A2I3LGI4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:MS4A5 ^@ http://purl.uniprot.org/uniprot/A0A096MPS7 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9555:CBX5 ^@ http://purl.uniprot.org/uniprot/A0A2I3LLL9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:TIMM10B ^@ http://purl.uniprot.org/uniprot/A0A8I5MUQ9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9555:NFIX ^@ http://purl.uniprot.org/uniprot/A0A0A0MVZ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTF/NF-I family.|||Binds DNA as a homodimer.|||Nucleus|||Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. http://togogenome.org/gene/9555:UBE2G2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LSR7 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9555:SLC23A2 ^@ http://purl.uniprot.org/uniprot/A0A096NVD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.|||Membrane http://togogenome.org/gene/9555:SLC25A35 ^@ http://purl.uniprot.org/uniprot/A0A2I3NGL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9555:MMP10 ^@ http://purl.uniprot.org/uniprot/A0A096N6W9 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9555:AFF4 ^@ http://purl.uniprot.org/uniprot/A0A8I5N6A9|||http://purl.uniprot.org/uniprot/A9CB20 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/9555:PLD3 ^@ http://purl.uniprot.org/uniprot/A0A0A0MUV5 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/9555:APMAP ^@ http://purl.uniprot.org/uniprot/A0A8I5NIL8 ^@ Similarity ^@ Belongs to the strictosidine synthase family. http://togogenome.org/gene/9555:SLC7A2 ^@ http://purl.uniprot.org/uniprot/A0A096NA16|||http://purl.uniprot.org/uniprot/A0A2I3LK77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:LOC101006632 ^@ http://purl.uniprot.org/uniprot/A0A096NLE4 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/9555:FAM110A ^@ http://purl.uniprot.org/uniprot/A0A096N0M2 ^@ Similarity ^@ Belongs to the FAM110 family. http://togogenome.org/gene/9555:RPL13A ^@ http://purl.uniprot.org/uniprot/A0A0A0MW64 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/9555:PSD2 ^@ http://purl.uniprot.org/uniprot/A0A096MP76 ^@ Subcellular Location Annotation ^@ Membrane|||ruffle membrane http://togogenome.org/gene/9555:DDI2 ^@ http://purl.uniprot.org/uniprot/A0A096MWC1 ^@ Similarity ^@ Belongs to the DDI1 family. http://togogenome.org/gene/9555:ALX4 ^@ http://purl.uniprot.org/uniprot/A0A096N4Y9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:TGIF1 ^@ http://purl.uniprot.org/uniprot/A0A096MXB7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:SLC40A1 ^@ http://purl.uniprot.org/uniprot/A0A096NY75 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lateral cell membrane|||May be involved in iron transport and iron homeostasis.|||Membrane http://togogenome.org/gene/9555:SKAP1 ^@ http://purl.uniprot.org/uniprot/A0A096P420 ^@ Similarity ^@ Belongs to the SKAP family. http://togogenome.org/gene/9555:ING3 ^@ http://purl.uniprot.org/uniprot/A0A096MVW9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9555:FABP2 ^@ http://purl.uniprot.org/uniprot/A0A096MX76 ^@ Function|||Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor. http://togogenome.org/gene/9555:HSPB6 ^@ http://purl.uniprot.org/uniprot/A0A0A0MXH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Nucleus http://togogenome.org/gene/9555:AVIL ^@ http://purl.uniprot.org/uniprot/A0A096N7M3 ^@ Similarity ^@ Belongs to the villin/gelsolin family. http://togogenome.org/gene/9555:TASP1 ^@ http://purl.uniprot.org/uniprot/A0A096NVJ6 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/9555:COPS7A ^@ http://purl.uniprot.org/uniprot/A0A096N053 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:WNT7B ^@ http://purl.uniprot.org/uniprot/A0A8I5MYN7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9555:RUNDC3A ^@ http://purl.uniprot.org/uniprot/A0A096P609|||http://purl.uniprot.org/uniprot/A0A2I3MFH1 ^@ Similarity ^@ Belongs to the RUNDC3 family. http://togogenome.org/gene/9555:TMEM39A ^@ http://purl.uniprot.org/uniprot/A0A096MWM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM39 family.|||Membrane http://togogenome.org/gene/9555:SLC25A36 ^@ http://purl.uniprot.org/uniprot/A0A2I3N4U4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9555:ALOX15 ^@ http://purl.uniprot.org/uniprot/A0A096P2G1 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the lipoxygenase family.|||Binds 1 Fe cation per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:ANAPC15 ^@ http://purl.uniprot.org/uniprot/A0A2I3LKQ0 ^@ Similarity ^@ Belongs to the APC15 family. http://togogenome.org/gene/9555:CHST9 ^@ http://purl.uniprot.org/uniprot/A0A096N419|||http://purl.uniprot.org/uniprot/A0A2I3NDM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9555:TRNAU1AP ^@ http://purl.uniprot.org/uniprot/A0A096MLY3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TRSPAP family.|||Cytoplasm|||Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis.|||Nucleus http://togogenome.org/gene/9555:GATAD2A ^@ http://purl.uniprot.org/uniprot/A0A0A0MVQ6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:COPZ2 ^@ http://purl.uniprot.org/uniprot/A0A096P415 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes small subunit family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. http://togogenome.org/gene/9555:EDEM2 ^@ http://purl.uniprot.org/uniprot/A0A096NUQ6|||http://purl.uniprot.org/uniprot/A0A2I3MIJ9|||http://purl.uniprot.org/uniprot/A0A8I5NDP4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9555:RCAN2 ^@ http://purl.uniprot.org/uniprot/A0A096NIS1 ^@ Function|||Similarity ^@ Belongs to the RCAN family.|||Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. http://togogenome.org/gene/9555:AMOTL1 ^@ http://purl.uniprot.org/uniprot/A0A096N340|||http://purl.uniprot.org/uniprot/A0A8I5N5J2 ^@ Similarity ^@ Belongs to the angiomotin family. http://togogenome.org/gene/9555:SBF2 ^@ http://purl.uniprot.org/uniprot/A0A096NFW7 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9555:NUS1 ^@ http://purl.uniprot.org/uniprot/A0A8I5N6M2 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/9555:SHQ1 ^@ http://purl.uniprot.org/uniprot/A0A096NPD3 ^@ Similarity ^@ Belongs to the SHQ1 family. http://togogenome.org/gene/9555:LBX1 ^@ http://purl.uniprot.org/uniprot/A0A096P6B5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:NR2E1 ^@ http://purl.uniprot.org/uniprot/B0CM45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9555:MVB12A ^@ http://purl.uniprot.org/uniprot/A0A2I3MTA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MVB12 family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9555:BARX2 ^@ http://purl.uniprot.org/uniprot/A0A096NDG7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:MMD2 ^@ http://purl.uniprot.org/uniprot/A0A096NDN8|||http://purl.uniprot.org/uniprot/A0A2I3LPP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9555:MRPL12 ^@ http://purl.uniprot.org/uniprot/A0A096NTH9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL12 family. http://togogenome.org/gene/9555:CAD ^@ http://purl.uniprot.org/uniprot/A0A096MNE6 ^@ Similarity ^@ In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily. http://togogenome.org/gene/9555:CDO1 ^@ http://purl.uniprot.org/uniprot/A0A096MZR3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the cysteine dioxygenase family.|||Binds 1 Fe cation per subunit.|||Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen. http://togogenome.org/gene/9555:ADAM23 ^@ http://purl.uniprot.org/uniprot/A0A096MTA0|||http://purl.uniprot.org/uniprot/A0A2I3LD73|||http://purl.uniprot.org/uniprot/A0A2I3N9Z0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:EXOSC1 ^@ http://purl.uniprot.org/uniprot/A0A096P606 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:BCL2L13 ^@ http://purl.uniprot.org/uniprot/A0A096NVY6 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9555:VSIG1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MGW0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:SLC4A2 ^@ http://purl.uniprot.org/uniprot/A0A096N5Q5|||http://purl.uniprot.org/uniprot/A0A2I3LR53|||http://purl.uniprot.org/uniprot/A0A2I3M8T7 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:GRIK3 ^@ http://purl.uniprot.org/uniprot/A0A2I3MF13 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/9555:TM9SF4 ^@ http://purl.uniprot.org/uniprot/A0A2I3MQ43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/9555:SPCS1 ^@ http://purl.uniprot.org/uniprot/A0A096MXK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:EHD1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MY97|||http://purl.uniprot.org/uniprot/B0CM69 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/9555:DIP2A ^@ http://purl.uniprot.org/uniprot/A0A096NI71 ^@ Similarity ^@ Belongs to the DIP2 family. http://togogenome.org/gene/9555:EYA3 ^@ http://purl.uniprot.org/uniprot/A0A2I3N5L1 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/9555:VIPR1 ^@ http://purl.uniprot.org/uniprot/A0A096MT91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:LOC101021556 ^@ http://purl.uniprot.org/uniprot/A0A096MLB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:GDE1 ^@ http://purl.uniprot.org/uniprot/A0A096NUJ5 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9555:ACSS1 ^@ http://purl.uniprot.org/uniprot/A0A096NVU8 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9555:ARRDC2 ^@ http://purl.uniprot.org/uniprot/A0A0A0MWG7 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9555:TMEM150A ^@ http://purl.uniprot.org/uniprot/A0A096NZV1|||http://purl.uniprot.org/uniprot/A0A2I3LHS8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:TP53 ^@ http://purl.uniprot.org/uniprot/A0A096P2R8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.|||Belongs to the p53 family.|||Binds 1 zinc ion per subunit.|||Binds DNA as a homotetramer.|||Cytoplasm|||Endoplasmic reticulum|||Mitochondrion matrix|||Nucleus|||PML body|||centrosome http://togogenome.org/gene/9555:SH3GL3 ^@ http://purl.uniprot.org/uniprot/A0A2I3N7A0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Membrane http://togogenome.org/gene/9555:NRF1 ^@ http://purl.uniprot.org/uniprot/A0A096NYC1|||http://purl.uniprot.org/uniprot/A0A2I3N2S1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NRF1/Ewg family.|||Nucleus http://togogenome.org/gene/9555:TYRO3 ^@ http://purl.uniprot.org/uniprot/A0A2I3MGB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.|||Membrane http://togogenome.org/gene/9555:LOC101013836 ^@ http://purl.uniprot.org/uniprot/A0A096N7J3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:PHOSPHO2 ^@ http://purl.uniprot.org/uniprot/A0A096MMF1 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. PHOSPHO family. http://togogenome.org/gene/9555:C1D ^@ http://purl.uniprot.org/uniprot/A0A096MS73 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the C1D family.|||Cytoplasm|||Monomer and homodimer.|||Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.|||nucleolus http://togogenome.org/gene/9555:IAPP ^@ http://purl.uniprot.org/uniprot/A0A096NFS7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calcitonin family.|||Secreted|||Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. http://togogenome.org/gene/9555:WFIKKN2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LXY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WFIKKN family.|||Secreted http://togogenome.org/gene/9555:PPP4C ^@ http://purl.uniprot.org/uniprot/A0A8I5NIV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/9555:NFYB ^@ http://purl.uniprot.org/uniprot/A0A096ND24 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NFYB/HAP3 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.|||Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP. http://togogenome.org/gene/9555:TRIM22 ^@ http://purl.uniprot.org/uniprot/A9L8Z5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:SLC66A2 ^@ http://purl.uniprot.org/uniprot/A0A096N955|||http://purl.uniprot.org/uniprot/A0A2I3LF97|||http://purl.uniprot.org/uniprot/A0A8I5N599 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:MGAT4A ^@ http://purl.uniprot.org/uniprot/A0A096NVZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 54 family.|||Golgi apparatus membrane http://togogenome.org/gene/9555:TBX5 ^@ http://purl.uniprot.org/uniprot/A0A096MUP3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9555:NOP10 ^@ http://purl.uniprot.org/uniprot/A0A8I5NJL7 ^@ Similarity ^@ Belongs to the NOP10 family. http://togogenome.org/gene/9555:CAMK2A ^@ http://purl.uniprot.org/uniprot/A0A2I3MCB0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9555:RBKS ^@ http://purl.uniprot.org/uniprot/A0A096P083|||http://purl.uniprot.org/uniprot/A0A8I5NHM9 ^@ Activity Regulation|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Belongs to the carbohydrate kinase pfkB family.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Nucleus|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/9555:C20H19orf12 ^@ http://purl.uniprot.org/uniprot/A0A0A0MWG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the C19orf12 family.|||Mitochondrion membrane http://togogenome.org/gene/9555:LOC101001645 ^@ http://purl.uniprot.org/uniprot/A0A8I5NFE1 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9555:OLFML1 ^@ http://purl.uniprot.org/uniprot/A0A8I5N4E7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:RBBP5 ^@ http://purl.uniprot.org/uniprot/A0A096NH14 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:TOM1L1 ^@ http://purl.uniprot.org/uniprot/A0A096P4N8 ^@ Similarity ^@ Belongs to the TOM1 family. http://togogenome.org/gene/9555:LOC101022490 ^@ http://purl.uniprot.org/uniprot/A0A2I3LCL1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS10 family. http://togogenome.org/gene/9555:CNOT9 ^@ http://purl.uniprot.org/uniprot/A0A2I3MEP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT9 family.|||P-body http://togogenome.org/gene/9555:PHB2 ^@ http://purl.uniprot.org/uniprot/A0A2I3M437 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Cell membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:LIN7C ^@ http://purl.uniprot.org/uniprot/A0A2I3MG07 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the lin-7 family.|||Cell membrane|||Lateral cell membrane|||Membrane|||Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.|||Postsynaptic density membrane|||tight junction http://togogenome.org/gene/9555:PSMG2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LY64 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PSMG2 family.|||Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.|||Forms a heterodimer with PSMG1. http://togogenome.org/gene/9555:TIMM8B ^@ http://purl.uniprot.org/uniprot/A0A8I5N8Y1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9555:LMBR1L ^@ http://purl.uniprot.org/uniprot/A0A096MXF9 ^@ Similarity ^@ Belongs to the LIMR family. http://togogenome.org/gene/9555:INO80D ^@ http://purl.uniprot.org/uniprot/A0A096N2A6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:HIP1R ^@ http://purl.uniprot.org/uniprot/A0A096NBC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLA2 family.|||Membrane http://togogenome.org/gene/9555:CISD2 ^@ http://purl.uniprot.org/uniprot/A0A096NA12 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CISD protein family. CISD2 subfamily.|||Binds 1 [2Fe-2S] cluster.|||Endoplasmic reticulum membrane|||Homodimer.|||Mitochondrion outer membrane|||Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. http://togogenome.org/gene/9555:ANAPC5 ^@ http://purl.uniprot.org/uniprot/A0A096MPS8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APC5 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|||spindle http://togogenome.org/gene/9555:ENTR1 ^@ http://purl.uniprot.org/uniprot/A0A096NRS7|||http://purl.uniprot.org/uniprot/A0A2I3M5H6 ^@ Similarity ^@ Belongs to the ENTR1 family. http://togogenome.org/gene/9555:RPS29 ^@ http://purl.uniprot.org/uniprot/A0A096NE90 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Component of the 40S small ribosomal subunit. http://togogenome.org/gene/9555:HHATL ^@ http://purl.uniprot.org/uniprot/A0A096MZB3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:LOC101008118 ^@ http://purl.uniprot.org/uniprot/A9RA98 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:SSH3 ^@ http://purl.uniprot.org/uniprot/A0A096NC18 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. http://togogenome.org/gene/9555:LOC108586901 ^@ http://purl.uniprot.org/uniprot/A0A096N461 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/9555:ING4 ^@ http://purl.uniprot.org/uniprot/A0A096NS16 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9555:REM1 ^@ http://purl.uniprot.org/uniprot/A0A096NV11 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/9555:XIAP ^@ http://purl.uniprot.org/uniprot/A0A096NAP9 ^@ Similarity ^@ Belongs to the IAP family. http://togogenome.org/gene/9555:TNFRSF9 ^@ http://purl.uniprot.org/uniprot/A0A096N4S7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:TAS2R40 ^@ http://purl.uniprot.org/uniprot/A0A096N900 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9555:PRDM1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LS01|||http://purl.uniprot.org/uniprot/A0A8I5NJS0|||http://purl.uniprot.org/uniprot/A0A8I5QZ37 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily.|||Cytoplasm|||Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.|||Nucleus|||Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions. http://togogenome.org/gene/9555:PAIP2B ^@ http://purl.uniprot.org/uniprot/A0A2I3LPD0 ^@ Similarity ^@ Belongs to the PAIP2 family. http://togogenome.org/gene/9555:EPN2 ^@ http://purl.uniprot.org/uniprot/A0A096P342|||http://purl.uniprot.org/uniprot/A0A2I3LFW3 ^@ Similarity ^@ Belongs to the epsin family. http://togogenome.org/gene/9555:DAG1 ^@ http://purl.uniprot.org/uniprot/A0A096MT62 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.|||Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.|||cytoskeleton|||extracellular space|||nucleoplasm|||sarcolemma http://togogenome.org/gene/9555:STUM ^@ http://purl.uniprot.org/uniprot/A0A096NF61 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:PEX10 ^@ http://purl.uniprot.org/uniprot/A0A096N6G6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pex2/pex10/pex12 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9555:PABPC4 ^@ http://purl.uniprot.org/uniprot/A0A096NDE7|||http://purl.uniprot.org/uniprot/A0A2I3M327 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyadenylate-binding protein type-1 family.|||Binds the poly(A) tail of mRNA.|||Cytoplasm http://togogenome.org/gene/9555:RRP15 ^@ http://purl.uniprot.org/uniprot/A0A096N7V4 ^@ Similarity ^@ Belongs to the RRP15 family. http://togogenome.org/gene/9555:NKIRAS1 ^@ http://purl.uniprot.org/uniprot/A0A096MRJ4 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. http://togogenome.org/gene/9555:NAE1 ^@ http://purl.uniprot.org/uniprot/A0A096NJ91 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.|||Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. http://togogenome.org/gene/9555:LOC100997283 ^@ http://purl.uniprot.org/uniprot/A0A096N8H9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TOR1AIP family.|||Membrane http://togogenome.org/gene/9555:SPTSSB ^@ http://purl.uniprot.org/uniprot/A0A096NBI7 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:C1H1orf158 ^@ http://purl.uniprot.org/uniprot/A0A096MQ20 ^@ Function|||Subcellular Location Annotation ^@ Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.|||cilium axoneme http://togogenome.org/gene/9555:MPP3 ^@ http://purl.uniprot.org/uniprot/A0A096P5Y6 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/9555:CXXC1 ^@ http://purl.uniprot.org/uniprot/A0A096MLX7|||http://purl.uniprot.org/uniprot/A0A2I3M6U4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:NSFL1C ^@ http://purl.uniprot.org/uniprot/A0A096NV55|||http://purl.uniprot.org/uniprot/A0A2I3N819 ^@ Subcellular Location Annotation|||Subunit ^@ Golgi stack|||Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Binds ubiquitin and mono-ubiquitinated proteins via its N-terminal UBA-like domain when bound to VCP. http://togogenome.org/gene/9555:E2F7 ^@ http://purl.uniprot.org/uniprot/A0A2I3LK37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9555:GABRB1 ^@ http://purl.uniprot.org/uniprot/A0A096MTC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9555:PRKCI ^@ http://purl.uniprot.org/uniprot/A0A2I3M796|||http://purl.uniprot.org/uniprot/A0A2I3N5M9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cytoplasm http://togogenome.org/gene/9555:CBX7 ^@ http://purl.uniprot.org/uniprot/A0A096NK52 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:LUC7L3 ^@ http://purl.uniprot.org/uniprot/A0A096P4L3|||http://purl.uniprot.org/uniprot/A0A096P4L4 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/9555:DDX52 ^@ http://purl.uniprot.org/uniprot/A0A096P526 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily. http://togogenome.org/gene/9555:LOC101012199 ^@ http://purl.uniprot.org/uniprot/A0A8I5NC44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDCD10 family.|||Cell membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9555:MMP15 ^@ http://purl.uniprot.org/uniprot/A0A096NIY8 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9555:VASP ^@ http://purl.uniprot.org/uniprot/A0A0A0MWF4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Ena/VASP family.|||Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.|||cytoskeleton http://togogenome.org/gene/9555:GET3 ^@ http://purl.uniprot.org/uniprot/A0A0A0MVE0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.|||Belongs to the arsA ATPase family.|||Cytoplasm|||Endoplasmic reticulum|||Homodimer. Component of a transmembrane domain recognition complex (TRC). Interacts with SERP1 and SEC61B. Interacts with WRB.|||nucleolus http://togogenome.org/gene/9555:REXO4 ^@ http://purl.uniprot.org/uniprot/A0A096NRP1 ^@ Similarity ^@ Belongs to the REXO4 family. http://togogenome.org/gene/9555:SLC6A3 ^@ http://purl.uniprot.org/uniprot/A0A096MN61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily.|||Cell membrane|||Membrane|||axon|||neuron projection http://togogenome.org/gene/9555:PRDX2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LI37 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/9555:ETFA ^@ http://purl.uniprot.org/uniprot/A0A2I3MFF4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ETF alpha-subunit/FixB family.|||Binds 1 FAD per dimer.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion matrix|||The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). http://togogenome.org/gene/9555:FAM219B ^@ http://purl.uniprot.org/uniprot/A0A096NMS4 ^@ Similarity ^@ Belongs to the FAM219 family. http://togogenome.org/gene/9555:CACNB2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LJH8|||http://purl.uniprot.org/uniprot/A0A2I3LTW3|||http://purl.uniprot.org/uniprot/A0A2I3M014|||http://purl.uniprot.org/uniprot/A0A2I3MT39|||http://purl.uniprot.org/uniprot/A0A2I3MX69|||http://purl.uniprot.org/uniprot/A0A2I3N3W9|||http://purl.uniprot.org/uniprot/A0A2I3N3Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||sarcolemma http://togogenome.org/gene/9555:PSME3 ^@ http://purl.uniprot.org/uniprot/A0A2I3LD77 ^@ Similarity ^@ Belongs to the PA28 family. http://togogenome.org/gene/9555:MAPK1IP1L ^@ http://purl.uniprot.org/uniprot/A0A096NV73 ^@ Similarity ^@ Belongs to the MISS family. http://togogenome.org/gene/9555:MB ^@ http://purl.uniprot.org/uniprot/P68084 ^@ Function|||Similarity ^@ Belongs to the globin family.|||Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. http://togogenome.org/gene/9555:PBX4 ^@ http://purl.uniprot.org/uniprot/A0A0A0MVA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/PBX homeobox family.|||Nucleus http://togogenome.org/gene/9555:SH3BGRL ^@ http://purl.uniprot.org/uniprot/A0A096MME1 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/9555:DUSP3 ^@ http://purl.uniprot.org/uniprot/A0A096P164 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/9555:MTMR4 ^@ http://purl.uniprot.org/uniprot/A0A096P4U5|||http://purl.uniprot.org/uniprot/A0A8I5NJW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/9555:LOC101010008 ^@ http://purl.uniprot.org/uniprot/A0A096MRQ2 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9555:LIMK2 ^@ http://purl.uniprot.org/uniprot/A0A096NJM2|||http://purl.uniprot.org/uniprot/A0A2I3LEX5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. http://togogenome.org/gene/9555:ORMDL1 ^@ http://purl.uniprot.org/uniprot/A0A096NBS9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/9555:RSBN1 ^@ http://purl.uniprot.org/uniprot/A0A096N6J3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the round spermatid basic protein 1 family.|||Nucleus http://togogenome.org/gene/9555:SLC20A2 ^@ http://purl.uniprot.org/uniprot/A0A096NQS5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter. http://togogenome.org/gene/9555:NFE2 ^@ http://purl.uniprot.org/uniprot/A0A096NAN7 ^@ Similarity ^@ Belongs to the bZIP family. CNC subfamily. http://togogenome.org/gene/9555:ANXA9 ^@ http://purl.uniprot.org/uniprot/A0A096NYU9 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9555:NTHL1 ^@ http://purl.uniprot.org/uniprot/A0A096NL04 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nth/MutY family.|||Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.|||Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.|||Interacts with YBX1.|||Mitochondrion|||Nucleus http://togogenome.org/gene/9555:P4HA2 ^@ http://purl.uniprot.org/uniprot/A9CB24 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9555:FOXR1 ^@ http://purl.uniprot.org/uniprot/A0A096N8F6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:L3MBTL3 ^@ http://purl.uniprot.org/uniprot/A0A096P072|||http://purl.uniprot.org/uniprot/A0A2I3MKF6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:ZKSCAN7 ^@ http://purl.uniprot.org/uniprot/A0A096N786 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:ALG6 ^@ http://purl.uniprot.org/uniprot/A0A096NBF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG6/ALG8 glucosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:MFAP2 ^@ http://purl.uniprot.org/uniprot/A0A8I5P3U0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MFAP family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9555:OSGEPL1 ^@ http://purl.uniprot.org/uniprot/A0A096MX36 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 divalent metal cation per subunit.|||Mitochondrion|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. http://togogenome.org/gene/9555:DACT1 ^@ http://purl.uniprot.org/uniprot/A0A096NVE1 ^@ Similarity ^@ Belongs to the dapper family. http://togogenome.org/gene/9555:UGT2B15 ^@ http://purl.uniprot.org/uniprot/D2SML9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9555:CUZD1 ^@ http://purl.uniprot.org/uniprot/A0A096NU24 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:STX1A ^@ http://purl.uniprot.org/uniprot/A0A096MXE1 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9555:VGLL2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LPL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vestigial family.|||Nucleus http://togogenome.org/gene/9555:UGT3A2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LVM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9555:FAM91A1 ^@ http://purl.uniprot.org/uniprot/A0A096NWC4 ^@ Similarity ^@ Belongs to the FAM91 family. http://togogenome.org/gene/9555:SET ^@ http://purl.uniprot.org/uniprot/A0A2I3MTM8 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9555:ING5 ^@ http://purl.uniprot.org/uniprot/A0A096MY69 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9555:LSM7 ^@ http://purl.uniprot.org/uniprot/A0A8I5N5R5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus http://togogenome.org/gene/9555:MDM1 ^@ http://purl.uniprot.org/uniprot/A0A096MWR7|||http://purl.uniprot.org/uniprot/A0A8I5NFD3|||http://purl.uniprot.org/uniprot/A0A8I5P433 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM1 family.|||Nucleus|||centriole http://togogenome.org/gene/9555:CEBPE ^@ http://purl.uniprot.org/uniprot/A0A2I3NEK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. C/EBP subfamily.|||Nucleus http://togogenome.org/gene/9555:BPGM ^@ http://purl.uniprot.org/uniprot/A0A096NFF1 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/9555:LOC108585455 ^@ http://purl.uniprot.org/uniprot/A0A2I3LZH6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIIc family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:CLK4 ^@ http://purl.uniprot.org/uniprot/A0A096NDY0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:MAPK3 ^@ http://purl.uniprot.org/uniprot/A0A096NHR1|||http://purl.uniprot.org/uniprot/A0A2I3MRY2 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.|||caveola|||focal adhesion http://togogenome.org/gene/9555:PSMB10 ^@ http://purl.uniprot.org/uniprot/A0A096NY91 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:FOXH1 ^@ http://purl.uniprot.org/uniprot/A0A096MX72 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:POLR3K ^@ http://purl.uniprot.org/uniprot/A9L8T4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/9555:LOC101015199 ^@ http://purl.uniprot.org/uniprot/A0A8I5N396 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:SNX9 ^@ http://purl.uniprot.org/uniprot/A0A2I3LJQ9|||http://purl.uniprot.org/uniprot/A0A2I3LVG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane http://togogenome.org/gene/9555:SLC22A4 ^@ http://purl.uniprot.org/uniprot/A9CB25 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by intracellular ATP.|||Apical cell membrane|||Basal cell membrane|||Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.|||Interacts with PDZK1.|||Mitochondrion membrane|||Transporter that mediates the transport of endogenous and microbial zwitterions and organic cations. Functions as a Na(+)-dependent and pH-dependent high affinity microbial symporter of potent food-derived antioxidant ergothioeine (By similarity). Transports one sodium ion with one ergothioeine molecule (By similarity). Involved in the absorption of ergothioneine from the luminal/apical side of the small intestine and renal tubular cells, and into non-parenchymal liver cells, thereby contributing to maintain steady-state ergothioneine level in the body. Also mediates the bidirectional transport of acetycholine, although the exact transport mechanism has not been fully identified yet. Most likely exports anti-inflammatory acetylcholine in non-neuronal tissues, thereby contributing to the non-neuronal cholinergic system. Displays a general physiological role linked to better survival by controlling inflammation and oxidative stress, which may be related to ergothioneine and acetycholine transports. May also function as a low-affinity Na(+)-dependent transporter of L-carnitine through the mitochondrial membrane, thereby maintaining intracellular carnitine homeostasis. May contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (By similarity). http://togogenome.org/gene/9555:PSMA2 ^@ http://purl.uniprot.org/uniprot/A0A096MXE0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9555:TMEM237 ^@ http://purl.uniprot.org/uniprot/A0A096NQC0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM237 family.|||Component of the transition zone in primary cilia. Required for ciliogenesis.|||Membrane|||cilium http://togogenome.org/gene/9555:INTS14 ^@ http://purl.uniprot.org/uniprot/A0A096NME1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INTS14 family.|||Nucleus|||Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. http://togogenome.org/gene/9555:TRIM14 ^@ http://purl.uniprot.org/uniprot/A0A096P128 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9555:MRPS24 ^@ http://purl.uniprot.org/uniprot/A0A096NZN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS3 family.|||Mitochondrion http://togogenome.org/gene/9555:DRAM1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NN73 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:LPAR4 ^@ http://purl.uniprot.org/uniprot/A0A096MLK8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9555:UBE2I ^@ http://purl.uniprot.org/uniprot/A0A2I3M9Y2 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9555:TMBIM1 ^@ http://purl.uniprot.org/uniprot/A0A096MRK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9555:TMEM258 ^@ http://purl.uniprot.org/uniprot/A0A096MQE1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST5 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/9555:IRF6 ^@ http://purl.uniprot.org/uniprot/A0A2I3M1A6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:IGFL3 ^@ http://purl.uniprot.org/uniprot/A0A096MKZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IGFL family.|||Secreted http://togogenome.org/gene/9555:DIPK1B ^@ http://purl.uniprot.org/uniprot/A0A8I5NNP2 ^@ Similarity ^@ Belongs to the DIPK family. http://togogenome.org/gene/9555:PCNA ^@ http://purl.uniprot.org/uniprot/A0A096NVE2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PCNA family.|||Nucleus|||This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. http://togogenome.org/gene/9555:GDF2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LGS2 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9555:C8H8orf82 ^@ http://purl.uniprot.org/uniprot/A0A096N203 ^@ Similarity ^@ Belongs to the UPF0598 family. http://togogenome.org/gene/9555:SLC25A11 ^@ http://purl.uniprot.org/uniprot/A0A096P2I5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9555:NPM3 ^@ http://purl.uniprot.org/uniprot/A0A096P6C6 ^@ Similarity ^@ Belongs to the nucleoplasmin family. http://togogenome.org/gene/9555:LOC101026757 ^@ http://purl.uniprot.org/uniprot/A0A2I3M4Z1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9555:CRHR1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LHP9|||http://purl.uniprot.org/uniprot/A0A2I3MWY0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.|||Membrane http://togogenome.org/gene/9555:CHPF2 ^@ http://purl.uniprot.org/uniprot/A0A096NFE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9555:TRIP13 ^@ http://purl.uniprot.org/uniprot/A0A096NC09 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AAA ATPase family. PCH2 subfamily.|||Nucleus|||Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways.|||Specifically interacts with the ligand binding domain of the thyroid receptor (TR). This interaction does not require the presence of thyroid hormone for its interaction. Interacts with proteasome subunit PSMA8; to participate in meiosis progression during spermatogenesis. http://togogenome.org/gene/9555:LOC101016903 ^@ http://purl.uniprot.org/uniprot/A0A096MZA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/9555:EIF4ENIF1 ^@ http://purl.uniprot.org/uniprot/A9CB33 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:ACBD5 ^@ http://purl.uniprot.org/uniprot/A0A096P3V3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.|||Belongs to the ATG37 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9555:EIF3K ^@ http://purl.uniprot.org/uniprot/A0A0A0MUQ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit K family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with CCND3, but not with CCND1 and CCND2.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:KRT19 ^@ http://purl.uniprot.org/uniprot/A0A2I3MA29 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9555:LOC101008727 ^@ http://purl.uniprot.org/uniprot/A0A096MRQ2 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9555:LOC101001292 ^@ http://purl.uniprot.org/uniprot/A0A0A0MXJ9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9555:LOC101018881 ^@ http://purl.uniprot.org/uniprot/A0A096NZT3 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9555:DIMT1 ^@ http://purl.uniprot.org/uniprot/A0A096MMS8 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. http://togogenome.org/gene/9555:OLFR600 ^@ http://purl.uniprot.org/uniprot/A9L8X1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:SCGB2A2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MIK8 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9555:TMEM86A ^@ http://purl.uniprot.org/uniprot/A0A8I5NJ16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM86 family.|||Membrane http://togogenome.org/gene/9555:NT5C2 ^@ http://purl.uniprot.org/uniprot/A0A096P6G6|||http://purl.uniprot.org/uniprot/A0A2I3M8B9 ^@ Cofactor|||Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/9555:ATP23 ^@ http://purl.uniprot.org/uniprot/A0A2I3LE10 ^@ Similarity ^@ Belongs to the peptidase M76 family. http://togogenome.org/gene/9555:RRAD ^@ http://purl.uniprot.org/uniprot/A0A096NJA0 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/9555:ATL3 ^@ http://purl.uniprot.org/uniprot/A0A2I3MEQ1 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9555:SMPDL3A ^@ http://purl.uniprot.org/uniprot/A0A096NGH5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acid sphingomyelinase family.|||Binds 2 Zn(2+) per subunit.|||Secreted http://togogenome.org/gene/9555:AMZ1 ^@ http://purl.uniprot.org/uniprot/A0A096NQ88 ^@ Function|||Similarity ^@ Belongs to the peptidase M54 family.|||Probable zinc metalloprotease. http://togogenome.org/gene/9555:XKR9 ^@ http://purl.uniprot.org/uniprot/A0A8I5NTC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9555:SIX5 ^@ http://purl.uniprot.org/uniprot/A0A0A0MXG2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:RAP2C ^@ http://purl.uniprot.org/uniprot/A0A2I3MSQ5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Palmitoylated.|||Recycling endosome membrane|||Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. http://togogenome.org/gene/9555:HPGD ^@ http://purl.uniprot.org/uniprot/A0A096N864 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9555:THRAP3 ^@ http://purl.uniprot.org/uniprot/A0A8I5NAV3 ^@ Similarity ^@ Belongs to the BCLAF1/THRAP3 family. http://togogenome.org/gene/9555:MCTS1 ^@ http://purl.uniprot.org/uniprot/A0A096N4X2|||http://purl.uniprot.org/uniprot/A0A2I3MNA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCTS1 family.|||Cytoplasm http://togogenome.org/gene/9555:LOC101003865 ^@ http://purl.uniprot.org/uniprot/A0A096MM42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:NIT1 ^@ http://purl.uniprot.org/uniprot/A0A2I3NBE5 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. http://togogenome.org/gene/9555:GRAMD1B ^@ http://purl.uniprot.org/uniprot/A0A2I3MEC8|||http://purl.uniprot.org/uniprot/A0A2I3N9U2 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:ACOD1 ^@ http://purl.uniprot.org/uniprot/A0A096MSC9 ^@ Similarity ^@ Belongs to the PrpD family. http://togogenome.org/gene/9555:TMSB15A ^@ http://purl.uniprot.org/uniprot/A0A2I3N094 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/9555:PM20D2 ^@ http://purl.uniprot.org/uniprot/A0A096P097 ^@ Function|||Similarity ^@ Belongs to the peptidase M20A family.|||Catalyzes the peptide bond hydrolysis in dipeptides having basic amino acids lysine, ornithine or arginine at C-terminus. http://togogenome.org/gene/9555:LOC103879435 ^@ http://purl.uniprot.org/uniprot/A0A2I3MU01 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS26 family. http://togogenome.org/gene/9555:ELAVL2 ^@ http://purl.uniprot.org/uniprot/A0A2I3M4M7|||http://purl.uniprot.org/uniprot/A0A2I3MKW7 ^@ Similarity ^@ Belongs to the RRM elav family. http://togogenome.org/gene/9555:ASPDH ^@ http://purl.uniprot.org/uniprot/A0A0A0MWW7|||http://purl.uniprot.org/uniprot/A0A8I5NW29 ^@ Similarity ^@ Belongs to the L-aspartate dehydrogenase family. http://togogenome.org/gene/9555:PDE6C ^@ http://purl.uniprot.org/uniprot/A0A096P5N5 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9555:PFDN5 ^@ http://purl.uniprot.org/uniprot/A0A096N1G6 ^@ Similarity ^@ Belongs to the prefoldin subunit alpha family. http://togogenome.org/gene/9555:CFAP298 ^@ http://purl.uniprot.org/uniprot/A9CAY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP298 family.|||cilium basal body http://togogenome.org/gene/9555:NDUFAB1 ^@ http://purl.uniprot.org/uniprot/A0A096NHF4 ^@ Function|||Similarity ^@ Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis. http://togogenome.org/gene/9555:FAM20B ^@ http://purl.uniprot.org/uniprot/A0A096MNQ0 ^@ Similarity ^@ Belongs to the FAM20 family. http://togogenome.org/gene/9555:BHLHB9 ^@ http://purl.uniprot.org/uniprot/A0A096NW89 ^@ Similarity ^@ Belongs to the GPRASP family. http://togogenome.org/gene/9555:CCR10 ^@ http://purl.uniprot.org/uniprot/A0A096P5U6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9555:PON3 ^@ http://purl.uniprot.org/uniprot/A0A2I3NG76 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit.|||Glycosylated. http://togogenome.org/gene/9555:GASK1B ^@ http://purl.uniprot.org/uniprot/A0A096MZJ2 ^@ Similarity ^@ Belongs to the GASK family. http://togogenome.org/gene/9555:MAGT1 ^@ http://purl.uniprot.org/uniprot/A0A096NC61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:GADD45A ^@ http://purl.uniprot.org/uniprot/A0A096N8C4 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/9555:ARL8A ^@ http://purl.uniprot.org/uniprot/A0A096NPR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||axon|||spindle http://togogenome.org/gene/9555:TFB2M ^@ http://purl.uniprot.org/uniprot/A0A8I5R6P9 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:LOC101023761 ^@ http://purl.uniprot.org/uniprot/A0A2I3M1L7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COA8 family.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:BAIAP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MBC3 ^@ Function|||Subcellular Location Annotation ^@ Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.|||Membrane|||cytoskeleton|||filopodium|||ruffle http://togogenome.org/gene/9555:TFR2 ^@ http://purl.uniprot.org/uniprot/A0A096NRN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:CD37 ^@ http://purl.uniprot.org/uniprot/A0A2I3MBN9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:DPM2 ^@ http://purl.uniprot.org/uniprot/A0A096P1Z0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPM2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum membrane|||Membrane|||Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. http://togogenome.org/gene/9555:AADACL4 ^@ http://purl.uniprot.org/uniprot/A0A096MNX0 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/9555:BEX5 ^@ http://purl.uniprot.org/uniprot/A0A8I5NWU6 ^@ Similarity ^@ Belongs to the BEX family. http://togogenome.org/gene/9555:NPRL2 ^@ http://purl.uniprot.org/uniprot/A0A096N0N9 ^@ Similarity ^@ Belongs to the NPR2 family. http://togogenome.org/gene/9555:RPS26 ^@ http://purl.uniprot.org/uniprot/A0A2I3MBA7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS26 family. http://togogenome.org/gene/9555:RRP1B ^@ http://purl.uniprot.org/uniprot/A0A8I5MY62 ^@ Similarity ^@ Belongs to the RRP1 family. http://togogenome.org/gene/9555:LRP8 ^@ http://purl.uniprot.org/uniprot/A0A096MX29|||http://purl.uniprot.org/uniprot/A0A2I3MBU8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:KIF5A ^@ http://purl.uniprot.org/uniprot/A0A2I3ML31 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9555:TUFM ^@ http://purl.uniprot.org/uniprot/A0A096NHN3 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/9555:ETFB ^@ http://purl.uniprot.org/uniprot/A0A0A0MWL3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ETF beta-subunit/FixA family.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion matrix|||The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). http://togogenome.org/gene/9555:CDH11 ^@ http://purl.uniprot.org/uniprot/A0A096NJ47 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:SLC16A1 ^@ http://purl.uniprot.org/uniprot/A0A096MSZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/9555:CD14 ^@ http://purl.uniprot.org/uniprot/A0A096MKV9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Interacts with LPAR1.|||Cell membrane|||Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).|||Golgi apparatus|||Membrane raft|||Secreted http://togogenome.org/gene/9555:IL1RAPL1 ^@ http://purl.uniprot.org/uniprot/A0A096N6P1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the interleukin-1 receptor family.|||axon|||dendrite http://togogenome.org/gene/9555:RFX1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MNT5|||http://purl.uniprot.org/uniprot/A0A8I5NIP2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:ATG9A ^@ http://purl.uniprot.org/uniprot/A0A096NPP6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.|||Preautophagosomal structure membrane http://togogenome.org/gene/9555:SLC39A11 ^@ http://purl.uniprot.org/uniprot/A0A096NU49 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:CDK10 ^@ http://purl.uniprot.org/uniprot/A0A096MNE3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:PPP2R2B ^@ http://purl.uniprot.org/uniprot/A0A096N2J9|||http://purl.uniprot.org/uniprot/A0A096NZC5|||http://purl.uniprot.org/uniprot/A0A2I3LND1|||http://purl.uniprot.org/uniprot/A0A2I3MJR1|||http://purl.uniprot.org/uniprot/A0A2I3MKS1 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/9555:NT5DC2 ^@ http://purl.uniprot.org/uniprot/A0A096MZG9|||http://purl.uniprot.org/uniprot/A0A2I3LQT3 ^@ Cofactor|||Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/9555:LHX2 ^@ http://purl.uniprot.org/uniprot/A0A096P0M4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:NFX1 ^@ http://purl.uniprot.org/uniprot/A0A096P1C5|||http://purl.uniprot.org/uniprot/A0A2I3LZC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NFX1 family.|||Nucleus http://togogenome.org/gene/9555:GTF2H3 ^@ http://purl.uniprot.org/uniprot/A0A2I3NDJ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB4 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.|||Nucleus|||Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7. http://togogenome.org/gene/9555:SLC34A2 ^@ http://purl.uniprot.org/uniprot/A0A8I5N544 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the SLC34A transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:ILKAP ^@ http://purl.uniprot.org/uniprot/A0A096N532 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9555:USP7 ^@ http://purl.uniprot.org/uniprot/A0A2I3LZT9|||http://purl.uniprot.org/uniprot/A0A2I3MYJ1 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/9555:SSTR3 ^@ http://purl.uniprot.org/uniprot/A0A096NJW0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9555:UCK2 ^@ http://purl.uniprot.org/uniprot/A0A8I5R0V9 ^@ Similarity ^@ Belongs to the uridine kinase family. http://togogenome.org/gene/9555:XKR5 ^@ http://purl.uniprot.org/uniprot/A0A096N423 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9555:FIGN ^@ http://purl.uniprot.org/uniprot/A0A2I3LNL5 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9555:ASB9 ^@ http://purl.uniprot.org/uniprot/A0A096N1A4 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9555:MYADM ^@ http://purl.uniprot.org/uniprot/A0A0A0MVT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAL family.|||Membrane http://togogenome.org/gene/9555:LSM4 ^@ http://purl.uniprot.org/uniprot/A0A0A0MUH5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/9555:RPS7 ^@ http://purl.uniprot.org/uniprot/A0A096N4U1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eS7 family.|||centrosome http://togogenome.org/gene/9555:CDC25A ^@ http://purl.uniprot.org/uniprot/A0A096N005|||http://purl.uniprot.org/uniprot/A0A096NEQ7 ^@ Function|||Similarity ^@ Belongs to the MPI phosphatase family.|||Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. http://togogenome.org/gene/9555:PPA1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NK25 ^@ Similarity ^@ Belongs to the PPase family. http://togogenome.org/gene/9555:TP53INP2 ^@ http://purl.uniprot.org/uniprot/A0A096NUS2 ^@ Subcellular Location Annotation ^@ PML body|||autophagosome|||cytosol http://togogenome.org/gene/9555:VIP ^@ http://purl.uniprot.org/uniprot/A0A096MV91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/9555:HMGN1 ^@ http://purl.uniprot.org/uniprot/B0CM34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/9555:B3GLCT ^@ http://purl.uniprot.org/uniprot/A0A2I3MN33|||http://purl.uniprot.org/uniprot/A0A2I3NBZ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:HINT2 ^@ http://purl.uniprot.org/uniprot/A0A096P167 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/9555:HOMER3 ^@ http://purl.uniprot.org/uniprot/A0A0A0MU79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Homer family.|||Cytoplasm|||Postsynaptic density|||Synapse http://togogenome.org/gene/9555:RPLP0 ^@ http://purl.uniprot.org/uniprot/A0A2I3MMC5 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL10 family.|||Ribosomal protein P0 is the functional equivalent of E.coli protein L10. http://togogenome.org/gene/9555:OSMR ^@ http://purl.uniprot.org/uniprot/A0A096NBN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/9555:MEIS2 ^@ http://purl.uniprot.org/uniprot/A0A2I3N0R6|||http://purl.uniprot.org/uniprot/A0A2I3N8K9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/9555:HMGB2 ^@ http://purl.uniprot.org/uniprot/A0A096MR30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/9555:SLC2A5 ^@ http://purl.uniprot.org/uniprot/A0A096N791 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Cell membrane|||Membrane|||sarcolemma http://togogenome.org/gene/9555:KCNS3 ^@ http://purl.uniprot.org/uniprot/A0A096NP34 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9555:PARP11 ^@ http://purl.uniprot.org/uniprot/A0A096NEC0|||http://purl.uniprot.org/uniprot/A0A2I3LSH3 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9555:UBE2N ^@ http://purl.uniprot.org/uniprot/A0A8I5MW31 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9555:GALR2 ^@ http://purl.uniprot.org/uniprot/A0A096NT18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9555:IL7 ^@ http://purl.uniprot.org/uniprot/A0A096N2Z5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-7/IL-9 family.|||Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis.|||Secreted http://togogenome.org/gene/9555:HBD ^@ http://purl.uniprot.org/uniprot/A9L8X8 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9555:RTN3 ^@ http://purl.uniprot.org/uniprot/A0A2I3LKE8 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:RRAGC ^@ http://purl.uniprot.org/uniprot/A0A096MR41 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/9555:SLC25A24 ^@ http://purl.uniprot.org/uniprot/A0A096MPG5|||http://purl.uniprot.org/uniprot/A0A2I3MB09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:C5AR1 ^@ http://purl.uniprot.org/uniprot/A0A2I3M3B2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:TRIAP1 ^@ http://purl.uniprot.org/uniprot/A0A096NDD4 ^@ Similarity ^@ Belongs to the TRIAP1/MDM35 family. http://togogenome.org/gene/9555:SLC10A1 ^@ http://purl.uniprot.org/uniprot/A0A096NVU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/9555:ND5 ^@ http://purl.uniprot.org/uniprot/K9MVJ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 5 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:ALKBH1 ^@ http://purl.uniprot.org/uniprot/A0A096NSA1 ^@ Cofactor|||Similarity ^@ Belongs to the alkB family.|||Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/9555:LOC101007158 ^@ http://purl.uniprot.org/uniprot/A0A2I3LS09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MUSTANG family.|||Nucleus http://togogenome.org/gene/9555:THRB ^@ http://purl.uniprot.org/uniprot/A0A096NYA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9555:IMPA2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NPC3 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/9555:TNS4 ^@ http://purl.uniprot.org/uniprot/A0A096P5H3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTEN phosphatase protein family.|||focal adhesion http://togogenome.org/gene/9555:CLTA ^@ http://purl.uniprot.org/uniprot/A0A096P160|||http://purl.uniprot.org/uniprot/A0A2I3MAW0|||http://purl.uniprot.org/uniprot/A0A2I3MV58|||http://purl.uniprot.org/uniprot/A0A2I3NBR3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin light chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||coated pit http://togogenome.org/gene/9555:HYAL2 ^@ http://purl.uniprot.org/uniprot/A0A096N541 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/9555:NR1H3 ^@ http://purl.uniprot.org/uniprot/A0A096NGD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9555:VPS26A ^@ http://purl.uniprot.org/uniprot/A0A096P4Z9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS26 family.|||Endosome http://togogenome.org/gene/9555:SH3BGR ^@ http://purl.uniprot.org/uniprot/A0A8I5P0F4 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/9555:NUP35 ^@ http://purl.uniprot.org/uniprot/A0A096NFU8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Nup35 family.|||Functions as a component of the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/9555:F3 ^@ http://purl.uniprot.org/uniprot/A0A096MM85|||http://purl.uniprot.org/uniprot/A0A2I3LSJ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tissue factor family.|||Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.|||Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.|||Membrane http://togogenome.org/gene/9555:FSCN3 ^@ http://purl.uniprot.org/uniprot/A9RA80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fascin family.|||cytoskeleton http://togogenome.org/gene/9555:MIGA2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YJB9|||http://purl.uniprot.org/uniprot/B0CM94 ^@ Similarity ^@ Belongs to the mitoguardin family. http://togogenome.org/gene/9555:VPS72 ^@ http://purl.uniprot.org/uniprot/A9X196 ^@ Function|||Similarity ^@ Belongs to the VPS72/YL1 family.|||Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. http://togogenome.org/gene/9555:STARD5 ^@ http://purl.uniprot.org/uniprot/A0A096NMZ1 ^@ Function ^@ May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols. http://togogenome.org/gene/9555:SERPINB10 ^@ http://purl.uniprot.org/uniprot/A0A096ML06|||http://purl.uniprot.org/uniprot/A9RA96 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the serpin family.|||Belongs to the serpin family. Ov-serpin subfamily.|||Cytoplasm|||Nucleus|||Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus (By similarity). http://togogenome.org/gene/9555:AP2A1 ^@ http://purl.uniprot.org/uniprot/A0A0A0MUL4|||http://purl.uniprot.org/uniprot/A0A2I3LTA7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).|||Belongs to the adaptor complexes large subunit family.|||Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.|||coated pit http://togogenome.org/gene/9555:LOC101015786 ^@ http://purl.uniprot.org/uniprot/A0A096NGN6 ^@ Similarity|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/9555:CA2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LHY3 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9555:JUNB ^@ http://purl.uniprot.org/uniprot/A0A0A0MUL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. Jun subfamily.|||Nucleus http://togogenome.org/gene/9555:LOC101009903 ^@ http://purl.uniprot.org/uniprot/A0A096NG11 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9555:OPALIN ^@ http://purl.uniprot.org/uniprot/A0A8I5NAC4|||http://purl.uniprot.org/uniprot/A0A8I5NK05 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation.|||Membrane http://togogenome.org/gene/9555:PEX7 ^@ http://purl.uniprot.org/uniprot/A0A8I5MX76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat peroxin-7 family.|||Peroxisome matrix|||cytosol http://togogenome.org/gene/9555:PTK6 ^@ http://purl.uniprot.org/uniprot/A0A096NN61 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9555:PRDX6 ^@ http://purl.uniprot.org/uniprot/A0A096NR25 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/9555:GRB14 ^@ http://purl.uniprot.org/uniprot/A0A096MTV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRB7/10/14 family.|||Cytoplasm http://togogenome.org/gene/9555:POLB ^@ http://purl.uniprot.org/uniprot/A0A096N1P6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||Cytoplasm|||DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.|||Nucleus http://togogenome.org/gene/9555:PPP1R21 ^@ http://purl.uniprot.org/uniprot/A0A096MS74|||http://purl.uniprot.org/uniprot/A0A2I3LUG0|||http://purl.uniprot.org/uniprot/A0A2I3N5Q8 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9555:ENKD1 ^@ http://purl.uniprot.org/uniprot/A0A096NQ98 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9555:CMC4 ^@ http://purl.uniprot.org/uniprot/A0A096ML73 ^@ Similarity ^@ Belongs to the CMC4 family. http://togogenome.org/gene/9555:CCDC126 ^@ http://purl.uniprot.org/uniprot/A0A096MSH8 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9555:CPA6 ^@ http://purl.uniprot.org/uniprot/A0A096MUH1 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9555:CDNF ^@ http://purl.uniprot.org/uniprot/A0A096P3H8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARMET family.|||Secreted http://togogenome.org/gene/9555:PREPL ^@ http://purl.uniprot.org/uniprot/A0A096N3M7 ^@ Similarity ^@ Belongs to the peptidase S9A family. http://togogenome.org/gene/9555:ADCK5 ^@ http://purl.uniprot.org/uniprot/A0A096ND93 ^@ Similarity ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family. http://togogenome.org/gene/9555:ACTL7B ^@ http://purl.uniprot.org/uniprot/A0A096NEI2 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9555:AIFM1 ^@ http://purl.uniprot.org/uniprot/A0A096MPH0|||http://purl.uniprot.org/uniprot/A0A2I3NAA8 ^@ Similarity ^@ Belongs to the FAD-dependent oxidoreductase family. http://togogenome.org/gene/9555:SPSB4 ^@ http://purl.uniprot.org/uniprot/A0A096MWB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPSB family.|||Cytoplasm http://togogenome.org/gene/9555:TBX19 ^@ http://purl.uniprot.org/uniprot/A0A096N9R7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9555:CLIC4 ^@ http://purl.uniprot.org/uniprot/A0A096NDH5 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/9555:TOB2 ^@ http://purl.uniprot.org/uniprot/A0A096NRU5 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9555:LCAT ^@ http://purl.uniprot.org/uniprot/Q08758 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ APOA1 is the most potent activator in plasma. Also activated by APOE, APOC1 and APOA4 (By similarity).|||Belongs to the AB hydrolase superfamily. Lipase family.|||Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (By similarity).|||Most abundant in liver and cerebellum.|||Secreted http://togogenome.org/gene/9555:GATAD1 ^@ http://purl.uniprot.org/uniprot/A0A096MZM5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:HEXIM2 ^@ http://purl.uniprot.org/uniprot/A0A096P656 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HEXIM family.|||Nucleus http://togogenome.org/gene/9555:TRPC3 ^@ http://purl.uniprot.org/uniprot/A0A2I3N089 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:BEST2 ^@ http://purl.uniprot.org/uniprot/A0A0A0MV62 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms calcium-sensitive chloride channels. Permeable to bicarbonate.|||Membrane http://togogenome.org/gene/9555:HMGCS2 ^@ http://purl.uniprot.org/uniprot/A0A096N5K0 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family.|||Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. http://togogenome.org/gene/9555:NKAP ^@ http://purl.uniprot.org/uniprot/A0A096NP52 ^@ Similarity ^@ Belongs to the NKAP family. http://togogenome.org/gene/9555:TGFB2 ^@ http://purl.uniprot.org/uniprot/A0A096ML01|||http://purl.uniprot.org/uniprot/A0A096MY44 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.|||extracellular matrix http://togogenome.org/gene/9555:RCAN1 ^@ http://purl.uniprot.org/uniprot/A0A2I3N813|||http://purl.uniprot.org/uniprot/A0A8I5N4B4 ^@ Similarity ^@ Belongs to the RCAN family. http://togogenome.org/gene/9555:LOC101009649 ^@ http://purl.uniprot.org/uniprot/A0A096NT75 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.|||Belongs to the 7B2 family.|||Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.|||Secreted http://togogenome.org/gene/9555:HAPLN2 ^@ http://purl.uniprot.org/uniprot/A0A096MRW4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:PDYN ^@ http://purl.uniprot.org/uniprot/A0A096NV66 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the opioid neuropeptide precursor family.|||Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin.|||Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.|||Leumorphin has a typical opioid activity and may have anti-apoptotic effect.|||Secreted http://togogenome.org/gene/9555:TM2D2 ^@ http://purl.uniprot.org/uniprot/A0A2I3N587 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:BMP10 ^@ http://purl.uniprot.org/uniprot/A0A8I5N5C9 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9555:MAL ^@ http://purl.uniprot.org/uniprot/A0A8I5NLH4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:FXYD3 ^@ http://purl.uniprot.org/uniprot/A0A0A0MXG6 ^@ Caution|||Similarity ^@ Belongs to the FXYD family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:TCTA ^@ http://purl.uniprot.org/uniprot/A0A096N2N4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TCTA family.|||May be required for cellular fusion during osteoclastogenesis.|||Membrane http://togogenome.org/gene/9555:LOC100997213 ^@ http://purl.uniprot.org/uniprot/A0A096P2V0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/9555:CYSTM1 ^@ http://purl.uniprot.org/uniprot/A0A096MLP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYSTM1 family.|||Membrane http://togogenome.org/gene/9555:CRYL1 ^@ http://purl.uniprot.org/uniprot/A0A096NP27 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/9555:TMEM198 ^@ http://purl.uniprot.org/uniprot/B0CM55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM198 family.|||Membrane http://togogenome.org/gene/9555:ORMDL2 ^@ http://purl.uniprot.org/uniprot/A0A096P5D6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/9555:SNRPE ^@ http://purl.uniprot.org/uniprot/A0A2I3LPQ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing.|||cytosol http://togogenome.org/gene/9555:HOPX ^@ http://purl.uniprot.org/uniprot/A0A8I5R6B8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:RGS7BP ^@ http://purl.uniprot.org/uniprot/A0A096MN36 ^@ Similarity ^@ Belongs to the RGS7BP/RGS9BP family. http://togogenome.org/gene/9555:SYNJ2 ^@ http://purl.uniprot.org/uniprot/A0A096NWZ4 ^@ Similarity ^@ Belongs to the synaptojanin family.|||In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family. http://togogenome.org/gene/9555:VPS51 ^@ http://purl.uniprot.org/uniprot/A0A096N0J4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VPS51 family.|||Component of the Golgi-associated retrograde protein (GARP) complex. Component of the endosome-associated retrograde protein (EARP) complex.|||Endosome|||Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling.|||Recycling endosome|||trans-Golgi network http://togogenome.org/gene/9555:TMED2 ^@ http://purl.uniprot.org/uniprot/A0A096NBB9|||http://purl.uniprot.org/uniprot/A0A2I3LEI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9555:PKIA ^@ http://purl.uniprot.org/uniprot/A0A096NEX9 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/9555:RGS4 ^@ http://purl.uniprot.org/uniprot/A0A096MRL1 ^@ Function ^@ Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. http://togogenome.org/gene/9555:RPS6KA4 ^@ http://purl.uniprot.org/uniprot/A0A096NBN9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9555:EIF3I ^@ http://purl.uniprot.org/uniprot/A0A096NFN8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit I family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm|||Phosphorylated by TGF-beta type II receptor. http://togogenome.org/gene/9555:LYPLA2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NUP5 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/9555:COR51P3 ^@ http://purl.uniprot.org/uniprot/A9L8W6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:SNPH ^@ http://purl.uniprot.org/uniprot/A0A096NV48 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:STX3 ^@ http://purl.uniprot.org/uniprot/A0A2I3LUE6|||http://purl.uniprot.org/uniprot/A0A2I3M9I6|||http://purl.uniprot.org/uniprot/A0A2I3MNQ4 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9555:HOXB9 ^@ http://purl.uniprot.org/uniprot/A0A096P431 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/9555:SLC37A4 ^@ http://purl.uniprot.org/uniprot/A0A096NCP1|||http://purl.uniprot.org/uniprot/A0A2I3MDT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Membrane http://togogenome.org/gene/9555:KAT7 ^@ http://purl.uniprot.org/uniprot/A0A2I3MF63|||http://purl.uniprot.org/uniprot/A0A8I5NLF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/9555:APOA1 ^@ http://purl.uniprot.org/uniprot/A0A0B4J2H6 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/9555:NMUR1 ^@ http://purl.uniprot.org/uniprot/A0A2I3M558 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for the neuromedin-U and neuromedin-S neuropeptides. http://togogenome.org/gene/9555:SLITRK6 ^@ http://purl.uniprot.org/uniprot/A0A096NCU7 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9555:TNNT3 ^@ http://purl.uniprot.org/uniprot/A9L953 ^@ Function|||Similarity ^@ Belongs to the troponin T family.|||Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. http://togogenome.org/gene/9555:INPP1 ^@ http://purl.uniprot.org/uniprot/A0A096NMQ4 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/9555:HS6ST2 ^@ http://purl.uniprot.org/uniprot/A0A096MMZ8|||http://purl.uniprot.org/uniprot/A0A096N7C7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.|||Belongs to the sulfotransferase 6 family.|||Membrane http://togogenome.org/gene/9555:SLC35F1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NM57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/9555:PPARD ^@ http://purl.uniprot.org/uniprot/A0A096NHN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9555:FCHO2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LI71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FCHO family.|||clathrin-coated pit http://togogenome.org/gene/9555:CFTR ^@ http://purl.uniprot.org/uniprot/A0A2I3MLR3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.|||Cell membrane|||Early endosome membrane|||Endoplasmic reticulum membrane|||Endosome membrane|||Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.|||Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.|||Membrane|||Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and NHERF1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through NHERF1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation.|||Recycling endosome membrane http://togogenome.org/gene/9555:PAM16 ^@ http://purl.uniprot.org/uniprot/A0A2I3MZ09 ^@ Similarity ^@ Belongs to the TIM16/PAM16 family. http://togogenome.org/gene/9555:YWHAG ^@ http://purl.uniprot.org/uniprot/A0A096NJN7 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9555:S100A10 ^@ http://purl.uniprot.org/uniprot/A0A2I3LUR9 ^@ Function ^@ Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. http://togogenome.org/gene/9555:GDPD5 ^@ http://purl.uniprot.org/uniprot/A0A096N1J2 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9555:ITIH1 ^@ http://purl.uniprot.org/uniprot/A0A096MX78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/9555:SLC30A6 ^@ http://purl.uniprot.org/uniprot/A0A096NFQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9555:SEPTIN7 ^@ http://purl.uniprot.org/uniprot/A0A2I3LIJ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cleavage furrow|||Filament-forming cytoskeletal GTPase.|||Midbody|||Septins polymerize into heterooligomeric protein complexes that form filaments.|||cilium axoneme|||flagellum|||kinetochore|||spindle http://togogenome.org/gene/9555:FSHB ^@ http://purl.uniprot.org/uniprot/A0A8I5R6E2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/9555:XKR6 ^@ http://purl.uniprot.org/uniprot/A0A096N118 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9555:FBN1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LFX8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fibrillin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9555:SH3BP5 ^@ http://purl.uniprot.org/uniprot/A0A096MKU5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SH3BP5 family.|||Cytoplasm|||Functions as guanine nucleotide exchange factor (GEF) for RAB11A.|||Interacts with GDP-bound and nucleotide-free forms of RAB11A.|||The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape. http://togogenome.org/gene/9555:CD47 ^@ http://purl.uniprot.org/uniprot/A0A096NQZ6|||http://purl.uniprot.org/uniprot/A0A2I3LIZ4|||http://purl.uniprot.org/uniprot/A0A8I5NS18 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9555:ZSCAN30 ^@ http://purl.uniprot.org/uniprot/A0A096MU35 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:NPAS1 ^@ http://purl.uniprot.org/uniprot/A0A0A0MUE7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:AVL9 ^@ http://purl.uniprot.org/uniprot/A0A096P049 ^@ Subcellular Location Annotation ^@ Recycling endosome http://togogenome.org/gene/9555:GAB3 ^@ http://purl.uniprot.org/uniprot/A0A096N703 ^@ Similarity ^@ Belongs to the GAB family. http://togogenome.org/gene/9555:GPRIN3 ^@ http://purl.uniprot.org/uniprot/A0A8I5MYW9 ^@ Function ^@ May be involved in neurite outgrowth. http://togogenome.org/gene/9555:GET1 ^@ http://purl.uniprot.org/uniprot/A0A8I5N228|||http://purl.uniprot.org/uniprot/B0CM35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WRB/GET1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:LOC101002372 ^@ http://purl.uniprot.org/uniprot/A0A2I3LG87 ^@ Similarity ^@ Belongs to the SPAN-X family. http://togogenome.org/gene/9555:PSMC4 ^@ http://purl.uniprot.org/uniprot/A0A0A0MV92 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9555:KCNH1 ^@ http://purl.uniprot.org/uniprot/A0A096N8P3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:LOC101014344 ^@ http://purl.uniprot.org/uniprot/A0A2I3LHZ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCC3 family.|||Membrane|||Mitochondrion inner membrane|||Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology. http://togogenome.org/gene/9555:ERN1 ^@ http://purl.uniprot.org/uniprot/A0A2I3N376 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:LOC101004009 ^@ http://purl.uniprot.org/uniprot/A0A096MR93 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/9555:BUD13 ^@ http://purl.uniprot.org/uniprot/A9CB26 ^@ Similarity ^@ Belongs to the CWC26 family. http://togogenome.org/gene/9555:PGLYRP1 ^@ http://purl.uniprot.org/uniprot/A0A8I5N8A2 ^@ Function|||Similarity ^@ Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.|||Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. http://togogenome.org/gene/9555:CCDC86 ^@ http://purl.uniprot.org/uniprot/A0A096MUS3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:RANBP17 ^@ http://purl.uniprot.org/uniprot/A0A096N441 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:GDF5 ^@ http://purl.uniprot.org/uniprot/B0CM78 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9555:RPRD1A ^@ http://purl.uniprot.org/uniprot/A0A2I3ME04|||http://purl.uniprot.org/uniprot/A0A2I3MTT8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the RNA polymerase II complex.|||Belongs to the UPF0400 (RTT103) family.|||Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.|||Nucleus http://togogenome.org/gene/9555:LOC101003703 ^@ http://purl.uniprot.org/uniprot/A0A096N4U1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eS7 family.|||centrosome http://togogenome.org/gene/9555:ME1 ^@ http://purl.uniprot.org/uniprot/A0A096NUI3 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/9555:DNPH1 ^@ http://purl.uniprot.org/uniprot/A0A096NIC2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.|||Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.|||Cytoplasm|||Monomer and homodimer.|||Nucleus http://togogenome.org/gene/9555:CD28 ^@ http://purl.uniprot.org/uniprot/A0A2I3N9H4|||http://purl.uniprot.org/uniprot/Q9BDN8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:FZD4 ^@ http://purl.uniprot.org/uniprot/A0A8I5MWG7|||http://purl.uniprot.org/uniprot/A0A8I5MYT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:RNPC3 ^@ http://purl.uniprot.org/uniprot/A0A096MRG8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Found in a complex with m(7)G-capped U12 snRNA. Interacts with PDCD7.|||Nucleus|||Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA. http://togogenome.org/gene/9555:NPTX1 ^@ http://purl.uniprot.org/uniprot/A0A8I5R531 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:TCP11L2 ^@ http://purl.uniprot.org/uniprot/A0A096N8X4 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/9555:PLPPR4 ^@ http://purl.uniprot.org/uniprot/A0A8I5NMH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9555:RAB29 ^@ http://purl.uniprot.org/uniprot/A0A096MPU0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/9555:VPS37B ^@ http://purl.uniprot.org/uniprot/A0A096N561 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9555:ZC3HAV1 ^@ http://purl.uniprot.org/uniprot/A0A096NY80 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9555:ABCD1 ^@ http://purl.uniprot.org/uniprot/A0A096ML52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9555:TENT5D ^@ http://purl.uniprot.org/uniprot/A0A8I5R5N4 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/9555:ERAL1 ^@ http://purl.uniprot.org/uniprot/A0A096P3F0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.|||Membrane|||Mitochondrion inner membrane|||Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly. http://togogenome.org/gene/9555:SERPINB13 ^@ http://purl.uniprot.org/uniprot/A9RA90 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9555:OR51F2 ^@ http://purl.uniprot.org/uniprot/A9L901 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:LPAR3 ^@ http://purl.uniprot.org/uniprot/A0A096N292 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:TMEM145 ^@ http://purl.uniprot.org/uniprot/A0A0A0MV13 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:POLR2G ^@ http://purl.uniprot.org/uniprot/A0A2I3MQI4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.|||DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/9555:MAF1 ^@ http://purl.uniprot.org/uniprot/A0A096P3K3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MAF1 family.|||Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.|||Nucleus http://togogenome.org/gene/9555:VAX1 ^@ http://purl.uniprot.org/uniprot/A0A096NTV3|||http://purl.uniprot.org/uniprot/A0A2I3MYP1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:DLD ^@ http://purl.uniprot.org/uniprot/A0A096NF79 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond.|||acrosome|||flagellum http://togogenome.org/gene/9555:PLPP4 ^@ http://purl.uniprot.org/uniprot/A0A2I3MND4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9555:GCK ^@ http://purl.uniprot.org/uniprot/A0A2I3MKI5 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/9555:NUDT12 ^@ http://purl.uniprot.org/uniprot/A0A096MMX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Nudix hydrolase family. NudC subfamily.|||Cytoplasmic granule|||Peroxisome http://togogenome.org/gene/9555:MRFAP1L1 ^@ http://purl.uniprot.org/uniprot/A0A8I5N0M6 ^@ Similarity ^@ Belongs to the MORF4 family-associated protein family. http://togogenome.org/gene/9555:CNIH2 ^@ http://purl.uniprot.org/uniprot/A0A096MNT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/9555:LOC101015137 ^@ http://purl.uniprot.org/uniprot/A0A2I3MZE4 ^@ Similarity|||Subunit ^@ Belongs to the GST superfamily. Theta family.|||Homodimer. http://togogenome.org/gene/9555:BECN1 ^@ http://purl.uniprot.org/uniprot/A0A096P5V6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.|||Belongs to the beclin family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Endosome membrane|||Membrane|||Mitochondrion membrane|||Plays a central role in autophagy.|||autophagosome|||trans-Golgi network membrane http://togogenome.org/gene/9555:ASPA ^@ http://purl.uniprot.org/uniprot/A0A096P2D8 ^@ Cofactor|||Similarity ^@ Belongs to the AspA/AstE family. Aspartoacylase subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9555:SPATA18 ^@ http://purl.uniprot.org/uniprot/A0A096N2F4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIEAP family.|||Cytoplasm|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9555:PPIL2 ^@ http://purl.uniprot.org/uniprot/A0A2I3N2V1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.|||Nucleus http://togogenome.org/gene/9555:CIT ^@ http://purl.uniprot.org/uniprot/A0A2I3LJ38|||http://purl.uniprot.org/uniprot/A0A2I3MKN8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.|||Cytoplasm|||Plays a role in cytokinesis. Displays serine/threonine protein kinase activity. http://togogenome.org/gene/9555:NPM1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MVB3 ^@ Similarity ^@ Belongs to the nucleoplasmin family. http://togogenome.org/gene/9555:SPDYE4 ^@ http://purl.uniprot.org/uniprot/A0A096P2V8 ^@ Similarity ^@ Belongs to the Speedy/Ringo family. http://togogenome.org/gene/9555:LOC103885453 ^@ http://purl.uniprot.org/uniprot/A0A096N740|||http://purl.uniprot.org/uniprot/A0A8I5N8S8 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. http://togogenome.org/gene/9555:CCNF ^@ http://purl.uniprot.org/uniprot/A0A096NL52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclin family.|||Nucleus|||centriole|||perinuclear region http://togogenome.org/gene/9555:PSMG1 ^@ http://purl.uniprot.org/uniprot/B0CM32 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PSMG1 family.|||Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization (By similarity).|||Cytoplasm|||Degraded by the proteasome upon completion of 20S proteasome maturation.|||Endoplasmic reticulum|||Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits (By similarity). http://togogenome.org/gene/9555:MAP1LC3A ^@ http://purl.uniprot.org/uniprot/A0A2I3MQN7 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9555:EIF6 ^@ http://purl.uniprot.org/uniprot/A0A096NUQ0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-6 family.|||Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.|||Cytoplasm|||Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).|||Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.|||nucleolus http://togogenome.org/gene/9555:RNF20 ^@ http://purl.uniprot.org/uniprot/A0A096P101 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BRE1 family.|||Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.|||Nucleus http://togogenome.org/gene/9555:HS2ST1 ^@ http://purl.uniprot.org/uniprot/A0A8I5N5W8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 3 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9555:HNRNPK ^@ http://purl.uniprot.org/uniprot/A0A2I3LSM4 ^@ Subcellular Location Annotation ^@ Cytoplasm|||nucleoplasm|||podosome http://togogenome.org/gene/9555:ERRFI1 ^@ http://purl.uniprot.org/uniprot/A0A096N4S6 ^@ Subcellular Location Annotation ^@ Membrane|||Nucleus http://togogenome.org/gene/9555:REEP4 ^@ http://purl.uniprot.org/uniprot/A0A2I3MTB3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:LANCL1 ^@ http://purl.uniprot.org/uniprot/A0A096MVE3 ^@ Similarity ^@ Belongs to the LanC-like protein family. http://togogenome.org/gene/9555:PHYHIP ^@ http://purl.uniprot.org/uniprot/A0A096N2V5 ^@ Similarity ^@ Belongs to the PHYHIP family. http://togogenome.org/gene/9555:LOC101021713 ^@ http://purl.uniprot.org/uniprot/A0A096P6D9 ^@ Similarity ^@ Belongs to the TACO1 family. http://togogenome.org/gene/9555:PDP2 ^@ http://purl.uniprot.org/uniprot/A0A096NJ94 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9555:KCNK10 ^@ http://purl.uniprot.org/uniprot/A0A096NRB4|||http://purl.uniprot.org/uniprot/A0A2I3M1S6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9555:LOC101011139 ^@ http://purl.uniprot.org/uniprot/A0A096MX89 ^@ Function|||Similarity ^@ Belongs to the PET191 family.|||Involved in an early step of the mitochondrial complex IV assembly process. http://togogenome.org/gene/9555:LOC101025325 ^@ http://purl.uniprot.org/uniprot/A0A2I3N1N3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/9555:TVP23A ^@ http://purl.uniprot.org/uniprot/A0A096NLN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP23 family.|||Membrane http://togogenome.org/gene/9555:GPR12 ^@ http://purl.uniprot.org/uniprot/A0A096MKY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:MED31 ^@ http://purl.uniprot.org/uniprot/A0A8I5R047 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 31 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9555:SFRP4 ^@ http://purl.uniprot.org/uniprot/A0A8I5R9I7 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:RUVBL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MHQ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RuvB family.|||Dynein axonemal particle|||Nucleus|||Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. http://togogenome.org/gene/9555:TAS2R8 ^@ http://purl.uniprot.org/uniprot/A0A8I5NI85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9555:BEST1 ^@ http://purl.uniprot.org/uniprot/A0A096NB81 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms calcium-sensitive chloride channels. Permeable to bicarbonate.|||Membrane http://togogenome.org/gene/9555:TRMT13 ^@ http://purl.uniprot.org/uniprot/A0A096NCZ8 ^@ Function|||Similarity ^@ Belongs to the methyltransferase TRM13 family.|||tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His). http://togogenome.org/gene/9555:TACR1 ^@ http://purl.uniprot.org/uniprot/A0A096N5A2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with ARRB1.|||Membrane http://togogenome.org/gene/9555:FAM161A ^@ http://purl.uniprot.org/uniprot/A0A096NXT5|||http://purl.uniprot.org/uniprot/A0A2I3MP87 ^@ Similarity ^@ Belongs to the FAM161 family. http://togogenome.org/gene/9555:CREB1 ^@ http://purl.uniprot.org/uniprot/A0A096MS95|||http://purl.uniprot.org/uniprot/A0A2I3M6F6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:PKM ^@ http://purl.uniprot.org/uniprot/A0A096NMM2|||http://purl.uniprot.org/uniprot/A0A2I3LDP7|||http://purl.uniprot.org/uniprot/A0A2I3MSK7 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/9555:PCYOX1L ^@ http://purl.uniprot.org/uniprot/A0A096MLR2|||http://purl.uniprot.org/uniprot/A0A8I5NK03 ^@ Similarity ^@ Belongs to the prenylcysteine oxidase family. http://togogenome.org/gene/9555:HNRNPA2B1 ^@ http://purl.uniprot.org/uniprot/A0A2I3M8I3 ^@ Subcellular Location Annotation ^@ Cytoplasmic granule http://togogenome.org/gene/9555:ORC4 ^@ http://purl.uniprot.org/uniprot/A0A096NSM6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC4 family.|||Component of the origin recognition complex (ORC) that binds origins of replication.|||Nucleus http://togogenome.org/gene/9555:TLR7 ^@ http://purl.uniprot.org/uniprot/A0A096N836 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9555:RIPPLY2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NFU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ripply family.|||Nucleus http://togogenome.org/gene/9555:RTN2 ^@ http://purl.uniprot.org/uniprot/A0A0A0MXE7|||http://purl.uniprot.org/uniprot/A0A2I3NFM5 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:KCNK17 ^@ http://purl.uniprot.org/uniprot/A0A096NHZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9555:HOXA1 ^@ http://purl.uniprot.org/uniprot/A9L936 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Labial subfamily.|||Nucleus http://togogenome.org/gene/9555:ACOT13 ^@ http://purl.uniprot.org/uniprot/A0A2I3NCE5 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/9555:TEKT1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NDX0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/9555:COPE ^@ http://purl.uniprot.org/uniprot/A0A0A0MTZ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPE family.|||Cytoplasm|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. http://togogenome.org/gene/9555:RDH12 ^@ http://purl.uniprot.org/uniprot/A0A096NVQ8 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9555:LOC101021552 ^@ http://purl.uniprot.org/uniprot/A0A2I3MBA7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS26 family. http://togogenome.org/gene/9555:LIMD1 ^@ http://purl.uniprot.org/uniprot/A0A096N113 ^@ Similarity ^@ Belongs to the zyxin/ajuba family. http://togogenome.org/gene/9555:CTSO ^@ http://purl.uniprot.org/uniprot/A0A8I5MYH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9555:B3GAT3 ^@ http://purl.uniprot.org/uniprot/A0A096MKQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9555:SLC25A38 ^@ http://purl.uniprot.org/uniprot/A0A2I3M738 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.|||Membrane|||Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.|||Mitochondrion inner membrane|||Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis. http://togogenome.org/gene/9555:MON2 ^@ http://purl.uniprot.org/uniprot/A0A096MRP8 ^@ Similarity ^@ Belongs to the MON2 family. http://togogenome.org/gene/9555:ZSCAN31 ^@ http://purl.uniprot.org/uniprot/A0A096NLK9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:RNF34 ^@ http://purl.uniprot.org/uniprot/A0A096N4C0|||http://purl.uniprot.org/uniprot/A0A2I3MQH7 ^@ Subcellular Location Annotation ^@ Cell membrane|||cytosol http://togogenome.org/gene/9555:CTTNBP2 ^@ http://purl.uniprot.org/uniprot/A0M8S4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with CTTN/cortactin SH3 domain. Interacts with STRN, STRN4/zinedin and MOB4/phocein; this interaction may regulate dendritic spine distribution of STRN and STRN4 in hippocampal neurons. Activation of glutamate receptors weakens the interaction with STRN and STRN4.|||Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.|||cell cortex|||dendritic spine http://togogenome.org/gene/9555:DTX4 ^@ http://purl.uniprot.org/uniprot/A0A096MW78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Deltex family.|||Cytoplasm http://togogenome.org/gene/9555:CD79A ^@ http://purl.uniprot.org/uniprot/A0A0A0MU29 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9555:ZNF215 ^@ http://purl.uniprot.org/uniprot/A0A096MLJ6|||http://purl.uniprot.org/uniprot/A0A2I3MQX7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:CCL21 ^@ http://purl.uniprot.org/uniprot/A0A8I5R6Z6 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9555:DBP ^@ http://purl.uniprot.org/uniprot/A0A0A0MU31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/9555:SPOCK2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NCS3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:LOC100997079 ^@ http://purl.uniprot.org/uniprot/A0A096N933 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9555:TMEM53 ^@ http://purl.uniprot.org/uniprot/A0A2I3M1F7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM53 family.|||Membrane|||Nucleus outer membrane http://togogenome.org/gene/9555:ANO8 ^@ http://purl.uniprot.org/uniprot/A0A0A0MVP4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:PGGT1B ^@ http://purl.uniprot.org/uniprot/A0A096MMJ7 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit beta family. http://togogenome.org/gene/9555:TNP1 ^@ http://purl.uniprot.org/uniprot/A0A8I5N9B4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear transition protein 1 family.|||Chromosome|||Nucleus http://togogenome.org/gene/9555:RGS9BP ^@ http://purl.uniprot.org/uniprot/A0A0A0MVM2 ^@ Similarity ^@ Belongs to the RGS7BP/RGS9BP family. http://togogenome.org/gene/9555:LOC103878644 ^@ http://purl.uniprot.org/uniprot/A0A8I5NM80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 54 family.|||Golgi apparatus membrane http://togogenome.org/gene/9555:SLC17A5 ^@ http://purl.uniprot.org/uniprot/A0A8I5NTK8|||http://purl.uniprot.org/uniprot/A9X190 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:GABRR2 ^@ http://purl.uniprot.org/uniprot/A0A2I3M9K4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9555:SLC52A3 ^@ http://purl.uniprot.org/uniprot/A0A8I5N8K9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the riboflavin transporter family.|||Cell membrane|||Membrane|||Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. http://togogenome.org/gene/9555:FMC1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NNU4 ^@ Similarity ^@ Belongs to the FMC1 family. http://togogenome.org/gene/9555:RPL22 ^@ http://purl.uniprot.org/uniprot/A0A096MR24 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL22 family. http://togogenome.org/gene/9555:HDHD3 ^@ http://purl.uniprot.org/uniprot/A0A096N8Q4 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/9555:INPP5K ^@ http://purl.uniprot.org/uniprot/A0A096P299 ^@ Similarity ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family. http://togogenome.org/gene/9555:SNF8 ^@ http://purl.uniprot.org/uniprot/A0A2I3LLB2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SNF8 family.|||Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II). http://togogenome.org/gene/9555:FSCN1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NP93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fascin family.|||cytoskeleton http://togogenome.org/gene/9555:NDUFS6 ^@ http://purl.uniprot.org/uniprot/A0A096N4A6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS6 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:SLCO2A1 ^@ http://purl.uniprot.org/uniprot/A0A2I3N7F0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:PLN ^@ http://purl.uniprot.org/uniprot/A0A096MLY7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phospholamban family.|||Endoplasmic reticulum membrane|||Homopentamer.|||Membrane|||Mitochondrion membrane|||Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/9555:CRY1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NYU8 ^@ Cofactor|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/9555:BANF1 ^@ http://purl.uniprot.org/uniprot/A0A096MLS4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:LOC101016814 ^@ http://purl.uniprot.org/uniprot/A0A2I3N7A7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/9555:ETV6 ^@ http://purl.uniprot.org/uniprot/A0A2I3M449 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9555:AMIGO2 ^@ http://purl.uniprot.org/uniprot/A0A096NCW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. AMIGO family.|||Membrane http://togogenome.org/gene/9555:RPS9 ^@ http://purl.uniprot.org/uniprot/A9L913 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.|||Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.|||Cytoplasm|||nucleolus http://togogenome.org/gene/9555:SLC25A2 ^@ http://purl.uniprot.org/uniprot/A0A096NC50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9555:SLC16A13 ^@ http://purl.uniprot.org/uniprot/A0A096P2M2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:CCNE1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NAP7 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9555:PAXBP1 ^@ http://purl.uniprot.org/uniprot/A9CAZ1 ^@ Similarity ^@ Belongs to the GCF family. http://togogenome.org/gene/9555:SLC30A3 ^@ http://purl.uniprot.org/uniprot/A0A2I3N9Q5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9555:SAMD4A ^@ http://purl.uniprot.org/uniprot/A0A096NV59|||http://purl.uniprot.org/uniprot/A0A2I3MBB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMAUG family.|||Cytoplasm http://togogenome.org/gene/9555:IPPK ^@ http://purl.uniprot.org/uniprot/A0A096P240 ^@ Domain|||Function|||Similarity ^@ Belongs to the IPK1 type 2 family.|||Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).|||The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2. http://togogenome.org/gene/9555:SYNM ^@ http://purl.uniprot.org/uniprot/A0A096NND4|||http://purl.uniprot.org/uniprot/A0A8I5NGI5 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9555:NID2 ^@ http://purl.uniprot.org/uniprot/A0A096NUZ8|||http://purl.uniprot.org/uniprot/A0A2I3LIZ5|||http://purl.uniprot.org/uniprot/A0A2I3NHH2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/9555:KCNE5 ^@ http://purl.uniprot.org/uniprot/A0A8I5N2F7 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/9555:CD3D ^@ http://purl.uniprot.org/uniprot/A0A2I3LRB2|||http://purl.uniprot.org/uniprot/A0A2I3MIM7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:TMEM208 ^@ http://purl.uniprot.org/uniprot/A0A2I3LC39 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM208 family.|||Endoplasmic reticulum membrane|||May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.|||Membrane http://togogenome.org/gene/9555:PHF20L1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MTR0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:POLA2 ^@ http://purl.uniprot.org/uniprot/A0A096N2C0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.|||Belongs to the DNA polymerase alpha subunit B family.|||Nucleus http://togogenome.org/gene/9555:TMEM170A ^@ http://purl.uniprot.org/uniprot/A0A2I3N2D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM170 family.|||Membrane http://togogenome.org/gene/9555:CPNE2 ^@ http://purl.uniprot.org/uniprot/A0A096NIP9 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9555:MED27 ^@ http://purl.uniprot.org/uniprot/A0A096P0E5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 27 family.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9555:HOXB1 ^@ http://purl.uniprot.org/uniprot/A0A096P422 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Labial subfamily.|||Nucleus http://togogenome.org/gene/9555:PSPC1 ^@ http://purl.uniprot.org/uniprot/A0A096NAX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PSPC family.|||Cytoplasm|||Nucleus matrix|||Nucleus speckle|||nucleolus http://togogenome.org/gene/9555:ICAM1 ^@ http://purl.uniprot.org/uniprot/A0A0A0MV70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. ICAM family.|||Membrane http://togogenome.org/gene/9555:RDM1 ^@ http://purl.uniprot.org/uniprot/A0A096P3Y5|||http://purl.uniprot.org/uniprot/A0A2I3MFI3 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Homodimer.|||nucleolus http://togogenome.org/gene/9555:PDGFB ^@ http://purl.uniprot.org/uniprot/A0A2I3NCD7 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/9555:MYH10 ^@ http://purl.uniprot.org/uniprot/A0A096P2V3|||http://purl.uniprot.org/uniprot/A0A2I3LJS5|||http://purl.uniprot.org/uniprot/A0A2I3NAJ8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9555:LOC101007251 ^@ http://purl.uniprot.org/uniprot/A0A8I5NTY2 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9555:SDHAF1 ^@ http://purl.uniprot.org/uniprot/A0A0A0MVB5 ^@ Similarity ^@ Belongs to the complex I LYR family. SDHAF1 subfamily. http://togogenome.org/gene/9555:RPL7A ^@ http://purl.uniprot.org/uniprot/A0A096P0D1 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Component of the ribosome. http://togogenome.org/gene/9555:HPDL ^@ http://purl.uniprot.org/uniprot/A0A8I5P0B2 ^@ Cofactor|||Similarity ^@ Belongs to the 4HPPD family.|||Binds 1 Fe cation per subunit. http://togogenome.org/gene/9555:PDCD4 ^@ http://purl.uniprot.org/uniprot/A0A2I3MDN3 ^@ Similarity ^@ Belongs to the PDCD4 family. http://togogenome.org/gene/9555:MT4 ^@ http://purl.uniprot.org/uniprot/A0A096NII3 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9555:SGMS1 ^@ http://purl.uniprot.org/uniprot/A0A096P5A4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/9555:LOC101025645 ^@ http://purl.uniprot.org/uniprot/A0A096N1Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clusterin family.|||Endoplasmic reticulum|||Membrane|||Microsome|||Mitochondrion membrane|||Nucleus|||Secreted|||chromaffin granule|||cytosol|||perinuclear region http://togogenome.org/gene/9555:STOML2 ^@ http://purl.uniprot.org/uniprot/A0A096P190 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/9555:APOD ^@ http://purl.uniprot.org/uniprot/A0A096N1J7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family.|||Homodimer.|||Secreted http://togogenome.org/gene/9555:FEZ2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MTL6|||http://purl.uniprot.org/uniprot/A0A8I5R0F0 ^@ Similarity ^@ Belongs to the zygin family. http://togogenome.org/gene/9555:UCN ^@ http://purl.uniprot.org/uniprot/A0A8I5MXV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Secreted http://togogenome.org/gene/9555:CBS ^@ http://purl.uniprot.org/uniprot/A0A096NIQ5|||http://purl.uniprot.org/uniprot/A0A096NIQ7 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/9555:CTSS ^@ http://purl.uniprot.org/uniprot/A0A096NFN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9555:TRPM8 ^@ http://purl.uniprot.org/uniprot/A9RAA2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:ACTL7A ^@ http://purl.uniprot.org/uniprot/A0A096NCG1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the actin family.|||Golgi apparatus|||May play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis.|||Nucleus|||cytoskeleton http://togogenome.org/gene/9555:PAGE4 ^@ http://purl.uniprot.org/uniprot/A0A096NB63|||http://purl.uniprot.org/uniprot/A0A8I5NGB7 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9555:FAM83A ^@ http://purl.uniprot.org/uniprot/A0A096NRJ8 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9555:ZNRF4 ^@ http://purl.uniprot.org/uniprot/A0A8I5NU12 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:BCL2L1 ^@ http://purl.uniprot.org/uniprot/A0A8I5MVB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Membrane|||Mitochondrion matrix|||Nucleus membrane|||centrosome|||cytosol|||synaptic vesicle membrane http://togogenome.org/gene/9555:FBP2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NN65 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/9555:ALKBH7 ^@ http://purl.uniprot.org/uniprot/A0A2I3MF45 ^@ Similarity ^@ Belongs to the alkB family. http://togogenome.org/gene/9555:PPP1R3B ^@ http://purl.uniprot.org/uniprot/A0A096MLQ4 ^@ Subunit ^@ Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity. http://togogenome.org/gene/9555:SBDS ^@ http://purl.uniprot.org/uniprot/A0A096NY31 ^@ Function|||Similarity ^@ Belongs to the SDO1/SBDS family.|||Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. http://togogenome.org/gene/9555:AGA ^@ http://purl.uniprot.org/uniprot/A0A096NQL2 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/9555:POLR2C ^@ http://purl.uniprot.org/uniprot/A0A096NIT0 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/9555:CPEB2 ^@ http://purl.uniprot.org/uniprot/A0A096NZF7|||http://purl.uniprot.org/uniprot/A0A2I3LFL3|||http://purl.uniprot.org/uniprot/A0A2I3MBS9 ^@ Similarity ^@ Belongs to the RRM CPEB family. http://togogenome.org/gene/9555:CAPZA2 ^@ http://purl.uniprot.org/uniprot/A0M8R8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).|||Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5. Interacts with RCSD1/CAPZIP (By similarity). http://togogenome.org/gene/9555:TUBGCP4 ^@ http://purl.uniprot.org/uniprot/A0A096N6U6|||http://purl.uniprot.org/uniprot/A9X1B2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.|||centrosome http://togogenome.org/gene/9555:SMU1 ^@ http://purl.uniprot.org/uniprot/A0A096P1D0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SMU1 family.|||Nucleus speckle http://togogenome.org/gene/9555:ZIC1 ^@ http://purl.uniprot.org/uniprot/A0A096N234 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/9555:ID4 ^@ http://purl.uniprot.org/uniprot/A0A8I5NBA5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:TINAG ^@ http://purl.uniprot.org/uniprot/A0A2I3N0N4 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/9555:IGFBP6 ^@ http://purl.uniprot.org/uniprot/A0A096N7M7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9555:HCN1 ^@ http://purl.uniprot.org/uniprot/A0A096MWN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel HCN family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:HSPA9 ^@ http://purl.uniprot.org/uniprot/A0A096MUK6 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9555:POU2F2 ^@ http://purl.uniprot.org/uniprot/A0A0A0MVF0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-2 subfamily.|||Nucleus|||Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. http://togogenome.org/gene/9555:NIPA1 ^@ http://purl.uniprot.org/uniprot/A0A096NT02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9555:TRIM4 ^@ http://purl.uniprot.org/uniprot/A0A096NDN7 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9555:ANKRD34C ^@ http://purl.uniprot.org/uniprot/A0A096N5Y0 ^@ Similarity ^@ Belongs to the ANKRD34 family. http://togogenome.org/gene/9555:DHX58 ^@ http://purl.uniprot.org/uniprot/A0A2I3NCQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/9555:CTSH ^@ http://purl.uniprot.org/uniprot/A0A2I3MPT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9555:DCLRE1B ^@ http://purl.uniprot.org/uniprot/A0A2I3MFW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/9555:USE1 ^@ http://purl.uniprot.org/uniprot/A0A0A0MWZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the USE1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:CNRIP1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NPT2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CNRIP family.|||Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.|||Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. http://togogenome.org/gene/9555:RNF146 ^@ http://purl.uniprot.org/uniprot/A0A2I3M2L6 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Can form homooligomers. Interacts with PARsylated AXIN1, AXIN2, BLZF1, CASC3, H1-2, IPO7, LIG3, NCL, PARP1, XRCC1, XRCC5 and XRCC6. Interacts with DDB1, DHX15, IQGAP1, LRPPRC, PARP2, PRKDC, RUVBL2, TNKS1 and TNKS2. Binding often leads to interactor ubiquitination, in the presence of the appropriate E1 and E2 enzymes, and proteasomal degradation.|||E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.|||The WWE domain mediates non-covalent poly(ADP-ribose)-binding.|||Ubiquitinated; autoubiquitinated.|||cytosol http://togogenome.org/gene/9555:KRT17 ^@ http://purl.uniprot.org/uniprot/A0A096P5N8 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9555:KCNJ9 ^@ http://purl.uniprot.org/uniprot/A0A096N4D9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9555:SLC17A1 ^@ http://purl.uniprot.org/uniprot/A0A096NLF0|||http://purl.uniprot.org/uniprot/A0A2I3MJ39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.|||Membrane http://togogenome.org/gene/9555:HS6ST3 ^@ http://purl.uniprot.org/uniprot/A0A096NEL8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.|||Belongs to the sulfotransferase 6 family.|||Membrane http://togogenome.org/gene/9555:LALBA ^@ http://purl.uniprot.org/uniprot/A0A8I5R503 ^@ Function|||Similarity ^@ Belongs to the glycosyl hydrolase 22 family.|||Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins. http://togogenome.org/gene/9555:FOXJ3 ^@ http://purl.uniprot.org/uniprot/A0A096MKU3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:CHST11 ^@ http://purl.uniprot.org/uniprot/A0A8I5R1B4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9555:NOTO ^@ http://purl.uniprot.org/uniprot/A0A8I5NAT8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:KMT5C ^@ http://purl.uniprot.org/uniprot/A0A0A0MWH9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:LOC101009534 ^@ http://purl.uniprot.org/uniprot/A0A2I3MLY1|||http://purl.uniprot.org/uniprot/A0A2I3NI35 ^@ Similarity ^@ Belongs to the BRAG family. http://togogenome.org/gene/9555:ELOVL3 ^@ http://purl.uniprot.org/uniprot/A0A096P6D7 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL3 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||N-Glycosylated.|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9555:PCYOX1 ^@ http://purl.uniprot.org/uniprot/A0A096NPE9 ^@ Similarity ^@ Belongs to the prenylcysteine oxidase family. http://togogenome.org/gene/9555:LOC101011357 ^@ http://purl.uniprot.org/uniprot/A0A096MP40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/9555:PDGFC ^@ http://purl.uniprot.org/uniprot/A0A096NQR2 ^@ Caution|||Similarity ^@ Belongs to the PDGF/VEGF growth factor family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:GDAP2 ^@ http://purl.uniprot.org/uniprot/A0A096N7W5 ^@ Similarity ^@ Belongs to the GDAP2 family. http://togogenome.org/gene/9555:CD53 ^@ http://purl.uniprot.org/uniprot/A0A096N491 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9555:ADAT2 ^@ http://purl.uniprot.org/uniprot/A0A096N2Q4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.|||Cytoplasm|||Probably participates in deamination of adenosine-34 to inosine in many tRNAs. http://togogenome.org/gene/9555:CD36 ^@ http://purl.uniprot.org/uniprot/A0A096NER7 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/9555:FZD5 ^@ http://purl.uniprot.org/uniprot/A0A096N985 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:NFIB ^@ http://purl.uniprot.org/uniprot/A0A096P1I8|||http://purl.uniprot.org/uniprot/A0A2I3M5C8|||http://purl.uniprot.org/uniprot/A0A2I3MIN4|||http://purl.uniprot.org/uniprot/A0A2I3NH97 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTF/NF-I family.|||Binds DNA as a homodimer.|||Nucleus|||Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. http://togogenome.org/gene/9555:DENND6A ^@ http://purl.uniprot.org/uniprot/A0A096NGP4|||http://purl.uniprot.org/uniprot/A0A2I3LKT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DENND6 family.|||Recycling endosome http://togogenome.org/gene/9555:MALSU1 ^@ http://purl.uniprot.org/uniprot/A0A096NW03 ^@ Similarity ^@ Belongs to the Iojap/RsfS family. http://togogenome.org/gene/9555:HDAC3 ^@ http://purl.uniprot.org/uniprot/A0A096MPL2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.|||Nucleus http://togogenome.org/gene/9555:CREB5 ^@ http://purl.uniprot.org/uniprot/A0A2I3LF32 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bZIP family.|||Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1.|||Binds to the cAMP response element and activates transcription.|||Nucleus http://togogenome.org/gene/9555:RGS3 ^@ http://purl.uniprot.org/uniprot/A0A096P0T4|||http://purl.uniprot.org/uniprot/A0A2I3MW58 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:RAB3C ^@ http://purl.uniprot.org/uniprot/A0A8I5NYM7|||http://purl.uniprot.org/uniprot/A0A8I5QZV9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/9555:POLD2 ^@ http://purl.uniprot.org/uniprot/A0A096NYS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase delta/II small subunit family.|||Nucleus http://togogenome.org/gene/9555:SEPTIN9 ^@ http://purl.uniprot.org/uniprot/A0A096NT54|||http://purl.uniprot.org/uniprot/A0A2I3M0P8|||http://purl.uniprot.org/uniprot/A0A2I3MU34 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/9555:LOC101019822 ^@ http://purl.uniprot.org/uniprot/A0A096P2Z0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiA prenyltransferase family.|||Converts protoheme IX and farnesyl diphosphate to heme O.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9555:ABI3 ^@ http://purl.uniprot.org/uniprot/A0A8I5R1X8 ^@ Similarity ^@ Belongs to the ABI family. http://togogenome.org/gene/9555:FGFR1OP2 ^@ http://purl.uniprot.org/uniprot/A0A096MWG9|||http://purl.uniprot.org/uniprot/A0A2I3MR60 ^@ Similarity ^@ Belongs to the SIKE family. http://togogenome.org/gene/9555:AKT2 ^@ http://purl.uniprot.org/uniprot/D3VYT7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. http://togogenome.org/gene/9555:IDH2 ^@ http://purl.uniprot.org/uniprot/A0A096NN95 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Homodimer. http://togogenome.org/gene/9555:KAT8 ^@ http://purl.uniprot.org/uniprot/A0A2I3N8X6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/9555:ZNF592 ^@ http://purl.uniprot.org/uniprot/A0A096NN17 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9555:DOK6 ^@ http://purl.uniprot.org/uniprot/A0A2I3NEP3 ^@ Similarity ^@ Belongs to the DOK family. Type B subfamily. http://togogenome.org/gene/9555:AP2S1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MHF3|||http://purl.uniprot.org/uniprot/A0A2I3MTH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cell membrane|||coated pit http://togogenome.org/gene/9555:LMBR1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MEX8 ^@ Similarity ^@ Belongs to the LIMR family. http://togogenome.org/gene/9555:CCN2 ^@ http://purl.uniprot.org/uniprot/A9X180 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9555:TBR1 ^@ http://purl.uniprot.org/uniprot/A0A096MY32 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9555:CRCP ^@ http://purl.uniprot.org/uniprot/A0A2I3MHE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC9 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/9555:RPN1 ^@ http://purl.uniprot.org/uniprot/A0A096MPI1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST1 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/9555:NETO2 ^@ http://purl.uniprot.org/uniprot/A0A2I3M0S5|||http://purl.uniprot.org/uniprot/A0A2I3NCW3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:GRN ^@ http://purl.uniprot.org/uniprot/A0A096P615 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the granulin family.|||Secreted http://togogenome.org/gene/9555:NCAN ^@ http://purl.uniprot.org/uniprot/A0A0A0MWZ7|||http://purl.uniprot.org/uniprot/A0A0A0MXI6 ^@ Caution|||Similarity ^@ Belongs to the aggrecan/versican proteoglycan family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:EBPL ^@ http://purl.uniprot.org/uniprot/A0A096MZV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:STK17B ^@ http://purl.uniprot.org/uniprot/A0A096MYN3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:NOL6 ^@ http://purl.uniprot.org/uniprot/A0A096P1C0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NRAP family.|||Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.|||nucleolus http://togogenome.org/gene/9555:ASIP ^@ http://purl.uniprot.org/uniprot/A1YL70 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).|||Secreted|||The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. http://togogenome.org/gene/9555:PGPEP1 ^@ http://purl.uniprot.org/uniprot/A0A0A0MW47|||http://purl.uniprot.org/uniprot/A0A2I3LDJ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C15 family.|||Cytoplasm|||Removes 5-oxoproline from various penultimate amino acid residues except L-proline. http://togogenome.org/gene/9555:CD81 ^@ http://purl.uniprot.org/uniprot/A0A096MQE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9555:ADCK1 ^@ http://purl.uniprot.org/uniprot/A0A096NSA6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family. http://togogenome.org/gene/9555:LGR4 ^@ http://purl.uniprot.org/uniprot/A0A8I5MUJ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:SNX7 ^@ http://purl.uniprot.org/uniprot/A0A096MLD8 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9555:CHMP1A ^@ http://purl.uniprot.org/uniprot/A0A096NFF9 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9555:CRHBP ^@ http://purl.uniprot.org/uniprot/A0A2I3MN68 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CRF-binding protein family.|||Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.|||Secreted http://togogenome.org/gene/9555:INHBA ^@ http://purl.uniprot.org/uniprot/A0A096NQU0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/9555:TRADD ^@ http://purl.uniprot.org/uniprot/A0A096NJA9 ^@ Subcellular Location Annotation ^@ Nucleus|||cytoskeleton http://togogenome.org/gene/9555:MAPK14 ^@ http://purl.uniprot.org/uniprot/A0A096NHR3|||http://purl.uniprot.org/uniprot/A0A2I3LNN6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9555:TRAF4 ^@ http://purl.uniprot.org/uniprot/A0A096P3D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/9555:TACR2 ^@ http://purl.uniprot.org/uniprot/A0A2I3N7E8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:CTSE ^@ http://purl.uniprot.org/uniprot/A0A096N3G8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Secreted http://togogenome.org/gene/9555:LOC101016349 ^@ http://purl.uniprot.org/uniprot/A0A2I3N161 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom5 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9555:MTTP ^@ http://purl.uniprot.org/uniprot/A0A2I3MW71 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:RFC2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LT78 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/9555:IGFBP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3M2T5|||http://purl.uniprot.org/uniprot/A0A8I5NKC5 ^@ Caution|||Subcellular Location Annotation|||Subunit ^@ Binds IGF2 more than IGF1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9555:AGMAT ^@ http://purl.uniprot.org/uniprot/A0A096N3A3 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/9555:WASHC1 ^@ http://purl.uniprot.org/uniprot/A0A096MNA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WASH1 family.|||Early endosome membrane|||Endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/9555:GRM8 ^@ http://purl.uniprot.org/uniprot/A0A8J8YFC2|||http://purl.uniprot.org/uniprot/A9RA76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:RPL17 ^@ http://purl.uniprot.org/uniprot/A0A2I3LGX5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/9555:LOC101007107 ^@ http://purl.uniprot.org/uniprot/A0A096N379 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ran family.|||GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.|||Nucleus http://togogenome.org/gene/9555:TM2D3 ^@ http://purl.uniprot.org/uniprot/A0A096NNG7|||http://purl.uniprot.org/uniprot/A0A2I3MGP7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:DDB1 ^@ http://purl.uniprot.org/uniprot/A0A096MLK1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DDB1 family.|||Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock.|||Component of the UV-DDB complex.|||Nucleus|||The core of the protein consists of three WD40 beta-propeller domains. http://togogenome.org/gene/9555:MRPL35 ^@ http://purl.uniprot.org/uniprot/A0A096NZY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bL35 family.|||Mitochondrion http://togogenome.org/gene/9555:MAB21L3 ^@ http://purl.uniprot.org/uniprot/A0A096N680 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9555:GSTO1 ^@ http://purl.uniprot.org/uniprot/A0A096P6I7 ^@ Function|||Similarity ^@ Belongs to the GST superfamily. Omega family.|||Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). http://togogenome.org/gene/9555:GPHB5 ^@ http://purl.uniprot.org/uniprot/A0A2I3MAP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/9555:HDAC2 ^@ http://purl.uniprot.org/uniprot/A0A8I5MYU4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.|||Nucleus http://togogenome.org/gene/9555:TRIM41 ^@ http://purl.uniprot.org/uniprot/A0A096MQU8|||http://purl.uniprot.org/uniprot/A0A096NBA9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9555:GSPT1 ^@ http://purl.uniprot.org/uniprot/A0A096NLR6 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. http://togogenome.org/gene/9555:KLRK1 ^@ http://purl.uniprot.org/uniprot/A3RLP6 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9555:INPP4B ^@ http://purl.uniprot.org/uniprot/A0A096N8Z7 ^@ Similarity ^@ Belongs to the inositol 3,4-bisphosphate 4-phosphatase family. http://togogenome.org/gene/9555:CRLS1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LVT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/9555:XRCC3 ^@ http://purl.uniprot.org/uniprot/A0A096NJZ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Cytoplasm|||Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.|||Nucleus http://togogenome.org/gene/9555:AHCYL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3M6A6 ^@ Similarity ^@ Belongs to the adenosylhomocysteinase family. http://togogenome.org/gene/9555:KCNC1 ^@ http://purl.uniprot.org/uniprot/A0A096NU98 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9555:TMED7 ^@ http://purl.uniprot.org/uniprot/A0A8I5MUS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9555:SYNPR ^@ http://purl.uniprot.org/uniprot/A0A2I3LQ20|||http://purl.uniprot.org/uniprot/A0A2I3MHF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/9555:RPL31 ^@ http://purl.uniprot.org/uniprot/A0A2I3LUQ6 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL31 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/9555:ELOVL4 ^@ http://purl.uniprot.org/uniprot/A0A096NQ85 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ELO family. ELOVL4 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.|||Endoplasmic reticulum membrane|||Membrane|||Oligomer.|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9555:GALK2 ^@ http://purl.uniprot.org/uniprot/A0A096NM18|||http://purl.uniprot.org/uniprot/A0A2I3NHV7 ^@ Similarity ^@ Belongs to the GHMP kinase family. GalK subfamily. http://togogenome.org/gene/9555:ACAD11 ^@ http://purl.uniprot.org/uniprot/A0A096MLX9 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9555:PNPO ^@ http://purl.uniprot.org/uniprot/A0A096P410 ^@ Function|||Similarity ^@ Belongs to the pyridoxamine 5'-phosphate oxidase family.|||Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). http://togogenome.org/gene/9555:TLX3 ^@ http://purl.uniprot.org/uniprot/A0A096NCH0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:USP2 ^@ http://purl.uniprot.org/uniprot/A0A096NFG7|||http://purl.uniprot.org/uniprot/A0A2I3LPE4 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9555:RAX2 ^@ http://purl.uniprot.org/uniprot/A0A0A0MW01 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:MGMT ^@ http://purl.uniprot.org/uniprot/A0A8I5N8Z0 ^@ Function|||Similarity ^@ Belongs to the MGMT family.|||Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. http://togogenome.org/gene/9555:IER2 ^@ http://purl.uniprot.org/uniprot/A0A0A0MUT2 ^@ Similarity ^@ Belongs to the IER family. http://togogenome.org/gene/9555:DCTN4 ^@ http://purl.uniprot.org/uniprot/A0A096MLR1|||http://purl.uniprot.org/uniprot/A0A2I3M2L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunit 4 family.|||cell cortex|||centrosome|||sarcomere|||stress fiber http://togogenome.org/gene/9555:TAC1 ^@ http://purl.uniprot.org/uniprot/A0A096NWZ1|||http://purl.uniprot.org/uniprot/A0A2I3MPB5|||http://purl.uniprot.org/uniprot/A0A8I5R1P6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tachykinin family.|||Secreted|||Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. http://togogenome.org/gene/9555:HHEX ^@ http://purl.uniprot.org/uniprot/A0A096P5M1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:ALG5 ^@ http://purl.uniprot.org/uniprot/A0A096NFD5 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/9555:CEPT1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MUX1|||http://purl.uniprot.org/uniprot/A0A8I5R0M2 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/9555:BCLAF1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LFG1 ^@ Similarity ^@ Belongs to the BCLAF1/THRAP3 family. http://togogenome.org/gene/9555:VEGFC ^@ http://purl.uniprot.org/uniprot/A0A8I5N9U2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDGF/VEGF growth factor family.|||Secreted http://togogenome.org/gene/9555:ST3GAL6 ^@ http://purl.uniprot.org/uniprot/A0A096N896|||http://purl.uniprot.org/uniprot/A0A2I3MFL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9555:CHURC1 ^@ http://purl.uniprot.org/uniprot/A0A096NVL5 ^@ Similarity ^@ Belongs to the Churchill family. http://togogenome.org/gene/9555:SRD5A3 ^@ http://purl.uniprot.org/uniprot/A0A096MVS4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).|||Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.|||Endoplasmic reticulum membrane|||Membrane|||Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. http://togogenome.org/gene/9555:SH3GL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3N846 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Membrane http://togogenome.org/gene/9555:TMEM126A ^@ http://purl.uniprot.org/uniprot/A0A096N341 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:BLOC1S6 ^@ http://purl.uniprot.org/uniprot/A0A096NM00 ^@ Function|||Similarity ^@ Belongs to the BLOC1S6 family.|||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process. http://togogenome.org/gene/9555:MFNG ^@ http://purl.uniprot.org/uniprot/A0A096NJW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9555:FLI1 ^@ http://purl.uniprot.org/uniprot/A0A096ND40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9555:CRYBB1 ^@ http://purl.uniprot.org/uniprot/A0A096NRG7 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9555:LOC101015487 ^@ http://purl.uniprot.org/uniprot/A0A2I3MAK1 ^@ Similarity|||Subunit ^@ Belongs to the GST superfamily. Theta family.|||Homodimer. http://togogenome.org/gene/9555:HSF2 ^@ http://purl.uniprot.org/uniprot/A0A096NZ03|||http://purl.uniprot.org/uniprot/A0A2I3MD35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/9555:CDKL4 ^@ http://purl.uniprot.org/uniprot/A0A096NYN5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:SLC35C2 ^@ http://purl.uniprot.org/uniprot/A0A8I5N0Y3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:CACNB3 ^@ http://purl.uniprot.org/uniprot/A0A096MXG0|||http://purl.uniprot.org/uniprot/A0A2I3MEV8|||http://purl.uniprot.org/uniprot/A0A2I3MZU9|||http://purl.uniprot.org/uniprot/A0A2I3NDU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||Cytoplasm http://togogenome.org/gene/9555:F10 ^@ http://purl.uniprot.org/uniprot/A9X172 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9555:BMX ^@ http://purl.uniprot.org/uniprot/A0A096N4L2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cytoplasm http://togogenome.org/gene/9555:UGT1A4 ^@ http://purl.uniprot.org/uniprot/Q20CL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9555:SLC25A16 ^@ http://purl.uniprot.org/uniprot/A0A096P522 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9555:LOC101015677 ^@ http://purl.uniprot.org/uniprot/A0A8I5NQ50 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:LIN7A ^@ http://purl.uniprot.org/uniprot/A0A096N3P6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the lin-7 family.|||Cell membrane|||Lateral cell membrane|||Membrane|||Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.|||Postsynaptic density membrane|||tight junction http://togogenome.org/gene/9555:GIPC2 ^@ http://purl.uniprot.org/uniprot/A0A096N519 ^@ Similarity ^@ Belongs to the GIPC family. http://togogenome.org/gene/9555:CCND1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NW05 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9555:SF3A1 ^@ http://purl.uniprot.org/uniprot/A0A096NJG8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:ARPC2 ^@ http://purl.uniprot.org/uniprot/A0A096NGP3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC2 family.|||Cell projection|||Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton|||synaptosome http://togogenome.org/gene/9555:FZR1 ^@ http://purl.uniprot.org/uniprot/A0A0A0MX74 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/9555:ELP6 ^@ http://purl.uniprot.org/uniprot/A0A096NWB2 ^@ Similarity ^@ Belongs to the ELP6 family. http://togogenome.org/gene/9555:CLDN24 ^@ http://purl.uniprot.org/uniprot/A0A096MLW2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9555:SMIM7 ^@ http://purl.uniprot.org/uniprot/A0A8I5R0I9 ^@ Similarity ^@ Belongs to the SMIM7 family. http://togogenome.org/gene/9555:CAMK2D ^@ http://purl.uniprot.org/uniprot/A0A2I3LTB9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9555:FAM126A ^@ http://purl.uniprot.org/uniprot/A0A096NGN0|||http://purl.uniprot.org/uniprot/A0A2I3LII1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Hyccin family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/9555:SHANK1 ^@ http://purl.uniprot.org/uniprot/A0A8I5P440 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Postsynaptic density http://togogenome.org/gene/9555:ELOVL2 ^@ http://purl.uniprot.org/uniprot/A0A096NKX3|||http://purl.uniprot.org/uniprot/A0A8I5N7Z4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Belongs to the ELO family. ELOVL2 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Membrane|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9555:HMOX2 ^@ http://purl.uniprot.org/uniprot/A0A096NLF2 ^@ Similarity ^@ Belongs to the heme oxygenase family. http://togogenome.org/gene/9555:ATP5MC3 ^@ http://purl.uniprot.org/uniprot/A0A2I3MXZ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/9555:KIF6 ^@ http://purl.uniprot.org/uniprot/A0A096NHZ9|||http://purl.uniprot.org/uniprot/A0A2I3LQJ5|||http://purl.uniprot.org/uniprot/A0A2I3LQU8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9555:MAL2 ^@ http://purl.uniprot.org/uniprot/A0A096NG18 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:LGI2 ^@ http://purl.uniprot.org/uniprot/A0A2I3M0P6 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9555:PTGDS ^@ http://purl.uniprot.org/uniprot/A0A096NRQ3 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9555:SLC25A30 ^@ http://purl.uniprot.org/uniprot/A0A096N7X8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9555:ARG1 ^@ http://purl.uniprot.org/uniprot/A0A096P063 ^@ Cofactor|||Similarity ^@ Belongs to the arginase family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9555:TASOR2 ^@ http://purl.uniprot.org/uniprot/A0A096P3B8|||http://purl.uniprot.org/uniprot/A0A2I3NAW8|||http://purl.uniprot.org/uniprot/A0A8I5NAH1 ^@ Similarity ^@ Belongs to the TASOR family. http://togogenome.org/gene/9555:ABCC8 ^@ http://purl.uniprot.org/uniprot/A0A2I3LL00 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with KCNJ11.|||Membrane http://togogenome.org/gene/9555:CACNG7 ^@ http://purl.uniprot.org/uniprot/A9L904 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. http://togogenome.org/gene/9555:CTSD ^@ http://purl.uniprot.org/uniprot/A9L947 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Lysosome|||extracellular space http://togogenome.org/gene/9555:CADM2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LWQ7|||http://purl.uniprot.org/uniprot/A0A2I3MHM2 ^@ Similarity ^@ Belongs to the nectin family. http://togogenome.org/gene/9555:MMAA ^@ http://purl.uniprot.org/uniprot/A0A096MPN9 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. http://togogenome.org/gene/9555:FRAT1 ^@ http://purl.uniprot.org/uniprot/A0A096P5X9 ^@ Similarity ^@ Belongs to the GSK-3-binding protein family. http://togogenome.org/gene/9555:NDUFB8 ^@ http://purl.uniprot.org/uniprot/A0A8I5NAR1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB8 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:GRIK2 ^@ http://purl.uniprot.org/uniprot/A0A2I3NDZ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/9555:SLC16A12 ^@ http://purl.uniprot.org/uniprot/A0A096P5F3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:KCTD14 ^@ http://purl.uniprot.org/uniprot/A0A2I3MVT8 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9555:IL2RA ^@ http://purl.uniprot.org/uniprot/A0A096P3C7 ^@ Caution|||Function|||Subunit ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.|||Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. http://togogenome.org/gene/9555:HCAR1 ^@ http://purl.uniprot.org/uniprot/A0A096ML30 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9555:XAGE3 ^@ http://purl.uniprot.org/uniprot/A0A2I3M654 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9555:MET ^@ http://purl.uniprot.org/uniprot/A0M8R7 ^@ Activity Regulation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Autophosphorylated in response to ligand binding on Tyr-1234 and Tyr-1235 in the kinase domain leading to further phosphorylation of Tyr-1349 and Tyr-1356 in the C-terminal multifunctional docking site. Dephosphorylated by PTPRJ at Tyr-1349 and Tyr-1365. Dephosphorylated by PTPN1 and PTPN2 (By similarity).|||Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Heterodimer made of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1. Interacts when phosphorylated with downstream effectors including STAT3, PIK3R1, SRC, PCLG1, GRB2 and GAB1. Interacts with SPSB1, SPSB2 and SPSB4. Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation. Interacts with GRB10. Interacts with PTPN1 and PTPN2. Interacts with HSP90AA1 and HSP90AB1; the interaction suppresses MET kinase activity. Interacts with tensin TNS3 (By similarity). Interacts (when phosphorylated) with tensin TNS4 (via SH2 domain); the interaction increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation (By similarity).|||In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity (By similarity).|||Membrane|||O-mannosylation of IPT/TIG domains by TMEM260 is required for protein maturation. O-mannosylated residues are composed of single mannose glycans that are not elongated or modified.|||Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity).|||The beta-propeller Sema domain mediates binding to HGF.|||The kinase domain is involved in SPSB1 binding.|||Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation (By similarity). http://togogenome.org/gene/9555:VDAC1 ^@ http://purl.uniprot.org/uniprot/A0A096NAT2 ^@ Similarity ^@ Belongs to the eukaryotic mitochondrial porin family. http://togogenome.org/gene/9555:CMTM7 ^@ http://purl.uniprot.org/uniprot/A0A8I5N039 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:KCNG1 ^@ http://purl.uniprot.org/uniprot/A0A096NNN4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9555:CFL2 ^@ http://purl.uniprot.org/uniprot/A0A096NLX4 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. http://togogenome.org/gene/9555:MMS19 ^@ http://purl.uniprot.org/uniprot/A0A096P611 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MET18/MMS19 family.|||Component of the CIA complex.|||Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.|||Nucleus|||spindle http://togogenome.org/gene/9555:LOC101022082 ^@ http://purl.uniprot.org/uniprot/A0A096MT73 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Component of the 60S subunit of the ribosome.|||Cytoplasm|||In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.|||In the N-terminal section; belongs to the ubiquitin family.|||Nucleus|||Part of the 60S ribosomal subunit. http://togogenome.org/gene/9555:UROD ^@ http://purl.uniprot.org/uniprot/A0A096NWC2|||http://purl.uniprot.org/uniprot/A0A2I3MC52|||http://purl.uniprot.org/uniprot/A0A8I5N3Z0 ^@ Similarity|||Subunit ^@ Belongs to the uroporphyrinogen decarboxylase family.|||Homodimer. http://togogenome.org/gene/9555:XRN1 ^@ http://purl.uniprot.org/uniprot/A0A096MU12|||http://purl.uniprot.org/uniprot/A0A096MZS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 5'-3' exonuclease family.|||Cytoplasm http://togogenome.org/gene/9555:HSPA13 ^@ http://purl.uniprot.org/uniprot/A0A2I3N693 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 70 family.|||Binds UBQLN2.|||Endoplasmic reticulum|||Has peptide-independent ATPase activity.|||Microsome http://togogenome.org/gene/9555:DHCR7 ^@ http://purl.uniprot.org/uniprot/A0A096MM67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Membrane http://togogenome.org/gene/9555:CD8B ^@ http://purl.uniprot.org/uniprot/A0A2I3M5T5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:BBOX1 ^@ http://purl.uniprot.org/uniprot/A0A8I5N7P8 ^@ Function|||Similarity ^@ Belongs to the gamma-BBH/TMLD family.|||Catalyzes the formation of L-carnitine from gamma-butyrobetaine. http://togogenome.org/gene/9555:PPP1R11 ^@ http://purl.uniprot.org/uniprot/A0A8I5N872 ^@ Subunit ^@ Interacts with TLR2 and UBE2D2. http://togogenome.org/gene/9555:FGF6 ^@ http://purl.uniprot.org/uniprot/A0A096NPK6 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9555:GALNT17 ^@ http://purl.uniprot.org/uniprot/A0A096NFF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9555:TIMM10 ^@ http://purl.uniprot.org/uniprot/A0A096MPS6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9555:SH2D1A ^@ http://purl.uniprot.org/uniprot/A0A096NCY9 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. http://togogenome.org/gene/9555:DERL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LIA0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Membrane http://togogenome.org/gene/9555:GYS2 ^@ http://purl.uniprot.org/uniprot/A0A096N5V0 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase 3 family.|||Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. http://togogenome.org/gene/9555:NLRP12 ^@ http://purl.uniprot.org/uniprot/A9L902 ^@ Similarity ^@ Belongs to the NLRP family. http://togogenome.org/gene/9555:RBM46 ^@ http://purl.uniprot.org/uniprot/A0A096MWA6|||http://purl.uniprot.org/uniprot/A0A2I3MFU1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:ID3 ^@ http://purl.uniprot.org/uniprot/A0A8I5R933 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:CDKN1A ^@ http://purl.uniprot.org/uniprot/A0A8I5NMV2 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/9555:DPM1 ^@ http://purl.uniprot.org/uniprot/A0A2I3M5U5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum|||Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex. http://togogenome.org/gene/9555:MMP1 ^@ http://purl.uniprot.org/uniprot/A0A096MRE2 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9555:ANO10 ^@ http://purl.uniprot.org/uniprot/A0A096N625 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:CHMP7 ^@ http://purl.uniprot.org/uniprot/A0A096MZ96 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9555:STXBP5 ^@ http://purl.uniprot.org/uniprot/A0A2I3MTG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat L(2)GL family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9555:SRF ^@ http://purl.uniprot.org/uniprot/A0A096NIB8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:TUBE1 ^@ http://purl.uniprot.org/uniprot/A0A096MVT5 ^@ Similarity ^@ Belongs to the tubulin family. http://togogenome.org/gene/9555:MTERF4 ^@ http://purl.uniprot.org/uniprot/A0A096NFK9 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/9555:MTO1 ^@ http://purl.uniprot.org/uniprot/A9X188 ^@ Function|||Similarity ^@ Belongs to the MnmG family.|||Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. http://togogenome.org/gene/9555:RGS5 ^@ http://purl.uniprot.org/uniprot/A0A096MLX4 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. http://togogenome.org/gene/9555:OTX1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NC04 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:PIK3R3 ^@ http://purl.uniprot.org/uniprot/A0A096MR68 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/9555:DPT ^@ http://purl.uniprot.org/uniprot/A0A096N847 ^@ Similarity ^@ Belongs to the dermatopontin family. http://togogenome.org/gene/9555:GNG11 ^@ http://purl.uniprot.org/uniprot/A0A8I5NW67 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9555:LOC101005460 ^@ http://purl.uniprot.org/uniprot/A0A2I3M7U6 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/9555:XKR7 ^@ http://purl.uniprot.org/uniprot/A0A096NUZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9555:PRCP ^@ http://purl.uniprot.org/uniprot/A0A096N232 ^@ Similarity ^@ Belongs to the peptidase S28 family. http://togogenome.org/gene/9555:LOC101015537 ^@ http://purl.uniprot.org/uniprot/A0A2I3MCP0 ^@ Similarity ^@ Belongs to the GroES chaperonin family. http://togogenome.org/gene/9555:SUSD3 ^@ http://purl.uniprot.org/uniprot/A0A2I3LEK8|||http://purl.uniprot.org/uniprot/A0A8I5NTG3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:RPL24 ^@ http://purl.uniprot.org/uniprot/A0A096MYF2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/9555:TSC22D3 ^@ http://purl.uniprot.org/uniprot/A0A2I3MBT1 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/9555:LRRC8A ^@ http://purl.uniprot.org/uniprot/B0CM90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:LOC101004914 ^@ http://purl.uniprot.org/uniprot/A0A096N3P1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/9555:TRIM2 ^@ http://purl.uniprot.org/uniprot/A0A2I3N4T3 ^@ Similarity ^@ Belongs to the TRIM/RBCC family. http://togogenome.org/gene/9555:TSPAN31 ^@ http://purl.uniprot.org/uniprot/A0A096MKY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9555:ZNF280B ^@ http://purl.uniprot.org/uniprot/A0A096NCA4 ^@ Function|||Subcellular Location Annotation ^@ May function as a transcription factor.|||Nucleus http://togogenome.org/gene/9555:FGF4 ^@ http://purl.uniprot.org/uniprot/A0A096MM65 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9555:PRPF31 ^@ http://purl.uniprot.org/uniprot/A9L907 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP31 family.|||Cajal body http://togogenome.org/gene/9555:C16H22orf39 ^@ http://purl.uniprot.org/uniprot/A0A2I3MZ86 ^@ Similarity ^@ Belongs to the UPF0545 family. http://togogenome.org/gene/9555:NME7 ^@ http://purl.uniprot.org/uniprot/A0A2I3LTX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||cilium axoneme http://togogenome.org/gene/9555:PFDN4 ^@ http://purl.uniprot.org/uniprot/A0A2I3N630 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/9555:FECH ^@ http://purl.uniprot.org/uniprot/A0A096MPX9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferrochelatase family.|||Catalyzes the ferrous insertion into protoporphyrin IX.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:SMARCD1 ^@ http://purl.uniprot.org/uniprot/A0A096NFJ9|||http://purl.uniprot.org/uniprot/A0A2I3LY99 ^@ Similarity ^@ Belongs to the SMARCD family. http://togogenome.org/gene/9555:UBA7 ^@ http://purl.uniprot.org/uniprot/A0A096NDF9 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/9555:AKR1D1 ^@ http://purl.uniprot.org/uniprot/A0A096N3M1 ^@ Similarity|||Subunit ^@ Belongs to the aldo/keto reductase family.|||Monomer. http://togogenome.org/gene/9555:LOC108584557 ^@ http://purl.uniprot.org/uniprot/A0A2I3LF36 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9555:VPS4A ^@ http://purl.uniprot.org/uniprot/A0A096NZ10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9555:PARP16 ^@ http://purl.uniprot.org/uniprot/A0A096NMD4 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9555:HNRNPC ^@ http://purl.uniprot.org/uniprot/A0A096NNP8 ^@ Similarity ^@ Belongs to the RRM HNRPC family. RALY subfamily. http://togogenome.org/gene/9555:LETMD1 ^@ http://purl.uniprot.org/uniprot/A0A096N7Q4 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:TGFB1I1 ^@ http://purl.uniprot.org/uniprot/A0A096NHZ6|||http://purl.uniprot.org/uniprot/A0A8I5R2N0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the paxillin family.|||Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways.|||Nucleus matrix|||The LD (leucine and aspartate-rich) motif 3 mediates interaction with GIT1 and functions as a nuclear export signal.|||cytoskeleton|||focal adhesion http://togogenome.org/gene/9555:GPR83 ^@ http://purl.uniprot.org/uniprot/A0A8I5N331 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9555:DPF2 ^@ http://purl.uniprot.org/uniprot/A0A2I3N4S4 ^@ Similarity ^@ Belongs to the requiem/DPF family. http://togogenome.org/gene/9555:EHD2 ^@ http://purl.uniprot.org/uniprot/A0A0A0MVW7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/9555:VIM ^@ http://purl.uniprot.org/uniprot/A0A2I3MND3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9555:CARTPT ^@ http://purl.uniprot.org/uniprot/A0A8I5N2M8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CART family.|||Secreted http://togogenome.org/gene/9555:INPPL1 ^@ http://purl.uniprot.org/uniprot/A0A096MSZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Basal cell membrane|||Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.|||Membrane|||Nucleus speckle|||filopodium|||lamellipodium|||spindle pole http://togogenome.org/gene/9555:CTC1 ^@ http://purl.uniprot.org/uniprot/A0A096P2T9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CTC1 family.|||Nucleus|||telomere http://togogenome.org/gene/9555:TMEM168 ^@ http://purl.uniprot.org/uniprot/A0A096NEZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM168 family.|||Membrane|||Nucleus membrane http://togogenome.org/gene/9555:MAT1A ^@ http://purl.uniprot.org/uniprot/A0A096P4G0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/9555:PDK4 ^@ http://purl.uniprot.org/uniprot/A0A096NGM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9555:C7 ^@ http://purl.uniprot.org/uniprot/A0A8I5R1R3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9555:B4GALT6 ^@ http://purl.uniprot.org/uniprot/A0A096MU36 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9555:RTCA ^@ http://purl.uniprot.org/uniprot/A0A096MT18 ^@ Function|||Similarity ^@ Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.|||Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. http://togogenome.org/gene/9555:GSDMD ^@ http://purl.uniprot.org/uniprot/A0A2I3N7Z8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gasdermin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:GPM6A ^@ http://purl.uniprot.org/uniprot/A0A096N533|||http://purl.uniprot.org/uniprot/A0A8I5MVU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/9555:MAPT ^@ http://purl.uniprot.org/uniprot/A0A2I3LEF7|||http://purl.uniprot.org/uniprot/A0A2I3LT85|||http://purl.uniprot.org/uniprot/A0A2I3MFD5|||http://purl.uniprot.org/uniprot/A0A2I3NF13 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||axon|||cytoskeleton|||cytosol|||dendrite http://togogenome.org/gene/9555:CFAP36 ^@ http://purl.uniprot.org/uniprot/A0A096NP07 ^@ Similarity ^@ Belongs to the CFAP36 family. http://togogenome.org/gene/9555:ATP5F1E ^@ http://purl.uniprot.org/uniprot/A0A8I5N159 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ATPase epsilon family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. http://togogenome.org/gene/9555:TMOD4 ^@ http://purl.uniprot.org/uniprot/A9X195 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9555:SGPL1 ^@ http://purl.uniprot.org/uniprot/A0A096P4U4 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/9555:IMP3 ^@ http://purl.uniprot.org/uniprot/A0A096NB33 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/9555:PTH2 ^@ http://purl.uniprot.org/uniprot/A0A0A0MVF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the parathyroid hormone family.|||Secreted http://togogenome.org/gene/9555:SLC66A3 ^@ http://purl.uniprot.org/uniprot/A0A096NJ32|||http://purl.uniprot.org/uniprot/A0A2I3MNW3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:DGKA ^@ http://purl.uniprot.org/uniprot/A0A8I5NYS8 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic diacylglycerol kinase family.|||Monomer. http://togogenome.org/gene/9555:ACTR10 ^@ http://purl.uniprot.org/uniprot/A0A096NVB7|||http://purl.uniprot.org/uniprot/A0A8I5NHF6 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9555:CBFB ^@ http://purl.uniprot.org/uniprot/A0A096NJA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CBF-beta family.|||Nucleus http://togogenome.org/gene/9555:SMDT1 ^@ http://purl.uniprot.org/uniprot/A0A096N0E3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMDT1/EMRE family.|||Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.|||Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:ARPC4 ^@ http://purl.uniprot.org/uniprot/A9L8Z8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARPC4 family.|||Cell projection|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.|||cytoskeleton http://togogenome.org/gene/9555:SEC11C ^@ http://purl.uniprot.org/uniprot/A0A096N061 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Component of the signal peptidase complex.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:AP3B1 ^@ http://purl.uniprot.org/uniprot/A0A8I5N828 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes large subunit family.|||Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9555:MRPL49 ^@ http://purl.uniprot.org/uniprot/A0A096N123 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL49 family.|||Mitochondrion http://togogenome.org/gene/9555:CDK8 ^@ http://purl.uniprot.org/uniprot/A0A2I3MHU0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:HOXA13 ^@ http://purl.uniprot.org/uniprot/A9L945 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:LOC100997829 ^@ http://purl.uniprot.org/uniprot/A0A2I3MSB6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCRB/QCR7 family.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:HIGD1B ^@ http://purl.uniprot.org/uniprot/A0A8I5N5E6 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/9555:NUMBL ^@ http://purl.uniprot.org/uniprot/A0A0A0MU57 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Plays a role in the process of neurogenesis. http://togogenome.org/gene/9555:SLC23A3 ^@ http://purl.uniprot.org/uniprot/A0A096MN68|||http://purl.uniprot.org/uniprot/A0A2I3N9S5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:FBXL5 ^@ http://purl.uniprot.org/uniprot/A0A096NZG6 ^@ Subcellular Location Annotation ^@ perinuclear region http://togogenome.org/gene/9555:LOC101010708 ^@ http://purl.uniprot.org/uniprot/A0A2I3N420 ^@ Function|||Similarity ^@ Belongs to the cytochrome c oxidase subunit 6B.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. http://togogenome.org/gene/9555:RASGRP1 ^@ http://purl.uniprot.org/uniprot/A0A096NTD5 ^@ Similarity ^@ Belongs to the RASGRP family. http://togogenome.org/gene/9555:SMC2 ^@ http://purl.uniprot.org/uniprot/A0A8I5N074 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC2 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/9555:UBE2H ^@ http://purl.uniprot.org/uniprot/A0A096MX46 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9555:RICTOR ^@ http://purl.uniprot.org/uniprot/A0A096MKN5 ^@ Similarity ^@ Belongs to the RICTOR family. http://togogenome.org/gene/9555:ADRA1B ^@ http://purl.uniprot.org/uniprot/A0A8I5NAG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Membrane|||Nucleus membrane|||This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.|||caveola http://togogenome.org/gene/9555:SLC46A3 ^@ http://purl.uniprot.org/uniprot/A0A096NEN5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:DRD5 ^@ http://purl.uniprot.org/uniprot/A0A8I5NJJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:SIGMAR1 ^@ http://purl.uniprot.org/uniprot/A0A8I5R2J4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ERG2 family.|||Cell junction|||Cytoplasmic vesicle|||Endoplasmic reticulum membrane|||Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.|||Homotrimer.|||Lipid droplet|||Membrane|||Nucleus envelope|||Nucleus inner membrane|||Nucleus outer membrane|||Postsynaptic density membrane|||The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.|||Vesicle|||growth cone http://togogenome.org/gene/9555:PPM1B ^@ http://purl.uniprot.org/uniprot/A0A096N1U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PP2C family.|||Membrane|||cytosol http://togogenome.org/gene/9555:ND4 ^@ http://purl.uniprot.org/uniprot/K9MUQ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 4 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion membrane http://togogenome.org/gene/9555:AK4 ^@ http://purl.uniprot.org/uniprot/A0A096NDR4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK3 subfamily.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP/ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP/ATP hydrolysis.|||Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.|||Mitochondrion matrix|||Monomer. http://togogenome.org/gene/9555:PPP2R5E ^@ http://purl.uniprot.org/uniprot/A0A096NVK1|||http://purl.uniprot.org/uniprot/A0A2I3LIN2 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9555:IRF5 ^@ http://purl.uniprot.org/uniprot/A0A096NUE6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:PDIA3 ^@ http://purl.uniprot.org/uniprot/A9X1C0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9555:ESR1 ^@ http://purl.uniprot.org/uniprot/B6CK19 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Binds DNA as a homodimer.|||Nucleus|||The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. http://togogenome.org/gene/9555:ZDHHC5 ^@ http://purl.uniprot.org/uniprot/A0A096MZE5 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9555:TNFRSF1B ^@ http://purl.uniprot.org/uniprot/A0A096N881 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:LOC101009271 ^@ http://purl.uniprot.org/uniprot/A0A096NDZ5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL29 family. http://togogenome.org/gene/9555:GABRG1 ^@ http://purl.uniprot.org/uniprot/A0A096NZ00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9555:ISCU ^@ http://purl.uniprot.org/uniprot/A0A2I3LZQ8|||http://purl.uniprot.org/uniprot/A0A2I3M445 ^@ Function|||Similarity ^@ Belongs to the NifU family.|||Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5. Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form. May modulate NFS1 desulfurase activity in a zinc-dependent manner. Modulates the interaction between FXN and the cysteine desulfurase complex. http://togogenome.org/gene/9555:SENP1 ^@ http://purl.uniprot.org/uniprot/A0A8I5N4K4 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/9555:PRKACB ^@ http://purl.uniprot.org/uniprot/A0A096MN53 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/9555:MDFIC ^@ http://purl.uniprot.org/uniprot/A0A8I5NYZ7|||http://purl.uniprot.org/uniprot/A9RAA4 ^@ Similarity ^@ Belongs to the MDFI family. http://togogenome.org/gene/9555:GNMT ^@ http://purl.uniprot.org/uniprot/A0A096NI74 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family. http://togogenome.org/gene/9555:B4GALT3 ^@ http://purl.uniprot.org/uniprot/A0A096NCZ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9555:BCL7B ^@ http://purl.uniprot.org/uniprot/A0A096NQD2 ^@ Similarity ^@ Belongs to the BCL7 family. http://togogenome.org/gene/9555:SOX12 ^@ http://purl.uniprot.org/uniprot/A0A096N4N0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:LHFPL5 ^@ http://purl.uniprot.org/uniprot/A0A8I5R2Z3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:TRIM26 ^@ http://purl.uniprot.org/uniprot/A0A096NLR5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9555:DHRS7C ^@ http://purl.uniprot.org/uniprot/A0A096P2W6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9555:SIKE1 ^@ http://purl.uniprot.org/uniprot/A0A096MMI9 ^@ Similarity ^@ Belongs to the SIKE family. http://togogenome.org/gene/9555:FGF16 ^@ http://purl.uniprot.org/uniprot/A0A096MT75 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9555:SLC10A3 ^@ http://purl.uniprot.org/uniprot/A9CB67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/9555:MRPL16 ^@ http://purl.uniprot.org/uniprot/A0A096N4R1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/9555:TSNAX ^@ http://purl.uniprot.org/uniprot/A0A096NPK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the translin family.|||Nucleus http://togogenome.org/gene/9555:CORO1A ^@ http://purl.uniprot.org/uniprot/A0A096NHR2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat coronin family.|||Binds actin.|||Membrane|||cell cortex|||cytoskeleton|||phagosome membrane http://togogenome.org/gene/9555:SH3PXD2A ^@ http://purl.uniprot.org/uniprot/A0A2I3LJF2|||http://purl.uniprot.org/uniprot/A0A8I5NYY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SH3PXD2 family.|||Cytoplasm http://togogenome.org/gene/9555:SLC39A14 ^@ http://purl.uniprot.org/uniprot/A0A2I3MVY1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:ELF5 ^@ http://purl.uniprot.org/uniprot/A0A096N9C2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9555:FDPS ^@ http://purl.uniprot.org/uniprot/A0A2I3MV48|||http://purl.uniprot.org/uniprot/A0A8I5N5U2 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9555:PKMYT1 ^@ http://purl.uniprot.org/uniprot/A0A096NL89 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:PTOV1 ^@ http://purl.uniprot.org/uniprot/A0A0A0MWZ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activates transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation.|||Belongs to the Mediator complex subunit 25 family. PTOV1 subfamily.|||Cell membrane|||Cytoplasm|||May interact with CREBBP. Interacts with FLOT1.|||Nucleus|||perinuclear region http://togogenome.org/gene/9555:SEC63 ^@ http://purl.uniprot.org/uniprot/A0A096MVF5|||http://purl.uniprot.org/uniprot/B0CM40 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:FAM98B ^@ http://purl.uniprot.org/uniprot/A0A096NTD3 ^@ Similarity ^@ Belongs to the FAM98 family. http://togogenome.org/gene/9555:NDUFA12 ^@ http://purl.uniprot.org/uniprot/A0A096N2Y0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA12 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:MCU ^@ http://purl.uniprot.org/uniprot/A0A096P4Q7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MCU (TC 1.A.77) family.|||Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region: while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core. The inner core is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH).|||Membrane|||Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:ADH7 ^@ http://purl.uniprot.org/uniprot/A0A0A1EFV2 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/9555:ALKBH2 ^@ http://purl.uniprot.org/uniprot/A0A096MYW1 ^@ Similarity ^@ Belongs to the alkB family. http://togogenome.org/gene/9555:ALDH3A2 ^@ http://purl.uniprot.org/uniprot/A0A096P349|||http://purl.uniprot.org/uniprot/A0A2I3MS78 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9555:ZNF263 ^@ http://purl.uniprot.org/uniprot/A0A096NLB5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:ZRANB2 ^@ http://purl.uniprot.org/uniprot/A0A096MR64|||http://purl.uniprot.org/uniprot/A0A2I3MYG6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZRANB2 family.|||Nucleus|||Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection. http://togogenome.org/gene/9555:TRIM65 ^@ http://purl.uniprot.org/uniprot/A0A096NSZ4 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9555:OR51G2 ^@ http://purl.uniprot.org/uniprot/A9L8W2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:E2F3 ^@ http://purl.uniprot.org/uniprot/A0A096NL85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9555:SBK2 ^@ http://purl.uniprot.org/uniprot/A0A0A0MUM0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:CHUK ^@ http://purl.uniprot.org/uniprot/A0A096P673 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9555:NDUFA5 ^@ http://purl.uniprot.org/uniprot/A0A8I5MWK4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA5 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:P3H2 ^@ http://purl.uniprot.org/uniprot/A0A096N7I8 ^@ Similarity ^@ Belongs to the leprecan family. http://togogenome.org/gene/9555:SSBP4 ^@ http://purl.uniprot.org/uniprot/A0A0A0MUD1|||http://purl.uniprot.org/uniprot/A0A2I3N4J7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:MRPS11 ^@ http://purl.uniprot.org/uniprot/A0A096NN39 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/9555:BTD ^@ http://purl.uniprot.org/uniprot/A0A096NG45 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. http://togogenome.org/gene/9555:UBE2C ^@ http://purl.uniprot.org/uniprot/A0A2I3M056 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9555:SEMA4C ^@ http://purl.uniprot.org/uniprot/A0A096NGT0 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:LOC100999123 ^@ http://purl.uniprot.org/uniprot/A0A8I5NSH3 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9555:CSGALNACT2 ^@ http://purl.uniprot.org/uniprot/A0A096P477|||http://purl.uniprot.org/uniprot/A0A2I3M2J6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9555:RPE ^@ http://purl.uniprot.org/uniprot/A0A2I3LZZ1 ^@ Cofactor|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/9555:ASRGL1 ^@ http://purl.uniprot.org/uniprot/A0A096NDC5 ^@ Similarity|||Subunit ^@ Belongs to the Ntn-hydrolase family.|||Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer. http://togogenome.org/gene/9555:CNTFR ^@ http://purl.uniprot.org/uniprot/A0A096P1B0 ^@ Similarity ^@ Belongs to the type I cytokine receptor family. Type 3 subfamily. http://togogenome.org/gene/9555:HMGCLL1 ^@ http://purl.uniprot.org/uniprot/A0A096NJC5|||http://purl.uniprot.org/uniprot/A0A2I3NHM1 ^@ Similarity ^@ Belongs to the HMG-CoA lyase family. http://togogenome.org/gene/9555:EFNA3 ^@ http://purl.uniprot.org/uniprot/A0A2I3MY10 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:SFT2D2 ^@ http://purl.uniprot.org/uniprot/A0A096N5P2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.|||Membrane http://togogenome.org/gene/9555:IFNG ^@ http://purl.uniprot.org/uniprot/Q865Y4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II (or gamma) interferon family.|||Homodimer. Interacts with IFNGR1 (via extracellular domain); this interaction promotes IFNGR1 dimerization.|||Secreted|||Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity). http://togogenome.org/gene/9555:ACP5 ^@ http://purl.uniprot.org/uniprot/A0A0A0MTZ0 ^@ Cofactor ^@ Binds 2 iron ions per subunit. http://togogenome.org/gene/9555:RBM15B ^@ http://purl.uniprot.org/uniprot/A0A096NXR2 ^@ Similarity ^@ Belongs to the RRM Spen family. http://togogenome.org/gene/9555:GLYCTK ^@ http://purl.uniprot.org/uniprot/A0A096MYQ5 ^@ Similarity ^@ Belongs to the glycerate kinase type-2 family. http://togogenome.org/gene/9555:LOC101010538 ^@ http://purl.uniprot.org/uniprot/A0A096MPA8|||http://purl.uniprot.org/uniprot/A0A2I3M1I0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/9555:GPR137C ^@ http://purl.uniprot.org/uniprot/A0A096NV09 ^@ Subcellular Location Annotation ^@ Lysosome membrane|||Membrane http://togogenome.org/gene/9555:ACVR2B ^@ http://purl.uniprot.org/uniprot/A0A096NC93|||http://purl.uniprot.org/uniprot/A0A2I3LN25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9555:FOPNL ^@ http://purl.uniprot.org/uniprot/A0A2I3MGR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP43 family.|||centriole|||cilium basal body http://togogenome.org/gene/9555:HDDC2 ^@ http://purl.uniprot.org/uniprot/A0A096N0Y1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HDDC2 family.|||Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).|||Homodimer. http://togogenome.org/gene/9555:FGD6 ^@ http://purl.uniprot.org/uniprot/A0A096MT41 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9555:NQO2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LPX5 ^@ Similarity ^@ Belongs to the NAD(P)H dehydrogenase (quinone) family. http://togogenome.org/gene/9555:ADK ^@ http://purl.uniprot.org/uniprot/A0A096P4K0|||http://purl.uniprot.org/uniprot/A0A2I3MTX9|||http://purl.uniprot.org/uniprot/A0A8I5N2Z5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.|||Belongs to the carbohydrate kinase PfkB family.|||Binds 3 Mg(2+) ions per subunit.|||Monomer.|||Nucleus http://togogenome.org/gene/9555:MKNK1 ^@ http://purl.uniprot.org/uniprot/A0A2I3M6H3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:CNOT6L ^@ http://purl.uniprot.org/uniprot/A0A096MQN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCR4/nocturin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:SPATA6L ^@ http://purl.uniprot.org/uniprot/A0A096P1M6|||http://purl.uniprot.org/uniprot/A0A2I3MIR5 ^@ Similarity ^@ Belongs to the SPATA6 family. http://togogenome.org/gene/9555:MPP7 ^@ http://purl.uniprot.org/uniprot/A0A096P3W8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||adherens junction|||tight junction http://togogenome.org/gene/9555:DEFB1 ^@ http://purl.uniprot.org/uniprot/P61262 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta-defensin family.|||Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.|||Membrane|||Monomer. Homodimer.|||Secreted http://togogenome.org/gene/9555:CLDN18 ^@ http://purl.uniprot.org/uniprot/A0A096N1K8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9555:UGT1A9 ^@ http://purl.uniprot.org/uniprot/Q20CK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9555:VBP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MSI9|||http://purl.uniprot.org/uniprot/A0A2I3N7T7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit alpha family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/9555:OSBPL7 ^@ http://purl.uniprot.org/uniprot/A0A096P3Z8|||http://purl.uniprot.org/uniprot/A0A2I3MVF7 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9555:UBLCP1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NN04 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:ATE1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LCM8|||http://purl.uniprot.org/uniprot/A0A2I3LXR2 ^@ Function|||Similarity ^@ Belongs to the R-transferase family.|||Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. http://togogenome.org/gene/9555:MRPL30 ^@ http://purl.uniprot.org/uniprot/A0A2I3N1N3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/9555:LOC101010945 ^@ http://purl.uniprot.org/uniprot/A0A096MRS9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:ACTR3 ^@ http://purl.uniprot.org/uniprot/A0A096NFB8 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9555:BRCC3 ^@ http://purl.uniprot.org/uniprot/A0A096MXL9|||http://purl.uniprot.org/uniprot/A0A2I3NDB6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M67A family. BRCC36 subfamily.|||Binds 1 zinc ion per subunit.|||Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1 and BABAM2. Component of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Identified in a complex with SHMT2 and the other subunits of the BRISC complex. In the BRISC complex, interacts directly with ABRAXAS2. Identified in a complex with ABRAXAS2 and NUMA1. The BRISC complex interacts with the CSN complex. Component of the BRCA1/BRCA2 containing complex (BRCC), which also contains BRCA1, BRCA2, BARD1, BABAM2 and RAD51. BRCC is a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage. Interacts with BRCA1. Binds polyubiquitin. Interacts with PWWP2B. Interacts with HDAC1; this interaction is enhanced in the presence of PWWP2B.|||Cytoplasm|||Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.|||Nucleus|||spindle pole http://togogenome.org/gene/9555:PTTG1 ^@ http://purl.uniprot.org/uniprot/A0A2I3M6U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the securin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:LYRM9 ^@ http://purl.uniprot.org/uniprot/A0A8I5N8V5 ^@ Similarity ^@ Belongs to the complex I LYR family. LYRM9 subfamily. http://togogenome.org/gene/9555:PDSS1 ^@ http://purl.uniprot.org/uniprot/A0A096P3T7 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9555:SEPTIN10 ^@ http://purl.uniprot.org/uniprot/A0A096NUD2 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/9555:GNAO1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LTE8|||http://purl.uniprot.org/uniprot/A0A2I3MEU8 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9555:MBOAT7 ^@ http://purl.uniprot.org/uniprot/A9L911 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:GLIPR1L1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LHE1|||http://purl.uniprot.org/uniprot/A0A2I3MY76 ^@ Similarity ^@ Belongs to the CRISP family. http://togogenome.org/gene/9555:SYNCRIP ^@ http://purl.uniprot.org/uniprot/A0A2I3MXU2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:SNX6 ^@ http://purl.uniprot.org/uniprot/A9L946 ^@ Function|||Similarity ^@ Belongs to the sorting nexin family.|||Involved in several stages of intracellular trafficking. http://togogenome.org/gene/9555:GABRA6 ^@ http://purl.uniprot.org/uniprot/A0A8I5NDU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9555:ABCB9 ^@ http://purl.uniprot.org/uniprot/A0A2I3MK14 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:HACD4 ^@ http://purl.uniprot.org/uniprot/A0A096P1G1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:PENK ^@ http://purl.uniprot.org/uniprot/A0A096N787 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the opioid neuropeptide precursor family.|||Increases glutamate release in the striatum and decreases GABA concentration in the striatum.|||Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.|||Secreted|||chromaffin granule lumen http://togogenome.org/gene/9555:ST13 ^@ http://purl.uniprot.org/uniprot/A0A096NK96 ^@ Similarity ^@ Belongs to the FAM10 family. http://togogenome.org/gene/9555:VAMP5 ^@ http://purl.uniprot.org/uniprot/A0A096NZU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9555:LOC101014392 ^@ http://purl.uniprot.org/uniprot/A0A8I5N6K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FGGY kinase family.|||Cytoplasm http://togogenome.org/gene/9555:RIBC1 ^@ http://purl.uniprot.org/uniprot/A0A096MZR5 ^@ Similarity ^@ Belongs to the RIB43A family. http://togogenome.org/gene/9555:PMP2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NV24 ^@ Function|||Similarity|||Subunit ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||May play a role in lipid transport protein in Schwann cells. May bind cholesterol.|||Monomer. http://togogenome.org/gene/9555:HMX3 ^@ http://purl.uniprot.org/uniprot/A0A8I5NL95 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:MAGOHB ^@ http://purl.uniprot.org/uniprot/A0A2I3LDE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mago nashi family.|||Nucleus http://togogenome.org/gene/9555:NAPA ^@ http://purl.uniprot.org/uniprot/A0A0A0MX36 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/9555:ADCY6 ^@ http://purl.uniprot.org/uniprot/A0A096N5J8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/9555:IDH3B ^@ http://purl.uniprot.org/uniprot/A0A096NV81|||http://purl.uniprot.org/uniprot/A0A2I3MNR4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.|||Mitochondrion http://togogenome.org/gene/9555:TAFA1 ^@ http://purl.uniprot.org/uniprot/A0A096NR35 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/9555:ATP11A ^@ http://purl.uniprot.org/uniprot/A9X168 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9555:POP4 ^@ http://purl.uniprot.org/uniprot/A0A0A0MW32 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 1 family.|||Component of nuclear RNase P and RNase MRP.|||Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.|||nucleolus http://togogenome.org/gene/9555:PDX1 ^@ http://purl.uniprot.org/uniprot/A0A096MQW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9555:CAMK1G ^@ http://purl.uniprot.org/uniprot/A0A096NAP5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:LOC101006909 ^@ http://purl.uniprot.org/uniprot/A0A2I3MG70 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase IV family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:RGS9 ^@ http://purl.uniprot.org/uniprot/A0A2I3LF78 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:LFNG ^@ http://purl.uniprot.org/uniprot/A0A2I3MIU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9555:ANAPC1 ^@ http://purl.uniprot.org/uniprot/A0A096N2J1 ^@ Similarity ^@ Belongs to the APC1 family. http://togogenome.org/gene/9555:CDC45 ^@ http://purl.uniprot.org/uniprot/A0A2I3MEB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC45 family.|||Nucleus http://togogenome.org/gene/9555:SUCLA2 ^@ http://purl.uniprot.org/uniprot/A0A096NFT2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.|||Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.|||Mitochondrion http://togogenome.org/gene/9555:PLCB4 ^@ http://purl.uniprot.org/uniprot/A0A2I3MXW3|||http://purl.uniprot.org/uniprot/A0A2I3N1C8 ^@ Cofactor|||Function ^@ Binds 1 Ca(2+) ion per subunit.|||The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. http://togogenome.org/gene/9555:PRDX1 ^@ http://purl.uniprot.org/uniprot/A0A096NP25 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/9555:GRIA2 ^@ http://purl.uniprot.org/uniprot/A0A096MWL5|||http://purl.uniprot.org/uniprot/A0A2I3LN27|||http://purl.uniprot.org/uniprot/A0A8I5N698 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/9555:SPRYD4 ^@ http://purl.uniprot.org/uniprot/A0A096NH13 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:CHRDL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MPX9 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9555:B4GAT1 ^@ http://purl.uniprot.org/uniprot/A0A096MZ68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 49 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9555:MOGAT2 ^@ http://purl.uniprot.org/uniprot/A0A096MYA4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:LOC101019236 ^@ http://purl.uniprot.org/uniprot/A0A8I5NCQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:HYI ^@ http://purl.uniprot.org/uniprot/A0A096N0K9 ^@ Function|||Similarity ^@ Belongs to the hyi family.|||Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde). http://togogenome.org/gene/9555:COMP ^@ http://purl.uniprot.org/uniprot/A0A0A0MV46 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:AASS ^@ http://purl.uniprot.org/uniprot/A0A2I3LDB0|||http://purl.uniprot.org/uniprot/A0A2I3MDM8 ^@ Similarity ^@ In the C-terminal section; belongs to the saccharopine dehydrogenase family.|||In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/9555:MAB21L1 ^@ http://purl.uniprot.org/uniprot/A0A096MXA5 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9555:CTSV ^@ http://purl.uniprot.org/uniprot/A0A8I5NT33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9555:CHD9 ^@ http://purl.uniprot.org/uniprot/A0A096NI99 ^@ Similarity ^@ Belongs to the SNF2/RAD54 helicase family. http://togogenome.org/gene/9555:FAM168A ^@ http://purl.uniprot.org/uniprot/A0A096NAK6|||http://purl.uniprot.org/uniprot/A0A2I3MV11|||http://purl.uniprot.org/uniprot/A0A2I3NBV3 ^@ Similarity ^@ Belongs to the FAM168 family. http://togogenome.org/gene/9555:DKKL1 ^@ http://purl.uniprot.org/uniprot/A0A0A0MWQ7 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9555:FAM3C ^@ http://purl.uniprot.org/uniprot/A0A096MY87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/9555:MRAP ^@ http://purl.uniprot.org/uniprot/A0A8I5NNS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRAP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:PPP3CC ^@ http://purl.uniprot.org/uniprot/A0A096N243 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-2B subfamily. http://togogenome.org/gene/9555:SLC39A2 ^@ http://purl.uniprot.org/uniprot/A0A096NNN0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:OLR136 ^@ http://purl.uniprot.org/uniprot/A9L8Y6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:TAF7L ^@ http://purl.uniprot.org/uniprot/A0A096NBK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF7 family.|||Nucleus http://togogenome.org/gene/9555:LEF1 ^@ http://purl.uniprot.org/uniprot/A0A096NXR8|||http://purl.uniprot.org/uniprot/A0A2I3LCZ9|||http://purl.uniprot.org/uniprot/A0A2I3MGW1|||http://purl.uniprot.org/uniprot/A0A2I3NEF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCF/LEF family.|||Nucleus http://togogenome.org/gene/9555:IL23A ^@ http://purl.uniprot.org/uniprot/A0A096NH07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-6 superfamily.|||Secreted http://togogenome.org/gene/9555:LOC101011797 ^@ http://purl.uniprot.org/uniprot/A0A096NS09 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:TSC22D4 ^@ http://purl.uniprot.org/uniprot/A0A096NWL2 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/9555:TEK ^@ http://purl.uniprot.org/uniprot/A0A096P1E5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:PLA2G1B ^@ http://purl.uniprot.org/uniprot/A0A096MS22 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9555:TSPAN5 ^@ http://purl.uniprot.org/uniprot/A0A096MWH6|||http://purl.uniprot.org/uniprot/A0A8I5MZU7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:GSDME ^@ http://purl.uniprot.org/uniprot/A0A8I5N7C0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gasdermin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:LRRC7 ^@ http://purl.uniprot.org/uniprot/A0A096N713 ^@ Similarity ^@ Belongs to the LAP (LRR and PDZ) protein family. http://togogenome.org/gene/9555:SIX6 ^@ http://purl.uniprot.org/uniprot/A0A8I5N991 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:BB_R133_JSM474C8F ^@ http://purl.uniprot.org/uniprot/B0CM31 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/9555:ARL3 ^@ http://purl.uniprot.org/uniprot/A0A2I3NGP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||centrosome http://togogenome.org/gene/9555:AKAP12 ^@ http://purl.uniprot.org/uniprot/A0A2I3LMR5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:CXCR5 ^@ http://purl.uniprot.org/uniprot/A0A2I3LLZ0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9555:ETV2 ^@ http://purl.uniprot.org/uniprot/A0A0A0MWI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9555:HTR1A ^@ http://purl.uniprot.org/uniprot/A0A096MRD1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.|||Membrane|||dendrite http://togogenome.org/gene/9555:DNTTIP2 ^@ http://purl.uniprot.org/uniprot/A0A096MN52 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9555:SMG9 ^@ http://purl.uniprot.org/uniprot/A0A0A0MV12 ^@ Similarity ^@ Belongs to the SMG9 family. http://togogenome.org/gene/9555:SKP1 ^@ http://purl.uniprot.org/uniprot/A0A096MSB4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SKP1 family.|||Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit.|||Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1.|||The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. http://togogenome.org/gene/9555:WDR35 ^@ http://purl.uniprot.org/uniprot/A0A096NQ94|||http://purl.uniprot.org/uniprot/A0A2I3MP82 ^@ Function|||Subcellular Location Annotation ^@ As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking.|||centrosome|||cilium basal body http://togogenome.org/gene/9555:EXOC1 ^@ http://purl.uniprot.org/uniprot/A0A096NDS1|||http://purl.uniprot.org/uniprot/A0A2I3NDL8 ^@ Similarity ^@ Belongs to the SEC3 family. http://togogenome.org/gene/9555:PRPSAP2 ^@ http://purl.uniprot.org/uniprot/A0A096P338 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/9555:GABRB3 ^@ http://purl.uniprot.org/uniprot/A0A096NSX0|||http://purl.uniprot.org/uniprot/A0A2I3NER4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9555:STK39 ^@ http://purl.uniprot.org/uniprot/A0A8I5NIP1|||http://purl.uniprot.org/uniprot/A0A8I5P0F1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. http://togogenome.org/gene/9555:THBD ^@ http://purl.uniprot.org/uniprot/A0A8I5NG66 ^@ Caution|||Function|||Subunit ^@ Interacts with ITGAL, ITGAM and ITGB2.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. http://togogenome.org/gene/9555:OLFR651 ^@ http://purl.uniprot.org/uniprot/A9L8Z6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:IRAK1BP1 ^@ http://purl.uniprot.org/uniprot/A0A096MNS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRAK1BP1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:TMCO3 ^@ http://purl.uniprot.org/uniprot/A0A8I5NQV1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:WASF2 ^@ http://purl.uniprot.org/uniprot/A0A096MY18 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCAR/WAVE family.|||Binds actin and the Arp2/3 complex.|||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|||cytoskeleton http://togogenome.org/gene/9555:MED21 ^@ http://purl.uniprot.org/uniprot/A0A8I5NKS3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 21 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9555:PGAM2 ^@ http://purl.uniprot.org/uniprot/A0A096N3M5 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/9555:GABRP ^@ http://purl.uniprot.org/uniprot/A0A096ND13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9555:SH2B2 ^@ http://purl.uniprot.org/uniprot/A0A096NR70 ^@ Similarity ^@ Belongs to the SH2B adapter family. http://togogenome.org/gene/9555:SCN3B ^@ http://purl.uniprot.org/uniprot/A0A096N6P0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.|||Membrane|||Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. http://togogenome.org/gene/9555:YIF1B ^@ http://purl.uniprot.org/uniprot/A0A0A0MVY3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIF1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Has a role in transport between endoplasmic reticulum and Golgi.|||Membrane http://togogenome.org/gene/9555:KHDRBS3 ^@ http://purl.uniprot.org/uniprot/A0A096MKQ8|||http://purl.uniprot.org/uniprot/A0A8I5NQV7 ^@ Similarity ^@ Belongs to the KHDRBS family. http://togogenome.org/gene/9555:MAD1L1 ^@ http://purl.uniprot.org/uniprot/A0A096NSI9 ^@ Similarity ^@ Belongs to the MAD1 family. http://togogenome.org/gene/9555:HOXC10 ^@ http://purl.uniprot.org/uniprot/A0A096NAD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9555:MEF2D ^@ http://purl.uniprot.org/uniprot/A0A096MQL4|||http://purl.uniprot.org/uniprot/A0A2I3LML9|||http://purl.uniprot.org/uniprot/A0A2I3N0N0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:HOXB4 ^@ http://purl.uniprot.org/uniprot/A0A096P424 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9555:LOC101015700 ^@ http://purl.uniprot.org/uniprot/A0A8I5NXP3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase F chain family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:AP3S1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LM47|||http://purl.uniprot.org/uniprot/A0A2I3M0A3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Membrane|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. http://togogenome.org/gene/9555:LOC101017479 ^@ http://purl.uniprot.org/uniprot/A0A2I3N3L3 ^@ Similarity ^@ Belongs to the cystatin family. http://togogenome.org/gene/9555:HSCB ^@ http://purl.uniprot.org/uniprot/A0A8I5NKZ4 ^@ Similarity ^@ Belongs to the HscB family. http://togogenome.org/gene/9555:SERPINB4 ^@ http://purl.uniprot.org/uniprot/A9RA91 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9555:TNFSF14 ^@ http://purl.uniprot.org/uniprot/A0A2I3MXU9 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9555:ATL2 ^@ http://purl.uniprot.org/uniprot/A0A096N148|||http://purl.uniprot.org/uniprot/A0A2I3MLJ6|||http://purl.uniprot.org/uniprot/A0A2I3N888 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9555:TOR2A ^@ http://purl.uniprot.org/uniprot/A0A096P1Z9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ClpA/ClpB family. Torsin subfamily.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9555:EMC8 ^@ http://purl.uniprot.org/uniprot/A0A8I5N3S8 ^@ Similarity ^@ Belongs to the EMC8/EMC9 family. http://togogenome.org/gene/9555:LOC101019904 ^@ http://purl.uniprot.org/uniprot/A0A096MUE2|||http://purl.uniprot.org/uniprot/A0A2I3MCP0 ^@ Similarity ^@ Belongs to the GroES chaperonin family.|||Belongs to the MOB1/phocein family. http://togogenome.org/gene/9555:SFTPD ^@ http://purl.uniprot.org/uniprot/A0A096P4G4 ^@ Similarity|||Subunit ^@ Belongs to the SFTPD family.|||Oligomeric complex of 4 set of homotrimers. http://togogenome.org/gene/9555:NME9 ^@ http://purl.uniprot.org/uniprot/A0A096NS21 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9555:IQCD ^@ http://purl.uniprot.org/uniprot/A0A096N356 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC10 family.|||Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.|||flagellum axoneme http://togogenome.org/gene/9555:GPR146 ^@ http://purl.uniprot.org/uniprot/A0A096MLI7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9555:DNAJA2 ^@ http://purl.uniprot.org/uniprot/A0A096NI29 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:HIGD2A ^@ http://purl.uniprot.org/uniprot/A0A8I5MWD5 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/9555:CNNM4 ^@ http://purl.uniprot.org/uniprot/A0A096NGR9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ACDP family.|||Cell membrane|||Membrane|||Metal transporter. http://togogenome.org/gene/9555:KCNC4 ^@ http://purl.uniprot.org/uniprot/A0A096NAU8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9555:HIST1H3A ^@ http://purl.uniprot.org/uniprot/A9RA98 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:CLCC1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LJM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel MCLC family.|||Membrane http://togogenome.org/gene/9555:TMX2 ^@ http://purl.uniprot.org/uniprot/A0A096N8F9 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain.|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9555:MSX2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NEN7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:SEMA6A ^@ http://purl.uniprot.org/uniprot/A0A096NEJ4|||http://purl.uniprot.org/uniprot/A0A2I3MG83|||http://purl.uniprot.org/uniprot/A0A2I3MYZ1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:LIMK1 ^@ http://purl.uniprot.org/uniprot/A0A2I3N7Q7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. http://togogenome.org/gene/9555:PARP6 ^@ http://purl.uniprot.org/uniprot/A0A096NMM3 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9555:PTPN4 ^@ http://purl.uniprot.org/uniprot/A0A096MX43 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||May act at junctions between the membrane and the cytoskeleton.|||cytoskeleton http://togogenome.org/gene/9555:GART ^@ http://purl.uniprot.org/uniprot/A9CB00 ^@ Similarity ^@ In the C-terminal section; belongs to the GART family.|||In the N-terminal section; belongs to the GARS family.|||In the central section; belongs to the AIR synthase family. http://togogenome.org/gene/9555:FOXA1 ^@ http://purl.uniprot.org/uniprot/A0A8I5N3T8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:RAB27B ^@ http://purl.uniprot.org/uniprot/A0A096N186 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/9555:NDUFB5 ^@ http://purl.uniprot.org/uniprot/A0A096N104|||http://purl.uniprot.org/uniprot/A0A2I3MUZ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB5 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:LARS2 ^@ http://purl.uniprot.org/uniprot/A0A096MSM0 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9555:FAM110B ^@ http://purl.uniprot.org/uniprot/A0A096N6K3 ^@ Similarity ^@ Belongs to the FAM110 family. http://togogenome.org/gene/9555:TMEM244 ^@ http://purl.uniprot.org/uniprot/A0A096P075 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:COPS7B ^@ http://purl.uniprot.org/uniprot/A0A096NA46 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:CDC42BPG ^@ http://purl.uniprot.org/uniprot/B0CM68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.|||Cytoplasm http://togogenome.org/gene/9555:ODF1 ^@ http://purl.uniprot.org/uniprot/A0A096NQB7 ^@ Function ^@ Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. http://togogenome.org/gene/9555:LRRC42 ^@ http://purl.uniprot.org/uniprot/A0A096NY66 ^@ Similarity ^@ Belongs to the LRRC42 family. http://togogenome.org/gene/9555:TTC9 ^@ http://purl.uniprot.org/uniprot/A0A096NVV9 ^@ Similarity ^@ Belongs to the TTC9 family. http://togogenome.org/gene/9555:LOC103883547 ^@ http://purl.uniprot.org/uniprot/A0A096N7J3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:CRYGS ^@ http://purl.uniprot.org/uniprot/A0A096NCK3 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9555:LOC101008579 ^@ http://purl.uniprot.org/uniprot/G4XXN9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space|||Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. http://togogenome.org/gene/9555:CMTM1 ^@ http://purl.uniprot.org/uniprot/A0A8I5RA15 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:UGT1A10B ^@ http://purl.uniprot.org/uniprot/Q20CK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9555:NTNG1 ^@ http://purl.uniprot.org/uniprot/A0A096NQ63|||http://purl.uniprot.org/uniprot/A0A096P019|||http://purl.uniprot.org/uniprot/A0A2I3MS97|||http://purl.uniprot.org/uniprot/A0A2I3N5X7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:PTGDR ^@ http://purl.uniprot.org/uniprot/A0A096NV01 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9555:KCTD6 ^@ http://purl.uniprot.org/uniprot/A0A2I3LFW4 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9555:FOXI1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MWV6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:ALDH18A1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MB40 ^@ Similarity ^@ In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.|||In the N-terminal section; belongs to the glutamate 5-kinase family. http://togogenome.org/gene/9555:ATG2A ^@ http://purl.uniprot.org/uniprot/B0CM70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG2 family.|||Endoplasmic reticulum membrane|||Lipid droplet|||Preautophagosomal structure membrane http://togogenome.org/gene/9555:ATP2C1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LCV7|||http://purl.uniprot.org/uniprot/A0A2I3NGH1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:ISCA1 ^@ http://purl.uniprot.org/uniprot/A0A8I5MUJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HesB/IscA family.|||Mitochondrion http://togogenome.org/gene/9555:LAMP3 ^@ http://purl.uniprot.org/uniprot/A0A2I3MXM1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9555:CRYZ ^@ http://purl.uniprot.org/uniprot/A0A096N712 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/9555:SYCE1L ^@ http://purl.uniprot.org/uniprot/A0A096MNE9 ^@ Similarity ^@ Belongs to the SYCE family. http://togogenome.org/gene/9555:AP3M2 ^@ http://purl.uniprot.org/uniprot/A0A096N1P7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus http://togogenome.org/gene/9555:TMEM9B ^@ http://purl.uniprot.org/uniprot/A0A8I5N894 ^@ Similarity ^@ Belongs to the TMEM9 family. http://togogenome.org/gene/9555:DNASE1L3 ^@ http://purl.uniprot.org/uniprot/A0A2I3NFJ3 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/9555:TADA1 ^@ http://purl.uniprot.org/uniprot/A0A096NXJ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TADA1 family.|||Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.|||Nucleus|||Probably involved in transcriptional regulation. http://togogenome.org/gene/9555:PELI2 ^@ http://purl.uniprot.org/uniprot/A0A096NVA2 ^@ Function|||Similarity ^@ Belongs to the pellino family.|||E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. http://togogenome.org/gene/9555:SLC35E4 ^@ http://purl.uniprot.org/uniprot/A0A096NJK0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:SEMA3E ^@ http://purl.uniprot.org/uniprot/A0A096NDT4 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:DTWD2 ^@ http://purl.uniprot.org/uniprot/A0A096MMJ6 ^@ Similarity ^@ Belongs to the TDD superfamily. DTWD2 family. http://togogenome.org/gene/9555:CTSA ^@ http://purl.uniprot.org/uniprot/A0A096NX27 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/9555:ERCC4 ^@ http://purl.uniprot.org/uniprot/A0A096NLS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPF family.|||Nucleus http://togogenome.org/gene/9555:MAPKAPK2 ^@ http://purl.uniprot.org/uniprot/A0A096NF58 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:SYNGR3 ^@ http://purl.uniprot.org/uniprot/A0A2I3NI89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptogyrin family.|||Membrane http://togogenome.org/gene/9555:BRCA1 ^@ http://purl.uniprot.org/uniprot/A0A075VSV6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Chromosome|||Cytoplasm|||E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Required for FANCD2 targeting to sites of DNA damage. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator.|||Heterodimer with BARD1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the MRE11-RAD50-NBN protein (MRN) complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Interacts (via the BRCT domains) with ABRAXAS1 (phosphorylated form); this is important for recruitment to sites of DNA damage. Can form a heterotetramer with two molecules of ABRAXAS1 (phosphorylated form). Component of the BRCA1-RBBP8 complex. Interacts (via the BRCT domains) with RBBP8 ('Ser-327' phosphorylated form); the interaction ubiquitinates RBBP8, regulates CHEK1 activation, and involves RBBP8 in BRCA1-dependent G2/M checkpoint control on DNA damage. Associates with RNA polymerase II holoenzyme. Interacts with SMC1A, NELFB, DCLRE1C, CLSPN. CHEK1, CHEK2, BAP1, BRCC3, UBXN1 and PCLAF. Interacts (via BRCT domains) with BRIP1 (phosphorylated form). Interacts with FANCD2 (ubiquitinated form). Interacts with H2AX (phosphorylated on 'Ser-140'). Interacts (via the BRCT domains) with ACACA (phosphorylated form); the interaction prevents dephosphorylation of ACACA. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Interacts directly with PALB2; the interaction is essential for its function in HRR. Interacts directly with BRCA2; the interaction occurs only in the presence of PALB2 which serves as the bridging protein. Interacts (via the BRCT domains) with LMO4; the interaction represses the transcriptional activity of BRCA1. Interacts (via the BRCT domains) with CCAR2 (via N-terminus); the interaction represses the transcriptional activator activity of BRCA1. Interacts with EXD2. Interacts (via C-terminus) with DHX9; this interaction is direct and links BRCA1 to the RNA polymerase II holoenzyme.|||Nucleus http://togogenome.org/gene/9555:PHLDA3 ^@ http://purl.uniprot.org/uniprot/A0A096MLM2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:LOC101018895 ^@ http://purl.uniprot.org/uniprot/A0A1A9C8Q8 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/9555:OR51T1 ^@ http://purl.uniprot.org/uniprot/A9L8V9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:RALYL ^@ http://purl.uniprot.org/uniprot/A0A2I3MLH1|||http://purl.uniprot.org/uniprot/A0A2I3NII3 ^@ Similarity ^@ Belongs to the RRM HNRPC family. RALY subfamily. http://togogenome.org/gene/9555:C14H2orf49 ^@ http://purl.uniprot.org/uniprot/A0A096N2J3|||http://purl.uniprot.org/uniprot/A0A2I3LCI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ashwin family.|||Nucleus http://togogenome.org/gene/9555:GAP43 ^@ http://purl.uniprot.org/uniprot/A0A096N9W5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the neuromodulin family.|||Cell membrane|||Cytoplasm|||Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts (via IQ domain) with calmodulin. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.|||Membrane|||Palmitoylated. Palmitoylation is essential for plasma membrane association.|||Perikaryon|||Synapse|||This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.|||axon|||dendrite|||filopodium membrane|||growth cone membrane http://togogenome.org/gene/9555:GPER1 ^@ http://purl.uniprot.org/uniprot/A0A096N0M3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:HNRNPD ^@ http://purl.uniprot.org/uniprot/A0A096NF21|||http://purl.uniprot.org/uniprot/A0A096NXS2|||http://purl.uniprot.org/uniprot/A0A8I5NM32 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9555:SUB1 ^@ http://purl.uniprot.org/uniprot/A0A096N701 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transcriptional coactivator PC4 family.|||General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).|||Homodimer. Interacts with CSTF2.|||Nucleus http://togogenome.org/gene/9555:CSRNP2 ^@ http://purl.uniprot.org/uniprot/A0A096NAP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AXUD1 family.|||Nucleus http://togogenome.org/gene/9555:LOC101015671 ^@ http://purl.uniprot.org/uniprot/A0A096NGE3|||http://purl.uniprot.org/uniprot/A0A2I3N058 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/9555:TBX18 ^@ http://purl.uniprot.org/uniprot/A0A096NF47 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9555:G6PC3 ^@ http://purl.uniprot.org/uniprot/A0A096P5Z5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9555:C12H11orf1 ^@ http://purl.uniprot.org/uniprot/A0A096N4B6|||http://purl.uniprot.org/uniprot/A0A2I3MEU0 ^@ Function|||Subcellular Location Annotation ^@ Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.|||cilium axoneme http://togogenome.org/gene/9555:TERF2IP ^@ http://purl.uniprot.org/uniprot/A0A096N3N2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.|||Belongs to the RAP1 family.|||Homodimer.|||Nucleus|||telomere http://togogenome.org/gene/9555:RPLP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MNA4 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/9555:HSD17B12 ^@ http://purl.uniprot.org/uniprot/A0A096N4Y8 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9555:SYT14 ^@ http://purl.uniprot.org/uniprot/A0A096N406|||http://purl.uniprot.org/uniprot/A0A2I3LFY7|||http://purl.uniprot.org/uniprot/A0A2I3MSI3|||http://purl.uniprot.org/uniprot/A0A2I3NFX6 ^@ Similarity ^@ Belongs to the synaptotagmin family. http://togogenome.org/gene/9555:DCTN1 ^@ http://purl.uniprot.org/uniprot/A0A096NGM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin 150 kDa subunit family.|||cell cortex|||cytoskeleton http://togogenome.org/gene/9555:PARP14 ^@ http://purl.uniprot.org/uniprot/A0A096MZ42 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9555:ADAM17 ^@ http://purl.uniprot.org/uniprot/A0A096NIW3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:NUDC ^@ http://purl.uniprot.org/uniprot/A0A2I3LSQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nudC family.|||Midbody|||spindle http://togogenome.org/gene/9555:SEMA6D ^@ http://purl.uniprot.org/uniprot/A0A2I3MIW5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:CDH6 ^@ http://purl.uniprot.org/uniprot/A0A096MV12 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:C8H8orf37 ^@ http://purl.uniprot.org/uniprot/A0A8I5NK56 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in photoreceptor outer segment disk morphogenesis.|||Photoreceptor inner segment http://togogenome.org/gene/9555:NIF3L1 ^@ http://purl.uniprot.org/uniprot/A0A096N0A0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family.|||Cytoplasm|||Homodimer. Interacts with COPS2. Interacts with THOC7.|||May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.|||Nucleus http://togogenome.org/gene/9555:TET3 ^@ http://purl.uniprot.org/uniprot/A0A096NFM8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TET family.|||Binds 1 Fe(2+) ion per subunit.|||Chromosome|||Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.|||The zinc ions have a structural role. http://togogenome.org/gene/9555:HMGB1 ^@ http://purl.uniprot.org/uniprot/A9RA84 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated on multiple sites upon stimulation with LPS (By similarity). Acetylation on lysine residues in the nuclear localization signals (NLS 1 and NLS 2) leads to cytoplasmic localization and subsequent secretion. Acetylation on Lys-3 results in preferential binding to DNA ends and impairs DNA bending activity (By similarity).|||Belongs to the HMGB family.|||Cell membrane|||Chromosome|||Cytoplasm|||Endoplasmic reticulum-Golgi intermediate compartment|||Endosome|||Forms covalent cross-links mediated by transglutaminase TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers.|||HMG box 2 mediates pro-inflammatory cytokine-stimulating activity and binding to TLR4. However, not involved in mediating immunogenic activity in the context of apoptosis-induced immune tolerance.|||In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation. Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury. In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy. Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages.|||In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization. Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM. Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors. Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE. Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10. Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12. TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2. In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes. Contributes to tumor proliferation by association with ACER/RAGE. Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex. Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B cell responses to endogenous TLR9 ligands through a B-cell receptor (BCR)-dependent and ACER/RAGE-independent mechanism. Inhibits phagocytosis of apoptotic cells by macrophages; the function is dependent on poly-ADP-ribosylation and involves binding to phosphatidylserine on the cell surface of apoptotic cells. In adaptive immunity may be involved in enhancing immunity through activation of effector T-cells and suppression of regulatory T (TReg) cells. In contrast, without implicating effector or regulatory T-cells, required for tumor infiltration and activation of T-cells expressing the lymphotoxin LTA:LTB heterotrimer thus promoting tumor malignant progression. Also reported to limit proliferation of T-cells. Released HMGB1:nucleosome complexes formed during apoptosis can signal through TLR2 to induce cytokine production. Involved in induction of immunological tolerance by apoptotic cells; its pro-inflammatory activities when released by apoptotic cells are neutralized by reactive oxygen species (ROS)-dependent oxidation specifically on Cys-106. During macrophage activation by activated lymphocyte-derived self apoptotic DNA (ALD-DNA) promotes recruitment of ALD-DNA to endosomes.|||In vitro cleavage by CASP1 is liberating a HMG box 1-containing peptide which may mediate immunogenic activity; the peptide antagonizes apoptosis-induced immune tolerance. Can be proteolytically cleaved by a thrombin:thrombomodulin complex; reduces binding to heparin and pro-inflammatory activities (By similarity).|||Interacts (fully reduced HMGB1) with CXCL12; probably in a 1:2 ratio involving two molecules of CXCL12, each interacting with one HMG box of HMGB1; inhibited by Glycyrrhizin. Associates with the TLR4:LY96 receptor complex. Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. Interacts (in cytoplasm upon starvation) with BECN1; inhibits the interaction of BECN1 and BCL2 leading to promotion of autophagy. Interacts with KPNA1; involved in nuclear import. Interacts with SREBF1, TLR2, TLR4, TLR9, PTPRZ1, APEX1, FEN1, POLB, TERT. Interacts with IL1B, AGER, MSH2, XPA, XPC, HNF1A, TP53. Interacts with CD24; the probable CD24:SIGLEC10 complex is proposed to inhibit HGMB1-mediated tissue damage immune response. Interacts with THBD; prevents HGMB1 interaction with ACER/RAGE and inhibits HGMB1 pro-inflammatory activity. Interacts with HAVCR2; impairs HMGB1 binding to B-DNA and likely HMGB1-mediated innate immune response. Interacts with XPO1; mediating nuclear export. Interacts with receptor RAGE/AGER (By similarity).|||Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance. Has proangiogenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide. Bound to RAGE mediates signaling for neuronal outgrowth. May play a role in accumulation of expanded polyglutamine (polyQ) proteins.|||Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity. May be involved in nucleotide excision repair (NER), mismatch repair (MMR) and base excision repair (BER) pathways, and double strand break repair such as non-homologous end joining (NHEJ). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). In vitro can displace histone H1 from highly bent DNA. Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding. Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities. Facilitates binding of TP53 to DNA. May be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1. Can modulate the activity of the telomerase complex and may be involved in telomere maintenance.|||Nucleus|||Phosphorylated at serine residues. Phosphorylation in both NLS regions is required for cytoplasmic translocation followed by secretion.|||Poly-ADP-ribosylated by PARP1 when secreted following stimulation with LPS (By similarity).|||Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-106 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities in various cellular compartments: 1- fully reduced HMGB1 (HMGB1C23hC45hC106h), 2- disulfide HMGB1 (HMGB1C23-C45C106h) and 3- sulfonyl HMGB1 (HMGB1C23soC45soC106so).|||Secreted|||The acidic C-terminal domain forms a flexible structure which can reversibly interact intramolecularily with the HMG boxes and modulate binding to DNA and other proteins. http://togogenome.org/gene/9555:GATA2 ^@ http://purl.uniprot.org/uniprot/A0A096N3W4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:MOB1A ^@ http://purl.uniprot.org/uniprot/A0A096NXT1 ^@ Similarity ^@ Belongs to the MOB1/phocein family. http://togogenome.org/gene/9555:HSPB8 ^@ http://purl.uniprot.org/uniprot/A0A096N1G3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Cytoplasm|||Displays temperature-dependent chaperone activity.|||Nucleus http://togogenome.org/gene/9555:PSMD9 ^@ http://purl.uniprot.org/uniprot/A0A096N8L3 ^@ Similarity ^@ Belongs to the proteasome subunit p27 family. http://togogenome.org/gene/9555:MIF ^@ http://purl.uniprot.org/uniprot/A0A2I3M5Q0 ^@ Similarity ^@ Belongs to the MIF family. http://togogenome.org/gene/9555:TTYH1 ^@ http://purl.uniprot.org/uniprot/A9L920 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tweety family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Probable chloride channel. http://togogenome.org/gene/9555:BCAT1 ^@ http://purl.uniprot.org/uniprot/A0A096NP72|||http://purl.uniprot.org/uniprot/A0A2I3LTP3|||http://purl.uniprot.org/uniprot/A0A8I5NUR8 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9555:CACYBP ^@ http://purl.uniprot.org/uniprot/A0A096N8H5 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).|||Nucleus http://togogenome.org/gene/9555:NMNAT3 ^@ http://purl.uniprot.org/uniprot/A0A096N0Z8 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/9555:KCTD19 ^@ http://purl.uniprot.org/uniprot/A0A2I3NH18 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9555:OR52B6 ^@ http://purl.uniprot.org/uniprot/A9L8Z1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9555:LEP ^@ http://purl.uniprot.org/uniprot/A0A096MW62 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the leptin family.|||Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways. May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells. Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 wich promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38. In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses. Increases CD4(+)CD25(-) T-cell proliferation and reduces autophagy during TCR (T-cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation.|||Secreted http://togogenome.org/gene/9555:CREG2 ^@ http://purl.uniprot.org/uniprot/A0A096NFM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CREG family.|||Secreted http://togogenome.org/gene/9555:TRAF3 ^@ http://purl.uniprot.org/uniprot/A0A096NJV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/9555:ONECUT2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LL97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/9555:GNG5 ^@ http://purl.uniprot.org/uniprot/A0A2I3M9L5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9555:IP6K1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LJC3 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9555:IL7R ^@ http://purl.uniprot.org/uniprot/A0A096N4Q6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 4 subfamily.|||Membrane|||Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).|||The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R. http://togogenome.org/gene/9555:SENP3 ^@ http://purl.uniprot.org/uniprot/A0A096P2Q9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C48 family.|||nucleolus http://togogenome.org/gene/9555:SLC2A13 ^@ http://purl.uniprot.org/uniprot/A0A096MUX3 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/9555:FAM174A ^@ http://purl.uniprot.org/uniprot/A0A096N9N9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM174 family.|||Membrane http://togogenome.org/gene/9555:KCTD20 ^@ http://purl.uniprot.org/uniprot/A0A2I3LR49 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:PIP4P1 ^@ http://purl.uniprot.org/uniprot/A0A096NNL4 ^@ Function|||Subcellular Location Annotation ^@ Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane|||phagosome membrane http://togogenome.org/gene/9555:SS18 ^@ http://purl.uniprot.org/uniprot/A0A2I3LW61|||http://purl.uniprot.org/uniprot/A0A8I5NPC6 ^@ Similarity ^@ Belongs to the SS18 family. http://togogenome.org/gene/9555:SRP54 ^@ http://purl.uniprot.org/uniprot/A0A2I3NHN3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. Interacts with RNPS1. Interacts with the SRP receptor subunit SRPRA.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development.|||Cytoplasm|||Endoplasmic reticulum|||Nucleus speckle|||The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.|||The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER. http://togogenome.org/gene/9555:DDX18 ^@ http://purl.uniprot.org/uniprot/A9RA86 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9555:ACTL6A ^@ http://purl.uniprot.org/uniprot/A0A096N6F7 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9555:RASGRP4 ^@ http://purl.uniprot.org/uniprot/A0A0A0MUX0 ^@ Similarity ^@ Belongs to the RASGRP family. http://togogenome.org/gene/9555:SLC11A1 ^@ http://purl.uniprot.org/uniprot/A0A096N2F1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NRAMP family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/9555:PDZK1IP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3M0I0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:GREM2 ^@ http://purl.uniprot.org/uniprot/A0A096MLY5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9555:IL17A ^@ http://purl.uniprot.org/uniprot/A0A8I5R2H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/9555:ZAR1 ^@ http://purl.uniprot.org/uniprot/A0A096NRE7 ^@ Similarity|||Subunit ^@ Belongs to the ZAR1 family.|||Interacts with YBX2. http://togogenome.org/gene/9555:NKX6-1 ^@ http://purl.uniprot.org/uniprot/A0A096NWE0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:PI4KB ^@ http://purl.uniprot.org/uniprot/A0A096MT16|||http://purl.uniprot.org/uniprot/A0A096MY00|||http://purl.uniprot.org/uniprot/A0A2I3MJ96|||http://purl.uniprot.org/uniprot/A9X1A0 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.|||Endomembrane system|||Golgi apparatus|||Golgi apparatus membrane|||Inhibited by wortmannin. Increased kinase activity upon interaction with NCS1/FREQ.|||Interacts with ARF1 and ARF3 in the Golgi complex, but not with ARF4, ARF5 or ARF6 (By similarity). Interacts with NCS1/FREQ in a calcium-independent manner. Interacts with CALN1/CABP8 and CALN2/CABP7; in a calcium-dependent manner; this interaction competes with NCS1/FREQ binding (By similarity). Interacts with ACBD3. Interacts with ARMH3, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ and SFN (By similarity). Interacts with GGA2 (via VHS domain); the interaction is important for PI4KB location at the Golgi apparatus membrane (By similarity). Interacts with ATG9A.|||Mitochondrion outer membrane|||Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity). Involved in Golgi-to-plasma membrane trafficking (By similarity). May play an important role in the inner ear development.|||Rough endoplasmic reticulum membrane http://togogenome.org/gene/9555:SLC6A11 ^@ http://purl.uniprot.org/uniprot/A0A2I3LFN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9555:MARCKS ^@ http://purl.uniprot.org/uniprot/A0A096N6A0|||http://purl.uniprot.org/uniprot/A0A8I5NF96 ^@ Similarity ^@ Belongs to the MARCKS family. http://togogenome.org/gene/9555:CPLX4 ^@ http://purl.uniprot.org/uniprot/A0A096N586 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9555:IRF3 ^@ http://purl.uniprot.org/uniprot/A0A2I3LIV3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:SYN2 ^@ http://purl.uniprot.org/uniprot/A0A096MUZ6 ^@ Similarity ^@ Belongs to the synapsin family. http://togogenome.org/gene/9555:ERGIC3 ^@ http://purl.uniprot.org/uniprot/A0A096NUN8|||http://purl.uniprot.org/uniprot/B0CM80 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/9555:NECTIN4 ^@ http://purl.uniprot.org/uniprot/A0A096ML66 ^@ Similarity ^@ Belongs to the nectin family. http://togogenome.org/gene/9555:RHO ^@ http://purl.uniprot.org/uniprot/A0A096NPF6 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Contains one covalently linked retinal chromophore.|||Membrane http://togogenome.org/gene/9555:DSCC1 ^@ http://purl.uniprot.org/uniprot/A0A096N4A1 ^@ Similarity ^@ Belongs to the DCC1 family. http://togogenome.org/gene/9555:TNFSF4 ^@ http://purl.uniprot.org/uniprot/A0A2I3LZ24|||http://purl.uniprot.org/uniprot/A0A8I5NUY7 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9555:ALDH3B1 ^@ http://purl.uniprot.org/uniprot/A0A096MKW4 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9555:SLAIN2 ^@ http://purl.uniprot.org/uniprot/A0A096NYZ9 ^@ Similarity ^@ Belongs to the SLAIN motif-containing family. http://togogenome.org/gene/9555:HOXB13 ^@ http://purl.uniprot.org/uniprot/A0A8I5R7K5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9555:EXT1 ^@ http://purl.uniprot.org/uniprot/A9X1C8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane|||Forms a homo/heterooligomeric complex with EXT2. Interacts with NDST1.|||Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity).|||Golgi apparatus membrane|||cis-Golgi network membrane http://togogenome.org/gene/9555:PLK3 ^@ http://purl.uniprot.org/uniprot/A0A2I3MXI7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. http://togogenome.org/gene/9555:EREG ^@ http://purl.uniprot.org/uniprot/A0A8I5P446 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:TMC4 ^@ http://purl.uniprot.org/uniprot/A9L910 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMC family.|||Membrane http://togogenome.org/gene/9555:NKD2 ^@ http://purl.uniprot.org/uniprot/A0A096MW93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NKD family.|||Cell autonomous antagonist of the canonical Wnt signaling pathway.|||Cell membrane|||Cytoplasm http://togogenome.org/gene/9555:LIMS1 ^@ http://purl.uniprot.org/uniprot/A0A096N4T4|||http://purl.uniprot.org/uniprot/A0A096NCD2|||http://purl.uniprot.org/uniprot/A0A2I3LUC5|||http://purl.uniprot.org/uniprot/A0A2I3N3D0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.|||Cell membrane|||Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.|||focal adhesion http://togogenome.org/gene/9555:ATXN1L ^@ http://purl.uniprot.org/uniprot/A0A096NEH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATXN1 family.|||Nucleus http://togogenome.org/gene/9555:DPYSL2 ^@ http://purl.uniprot.org/uniprot/A0A096NZ33|||http://purl.uniprot.org/uniprot/A0A2I3MEK7 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/9555:GNPDA1 ^@ http://purl.uniprot.org/uniprot/A0A096N652 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/9555:AMIGO1 ^@ http://purl.uniprot.org/uniprot/A0A096MMY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. AMIGO family.|||Membrane http://togogenome.org/gene/9555:IYD ^@ http://purl.uniprot.org/uniprot/A0A2I3M4G1 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9555:DDRGK1 ^@ http://purl.uniprot.org/uniprot/A0A096NV96 ^@ Similarity ^@ Belongs to the DDRGK1 family. http://togogenome.org/gene/9555:MEPCE ^@ http://purl.uniprot.org/uniprot/A0A096NGW6 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/9555:JPH4 ^@ http://purl.uniprot.org/uniprot/A0A096NX40 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the junctophilin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.|||Membrane http://togogenome.org/gene/9555:KCNJ13 ^@ http://purl.uniprot.org/uniprot/A0A096MY73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9555:APOC4 ^@ http://purl.uniprot.org/uniprot/A0A096P2H6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the apolipoprotein C4 family.|||May participate in lipoprotein metabolism.|||Secreted http://togogenome.org/gene/9555:LPXN ^@ http://purl.uniprot.org/uniprot/A0A2I3LS62 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the paxillin family.|||Cell membrane|||Cytoplasm|||Nucleus|||The LIM domain 3 is critical for focal adhesion targeting and the suppression of paxillin (PXN) tyrosine phosphorylation. The LIM domain 3 alone or both LIM domains 3 and 4 can mediate interaction with AR.|||Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN).|||focal adhesion|||perinuclear region|||podosome http://togogenome.org/gene/9555:HOXD13 ^@ http://purl.uniprot.org/uniprot/A0A096NPT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9555:UGT2B42 ^@ http://purl.uniprot.org/uniprot/D2SMM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9555:PRPF19 ^@ http://purl.uniprot.org/uniprot/A0A2I3LU32 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat PRP19 family.|||Homotetramer.|||Lipid droplet|||Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.|||nucleoplasm http://togogenome.org/gene/9555:TSPAN11 ^@ http://purl.uniprot.org/uniprot/A0A096N9J4|||http://purl.uniprot.org/uniprot/A0A8I5NBH9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:GPN3 ^@ http://purl.uniprot.org/uniprot/A0A2I3MY60 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.|||Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/9555:LOC101009400 ^@ http://purl.uniprot.org/uniprot/A0A096NIS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9555:DGCR6 ^@ http://purl.uniprot.org/uniprot/A0A096N6U3 ^@ Similarity ^@ Belongs to the gonadal family. http://togogenome.org/gene/9555:CDC37 ^@ http://purl.uniprot.org/uniprot/A0A0A0MX18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC37 family.|||Cytoplasm http://togogenome.org/gene/9555:FOXE3 ^@ http://purl.uniprot.org/uniprot/A0A096NSE8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:ARL9 ^@ http://purl.uniprot.org/uniprot/A0A2I3M840 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9555:ARCN1 ^@ http://purl.uniprot.org/uniprot/A0A096NCP2|||http://purl.uniprot.org/uniprot/A0A2I3NC75 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/9555:SEMG1 ^@ http://purl.uniprot.org/uniprot/A4K2M8 ^@ Similarity ^@ Belongs to the semenogelin family. http://togogenome.org/gene/9555:LOC101001060 ^@ http://purl.uniprot.org/uniprot/A0A096NAG5 ^@ Similarity ^@ Belongs to the HMGA family. http://togogenome.org/gene/9555:OST4 ^@ http://purl.uniprot.org/uniprot/A0A096MNB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:NDUFS1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MRP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I 75 kDa subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:CFLAR ^@ http://purl.uniprot.org/uniprot/A0A096N333 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9555:SDHAF3 ^@ http://purl.uniprot.org/uniprot/A0A096MU49 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I LYR family. SDHAF3 subfamily.|||Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.|||Mitochondrion matrix|||Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1. http://togogenome.org/gene/9555:MYLK2 ^@ http://purl.uniprot.org/uniprot/A0A096NV00 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.|||Cytoplasm|||May interact with centrin. http://togogenome.org/gene/9555:MINPP1 ^@ http://purl.uniprot.org/uniprot/A0A096P5A5 ^@ Similarity ^@ Belongs to the histidine acid phosphatase family. MINPP1 subfamily. http://togogenome.org/gene/9555:FGF13 ^@ http://purl.uniprot.org/uniprot/A0A096N1F8 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9555:STIM2 ^@ http://purl.uniprot.org/uniprot/A0A096NZL6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:LOC101020469 ^@ http://purl.uniprot.org/uniprot/A0A096NV07 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase IV family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:SAMM50 ^@ http://purl.uniprot.org/uniprot/A0A096NKJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAM50/omp85 family.|||Mitochondrion outer membrane http://togogenome.org/gene/9555:SPECC1L ^@ http://purl.uniprot.org/uniprot/A0A2I3MXG1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytospin-A family.|||Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.|||May interact with both microtubules and actin cytoskeleton.|||cytoskeleton|||gap junction|||spindle http://togogenome.org/gene/9555:RPS27L ^@ http://purl.uniprot.org/uniprot/A0A2I3LW23 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9555:SORCS1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LUP3 ^@ Similarity ^@ Belongs to the VPS10-related sortilin family. SORCS subfamily. http://togogenome.org/gene/9555:KLHL3 ^@ http://purl.uniprot.org/uniprot/A0A096MMK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KLHL3 family.|||cytoskeleton|||cytosol http://togogenome.org/gene/9555:MTFR1 ^@ http://purl.uniprot.org/uniprot/A0A096N8D3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission. http://togogenome.org/gene/9555:C12H11orf58 ^@ http://purl.uniprot.org/uniprot/A0A096NRX8 ^@ Similarity ^@ Belongs to the SMAP family. http://togogenome.org/gene/9555:MRPS25 ^@ http://purl.uniprot.org/uniprot/A0A2I3MNF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS25 family.|||Mitochondrion http://togogenome.org/gene/9555:HK2 ^@ http://purl.uniprot.org/uniprot/A0A096MS63 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/9555:SLC1A1 ^@ http://purl.uniprot.org/uniprot/A0A096P1M8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9555:OTC ^@ http://purl.uniprot.org/uniprot/A0A096N4P9 ^@ Similarity|||Subunit ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily.|||Homotrimer. http://togogenome.org/gene/9555:TAS2R9 ^@ http://purl.uniprot.org/uniprot/A0A8I5NEB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9555:AKAP3 ^@ http://purl.uniprot.org/uniprot/A0A096NP58 ^@ Similarity ^@ Belongs to the AKAP110 family. http://togogenome.org/gene/9555:LOC101010920 ^@ http://purl.uniprot.org/uniprot/A0A096MVT0 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/9555:TMEFF1 ^@ http://purl.uniprot.org/uniprot/A0A096P109 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:ROCK1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LC55 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by RHOA binding. Inhibited by Y-27632.|||Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.|||Cytoplasm|||Homodimer.|||Membrane|||Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. http://togogenome.org/gene/9555:TEX13A ^@ http://purl.uniprot.org/uniprot/A0A8I5R925 ^@ Similarity ^@ Belongs to the TEX13 family. http://togogenome.org/gene/9555:ALG13 ^@ http://purl.uniprot.org/uniprot/A0A2I3M1R3 ^@ Similarity ^@ Belongs to the glycosyltransferase 28 family. http://togogenome.org/gene/9555:TMEM131 ^@ http://purl.uniprot.org/uniprot/A0A096NGU6 ^@ Similarity ^@ Belongs to the TMEM131 family. http://togogenome.org/gene/9555:ESCO1 ^@ http://purl.uniprot.org/uniprot/A0A096MVE1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:UPF1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MB73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA2/NAM7 helicase family.|||Cytoplasm http://togogenome.org/gene/9555:CAMK2G ^@ http://purl.uniprot.org/uniprot/A0A096P4K7|||http://purl.uniprot.org/uniprot/A0A2I3LKN4|||http://purl.uniprot.org/uniprot/A0A2I3N097|||http://purl.uniprot.org/uniprot/A0A2I3N8S0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9555:NSG1 ^@ http://purl.uniprot.org/uniprot/A0A096NZE4 ^@ Similarity ^@ Belongs to the NSG family. http://togogenome.org/gene/9555:MRPL23 ^@ http://purl.uniprot.org/uniprot/A9L954 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/9555:WDYHV1 ^@ http://purl.uniprot.org/uniprot/A0A096N103 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NTAQ1 family.|||Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.|||Monomer. http://togogenome.org/gene/9555:ZNF408 ^@ http://purl.uniprot.org/uniprot/A0A2I3MV79 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:DNAJC24 ^@ http://purl.uniprot.org/uniprot/A0A8I5NT62 ^@ Similarity ^@ Belongs to the DPH4 family. http://togogenome.org/gene/9555:AURKB ^@ http://purl.uniprot.org/uniprot/A0A2I3MT06 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. http://togogenome.org/gene/9555:TMEM200A ^@ http://purl.uniprot.org/uniprot/A0A096NEF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM200 family.|||Membrane http://togogenome.org/gene/9555:UNC119 ^@ http://purl.uniprot.org/uniprot/A0A096P396 ^@ Similarity ^@ Belongs to the PDE6D/unc-119 family. http://togogenome.org/gene/9555:DMTF1 ^@ http://purl.uniprot.org/uniprot/A0A096NZY8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:C12H11orf49 ^@ http://purl.uniprot.org/uniprot/A0A096N7A7|||http://purl.uniprot.org/uniprot/A0A2I3LKA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSTPP1 family.|||cytoskeleton http://togogenome.org/gene/9555:APP ^@ http://purl.uniprot.org/uniprot/A0A2I3MNJ9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APP family.|||Cell membrane|||Cell surface|||Cytoplasmic vesicle|||Early endosome|||Endosome|||Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.|||Golgi apparatus|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).|||Nucleus|||Perikaryon|||Secreted|||The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.|||Vesicle|||clathrin-coated pit|||growth cone http://togogenome.org/gene/9555:COG4 ^@ http://purl.uniprot.org/uniprot/A0A2I3ML57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG4 family.|||Golgi apparatus membrane http://togogenome.org/gene/9555:DGUOK ^@ http://purl.uniprot.org/uniprot/A0A096NF31|||http://purl.uniprot.org/uniprot/A0A2I3NCN1 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/9555:TRMT2B ^@ http://purl.uniprot.org/uniprot/A0A096N3Z6|||http://purl.uniprot.org/uniprot/A0A2I3M622 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:TFDP1 ^@ http://purl.uniprot.org/uniprot/A0A096N2L4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9555:VNN1 ^@ http://purl.uniprot.org/uniprot/A0A096N5B0 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. http://togogenome.org/gene/9555:STX6 ^@ http://purl.uniprot.org/uniprot/A0A8I5N5S8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Golgi apparatus membrane http://togogenome.org/gene/9555:INPP4A ^@ http://purl.uniprot.org/uniprot/A0A2I3N529 ^@ Similarity ^@ Belongs to the inositol 3,4-bisphosphate 4-phosphatase family. http://togogenome.org/gene/9555:DDIT4 ^@ http://purl.uniprot.org/uniprot/A0A2I3MVE7 ^@ Similarity ^@ Belongs to the DDIT4 family. http://togogenome.org/gene/9555:MED11 ^@ http://purl.uniprot.org/uniprot/A0A096P2G6|||http://purl.uniprot.org/uniprot/A0A2I3LCK5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 11 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9555:S100A11 ^@ http://purl.uniprot.org/uniprot/A0A8I5NS44 ^@ Function|||Similarity|||Subunit ^@ Belongs to the S-100 family.|||Facilitates the differentiation and the cornification of keratinocytes.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9555:IDH1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NP05 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Homodimer. http://togogenome.org/gene/9555:CLDN23 ^@ http://purl.uniprot.org/uniprot/A0A8I5NV52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9555:MTMR1 ^@ http://purl.uniprot.org/uniprot/A0A096MQ45|||http://purl.uniprot.org/uniprot/A0A8I5QZI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/9555:ADTRP ^@ http://purl.uniprot.org/uniprot/A0A2I3N3A2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIG1 family.|||Membrane http://togogenome.org/gene/9555:EIF2B4 ^@ http://purl.uniprot.org/uniprot/A0A2I3MF81 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/9555:VXN ^@ http://purl.uniprot.org/uniprot/A0A8I5N4Y5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vexin family.|||Cell membrane|||Membrane|||Nucleus http://togogenome.org/gene/9555:ZDHHC3 ^@ http://purl.uniprot.org/uniprot/A0A2I3N4T1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9555:LOC100998438 ^@ http://purl.uniprot.org/uniprot/A0A096NZ55 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9555:FUZ ^@ http://purl.uniprot.org/uniprot/A0A0A0MUE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fuzzy family.|||cytoskeleton http://togogenome.org/gene/9555:LOC101009235 ^@ http://purl.uniprot.org/uniprot/A0A2I3MKQ3 ^@ Subunit ^@ Monomer. http://togogenome.org/gene/9555:GNB2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MJ20 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/9555:RPL5 ^@ http://purl.uniprot.org/uniprot/A0A096N666 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL18 family.|||Cytoplasm http://togogenome.org/gene/9555:TSC22D1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NFI5|||http://purl.uniprot.org/uniprot/A0A8I5NTL0 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/9555:RBM10 ^@ http://purl.uniprot.org/uniprot/A0A096MM57|||http://purl.uniprot.org/uniprot/A0A2I3MBI0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:SLC25A21 ^@ http://purl.uniprot.org/uniprot/A0A096NUN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9555:RNPEPL1 ^@ http://purl.uniprot.org/uniprot/A0A096N2Z8 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9555:SNX17 ^@ http://purl.uniprot.org/uniprot/A0A096NW81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane|||Early endosome|||Endosome|||Membrane http://togogenome.org/gene/9555:ADM ^@ http://purl.uniprot.org/uniprot/A0A2I3LEU7|||http://purl.uniprot.org/uniprot/A0A8I5NHV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adrenomedullin family.|||Secreted http://togogenome.org/gene/9555:GOLPH3 ^@ http://purl.uniprot.org/uniprot/A0A2I3LCX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLPH3/VPS74 family.|||Golgi stack membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9555:POLR2B ^@ http://purl.uniprot.org/uniprot/A0A096NEY4 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/9555:HBE1 ^@ http://purl.uniprot.org/uniprot/A9L8Y1 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9555:SKA2 ^@ http://purl.uniprot.org/uniprot/A0A096P4V4|||http://purl.uniprot.org/uniprot/A0A2I3N9J4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SKA2 family.|||spindle http://togogenome.org/gene/9555:ABI1 ^@ http://purl.uniprot.org/uniprot/A0A096P3T8|||http://purl.uniprot.org/uniprot/A0A2I3LIG0|||http://purl.uniprot.org/uniprot/A0A2I3LPF2|||http://purl.uniprot.org/uniprot/A0A2I3MCB4|||http://purl.uniprot.org/uniprot/A0A8I5NFT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABI family.|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/9555:UNC119B ^@ http://purl.uniprot.org/uniprot/A0A096NQM7 ^@ Similarity ^@ Belongs to the PDE6D/unc-119 family. http://togogenome.org/gene/9555:TARBP2 ^@ http://purl.uniprot.org/uniprot/A0A096NGJ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TARBP2 family.|||Cytoplasm|||Nucleus|||Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.|||Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC).|||perinuclear region http://togogenome.org/gene/9555:PGM1 ^@ http://purl.uniprot.org/uniprot/A0A096NA34 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/9555:SUPT4H1 ^@ http://purl.uniprot.org/uniprot/A0A096P4U0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT4 family.|||Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.|||Nucleus http://togogenome.org/gene/9555:FNBP1 ^@ http://purl.uniprot.org/uniprot/A0A096P0G6|||http://purl.uniprot.org/uniprot/A0A2I3M667|||http://purl.uniprot.org/uniprot/A0A2I3NAQ4 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9555:MDH2 ^@ http://purl.uniprot.org/uniprot/A0A096NA99 ^@ Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 1 family.|||Homodimer. http://togogenome.org/gene/9555:STING1 ^@ http://purl.uniprot.org/uniprot/A0A096NE99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STING family.|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Mitochondrion outer membrane|||autophagosome membrane|||perinuclear region http://togogenome.org/gene/9555:TXN ^@ http://purl.uniprot.org/uniprot/A0A2I3M4A4 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/9555:PTPRD ^@ http://purl.uniprot.org/uniprot/A0A2I3MEL0 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. http://togogenome.org/gene/9555:RRM2B ^@ http://purl.uniprot.org/uniprot/A0A096N728 ^@ Cofactor|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase small chain family.|||Binds 2 iron ions per subunit. http://togogenome.org/gene/9555:HOXA3 ^@ http://purl.uniprot.org/uniprot/A9L938 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9555:POLR2D ^@ http://purl.uniprot.org/uniprot/A0A096NRL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/9555:FLT1 ^@ http://purl.uniprot.org/uniprot/A0A096N1J5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:LOC101024405 ^@ http://purl.uniprot.org/uniprot/A0A096N7J3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:ARRB1 ^@ http://purl.uniprot.org/uniprot/A0A096MN07|||http://purl.uniprot.org/uniprot/A0A096MW32 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9555:OSBPL2 ^@ http://purl.uniprot.org/uniprot/A0A096NNC7 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9555:NT5C3A ^@ http://purl.uniprot.org/uniprot/A0A096P041|||http://purl.uniprot.org/uniprot/A0A8I5N997 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrimidine 5'-nucleotidase family.|||Cytoplasm http://togogenome.org/gene/9555:CLEC16A ^@ http://purl.uniprot.org/uniprot/A0A096NLP1|||http://purl.uniprot.org/uniprot/A0A2I3LRZ0 ^@ Similarity ^@ Belongs to the CLEC16A/gop-1 family. http://togogenome.org/gene/9555:DTD2 ^@ http://purl.uniprot.org/uniprot/A0A096MNG9 ^@ Similarity ^@ Belongs to the DTD family. http://togogenome.org/gene/9555:EML6 ^@ http://purl.uniprot.org/uniprot/A0A096N6R7 ^@ Function|||Similarity ^@ Belongs to the WD repeat EMAP family.|||May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. http://togogenome.org/gene/9555:IFNK ^@ http://purl.uniprot.org/uniprot/A0A8I5N7X9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9555:LOC101024289 ^@ http://purl.uniprot.org/uniprot/A0A096P1D2 ^@ Similarity ^@ Belongs to the CTAG/PCC1 family. http://togogenome.org/gene/9555:ATP1B2 ^@ http://purl.uniprot.org/uniprot/A0A096P2R7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9555:DYNLRB1 ^@ http://purl.uniprot.org/uniprot/A0A096NUS8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.|||Belongs to the GAMAD family.|||Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.|||cytoskeleton http://togogenome.org/gene/9555:NCOA2 ^@ http://purl.uniprot.org/uniprot/A0A096NEQ6|||http://purl.uniprot.org/uniprot/A0A2I3MSV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRC/p160 nuclear receptor coactivator family.|||Nucleus http://togogenome.org/gene/9555:CPEB4 ^@ http://purl.uniprot.org/uniprot/A0A096NB21|||http://purl.uniprot.org/uniprot/A0A2I3LDK1|||http://purl.uniprot.org/uniprot/A0A2I3LRT1|||http://purl.uniprot.org/uniprot/A0A2I3LUL2 ^@ Similarity ^@ Belongs to the RRM CPEB family. http://togogenome.org/gene/9555:ASB10 ^@ http://purl.uniprot.org/uniprot/A0A2I3N427 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9555:PTPN12 ^@ http://purl.uniprot.org/uniprot/A0A2I3LV67|||http://purl.uniprot.org/uniprot/A0A8I5N4F9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.|||Cytoplasm|||Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. http://togogenome.org/gene/9555:ADA ^@ http://purl.uniprot.org/uniprot/A0A096NX92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.|||Cell junction|||Cell membrane|||Cytoplasmic vesicle lumen http://togogenome.org/gene/9555:FOXL2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NE56 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:ZACN ^@ http://purl.uniprot.org/uniprot/A0A096NT19 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:PTPN2 ^@ http://purl.uniprot.org/uniprot/A0A2I3NE51 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. http://togogenome.org/gene/9555:LOC101011665 ^@ http://purl.uniprot.org/uniprot/A0A2I3MNN3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/9555:PDK1 ^@ http://purl.uniprot.org/uniprot/A0A096NZK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9555:DNA2 ^@ http://purl.uniprot.org/uniprot/A0A096P527 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA2/NAM7 helicase family.|||Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.|||Mitochondrion|||Nucleus http://togogenome.org/gene/9555:AUH ^@ http://purl.uniprot.org/uniprot/A0A096P224|||http://purl.uniprot.org/uniprot/A0A2I3LJP3 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9555:NR0B2 ^@ http://purl.uniprot.org/uniprot/A0A096N961 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR0 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:CAPN13 ^@ http://purl.uniprot.org/uniprot/A0A096NFQ7|||http://purl.uniprot.org/uniprot/A0A2I3N1D2 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9555:KRT39 ^@ http://purl.uniprot.org/uniprot/A0A096P5J3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9555:TNFSF8 ^@ http://purl.uniprot.org/uniprot/A0A096P0S0 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9555:SPG21 ^@ http://purl.uniprot.org/uniprot/A0A096NMC6 ^@ Function|||Subunit ^@ Interacts with CD4. Interacts with ALDH16A1.|||May play a role as a negative regulatory factor in CD4-dependent T-cell activation. http://togogenome.org/gene/9555:BRPF3 ^@ http://purl.uniprot.org/uniprot/A0A096NHR7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:PCYT2 ^@ http://purl.uniprot.org/uniprot/A0A096NTK3 ^@ Similarity ^@ Belongs to the cytidylyltransferase family. http://togogenome.org/gene/9555:GCG ^@ http://purl.uniprot.org/uniprot/A0A096MTV1 ^@ Similarity ^@ Belongs to the glucagon family. http://togogenome.org/gene/9555:KIF2B ^@ http://purl.uniprot.org/uniprot/A0A8I5QZY4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9555:LOC101023297 ^@ http://purl.uniprot.org/uniprot/A0A2I3LFF3 ^@ Similarity|||Subunit ^@ Belongs to the aldo/keto reductase family.|||Monomer. http://togogenome.org/gene/9555:CALHM2 ^@ http://purl.uniprot.org/uniprot/A0A8I5P170 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9555:KCTD18 ^@ http://purl.uniprot.org/uniprot/A0A096MQT6 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9555:ATP5PF ^@ http://purl.uniprot.org/uniprot/A0A8I5R105 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ATPase subunit F6 family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.|||Mitochondrion|||Mitochondrion inner membrane http://togogenome.org/gene/9555:ESYT1 ^@ http://purl.uniprot.org/uniprot/A0A096MQX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the extended synaptotagmin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:NIPSNAP2 ^@ http://purl.uniprot.org/uniprot/A0A096NDK2|||http://purl.uniprot.org/uniprot/A0A2I3MXF9 ^@ Similarity ^@ Belongs to the NipSnap family. http://togogenome.org/gene/9555:NDUFB2 ^@ http://purl.uniprot.org/uniprot/A0A096NEV6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB2 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:JUP ^@ http://purl.uniprot.org/uniprot/A0A096P5P4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-catenin family.|||adherens junction http://togogenome.org/gene/9555:GPR107 ^@ http://purl.uniprot.org/uniprot/A0A096P0G5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:DDX41 ^@ http://purl.uniprot.org/uniprot/A0A096NDQ9 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX41 subfamily. http://togogenome.org/gene/9555:LOC101020591 ^@ http://purl.uniprot.org/uniprot/A0A2I3N5I0 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/9555:KITLG ^@ http://purl.uniprot.org/uniprot/A0A096N8B8|||http://purl.uniprot.org/uniprot/A0A8I5NSY0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCF family.|||Cytoplasm|||Homodimer, non-covalently linked.|||Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.|||Secreted|||filopodium|||lamellipodium http://togogenome.org/gene/9555:PTPRS ^@ http://purl.uniprot.org/uniprot/A0A2I3MSJ5 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. http://togogenome.org/gene/9555:ATP2B1 ^@ http://purl.uniprot.org/uniprot/A0A096MLH9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:RPGRIP1L ^@ http://purl.uniprot.org/uniprot/A0A096NIC9 ^@ Similarity ^@ Belongs to the RPGRIP1 family. http://togogenome.org/gene/9555:VAMP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MSG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9555:EBF1 ^@ http://purl.uniprot.org/uniprot/A0A2I3N9Y7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COE family.|||Nucleus http://togogenome.org/gene/9555:CCKAR ^@ http://purl.uniprot.org/uniprot/A0A096NZL4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9555:RPA1 ^@ http://purl.uniprot.org/uniprot/A0A096P2B3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.|||Belongs to the replication factor A protein 1 family.|||Component of the heterotrimeric canonical replication protein A complex (RPA).|||PML body http://togogenome.org/gene/9555:PPARA ^@ http://purl.uniprot.org/uniprot/A0A096NKS0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.|||Nucleus http://togogenome.org/gene/9555:UNG ^@ http://purl.uniprot.org/uniprot/A0A096MXZ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.|||Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.|||Mitochondrion|||Monomer. Interacts with FAM72A.|||Nucleus http://togogenome.org/gene/9555:SLC39A10 ^@ http://purl.uniprot.org/uniprot/A0A096N0A4|||http://purl.uniprot.org/uniprot/A0A8I5N737 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:ARMCX3 ^@ http://purl.uniprot.org/uniprot/A0A096NP19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eutherian X-chromosome-specific Armcx family.|||Membrane http://togogenome.org/gene/9555:MACO1 ^@ http://purl.uniprot.org/uniprot/A0A096MT58 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the macoilin family.|||Endoplasmic reticulum membrane|||Membrane|||Nucleus membrane|||Plays a role in the regulation of neuronal activity.|||Rough endoplasmic reticulum membrane http://togogenome.org/gene/9555:TMEM43 ^@ http://purl.uniprot.org/uniprot/A0A096MPI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM43 family.|||Membrane http://togogenome.org/gene/9555:ZPR1 ^@ http://purl.uniprot.org/uniprot/A9CB27 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death (By similarity).|||Belongs to the ZPR1 family.|||Cajal body|||Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Interacts (via C-terminal region) with SMN1 (via C-terminal region); the interaction occurs after treatment with serum. Interacts with elongation factor 1-alpha EEF1A1; the interaction occurs in a epidermal growth factor (EGF)-dependent manner. Interacts (via zinc fingers) with EGFR (via C-terminal cytoplasmic kinase domain); the interaction is negatively regulated in response to epidermal growth factor (EGF) stimulation and EGFR kinase activity. May also bind to the PDGFR receptor (By similarity).|||Cytoplasm|||Nucleus|||axon|||gem|||growth cone|||nucleolus|||perinuclear region http://togogenome.org/gene/9555:HIF1A ^@ http://purl.uniprot.org/uniprot/A0A2I3M5E1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus speckle http://togogenome.org/gene/9555:MUL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3M4P6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:PIH1D2 ^@ http://purl.uniprot.org/uniprot/A0A096NCI2 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/9555:ADRM1 ^@ http://purl.uniprot.org/uniprot/A0A096NNC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADRM1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:SEC13 ^@ http://purl.uniprot.org/uniprot/A0A2I3N7G8|||http://purl.uniprot.org/uniprot/A0A2I3NB56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||Lysosome membrane http://togogenome.org/gene/9555:YTHDF1 ^@ http://purl.uniprot.org/uniprot/A0A8I5QZY3 ^@ Function|||Similarity ^@ Belongs to the YTHDF family.|||Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. http://togogenome.org/gene/9555:CREBL2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MRU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. ATF subfamily.|||Nucleus http://togogenome.org/gene/9555:RPL23A ^@ http://purl.uniprot.org/uniprot/A0A096MR93 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/9555:HAMP ^@ http://purl.uniprot.org/uniprot/A0A0A0MUT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hepcidin family.|||Secreted http://togogenome.org/gene/9555:OLFM1 ^@ http://purl.uniprot.org/uniprot/A0A2I3M352 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/9555:USP49 ^@ http://purl.uniprot.org/uniprot/A8MN30 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9555:HHIP ^@ http://purl.uniprot.org/uniprot/A0A2I3MYB7 ^@ Caution|||Similarity ^@ Belongs to the HHIP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:ATP6V0C ^@ http://purl.uniprot.org/uniprot/A0A096NL63 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.|||Vacuole membrane|||clathrin-coated vesicle membrane|||synaptic vesicle membrane http://togogenome.org/gene/9555:TMEM263 ^@ http://purl.uniprot.org/uniprot/A0A8I5NS38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM263 family.|||Membrane http://togogenome.org/gene/9555:SMARCA5 ^@ http://purl.uniprot.org/uniprot/A0A2I3LRH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.|||Nucleus http://togogenome.org/gene/9555:CMTM8 ^@ http://purl.uniprot.org/uniprot/A0A096NEK4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:DCTPP1 ^@ http://purl.uniprot.org/uniprot/A0A096NMH8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Homotetramer.|||Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.|||cytosol http://togogenome.org/gene/9555:IL10 ^@ http://purl.uniprot.org/uniprot/A0A8I5NT41 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/9555:CCT6B ^@ http://purl.uniprot.org/uniprot/A0A2I3MAC6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.|||Cytoplasm http://togogenome.org/gene/9555:TBPL1 ^@ http://purl.uniprot.org/uniprot/A0A096MXD7 ^@ Similarity|||Subunit ^@ Belongs to the TBP family.|||Binds TFIIA and TFIIB. http://togogenome.org/gene/9555:PIGF ^@ http://purl.uniprot.org/uniprot/A0A2I3MUP9 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:OR52A1 ^@ http://purl.uniprot.org/uniprot/A9L8X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:GMFB ^@ http://purl.uniprot.org/uniprot/A0A2I3MS64|||http://purl.uniprot.org/uniprot/A0A2I3MY40 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. GMF subfamily. http://togogenome.org/gene/9555:LOC101018921 ^@ http://purl.uniprot.org/uniprot/A0A0A0MUN6 ^@ Function|||Similarity ^@ Belongs to the cytochrome c oxidase subunit 6B.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. http://togogenome.org/gene/9555:RSPO3 ^@ http://purl.uniprot.org/uniprot/A0A8I5NUK4 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/9555:PPP1R2C ^@ http://purl.uniprot.org/uniprot/A0A8I5R558 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 2 family. http://togogenome.org/gene/9555:TMEM116 ^@ http://purl.uniprot.org/uniprot/A0A096MU67|||http://purl.uniprot.org/uniprot/A0A2I3M906 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:CDK2AP2 ^@ http://purl.uniprot.org/uniprot/A0A096N9T2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDK2AP family.|||Nucleus http://togogenome.org/gene/9555:RSAD2 ^@ http://purl.uniprot.org/uniprot/I7A9N2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RSAD2 family.|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion inner membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9555:FGF11 ^@ http://purl.uniprot.org/uniprot/A0A096P2Q2 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9555:LOC100998223 ^@ http://purl.uniprot.org/uniprot/A0A2I3M4D5 ^@ Subcellular Location Annotation ^@ Mitochondrion intermembrane space http://togogenome.org/gene/9555:FBXO46 ^@ http://purl.uniprot.org/uniprot/A0A0A0MWI8 ^@ Function ^@ Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. http://togogenome.org/gene/9555:SPATS2L ^@ http://purl.uniprot.org/uniprot/A0A096MY28|||http://purl.uniprot.org/uniprot/A0A2I3LZP7 ^@ Similarity ^@ Belongs to the SPATS2 family. http://togogenome.org/gene/9555:SEMA3D ^@ http://purl.uniprot.org/uniprot/A0A096MZM4 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:ATRNL1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NAS9|||http://purl.uniprot.org/uniprot/A0A8I5NPZ0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:ADSS2 ^@ http://purl.uniprot.org/uniprot/A0A096N1Q4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Mitochondrion|||Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.|||Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. http://togogenome.org/gene/9555:HINT1 ^@ http://purl.uniprot.org/uniprot/A0A8I5R0N7 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/9555:CDR2 ^@ http://purl.uniprot.org/uniprot/A0A096NHC7 ^@ Similarity ^@ Belongs to the CDR2 family. http://togogenome.org/gene/9555:SPESP1 ^@ http://purl.uniprot.org/uniprot/A0A096NMH6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPESP1 family.|||Involved in fertilization ability of sperm.|||acrosome http://togogenome.org/gene/9555:MGAT2 ^@ http://purl.uniprot.org/uniprot/A0A8I5N7V0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 16 (GT16) protein family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9555:DZIP1 ^@ http://purl.uniprot.org/uniprot/A0A096NYW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DZIP C2H2-type zinc-finger protein family.|||cilium basal body http://togogenome.org/gene/9555:DUSP26 ^@ http://purl.uniprot.org/uniprot/A0A8I5NGP1 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/9555:MICAL2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MTK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mical family.|||Cytoplasm http://togogenome.org/gene/9555:TBX15 ^@ http://purl.uniprot.org/uniprot/A0A2I3N5X6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9555:F2RL2 ^@ http://purl.uniprot.org/uniprot/A0A096NP45 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9555:LNPK ^@ http://purl.uniprot.org/uniprot/A0A2I3LXI4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the lunapark family.|||Endoplasmic reticulum membrane|||Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.|||Plays a role in determining ER morphology.|||The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation. http://togogenome.org/gene/9555:AGK ^@ http://purl.uniprot.org/uniprot/A0A096NFB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AGK family.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/9555:IMPAD1 ^@ http://purl.uniprot.org/uniprot/A0A096N0F5 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/9555:MFSD11 ^@ http://purl.uniprot.org/uniprot/A0A096NT50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/9555:RGS2 ^@ http://purl.uniprot.org/uniprot/A0A2I3N5Q6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||nucleolus http://togogenome.org/gene/9555:SRP9 ^@ http://purl.uniprot.org/uniprot/A0A8I5NJY3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP9 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.|||Cytoplasm http://togogenome.org/gene/9555:RPL35 ^@ http://purl.uniprot.org/uniprot/A0A096N641 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/9555:AHR ^@ http://purl.uniprot.org/uniprot/A0A8I5NZ99 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9555:ADAMTS19 ^@ http://purl.uniprot.org/uniprot/A0A2I3MP46 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9555:GPR31 ^@ http://purl.uniprot.org/uniprot/A0A8I5NXR0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9555:AOX1 ^@ http://purl.uniprot.org/uniprot/A0A096NWB4|||http://purl.uniprot.org/uniprot/M1ZMM6 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/9555:AIF1L ^@ http://purl.uniprot.org/uniprot/A0A096P0F4 ^@ Subcellular Location Annotation ^@ ruffle membrane http://togogenome.org/gene/9555:C19H18orf32 ^@ http://purl.uniprot.org/uniprot/A0A8I5P4I8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UPF0729 family.|||Interacts with DERL1 and AMFR.|||Lipid droplet|||May activate the NF-kappa-B signaling pathway. http://togogenome.org/gene/9555:GRM2 ^@ http://purl.uniprot.org/uniprot/A0A096NYH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:TRIM27 ^@ http://purl.uniprot.org/uniprot/A0A2I3LIW4 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9555:GNRHR ^@ http://purl.uniprot.org/uniprot/A0A8I5NNU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:PHTF1 ^@ http://purl.uniprot.org/uniprot/A0A096P021|||http://purl.uniprot.org/uniprot/A0A2I3LUF0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:VPS54 ^@ http://purl.uniprot.org/uniprot/A0A096P057 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS54 family.|||trans-Golgi network http://togogenome.org/gene/9555:NIM1K ^@ http://purl.uniprot.org/uniprot/A0A096NP15 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:SSR4 ^@ http://purl.uniprot.org/uniprot/A0A096N025 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-delta family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/9555:CAPZA3 ^@ http://purl.uniprot.org/uniprot/A0A096MNB7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/9555:ANKRD34B ^@ http://purl.uniprot.org/uniprot/A0A096NE46 ^@ Similarity ^@ Belongs to the ANKRD34 family. http://togogenome.org/gene/9555:FAM167B ^@ http://purl.uniprot.org/uniprot/A0A096MWT0 ^@ Similarity ^@ Belongs to the FAM167 (SEC) family. http://togogenome.org/gene/9555:PKD2L2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LG39|||http://purl.uniprot.org/uniprot/A0A2I3MLQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the polycystin family.|||Membrane http://togogenome.org/gene/9555:STRADB ^@ http://purl.uniprot.org/uniprot/A0A096MZ18 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. http://togogenome.org/gene/9555:SUV39H1 ^@ http://purl.uniprot.org/uniprot/A0A096N1M7|||http://purl.uniprot.org/uniprot/A0A2I3LCB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.|||Nucleus|||centromere http://togogenome.org/gene/9555:COPS5 ^@ http://purl.uniprot.org/uniprot/A0A096NCR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M67A family. CSN5 subfamily.|||synaptic vesicle http://togogenome.org/gene/9555:HSP90AA1 ^@ http://purl.uniprot.org/uniprot/A0A096NJT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 90 family.|||Melanosome http://togogenome.org/gene/9555:MICOS13 ^@ http://purl.uniprot.org/uniprot/A0A0A0MVL3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic13 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:BYSL ^@ http://purl.uniprot.org/uniprot/A8MN32 ^@ Similarity ^@ Belongs to the bystin family. http://togogenome.org/gene/9555:SATB1 ^@ http://purl.uniprot.org/uniprot/A0A096N6D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/9555:NEUROD6 ^@ http://purl.uniprot.org/uniprot/A0A2I3NC11 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:UCP3 ^@ http://purl.uniprot.org/uniprot/A0A096N344 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9555:HMGCR ^@ http://purl.uniprot.org/uniprot/A0A096MMF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMG-CoA reductase family.|||Endoplasmic reticulum membrane|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9555:NRM ^@ http://purl.uniprot.org/uniprot/A0A096NLV0|||http://purl.uniprot.org/uniprot/A0A2I3N756 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nurim family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/9555:EARS2 ^@ http://purl.uniprot.org/uniprot/A0A096NHE8 ^@ Function|||Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). http://togogenome.org/gene/9555:ASB8 ^@ http://purl.uniprot.org/uniprot/A0A8I5R912 ^@ Function|||Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family.|||May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/9555:FZD3 ^@ http://purl.uniprot.org/uniprot/A0A096N2M5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:CST9 ^@ http://purl.uniprot.org/uniprot/A0A2I3LDK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cystatin family.|||Secreted http://togogenome.org/gene/9555:CCL28 ^@ http://purl.uniprot.org/uniprot/A0A096MMS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9555:SND1 ^@ http://purl.uniprot.org/uniprot/A0A2I3N9Q6 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. http://togogenome.org/gene/9555:OXSM ^@ http://purl.uniprot.org/uniprot/A0A096MP89 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.|||Mitochondrion http://togogenome.org/gene/9555:NT5E ^@ http://purl.uniprot.org/uniprot/A0A096NQ29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 5'-nucleotidase family.|||Membrane http://togogenome.org/gene/9555:UBIAD1 ^@ http://purl.uniprot.org/uniprot/A0A096NWY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family.|||Membrane http://togogenome.org/gene/9555:ATP6AP2 ^@ http://purl.uniprot.org/uniprot/A0A096MTI2 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Lysosome membrane|||Membrane|||autophagosome membrane|||clathrin-coated vesicle membrane|||dendritic spine membrane|||synaptic vesicle membrane http://togogenome.org/gene/9555:TRIM34 ^@ http://purl.uniprot.org/uniprot/A9L8Z3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:SSTR1 ^@ http://purl.uniprot.org/uniprot/A0A096MLW0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9555:PHKA2 ^@ http://purl.uniprot.org/uniprot/A0A096MP99 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.|||Belongs to the phosphorylase b kinase regulatory chain family.|||Cell membrane|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.|||Membrane|||Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. http://togogenome.org/gene/9555:ATG16L2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MFZ2 ^@ Similarity ^@ Belongs to the WD repeat ATG16 family. http://togogenome.org/gene/9555:MMP26 ^@ http://purl.uniprot.org/uniprot/A9L8W4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9555:CHRDL2 ^@ http://purl.uniprot.org/uniprot/A0A096NCH7 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9555:EFNB2 ^@ http://purl.uniprot.org/uniprot/A0A096NWS7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:DUSP7 ^@ http://purl.uniprot.org/uniprot/A0A096MP15 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9555:PHOX2A ^@ http://purl.uniprot.org/uniprot/A0A096MYH6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:PKNOX1 ^@ http://purl.uniprot.org/uniprot/A0A096NIR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/9555:VAMP3 ^@ http://purl.uniprot.org/uniprot/A0A096MT61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9555:ARRDC3 ^@ http://purl.uniprot.org/uniprot/A0A096N742 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9555:PERP ^@ http://purl.uniprot.org/uniprot/A0A096N1U0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/9555:OAZ1 ^@ http://purl.uniprot.org/uniprot/A0A0A0MX67 ^@ Similarity ^@ Belongs to the ODC antizyme family. http://togogenome.org/gene/9555:SRPRA ^@ http://purl.uniprot.org/uniprot/A0A096N4B2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding SRP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:PPIC ^@ http://purl.uniprot.org/uniprot/A0A096N4P2 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9555:DTNB ^@ http://purl.uniprot.org/uniprot/A0A096MWU9|||http://purl.uniprot.org/uniprot/A0A2I3LI21|||http://purl.uniprot.org/uniprot/A0A2I3LNV2|||http://purl.uniprot.org/uniprot/A0A2I3MC95|||http://purl.uniprot.org/uniprot/A0A2I3NBM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dystrophin family. Dystrobrevin subfamily.|||Cytoplasm http://togogenome.org/gene/9555:RAB3A ^@ http://purl.uniprot.org/uniprot/A0A0A0MWG2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/9555:PNP ^@ http://purl.uniprot.org/uniprot/A0A096NNL8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family.|||Homotrimer.|||The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. http://togogenome.org/gene/9555:AP4S1 ^@ http://purl.uniprot.org/uniprot/A0A096NXG5 ^@ Similarity ^@ Belongs to the adaptor complexes small subunit family. http://togogenome.org/gene/9555:MST1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MER4 ^@ Caution|||Similarity ^@ Belongs to the peptidase S1 family. Plasminogen subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:PPBP ^@ http://purl.uniprot.org/uniprot/A0A8I5N0B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9555:PSME3IP1 ^@ http://purl.uniprot.org/uniprot/A0A096NIQ1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:CPT1B ^@ http://purl.uniprot.org/uniprot/A0A2I3LW20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the carnitine/choline acetyltransferase family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9555:SYPL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LPU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/9555:HOXC5 ^@ http://purl.uniprot.org/uniprot/A0A8I5P2N2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9555:VAMP8 ^@ http://purl.uniprot.org/uniprot/A0A2I3MIA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9555:RITA1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MY99 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RITA family.|||Cytoplasm|||Interacts with RBPJ/RBPSUH.|||Nucleus|||Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis. http://togogenome.org/gene/9555:MUSK ^@ http://purl.uniprot.org/uniprot/A0A2I3MV38 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:TSR3 ^@ http://purl.uniprot.org/uniprot/A0A096NKP9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.|||Belongs to the TDD superfamily. TSR3 family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:OR51G1 ^@ http://purl.uniprot.org/uniprot/A9L8W3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:FOXA3 ^@ http://purl.uniprot.org/uniprot/A0A2I3NEP0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:BGLAP ^@ http://purl.uniprot.org/uniprot/A0A096N2Y6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the osteocalcin/matrix Gla protein family.|||Binds strongly to apatite and calcium.|||Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.|||Secreted http://togogenome.org/gene/9555:HOXA9 ^@ http://purl.uniprot.org/uniprot/A9L942 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/9555:SNRPA ^@ http://purl.uniprot.org/uniprot/A0A0A0MVA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM U1 A/B'' family.|||Nucleus http://togogenome.org/gene/9555:DERL3 ^@ http://purl.uniprot.org/uniprot/A0A8I5NLM0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Membrane http://togogenome.org/gene/9555:ZSCAN9 ^@ http://purl.uniprot.org/uniprot/A0A096NLJ9|||http://purl.uniprot.org/uniprot/A0A096NLK0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:TSPAN32 ^@ http://purl.uniprot.org/uniprot/A0A2I3M8S2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:OPA3 ^@ http://purl.uniprot.org/uniprot/A0A2I3M1H0 ^@ Function|||Similarity ^@ Belongs to the OPA3 family.|||May play some role in mitochondrial processes. http://togogenome.org/gene/9555:PLA2G5 ^@ http://purl.uniprot.org/uniprot/A0A096NFK6 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9555:NR2F2 ^@ http://purl.uniprot.org/uniprot/A0A2I3N4Z0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9555:PLA1A ^@ http://purl.uniprot.org/uniprot/A0A096NSF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9555:CCDC93 ^@ http://purl.uniprot.org/uniprot/A9RA87 ^@ Similarity ^@ Belongs to the CCDC93 family. http://togogenome.org/gene/9555:ELMO1 ^@ http://purl.uniprot.org/uniprot/A0A8I5N4K7|||http://purl.uniprot.org/uniprot/A0A8I5NNI3 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. http://togogenome.org/gene/9555:GLT6D1 ^@ http://purl.uniprot.org/uniprot/A0A096NRP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 6 family.|||Membrane http://togogenome.org/gene/9555:HSBP1L1 ^@ http://purl.uniprot.org/uniprot/A0A096MWZ7 ^@ Similarity ^@ Belongs to the HSBP1 family. http://togogenome.org/gene/9555:SUPT20H ^@ http://purl.uniprot.org/uniprot/A0A096N1C9|||http://purl.uniprot.org/uniprot/A0A2I3LIM1 ^@ Similarity ^@ Belongs to the SPT20 family. http://togogenome.org/gene/9555:RAF1 ^@ http://purl.uniprot.org/uniprot/A0A096NYS4|||http://purl.uniprot.org/uniprot/A0A2I3N2V3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. http://togogenome.org/gene/9555:ALG3 ^@ http://purl.uniprot.org/uniprot/A0A2I3M2K1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.|||Belongs to the glycosyltransferase 58 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:PPARGC1B ^@ http://purl.uniprot.org/uniprot/A0A096MPZ4|||http://purl.uniprot.org/uniprot/A0A2I3NHT5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:GSS ^@ http://purl.uniprot.org/uniprot/A0A096NUR3 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic GSH synthase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/9555:PPP2R2D ^@ http://purl.uniprot.org/uniprot/A0A096NSV1 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/9555:ASF1A ^@ http://purl.uniprot.org/uniprot/A0A096MSH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/9555:TACC1 ^@ http://purl.uniprot.org/uniprot/A0A096N218|||http://purl.uniprot.org/uniprot/A0A2I3NI06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACC family.|||centrosome http://togogenome.org/gene/9555:DVL3 ^@ http://purl.uniprot.org/uniprot/A0A096N204 ^@ Similarity ^@ Belongs to the DSH family. http://togogenome.org/gene/9555:GABPA ^@ http://purl.uniprot.org/uniprot/A0A096NDP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9555:TNMD ^@ http://purl.uniprot.org/uniprot/A0A096MNM5 ^@ Similarity ^@ Belongs to the chondromodulin-1 family. http://togogenome.org/gene/9555:CNDP1 ^@ http://purl.uniprot.org/uniprot/A0A096N7T7 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20A family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9555:SLC2A6 ^@ http://purl.uniprot.org/uniprot/A0A096MSW4 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/9555:CNOT7 ^@ http://purl.uniprot.org/uniprot/A0A096N6Y9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/9555:TPRKB ^@ http://purl.uniprot.org/uniprot/A0A2I3M7W6 ^@ Similarity ^@ Belongs to the CGI121/TPRKB family. http://togogenome.org/gene/9555:MTCP1 ^@ http://purl.uniprot.org/uniprot/A0A096MVK8 ^@ Similarity ^@ Belongs to the TCL1 family. http://togogenome.org/gene/9555:SH2B3 ^@ http://purl.uniprot.org/uniprot/A0A096N1G4|||http://purl.uniprot.org/uniprot/A0A2I3MXH4 ^@ Similarity ^@ Belongs to the SH2B adapter family. http://togogenome.org/gene/9555:HSD17B11 ^@ http://purl.uniprot.org/uniprot/A0A096NDG2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9555:HOXA2 ^@ http://purl.uniprot.org/uniprot/A9L937 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Proboscipedia subfamily.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/9555:BOD1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NJH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BOD1 family.|||centrosome|||kinetochore http://togogenome.org/gene/9555:EIF3D ^@ http://purl.uniprot.org/uniprot/A0A2I3MYN4 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit D family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Cytoplasm|||Phosphorylated upon DNA damage, probably by ATM or ATR.|||The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.|||mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs. http://togogenome.org/gene/9555:IFT20 ^@ http://purl.uniprot.org/uniprot/A0A2I3MCM8 ^@ Subcellular Location Annotation ^@ centriole|||cilium|||cis-Golgi network http://togogenome.org/gene/9555:LAMTOR1 ^@ http://purl.uniprot.org/uniprot/A0A2I3M6U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR1 family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/9555:SEC22C ^@ http://purl.uniprot.org/uniprot/A0A2I3NIE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||May be involved in vesicle transport between the ER and the Golgi complex.|||Membrane http://togogenome.org/gene/9555:CSNK1G1 ^@ http://purl.uniprot.org/uniprot/A0A096NMB7|||http://purl.uniprot.org/uniprot/A0A2I3LHC6|||http://purl.uniprot.org/uniprot/A0A2I3M9I7|||http://purl.uniprot.org/uniprot/A0A2I3MF58|||http://purl.uniprot.org/uniprot/A0A2I3MYY4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. http://togogenome.org/gene/9555:TMEM94 ^@ http://purl.uniprot.org/uniprot/A0A096NSV6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:USP45 ^@ http://purl.uniprot.org/uniprot/A0A096NUH6 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9555:FBXO48 ^@ http://purl.uniprot.org/uniprot/A0A096MX57 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2.|||Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1. Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway. Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation. http://togogenome.org/gene/9555:MRPL37 ^@ http://purl.uniprot.org/uniprot/A0A096N932 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9555:APLP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LNR5|||http://purl.uniprot.org/uniprot/A0A2I3NBU5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APP family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:SSBP2 ^@ http://purl.uniprot.org/uniprot/A0A096NED8|||http://purl.uniprot.org/uniprot/A0A2I3LKT0|||http://purl.uniprot.org/uniprot/A0A2I3LMK6|||http://purl.uniprot.org/uniprot/A0A2I3NE24 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:NR1I2 ^@ http://purl.uniprot.org/uniprot/A0A096NXL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9555:ARFGEF1 ^@ http://purl.uniprot.org/uniprot/A0A096MQ19 ^@ Subcellular Location Annotation ^@ Golgi apparatus|||perinuclear region http://togogenome.org/gene/9555:PROS1 ^@ http://purl.uniprot.org/uniprot/A0A096MT68 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:FERMT3 ^@ http://purl.uniprot.org/uniprot/A0A096NFX2 ^@ Similarity ^@ Belongs to the kindlin family. http://togogenome.org/gene/9555:ZIC4 ^@ http://purl.uniprot.org/uniprot/A0A096N2D8 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/9555:KIF16B ^@ http://purl.uniprot.org/uniprot/A0A2I3MUS4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9555:RAB39B ^@ http://purl.uniprot.org/uniprot/A0A096MPB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:MDH1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MVX8 ^@ Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 2 family.|||Homodimer. http://togogenome.org/gene/9555:NDUFB11 ^@ http://purl.uniprot.org/uniprot/A0A096NPJ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB11 subunit family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:CPNE5 ^@ http://purl.uniprot.org/uniprot/A0A096NHT0|||http://purl.uniprot.org/uniprot/A0A2I3N9K1 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9555:LOC101009578 ^@ http://purl.uniprot.org/uniprot/A0A096NB99 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:IPO7 ^@ http://purl.uniprot.org/uniprot/A0A096MTM4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:FAM133A ^@ http://purl.uniprot.org/uniprot/A0A096MLT9 ^@ Similarity ^@ Belongs to the FAM133 family. http://togogenome.org/gene/9555:ALDOB ^@ http://purl.uniprot.org/uniprot/A0A096P102 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/9555:SCD ^@ http://purl.uniprot.org/uniprot/A0A8I5N0F1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Membrane|||The histidine box domains are involved in binding the catalytic metal ions. http://togogenome.org/gene/9555:FCER1G ^@ http://purl.uniprot.org/uniprot/A0A096MXN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD3Z/FCER1G family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:RABEP1 ^@ http://purl.uniprot.org/uniprot/A0A096P2J7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rabaptin family.|||Cytoplasm|||Early endosome|||Endosome http://togogenome.org/gene/9555:RELL1 ^@ http://purl.uniprot.org/uniprot/A0A096NZM7|||http://purl.uniprot.org/uniprot/A0A8I5MV91 ^@ Similarity ^@ Belongs to the RELT family. http://togogenome.org/gene/9555:REEP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MJV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/9555:DES ^@ http://purl.uniprot.org/uniprot/B0CM49 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9555:IFIH1 ^@ http://purl.uniprot.org/uniprot/A0A096NWE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/9555:CX3CR1 ^@ http://purl.uniprot.org/uniprot/A0A096MKX3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1.|||Membrane http://togogenome.org/gene/9555:LOC101022162 ^@ http://purl.uniprot.org/uniprot/A0A096MZA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/9555:CXCL8 ^@ http://purl.uniprot.org/uniprot/C9EI27 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Homodimer.|||Secreted http://togogenome.org/gene/9555:ZNF274 ^@ http://purl.uniprot.org/uniprot/A0A0A0MVX0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:EEF1A1 ^@ http://purl.uniprot.org/uniprot/A9X189 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/9555:LOC101020479 ^@ http://purl.uniprot.org/uniprot/A0A096NCV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9555:SEC61B ^@ http://purl.uniprot.org/uniprot/A0A2I3N4N6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC61-beta family.|||Endoplasmic reticulum membrane|||Membrane|||Necessary for protein translocation in the endoplasmic reticulum. http://togogenome.org/gene/9555:THPO ^@ http://purl.uniprot.org/uniprot/A0A2I3MX71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EPO/TPO family.|||Secreted http://togogenome.org/gene/9555:LOC101016673 ^@ http://purl.uniprot.org/uniprot/A0A096N1A6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c-type heme lyase family.|||Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:LOC100998573 ^@ http://purl.uniprot.org/uniprot/A0A096N8F0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:TOP3B ^@ http://purl.uniprot.org/uniprot/A0A096NSA7 ^@ Function|||Similarity ^@ Belongs to the type IA topoisomerase family.|||Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. http://togogenome.org/gene/9555:ZP3 ^@ http://purl.uniprot.org/uniprot/A0A8I5MUW0 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZP domain family. ZPC subfamily.|||Cell membrane|||Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.|||Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.|||The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.|||Zona pellucida http://togogenome.org/gene/9555:ITIH3 ^@ http://purl.uniprot.org/uniprot/A0A096NDX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/9555:PACA-F ^@ http://purl.uniprot.org/uniprot/A4GE63 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9555:SOHLH2 ^@ http://purl.uniprot.org/uniprot/A0A2I3M588 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:KCNAB1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LJ29|||http://purl.uniprot.org/uniprot/A0A2I3LU74|||http://purl.uniprot.org/uniprot/A0A2I3MTK6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the shaker potassium channel beta subunit family.|||Cell membrane|||Cytoplasm|||Membrane|||Monomer. http://togogenome.org/gene/9555:TMEM106B ^@ http://purl.uniprot.org/uniprot/A0A096NQX8 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/9555:PRPS1L1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NF18 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family.|||Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.|||Homodimer. The active form is probably a hexamer composed of 3 homodimers. http://togogenome.org/gene/9555:C12H11orf88 ^@ http://purl.uniprot.org/uniprot/A0A096N6W8 ^@ Similarity ^@ Belongs to the HOATZ family. http://togogenome.org/gene/9555:ARHGDIB ^@ http://purl.uniprot.org/uniprot/A0A2I3MJB7 ^@ Similarity ^@ Belongs to the Rho GDI family. http://togogenome.org/gene/9555:UBA52 ^@ http://purl.uniprot.org/uniprot/A0A2I3MBB6|||http://purl.uniprot.org/uniprot/A0A8I5R2T0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Component of the 60S subunit of the ribosome.|||Cytoplasm|||In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.|||In the N-terminal section; belongs to the ubiquitin family.|||Nucleus|||Part of the 60S ribosomal subunit. http://togogenome.org/gene/9555:LOC101009930 ^@ http://purl.uniprot.org/uniprot/A0A8I5N7X0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/9555:ADH6 ^@ http://purl.uniprot.org/uniprot/A0A096MWH5 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/9555:GPR15 ^@ http://purl.uniprot.org/uniprot/A0A096NA54 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9555:RRP36 ^@ http://purl.uniprot.org/uniprot/A0A096NI93 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with 90S and pre-40S pre-ribosomal particles.|||Belongs to the RRP36 family.|||Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.|||nucleolus http://togogenome.org/gene/9555:SETD7 ^@ http://purl.uniprot.org/uniprot/A0A096MZ84 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.|||Chromosome|||Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.|||Nucleus http://togogenome.org/gene/9555:TBCA ^@ http://purl.uniprot.org/uniprot/A0A2I3NAV7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TBCA family.|||Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.|||Tubulin-folding protein; involved in the early step of the tubulin folding pathway.|||cytoskeleton http://togogenome.org/gene/9555:CYSLTR2 ^@ http://purl.uniprot.org/uniprot/A0A096MYP2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9555:OR52N4 ^@ http://purl.uniprot.org/uniprot/A9L8V4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:PHF1 ^@ http://purl.uniprot.org/uniprot/A0A096NHI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Polycomblike family.|||Nucleus http://togogenome.org/gene/9555:CSF1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LVH4 ^@ Function|||Subunit ^@ Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.|||Homodimer or heterodimer; disulfide-linked. Interacts with CSF1R. http://togogenome.org/gene/9555:NR6A1 ^@ http://purl.uniprot.org/uniprot/A0A096P0L9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9555:CENPA ^@ http://purl.uniprot.org/uniprot/A0A096NYQ3 ^@ Similarity ^@ Belongs to the histone H3 family. http://togogenome.org/gene/9555:ZFPM2 ^@ http://purl.uniprot.org/uniprot/A0A8I5MUL8|||http://purl.uniprot.org/uniprot/A0A8I5NGX5|||http://purl.uniprot.org/uniprot/A0A8I5R987 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:LOC101021313 ^@ http://purl.uniprot.org/uniprot/A0A2I3MIV9 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/9555:PPP5C ^@ http://purl.uniprot.org/uniprot/A0A0A0MV89 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily. http://togogenome.org/gene/9555:SSU72 ^@ http://purl.uniprot.org/uniprot/A0A2I3MGT6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SSU72 phosphatase family.|||Nucleus|||Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. http://togogenome.org/gene/9555:DPF1 ^@ http://purl.uniprot.org/uniprot/A0A0A0MV96|||http://purl.uniprot.org/uniprot/A0A2I3LPB8 ^@ Similarity ^@ Belongs to the requiem/DPF family. http://togogenome.org/gene/9555:MAPKAPK3 ^@ http://purl.uniprot.org/uniprot/A0A8I5MXH4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:UGT1A1 ^@ http://purl.uniprot.org/uniprot/Q20CL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9555:FOLR1 ^@ http://purl.uniprot.org/uniprot/A0A096MMB1 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/9555:DNAJC25 ^@ http://purl.uniprot.org/uniprot/A0A8I5N8I6 ^@ Similarity ^@ Belongs to the DNAJC25 family. http://togogenome.org/gene/9555:BSCL2 ^@ http://purl.uniprot.org/uniprot/A0A096MPF1 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:TNFRSF11B ^@ http://purl.uniprot.org/uniprot/A0A096N1R7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:JPH2 ^@ http://purl.uniprot.org/uniprot/A0A096NXA9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the junctophilin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.|||Membrane http://togogenome.org/gene/9555:CTBS ^@ http://purl.uniprot.org/uniprot/A0A096N711 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 18 family.|||Lysosome http://togogenome.org/gene/9555:NFU1 ^@ http://purl.uniprot.org/uniprot/A0A096NUG8 ^@ Similarity ^@ Belongs to the NifU family. http://togogenome.org/gene/9555:ZNF711 ^@ http://purl.uniprot.org/uniprot/A0A2I3MH68|||http://purl.uniprot.org/uniprot/A0A2I3MKH3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:SF3B3 ^@ http://purl.uniprot.org/uniprot/A0A096NR05 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:RARRES2 ^@ http://purl.uniprot.org/uniprot/A0A096MWR4 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9555:TM4SF1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LJ02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9555:STC1 ^@ http://purl.uniprot.org/uniprot/A0A8I5N9L1 ^@ Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9555:CHRNA3 ^@ http://purl.uniprot.org/uniprot/A0A8I5NN19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9555:FABP4 ^@ http://purl.uniprot.org/uniprot/A0A8I5NGC9 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9555:MTCH1 ^@ http://purl.uniprot.org/uniprot/A0A096NHU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9555:ALDH6A1 ^@ http://purl.uniprot.org/uniprot/A0A096N5G8|||http://purl.uniprot.org/uniprot/A0A8I5R9H7 ^@ Function|||Similarity ^@ Belongs to the aldehyde dehydrogenase family.|||Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA. http://togogenome.org/gene/9555:LHX4 ^@ http://purl.uniprot.org/uniprot/A0A096MXS7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:NEUROD1 ^@ http://purl.uniprot.org/uniprot/A0A096MR04 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:TBL1XR1 ^@ http://purl.uniprot.org/uniprot/A0A096NXK0 ^@ Similarity ^@ Belongs to the WD repeat EBI family. http://togogenome.org/gene/9555:RPL26 ^@ http://purl.uniprot.org/uniprot/A0A096P2V0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/9555:INKA2 ^@ http://purl.uniprot.org/uniprot/A0A096N1Z6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INKA family.|||Nucleus http://togogenome.org/gene/9555:USP1 ^@ http://purl.uniprot.org/uniprot/A0A096MS83 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9555:SNX13 ^@ http://purl.uniprot.org/uniprot/A0A8I5N909 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9555:MASP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LZ84 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:COQ10B ^@ http://purl.uniprot.org/uniprot/A0A2I3LCE6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the COQ10 family.|||Interacts with coenzyme Q.|||Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. http://togogenome.org/gene/9555:MARCHF11 ^@ http://purl.uniprot.org/uniprot/A0A096MKZ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:EIF4E2 ^@ http://purl.uniprot.org/uniprot/A0A096N2E7|||http://purl.uniprot.org/uniprot/A0A2I3MEE8 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/9555:ELOVL1 ^@ http://purl.uniprot.org/uniprot/A0A096N934 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ELO family. ELOVL1 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.|||Endoplasmic reticulum membrane|||Interacts with LASS2, TECR and HSD17B12.|||Membrane|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9555:GSK3A ^@ http://purl.uniprot.org/uniprot/A0A096N746 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. http://togogenome.org/gene/9555:CRX ^@ http://purl.uniprot.org/uniprot/A0A0A0MV98 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:GPR157 ^@ http://purl.uniprot.org/uniprot/A0A096N790 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:BUD31 ^@ http://purl.uniprot.org/uniprot/A0A096N3M8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BUD31 (G10) family.|||Nucleus http://togogenome.org/gene/9555:TIMP3 ^@ http://purl.uniprot.org/uniprot/A9CB46 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/9555:GNG10 ^@ http://purl.uniprot.org/uniprot/A0A096P0W1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9555:RBP5 ^@ http://purl.uniprot.org/uniprot/A0A096MZT9 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9555:QPCT ^@ http://purl.uniprot.org/uniprot/A0A096NRF7 ^@ Similarity ^@ Belongs to the glutaminyl-peptide cyclotransferase family. http://togogenome.org/gene/9555:SRP19 ^@ http://purl.uniprot.org/uniprot/A0A096NQR6|||http://purl.uniprot.org/uniprot/A0A2I3MCD6|||http://purl.uniprot.org/uniprot/A0A8I5NFQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP19 family.|||Cytoplasm http://togogenome.org/gene/9555:CNTN1 ^@ http://purl.uniprot.org/uniprot/A0A2I3NE30 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. Contactin family. http://togogenome.org/gene/9555:RPS25 ^@ http://purl.uniprot.org/uniprot/A0A096N7S1 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS25 family.|||Component of the small ribosomal subunit. http://togogenome.org/gene/9555:PARVG ^@ http://purl.uniprot.org/uniprot/A0A096NKK9|||http://purl.uniprot.org/uniprot/A0A8I5R9F6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the parvin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:HOXD1 ^@ http://purl.uniprot.org/uniprot/A0A096N796 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Labial subfamily.|||Nucleus http://togogenome.org/gene/9555:HS3ST6 ^@ http://purl.uniprot.org/uniprot/A0A096NKY4 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9555:HMGCS1 ^@ http://purl.uniprot.org/uniprot/A0A8I5R2Z4 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family.|||Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. http://togogenome.org/gene/9555:GALNT18 ^@ http://purl.uniprot.org/uniprot/A0A8I5MWN7|||http://purl.uniprot.org/uniprot/A0A8I5NFF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9555:TGFBI ^@ http://purl.uniprot.org/uniprot/A0A2I3MDA6 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9555:GFOD1 ^@ http://purl.uniprot.org/uniprot/A0A096NL02 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. http://togogenome.org/gene/9555:LOC101024001 ^@ http://purl.uniprot.org/uniprot/A0A096NVN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase D subunit family.|||cilium|||clathrin-coated vesicle membrane http://togogenome.org/gene/9555:ZNF197 ^@ http://purl.uniprot.org/uniprot/A0A096NDF2|||http://purl.uniprot.org/uniprot/A0A2I3LX10 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:FHL5 ^@ http://purl.uniprot.org/uniprot/A0A096NW34 ^@ Function|||Subcellular Location Annotation ^@ May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.|||Nucleus http://togogenome.org/gene/9555:LOC101020174 ^@ http://purl.uniprot.org/uniprot/A0A8I5NRK6 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9555:GABARAPL2 ^@ http://purl.uniprot.org/uniprot/A0A096MVY1 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9555:QRSL1 ^@ http://purl.uniprot.org/uniprot/A0A096NR63 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/9555:GJB6 ^@ http://purl.uniprot.org/uniprot/A0A096NBF9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9555:DERL2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LJ36 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:SIM1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MGA3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:ALOX12B ^@ http://purl.uniprot.org/uniprot/A0A096P2T3 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the lipoxygenase family.|||Binds 1 Fe cation per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:CIAO2A ^@ http://purl.uniprot.org/uniprot/A0A096NMB2 ^@ Similarity ^@ Belongs to the MIP18 family. http://togogenome.org/gene/9555:RNF114 ^@ http://purl.uniprot.org/uniprot/A0A8I5N173 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.|||Nucleus http://togogenome.org/gene/9555:OCRL ^@ http://purl.uniprot.org/uniprot/A0A096MP77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.|||Early endosome membrane|||Endosome membrane|||Membrane|||phagosome membrane http://togogenome.org/gene/9555:MANBAL ^@ http://purl.uniprot.org/uniprot/A0A096NXH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0239 family.|||Membrane http://togogenome.org/gene/9555:SLC2A4 ^@ http://purl.uniprot.org/uniprot/A0A096P2N6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Endomembrane system|||Membrane|||perinuclear region http://togogenome.org/gene/9555:ABHD2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MMH5 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/9555:SPR ^@ http://purl.uniprot.org/uniprot/A0A8I5NN64 ^@ Similarity ^@ Belongs to the sepiapterin reductase family. http://togogenome.org/gene/9555:MED19 ^@ http://purl.uniprot.org/uniprot/A0A096MS19 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 19 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9555:ELK1 ^@ http://purl.uniprot.org/uniprot/A0A096ND19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9555:TPI1 ^@ http://purl.uniprot.org/uniprot/A0A096NGJ9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Homodimer.|||It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.|||Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. http://togogenome.org/gene/9555:TMEM161A ^@ http://purl.uniprot.org/uniprot/A0A2I3LMX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM161 family.|||Membrane http://togogenome.org/gene/9555:VPS25 ^@ http://purl.uniprot.org/uniprot/A0A2I3MUY2 ^@ Similarity ^@ Belongs to the VPS25 family. http://togogenome.org/gene/9555:TMEM205 ^@ http://purl.uniprot.org/uniprot/A0A0A0MVE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM205 family.|||Membrane http://togogenome.org/gene/9555:MPC1 ^@ http://purl.uniprot.org/uniprot/A0A2I3NA47 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:AK5 ^@ http://purl.uniprot.org/uniprot/A0A096N7X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylate kinase family.|||Cytoplasm http://togogenome.org/gene/9555:NGRN ^@ http://purl.uniprot.org/uniprot/A0A096NNA3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the neugrin family.|||Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct.|||Mitochondrion membrane|||Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system. http://togogenome.org/gene/9555:ATG4D ^@ http://purl.uniprot.org/uniprot/A0A0A0MUM9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/9555:GRM3 ^@ http://purl.uniprot.org/uniprot/A0A096NQX7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.|||Interacts with TAMALIN.|||Membrane http://togogenome.org/gene/9555:TMEM63B ^@ http://purl.uniprot.org/uniprot/A0A096NIJ7|||http://purl.uniprot.org/uniprot/A0A2I3MB99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/9555:WFDC5 ^@ http://purl.uniprot.org/uniprot/A4K2M5 ^@ Function|||Subcellular Location Annotation ^@ Putative acid-stable proteinase inhibitor.|||Secreted http://togogenome.org/gene/9555:SCAMP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3NGP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/9555:DHH ^@ http://purl.uniprot.org/uniprot/A0A096NG69 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the hedgehog family.|||Cell membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane|||Multimer.|||The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.|||The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development. http://togogenome.org/gene/9555:SEZ6L2 ^@ http://purl.uniprot.org/uniprot/A0A096NMJ8|||http://purl.uniprot.org/uniprot/A0A2I3LRH1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:PPP1CB ^@ http://purl.uniprot.org/uniprot/A0A2I3MHU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family. PP-1 subfamily.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9555:PGK1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MH89 ^@ Similarity|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Monomer. http://togogenome.org/gene/9555:PSMF1 ^@ http://purl.uniprot.org/uniprot/A0A8I5P2Y5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the proteasome inhibitor PI31 family.|||Cytoplasm|||Endoplasmic reticulum|||Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28. http://togogenome.org/gene/9555:REM2 ^@ http://purl.uniprot.org/uniprot/A0A096NSD3 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9555:MRPL20 ^@ http://purl.uniprot.org/uniprot/A0A096NGL3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family. http://togogenome.org/gene/9555:HK3 ^@ http://purl.uniprot.org/uniprot/A0A096ND12 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/9555:UBE2R2 ^@ http://purl.uniprot.org/uniprot/A0A096P1B9 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9555:RHBG ^@ http://purl.uniprot.org/uniprot/A0A096MU04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/9555:TMEM41A ^@ http://purl.uniprot.org/uniprot/A0A096NQB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM41 family.|||Membrane http://togogenome.org/gene/9555:PSMC3IP ^@ http://purl.uniprot.org/uniprot/A0A096P5T8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HOP2 family.|||Nucleus http://togogenome.org/gene/9555:RNF10 ^@ http://purl.uniprot.org/uniprot/A0A096N564 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNF10 family.|||Cytoplasm http://togogenome.org/gene/9555:SNW1 ^@ http://purl.uniprot.org/uniprot/A0A096NSA5|||http://purl.uniprot.org/uniprot/A0A2I3LM57 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNW family.|||Identified in the spliceosome C complex.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/9555:ACTR2 ^@ http://purl.uniprot.org/uniprot/A0A096P076|||http://purl.uniprot.org/uniprot/A0A2I3LLE2 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9555:MED24 ^@ http://purl.uniprot.org/uniprot/A0A2I3LQV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 24 family.|||Nucleus http://togogenome.org/gene/9555:NPY ^@ http://purl.uniprot.org/uniprot/A0A8I5NK89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Secreted http://togogenome.org/gene/9555:RNASEH1 ^@ http://purl.uniprot.org/uniprot/A0A096NIL0 ^@ Function|||Similarity ^@ Belongs to the RNase H family.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. http://togogenome.org/gene/9555:ZKSCAN2 ^@ http://purl.uniprot.org/uniprot/A0A096NHI0 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9555:LOC108582545 ^@ http://purl.uniprot.org/uniprot/A0A8I5R6D0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/9555:VAMP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3N830 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9555:KIF20A ^@ http://purl.uniprot.org/uniprot/A0A096ND15 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9555:LOC100997976 ^@ http://purl.uniprot.org/uniprot/A0A2I3M5Q6 ^@ Similarity ^@ Belongs to the cornifin (SPRR) family. http://togogenome.org/gene/9555:MLLT11 ^@ http://purl.uniprot.org/uniprot/A0A2I3MZ96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MLLT11 family.|||Nucleus|||centrosome http://togogenome.org/gene/9555:SUPT5H ^@ http://purl.uniprot.org/uniprot/A0A2I3MRZ8|||http://purl.uniprot.org/uniprot/A0A2I3MVF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT5 family.|||Nucleus http://togogenome.org/gene/9555:GMPPA ^@ http://purl.uniprot.org/uniprot/B0CM52 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with GMPPB.|||Belongs to the transferase hexapeptide repeat family.|||Cytoplasm|||GMPPA is a close homolog of GMPPB, that has been shown to catalyze the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids. It has been hypothesized that GMPPA might serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose. Alignment of GMPPAs and GMPPBs from various species shows that GMPPAs are characterized by a 2 amino acid-insertion (residues 11-12) in a highly conserved motif that borders the catalytic pocket and binds the nucleotide substrate in homologous enzymes. This insertion might inactivate the ancestral catalytic site, converting it to an allosteric site.|||May serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose. http://togogenome.org/gene/9555:DYNC1I2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LYG4 ^@ Similarity ^@ Belongs to the dynein intermediate chain family. http://togogenome.org/gene/9555:CDC42SE1 ^@ http://purl.uniprot.org/uniprot/A0A096MWP8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CDC42SE/SPEC family.|||Cell membrane|||Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.|||Membrane|||Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.|||cytoskeleton http://togogenome.org/gene/9555:CCNG2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NA55 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9555:SESN3 ^@ http://purl.uniprot.org/uniprot/A0A096N6P7|||http://purl.uniprot.org/uniprot/A0A8I5R202 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/9555:MMP24 ^@ http://purl.uniprot.org/uniprot/B0CM76 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9555:ACVR2A ^@ http://purl.uniprot.org/uniprot/A0A096NSM4|||http://purl.uniprot.org/uniprot/A0A096NSM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9555:PACSIN2 ^@ http://purl.uniprot.org/uniprot/A0A096NKG3|||http://purl.uniprot.org/uniprot/A0A2I3NEA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PACSIN family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Early endosome|||Endosome membrane|||Membrane|||Recycling endosome membrane|||caveola|||cytoskeleton|||ruffle membrane http://togogenome.org/gene/9555:ME3 ^@ http://purl.uniprot.org/uniprot/A0A096MZZ6 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/9555:SLC22A8 ^@ http://purl.uniprot.org/uniprot/A0A096NDC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.|||Cell membrane http://togogenome.org/gene/9555:RPS19BP1 ^@ http://purl.uniprot.org/uniprot/A0A096NK65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AROS family.|||nucleolus http://togogenome.org/gene/9555:RNF8 ^@ http://purl.uniprot.org/uniprot/A0A096NHV0 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ According to a well-established model, RNF8 initiate H2A 'Lys-63'-linked ubiquitination leading to recruitment of RNF168 to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.|||Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger.|||Belongs to the CHFR family.|||Belongs to the RNF8 family.|||Cytoplasm|||E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains. Promotes non-homologous end joining (NHEJ) by promoting the 'Lys-48'-linked ubiquitination and degradation the of KU80/XRCC5. Following DNA damage, mediates the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF168, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Following DNA damage, mediates the ubiquitination and degradation of POLD4/p12, a subunit of DNA polymerase delta. In the absence of POLD4, DNA polymerase delta complex exhibits higher proofreading activity. In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation. Involved in the activation of ATM by promoting histone H2B ubiquitination, which indirectly triggers histone H4 'Lys-16' acetylation (H4K16ac), establishing a chromatin environment that promotes efficient activation of ATM kinase. Required in the testis, where it plays a role in the replacement of histones during spermatogenesis. At uncapped telomeres, promotes the joining of deprotected chromosome ends by inducing H2A ubiquitination and TP53BP1 recruitment, suggesting that it may enhance cancer development by aggravating telomere-induced genome instability in case of telomeric crisis. Promotes the assembly of RAD51 at DNA DSBs in the absence of BRCA1 and TP53BP1 Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. May be required for proper exit from mitosis after spindle checkpoint activation and may regulate cytokinesis. May play a role in the regulation of RXRA-mediated transcriptional activity. Not involved in RXRA ubiquitination by UBE2E2.|||Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N. Interacts with RXRA. Interacts (via FHA domain) with phosphorylated HERC2 (via C-terminus). Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm.|||Midbody|||Nucleus|||The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and phosphorylated HERC2.|||telomere http://togogenome.org/gene/9555:SLC2A8 ^@ http://purl.uniprot.org/uniprot/A0A096P209 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/9555:BZW1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MTU4|||http://purl.uniprot.org/uniprot/A0A8I5NJ78 ^@ Similarity ^@ Belongs to the BZW family. http://togogenome.org/gene/9555:LBP ^@ http://purl.uniprot.org/uniprot/A0A096NXF9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.|||Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.|||Secreted|||When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14. http://togogenome.org/gene/9555:SNX21 ^@ http://purl.uniprot.org/uniprot/A0A096NX33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome membrane|||Membrane http://togogenome.org/gene/9555:LOC101021342 ^@ http://purl.uniprot.org/uniprot/A0A8I5NZQ0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:CHRM1 ^@ http://purl.uniprot.org/uniprot/A0A096NB06 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. http://togogenome.org/gene/9555:PMVK ^@ http://purl.uniprot.org/uniprot/A0A8I5NET5 ^@ Subcellular Location Annotation ^@ cytosol http://togogenome.org/gene/9555:ATP1B1 ^@ http://purl.uniprot.org/uniprot/A0A096MRZ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9555:LLPH ^@ http://purl.uniprot.org/uniprot/A0A096MY12 ^@ Similarity ^@ Belongs to the learning-associated protein family. http://togogenome.org/gene/9555:SLC9A6 ^@ http://purl.uniprot.org/uniprot/A0A2I3M5V4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/9555:KCNF1 ^@ http://purl.uniprot.org/uniprot/A0A096N9H4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9555:TMSB4X ^@ http://purl.uniprot.org/uniprot/A0A2I3MP40 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/9555:JPH1 ^@ http://purl.uniprot.org/uniprot/A0A096NGB3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the junctophilin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.|||Membrane http://togogenome.org/gene/9555:SEMA3C ^@ http://purl.uniprot.org/uniprot/A0A096MZM1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9555:OLFR575 ^@ http://purl.uniprot.org/uniprot/A9L8W0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:SLC35D2 ^@ http://purl.uniprot.org/uniprot/A0A8I5MXV7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:NPBWR2 ^@ http://purl.uniprot.org/uniprot/A0A8I5R6F3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:PDLIM3 ^@ http://purl.uniprot.org/uniprot/A0A096NBY9|||http://purl.uniprot.org/uniprot/A0A2I3MTF0 ^@ Subcellular Location Annotation ^@ Z line http://togogenome.org/gene/9555:UIMC1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LMK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAP80 family.|||Nucleus http://togogenome.org/gene/9555:MGRN1 ^@ http://purl.uniprot.org/uniprot/A0A096NLF7|||http://purl.uniprot.org/uniprot/A0A2I3LJT9|||http://purl.uniprot.org/uniprot/A0A2I3NA61 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin ligase. http://togogenome.org/gene/9555:KLC2 ^@ http://purl.uniprot.org/uniprot/A0A096N551 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kinesin light chain family.|||Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.|||Oligomeric complex composed of two heavy chains and two light chains.|||cytoskeleton http://togogenome.org/gene/9555:TMED9 ^@ http://purl.uniprot.org/uniprot/A0A8I5N749 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:FNIP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LSX4|||http://purl.uniprot.org/uniprot/A0A2I3MXR8|||http://purl.uniprot.org/uniprot/A0A2I3N7F9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNIP family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9555:RAB9A ^@ http://purl.uniprot.org/uniprot/A0A096MQ80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||phagosome membrane http://togogenome.org/gene/9555:CCL19 ^@ http://purl.uniprot.org/uniprot/A0A2I3MYR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9555:AARS2 ^@ http://purl.uniprot.org/uniprot/A0A096NIM6 ^@ Caution|||Cofactor|||Domain|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||ISGylated.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Interacts with ANKRD16; the interaction is direct. http://togogenome.org/gene/9555:IL12B ^@ http://purl.uniprot.org/uniprot/Q865Y3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity).|||Belongs to the IL-12B family.|||Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.|||Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer. Interacts with NBR1; this interaction promotes IL-12 secretion (By similarity).|||Secreted http://togogenome.org/gene/9555:CCNA2 ^@ http://purl.uniprot.org/uniprot/A0A096NPY9 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin AB subfamily. http://togogenome.org/gene/9555:LOC101012342 ^@ http://purl.uniprot.org/uniprot/A0A8I5NQP4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:LOC108584506 ^@ http://purl.uniprot.org/uniprot/A0A2I3MZ68 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9555:HGD ^@ http://purl.uniprot.org/uniprot/A0A096N3L5 ^@ Similarity ^@ Belongs to the homogentisate dioxygenase family. http://togogenome.org/gene/9555:SOST ^@ http://purl.uniprot.org/uniprot/A0A096P5Y4 ^@ Similarity ^@ Belongs to the sclerostin family. http://togogenome.org/gene/9555:PSIP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LU29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HDGF family.|||Nucleus http://togogenome.org/gene/9555:ITPKA ^@ http://purl.uniprot.org/uniprot/A0A096NTN1 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9555:SLC15A3 ^@ http://purl.uniprot.org/uniprot/A0A8I5N644 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. http://togogenome.org/gene/9555:HOXC12 ^@ http://purl.uniprot.org/uniprot/A0A096NC80 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:WDFY2 ^@ http://purl.uniprot.org/uniprot/A0A2I3M153 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9555:TAF15 ^@ http://purl.uniprot.org/uniprot/A0A096P3Y3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TET family.|||Nucleus http://togogenome.org/gene/9555:DOCK2 ^@ http://purl.uniprot.org/uniprot/A0A096MQP9 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9555:DNTTIP1 ^@ http://purl.uniprot.org/uniprot/A0A096NX42 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:VAX2 ^@ http://purl.uniprot.org/uniprot/A0A096MX55 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:MFSD14A ^@ http://purl.uniprot.org/uniprot/A0A096MKK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/9555:ATG7 ^@ http://purl.uniprot.org/uniprot/A0A8I5MXF3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG7 family.|||Cytoplasm|||E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress.|||Homodimer.|||Preautophagosomal structure http://togogenome.org/gene/9555:HOMER2 ^@ http://purl.uniprot.org/uniprot/A0A096NN09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Homer family.|||Cytoplasm|||Postsynaptic density|||Synapse http://togogenome.org/gene/9555:ZDHHC4 ^@ http://purl.uniprot.org/uniprot/A0A096N158 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9555:RBM42 ^@ http://purl.uniprot.org/uniprot/A0A2I3M3G3 ^@ Similarity ^@ Belongs to the RRM RBM42 family. http://togogenome.org/gene/9555:PRPF38A ^@ http://purl.uniprot.org/uniprot/A0A096MRX0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PRP38 family.|||Component of the spliceosome B complex.|||Involved in pre-mRNA splicing as a component of the spliceosome.|||Nucleus http://togogenome.org/gene/9555:RSPH3 ^@ http://purl.uniprot.org/uniprot/B0CM43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the flagellar radial spoke RSP3 family.|||flagellum axoneme http://togogenome.org/gene/9555:TRIM39 ^@ http://purl.uniprot.org/uniprot/A0A096NLR7 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9555:UBE2D2 ^@ http://purl.uniprot.org/uniprot/A0A096MTS7 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9555:CAPN6 ^@ http://purl.uniprot.org/uniprot/A0A096N760 ^@ Caution|||Similarity ^@ Belongs to the peptidase C2 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:NAB1 ^@ http://purl.uniprot.org/uniprot/A0A096MWM0|||http://purl.uniprot.org/uniprot/A0A096N941 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAB family.|||Homomultimers may associate with EGR1 bound to DNA.|||Nucleus http://togogenome.org/gene/9555:NDUFB4 ^@ http://purl.uniprot.org/uniprot/A0A096NXW1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB4 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:RHPN1 ^@ http://purl.uniprot.org/uniprot/A0A096N421 ^@ Similarity ^@ Belongs to the RHPN family. http://togogenome.org/gene/9555:ELOC ^@ http://purl.uniprot.org/uniprot/A0A2I3NGA9 ^@ Similarity ^@ Belongs to the SKP1 family. http://togogenome.org/gene/9555:EIF4A1 ^@ http://purl.uniprot.org/uniprot/A0A096P2R0 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family. eIF4A subfamily.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9555:KCNH6 ^@ http://purl.uniprot.org/uniprot/A0A096P6D6|||http://purl.uniprot.org/uniprot/A0A2I3MK53 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:LOC101007521 ^@ http://purl.uniprot.org/uniprot/A0A8I5P0Z9 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:ST6GAL1 ^@ http://purl.uniprot.org/uniprot/A0A096N7D3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9555:YWHAZ ^@ http://purl.uniprot.org/uniprot/A0A096NQ71 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9555:SLC35E1 ^@ http://purl.uniprot.org/uniprot/A0A0A0MX00 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:DLK2 ^@ http://purl.uniprot.org/uniprot/A0A096NIF2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:ARL2BP ^@ http://purl.uniprot.org/uniprot/A0A096NIQ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARL2BP family.|||Cytoplasm|||Mitochondrion intermembrane space|||Nucleus|||Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.|||centrosome|||cilium basal body http://togogenome.org/gene/9555:EPHA4 ^@ http://purl.uniprot.org/uniprot/A0A096MZK5 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome|||Membrane http://togogenome.org/gene/9555:ND2 ^@ http://purl.uniprot.org/uniprot/K9MUG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 2 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:NKIRAS2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LMA9 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. http://togogenome.org/gene/9555:HSD3B7 ^@ http://purl.uniprot.org/uniprot/A0A096NHW9 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9555:PTPRN ^@ http://purl.uniprot.org/uniprot/A0A096N891|||http://purl.uniprot.org/uniprot/B0CM60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.|||Membrane|||secretory vesicle membrane http://togogenome.org/gene/9555:RIN2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LH19 ^@ Similarity ^@ Belongs to the RIN (Ras interaction/interference) family. http://togogenome.org/gene/9555:DYNC1LI1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LR59 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.|||Belongs to the dynein light intermediate chain family.|||Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).|||cytoskeleton http://togogenome.org/gene/9555:OR51S1 ^@ http://purl.uniprot.org/uniprot/A9L8V8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:CUL4B ^@ http://purl.uniprot.org/uniprot/A0A2I3MIK7 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9555:NAA40 ^@ http://purl.uniprot.org/uniprot/A0A096N1C2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. NAA40 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:ARPC3 ^@ http://purl.uniprot.org/uniprot/A0A096N2G2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC3 family.|||Component of the Arp2/3 complex.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton http://togogenome.org/gene/9555:CTSL ^@ http://purl.uniprot.org/uniprot/A0A096P274 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9555:GLRA2 ^@ http://purl.uniprot.org/uniprot/A0A096NBC6|||http://purl.uniprot.org/uniprot/A0A2I3N1R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/9555:ME2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MJB3 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/9555:LOC101004259 ^@ http://purl.uniprot.org/uniprot/A0A2I3M0J6 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/9555:COPB1 ^@ http://purl.uniprot.org/uniprot/A0A096NEA3|||http://purl.uniprot.org/uniprot/A0A8I5RA07 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ COPI-coated vesicle membrane|||Cytoplasm|||Endoplasmic reticulum-Golgi intermediate compartment|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/9555:TAS2R38 ^@ http://purl.uniprot.org/uniprot/A0A096MKS9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane|||Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. http://togogenome.org/gene/9555:CPSF6 ^@ http://purl.uniprot.org/uniprot/A0A2I3LQP0|||http://purl.uniprot.org/uniprot/A0A2I3MBH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM CPSF6/7 family.|||Nucleus http://togogenome.org/gene/9555:KCTD7 ^@ http://purl.uniprot.org/uniprot/A0A8I5NUV9 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9555:IPO5 ^@ http://purl.uniprot.org/uniprot/A0A096MPU2 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9555:KHDC1 ^@ http://purl.uniprot.org/uniprot/A9X183 ^@ Similarity ^@ Belongs to the KHDC1 family. http://togogenome.org/gene/9555:PRKAR1A ^@ http://purl.uniprot.org/uniprot/A0A096NU08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:NUDT6 ^@ http://purl.uniprot.org/uniprot/A0A096NYH4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family.|||Cytoplasm|||May contribute to the regulation of cell proliferation.|||Mitochondrion|||Monomer and homodimer.|||Nucleus http://togogenome.org/gene/9555:LOC101015332 ^@ http://purl.uniprot.org/uniprot/A0A096NQ36 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:MAP3K11 ^@ http://purl.uniprot.org/uniprot/A0A096N4Z8 ^@ Activity Regulation|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Homodimer.|||Homodimerization via the leucine zipper domains is required for autophosphorylation. http://togogenome.org/gene/9555:NMB ^@ http://purl.uniprot.org/uniprot/A0A2I3M8G3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bombesin/neuromedin-B/ranatensin family.|||Secreted|||neuron projection http://togogenome.org/gene/9555:TCEA1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LGQ0|||http://purl.uniprot.org/uniprot/A0A2I3MD41 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family.|||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.|||Nucleus http://togogenome.org/gene/9555:THBS3 ^@ http://purl.uniprot.org/uniprot/A0A096N055|||http://purl.uniprot.org/uniprot/A0A2I3LKD5 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:PSME1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LW29 ^@ Similarity ^@ Belongs to the PA28 family. http://togogenome.org/gene/9555:INTS12 ^@ http://purl.uniprot.org/uniprot/A0A096NEV3 ^@ Similarity|||Subunit ^@ Belongs to the Integrator subunit 12 family.|||Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12. http://togogenome.org/gene/9555:KYNU ^@ http://purl.uniprot.org/uniprot/A0A096NSL6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kynureninase family.|||Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:SLC25A27 ^@ http://purl.uniprot.org/uniprot/A0A096NIT1|||http://purl.uniprot.org/uniprot/A0A096NIT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9555:ZDHHC20 ^@ http://purl.uniprot.org/uniprot/A0A096N7D5|||http://purl.uniprot.org/uniprot/A0A2I3LYJ1|||http://purl.uniprot.org/uniprot/A0A2I3MVS5 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9555:PTMS ^@ http://purl.uniprot.org/uniprot/A0A096NXZ2 ^@ Similarity ^@ Belongs to the pro/parathymosin family. http://togogenome.org/gene/9555:SLCO3A1 ^@ http://purl.uniprot.org/uniprot/A0A096NNB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:MMP14 ^@ http://purl.uniprot.org/uniprot/A0A096NSD0 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||Cytoplasm|||Melanosome http://togogenome.org/gene/9555:MAN1A1 ^@ http://purl.uniprot.org/uniprot/A0A096NCE2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9555:LOC103881122 ^@ http://purl.uniprot.org/uniprot/A0A8I5N7X0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/9555:CD44 ^@ http://purl.uniprot.org/uniprot/A0A2I3LCP2|||http://purl.uniprot.org/uniprot/A0A2I3LSR3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||microvillus http://togogenome.org/gene/9555:DIPK1A ^@ http://purl.uniprot.org/uniprot/A0A096MKT4 ^@ Similarity ^@ Belongs to the DIPK family. http://togogenome.org/gene/9555:DCC ^@ http://purl.uniprot.org/uniprot/A0A2I3LPB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. DCC family.|||Membrane http://togogenome.org/gene/9555:ADAM9 ^@ http://purl.uniprot.org/uniprot/A0A096MVR7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:PRPS1 ^@ http://purl.uniprot.org/uniprot/A0A096N9P3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family.|||Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.|||Homodimer. The active form is probably a hexamer composed of 3 homodimers. http://togogenome.org/gene/9555:SIAH3 ^@ http://purl.uniprot.org/uniprot/A0A096NYW7 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/9555:PLSCR1 ^@ http://purl.uniprot.org/uniprot/A0A8I5MV85 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/9555:TPM1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MED4|||http://purl.uniprot.org/uniprot/A0A2I3N825|||http://purl.uniprot.org/uniprot/A0A2I3NGQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9555:GPR183 ^@ http://purl.uniprot.org/uniprot/A0A096MVD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:SMIM15 ^@ http://purl.uniprot.org/uniprot/A0A2I3LXD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM15 family.|||Membrane http://togogenome.org/gene/9555:BTG1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NK34 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9555:ITGB2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MWF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane|||Membrane raft http://togogenome.org/gene/9555:ZC3H12C ^@ http://purl.uniprot.org/uniprot/A0A096N6I0|||http://purl.uniprot.org/uniprot/A0A2I3NAU4 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/9555:TECR ^@ http://purl.uniprot.org/uniprot/A0A0A0MVT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:PPP1R1A ^@ http://purl.uniprot.org/uniprot/A0A096NAT9 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 1 family. http://togogenome.org/gene/9555:MFAP1 ^@ http://purl.uniprot.org/uniprot/A9X1C5 ^@ Function|||Similarity ^@ Belongs to the MFAP1 family.|||Involved in pre-mRNA splicing as a component of the spliceosome. http://togogenome.org/gene/9555:SLCO6A1 ^@ http://purl.uniprot.org/uniprot/A0A096MMS0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:LOC101009144 ^@ http://purl.uniprot.org/uniprot/A0A8I5R280 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9555:CBLB ^@ http://purl.uniprot.org/uniprot/A0A096MSA1 ^@ Domain|||Function ^@ E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.|||The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain. http://togogenome.org/gene/9555:RHAG ^@ http://purl.uniprot.org/uniprot/A0A096NIZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/9555:CMTM6 ^@ http://purl.uniprot.org/uniprot/A0A096NH48 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:PF4V1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NMJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9555:GDPGP1 ^@ http://purl.uniprot.org/uniprot/A0A096N5C3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GDPGP1 family.|||Cytoplasm|||Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells. http://togogenome.org/gene/9555:SLC6A2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LMR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9555:SIRT2 ^@ http://purl.uniprot.org/uniprot/A0A0A0MVF2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the sirtuin family. Class I subfamily.|||Binds 1 zinc ion per subunit.|||NAD-dependent protein deacetylase. http://togogenome.org/gene/9555:PARD6A ^@ http://purl.uniprot.org/uniprot/A0A096N273 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAR6 family.|||Cytoplasm|||tight junction http://togogenome.org/gene/9555:GOT1 ^@ http://purl.uniprot.org/uniprot/A0A096P648 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/9555:PLRG1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LFX3 ^@ Similarity ^@ Belongs to the WD repeat PRL1/PRL2 family. http://togogenome.org/gene/9555:DHFR2 ^@ http://purl.uniprot.org/uniprot/A0A096P300 ^@ Similarity ^@ Belongs to the dihydrofolate reductase family. http://togogenome.org/gene/9555:UQCC ^@ http://purl.uniprot.org/uniprot/B0CM77 ^@ Similarity ^@ Belongs to the CBP3 family. http://togogenome.org/gene/9555:SERPINA11 ^@ http://purl.uniprot.org/uniprot/A0A096NJJ3 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9555:UBE2L6 ^@ http://purl.uniprot.org/uniprot/A0A096MUV8 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9555:PTPRK ^@ http://purl.uniprot.org/uniprot/A0A2I3MAY7|||http://purl.uniprot.org/uniprot/A0A2I3MGP1|||http://purl.uniprot.org/uniprot/A0A2I3MJK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.|||Membrane http://togogenome.org/gene/9555:DNASE2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NXG3 ^@ Similarity ^@ Belongs to the DNase II family. http://togogenome.org/gene/9555:LOC103885307 ^@ http://purl.uniprot.org/uniprot/A0A096MPV4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA3 subunit family.|||Complex I is composed of 45 different subunits.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:FAM228A ^@ http://purl.uniprot.org/uniprot/A0A2I3M1I5 ^@ Similarity ^@ Belongs to the FAM228 family. http://togogenome.org/gene/9555:BCL7C ^@ http://purl.uniprot.org/uniprot/A0A096NHV8 ^@ Similarity ^@ Belongs to the BCL7 family. http://togogenome.org/gene/9555:RNF31 ^@ http://purl.uniprot.org/uniprot/A0A096NX89|||http://purl.uniprot.org/uniprot/A0A2I3N3Q1 ^@ Similarity ^@ Belongs to the RBR family. http://togogenome.org/gene/9555:ADCY8 ^@ http://purl.uniprot.org/uniprot/A0A096N068 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/9555:EIF2S2 ^@ http://purl.uniprot.org/uniprot/A0A8I5N9G8 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/9555:ST7L ^@ http://purl.uniprot.org/uniprot/A0A096NBL6|||http://purl.uniprot.org/uniprot/A0A2I3LR55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ST7 family.|||Membrane http://togogenome.org/gene/9555:SLC5A3 ^@ http://purl.uniprot.org/uniprot/A9CB06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:SLC1A3 ^@ http://purl.uniprot.org/uniprot/A0A2I3LY38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9555:CLCN6 ^@ http://purl.uniprot.org/uniprot/A0A2I3M1Q4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:LOC101006759 ^@ http://purl.uniprot.org/uniprot/A0A096MZU2 ^@ Similarity ^@ Belongs to the AIDA family. http://togogenome.org/gene/9555:NOX1 ^@ http://purl.uniprot.org/uniprot/A0A096MKS0|||http://purl.uniprot.org/uniprot/A0A2I3LP20 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:FAM131B ^@ http://purl.uniprot.org/uniprot/A0A8I5N2W8 ^@ Similarity ^@ Belongs to the FAM131 family. http://togogenome.org/gene/9555:CXCL14 ^@ http://purl.uniprot.org/uniprot/A0A096NXY3 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9555:NLK ^@ http://purl.uniprot.org/uniprot/A0A096P379 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9555:CCR9 ^@ http://purl.uniprot.org/uniprot/A0A096NQ44 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9555:PARD6G ^@ http://purl.uniprot.org/uniprot/A0A096NW70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAR6 family.|||Cytoplasm|||tight junction http://togogenome.org/gene/9555:GPBP1L1 ^@ http://purl.uniprot.org/uniprot/A0A096ND91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vasculin family.|||Nucleus http://togogenome.org/gene/9555:MYO1A ^@ http://purl.uniprot.org/uniprot/A0A096MW03 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9555:AP3S2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MTQ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Membrane|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. http://togogenome.org/gene/9555:SNAPC3 ^@ http://purl.uniprot.org/uniprot/A0A096P1I1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNAPC3/SRD2 family.|||Nucleus|||Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.|||Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. http://togogenome.org/gene/9555:LOC101018964 ^@ http://purl.uniprot.org/uniprot/A0A096MP80 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/9555:STAT4 ^@ http://purl.uniprot.org/uniprot/A0A096N8T7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:ARV1 ^@ http://purl.uniprot.org/uniprot/A0A096MPT7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARV1 family.|||Endoplasmic reticulum membrane|||Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.|||Membrane http://togogenome.org/gene/9555:TRAK2 ^@ http://purl.uniprot.org/uniprot/A0A096MUV0|||http://purl.uniprot.org/uniprot/A0A2I3LXG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the milton family.|||Early endosome|||Mitochondrion http://togogenome.org/gene/9555:PIGS ^@ http://purl.uniprot.org/uniprot/A0A096P397 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGS family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:NHSL2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LGX6|||http://purl.uniprot.org/uniprot/A0A2I3MP37 ^@ Similarity ^@ Belongs to the NHS family. http://togogenome.org/gene/9555:ALAD ^@ http://purl.uniprot.org/uniprot/A0A2I3N496 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ALAD family.|||Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.|||Homooctamer; active form. Homohexamer; low activity form. http://togogenome.org/gene/9555:AHSA1 ^@ http://purl.uniprot.org/uniprot/A0A096NS96 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/9555:STK3 ^@ http://purl.uniprot.org/uniprot/A0A096MTT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Nucleus http://togogenome.org/gene/9555:OR52A5 ^@ http://purl.uniprot.org/uniprot/A9L8X3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:LOC101013544 ^@ http://purl.uniprot.org/uniprot/A0A8I5NJA6 ^@ Function|||Subunit ^@ In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9555:TET1 ^@ http://purl.uniprot.org/uniprot/A0A096P519 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TET family.|||Binds 1 Fe(2+) ion per subunit.|||Chromosome|||Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.|||The zinc ions have a structural role. http://togogenome.org/gene/9555:PFDN6 ^@ http://purl.uniprot.org/uniprot/A0A096NHH3 ^@ Function|||Similarity ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. http://togogenome.org/gene/9555:IST1 ^@ http://purl.uniprot.org/uniprot/A0A2I3M7U7|||http://purl.uniprot.org/uniprot/A0A2I3MBT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IST1 family.|||Cytoplasmic vesicle|||Nucleus envelope http://togogenome.org/gene/9555:OXCT1 ^@ http://purl.uniprot.org/uniprot/A0A096MW68 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 3-oxoacid CoA-transferase family.|||Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.|||Mitochondrion http://togogenome.org/gene/9555:GRB10 ^@ http://purl.uniprot.org/uniprot/A0A096N1U5|||http://purl.uniprot.org/uniprot/A0A2I3M4F5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRB7/10/14 family.|||Cytoplasm http://togogenome.org/gene/9555:PACSIN1 ^@ http://purl.uniprot.org/uniprot/A0A096NHL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PACSIN family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||cytosol|||ruffle membrane|||synaptosome http://togogenome.org/gene/9555:TRIM25 ^@ http://purl.uniprot.org/uniprot/A0A096P4Q9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm http://togogenome.org/gene/9555:SETD3 ^@ http://purl.uniprot.org/uniprot/A9X1D0 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.|||Cytoplasm|||Interacts with MYOD1.|||Nucleus|||Phosphorylated by GSK3B, which is required for recognition by the SCF(FBXW7) complex and subsequent degradation.|||Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73'. Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery. Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin.|||The SET domain specifically recognizes and binds actin, suggesting that it does not accommodate substrates diverging from actin.|||Ubiquitinated by the SCF(FBXW7) complex following phosphorylation by GSK3B, leading to its degradation by the proteasome. http://togogenome.org/gene/9555:PAX4 ^@ http://purl.uniprot.org/uniprot/A9RA81 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:MIXL1 ^@ http://purl.uniprot.org/uniprot/A0A096N7V7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:ZZZ3 ^@ http://purl.uniprot.org/uniprot/A0A096MN54 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:PEX1 ^@ http://purl.uniprot.org/uniprot/A0A096NQC4|||http://purl.uniprot.org/uniprot/A0A2I3NCZ7|||http://purl.uniprot.org/uniprot/A0A8I5N2F0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||cytosol http://togogenome.org/gene/9555:TJAP1 ^@ http://purl.uniprot.org/uniprot/A0A8I5N5G6|||http://purl.uniprot.org/uniprot/A0A8I5NJN8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:SCD5 ^@ http://purl.uniprot.org/uniprot/A0A2I3LW05 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Membrane|||The histidine box domains are involved in binding the catalytic metal ions. http://togogenome.org/gene/9555:TTC39A ^@ http://purl.uniprot.org/uniprot/A0A096MLB4 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/9555:RNF7 ^@ http://purl.uniprot.org/uniprot/A0A096N037 ^@ Similarity ^@ Belongs to the RING-box family. http://togogenome.org/gene/9555:NOC4L ^@ http://purl.uniprot.org/uniprot/A0A096N769 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CBF/MAK21 family.|||Nucleus membrane http://togogenome.org/gene/9555:LOC101015647 ^@ http://purl.uniprot.org/uniprot/A0A096MLJ8 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9555:NME6 ^@ http://purl.uniprot.org/uniprot/A0A096MQT0|||http://purl.uniprot.org/uniprot/A0A2I3NBE7 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9555:ACTN4 ^@ http://purl.uniprot.org/uniprot/A0A0A0MU58|||http://purl.uniprot.org/uniprot/A0A2I3MHP8 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/9555:GOSR2 ^@ http://purl.uniprot.org/uniprot/A0A096P674|||http://purl.uniprot.org/uniprot/A0A2I3MM60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOSR2 family.|||Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.|||Membrane http://togogenome.org/gene/9555:EVA1B ^@ http://purl.uniprot.org/uniprot/A0A096N3D7 ^@ Similarity ^@ Belongs to the EVA1 family. http://togogenome.org/gene/9555:NUDT2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LDW7 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/9555:EIF1AX ^@ http://purl.uniprot.org/uniprot/A0A2I3LWL6 ^@ Function|||Similarity ^@ Belongs to the eIF-1A family.|||Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. http://togogenome.org/gene/9555:BLMH ^@ http://purl.uniprot.org/uniprot/A0A096P3M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Cytoplasm http://togogenome.org/gene/9555:ZDHHC14 ^@ http://purl.uniprot.org/uniprot/A0A096MVE9 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9555:XPC ^@ http://purl.uniprot.org/uniprot/A0A8I5NZ98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPC family.|||Nucleus http://togogenome.org/gene/9555:FAM241A ^@ http://purl.uniprot.org/uniprot/A0A096N8N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM241 family.|||Membrane http://togogenome.org/gene/9555:MVP ^@ http://purl.uniprot.org/uniprot/A0A096NMJ5 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. http://togogenome.org/gene/9555:VANGL1 ^@ http://purl.uniprot.org/uniprot/A0A096N7W7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Vang family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:FGD4 ^@ http://purl.uniprot.org/uniprot/A0A096MUL3|||http://purl.uniprot.org/uniprot/A0A2I3N093 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9555:MRPL11 ^@ http://purl.uniprot.org/uniprot/A0A8I5NPG3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL11 family. http://togogenome.org/gene/9555:SEC23A ^@ http://purl.uniprot.org/uniprot/A0A096NUP0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9555:TMEM256 ^@ http://purl.uniprot.org/uniprot/A0A096P2P6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM256 family.|||Membrane http://togogenome.org/gene/9555:APOBEC3G ^@ http://purl.uniprot.org/uniprot/M1GNL8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||Cytoplasm|||DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA.|||Homodimer.|||Nucleus|||P-body|||The CMP/dCMP deaminase domain 1 mediates RNA binding, RNA-dependent oligomerization and virion incorporation whereas the CMP/dCMP deaminase domain 2 confers deoxycytidine deaminase activity and substrate sequence specificity. http://togogenome.org/gene/9555:FAM32A ^@ http://purl.uniprot.org/uniprot/A0A0A0MX01 ^@ Similarity ^@ Belongs to the FAM32 family. http://togogenome.org/gene/9555:AHSA2P ^@ http://purl.uniprot.org/uniprot/A0A096NG92 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/9555:KDSR ^@ http://purl.uniprot.org/uniprot/A0A8I5NHM3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9555:LOC101016765 ^@ http://purl.uniprot.org/uniprot/A0A096MPD3 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:CZIB ^@ http://purl.uniprot.org/uniprot/A0A096N0W1 ^@ Similarity ^@ Belongs to the UPF0587 family. http://togogenome.org/gene/9555:GNG12 ^@ http://purl.uniprot.org/uniprot/A0A8I5NUG3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9555:SDC2 ^@ http://purl.uniprot.org/uniprot/A0A096NEP5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane http://togogenome.org/gene/9555:GMNN ^@ http://purl.uniprot.org/uniprot/A0A096NLD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the geminin family.|||Nucleus http://togogenome.org/gene/9555:EBF2 ^@ http://purl.uniprot.org/uniprot/A0A096N690 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COE family.|||Nucleus http://togogenome.org/gene/9555:CHD6 ^@ http://purl.uniprot.org/uniprot/A0A096NXC8 ^@ Similarity ^@ Belongs to the SNF2/RAD54 helicase family. http://togogenome.org/gene/9555:SLC5A8 ^@ http://purl.uniprot.org/uniprot/A0A8I5NH22 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:SLC25A5 ^@ http://purl.uniprot.org/uniprot/A0A096MZH6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/9555:GCLM ^@ http://purl.uniprot.org/uniprot/A0A096MPX6 ^@ Similarity|||Subunit ^@ Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.|||Heterodimer of a catalytic heavy chain and a regulatory light chain. http://togogenome.org/gene/9555:EIF4EBP2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NUK3 ^@ Similarity ^@ Belongs to the eIF4E-binding protein family. http://togogenome.org/gene/9555:SNRPA1 ^@ http://purl.uniprot.org/uniprot/A0A096NNG4 ^@ Similarity ^@ Belongs to the U2 small nuclear ribonucleoprotein A family. http://togogenome.org/gene/9555:BTC ^@ http://purl.uniprot.org/uniprot/A0A096MX40 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:SUOX ^@ http://purl.uniprot.org/uniprot/A0A2I3N7D0|||http://purl.uniprot.org/uniprot/A0A8I5NE17 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids.|||Homodimer.|||Mitochondrion intermembrane space http://togogenome.org/gene/9555:NAGLU ^@ http://purl.uniprot.org/uniprot/A0A096P5T3 ^@ Subcellular Location Annotation ^@ Lysosome http://togogenome.org/gene/9555:LOC101016467 ^@ http://purl.uniprot.org/uniprot/A0A096NWG4 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Cell projection|||Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Perikaryon|||Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm. http://togogenome.org/gene/9555:TIMM8A ^@ http://purl.uniprot.org/uniprot/A0A8I5N1Z6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9555:SNRPD3 ^@ http://purl.uniprot.org/uniprot/A0A096NW53 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.|||cytosol http://togogenome.org/gene/9555:MMP7 ^@ http://purl.uniprot.org/uniprot/A0A096N6P6 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9555:LOC101005875 ^@ http://purl.uniprot.org/uniprot/A0A096NL51 ^@ Function|||Similarity|||Subunit ^@ Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.|||Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.|||Homodimer. http://togogenome.org/gene/9555:AXL ^@ http://purl.uniprot.org/uniprot/A0A0A0MVB9|||http://purl.uniprot.org/uniprot/A0A2I3M777 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.|||Membrane http://togogenome.org/gene/9555:NKAIN1 ^@ http://purl.uniprot.org/uniprot/A0A8I5QZY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NKAIN family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:LOC101006695 ^@ http://purl.uniprot.org/uniprot/A0A2I3MHA3 ^@ Similarity ^@ Belongs to the CLCR family. http://togogenome.org/gene/9555:PPP1R1B ^@ http://purl.uniprot.org/uniprot/A0A096P5C0|||http://purl.uniprot.org/uniprot/A0A2I3MZ80 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 1 family. http://togogenome.org/gene/9555:RPL28 ^@ http://purl.uniprot.org/uniprot/A0A2I3LHX4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL28 family. http://togogenome.org/gene/9555:FSD1L ^@ http://purl.uniprot.org/uniprot/A0A096P0Z1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:CHRNA10 ^@ http://purl.uniprot.org/uniprot/A0A096MUW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9555:TXNL4A ^@ http://purl.uniprot.org/uniprot/A0A8I5NAF6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/9555:MKX ^@ http://purl.uniprot.org/uniprot/A0A096P3V6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:ALKBH5 ^@ http://purl.uniprot.org/uniprot/A0A096P330 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alkB family.|||Monomer.|||Nucleus speckle http://togogenome.org/gene/9555:LOC101024203 ^@ http://purl.uniprot.org/uniprot/A0A096NCF4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/9555:WDFY1 ^@ http://purl.uniprot.org/uniprot/A0A096NYF9 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9555:PDSS2 ^@ http://purl.uniprot.org/uniprot/A0A096NR69 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9555:ND3 ^@ http://purl.uniprot.org/uniprot/K9MVI1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 3 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.|||Mitochondrion membrane http://togogenome.org/gene/9555:EMC4 ^@ http://purl.uniprot.org/uniprot/A0A096NT90 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC4 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:TRIP12 ^@ http://purl.uniprot.org/uniprot/A0A2I3N142 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPL family. K-HECT subfamily.|||E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins.|||nucleoplasm http://togogenome.org/gene/9555:PPIL3 ^@ http://purl.uniprot.org/uniprot/A0A096MW52 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9555:LOC101001617 ^@ http://purl.uniprot.org/uniprot/A0A096NHK3 ^@ Subcellular Location Annotation ^@ mitochondrion nucleoid http://togogenome.org/gene/9555:PAPSS1 ^@ http://purl.uniprot.org/uniprot/A0A096N6Y3|||http://purl.uniprot.org/uniprot/A0A2I3MNZ8 ^@ Similarity ^@ In the C-terminal section; belongs to the sulfate adenylyltransferase family.|||In the N-terminal section; belongs to the APS kinase family. http://togogenome.org/gene/9555:NEUROD4 ^@ http://purl.uniprot.org/uniprot/A0A096NAD7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:NCOA7 ^@ http://purl.uniprot.org/uniprot/A0A096NCE5 ^@ Similarity ^@ Belongs to the OXR1 family. http://togogenome.org/gene/9555:CLDN7 ^@ http://purl.uniprot.org/uniprot/A0A096P2N5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9555:SF3B5 ^@ http://purl.uniprot.org/uniprot/A0A2I3LT66 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SF3B5 family.|||Component of the spliceosome B complex.|||Nucleus http://togogenome.org/gene/9555:BRI3 ^@ http://purl.uniprot.org/uniprot/A0A096NY86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BRI3 family.|||Membrane|||perinuclear region http://togogenome.org/gene/9555:UFM1 ^@ http://purl.uniprot.org/uniprot/A0A8I5R588 ^@ Function|||Similarity ^@ Belongs to the UFM1 family.|||Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. http://togogenome.org/gene/9555:IRX6 ^@ http://purl.uniprot.org/uniprot/A0A096NIE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/IRO homeobox family.|||Nucleus http://togogenome.org/gene/9555:SLC25A14 ^@ http://purl.uniprot.org/uniprot/A0A096N4W9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9555:MFF ^@ http://purl.uniprot.org/uniprot/A0A096NFC4|||http://purl.uniprot.org/uniprot/A0A2I3LDI3|||http://purl.uniprot.org/uniprot/A0A2I3NGD7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Tango11 family.|||Membrane|||Mitochondrion outer membrane|||Peroxisome|||Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.|||synaptic vesicle http://togogenome.org/gene/9555:ASB17 ^@ http://purl.uniprot.org/uniprot/A0A096ML03 ^@ Function|||Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family.|||May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/9555:TSEN34 ^@ http://purl.uniprot.org/uniprot/A9L912 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA-intron endonuclease family.|||Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.|||Nucleus http://togogenome.org/gene/9555:PTGER3 ^@ http://purl.uniprot.org/uniprot/A0A096N4S2|||http://purl.uniprot.org/uniprot/A0A2I3MHE8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9555:MRPS17 ^@ http://purl.uniprot.org/uniprot/A0A8I5R0A1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/9555:DLX5 ^@ http://purl.uniprot.org/uniprot/A0A8I5R1M4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus http://togogenome.org/gene/9555:UCHL5 ^@ http://purl.uniprot.org/uniprot/A0A2I3N8I6 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/9555:POLL ^@ http://purl.uniprot.org/uniprot/A0A2I3MZX5|||http://purl.uniprot.org/uniprot/E5FGJ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.|||Nucleus http://togogenome.org/gene/9555:IGF2BP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LGX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM IMP/VICKZ family.|||P-body|||Stress granule http://togogenome.org/gene/9555:SORL1 ^@ http://purl.uniprot.org/uniprot/A0A096N4B3|||http://purl.uniprot.org/uniprot/A0A8I5NV82 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS10-related sortilin family. SORL1 subfamily.|||Cell membrane|||Early endosome membrane|||Endoplasmic reticulum membrane|||Endosome membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Recycling endosome membrane|||Secreted|||multivesicular body membrane|||secretory vesicle membrane|||trans-Golgi network membrane http://togogenome.org/gene/9555:ADD1 ^@ http://purl.uniprot.org/uniprot/A0A096NGL5|||http://purl.uniprot.org/uniprot/A0A096NZ36 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/9555:PAICS ^@ http://purl.uniprot.org/uniprot/A0A096N8T6 ^@ Similarity|||Subunit ^@ Homooctamer.|||In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.|||In the N-terminal section; belongs to the SAICAR synthetase family. http://togogenome.org/gene/9555:ACVR1 ^@ http://purl.uniprot.org/uniprot/A0A096NXW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9555:ASIC1 ^@ http://purl.uniprot.org/uniprot/A0A2I3NAH5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:BMT2 ^@ http://purl.uniprot.org/uniprot/A0A096MXD3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the BMT2 family.|||Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.|||S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/9555:PDCD5 ^@ http://purl.uniprot.org/uniprot/A0A8I5MVR8 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/9555:EXOC7 ^@ http://purl.uniprot.org/uniprot/A0A096NT25|||http://purl.uniprot.org/uniprot/A0A2I3LF50|||http://purl.uniprot.org/uniprot/A0A2I3LK61|||http://purl.uniprot.org/uniprot/A0A2I3MYX5 ^@ Function|||Similarity ^@ Belongs to the EXO70 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/9555:IL4 ^@ http://purl.uniprot.org/uniprot/Q865Y0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-4/IL-13 family.|||Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.|||Secreted http://togogenome.org/gene/9555:ADGRL4 ^@ http://purl.uniprot.org/uniprot/A0A096N293 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:ELK4 ^@ http://purl.uniprot.org/uniprot/A0A096MT07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9555:MRPL50 ^@ http://purl.uniprot.org/uniprot/A0A096P105 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL50 family.|||Mitochondrion http://togogenome.org/gene/9555:CSNK2A1 ^@ http://purl.uniprot.org/uniprot/A0A096NV36 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:TMEM214 ^@ http://purl.uniprot.org/uniprot/A0A096NYP2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TMEM214 family.|||Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.|||Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:SKIL ^@ http://purl.uniprot.org/uniprot/A0A8I5N1X4 ^@ Similarity ^@ Belongs to the SKI family. http://togogenome.org/gene/9555:MAP2K5 ^@ http://purl.uniprot.org/uniprot/A0A096NMG1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:PIAS1 ^@ http://purl.uniprot.org/uniprot/A0A096NMG3 ^@ Similarity ^@ Belongs to the PIAS family. http://togogenome.org/gene/9555:EZR ^@ http://purl.uniprot.org/uniprot/A0A096NRZ8 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/9555:NFS1 ^@ http://purl.uniprot.org/uniprot/B0CM84 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. http://togogenome.org/gene/9555:DMRT1 ^@ http://purl.uniprot.org/uniprot/A0A096P1N9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/9555:PROK1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NIU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AVIT (prokineticin) family.|||Secreted http://togogenome.org/gene/9555:MSN ^@ http://purl.uniprot.org/uniprot/A0A096MSB9 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/9555:TNFAIP8L2 ^@ http://purl.uniprot.org/uniprot/A9X192 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Plays a regulatory role in the Toll-like signaling pathway by determining the strength of LPS-induced signaling and gene expression (By similarity). Inhibits TCR-mediated T-cell activation and negatively regulate T-cell function to prevent hyperresponsiveness (By similarity). Inhibits also autolysosome formation via negatively modulating MTOR activation by interacting with RAC1 and promoting the disassociation of the RAC1-MTOR complex (By similarity). Plays an essential role in NK-cell biology by acting as a checkpoint and displaying an expression pattern correlating with NK-cell maturation process and by negatively regulating NK-cell maturation and antitumor immunity (By similarity). Mechanistically, suppresses IL-15-triggered mTOR activity in NK-cells (By similarity).|||Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.|||Cytoplasm|||Lysosome|||May interact with CASP8; however, such result is unclear since could not reproduce the interaction with CASP8. Interacts with RAC1.|||Nucleus|||Phosphorylated by TAK1/MAP3K7; this phosphorylation triggers association with BTRC and subsequent ubiquitination and degradation.|||The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding (By similarity).|||Ubiquitinated in a BTRC-depdent manner; leading to degradation mediated through the proteasome pathway. http://togogenome.org/gene/9555:CCL2 ^@ http://purl.uniprot.org/uniprot/C9EI28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9555:PEX5L ^@ http://purl.uniprot.org/uniprot/A0A096NQK9|||http://purl.uniprot.org/uniprot/A0A2I3LI74|||http://purl.uniprot.org/uniprot/A0A2I3M194|||http://purl.uniprot.org/uniprot/A0A2I3MD95|||http://purl.uniprot.org/uniprot/A0A2I3MVF1|||http://purl.uniprot.org/uniprot/A0A2I3N1Z1|||http://purl.uniprot.org/uniprot/A0A2I3N3L5 ^@ Similarity ^@ Belongs to the peroxisomal targeting signal receptor family. http://togogenome.org/gene/9555:CKMT2 ^@ http://purl.uniprot.org/uniprot/A0A096MNU5 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/9555:LAMP2 ^@ http://purl.uniprot.org/uniprot/A0A096N6N5|||http://purl.uniprot.org/uniprot/A0A2I3M259|||http://purl.uniprot.org/uniprot/A0A2I3NI87 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9555:UBXN1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LXZ4|||http://purl.uniprot.org/uniprot/A0A8I5NYI1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:STK4 ^@ http://purl.uniprot.org/uniprot/A4K2M3 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Autophosphorylated on serine and threonine residues. Phosphorylation at Thr-387 by PKB/AKT1, leads to inhibition of its: kinase activity, nuclear translocation and autophosphorylation at Thr-183. It also diminishes its cleavage by caspases and its ability to phosphorylate FOXO3 (By similarity).|||Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Cytoplasm|||Homodimer; mediated via the coiled-coil region. Interacts with NORE1, which inhibits autoactivation. Interacts with and stabilizes SAV1. Interacts with RASSF1. Interacts with FOXO3. Interacts with RASSF2 (via SARAH domain). Interacts with AR, PKB/AKT1, TNNI3 and SIRT1. Interacts with DLG5 (via PDZ domain 3). Interacts with MARK3 and SCRIB in the presence of DLG5.|||Inhibited by the C-terminal non-catalytic region. Activated by caspase-cleavage. Full activation also requires homodimerization and autophosphorylation of Thr-183. Activated by RASSF1 which acts by preventing its dephosphorylation (By similarity).|||Nucleus|||Proteolytically cleaved by caspase-3 during apoptosis at Asp-326 and Asp-349 resulting in a 37 kDa or a 39 kDa subunit respectively. The 39 kDa subunit is further cleaved into the 37 kDa form. Proteolytic cleavage results in kinase activation and nuclear translocation of the truncated form (MST1/N). It is less likely that cleavage at Asp-349 is a prerequisite for activation as this site is not conserved in the murine ortholog (By similarity).|||Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. http://togogenome.org/gene/9555:RHBDD3 ^@ http://purl.uniprot.org/uniprot/A0A096MWV9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:GATA6 ^@ http://purl.uniprot.org/uniprot/A0A096MVE0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:PSMB3 ^@ http://purl.uniprot.org/uniprot/A0A096P574 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:SLC10A6 ^@ http://purl.uniprot.org/uniprot/A0A096MQT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/9555:GJB1 ^@ http://purl.uniprot.org/uniprot/A0A096NCL7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins. Interacts with CNST.|||Belongs to the connexin family. Beta-type (group I) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9555:COQ7 ^@ http://purl.uniprot.org/uniprot/A0A096N6T5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ7 family.|||Binds 2 iron ions per subunit.|||Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:PJVK ^@ http://purl.uniprot.org/uniprot/A0A096N3U3 ^@ Similarity ^@ Belongs to the gasdermin family. http://togogenome.org/gene/9555:TENM4 ^@ http://purl.uniprot.org/uniprot/A0A096N0I8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tenascin family. Teneurin subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:TMEM159 ^@ http://purl.uniprot.org/uniprot/A0A2I3MLL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LDAF1 family.|||Endoplasmic reticulum membrane|||Lipid droplet|||Membrane http://togogenome.org/gene/9555:GOLT1B ^@ http://purl.uniprot.org/uniprot/A0A096NBK9|||http://purl.uniprot.org/uniprot/A0A2I3N1K4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||May be involved in fusion of ER-derived transport vesicles with the Golgi complex.|||Membrane http://togogenome.org/gene/9555:DENR ^@ http://purl.uniprot.org/uniprot/A0A2I3MMQ2 ^@ Similarity ^@ Belongs to the DENR family. http://togogenome.org/gene/9555:NDUFC2 ^@ http://purl.uniprot.org/uniprot/A0A096MW31 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFC2 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:ECI1 ^@ http://purl.uniprot.org/uniprot/A0A096NL32 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9555:WNT16 ^@ http://purl.uniprot.org/uniprot/A0A096N804 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9555:GPR171 ^@ http://purl.uniprot.org/uniprot/A0A096MXB4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9555:HSPA4L ^@ http://purl.uniprot.org/uniprot/A0A096NPS1|||http://purl.uniprot.org/uniprot/A0A2I3LGI3 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9555:UBR2 ^@ http://purl.uniprot.org/uniprot/A0A096NI56|||http://purl.uniprot.org/uniprot/A0A2I3MCY4 ^@ Function|||Similarity ^@ Belongs to the UBR1 family.|||Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. http://togogenome.org/gene/9555:CELF1 ^@ http://purl.uniprot.org/uniprot/A0A096NSE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CELF/BRUNOL family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:TPM2 ^@ http://purl.uniprot.org/uniprot/A0A096P175|||http://purl.uniprot.org/uniprot/A0A2I3M895|||http://purl.uniprot.org/uniprot/A0A2I3N8T2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9555:MAPK4 ^@ http://purl.uniprot.org/uniprot/A0A096N2D3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9555:SOAT1 ^@ http://purl.uniprot.org/uniprot/A0A096MXS6|||http://purl.uniprot.org/uniprot/A0A2I3LPJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:RAP2B ^@ http://purl.uniprot.org/uniprot/A0A096N9G0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Palmitoylated.|||Recycling endosome membrane|||Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. http://togogenome.org/gene/9555:MLEC ^@ http://purl.uniprot.org/uniprot/A0A096N2K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the malectin family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:RBBP7 ^@ http://purl.uniprot.org/uniprot/A0A096MKM8|||http://purl.uniprot.org/uniprot/A0A2I3LNX3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:SUCLG1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MKP1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).|||Mitochondrion|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. http://togogenome.org/gene/9555:HSD17B3 ^@ http://purl.uniprot.org/uniprot/A0A096P266 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9555:FAM151B ^@ http://purl.uniprot.org/uniprot/A0A096NED9 ^@ Similarity ^@ Belongs to the FAM151 family. http://togogenome.org/gene/9555:SLCO5A1 ^@ http://purl.uniprot.org/uniprot/A0A096MZX1|||http://purl.uniprot.org/uniprot/A0A2I3LHS9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:DLGAP5 ^@ http://purl.uniprot.org/uniprot/A0A096NV78 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/9555:KCNH2 ^@ http://purl.uniprot.org/uniprot/A0A096N4T2|||http://purl.uniprot.org/uniprot/A0A096NPA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily.|||Membrane http://togogenome.org/gene/9555:MYSM1 ^@ http://purl.uniprot.org/uniprot/A0A096N6J6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M67A family. MYSM1 subfamily.|||Nucleus http://togogenome.org/gene/9555:DTNBP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3NE84 ^@ Similarity ^@ Belongs to the dysbindin family. http://togogenome.org/gene/9555:STX7 ^@ http://purl.uniprot.org/uniprot/A0A8I5NUW0 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9555:GBX2 ^@ http://purl.uniprot.org/uniprot/A0A096N887 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:PLOD2 ^@ http://purl.uniprot.org/uniprot/A0A096N1L3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9555:WARS1 ^@ http://purl.uniprot.org/uniprot/A0A096NJR9 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9555:SNTA1 ^@ http://purl.uniprot.org/uniprot/A0A096NUV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntrophin family.|||Cell junction|||cytoskeleton http://togogenome.org/gene/9555:LOC100997097 ^@ http://purl.uniprot.org/uniprot/A0A096NJ60|||http://purl.uniprot.org/uniprot/A0A2I3NEK1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:LOC101012101 ^@ http://purl.uniprot.org/uniprot/A0A096NQ71 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9555:PPP6C ^@ http://purl.uniprot.org/uniprot/A0A096P222 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/9555:TNFAIP2 ^@ http://purl.uniprot.org/uniprot/A0A096NJX5 ^@ Similarity ^@ Belongs to the SEC6 family. http://togogenome.org/gene/9555:DENND6B ^@ http://purl.uniprot.org/uniprot/A0A2I3M7Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DENND6 family.|||Recycling endosome http://togogenome.org/gene/9555:MMP9 ^@ http://purl.uniprot.org/uniprot/A0A096NX22 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||extracellular matrix http://togogenome.org/gene/9555:APOC2 ^@ http://purl.uniprot.org/uniprot/A0A096P2H4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the apolipoprotein C2 family.|||Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase.|||Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing.|||Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma.|||Secreted http://togogenome.org/gene/9555:PELI3 ^@ http://purl.uniprot.org/uniprot/A0A2I3MFB7 ^@ Function|||Similarity ^@ Belongs to the pellino family.|||E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. http://togogenome.org/gene/9555:MTFP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3M1H3 ^@ Similarity ^@ Belongs to the MTFP1 family. http://togogenome.org/gene/9555:NKX2-1 ^@ http://purl.uniprot.org/uniprot/A0A096NUM8|||http://purl.uniprot.org/uniprot/A0A2I3LKG7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:ADRA1D ^@ http://purl.uniprot.org/uniprot/A0A096NVC9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.|||Membrane|||This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. http://togogenome.org/gene/9555:EIF1AD ^@ http://purl.uniprot.org/uniprot/A0A096N550 ^@ Function|||Similarity|||Subunit ^@ Belongs to the EIF1AD family.|||Interacts with GAPDH and STAT1.|||Plays a role into cellular response to oxidative stress. Decreases cell proliferation. http://togogenome.org/gene/9555:CCDC172 ^@ http://purl.uniprot.org/uniprot/A0A096NTT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC172 family.|||Cytoplasm http://togogenome.org/gene/9555:APC ^@ http://purl.uniprot.org/uniprot/A0A2I3LIJ9|||http://purl.uniprot.org/uniprot/A0A2I3MTS7|||http://purl.uniprot.org/uniprot/A0A2I3MYN3|||http://purl.uniprot.org/uniprot/A0A8I5NR64|||http://purl.uniprot.org/uniprot/A0A8I5R541 ^@ Similarity ^@ Belongs to the adenomatous polyposis coli (APC) family. http://togogenome.org/gene/9555:VPS53 ^@ http://purl.uniprot.org/uniprot/A0A096P284 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS53 family.|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9555:S1PR2 ^@ http://purl.uniprot.org/uniprot/A0A0A0MWW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:EXOSC4 ^@ http://purl.uniprot.org/uniprot/A0A096P3J0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:LOC101009495 ^@ http://purl.uniprot.org/uniprot/A0A2I3MH52 ^@ Similarity ^@ Belongs to the pro/parathymosin family. http://togogenome.org/gene/9555:TAF5L ^@ http://purl.uniprot.org/uniprot/A0A096MTF6 ^@ Similarity ^@ Belongs to the WD repeat TAF5 family. http://togogenome.org/gene/9555:TAGLN3 ^@ http://purl.uniprot.org/uniprot/A0A2I3N481 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/9555:PSMD1 ^@ http://purl.uniprot.org/uniprot/A0A096MU22 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S1 family.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. http://togogenome.org/gene/9555:AP1M1 ^@ http://purl.uniprot.org/uniprot/A0A0A0MXC6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Golgi apparatus|||Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9555:KCND2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MMS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.|||Cell junction|||Cell membrane|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane|||dendrite|||dendritic spine http://togogenome.org/gene/9555:LOXL3 ^@ http://purl.uniprot.org/uniprot/A0A096MVB4 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/9555:MARVELD1 ^@ http://purl.uniprot.org/uniprot/A0A096P621 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:CAPRIN1 ^@ http://purl.uniprot.org/uniprot/A0A096NSE3 ^@ Similarity ^@ Belongs to the caprin family. http://togogenome.org/gene/9555:CHMP2A ^@ http://purl.uniprot.org/uniprot/A0A0A0MUF2 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9555:EGFR ^@ http://purl.uniprot.org/uniprot/A0A096MVJ9|||http://purl.uniprot.org/uniprot/A0A8I5NAT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/9555:LOC108583452 ^@ http://purl.uniprot.org/uniprot/A0A096N461 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/9555:BEST4 ^@ http://purl.uniprot.org/uniprot/A0A096N2C8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms calcium-sensitive chloride channels. Permeable to bicarbonate.|||Membrane http://togogenome.org/gene/9555:FAP ^@ http://purl.uniprot.org/uniprot/A0A2I3LD45|||http://purl.uniprot.org/uniprot/A0A2I3M6E8 ^@ Subcellular Location Annotation ^@ Cell membrane|||invadopodium membrane|||lamellipodium membrane http://togogenome.org/gene/9555:WASHC5 ^@ http://purl.uniprot.org/uniprot/A0A096MZ78 ^@ Similarity ^@ Belongs to the strumpellin family. http://togogenome.org/gene/9555:ACAP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3N8X1 ^@ Activity Regulation|||Domain|||Function|||Subcellular Location Annotation ^@ Endosome membrane|||GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.|||GTPase-activating protein for the ADP ribosylation factor family.|||PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.|||The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions. http://togogenome.org/gene/9555:NDUFA1 ^@ http://purl.uniprot.org/uniprot/A0A2I3M0X2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA1 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:PEX6 ^@ http://purl.uniprot.org/uniprot/A0A8I5NVM3 ^@ Subcellular Location Annotation ^@ cytosol http://togogenome.org/gene/9555:C1GALT1 ^@ http://purl.uniprot.org/uniprot/A0A096N1F1|||http://purl.uniprot.org/uniprot/A0A8I5R2M2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.|||Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.|||Membrane http://togogenome.org/gene/9555:SMIM12 ^@ http://purl.uniprot.org/uniprot/A0A096NS22 ^@ Similarity ^@ Belongs to the SMIM12 family. http://togogenome.org/gene/9555:SLC25A46 ^@ http://purl.uniprot.org/uniprot/A0A096MMM2|||http://purl.uniprot.org/uniprot/A0A8I5N1H1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9555:PNLDC1 ^@ http://purl.uniprot.org/uniprot/A0A096NZS6|||http://purl.uniprot.org/uniprot/A0A8I5N2P2|||http://purl.uniprot.org/uniprot/A0A8I5R180 ^@ Similarity ^@ Belongs to the CAF1 family. http://togogenome.org/gene/9555:POLR3D ^@ http://purl.uniprot.org/uniprot/A0A096NU72 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:CLDN15 ^@ http://purl.uniprot.org/uniprot/A0A096NR54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9555:KCNT2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LN14|||http://purl.uniprot.org/uniprot/A0A2I3MYF3|||http://purl.uniprot.org/uniprot/A0A2I3NFX1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9555:DAD1 ^@ http://purl.uniprot.org/uniprot/A0A096N5H4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DAD/OST2 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/9555:PPIP5K1 ^@ http://purl.uniprot.org/uniprot/A9X1B5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histidine acid phosphatase family. VIP1 subfamily.|||Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).|||cytosol http://togogenome.org/gene/9555:CMBL ^@ http://purl.uniprot.org/uniprot/A0A096MSN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dienelactone hydrolase family.|||cytosol http://togogenome.org/gene/9555:TPPP3 ^@ http://purl.uniprot.org/uniprot/A0A096NE34 ^@ Similarity ^@ Belongs to the TPPP family. http://togogenome.org/gene/9555:LOC110740409 ^@ http://purl.uniprot.org/uniprot/A0A8I5P2E7 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9555:PDE3A ^@ http://purl.uniprot.org/uniprot/A0A096MRC0 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9555:MAP4K2 ^@ http://purl.uniprot.org/uniprot/B0CM66 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. http://togogenome.org/gene/9555:LOC101026125 ^@ http://purl.uniprot.org/uniprot/A0A2I3M5V6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9555:BID ^@ http://purl.uniprot.org/uniprot/A0A096NVY7 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2.|||Induces caspases and apoptosis. Counters the protective effect of BCL2.|||Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9555:MECOM ^@ http://purl.uniprot.org/uniprot/A0A2I3LD64|||http://purl.uniprot.org/uniprot/A0A8I5MYV4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:KIF21A ^@ http://purl.uniprot.org/uniprot/A0A096MYX0|||http://purl.uniprot.org/uniprot/A0A2I3M4M6|||http://purl.uniprot.org/uniprot/A0A2I3M778|||http://purl.uniprot.org/uniprot/A0A2I3MNB7|||http://purl.uniprot.org/uniprot/A0A2I3N9H1|||http://purl.uniprot.org/uniprot/A0A2I3NAW7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9555:LCA5L ^@ http://purl.uniprot.org/uniprot/B0CM36 ^@ Similarity ^@ Belongs to the LCA5 family. http://togogenome.org/gene/9555:NKX2-4 ^@ http://purl.uniprot.org/uniprot/A0A096NVR6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:KRT12 ^@ http://purl.uniprot.org/uniprot/A0A096P5J0 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9555:PCBD2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MVR2 ^@ Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family. http://togogenome.org/gene/9555:FOXF1 ^@ http://purl.uniprot.org/uniprot/A0A096MYS8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:SPIN4 ^@ http://purl.uniprot.org/uniprot/A0A096NCX5 ^@ Similarity ^@ Belongs to the SPIN/STSY family. http://togogenome.org/gene/9555:ACTN3 ^@ http://purl.uniprot.org/uniprot/A0A2I3NCY4 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/9555:DNMT3A ^@ http://purl.uniprot.org/uniprot/A0A096MNF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.|||Nucleus http://togogenome.org/gene/9555:PLCD1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MCP9 ^@ Cofactor ^@ Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain. http://togogenome.org/gene/9555:MGA ^@ http://purl.uniprot.org/uniprot/A0A2I3MUK3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9555:LOC100998797 ^@ http://purl.uniprot.org/uniprot/A0A2I3LPQ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing.|||cytosol http://togogenome.org/gene/9555:EIF4G1 ^@ http://purl.uniprot.org/uniprot/A0A096NQ43|||http://purl.uniprot.org/uniprot/A0A2I3LXF0 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4G family. http://togogenome.org/gene/9555:TRIM45 ^@ http://purl.uniprot.org/uniprot/A0A096MWB7|||http://purl.uniprot.org/uniprot/A0A096NE79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm http://togogenome.org/gene/9555:RPL6 ^@ http://purl.uniprot.org/uniprot/A0A096N393 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL6 family. http://togogenome.org/gene/9555:CDV3 ^@ http://purl.uniprot.org/uniprot/A0A096NDE8|||http://purl.uniprot.org/uniprot/A0A2I3LZI7 ^@ Similarity ^@ Belongs to the CDV3 family. http://togogenome.org/gene/9555:ST3GAL2 ^@ http://purl.uniprot.org/uniprot/A0A096NYP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9555:SMAD9 ^@ http://purl.uniprot.org/uniprot/A0A096N7N2|||http://purl.uniprot.org/uniprot/A0A2I3MH57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:ASB7 ^@ http://purl.uniprot.org/uniprot/A0A096NNE9 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9555:FGD3 ^@ http://purl.uniprot.org/uniprot/A0A096P242 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9555:TBX6 ^@ http://purl.uniprot.org/uniprot/A0A096NHQ7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9555:POLD3 ^@ http://purl.uniprot.org/uniprot/A0A096MQG8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:CCNT1 ^@ http://purl.uniprot.org/uniprot/A0A096N2G7 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9555:PSMC2 ^@ http://purl.uniprot.org/uniprot/A0A096NGR2 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9555:MEAF6 ^@ http://purl.uniprot.org/uniprot/A0A096MU84|||http://purl.uniprot.org/uniprot/A0A2I3MD51 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EAF6 family.|||Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.|||Component of the NuA4 histone acetyltransferase complex. Component of the hbo1 complex. Component of the moz/morf complex.|||kinetochore|||nucleolus http://togogenome.org/gene/9555:TINAGL1 ^@ http://purl.uniprot.org/uniprot/A0A096NP97 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/9555:PPIB ^@ http://purl.uniprot.org/uniprot/A0A8I5R512 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9555:BPIFC ^@ http://purl.uniprot.org/uniprot/A9CB43 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.|||Monomer. Homodimer; disulfide-linked.|||Secreted|||The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.|||The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.|||The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. http://togogenome.org/gene/9555:UBE2S ^@ http://purl.uniprot.org/uniprot/A0A8I5N782 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9555:LOC101022109 ^@ http://purl.uniprot.org/uniprot/A9X1D3 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:MCM7 ^@ http://purl.uniprot.org/uniprot/A0A096NAA1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Nucleus http://togogenome.org/gene/9555:CDK5R1 ^@ http://purl.uniprot.org/uniprot/A0A096NC49 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cyclin-dependent kinase 5 activator family.|||Cell membrane|||Heterodimer of a catalytic subunit and a regulatory subunit.|||Membrane http://togogenome.org/gene/9555:PTGER2 ^@ http://purl.uniprot.org/uniprot/A0A096NV02 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9555:GNB4 ^@ http://purl.uniprot.org/uniprot/A0A096N324 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/9555:MRPL40 ^@ http://purl.uniprot.org/uniprot/A0A096NRC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL40 family.|||Mitochondrion http://togogenome.org/gene/9555:RPL37A ^@ http://purl.uniprot.org/uniprot/A0A2I3MX55 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL43 family. http://togogenome.org/gene/9555:ESRRB ^@ http://purl.uniprot.org/uniprot/A0A2I3LDG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/9555:TPD52 ^@ http://purl.uniprot.org/uniprot/A0A2I3LPX4|||http://purl.uniprot.org/uniprot/A0A2I3M0G7|||http://purl.uniprot.org/uniprot/A0A2I3N3Z1 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/9555:PSMB11 ^@ http://purl.uniprot.org/uniprot/A0A096MKX2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:BCL2 ^@ http://purl.uniprot.org/uniprot/A0A096MPU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion outer membrane|||Nucleus membrane http://togogenome.org/gene/9555:SMYD2 ^@ http://purl.uniprot.org/uniprot/A0A8I5N8Q7 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.|||cytosol http://togogenome.org/gene/9555:F9 ^@ http://purl.uniprot.org/uniprot/A0A096NEF0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9555:SLC12A4 ^@ http://purl.uniprot.org/uniprot/A0A2I3N6U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9555:OLR154 ^@ http://purl.uniprot.org/uniprot/A9L8Z7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:CCN1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MZM7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9555:ZFP36L1 ^@ http://purl.uniprot.org/uniprot/A0A096NVR1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.|||Cytoplasm|||Nucleus|||Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. http://togogenome.org/gene/9555:ZC3H12D ^@ http://purl.uniprot.org/uniprot/A0A2I3LFI3 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/9555:PPP1R16A ^@ http://purl.uniprot.org/uniprot/A0A096N2Z2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9555:SEPTIN8 ^@ http://purl.uniprot.org/uniprot/A9CB15 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/9555:RARS1 ^@ http://purl.uniprot.org/uniprot/A0A096MLR0 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9555:SFRP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MJH5 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:TOMM7 ^@ http://purl.uniprot.org/uniprot/A0A8I5NFC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom7 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9555:C2H3orf70 ^@ http://purl.uniprot.org/uniprot/A0A096NC90 ^@ Similarity ^@ Belongs to the UPF0524 family. http://togogenome.org/gene/9555:CMAS ^@ http://purl.uniprot.org/uniprot/A0A096MYY9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CMP-NeuNAc synthase family.|||Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).|||Homotetramer; the active enzyme is formed by a dimer of dimers. http://togogenome.org/gene/9555:GPSM2 ^@ http://purl.uniprot.org/uniprot/A0A096MPG4|||http://purl.uniprot.org/uniprot/A0A8I5MYB5 ^@ Similarity ^@ Belongs to the GPSM family. http://togogenome.org/gene/9555:FIS1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LVY5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FIS1 family.|||Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.|||Membrane|||Mitochondrion outer membrane|||The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission. http://togogenome.org/gene/9555:TRAM2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LFA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAM family.|||Membrane http://togogenome.org/gene/9555:INSL3 ^@ http://purl.uniprot.org/uniprot/A0A0A0MWS1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the insulin family.|||Heterodimer of a B chain and an A chain linked by two disulfide bonds.|||Secreted|||Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor. http://togogenome.org/gene/9555:RAD23A ^@ http://purl.uniprot.org/uniprot/A0A0A0MWE9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAD23 family.|||Cytoplasm|||Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.|||Nucleus http://togogenome.org/gene/9555:CENPS ^@ http://purl.uniprot.org/uniprot/A0A096N6R5 ^@ Similarity ^@ Belongs to the TAF9 family. CENP-S/MHF1 subfamily. http://togogenome.org/gene/9555:RUNDC3B ^@ http://purl.uniprot.org/uniprot/A0A2I3LDJ3|||http://purl.uniprot.org/uniprot/A0A2I3MGN9 ^@ Similarity|||Subunit ^@ Belongs to the RUNDC3 family.|||Interacts with RAP2A. http://togogenome.org/gene/9555:PRKG2 ^@ http://purl.uniprot.org/uniprot/A0A096NC74 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily. http://togogenome.org/gene/9555:HACD3 ^@ http://purl.uniprot.org/uniprot/A0A096NME0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:SHFL ^@ http://purl.uniprot.org/uniprot/A0A2I3MDL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SHFL family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:OR51B6 ^@ http://purl.uniprot.org/uniprot/A9L8Y3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:C10H2orf76 ^@ http://purl.uniprot.org/uniprot/A0A8I5R4Y7 ^@ Similarity ^@ Belongs to the UPF0538 family. http://togogenome.org/gene/9555:APRT ^@ http://purl.uniprot.org/uniprot/A0A096MNR2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.|||Cytoplasm http://togogenome.org/gene/9555:MON1B ^@ http://purl.uniprot.org/uniprot/A0A2I3N5F2 ^@ Function|||Similarity ^@ Belongs to the MON1/SAND family.|||Plays an important role in membrane trafficking through the secretory apparatus. http://togogenome.org/gene/9555:SOAT2 ^@ http://purl.uniprot.org/uniprot/A0A096N7Y7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:SLITRK2 ^@ http://purl.uniprot.org/uniprot/A0A096MTS4 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9555:SLC25A33 ^@ http://purl.uniprot.org/uniprot/A0A096N789 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9555:SMAD4 ^@ http://purl.uniprot.org/uniprot/A0A096N2U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:GPC4 ^@ http://purl.uniprot.org/uniprot/A0A096MRP2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/9555:FABP3 ^@ http://purl.uniprot.org/uniprot/A0A096N101 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9555:NFKB1 ^@ http://purl.uniprot.org/uniprot/A0A096NDA9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9555:STAT6 ^@ http://purl.uniprot.org/uniprot/A0A096MUF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:SCGN ^@ http://purl.uniprot.org/uniprot/A0A096NLE5 ^@ Subcellular Location Annotation ^@ secretory vesicle membrane http://togogenome.org/gene/9555:TRIM11 ^@ http://purl.uniprot.org/uniprot/A0A096N7V8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9555:CLDN1 ^@ http://purl.uniprot.org/uniprot/A0A096N4M8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9555:AKIRIN2 ^@ http://purl.uniprot.org/uniprot/A0A096P086 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus http://togogenome.org/gene/9555:CNDP2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XMP2 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20A family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9555:SAP30 ^@ http://purl.uniprot.org/uniprot/A0A8I5MXQ0 ^@ Similarity ^@ Belongs to the SAP30 family. http://togogenome.org/gene/9555:MBD4 ^@ http://purl.uniprot.org/uniprot/A0A8I5NCH6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with MLH1.|||Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.|||Nucleus http://togogenome.org/gene/9555:CGN ^@ http://purl.uniprot.org/uniprot/A9X1A5 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cingulin family.|||Deletion of the TJP1/ZO1 interaction motif (ZIM) decreases but does not abolish colocalization with TJP1/ZO1.|||Homodimer (By similarity). Interacts with TJP1/ZO1 and SPEF1 (By similarity).|||It is uncertain whether Met-1 or Met-7 is the initiator.|||Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.|||tight junction http://togogenome.org/gene/9555:DOCK1 ^@ http://purl.uniprot.org/uniprot/A0A096NSS0 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9555:ZSCAN21 ^@ http://purl.uniprot.org/uniprot/A0A096MNR4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:TSPAN7 ^@ http://purl.uniprot.org/uniprot/A0A2I3LG35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9555:FARSB ^@ http://purl.uniprot.org/uniprot/A0A8I5NEM7 ^@ Similarity ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily. http://togogenome.org/gene/9555:ENO1 ^@ http://purl.uniprot.org/uniprot/A0A096MWA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/9555:IMPDH2 ^@ http://purl.uniprot.org/uniprot/A0A096NQP5 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.|||Nucleus http://togogenome.org/gene/9555:RBP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LFI2 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9555:SLC7A10 ^@ http://purl.uniprot.org/uniprot/A0A0A0MUG8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:TRMT5 ^@ http://purl.uniprot.org/uniprot/A0A096NVH4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRM5 / TYW2 family.|||Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.|||Cytoplasm|||Mitochondrion matrix|||Monomer.|||Nucleus|||Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. http://togogenome.org/gene/9555:ERCC5 ^@ http://purl.uniprot.org/uniprot/A0A096MYX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.|||Nucleus http://togogenome.org/gene/9555:CEBPZ ^@ http://purl.uniprot.org/uniprot/A0A096NDN3 ^@ Similarity ^@ Belongs to the CBF/MAK21 family. http://togogenome.org/gene/9555:NUBP2 ^@ http://purl.uniprot.org/uniprot/A0A096NKX6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.|||Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.|||Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.|||Cytoplasm|||Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.|||Nucleus|||centrosome http://togogenome.org/gene/9555:MRPL17 ^@ http://purl.uniprot.org/uniprot/A0A096NDY4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL17 family. http://togogenome.org/gene/9555:UNC5D ^@ http://purl.uniprot.org/uniprot/A0A2I3MIP8|||http://purl.uniprot.org/uniprot/A0A2I3ML14|||http://purl.uniprot.org/uniprot/A0A2I3MMZ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-5 family.|||Cell membrane|||Membrane|||Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. http://togogenome.org/gene/9555:CTF1 ^@ http://purl.uniprot.org/uniprot/A0A096NHV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-6 superfamily.|||Secreted http://togogenome.org/gene/9555:PRKRA ^@ http://purl.uniprot.org/uniprot/A0A096NQ26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRKRA family.|||perinuclear region http://togogenome.org/gene/9555:RIMKLA ^@ http://purl.uniprot.org/uniprot/A0A096N1T0 ^@ Similarity ^@ Belongs to the RimK family. http://togogenome.org/gene/9555:NDUFA3 ^@ http://purl.uniprot.org/uniprot/A0A0A0MUY1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA3 subunit family.|||Complex I is composed of 45 different subunits.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:SEC24C ^@ http://purl.uniprot.org/uniprot/A0A096P4M7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9555:FAM221B ^@ http://purl.uniprot.org/uniprot/A0A096P166 ^@ Similarity ^@ Belongs to the FAM221 family. http://togogenome.org/gene/9555:DOK4 ^@ http://purl.uniprot.org/uniprot/A0A096NIT3 ^@ Similarity ^@ Belongs to the DOK family. Type B subfamily. http://togogenome.org/gene/9555:MAPK8 ^@ http://purl.uniprot.org/uniprot/A0A2I3MLZ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/9555:ARL6 ^@ http://purl.uniprot.org/uniprot/A0A096MTK8|||http://purl.uniprot.org/uniprot/A0A2I3LZJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||cilium membrane http://togogenome.org/gene/9555:IL2 ^@ http://purl.uniprot.org/uniprot/Q865Y1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-2 family.|||Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.|||Secreted http://togogenome.org/gene/9555:POU4F2 ^@ http://purl.uniprot.org/uniprot/A0A8I5N472 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/9555:PTDSS2 ^@ http://purl.uniprot.org/uniprot/A0A096N1N4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphatidyl serine synthase family.|||Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:GINS3 ^@ http://purl.uniprot.org/uniprot/A0A096NJ08 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS3/PSF3 family.|||Chromosome|||Component of the GINS complex.|||Nucleus|||The GINS complex plays an essential role in the initiation of DNA replication. http://togogenome.org/gene/9555:NRN1 ^@ http://purl.uniprot.org/uniprot/A0A8I5N5V3 ^@ Similarity ^@ Belongs to the neuritin family. http://togogenome.org/gene/9555:VPS18 ^@ http://purl.uniprot.org/uniprot/A0A096NTJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS18 family.|||Membrane http://togogenome.org/gene/9555:TYMS ^@ http://purl.uniprot.org/uniprot/A0A096N9Z2|||http://purl.uniprot.org/uniprot/A0A8I5R604 ^@ Similarity ^@ Belongs to the thymidylate synthase family. http://togogenome.org/gene/9555:LGMN ^@ http://purl.uniprot.org/uniprot/A0A096NJF1 ^@ Similarity ^@ Belongs to the peptidase C13 family. http://togogenome.org/gene/9555:COX2 ^@ http://purl.uniprot.org/uniprot/C3UVK6|||http://purl.uniprot.org/uniprot/P68297 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Binds a copper A center.|||Binds a dinuclear copper A center per subunit.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2. Interacts with TMEM177 in a COX20-dependent manner. Interacts with COX20. Interacts with COX16 (By similarity).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:SFRP2 ^@ http://purl.uniprot.org/uniprot/A0A096MRM0 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:KCNJ4 ^@ http://purl.uniprot.org/uniprot/A0A096NK17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9555:SCN7A ^@ http://purl.uniprot.org/uniprot/A0A2I3LH88 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel (TC 1.A.1.10) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.|||Membrane http://togogenome.org/gene/9555:ARF5 ^@ http://purl.uniprot.org/uniprot/A9RA79 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/9555:RPL12 ^@ http://purl.uniprot.org/uniprot/A0A096N7R0 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL11 family.|||Binds directly to 26S ribosomal RNA. http://togogenome.org/gene/9555:IMPA1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NT52 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/9555:AHDC1 ^@ http://purl.uniprot.org/uniprot/A0A096N521 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:QPCTL ^@ http://purl.uniprot.org/uniprot/A0A0A0MXI0 ^@ Similarity ^@ Belongs to the glutaminyl-peptide cyclotransferase family. http://togogenome.org/gene/9555:NOVA1 ^@ http://purl.uniprot.org/uniprot/A0A096NXD9|||http://purl.uniprot.org/uniprot/A0A2I3NG33 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with PTBP2; the interaction is direct.|||Nucleus http://togogenome.org/gene/9555:CDC20 ^@ http://purl.uniprot.org/uniprot/A0A096MX65 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/9555:NOL10 ^@ http://purl.uniprot.org/uniprot/A0A2I3LUN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat NOL10/ENP2 family.|||nucleolus http://togogenome.org/gene/9555:CBX1 ^@ http://purl.uniprot.org/uniprot/A0A096P417 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:SCNM1 ^@ http://purl.uniprot.org/uniprot/A9X194 ^@ Subcellular Location Annotation ^@ Nucleus speckle|||nucleoplasm http://togogenome.org/gene/9555:ZNF503 ^@ http://purl.uniprot.org/uniprot/A0A096P4I8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Elbow/Noc family.|||Nucleus http://togogenome.org/gene/9555:DDX58 ^@ http://purl.uniprot.org/uniprot/A0A096P1D9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/9555:ECRG4 ^@ http://purl.uniprot.org/uniprot/A0A096NCD8 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the augurin family.|||Cytoplasm|||Membrane|||Secreted http://togogenome.org/gene/9555:PRKCA ^@ http://purl.uniprot.org/uniprot/A0A096NTX9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.|||Cell membrane|||Cytoplasm|||Membrane|||Mitochondrion membrane|||Nucleus http://togogenome.org/gene/9555:LOC101011394 ^@ http://purl.uniprot.org/uniprot/A0A8I5R776 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:CCM2 ^@ http://purl.uniprot.org/uniprot/A0A096MYG4|||http://purl.uniprot.org/uniprot/A0A2I3LHM5|||http://purl.uniprot.org/uniprot/A0A2I3LQ60 ^@ Similarity ^@ Belongs to the CCM2 family. http://togogenome.org/gene/9555:DEFB118 ^@ http://purl.uniprot.org/uniprot/A0A096NV16 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9555:ACAT2 ^@ http://purl.uniprot.org/uniprot/A0A096N1E5 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/9555:KPNA1 ^@ http://purl.uniprot.org/uniprot/A0A096MMP3 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9555:CRTC2 ^@ http://purl.uniprot.org/uniprot/A0A096MQI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TORC family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:PIK3R2 ^@ http://purl.uniprot.org/uniprot/A0A0A0MVM4 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/9555:HSF1 ^@ http://purl.uniprot.org/uniprot/A0A096ND96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/9555:LOC100998050 ^@ http://purl.uniprot.org/uniprot/A0A096N5U0 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DIPP subfamily. http://togogenome.org/gene/9555:TCN2 ^@ http://purl.uniprot.org/uniprot/A0A096NJJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic cobalamin transport proteins family.|||Secreted http://togogenome.org/gene/9555:PRKCG ^@ http://purl.uniprot.org/uniprot/A0A0A0MVI8|||http://purl.uniprot.org/uniprot/A9L903 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.|||Cytoplasm|||Membrane http://togogenome.org/gene/9555:CHMP3 ^@ http://purl.uniprot.org/uniprot/A0A096NPG9 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9555:HAGH ^@ http://purl.uniprot.org/uniprot/A0A096NKY1 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. http://togogenome.org/gene/9555:LEAP2 ^@ http://purl.uniprot.org/uniprot/A9CB19 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LEAP2 family.|||Has an antimicrobial activity.|||Secreted http://togogenome.org/gene/9555:GNB1 ^@ http://purl.uniprot.org/uniprot/A0A096N6G8 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/9555:CRISP3 ^@ http://purl.uniprot.org/uniprot/A0A096NJ02 ^@ Caution|||Similarity ^@ Belongs to the CRISP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:PORCN ^@ http://purl.uniprot.org/uniprot/A0A096NB64|||http://purl.uniprot.org/uniprot/A0A2I3MA97 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:SERPINB5 ^@ http://purl.uniprot.org/uniprot/A0A096N0K8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the serpin family. Ov-serpin subfamily.|||extracellular space http://togogenome.org/gene/9555:SLC9A9 ^@ http://purl.uniprot.org/uniprot/A0A096MXB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/9555:JAKMIP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LS90|||http://purl.uniprot.org/uniprot/A0A2I3N4I5|||http://purl.uniprot.org/uniprot/A0A2I3NIN0|||http://purl.uniprot.org/uniprot/A0A8I5N6A2 ^@ Similarity ^@ Belongs to the JAKMIP family. http://togogenome.org/gene/9555:MTNR1B ^@ http://purl.uniprot.org/uniprot/A0A096NB84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:PCID2 ^@ http://purl.uniprot.org/uniprot/A9X174 ^@ Similarity ^@ Belongs to the CSN12 family. http://togogenome.org/gene/9555:PGR ^@ http://purl.uniprot.org/uniprot/A7X8C7 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family.|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.|||Cytoplasm|||Interacts with SMARD1 and UNC45A. Interacts with CUEDC2; the interaction promotes ubiquitination, decreases sumoylation, and represses transcriptional activity. Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export. Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-345 by ERK1/2-MAPK. Interacts with PRMT2. Interacts with NCOA2 and NCOA1. Interacts with KLF9. Interacts with GTF2B (By similarity).|||Nucleus|||Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation (By similarity).|||Phosphorylated on multiple serine sites. Several of these sites are hormone-dependent. Phosphorylation on Ser-294 is highly hormone-dependent and modulates ubiquitination and sumoylation on Lys-388. Phosphorylation on Ser-345 also requires induction by hormone. Basal phosphorylation on Ser-81, Ser-162, Ser-190 and Ser-400 is increased in response to progesterone and can be phosphorylated in vitro by the CDK2-A1 complex. Increased levels of phosphorylation on Ser-400 also in the presence of EGF, heregulin, IGF, PMA and FBS. Phosphorylation at this site by CDK2 is ligand-independent, and increases nuclear translocation and transcriptional activity. Phosphorylation at Ser-162 and Ser-294, but not at Ser-190, is impaired during the G(2)/M phase of the cell cycle. Phosphorylation on Ser-345 by ERK1/2 MAPK is required for interaction with SP1 (By similarity).|||Sumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three sites is enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-388, the main site of sumoylation, is repressed by ubiquitination on the same site, and modulated by phosphorylation at Ser-294 (By similarity).|||The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.|||Ubiquitination is hormone-dependent and represses sumoylation on the same site. Promoted by MAPK-mediated phosphorylation on Ser-294 (By similarity). http://togogenome.org/gene/9555:USP14 ^@ http://purl.uniprot.org/uniprot/A0A8I5NBP1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the peptidase C19 family. USP14/UBP6 subfamily.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Interacts with TRIM14; this interaction recruits USP14 to cleave ubiquitin chains of CGAS. http://togogenome.org/gene/9555:ORAI2 ^@ http://purl.uniprot.org/uniprot/A0A8I5R7V9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Orai family.|||Membrane http://togogenome.org/gene/9555:GLI1 ^@ http://purl.uniprot.org/uniprot/A0A096MT80 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/9555:FXYD1 ^@ http://purl.uniprot.org/uniprot/A0A0A0MUU3 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the FXYD family.|||Cell membrane|||Membrane|||T-tubule|||caveola|||sarcolemma http://togogenome.org/gene/9555:SPOPL ^@ http://purl.uniprot.org/uniprot/A0A096N9F4 ^@ Similarity ^@ Belongs to the Tdpoz family. http://togogenome.org/gene/9555:ETNPPL ^@ http://purl.uniprot.org/uniprot/A0A8I5NR10 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9555:TMEM138 ^@ http://purl.uniprot.org/uniprot/A0A096MVD7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM138 family.|||Membrane|||Required for ciliogenesis.|||Vacuole membrane|||cilium http://togogenome.org/gene/9555:BHMT2 ^@ http://purl.uniprot.org/uniprot/A0A096MPL8 ^@ Cofactor|||Function|||Subunit ^@ Binds 1 zinc ion per subunit.|||Homotetramer.|||Involved in the regulation of homocysteine metabolism. http://togogenome.org/gene/9555:TMEM41B ^@ http://purl.uniprot.org/uniprot/A0A096NXQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM41 family.|||Membrane http://togogenome.org/gene/9555:BTF3L4 ^@ http://purl.uniprot.org/uniprot/A0A096N0W2 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/9555:NLGN2 ^@ http://purl.uniprot.org/uniprot/A0A2I3M7Z8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:FAM160B1 ^@ http://purl.uniprot.org/uniprot/A0A096NTS6 ^@ Similarity ^@ Belongs to the FHIP family. http://togogenome.org/gene/9555:PACC1 ^@ http://purl.uniprot.org/uniprot/A0A2I3N0E6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the proton-activated chloride channel family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:FXR2 ^@ http://purl.uniprot.org/uniprot/A0A096P2R4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMR1 family.|||Cytoplasmic ribonucleoprotein granule|||Postsynapse|||Synapse http://togogenome.org/gene/9555:TBCB ^@ http://purl.uniprot.org/uniprot/A0A2I3M6K5 ^@ Similarity ^@ Belongs to the TBCB family. http://togogenome.org/gene/9555:TOM1 ^@ http://purl.uniprot.org/uniprot/A0A096NJR5|||http://purl.uniprot.org/uniprot/A0A8I5NPD7 ^@ Similarity ^@ Belongs to the TOM1 family. http://togogenome.org/gene/9555:PPP2CA ^@ http://purl.uniprot.org/uniprot/A0A8I5N5B9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/9555:RPL14 ^@ http://purl.uniprot.org/uniprot/A0A2I3N5Z6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL14 family. http://togogenome.org/gene/9555:CENPV ^@ http://purl.uniprot.org/uniprot/A0A096P304 ^@ Similarity ^@ Belongs to the Gfa family. http://togogenome.org/gene/9555:LOC101018613 ^@ http://purl.uniprot.org/uniprot/A0A8I5MYE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9555:RNF170 ^@ http://purl.uniprot.org/uniprot/A0A096MT64 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:TIGD4 ^@ http://purl.uniprot.org/uniprot/A0A096MMG9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:ARL11 ^@ http://purl.uniprot.org/uniprot/A0A096N276 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9555:TMED10 ^@ http://purl.uniprot.org/uniprot/A0A096NS51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:CRP ^@ http://purl.uniprot.org/uniprot/A0A096NZ65 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pentraxin family.|||Binds 2 calcium ions per subunit.|||Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9555:PIANP ^@ http://purl.uniprot.org/uniprot/A0A096MN51 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:METTL14 ^@ http://purl.uniprot.org/uniprot/A0A096MUU6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MT-A70-like family.|||Heterodimer; heterodimerizes with METTL3 to form an antiparallel heterodimer that constitutes an active methyltransferase.|||Nucleus|||The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation. In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization. M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis. M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells. http://togogenome.org/gene/9555:HSD17B13 ^@ http://purl.uniprot.org/uniprot/A0A8I5N2A6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9555:C6H6orf89 ^@ http://purl.uniprot.org/uniprot/A0A096NHT3 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9555:SPOCK1 ^@ http://purl.uniprot.org/uniprot/A0A096NEA0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:NF2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MFF5|||http://purl.uniprot.org/uniprot/P59750 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Cell projection|||Interacts with NHERF1, HGS and AGAP2. Interacts with SGSM3. Interacts (via FERM domain) with MPP1 (By similarity). Interacts with LAYN and WWC1. Interacts with the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. The unphosphorylated form interacts (via FERM domain) with VPRBP/DCAF1. Interacts (via FERM domain) with NOP53; the interaction is direct. Interacts with SCHIP1; the interaction is direct.|||Membrane|||Nucleus|||Phosphorylation of Ser-518 inhibits nuclear localization by disrupting the intramolecular association of the FERM domain with the C-terminal tail.|||Phosphorylation of Ser-518 inhibits nuclear localization by disrupting the intramolecular association of the FERM domain with the C-terminal tail. The dephosphorylation of Ser-518 favors the interaction with NOP53.|||Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex (By similarity).|||Ubiquitinated by the CUL4A-RBX1-DDB1-DCAF1/VprBP E3 ubiquitin-protein ligase complex for ubiquitination and subsequent proteasome-dependent degradation.|||cytoskeleton http://togogenome.org/gene/9555:DIS3L ^@ http://purl.uniprot.org/uniprot/A0A096NME7 ^@ Similarity ^@ Belongs to the RNR ribonuclease family. http://togogenome.org/gene/9555:VDAC2 ^@ http://purl.uniprot.org/uniprot/A0A8I5R272 ^@ Similarity ^@ Belongs to the eukaryotic mitochondrial porin family. http://togogenome.org/gene/9555:ZNF75D ^@ http://purl.uniprot.org/uniprot/A0A2I3NBM2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:ALAS1 ^@ http://purl.uniprot.org/uniprot/A0A096NSF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:ACADSB ^@ http://purl.uniprot.org/uniprot/A0A2I3NGN6 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9555:LRP6 ^@ http://purl.uniprot.org/uniprot/A0A096N517 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LDLR family.|||Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes.|||Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:SMPX ^@ http://purl.uniprot.org/uniprot/A0A096MU91 ^@ Function|||Similarity ^@ Belongs to the SMPX family.|||Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair. http://togogenome.org/gene/9555:SLC35B4 ^@ http://purl.uniprot.org/uniprot/A0A096NZN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/9555:SLC9A2 ^@ http://purl.uniprot.org/uniprot/A0A096NF26 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Interacts with CHP1 and CHP2.|||Membrane http://togogenome.org/gene/9555:ATP6V0A2 ^@ http://purl.uniprot.org/uniprot/A0A096N771 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/9555:ANP32B ^@ http://purl.uniprot.org/uniprot/A0A096P131 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANP32 family.|||Multifunctional protein that is involved in the regulation of many processes.|||Nucleus http://togogenome.org/gene/9555:OTX2 ^@ http://purl.uniprot.org/uniprot/A0A096NVA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9555:DNAJB12 ^@ http://purl.uniprot.org/uniprot/A0A096P4R2 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:YAF2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LR89|||http://purl.uniprot.org/uniprot/A0A2I3NC19 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:IL1A ^@ http://purl.uniprot.org/uniprot/A0A2I3LTT5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-1 family.|||Cytoplasm|||Monomer.|||Nucleus|||Secreted http://togogenome.org/gene/9555:MFAP5 ^@ http://purl.uniprot.org/uniprot/A0A2I3MPU3|||http://purl.uniprot.org/uniprot/A0A8I5ND55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MFAP family.|||extracellular matrix http://togogenome.org/gene/9555:MRPL27 ^@ http://purl.uniprot.org/uniprot/A0A2I3N0C6 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/9555:CBX8 ^@ http://purl.uniprot.org/uniprot/A0A8I5N260 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:SEM1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NNG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DSS1/SEM1 family.|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.|||Nucleus http://togogenome.org/gene/9555:HNF1B ^@ http://purl.uniprot.org/uniprot/A0A2I3N8U8|||http://purl.uniprot.org/uniprot/A0A2I3NCB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HNF1 homeobox family.|||Nucleus http://togogenome.org/gene/9555:GGT7 ^@ http://purl.uniprot.org/uniprot/A0A096NUR6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyltransferase family.|||Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.|||Membrane http://togogenome.org/gene/9555:DYNC1LI2 ^@ http://purl.uniprot.org/uniprot/A0A096NJ78 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.|||Belongs to the dynein light intermediate chain family.|||Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).|||cytoskeleton http://togogenome.org/gene/9555:ZSCAN2 ^@ http://purl.uniprot.org/uniprot/A0A096NN20 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:PSPH ^@ http://purl.uniprot.org/uniprot/A0A2I3MNK5 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. SerB family. http://togogenome.org/gene/9555:PHKB ^@ http://purl.uniprot.org/uniprot/A0A2I3LIY6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphorylase b kinase regulatory chain family.|||Cell membrane|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.|||Membrane|||Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. http://togogenome.org/gene/9555:BACE2 ^@ http://purl.uniprot.org/uniprot/A0A096NIY2|||http://purl.uniprot.org/uniprot/A0A096NIY9|||http://purl.uniprot.org/uniprot/A0A2I3NFQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Belongs to the peptidase A1 family.|||Endosome|||Membrane|||Secreted http://togogenome.org/gene/9555:SLC7A5 ^@ http://purl.uniprot.org/uniprot/A0A096N2R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:ACTR8 ^@ http://purl.uniprot.org/uniprot/A0A096N8J6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the actin family. ARP8 subfamily.|||Chromosome|||Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core.|||Nucleus|||Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.|||Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. http://togogenome.org/gene/9555:LHPP ^@ http://purl.uniprot.org/uniprot/A0A096NU58|||http://purl.uniprot.org/uniprot/A0A2I3LXS2 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/9555:TIGD7 ^@ http://purl.uniprot.org/uniprot/A0A096NLB6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:RPRD1B ^@ http://purl.uniprot.org/uniprot/A0A096NXG4 ^@ Function|||Similarity|||Subunit ^@ Associates with the RNA polymerase II complex.|||Belongs to the UPF0400 (RTT103) family.|||Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. http://togogenome.org/gene/9555:LOC101013243 ^@ http://purl.uniprot.org/uniprot/A0A096P5M6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9555:EMX1 ^@ http://purl.uniprot.org/uniprot/A0A096N253 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:CBR3 ^@ http://purl.uniprot.org/uniprot/A0A096NJ71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm http://togogenome.org/gene/9555:LOC101004439 ^@ http://purl.uniprot.org/uniprot/A0A8I5NI93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:LOC103877723 ^@ http://purl.uniprot.org/uniprot/B6CZ49 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:GPN2 ^@ http://purl.uniprot.org/uniprot/A0A096NQP0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/9555:MED14 ^@ http://purl.uniprot.org/uniprot/A0A2I3MKA2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 14 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9555:PXMP4 ^@ http://purl.uniprot.org/uniprot/A0A096NUU3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Interacts with PEX19.|||Peroxisome membrane http://togogenome.org/gene/9555:LOC101010515 ^@ http://purl.uniprot.org/uniprot/A0A2I3MZM8 ^@ Subunit ^@ Monomer. http://togogenome.org/gene/9555:LXN ^@ http://purl.uniprot.org/uniprot/A0A096N686 ^@ Similarity ^@ Belongs to the protease inhibitor I47 (latexin) family. http://togogenome.org/gene/9555:DEDD2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MP38 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9555:CHM ^@ http://purl.uniprot.org/uniprot/A0A8I5NXN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. http://togogenome.org/gene/9555:TMEM184B ^@ http://purl.uniprot.org/uniprot/A0A096NK12|||http://purl.uniprot.org/uniprot/A0A096NK13 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:VTI1B ^@ http://purl.uniprot.org/uniprot/A0A096NVQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/9555:SPICE1 ^@ http://purl.uniprot.org/uniprot/A0A096NUB1|||http://purl.uniprot.org/uniprot/A0A2I3MX27 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with CEP120.|||centriole|||spindle http://togogenome.org/gene/9555:ZEB1 ^@ http://purl.uniprot.org/uniprot/A0A096P409|||http://purl.uniprot.org/uniprot/A0A2I3LM14 ^@ Similarity ^@ Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family. http://togogenome.org/gene/9555:TSPAN9 ^@ http://purl.uniprot.org/uniprot/A0A8I5N7I4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9555:MAP6 ^@ http://purl.uniprot.org/uniprot/A0A8I5NZJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STOP family.|||cytoskeleton http://togogenome.org/gene/9555:PPP4R3A ^@ http://purl.uniprot.org/uniprot/A0A096NRI3 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/9555:IFNAR1 ^@ http://purl.uniprot.org/uniprot/A0A096NZP7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II cytokine receptor family.|||Cell membrane|||Endosome|||Heterodimer with IFNAR2.|||Late endosome|||Lysosome|||Membrane|||Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway. http://togogenome.org/gene/9555:FOXP4 ^@ http://purl.uniprot.org/uniprot/A8MN23 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:PPA2 ^@ http://purl.uniprot.org/uniprot/A0A096MN84 ^@ Similarity ^@ Belongs to the PPase family. http://togogenome.org/gene/9555:RSPO1 ^@ http://purl.uniprot.org/uniprot/A0A096MU32 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/9555:LOC101003499 ^@ http://purl.uniprot.org/uniprot/A0A096NHN9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit C family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm|||Phosphorylated. Phosphorylation is enhanced upon serum stimulation. http://togogenome.org/gene/9555:IL1B ^@ http://purl.uniprot.org/uniprot/A0A2I3N9K4 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-1 family.|||IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.|||Lysosome|||Monomer. Interacts with MEFV.|||Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.|||Secreted|||cytosol|||extracellular exosome http://togogenome.org/gene/9555:CDKN2AIPNL ^@ http://purl.uniprot.org/uniprot/A0A096N5T4 ^@ Similarity ^@ Belongs to the CARF family. http://togogenome.org/gene/9555:FUT9 ^@ http://purl.uniprot.org/uniprot/A0A096MLI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9555:DLGAP4 ^@ http://purl.uniprot.org/uniprot/A0A2I3MTV2 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/9555:ARSG ^@ http://purl.uniprot.org/uniprot/A0A096NU03 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9555:ACTL10 ^@ http://purl.uniprot.org/uniprot/A0A096N915 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9555:HOXA10 ^@ http://purl.uniprot.org/uniprot/A9L943 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9555:DNAJA4 ^@ http://purl.uniprot.org/uniprot/A0A2I3LY88 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:MYF6 ^@ http://purl.uniprot.org/uniprot/A0A8I5NKC1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:COQ6 ^@ http://purl.uniprot.org/uniprot/A0A096NUG4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UbiH/COQ6 family.|||Cell projection|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ7.|||FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.|||Golgi apparatus|||Mitochondrion inner membrane http://togogenome.org/gene/9555:CDR2L ^@ http://purl.uniprot.org/uniprot/A0A096NST1 ^@ Similarity ^@ Belongs to the CDR2 family. http://togogenome.org/gene/9555:PDE1B ^@ http://purl.uniprot.org/uniprot/A0A096NAN6|||http://purl.uniprot.org/uniprot/A0A2I3MQ92 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9555:FAM102A ^@ http://purl.uniprot.org/uniprot/A0A096P1Y9 ^@ Similarity ^@ Belongs to the EEIG family. http://togogenome.org/gene/9555:LOC103880462 ^@ http://purl.uniprot.org/uniprot/A0A8I5MVK6 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9555:SLC37A1 ^@ http://purl.uniprot.org/uniprot/A0A096NIT6|||http://purl.uniprot.org/uniprot/A0A2I3N849 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.|||Membrane http://togogenome.org/gene/9555:TMCO5A ^@ http://purl.uniprot.org/uniprot/A0A8I5R956 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:CD68 ^@ http://purl.uniprot.org/uniprot/A0A096P2R1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9555:TMEM80 ^@ http://purl.uniprot.org/uniprot/A0A096MRI5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:CNOT10 ^@ http://purl.uniprot.org/uniprot/A0A096NQB5|||http://purl.uniprot.org/uniprot/A0A2I3LYP6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT10 family.|||Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:UGDH ^@ http://purl.uniprot.org/uniprot/A0A096MY79 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.|||Homohexamer.|||Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. http://togogenome.org/gene/9555:TRAPPC3 ^@ http://purl.uniprot.org/uniprot/A0A096N7N5|||http://purl.uniprot.org/uniprot/A0A2I3N4V5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||Homodimer.|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||cis-Golgi network http://togogenome.org/gene/9555:MTM1 ^@ http://purl.uniprot.org/uniprot/A0A096MWN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/9555:ARMCX1 ^@ http://purl.uniprot.org/uniprot/A0A096N6K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eutherian X-chromosome-specific Armcx family.|||Membrane http://togogenome.org/gene/9555:PARP12 ^@ http://purl.uniprot.org/uniprot/A0A096NG88 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9555:LOC101020893 ^@ http://purl.uniprot.org/uniprot/A0A096NFZ7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:CACNG3 ^@ http://purl.uniprot.org/uniprot/A0A2I3M816 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane http://togogenome.org/gene/9555:RENBP ^@ http://purl.uniprot.org/uniprot/A9CB51 ^@ Similarity ^@ Belongs to the N-acylglucosamine 2-epimerase family. http://togogenome.org/gene/9555:SERP1 ^@ http://purl.uniprot.org/uniprot/A0A096MUM4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAMP4 family.|||Endoplasmic reticulum membrane|||May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.|||Membrane http://togogenome.org/gene/9555:ND1 ^@ http://purl.uniprot.org/uniprot/K9MVJ3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 1 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:LOC101008370 ^@ http://purl.uniprot.org/uniprot/A0A096NZY9 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family. Plasminogen subfamily.|||Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.|||Secreted http://togogenome.org/gene/9555:PPM1A ^@ http://purl.uniprot.org/uniprot/A0A096NVG4|||http://purl.uniprot.org/uniprot/A0A2I3N2T6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PP2C family.|||Membrane|||cytosol http://togogenome.org/gene/9555:BRINP3 ^@ http://purl.uniprot.org/uniprot/A0A096NAE1 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/9555:KPNA3 ^@ http://purl.uniprot.org/uniprot/A0A096N604 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9555:GHRL ^@ http://purl.uniprot.org/uniprot/E7CH27 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the motilin family.|||Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.|||O-octanoylation is essential for ghrelin activity.|||Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.|||Secreted http://togogenome.org/gene/9555:NKX1-1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LYB3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:MIS12 ^@ http://purl.uniprot.org/uniprot/A0A8I5MXW4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mis12 family.|||Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3, CBX5, NDC80 and ZWINT.|||kinetochore http://togogenome.org/gene/9555:LOC101022949 ^@ http://purl.uniprot.org/uniprot/A0A096MKX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9555:TNFSF10 ^@ http://purl.uniprot.org/uniprot/A0A096MXB8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Homotrimer.|||Membrane|||Secreted http://togogenome.org/gene/9555:LPAR6 ^@ http://purl.uniprot.org/uniprot/A0A096N7C3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9555:TIMM23 ^@ http://purl.uniprot.org/uniprot/A0A2I3N5I5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:PHETA2 ^@ http://purl.uniprot.org/uniprot/A0A8I5MV03 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sesquipedalian family.|||Early endosome|||Forms homodimers and heterodimers with PHETA. Interacts with OCRL and INPP5B.|||Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.|||Recycling endosome|||clathrin-coated vesicle|||trans-Golgi network http://togogenome.org/gene/9555:CHST4 ^@ http://purl.uniprot.org/uniprot/A0A096MUE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/9555:XRN2 ^@ http://purl.uniprot.org/uniprot/A0A096NVR5|||http://purl.uniprot.org/uniprot/A0A8I5R7R6 ^@ Function|||Similarity ^@ Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.|||Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. http://togogenome.org/gene/9555:FZD2 ^@ http://purl.uniprot.org/uniprot/A0A096P631 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:NIPAL2 ^@ http://purl.uniprot.org/uniprot/A0A096MY67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9555:ISL1 ^@ http://purl.uniprot.org/uniprot/A0A8I5N5M7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:PAQR7 ^@ http://purl.uniprot.org/uniprot/A0A096NA51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9555:QTRT2 ^@ http://purl.uniprot.org/uniprot/A0A8I5N579 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.|||Mitochondrion outer membrane|||Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). http://togogenome.org/gene/9555:EEF1D ^@ http://purl.uniprot.org/uniprot/A0A2I3MRW2|||http://purl.uniprot.org/uniprot/A0A2I3NGW7 ^@ Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family. http://togogenome.org/gene/9555:STX4 ^@ http://purl.uniprot.org/uniprot/A0A096NHX2 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9555:SNX30 ^@ http://purl.uniprot.org/uniprot/A0A096P0U9 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9555:SF3A3 ^@ http://purl.uniprot.org/uniprot/A0A096MMW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3A3 family.|||Nucleus http://togogenome.org/gene/9555:TUBB4B ^@ http://purl.uniprot.org/uniprot/A0A2I3LVF9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9555:ST8SIA1 ^@ http://purl.uniprot.org/uniprot/A0A096MUX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9555:SLC48A1 ^@ http://purl.uniprot.org/uniprot/A0A096MVI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HRG family.|||Endosome membrane|||Membrane|||phagosome membrane http://togogenome.org/gene/9555:IL18R1 ^@ http://purl.uniprot.org/uniprot/A0A096NUE8 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9555:CTU2 ^@ http://purl.uniprot.org/uniprot/A0A096NWH6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTU2/NCS2 family.|||Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.|||Cytoplasm|||Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. http://togogenome.org/gene/9555:BTF3 ^@ http://purl.uniprot.org/uniprot/A0A2I3MAR5 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/9555:UBL3 ^@ http://purl.uniprot.org/uniprot/A0A096MWS6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9555:GTPBP4 ^@ http://purl.uniprot.org/uniprot/A0A096P371|||http://purl.uniprot.org/uniprot/A0A2I3N180 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.|||Involved in the biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/9555:LZIC ^@ http://purl.uniprot.org/uniprot/A0A096NA05 ^@ Similarity ^@ Belongs to the CTNNBIP1 family. http://togogenome.org/gene/9555:PROX1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NJ29 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:THOC5 ^@ http://purl.uniprot.org/uniprot/A0A096NJE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the THOC5 family.|||Nucleus http://togogenome.org/gene/9555:LOC103883684 ^@ http://purl.uniprot.org/uniprot/A0A8I5NDN0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.|||Vacuole membrane|||clathrin-coated vesicle membrane|||synaptic vesicle membrane http://togogenome.org/gene/9555:GALNTL5 ^@ http://purl.uniprot.org/uniprot/A0A096N9W9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Membrane http://togogenome.org/gene/9555:LOC101022655 ^@ http://purl.uniprot.org/uniprot/A0A8I5N7P9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM134/TMEM230 family.|||Early endosome|||Endosome|||Involved in trafficking and recycling of synaptic vesicles.|||Late endosome|||Membrane|||Recycling endosome|||autophagosome|||synaptic vesicle|||trans-Golgi network http://togogenome.org/gene/9555:HNRNPR ^@ http://purl.uniprot.org/uniprot/A0A096MZV5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:MARF1 ^@ http://purl.uniprot.org/uniprot/A0A096NLV4 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/9555:DBX1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LQY1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:D2HGDH ^@ http://purl.uniprot.org/uniprot/A0A096N2N2 ^@ Similarity ^@ Belongs to the FAD-binding oxidoreductase/transferase type 4 family. http://togogenome.org/gene/9555:INHA ^@ http://purl.uniprot.org/uniprot/B0CM57 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.|||Secreted http://togogenome.org/gene/9555:UPK1B ^@ http://purl.uniprot.org/uniprot/A0A096MRT9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:SAXO1 ^@ http://purl.uniprot.org/uniprot/A0A096P1H2 ^@ Similarity ^@ Belongs to the FAM154 family. http://togogenome.org/gene/9555:IL13 ^@ http://purl.uniprot.org/uniprot/A9CB12 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-4/IL-13 family.|||Interacts with IL13RA2.|||Secreted http://togogenome.org/gene/9555:RTN4 ^@ http://purl.uniprot.org/uniprot/A0A096N0R3|||http://purl.uniprot.org/uniprot/A0A096NZN7|||http://purl.uniprot.org/uniprot/A0A2I3NF09 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:MYT1L ^@ http://purl.uniprot.org/uniprot/A0A096NIK8|||http://purl.uniprot.org/uniprot/A0A2I3LNX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYT1 family.|||Nucleus http://togogenome.org/gene/9555:TXNL4B ^@ http://purl.uniprot.org/uniprot/A0A096NGW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/9555:HMGN3 ^@ http://purl.uniprot.org/uniprot/A0A2I3N3M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/9555:NAA10 ^@ http://purl.uniprot.org/uniprot/A9CB50 ^@ Similarity ^@ Belongs to the acetyltransferase family. ARD1 subfamily. http://togogenome.org/gene/9555:AZIN1 ^@ http://purl.uniprot.org/uniprot/A0A096N329 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/9555:VCP ^@ http://purl.uniprot.org/uniprot/A0A096P194 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9555:MPV17L2 ^@ http://purl.uniprot.org/uniprot/A0A0A0MX81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/9555:C7H15orf40 ^@ http://purl.uniprot.org/uniprot/A0A2I3NG97 ^@ Similarity ^@ Belongs to the UPF0235 family. http://togogenome.org/gene/9555:CLCN2 ^@ http://purl.uniprot.org/uniprot/A0A2I3M457 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:GPHA2 ^@ http://purl.uniprot.org/uniprot/B0CM72 ^@ Caution|||Similarity ^@ Belongs to the glycoprotein hormones subunit alpha family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:FLVCR2 ^@ http://purl.uniprot.org/uniprot/A0A096NS55 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:RUNX3 ^@ http://purl.uniprot.org/uniprot/A0A096NWX7 ^@ Function|||Subcellular Location Annotation ^@ Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.|||Nucleus http://togogenome.org/gene/9555:FMNL3 ^@ http://purl.uniprot.org/uniprot/A0A2I3LEM0 ^@ Similarity ^@ Belongs to the formin homology family. http://togogenome.org/gene/9555:CAPZB ^@ http://purl.uniprot.org/uniprot/A0A096MVM8|||http://purl.uniprot.org/uniprot/A0A2I3NEQ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the F-actin-capping protein beta subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit.|||cytoskeleton|||sarcomere http://togogenome.org/gene/9555:CAPZA1 ^@ http://purl.uniprot.org/uniprot/A0A096NE85 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/9555:ATP1B4 ^@ http://purl.uniprot.org/uniprot/A0A096N5U5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9555:KIF5B ^@ http://purl.uniprot.org/uniprot/A0A096P421 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9555:COG6 ^@ http://purl.uniprot.org/uniprot/A0A096N295 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COG6 family.|||Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.|||Golgi apparatus membrane|||Membrane|||Required for normal Golgi function. http://togogenome.org/gene/9555:NRG2 ^@ http://purl.uniprot.org/uniprot/A0A2I3M800|||http://purl.uniprot.org/uniprot/A0A2I3MG57 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neuregulin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9555:CDK2 ^@ http://purl.uniprot.org/uniprot/A0A096MYH8|||http://purl.uniprot.org/uniprot/A0A2I3MV08 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:KIF3A ^@ http://purl.uniprot.org/uniprot/A9CB14 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9555:MSMP ^@ http://purl.uniprot.org/uniprot/A0A096P171 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-microseminoprotein family.|||Secreted http://togogenome.org/gene/9555:AURKAIP1 ^@ http://purl.uniprot.org/uniprot/A0A096MZK4 ^@ Similarity ^@ Belongs to the mitochondrion-specific ribosomal protein mS38 family. http://togogenome.org/gene/9555:RPL37 ^@ http://purl.uniprot.org/uniprot/A0A2I3N5I0 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/9555:MEP1A ^@ http://purl.uniprot.org/uniprot/A0A096NIV6 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:TXLNG ^@ http://purl.uniprot.org/uniprot/A0A8I5ND34 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/9555:MCCC2 ^@ http://purl.uniprot.org/uniprot/A0A096NBM9 ^@ Similarity ^@ Belongs to the AccD/PCCB family. http://togogenome.org/gene/9555:PGC ^@ http://purl.uniprot.org/uniprot/A0A2I3MH01|||http://purl.uniprot.org/uniprot/A8MN26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Secreted http://togogenome.org/gene/9555:SERPINB12 ^@ http://purl.uniprot.org/uniprot/A9RA89 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9555:AKAP8L ^@ http://purl.uniprot.org/uniprot/A0A0A0MW70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AKAP95 family.|||Nucleus matrix http://togogenome.org/gene/9555:DAP3 ^@ http://purl.uniprot.org/uniprot/A0A8I5NV99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS29 family.|||Mitochondrion http://togogenome.org/gene/9555:PSMD2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MC55 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S2 family.|||Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. http://togogenome.org/gene/9555:LOC101001693 ^@ http://purl.uniprot.org/uniprot/A0A2I3LM58 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. http://togogenome.org/gene/9555:SERPINB6 ^@ http://purl.uniprot.org/uniprot/A0A8I5NST9 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9555:CYLD ^@ http://purl.uniprot.org/uniprot/A0A2I3MES0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||centrosome|||cilium basal body|||perinuclear region|||spindle http://togogenome.org/gene/9555:ACOT8 ^@ http://purl.uniprot.org/uniprot/A0A096NX31 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/9555:SGK1 ^@ http://purl.uniprot.org/uniprot/A0A2I3M8F8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:ZNF687 ^@ http://purl.uniprot.org/uniprot/A0A2I3N352|||http://purl.uniprot.org/uniprot/A0A8J8YKM2|||http://purl.uniprot.org/uniprot/A9X199 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9555:TIMM21 ^@ http://purl.uniprot.org/uniprot/A0A8I5QZR1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM21 family.|||Component of the TIM23 complex.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion membrane|||Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes. http://togogenome.org/gene/9555:TMEM50B ^@ http://purl.uniprot.org/uniprot/A9CAZ8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UPF0220 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||May form homotrimers or homodimers. http://togogenome.org/gene/9555:LOC101005856 ^@ http://purl.uniprot.org/uniprot/A0A096NX20 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9555:SPAST ^@ http://purl.uniprot.org/uniprot/A0A096NFG3|||http://purl.uniprot.org/uniprot/A0A2I3NAE6 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex. Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex. Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling. Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing. Probably plays a role in axon growth and the formation of axonal branches.|||Allosteric enzyme with a cooperative mechanism; at least two neighbor subunits influence each other strongly in spastin hexamers. Microtubule binding promotes cooperative interactions among spastin subunits.|||Belongs to the AAA ATPase family. Spastin subfamily.|||Cytoplasm|||Endoplasmic reticulum|||Homohexamer. Mostly monomeric, but assembles into hexameric structure for short periods of time. Oligomerization seems to be a prerequisite for catalytic activity. Binding to ATP in a cleft between two adjacent subunits stabilizes the homohexameric form. Binds to microtubules at least in part via the alpha-tubulin and beta-tubulin tails. The hexamer adopts a ring conformation through which microtubules pass prior to being severed. Does not interact strongly with tubulin heterodimers. Interacts (via MIT domain) with CHMP1B; the interaction is direct. Interacts with SSNA1. Interacts with ATL1. Interacts with RTN1. Interacts with ZFYVE27. Interacts with REEP1. Interacts (via MIT domain) with IST1.|||Membrane|||Midbody|||Nucleus|||axon|||centrosome|||cytoskeleton|||perinuclear region|||spindle http://togogenome.org/gene/9555:RPL13 ^@ http://purl.uniprot.org/uniprot/A0A2I3MG94 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL13 family. http://togogenome.org/gene/9555:MPDU1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LMT0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MPDU1 (TC 2.A.43.3) family.|||Membrane|||Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors. http://togogenome.org/gene/9555:FAM135A ^@ http://purl.uniprot.org/uniprot/A0A2I3M8F9|||http://purl.uniprot.org/uniprot/A0A2I3MXX5|||http://purl.uniprot.org/uniprot/A0A8I5R9S3 ^@ Similarity ^@ Belongs to the FAM135 family. http://togogenome.org/gene/9555:TEX261 ^@ http://purl.uniprot.org/uniprot/A0A096NW02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SVP26 family.|||Membrane http://togogenome.org/gene/9555:FAXC ^@ http://purl.uniprot.org/uniprot/A0A2I3MCA6 ^@ Similarity ^@ Belongs to the FAX family. http://togogenome.org/gene/9555:PAX6 ^@ http://purl.uniprot.org/uniprot/A0A096N4Y7|||http://purl.uniprot.org/uniprot/A0A2I3MV39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/9555:TMTC3 ^@ http://purl.uniprot.org/uniprot/A0A2I3MLN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/9555:TCP10L ^@ http://purl.uniprot.org/uniprot/A9CAY8 ^@ Similarity ^@ Belongs to the TCP10 family. http://togogenome.org/gene/9555:CLUAP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LXR9|||http://purl.uniprot.org/uniprot/A0A2I3MC02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLUAP1 family.|||cilium http://togogenome.org/gene/9555:LOC101024012 ^@ http://purl.uniprot.org/uniprot/A0A096MZA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/9555:DBNDD1 ^@ http://purl.uniprot.org/uniprot/A0A096NR46 ^@ Similarity ^@ Belongs to the dysbindin family. http://togogenome.org/gene/9555:RAMAC ^@ http://purl.uniprot.org/uniprot/A0A096NN08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAM family.|||Nucleus http://togogenome.org/gene/9555:DRD1 ^@ http://purl.uniprot.org/uniprot/A0A096MZY6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.|||Membrane|||dendritic spine http://togogenome.org/gene/9555:MRPL47 ^@ http://purl.uniprot.org/uniprot/A0A096N724|||http://purl.uniprot.org/uniprot/A0A2I3N5C8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/9555:PISD ^@ http://purl.uniprot.org/uniprot/A0A096NJM9|||http://purl.uniprot.org/uniprot/A9CB35 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.|||Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:TRIM68 ^@ http://purl.uniprot.org/uniprot/A0A096MQG9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9555:LOC101021752 ^@ http://purl.uniprot.org/uniprot/A0A8I5NDM8 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9555:TGFBR2 ^@ http://purl.uniprot.org/uniprot/A0A096N140|||http://purl.uniprot.org/uniprot/A0A2I3N4N9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Cell membrane|||Membrane|||Membrane raft|||Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. http://togogenome.org/gene/9555:PPP4R3B ^@ http://purl.uniprot.org/uniprot/A0A2I3LF90|||http://purl.uniprot.org/uniprot/A0A2I3MML1 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/9555:NDUFB6 ^@ http://purl.uniprot.org/uniprot/A0A096P1D6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB6 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:GPC3 ^@ http://purl.uniprot.org/uniprot/A0A2I3MI34 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/9555:SEMA4D ^@ http://purl.uniprot.org/uniprot/A0A096P1Y1 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:GADD45B ^@ http://purl.uniprot.org/uniprot/A0A0A0MX24 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/9555:FITM1 ^@ http://purl.uniprot.org/uniprot/A0A096NX71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FIT family. FIT1 subfamily.|||Endoplasmic reticulum membrane|||Membrane|||Plays an important role in the formation of lipid droplets (LDs), which are storage organelles at the center of lipid and energy homeostasis. Directly binds to diacylglycerol (DAGs) and triacylglycerol. http://togogenome.org/gene/9555:CDH24 ^@ http://purl.uniprot.org/uniprot/A0A096NWI7 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:SEC61A1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MXU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:ALDH1A1 ^@ http://purl.uniprot.org/uniprot/A0A096P1S3 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9555:LOC100998789 ^@ http://purl.uniprot.org/uniprot/A0A096MMX9 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9555:STK32B ^@ http://purl.uniprot.org/uniprot/A0A096NZD4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:S100G ^@ http://purl.uniprot.org/uniprot/A0A096MUK9 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9555:LOC101022919 ^@ http://purl.uniprot.org/uniprot/A0A8I5R8F3 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/9555:CPLX3 ^@ http://purl.uniprot.org/uniprot/A0A096NMR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9555:TARS1 ^@ http://purl.uniprot.org/uniprot/A0A2I3ML49 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9555:ATPAF1 ^@ http://purl.uniprot.org/uniprot/A0A096NYR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP11 family.|||Mitochondrion http://togogenome.org/gene/9555:MOB3C ^@ http://purl.uniprot.org/uniprot/A0A096MZF7 ^@ Similarity ^@ Belongs to the MOB1/phocein family. http://togogenome.org/gene/9555:SPTY2D1 ^@ http://purl.uniprot.org/uniprot/A0A096N3G5 ^@ Similarity ^@ Belongs to the SPT2 family. http://togogenome.org/gene/9555:HRH1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LV21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:CCT2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MAV7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.|||Cytoplasm http://togogenome.org/gene/9555:SMG8 ^@ http://purl.uniprot.org/uniprot/A0A096P4W1 ^@ Function|||Similarity ^@ Belongs to the SMG8 family.|||Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. http://togogenome.org/gene/9555:ACTA2 ^@ http://purl.uniprot.org/uniprot/A0A096P5E0 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9555:MARK2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MTJ8|||http://purl.uniprot.org/uniprot/A0A2I3MV99|||http://purl.uniprot.org/uniprot/A0A2I3N614 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||dendrite http://togogenome.org/gene/9555:AMZ2 ^@ http://purl.uniprot.org/uniprot/A0A096NU01 ^@ Function|||Similarity ^@ Belongs to the peptidase M54 family.|||Probable zinc metalloprotease. http://togogenome.org/gene/9555:DKK1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NDC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/9555:GAPDH ^@ http://purl.uniprot.org/uniprot/A0A096NGN6 ^@ Similarity|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/9555:TFPI ^@ http://purl.uniprot.org/uniprot/A0A096N566|||http://purl.uniprot.org/uniprot/A0A2I3NCR2 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9555:LOC101000499 ^@ http://purl.uniprot.org/uniprot/A0A096NEC7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:TFCP2 ^@ http://purl.uniprot.org/uniprot/A0A096N7Y9|||http://purl.uniprot.org/uniprot/A0A2I3NHB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus http://togogenome.org/gene/9555:MTX3 ^@ http://purl.uniprot.org/uniprot/A0A096MN96|||http://purl.uniprot.org/uniprot/A0A2I3MPU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metaxin family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9555:TNP2 ^@ http://purl.uniprot.org/uniprot/A0A096NLP3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear transition protein 2 family.|||Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.|||nucleolus http://togogenome.org/gene/9555:DCLK1 ^@ http://purl.uniprot.org/uniprot/A0A096MPC6|||http://purl.uniprot.org/uniprot/A0A2I3MBU0|||http://purl.uniprot.org/uniprot/A0A2I3MD97 ^@ Similarity ^@ Belongs to the protein kinase superfamily.|||Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9555:SAP18 ^@ http://purl.uniprot.org/uniprot/A0A096NFK1 ^@ Similarity ^@ Belongs to the SAP18 family. http://togogenome.org/gene/9555:PPP2CB ^@ http://purl.uniprot.org/uniprot/A0A096N3J6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/9555:AIDA ^@ http://purl.uniprot.org/uniprot/A0A096MZU2 ^@ Similarity ^@ Belongs to the AIDA family. http://togogenome.org/gene/9555:CDX2 ^@ http://purl.uniprot.org/uniprot/A0A8I5R839 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Caudal homeobox family.|||Nucleus http://togogenome.org/gene/9555:USB1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MDI6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 2H phosphoesterase superfamily. USB1 family.|||Nucleus|||Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. http://togogenome.org/gene/9555:NR0B1 ^@ http://purl.uniprot.org/uniprot/A0A096MPW2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR0 subfamily.|||Cytoplasm|||Nucleus|||Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency. http://togogenome.org/gene/9555:NEU2 ^@ http://purl.uniprot.org/uniprot/A0A096NQR0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/9555:LOC101023020 ^@ http://purl.uniprot.org/uniprot/A0A096NRD9 ^@ Similarity ^@ Belongs to the HPF1 family. http://togogenome.org/gene/9555:ESS2 ^@ http://purl.uniprot.org/uniprot/A0A096NS10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESS2 family.|||Nucleus http://togogenome.org/gene/9555:SCAMP4 ^@ http://purl.uniprot.org/uniprot/A0A2I3MRF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/9555:MED26 ^@ http://purl.uniprot.org/uniprot/A0A2I3MXE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 26 family.|||Nucleus http://togogenome.org/gene/9555:SEMA3F ^@ http://purl.uniprot.org/uniprot/A0A096MY22|||http://purl.uniprot.org/uniprot/A0A096N5L3 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:IL1R1 ^@ http://purl.uniprot.org/uniprot/A0A096NU91 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9555:NFIL3 ^@ http://purl.uniprot.org/uniprot/A0A096N905 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. Protects pro-B cells from programmed cell death.|||Belongs to the bZIP family. NFIL3 subfamily.|||Homodimer. Binds DNA as a dimer.|||Nucleus http://togogenome.org/gene/9555:SAMD8 ^@ http://purl.uniprot.org/uniprot/A0A096P4J5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/9555:TMBIM4 ^@ http://purl.uniprot.org/uniprot/A0A2I3LHX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9555:SEC61G ^@ http://purl.uniprot.org/uniprot/A0A096NF01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecE/SEC61-gamma family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:LSM6 ^@ http://purl.uniprot.org/uniprot/A0A8I5NAA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/9555:CLPP ^@ http://purl.uniprot.org/uniprot/A0A8I5N433 ^@ Similarity ^@ Belongs to the peptidase S14 family. http://togogenome.org/gene/9555:LOC101019230 ^@ http://purl.uniprot.org/uniprot/A0A8I5NI10 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9555:NCAPH2 ^@ http://purl.uniprot.org/uniprot/A0A096NL50 ^@ Similarity ^@ Belongs to the CND2 H2 (condensin-2 subunit 2) family. http://togogenome.org/gene/9555:RPS6KA5 ^@ http://purl.uniprot.org/uniprot/A0A2I3MGX6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9555:NSMCE2 ^@ http://purl.uniprot.org/uniprot/A0A096NFK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NSE2 family.|||Nucleus http://togogenome.org/gene/9555:LOC101018174 ^@ http://purl.uniprot.org/uniprot/A0A096N7J3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:GRK4 ^@ http://purl.uniprot.org/uniprot/A0A096NRE3|||http://purl.uniprot.org/uniprot/A0A096NU73|||http://purl.uniprot.org/uniprot/A0A2I3LMC4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9555:SIAH1 ^@ http://purl.uniprot.org/uniprot/A0A096NI55 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/9555:HSD17B2 ^@ http://purl.uniprot.org/uniprot/A0A096NPH6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9555:RAB11FIP4 ^@ http://purl.uniprot.org/uniprot/A0A096P3P5 ^@ Subcellular Location Annotation ^@ Cleavage furrow|||Endosome membrane|||Membrane|||Midbody|||Recycling endosome membrane http://togogenome.org/gene/9555:DEFB125 ^@ http://purl.uniprot.org/uniprot/A0A2I3N7D2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9555:LOC101000271 ^@ http://purl.uniprot.org/uniprot/A0A096NHZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 6A family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:TNFRSF19 ^@ http://purl.uniprot.org/uniprot/A0A096N9Q0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:ABI2 ^@ http://purl.uniprot.org/uniprot/A0A096MZ16|||http://purl.uniprot.org/uniprot/A0A2I3ND82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABI family.|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/9555:CCR5 ^@ http://purl.uniprot.org/uniprot/Q9XT13 ^@ Similarity|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Interacts with PRAF2. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with GRK2. Interacts with ARRB1 and ARRB2. Interacts with CNIH4. Interacts with S100A4; this interaction stimulates T-lymphocyte chemotaxis. http://togogenome.org/gene/9555:FGF20 ^@ http://purl.uniprot.org/uniprot/A0A8I5NDF2 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9555:CSNK1A1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MX56|||http://purl.uniprot.org/uniprot/A0A2I3NG04|||http://purl.uniprot.org/uniprot/A0A8I5NV62 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:NR2C1 ^@ http://purl.uniprot.org/uniprot/A0A096N0J6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9555:HOXA7 ^@ http://purl.uniprot.org/uniprot/A9L941 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9555:TM4SF5 ^@ http://purl.uniprot.org/uniprot/A0A096P2G8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9555:LOC101007380 ^@ http://purl.uniprot.org/uniprot/A0A8I5QZ85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:H1-4 ^@ http://purl.uniprot.org/uniprot/A0A096NEG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9555:ATP2B4 ^@ http://purl.uniprot.org/uniprot/A0A096MSR2|||http://purl.uniprot.org/uniprot/A0A096MW85 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:MMAB ^@ http://purl.uniprot.org/uniprot/A0A8I5NRE3 ^@ Similarity ^@ Belongs to the Cob(I)alamin adenosyltransferase family. http://togogenome.org/gene/9555:CPE ^@ http://purl.uniprot.org/uniprot/A0A096MYE8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M14 family.|||Interacts with Secretogranin III/SCG3.|||Membrane|||Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage.|||secretory vesicle membrane http://togogenome.org/gene/9555:EPHA7 ^@ http://purl.uniprot.org/uniprot/A0A096NGE6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:NLGN1 ^@ http://purl.uniprot.org/uniprot/A0A096N102 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:HBG2 ^@ http://purl.uniprot.org/uniprot/A9L8X9 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9555:COPB2 ^@ http://purl.uniprot.org/uniprot/A0A096MUX9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat COPB2 family.|||COPI-coated vesicle membrane|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.|||This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner. http://togogenome.org/gene/9555:EXOSC8 ^@ http://purl.uniprot.org/uniprot/A0A096MWY6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:CISD1 ^@ http://purl.uniprot.org/uniprot/A0A8I5N867 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CISD protein family. CISD2 subfamily.|||Binds 1 [2Fe-2S] cluster.|||Endoplasmic reticulum membrane|||Homodimer.|||Mitochondrion outer membrane|||Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. http://togogenome.org/gene/9555:CACUL1 ^@ http://purl.uniprot.org/uniprot/A0A096NTW6 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9555:RAG2 ^@ http://purl.uniprot.org/uniprot/A0A096N3Y9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAG2 family.|||Nucleus http://togogenome.org/gene/9555:METAP2 ^@ http://purl.uniprot.org/uniprot/A0A096NGA3 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Binds EIF2S1 at low magnesium concentrations. Interacts strongly with the eIF-2 gamma-subunit EIF2S3.|||Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).|||Cytoplasm|||Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis. http://togogenome.org/gene/9555:PDGFRL ^@ http://purl.uniprot.org/uniprot/A0A096MZH1 ^@ Subunit ^@ Forms a complex composed of PDGFRL, TNK2 and GRB2. http://togogenome.org/gene/9555:PDCL ^@ http://purl.uniprot.org/uniprot/A0A2I3LQA2 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9555:ACTR1B ^@ http://purl.uniprot.org/uniprot/A0A096NGT7 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9555:NOTUM ^@ http://purl.uniprot.org/uniprot/A0A2I3N0V2 ^@ Similarity ^@ Belongs to the pectinacetylesterase family. Notum subfamily. http://togogenome.org/gene/9555:LOC101024278 ^@ http://purl.uniprot.org/uniprot/A0A2I3M899 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MADD family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9555:MAPK7 ^@ http://purl.uniprot.org/uniprot/A0A096P344 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9555:HARBI1 ^@ http://purl.uniprot.org/uniprot/A0A096N1S7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HARBI1 family.|||Cytoplasm|||Nucleus|||Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity. http://togogenome.org/gene/9555:MAP2K6 ^@ http://purl.uniprot.org/uniprot/A0A096NU44|||http://purl.uniprot.org/uniprot/A0A2I3LHS5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:FNBP1L ^@ http://purl.uniprot.org/uniprot/A0A2I3MJ40|||http://purl.uniprot.org/uniprot/A0A2I3MQR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNBP1 family.|||Cell membrane|||Cytoplasmic vesicle|||Membrane|||Vesicle|||cell cortex|||cytoskeleton http://togogenome.org/gene/9555:ZW10 ^@ http://purl.uniprot.org/uniprot/A0A096N1A9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZW10 family.|||kinetochore http://togogenome.org/gene/9555:MFGE8 ^@ http://purl.uniprot.org/uniprot/A0A096NN57 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:EXOSC2 ^@ http://purl.uniprot.org/uniprot/A0A096P0F8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP4 family.|||Cytoplasm http://togogenome.org/gene/9555:AP1B1 ^@ http://purl.uniprot.org/uniprot/A0A096NJD6|||http://purl.uniprot.org/uniprot/A0A2I3M8B6|||http://purl.uniprot.org/uniprot/A0A2I3MFD1 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/9555:B4GALT7 ^@ http://purl.uniprot.org/uniprot/A0A096ND10 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9555:PRPS2 ^@ http://purl.uniprot.org/uniprot/A0A2I3M8Z8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family.|||Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.|||Homodimer. The active form is probably a hexamer composed of 3 homodimers. http://togogenome.org/gene/9555:RAB3D ^@ http://purl.uniprot.org/uniprot/A0A2I3MXN8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/9555:APOO ^@ http://purl.uniprot.org/uniprot/A0A096MU27 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:GGACT ^@ http://purl.uniprot.org/uniprot/A0A8I5NWB1 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family.|||Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. http://togogenome.org/gene/9555:SH3GL2 ^@ http://purl.uniprot.org/uniprot/A0A096P1H4|||http://purl.uniprot.org/uniprot/A0A2I3MK86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Membrane http://togogenome.org/gene/9555:AGT ^@ http://purl.uniprot.org/uniprot/A0A096N678 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the serpin family.|||Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.|||Secreted|||Stimulates aldosterone release. http://togogenome.org/gene/9555:PSMD11 ^@ http://purl.uniprot.org/uniprot/A0A096P3S8 ^@ Similarity ^@ Belongs to the proteasome subunit S9 family. http://togogenome.org/gene/9555:CLDN3 ^@ http://purl.uniprot.org/uniprot/A0A096ML45 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the claudin family.|||Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9555:LDHC ^@ http://purl.uniprot.org/uniprot/A0A096N757 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/9555:SF1 ^@ http://purl.uniprot.org/uniprot/A0A096MPE2|||http://purl.uniprot.org/uniprot/A0A2I3NAC2|||http://purl.uniprot.org/uniprot/B0CM65 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BBP/SF1 family.|||Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.|||Nucleus http://togogenome.org/gene/9555:SELENBP1 ^@ http://purl.uniprot.org/uniprot/A9X1A2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the selenium-binding protein family.|||Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.|||Interacts with USP33.|||Membrane|||Nucleus|||cytosol http://togogenome.org/gene/9555:EPOR ^@ http://purl.uniprot.org/uniprot/A0A0A0MVH4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||Forms homodimers on EPO stimulation.|||Membrane|||Receptor for erythropoietin. http://togogenome.org/gene/9555:LOC101012602 ^@ http://purl.uniprot.org/uniprot/A0A096NAX8 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/9555:RPE65 ^@ http://purl.uniprot.org/uniprot/A0A096P023 ^@ Cofactor|||Similarity ^@ Belongs to the carotenoid oxygenase family.|||Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/9555:AKAP4 ^@ http://purl.uniprot.org/uniprot/A0A2I3LRN7 ^@ Similarity ^@ Belongs to the AKAP110 family. http://togogenome.org/gene/9555:SCAMP3 ^@ http://purl.uniprot.org/uniprot/A0A096MQH8|||http://purl.uniprot.org/uniprot/A0A2I3MF59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/9555:MRGBP ^@ http://purl.uniprot.org/uniprot/A0A8I5R0T9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EAF7 family.|||Nucleus http://togogenome.org/gene/9555:ZDHHC18 ^@ http://purl.uniprot.org/uniprot/A0A8I5ND44 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9555:BICD2 ^@ http://purl.uniprot.org/uniprot/A0A096P241|||http://purl.uniprot.org/uniprot/A0A8I5NTK6 ^@ Similarity ^@ Belongs to the BicD family. http://togogenome.org/gene/9555:CHMP4B ^@ http://purl.uniprot.org/uniprot/A0A096NUU1 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9555:SLC7A9 ^@ http://purl.uniprot.org/uniprot/A0A0A0MW31 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:ERF ^@ http://purl.uniprot.org/uniprot/A0A0A0MW28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9555:ZFYVE27 ^@ http://purl.uniprot.org/uniprot/A0A2I3LW89|||http://purl.uniprot.org/uniprot/A0A2I3N4E1 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Endosome membrane|||Membrane|||Recycling endosome membrane|||growth cone membrane http://togogenome.org/gene/9555:DUSP16 ^@ http://purl.uniprot.org/uniprot/A0A096NCT6 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9555:LIPH ^@ http://purl.uniprot.org/uniprot/A0A096MSG1|||http://purl.uniprot.org/uniprot/A0A2I3MHU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9555:IDH3G ^@ http://purl.uniprot.org/uniprot/A0A2I3MSB4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.|||Mitochondrion http://togogenome.org/gene/9555:LOC116268553 ^@ http://purl.uniprot.org/uniprot/A0A8I5MZN8 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/9555:DEFB132 ^@ http://purl.uniprot.org/uniprot/A0A096NV24 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9555:CD70 ^@ http://purl.uniprot.org/uniprot/A0A0A0MVV2 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9555:ASB12 ^@ http://purl.uniprot.org/uniprot/A0A096N9W0 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9555:GBF1 ^@ http://purl.uniprot.org/uniprot/A0A096P6E0|||http://purl.uniprot.org/uniprot/A0A8I5N5S9 ^@ Subcellular Location Annotation ^@ Golgi apparatus http://togogenome.org/gene/9555:TTR ^@ http://purl.uniprot.org/uniprot/A0A2I3MUT2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transthyretin family.|||Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4.|||Secreted|||Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. http://togogenome.org/gene/9555:HSPD1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MCE5 ^@ Similarity ^@ Belongs to the chaperonin (HSP60) family. http://togogenome.org/gene/9555:GCNT1 ^@ http://purl.uniprot.org/uniprot/A0A096N6B0 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9555:KCND1 ^@ http://purl.uniprot.org/uniprot/A0A096NPF3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||dendrite http://togogenome.org/gene/9555:METTL8 ^@ http://purl.uniprot.org/uniprot/A0A096NZH5 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/9555:EIF5 ^@ http://purl.uniprot.org/uniprot/A0A096NJY0 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/9555:REXO2 ^@ http://purl.uniprot.org/uniprot/A0A096N4L6 ^@ Similarity ^@ Belongs to the oligoribonuclease family. http://togogenome.org/gene/9555:ADSL ^@ http://purl.uniprot.org/uniprot/A0A096NK77 ^@ Function|||Similarity|||Subunit ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.|||Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site. http://togogenome.org/gene/9555:TADA3 ^@ http://purl.uniprot.org/uniprot/A0A096MUD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NGG1 family.|||Nucleus http://togogenome.org/gene/9555:GNAT2 ^@ http://purl.uniprot.org/uniprot/A0A096MX20 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9555:OR52E2 ^@ http://purl.uniprot.org/uniprot/A9L8W8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:HSPB2 ^@ http://purl.uniprot.org/uniprot/A0A096NCI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Nucleus http://togogenome.org/gene/9555:SERPINB2 ^@ http://purl.uniprot.org/uniprot/A9RA95 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9555:LOC101017878 ^@ http://purl.uniprot.org/uniprot/A0A096MWW5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat HIR1 family.|||Nucleus|||Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle. http://togogenome.org/gene/9555:UBE2B ^@ http://purl.uniprot.org/uniprot/A0A096MMR7 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9555:RPL21 ^@ http://purl.uniprot.org/uniprot/A0A096NA67 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/9555:RXFP1 ^@ http://purl.uniprot.org/uniprot/A0A096MM05|||http://purl.uniprot.org/uniprot/A0A2I3LCA8|||http://purl.uniprot.org/uniprot/A0A8I5NQD1 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:ORMDL3 ^@ http://purl.uniprot.org/uniprot/A0A8I5R0B5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/9555:EPCAM ^@ http://purl.uniprot.org/uniprot/A0A2I3M3Q6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPCAM family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lateral cell membrane|||May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.|||Membrane|||tight junction http://togogenome.org/gene/9555:VPS29 ^@ http://purl.uniprot.org/uniprot/A0A096NEB1|||http://purl.uniprot.org/uniprot/A0A2I3MNT8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.|||Belongs to the VPS29 family.|||Endosome membrane http://togogenome.org/gene/9555:NPR1 ^@ http://purl.uniprot.org/uniprot/A0A096NAX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane http://togogenome.org/gene/9555:MTG2 ^@ http://purl.uniprot.org/uniprot/A0A096NND0 ^@ Similarity ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. http://togogenome.org/gene/9555:DNMT3L ^@ http://purl.uniprot.org/uniprot/A0A096NIG6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:FPR3 ^@ http://purl.uniprot.org/uniprot/A0A8I5NK48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:TUBB2A ^@ http://purl.uniprot.org/uniprot/A9X1D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin family.|||cytoskeleton http://togogenome.org/gene/9555:GOSR1 ^@ http://purl.uniprot.org/uniprot/A0A096P3M6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GOSR1 family.|||Component of several multiprotein Golgi SNARE complexes.|||Golgi apparatus membrane|||Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.|||Membrane http://togogenome.org/gene/9555:OR51I2 ^@ http://purl.uniprot.org/uniprot/A9L8Y7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:MIEF2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NLX8 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9555:TUBGCP3 ^@ http://purl.uniprot.org/uniprot/A0A096MNC6|||http://purl.uniprot.org/uniprot/A9X167 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.|||centrosome http://togogenome.org/gene/9555:NSF ^@ http://purl.uniprot.org/uniprot/A0A2I3LW66 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. http://togogenome.org/gene/9555:TMEM115 ^@ http://purl.uniprot.org/uniprot/A0A096N5Q4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:TM6SF1 ^@ http://purl.uniprot.org/uniprot/A0A096NN04|||http://purl.uniprot.org/uniprot/A0A2I3MUU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TM6SF family.|||Membrane http://togogenome.org/gene/9555:RPL27 ^@ http://purl.uniprot.org/uniprot/A0A096P5W7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL27 family.|||Endoplasmic reticulum|||Rough endoplasmic reticulum http://togogenome.org/gene/9555:ASB2 ^@ http://purl.uniprot.org/uniprot/A0A096NJH5 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9555:HIBADH ^@ http://purl.uniprot.org/uniprot/A0A096N6A2 ^@ Similarity ^@ Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily. http://togogenome.org/gene/9555:LOC101018547 ^@ http://purl.uniprot.org/uniprot/A0A8I5NLF2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:CFAP126 ^@ http://purl.uniprot.org/uniprot/A0A096MP43 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the Flattop family. http://togogenome.org/gene/9555:PRDM5 ^@ http://purl.uniprot.org/uniprot/A0A2I3M8C3|||http://purl.uniprot.org/uniprot/A0A2I3MB98|||http://purl.uniprot.org/uniprot/A0A2I3N7X2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:RFFL ^@ http://purl.uniprot.org/uniprot/A0A2I3LJI6 ^@ Subcellular Location Annotation ^@ Cell membrane|||cytosol http://togogenome.org/gene/9555:CSTF1 ^@ http://purl.uniprot.org/uniprot/A0A096NNK1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:DNAJA1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LLW0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:SGCD ^@ http://purl.uniprot.org/uniprot/A0A8I5MZV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/9555:SMAD5 ^@ http://purl.uniprot.org/uniprot/A0A096MMR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:PCYT1B ^@ http://purl.uniprot.org/uniprot/A0A2I3NDN3 ^@ Function|||Similarity ^@ Belongs to the cytidylyltransferase family.|||Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. http://togogenome.org/gene/9555:SNX5 ^@ http://purl.uniprot.org/uniprot/A0A2I3MFB0 ^@ Function|||Similarity ^@ Belongs to the sorting nexin family.|||Involved in several stages of intracellular trafficking. http://togogenome.org/gene/9555:EIF2B2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NWP4 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/9555:CLIC2 ^@ http://purl.uniprot.org/uniprot/A0A096MLZ7 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/9555:TMEM39B ^@ http://purl.uniprot.org/uniprot/A0A096MSN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM39 family.|||Membrane http://togogenome.org/gene/9555:ERO1A ^@ http://purl.uniprot.org/uniprot/A0A096NV22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EROs family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9555:GTPBP10 ^@ http://purl.uniprot.org/uniprot/B0CM27 ^@ Similarity ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. http://togogenome.org/gene/9555:IL6 ^@ http://purl.uniprot.org/uniprot/C9EI26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-6 superfamily.|||Secreted http://togogenome.org/gene/9555:MED20 ^@ http://purl.uniprot.org/uniprot/A0A096NI43|||http://purl.uniprot.org/uniprot/A8MN31 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 20 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9555:RPS8 ^@ http://purl.uniprot.org/uniprot/A0A2I3MA04 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS8 family. http://togogenome.org/gene/9555:SNX32 ^@ http://purl.uniprot.org/uniprot/A0A096MMD1 ^@ Function|||Similarity ^@ Belongs to the sorting nexin family.|||Involved in several stages of intracellular trafficking. http://togogenome.org/gene/9555:RARA ^@ http://purl.uniprot.org/uniprot/A0A096P5G7|||http://purl.uniprot.org/uniprot/A0A2I3MRK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9555:TBX22 ^@ http://purl.uniprot.org/uniprot/A0A096MUJ2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9555:GNAI2 ^@ http://purl.uniprot.org/uniprot/A0A096MUH7 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9555:TAFA2 ^@ http://purl.uniprot.org/uniprot/A0A096MT42 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/9555:ALX3 ^@ http://purl.uniprot.org/uniprot/A0A096NH47 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:IAH1 ^@ http://purl.uniprot.org/uniprot/A0A096NIV5 ^@ Function|||Similarity ^@ Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.|||Probable lipase. http://togogenome.org/gene/9555:NTN4 ^@ http://purl.uniprot.org/uniprot/A0A8I5MVB2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:CDK5 ^@ http://purl.uniprot.org/uniprot/A0A096MSP7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:NME5 ^@ http://purl.uniprot.org/uniprot/A0A096MRH7 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9555:EPHB4 ^@ http://purl.uniprot.org/uniprot/A0A096N812 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:KPNA6 ^@ http://purl.uniprot.org/uniprot/A0A2I3LJG3 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9555:DAZAP2 ^@ http://purl.uniprot.org/uniprot/A0A096MUF9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus speckle|||nuclear body http://togogenome.org/gene/9555:IFI35 ^@ http://purl.uniprot.org/uniprot/A0A096P5W8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NMI family.|||Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/9555:CTLA4 ^@ http://purl.uniprot.org/uniprot/Q9BDN7 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.|||Membrane http://togogenome.org/gene/9555:OLFML2A ^@ http://purl.uniprot.org/uniprot/A0A096P0L8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:LOC101026205 ^@ http://purl.uniprot.org/uniprot/A0A096N467 ^@ Similarity ^@ Belongs to the CD99 family. http://togogenome.org/gene/9555:GGPS1 ^@ http://purl.uniprot.org/uniprot/A0A096NPM7 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9555:BRINP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MDE3 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/9555:TP53RK ^@ http://purl.uniprot.org/uniprot/A0A096NSE1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. BUD32 family. http://togogenome.org/gene/9555:DOK5 ^@ http://purl.uniprot.org/uniprot/A0A096NNK9 ^@ Similarity ^@ Belongs to the DOK family. Type B subfamily. http://togogenome.org/gene/9555:KCNA1 ^@ http://purl.uniprot.org/uniprot/A0A096N578 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9555:TFEC ^@ http://purl.uniprot.org/uniprot/A0A096NU84|||http://purl.uniprot.org/uniprot/A0A096NU85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/9555:RELL2 ^@ http://purl.uniprot.org/uniprot/A0A096NRL1 ^@ Similarity ^@ Belongs to the RELT family. http://togogenome.org/gene/9555:BARHL1 ^@ http://purl.uniprot.org/uniprot/A0A096P0E1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:CA7 ^@ http://purl.uniprot.org/uniprot/A0A096NJ93 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9555:OLFR604 ^@ http://purl.uniprot.org/uniprot/A9L8W9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:LOC101026920 ^@ http://purl.uniprot.org/uniprot/A0A8I5QZY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:TRIM58 ^@ http://purl.uniprot.org/uniprot/A0A8I5N0Q7 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9555:MCMBP ^@ http://purl.uniprot.org/uniprot/A0A096NTZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCMBP family.|||Nucleus http://togogenome.org/gene/9555:LIG3 ^@ http://purl.uniprot.org/uniprot/A0A096P3V0|||http://purl.uniprot.org/uniprot/A0A2I3MRZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent DNA ligase family.|||Nucleus http://togogenome.org/gene/9555:ABT1 ^@ http://purl.uniprot.org/uniprot/A9X182 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESF2/ABP1 family.|||nucleolus http://togogenome.org/gene/9555:SPP1 ^@ http://purl.uniprot.org/uniprot/A0A096N0A2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the osteopontin family.|||Secreted http://togogenome.org/gene/9555:CCKBR ^@ http://purl.uniprot.org/uniprot/A0A8I5NNE2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9555:MGAT4D ^@ http://purl.uniprot.org/uniprot/A0A096MUH6|||http://purl.uniprot.org/uniprot/A0A2I3MVZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 54 family.|||Golgi apparatus membrane http://togogenome.org/gene/9555:NEURL2 ^@ http://purl.uniprot.org/uniprot/A0A096NX28 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:PSMB1 ^@ http://purl.uniprot.org/uniprot/A0A096NVZ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:MCOLN2 ^@ http://purl.uniprot.org/uniprot/A0A096MXN5 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9555:DYRK3 ^@ http://purl.uniprot.org/uniprot/A0A096N2U1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. http://togogenome.org/gene/9555:DDR2 ^@ http://purl.uniprot.org/uniprot/A0A096MUC1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:UGT1A5A ^@ http://purl.uniprot.org/uniprot/Q20CL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9555:CTSB ^@ http://purl.uniprot.org/uniprot/A0A096NCA1 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9555:ABL2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LLL1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9555:LOC101000949 ^@ http://purl.uniprot.org/uniprot/A0A0A0MWG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM187 family.|||Membrane http://togogenome.org/gene/9555:CBL ^@ http://purl.uniprot.org/uniprot/A0A096MW73 ^@ Domain|||Function ^@ E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.|||The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain. http://togogenome.org/gene/9555:HBB ^@ http://purl.uniprot.org/uniprot/Q9TSP1 ^@ Function|||Similarity|||Subunit|||Tissue Specificity ^@ Belongs to the globin family.|||Heterotetramer of two alpha chains and two beta chains.|||Involved in oxygen transport from the lung to the various peripheral tissues.|||Red blood cells. http://togogenome.org/gene/9555:RNF145 ^@ http://purl.uniprot.org/uniprot/A0A2I3MD96 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:E2F8 ^@ http://purl.uniprot.org/uniprot/A0A096MSF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9555:RAB18 ^@ http://purl.uniprot.org/uniprot/A0A8I5N7V2 ^@ Subcellular Location Annotation ^@ Apical cell membrane|||Cell membrane|||Lipid droplet http://togogenome.org/gene/9555:GREM1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NKF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Secreted http://togogenome.org/gene/9555:NAMPT ^@ http://purl.uniprot.org/uniprot/A0A2I3MY75 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAPRTase family.|||Cytoplasm|||Homodimer.|||Nucleus|||Secreted http://togogenome.org/gene/9555:LYRM2 ^@ http://purl.uniprot.org/uniprot/A0A096MWU3 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9555:PIH1D3 ^@ http://purl.uniprot.org/uniprot/A0A096MQV1 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/9555:HSP90AB1 ^@ http://purl.uniprot.org/uniprot/A0A096NIL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 90 family.|||Melanosome http://togogenome.org/gene/9555:PDE7B ^@ http://purl.uniprot.org/uniprot/A0A096NQX1|||http://purl.uniprot.org/uniprot/A0A2I3MPB9 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9555:KRT18 ^@ http://purl.uniprot.org/uniprot/A0A096MRQ2 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9555:CPA4 ^@ http://purl.uniprot.org/uniprot/A0A096NGG9 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9555:TOE1 ^@ http://purl.uniprot.org/uniprot/A0A096NQK7 ^@ Similarity ^@ Belongs to the CAF1 family. http://togogenome.org/gene/9555:RTCB ^@ http://purl.uniprot.org/uniprot/A9CB42 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Catalytic component of the tRNA-splicing ligase complex.|||Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.|||Cytoplasm|||Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.|||Nucleus http://togogenome.org/gene/9555:OTOP3 ^@ http://purl.uniprot.org/uniprot/A0A096NSS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the otopetrin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:MYB ^@ http://purl.uniprot.org/uniprot/A0A096NDT6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:ALG11 ^@ http://purl.uniprot.org/uniprot/A0A096MPG7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.|||Endoplasmic reticulum membrane|||Required for N-linked oligosaccharide assembly. http://togogenome.org/gene/9555:ATP1A4 ^@ http://purl.uniprot.org/uniprot/A0A096NZ64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:CER1 ^@ http://purl.uniprot.org/uniprot/A0A096P1I6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9555:LOC101023546 ^@ http://purl.uniprot.org/uniprot/A0A096NV15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9555:AIG1 ^@ http://purl.uniprot.org/uniprot/A0A2I3M0I9|||http://purl.uniprot.org/uniprot/A0A2I3MH63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIG1 family.|||Membrane http://togogenome.org/gene/9555:PLA2G3 ^@ http://purl.uniprot.org/uniprot/A0A096NJM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Secreted http://togogenome.org/gene/9555:N4BP3 ^@ http://purl.uniprot.org/uniprot/A0A096NAF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the N4BP3 family.|||Vesicle|||dendrite http://togogenome.org/gene/9555:MINDY1 ^@ http://purl.uniprot.org/uniprot/A0A096NP94 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM63 subfamily.|||Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover. http://togogenome.org/gene/9555:BOLA1 ^@ http://purl.uniprot.org/uniprot/A0A096NDP8 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/9555:OAT ^@ http://purl.uniprot.org/uniprot/A0A096NU53 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9555:CCNA1 ^@ http://purl.uniprot.org/uniprot/A0A096NEN4 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin AB subfamily. http://togogenome.org/gene/9555:CLIC3 ^@ http://purl.uniprot.org/uniprot/A0A096NRQ1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/9555:NUDT5 ^@ http://purl.uniprot.org/uniprot/A0A096P3F4|||http://purl.uniprot.org/uniprot/A0A2I3NE09 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/9555:GRIA3 ^@ http://purl.uniprot.org/uniprot/A0A2I3N2F7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/9555:LOC101017841 ^@ http://purl.uniprot.org/uniprot/A0A2I3M0V4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCRQ/QCR8 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:RBM5 ^@ http://purl.uniprot.org/uniprot/A0A096MUY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RBM5/RBM10 family.|||Nucleus http://togogenome.org/gene/9555:LRTOMT ^@ http://purl.uniprot.org/uniprot/A0A2I3MDB0|||http://purl.uniprot.org/uniprot/B6CZ52 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. http://togogenome.org/gene/9555:POLH ^@ http://purl.uniprot.org/uniprot/A0A096NIH2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:PRKACA ^@ http://purl.uniprot.org/uniprot/A0A2I3N1F5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/9555:MAP1LC3B ^@ http://purl.uniprot.org/uniprot/A0A096NS02 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9555:PTGER4 ^@ http://purl.uniprot.org/uniprot/A0A096N4Q5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with FEM1A.|||Membrane|||Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. http://togogenome.org/gene/9555:LDAH ^@ http://purl.uniprot.org/uniprot/A0A096N270 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. LDAH family.|||Lipid droplet http://togogenome.org/gene/9555:SPNS2 ^@ http://purl.uniprot.org/uniprot/A0A096P2F7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.|||Membrane http://togogenome.org/gene/9555:SLC25A12 ^@ http://purl.uniprot.org/uniprot/A0A2I3MLS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:CEP70 ^@ http://purl.uniprot.org/uniprot/A0A096MWL1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.|||Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.|||centrosome http://togogenome.org/gene/9555:SDR16C5 ^@ http://purl.uniprot.org/uniprot/A0A096N215 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9555:TMEM59 ^@ http://purl.uniprot.org/uniprot/A0A096MP87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM59 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9555:KLHL21 ^@ http://purl.uniprot.org/uniprot/A0A096NDF5 ^@ Subcellular Location Annotation ^@ spindle http://togogenome.org/gene/9555:ACAT1 ^@ http://purl.uniprot.org/uniprot/A0A096MZB0 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/9555:CDC42EP1 ^@ http://purl.uniprot.org/uniprot/A0A096NJW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/9555:CDH2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MKR0 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:LOC101005729 ^@ http://purl.uniprot.org/uniprot/A0A2I3MQ20 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the p22phox family.|||Cell membrane|||Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).|||Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.|||Membrane http://togogenome.org/gene/9555:CERS2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NVP7 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9555:MBLAC1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NKR5 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. http://togogenome.org/gene/9555:COX3 ^@ http://purl.uniprot.org/uniprot/K9MUG4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane http://togogenome.org/gene/9555:ATP6V0D1 ^@ http://purl.uniprot.org/uniprot/A0A096NH68 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9555:CTNNBL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MFL4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:RPS13 ^@ http://purl.uniprot.org/uniprot/A0A2I3MNN3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/9555:MED13 ^@ http://purl.uniprot.org/uniprot/A0A096P4Y1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 13 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9555:CNIH4 ^@ http://purl.uniprot.org/uniprot/A0A2I3LVH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/9555:MYH11 ^@ http://purl.uniprot.org/uniprot/A0A2I3LFK6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9555:EPC2 ^@ http://purl.uniprot.org/uniprot/A0A096NSM8|||http://purl.uniprot.org/uniprot/A0A2I3N8H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enhancer of polycomb family.|||Nucleus http://togogenome.org/gene/9555:GSG1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MP76|||http://purl.uniprot.org/uniprot/A0A2I3N4J3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSG1 family.|||Membrane http://togogenome.org/gene/9555:TSPAN17 ^@ http://purl.uniprot.org/uniprot/A0A8I5R251 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9555:CASP6 ^@ http://purl.uniprot.org/uniprot/A0A096N6Y2 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9555:NR2F1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LQB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9555:PDGFRA ^@ http://purl.uniprot.org/uniprot/A0A2I3MN46 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.|||Membrane|||Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.|||Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. http://togogenome.org/gene/9555:CHCHD4 ^@ http://purl.uniprot.org/uniprot/A0A2I3M4D5|||http://purl.uniprot.org/uniprot/A0A8I5NQV2 ^@ Subcellular Location Annotation ^@ Mitochondrion intermembrane space http://togogenome.org/gene/9555:EIF5A2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MV74 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Endoplasmic reticulum membrane|||Membrane|||Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.|||eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group. http://togogenome.org/gene/9555:BAZ2A ^@ http://purl.uniprot.org/uniprot/A0A2I3MGP6 ^@ Similarity ^@ Belongs to the WAL family. http://togogenome.org/gene/9555:MC1R ^@ http://purl.uniprot.org/uniprot/Q864J3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production. Interacts with OPN3; the interaction results in a decrease in MC1R-mediated cAMP signaling and ultimately a decrease in melanin production in melanocytes.|||Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes. http://togogenome.org/gene/9555:ATP1B3 ^@ http://purl.uniprot.org/uniprot/A0A096N415|||http://purl.uniprot.org/uniprot/A0A2I3LCU2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9555:TNFAIP3 ^@ http://purl.uniprot.org/uniprot/A0A096NQC6|||http://purl.uniprot.org/uniprot/A0A8I5MZ59 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9555:ADIPOR1 ^@ http://purl.uniprot.org/uniprot/A0A096N3Q0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9555:SURF4 ^@ http://purl.uniprot.org/uniprot/A0A096MSW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SURF4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:ISY1 ^@ http://purl.uniprot.org/uniprot/A0A096MPI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ISY1 family.|||Nucleus http://togogenome.org/gene/9555:FAAH ^@ http://purl.uniprot.org/uniprot/A0A096NXR0 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/9555:EHD3 ^@ http://purl.uniprot.org/uniprot/A0A096MQ79 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/9555:CRKL ^@ http://purl.uniprot.org/uniprot/A0A096NS79 ^@ Similarity ^@ Belongs to the CRK family. http://togogenome.org/gene/9555:BAMBI ^@ http://purl.uniprot.org/uniprot/A0A8I5P3K4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BAMBI family.|||Membrane|||Negatively regulates TGF-beta signaling. http://togogenome.org/gene/9555:LOC101019367 ^@ http://purl.uniprot.org/uniprot/A0A8I5NKI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:CNIH3 ^@ http://purl.uniprot.org/uniprot/A0A096N3H4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/9555:MON1A ^@ http://purl.uniprot.org/uniprot/A0A096MM06|||http://purl.uniprot.org/uniprot/A0A2I3LPT3 ^@ Function|||Similarity ^@ Belongs to the MON1/SAND family.|||Plays an important role in membrane trafficking through the secretory apparatus. http://togogenome.org/gene/9555:SYT17 ^@ http://purl.uniprot.org/uniprot/A0A096MWV5|||http://purl.uniprot.org/uniprot/A0A096NQJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Membrane http://togogenome.org/gene/9555:CSGALNACT1 ^@ http://purl.uniprot.org/uniprot/A0A096NXK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9555:HNRNPA3 ^@ http://purl.uniprot.org/uniprot/A0A096NPT5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:UBE2K ^@ http://purl.uniprot.org/uniprot/A0A096N3L7 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9555:NPY1R ^@ http://purl.uniprot.org/uniprot/A0A8I5R9R5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9555:CD3E ^@ http://purl.uniprot.org/uniprot/A0A2I3NE27 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:DAO ^@ http://purl.uniprot.org/uniprot/A0A096NQF0|||http://purl.uniprot.org/uniprot/A0A2I3M6S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAMOX/DASOX family.|||Peroxisome http://togogenome.org/gene/9555:CNR2 ^@ http://purl.uniprot.org/uniprot/A0A096NEF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:MDK ^@ http://purl.uniprot.org/uniprot/A0A096MPE6 ^@ Similarity ^@ Belongs to the pleiotrophin family. http://togogenome.org/gene/9555:ZNRD1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NGH0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.|||nucleolus http://togogenome.org/gene/9555:DNAJC18 ^@ http://purl.uniprot.org/uniprot/A0A096N9Y2 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:MYOZ3 ^@ http://purl.uniprot.org/uniprot/A0A096MSX7 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/9555:LOC108584558 ^@ http://purl.uniprot.org/uniprot/A0A8I5N8F7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/9555:FRRS1 ^@ http://purl.uniprot.org/uniprot/A0A096N3C9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FRRS1 family.|||Membrane http://togogenome.org/gene/9555:GIPC1 ^@ http://purl.uniprot.org/uniprot/A0A0A0MVP6 ^@ Similarity ^@ Belongs to the GIPC family. http://togogenome.org/gene/9555:NPL ^@ http://purl.uniprot.org/uniprot/A0A096NG31 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family. NanA subfamily.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/9555:ACTN1 ^@ http://purl.uniprot.org/uniprot/A0A096NVR2 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/9555:PDIA6 ^@ http://purl.uniprot.org/uniprot/A0A2I3LEN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen|||Melanosome http://togogenome.org/gene/9555:LOC103887933 ^@ http://purl.uniprot.org/uniprot/A0A096NNJ8 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9555:DNM2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LFK3|||http://purl.uniprot.org/uniprot/A0A2I3MM57|||http://purl.uniprot.org/uniprot/A0A2I3MQ44 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/9555:GJA5 ^@ http://purl.uniprot.org/uniprot/A0A096NXH7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9555:LPL ^@ http://purl.uniprot.org/uniprot/P49060 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Cell membrane|||Highest levels in the spinal cord.|||Homodimer. Interacts with GPIHBP1 with 1:1 stoichiometry (By similarity). Interacts with APOC2; the interaction activates LPL activity in the presence of lipids (By similarity). Interaction with heparan sulfate proteoglycans is required to protect LPL against loss of activity. Associates with lipoprotein particles in blood plasma. Interacts with LMF1 and SEL1L; interaction with SEL1L is required to prevent aggregation of newly synthesized LPL in the endoplasmic reticulum (ER), and for normal export of LPL from the ER to the extracellular space (By similarity). Interacts with SORL1; SORL1 acts as a sorting receptor, promoting LPL localization to endosomes and later to lysosomes, leading to degradation of newly synthesized LPL (By similarity).|||Key enzyme in triglyceride metabolism (By similarity). Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage (By similarity). Although it has both phospholipase and triglyceride lipase activities it is primarily a triglyceride lipase with low but detectable phospholipase activity (By similarity). Mediates margination of triglyceride-rich lipoprotein particles in capillaries (By similarity). Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans (By similarity).|||Secreted|||The apolipoprotein APOC2 acts as a coactivator of LPL activity (By similarity). Ca(2+) binding promotes protein stability and formation of the active homodimer. Interaction with GPIHBP1 protects LPL against inactivation by ANGPTL4 (By similarity).|||Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.|||extracellular matrix http://togogenome.org/gene/9555:RGMB ^@ http://purl.uniprot.org/uniprot/A0A2I3M9J0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the repulsive guidance molecule (RGM) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:TCAF2 ^@ http://purl.uniprot.org/uniprot/A0A096N3X2 ^@ Similarity ^@ Belongs to the TCAF family. http://togogenome.org/gene/9555:SEMA6C ^@ http://purl.uniprot.org/uniprot/A9X191 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:SSR1 ^@ http://purl.uniprot.org/uniprot/A0A8I5MZT4|||http://purl.uniprot.org/uniprot/A0A8I5NGL8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-alpha family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.|||Membrane|||Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. http://togogenome.org/gene/9555:HSPA4 ^@ http://purl.uniprot.org/uniprot/A0A2I3MR44 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 70 family.|||Cytoplasm|||Interacts with TJP1/ZO-1. http://togogenome.org/gene/9555:TMEM134 ^@ http://purl.uniprot.org/uniprot/A0A096MM70|||http://purl.uniprot.org/uniprot/A0A2I3N6Z5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM134/TMEM230 family.|||Membrane http://togogenome.org/gene/9555:NDUFB10 ^@ http://purl.uniprot.org/uniprot/A0A096NKY8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.|||Belongs to the complex I NDUFB10 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:KMT2A ^@ http://purl.uniprot.org/uniprot/A0A096N911 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.|||Nucleus http://togogenome.org/gene/9555:RPL3L ^@ http://purl.uniprot.org/uniprot/A0A096NKY6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/9555:GRIK1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MFK0|||http://purl.uniprot.org/uniprot/A0A2I3MJ65|||http://purl.uniprot.org/uniprot/A0A2I3MXB9|||http://purl.uniprot.org/uniprot/A0A2I3N5T5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/9555:TMEM35A ^@ http://purl.uniprot.org/uniprot/A0A8I5R6N6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Membrane http://togogenome.org/gene/9555:ADRA2C ^@ http://purl.uniprot.org/uniprot/A0A096NA11 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.|||Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:AQP3 ^@ http://purl.uniprot.org/uniprot/A0A8I5R1L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:LOC101012229 ^@ http://purl.uniprot.org/uniprot/A0A096NLJ7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:KDM4C ^@ http://purl.uniprot.org/uniprot/A0A8I5NI57|||http://purl.uniprot.org/uniprot/A0A8I5R8Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JHDM3 histone demethylase family.|||Nucleus http://togogenome.org/gene/9555:DNTT ^@ http://purl.uniprot.org/uniprot/A0A096P5U2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||Nucleus|||Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. http://togogenome.org/gene/9555:CORO6 ^@ http://purl.uniprot.org/uniprot/A0A2I3MZU8 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/9555:SNRNP200 ^@ http://purl.uniprot.org/uniprot/A0A096NDJ1 ^@ Similarity ^@ Belongs to the helicase family. SKI2 subfamily. http://togogenome.org/gene/9555:BTDA ^@ http://purl.uniprot.org/uniprot/B6ULW4 ^@ Function|||PTM|||Similarity|||Subunit ^@ BTD-1 is a cyclic heterodimer composed of subunits A and B; disulfide-linked. BTD-3 is a cyclic homodimer composed of two subunits A; disulfide-linked. BTD-4 is a cyclic heterodimer composed of subunits A and C; disulfide-linked. BTD-7 is a cyclic heterodimer composed of subunits A and D; disulfide-linked.|||BTD-1, BTD-3, BTD-4 and BTD-7 have antimicrobial activity against the Gram-negative bacterium E.coli ML35, the Gram-positive bacterium S.aureus 502a, and the fungus C.albicans 16820. BTD-3 is more effective against E.coli than BTD-1, BTD-4 and BTD-7.|||Belongs to the alpha-defensin family. Theta subfamily.|||Forms a cyclic peptide with subunit B (BTD-1), subunit A (BTD-3), subunit C (BTD-4), or subunit D (BTD-7). An additional intersubunit disulfide bond is formed. http://togogenome.org/gene/9555:ASIC4 ^@ http://purl.uniprot.org/uniprot/B0CM53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.|||Membrane http://togogenome.org/gene/9555:C8A ^@ http://purl.uniprot.org/uniprot/A0A096NA36 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Secreted http://togogenome.org/gene/9555:LOC101022294 ^@ http://purl.uniprot.org/uniprot/A0A096NFZ7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:FCF1 ^@ http://purl.uniprot.org/uniprot/A0A096NQ99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP23/FCF1 family. FCF1 subfamily.|||nucleolus http://togogenome.org/gene/9555:TWSG1 ^@ http://purl.uniprot.org/uniprot/A0A096N498 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the twisted gastrulation protein family.|||Secreted http://togogenome.org/gene/9555:LOC101004600 ^@ http://purl.uniprot.org/uniprot/A0A2I3MTM8 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9555:GALT ^@ http://purl.uniprot.org/uniprot/A0A2I3N548 ^@ Similarity ^@ Belongs to the galactose-1-phosphate uridylyltransferase type 1 family. http://togogenome.org/gene/9555:LAGE3 ^@ http://purl.uniprot.org/uniprot/A0A096N606 ^@ Similarity ^@ Belongs to the CTAG/PCC1 family. http://togogenome.org/gene/9555:ATP13A1 ^@ http://purl.uniprot.org/uniprot/A0A0A0MXC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.|||Membrane http://togogenome.org/gene/9555:BLCAP ^@ http://purl.uniprot.org/uniprot/A0A096MQ82 ^@ Function|||Similarity ^@ Belongs to the BLCAP family.|||May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B. http://togogenome.org/gene/9555:MED29 ^@ http://purl.uniprot.org/uniprot/A0A0A0MV48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 29 family.|||Nucleus http://togogenome.org/gene/9555:HARS1 ^@ http://purl.uniprot.org/uniprot/A0A096ND58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/9555:CCNL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3NH80 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9555:C4BPB ^@ http://purl.uniprot.org/uniprot/A0A2I3MB60 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:RNASEH2A ^@ http://purl.uniprot.org/uniprot/A0A2I3N0D3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the RNase HII family. Eukaryotic subfamily.|||Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/9555:CYFIP1 ^@ http://purl.uniprot.org/uniprot/A0A096NT16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYFIP family.|||synaptosome http://togogenome.org/gene/9555:LOC101021604 ^@ http://purl.uniprot.org/uniprot/A0A096N3A5 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Component of the 40S small ribosomal subunit. http://togogenome.org/gene/9555:PWWP3B ^@ http://purl.uniprot.org/uniprot/A0A8I5NEJ6 ^@ Similarity ^@ Belongs to the PWWP3A family. http://togogenome.org/gene/9555:MYRF ^@ http://purl.uniprot.org/uniprot/A0A2I3NA81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRF family.|||Membrane http://togogenome.org/gene/9555:CDK1 ^@ http://purl.uniprot.org/uniprot/A0A096P561 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:DTX3 ^@ http://purl.uniprot.org/uniprot/A0A096MZI1|||http://purl.uniprot.org/uniprot/A0A096N3S5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Deltex family.|||Cytoplasm http://togogenome.org/gene/9555:SFMBT1 ^@ http://purl.uniprot.org/uniprot/A0A096N7P6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:PEX19 ^@ http://purl.uniprot.org/uniprot/A0A096MYZ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxin-19 family.|||Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.|||Membrane|||Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.|||Peroxisome membrane http://togogenome.org/gene/9555:HSPB3 ^@ http://purl.uniprot.org/uniprot/A0A096NCG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Nucleus http://togogenome.org/gene/9555:CFDP1 ^@ http://purl.uniprot.org/uniprot/A0A096NQ86 ^@ Function|||Subcellular Location Annotation ^@ May play a role during embryogenesis.|||kinetochore http://togogenome.org/gene/9555:SPDEF ^@ http://purl.uniprot.org/uniprot/A0A096NHL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9555:ST3GAL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MRS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9555:CCDC124 ^@ http://purl.uniprot.org/uniprot/A0A0A0MWQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC124 family.|||Midbody http://togogenome.org/gene/9555:PPAT ^@ http://purl.uniprot.org/uniprot/A0A096NDS3 ^@ Cofactor|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/9555:FLAD1 ^@ http://purl.uniprot.org/uniprot/A0A096NWG6 ^@ Function|||Similarity ^@ Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.|||In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.|||In the N-terminal section; belongs to the MoaB/Mog family. http://togogenome.org/gene/9555:ATG4C ^@ http://purl.uniprot.org/uniprot/A0A096MWY4|||http://purl.uniprot.org/uniprot/A0A8I5N2D3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/9555:HARS2 ^@ http://purl.uniprot.org/uniprot/A0A096NZ15|||http://purl.uniprot.org/uniprot/A0A2I3M6V7 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9555:SPDL1 ^@ http://purl.uniprot.org/uniprot/A0A096N5S7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Spindly family.|||Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect.|||Nucleus|||Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.|||centrosome|||kinetochore|||spindle pole http://togogenome.org/gene/9555:LOC101026362 ^@ http://purl.uniprot.org/uniprot/A0A096NA40 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/9555:SLC10A2 ^@ http://purl.uniprot.org/uniprot/A0A8I5MYR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/9555:LYRM7 ^@ http://purl.uniprot.org/uniprot/A0A096N4E8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.|||Belongs to the complex I LYR family.|||Interacts with UQCRFS1.|||Mitochondrion matrix http://togogenome.org/gene/9555:HOXD3 ^@ http://purl.uniprot.org/uniprot/A0A096N3X1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9555:TMEM161B ^@ http://purl.uniprot.org/uniprot/A0A8I5MVQ4|||http://purl.uniprot.org/uniprot/A0A8I5N515 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM161 family.|||Membrane http://togogenome.org/gene/9555:PPM1L ^@ http://purl.uniprot.org/uniprot/A0A2I3M9Z5 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9555:OTOP1 ^@ http://purl.uniprot.org/uniprot/A0A096NZF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the otopetrin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:AGPAT4 ^@ http://purl.uniprot.org/uniprot/A0A096N5M9 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9555:LOC101001071 ^@ http://purl.uniprot.org/uniprot/A0A096MR93 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/9555:SERINC4 ^@ http://purl.uniprot.org/uniprot/A9X1C3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9555:PPIF ^@ http://purl.uniprot.org/uniprot/A0A096P4H0 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9555:ATP6V1D ^@ http://purl.uniprot.org/uniprot/A0A096NVN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase D subunit family.|||cilium|||clathrin-coated vesicle membrane http://togogenome.org/gene/9555:IMMP2L ^@ http://purl.uniprot.org/uniprot/A0A2I3NHU2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26 family. IMP2 subfamily.|||Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.|||Heterodimer of 2 subunits, IMMPL1 and IMMPL2.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:ATP5MD ^@ http://purl.uniprot.org/uniprot/A0A096MSB1 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion membrane http://togogenome.org/gene/9555:NBN ^@ http://purl.uniprot.org/uniprot/E5FGM3 ^@ Subcellular Location Annotation ^@ Nucleus|||telomere http://togogenome.org/gene/9555:TMEM106A ^@ http://purl.uniprot.org/uniprot/A0A096P5X5 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/9555:APEX1 ^@ http://purl.uniprot.org/uniprot/A0A096NNL1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Cytoplasm|||Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.|||Mitochondrion|||Nucleus|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/9555:ELK3 ^@ http://purl.uniprot.org/uniprot/A0A8I5N934 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9555:GPAT4 ^@ http://purl.uniprot.org/uniprot/A0A096N0N6 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9555:DDX49 ^@ http://purl.uniprot.org/uniprot/A0A0A0MVX5 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9555:HPRT1 ^@ http://purl.uniprot.org/uniprot/A0A2I3N9E6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/9555:PGM2L1 ^@ http://purl.uniprot.org/uniprot/A0A096MUB3 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/9555:CDIPT ^@ http://purl.uniprot.org/uniprot/A0A096NMJ6|||http://purl.uniprot.org/uniprot/A0A2I3MUG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/9555:ATP8 ^@ http://purl.uniprot.org/uniprot/K9MUQ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase protein 8 family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion membrane http://togogenome.org/gene/9555:LOC101022429 ^@ http://purl.uniprot.org/uniprot/A0A096N7S1 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS25 family.|||Component of the small ribosomal subunit. http://togogenome.org/gene/9555:TRMT11 ^@ http://purl.uniprot.org/uniprot/A0A096MS70|||http://purl.uniprot.org/uniprot/A0A2I3LX05 ^@ Function|||Subunit ^@ Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.|||Interacts with TRMT112. http://togogenome.org/gene/9555:SLC13A3 ^@ http://purl.uniprot.org/uniprot/A0A2I3LXV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/9555:TRAF5 ^@ http://purl.uniprot.org/uniprot/A0A8I5NX21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/9555:SLC10A4 ^@ http://purl.uniprot.org/uniprot/A0A096N3W9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/9555:GNG8 ^@ http://purl.uniprot.org/uniprot/A0A2I3MIM6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9555:GFM2 ^@ http://purl.uniprot.org/uniprot/A0A8I5R7G4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.|||Mitochondrion http://togogenome.org/gene/9555:C10H2orf88 ^@ http://purl.uniprot.org/uniprot/A0A096ML70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small membrane AKAP family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:CUTA ^@ http://purl.uniprot.org/uniprot/A0A096NHI8 ^@ Similarity|||Subunit ^@ Belongs to the CutA family.|||Homotrimer. http://togogenome.org/gene/9555:LOXL4 ^@ http://purl.uniprot.org/uniprot/A0A096P627 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/9555:SSTR2 ^@ http://purl.uniprot.org/uniprot/A0A096NU50 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).|||Membrane|||Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization. http://togogenome.org/gene/9555:EN1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LZS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Engrailed homeobox family.|||Nucleus http://togogenome.org/gene/9555:LCORL ^@ http://purl.uniprot.org/uniprot/A0A8I5NMP6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:TLR3 ^@ http://purl.uniprot.org/uniprot/A0A096MRL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9555:CA12 ^@ http://purl.uniprot.org/uniprot/A0A096NMA4 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9555:LIF ^@ http://purl.uniprot.org/uniprot/A0A8I5NIH2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LIF/OSM family.|||LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.|||Secreted http://togogenome.org/gene/9555:RSAD1 ^@ http://purl.uniprot.org/uniprot/A0A096P4J0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.|||May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen-III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Mitochondrion http://togogenome.org/gene/9555:PDIK1L ^@ http://purl.uniprot.org/uniprot/A0A8I5NUW8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:USP33 ^@ http://purl.uniprot.org/uniprot/A0A096NE89 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family. USP20/USP33 subfamily.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||centrosome|||perinuclear region http://togogenome.org/gene/9555:ROR1 ^@ http://purl.uniprot.org/uniprot/A0A096N7B7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:LOC101025966 ^@ http://purl.uniprot.org/uniprot/A0A8I5NMF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9555:PUS7L ^@ http://purl.uniprot.org/uniprot/A0A096N4R8 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruD family. http://togogenome.org/gene/9555:NKAIN2 ^@ http://purl.uniprot.org/uniprot/A0A096NCE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NKAIN family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:MBTPS1 ^@ http://purl.uniprot.org/uniprot/A0A096NPH3 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9555:HRH3 ^@ http://purl.uniprot.org/uniprot/A0A8I5R123 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9555:PFKM ^@ http://purl.uniprot.org/uniprot/A0A096N5N7|||http://purl.uniprot.org/uniprot/A0A8I5NCT7 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homo- and heterotetramers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:HDAC8 ^@ http://purl.uniprot.org/uniprot/A0A2I3M3F1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones.|||Nucleus http://togogenome.org/gene/9555:MED10 ^@ http://purl.uniprot.org/uniprot/A0A096MNU8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 10 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9555:ARID5B ^@ http://purl.uniprot.org/uniprot/A0A2I3LUT5 ^@ Similarity ^@ Belongs to the ARID5B family. http://togogenome.org/gene/9555:RNFT2 ^@ http://purl.uniprot.org/uniprot/A0A096NC27 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:LOC101005217 ^@ http://purl.uniprot.org/uniprot/A0A8I5R6I5 ^@ Similarity ^@ Belongs to the PRR23 family. http://togogenome.org/gene/9555:HUWE1 ^@ http://purl.uniprot.org/uniprot/A0A096N834 ^@ Similarity ^@ Belongs to the UPL family. TOM1/PTR1 subfamily. http://togogenome.org/gene/9555:LOC103879121 ^@ http://purl.uniprot.org/uniprot/A0A096NBI0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. http://togogenome.org/gene/9555:ADRA2A ^@ http://purl.uniprot.org/uniprot/A0A8I5R9I5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:STOML1 ^@ http://purl.uniprot.org/uniprot/A0A8I5MUZ1 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/9555:BCAP29 ^@ http://purl.uniprot.org/uniprot/A0A2I3MV91 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCAP29/BCAP31 family.|||Endoplasmic reticulum membrane|||Membrane|||Plays a role in the export of secreted proteins in the ER. http://togogenome.org/gene/9555:RPS14 ^@ http://purl.uniprot.org/uniprot/A0A2I3LIT8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/9555:TMEM186 ^@ http://purl.uniprot.org/uniprot/A0A096NLL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM186 family.|||Membrane http://togogenome.org/gene/9555:LOC101005744 ^@ http://purl.uniprot.org/uniprot/A0A096NJK5 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9555:GGCX ^@ http://purl.uniprot.org/uniprot/A0A096NZU5 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:YWHAH ^@ http://purl.uniprot.org/uniprot/A9CB38 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9555:TSPO ^@ http://purl.uniprot.org/uniprot/A0A096NKG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TspO/BZRP family.|||Membrane http://togogenome.org/gene/9555:BMP4 ^@ http://purl.uniprot.org/uniprot/B0CM38 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9555:PTS ^@ http://purl.uniprot.org/uniprot/A0A096NC15 ^@ Function|||Similarity ^@ Belongs to the PTPS family.|||Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. http://togogenome.org/gene/9555:AK6 ^@ http://purl.uniprot.org/uniprot/A0A8I5N3Z7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.|||Cajal body|||Monomer and homodimer. Interacts with COIL (via C-terminus).|||nucleoplasm http://togogenome.org/gene/9555:PHYHIPL ^@ http://purl.uniprot.org/uniprot/A0A096P572 ^@ Similarity ^@ Belongs to the PHYHIP family. http://togogenome.org/gene/9555:FAM53C ^@ http://purl.uniprot.org/uniprot/A0A096N466 ^@ Similarity ^@ Belongs to the FAM53 family. http://togogenome.org/gene/9555:EXOSC3 ^@ http://purl.uniprot.org/uniprot/A0A096P146 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP40 family.|||Cytoplasm|||nucleolus http://togogenome.org/gene/9555:RPTOR ^@ http://purl.uniprot.org/uniprot/A0A096NTC6 ^@ Similarity ^@ Belongs to the WD repeat RAPTOR family. http://togogenome.org/gene/9555:CPM ^@ http://purl.uniprot.org/uniprot/A0A096NEM8 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9555:TEX28 ^@ http://purl.uniprot.org/uniprot/A9CB55 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/9555:YDJC ^@ http://purl.uniprot.org/uniprot/A0A096NS93 ^@ Function|||Similarity ^@ Belongs to the YdjC deacetylase family.|||Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides. http://togogenome.org/gene/9555:VASN ^@ http://purl.uniprot.org/uniprot/A0A096N9K5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:LOC100997503 ^@ http://purl.uniprot.org/uniprot/A0A2I3NEC0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space|||Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. http://togogenome.org/gene/9555:SLC7A11 ^@ http://purl.uniprot.org/uniprot/A0A096NG78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:GEM ^@ http://purl.uniprot.org/uniprot/A0A096NBY6 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/9555:CCND3 ^@ http://purl.uniprot.org/uniprot/A8MN33 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9555:RPS6KA3 ^@ http://purl.uniprot.org/uniprot/A0A8I5N0F6|||http://purl.uniprot.org/uniprot/A0A8I5NHC7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9555:NFYA ^@ http://purl.uniprot.org/uniprot/A0A096NI16|||http://purl.uniprot.org/uniprot/A0A2I3LDD7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NFYA/HAP2 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.|||Heterotrimer.|||Nucleus http://togogenome.org/gene/9555:AGPAT2 ^@ http://purl.uniprot.org/uniprot/A0A096NRS0 ^@ Domain|||Function|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/9555:PSMC3 ^@ http://purl.uniprot.org/uniprot/A0A096N8F7 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9555:LOC101015284 ^@ http://purl.uniprot.org/uniprot/A0A096MZA7 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9555:TMEM144 ^@ http://purl.uniprot.org/uniprot/A0A096MY72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM144 family.|||Membrane http://togogenome.org/gene/9555:MED9 ^@ http://purl.uniprot.org/uniprot/A0A096P318 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 9 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9555:RPL18 ^@ http://purl.uniprot.org/uniprot/A0A096MNV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL18 family.|||Rough endoplasmic reticulum http://togogenome.org/gene/9555:STXBP1 ^@ http://purl.uniprot.org/uniprot/A0A096P203|||http://purl.uniprot.org/uniprot/A0A2I3MJQ0 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9555:NLRP3 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y4Z4 ^@ Similarity ^@ Belongs to the NLRP family. http://togogenome.org/gene/9555:EML2 ^@ http://purl.uniprot.org/uniprot/A0A0A0MUS4|||http://purl.uniprot.org/uniprot/A0A2I3LHS3 ^@ Similarity ^@ Belongs to the WD repeat EMAP family. http://togogenome.org/gene/9555:TUBG1 ^@ http://purl.uniprot.org/uniprot/A0A096P5U1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin family.|||Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.|||centrosome http://togogenome.org/gene/9555:NSUN5 ^@ http://purl.uniprot.org/uniprot/A0A096MVF3 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/9555:TAF11 ^@ http://purl.uniprot.org/uniprot/A0A8I5NEF4 ^@ Similarity ^@ Belongs to the TAF11 family. http://togogenome.org/gene/9555:ANAPC10 ^@ http://purl.uniprot.org/uniprot/A0A096N869 ^@ Function|||Similarity ^@ Belongs to the APC10 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. http://togogenome.org/gene/9555:NXPE3 ^@ http://purl.uniprot.org/uniprot/A0A096MQN9 ^@ Similarity ^@ Belongs to the NXPE family. http://togogenome.org/gene/9555:LHFPL4 ^@ http://purl.uniprot.org/uniprot/A0A2I3N6B9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:CLUH ^@ http://purl.uniprot.org/uniprot/A0A096P2D4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CLU family.|||Cytoplasm|||Cytoplasmic granule|||mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis. http://togogenome.org/gene/9555:PTPRM ^@ http://purl.uniprot.org/uniprot/A0A096N2E3|||http://purl.uniprot.org/uniprot/A0A8I5NCP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.|||Membrane http://togogenome.org/gene/9555:FAM120C ^@ http://purl.uniprot.org/uniprot/A0A2I3M6R0 ^@ Similarity ^@ Belongs to the constitutive coactivator of PPAR-gamma family. http://togogenome.org/gene/9555:ENTPD5 ^@ http://purl.uniprot.org/uniprot/A0A2I3MSI4 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9555:TENT5B ^@ http://purl.uniprot.org/uniprot/A0A096MUR3 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/9555:NDUFA8 ^@ http://purl.uniprot.org/uniprot/A0A8I5NVG5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA8 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/9555:OVOL1 ^@ http://purl.uniprot.org/uniprot/A0A096NCN0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:GADD45G ^@ http://purl.uniprot.org/uniprot/A0A8I5R126 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/9555:IMPDH1 ^@ http://purl.uniprot.org/uniprot/A0A2I3N1L1 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.|||Nucleus http://togogenome.org/gene/9555:SSTR4 ^@ http://purl.uniprot.org/uniprot/A0A096NVS2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9555:PAF1 ^@ http://purl.uniprot.org/uniprot/A0A0A0MX55 ^@ Similarity ^@ Belongs to the PAF1 family. http://togogenome.org/gene/9555:NDRG4 ^@ http://purl.uniprot.org/uniprot/A0A2I3LD24|||http://purl.uniprot.org/uniprot/A0A2I3LPY9 ^@ Similarity ^@ Belongs to the NDRG family. http://togogenome.org/gene/9555:NDUFA2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LYX9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA2 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:PLSCR3 ^@ http://purl.uniprot.org/uniprot/A0A096P2P5 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/9555:RBM47 ^@ http://purl.uniprot.org/uniprot/A0A2I3M1E5|||http://purl.uniprot.org/uniprot/A0A2I3MYY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM RBM47 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:PKP1 ^@ http://purl.uniprot.org/uniprot/A0A096NPQ7 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/9555:UGT2B39 ^@ http://purl.uniprot.org/uniprot/D2SMM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9555:SNX33 ^@ http://purl.uniprot.org/uniprot/A0A096NMT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane http://togogenome.org/gene/9555:SMC6 ^@ http://purl.uniprot.org/uniprot/A0A096P005 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/9555:CNEP1R1 ^@ http://purl.uniprot.org/uniprot/A0A096NI63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNEP1R1 family.|||Cytoplasm|||Membrane|||Nucleus membrane http://togogenome.org/gene/9555:LOC100137203 ^@ http://purl.uniprot.org/uniprot/B0CM41 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. http://togogenome.org/gene/9555:PANX3 ^@ http://purl.uniprot.org/uniprot/A0A096N4L5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Structural component of the gap junctions and the hemichannels.|||gap junction http://togogenome.org/gene/9555:SLC27A4 ^@ http://purl.uniprot.org/uniprot/A0A2I3N730 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9555:ZHX1 ^@ http://purl.uniprot.org/uniprot/A0A096N8W0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZHX family.|||Nucleus http://togogenome.org/gene/9555:CCL25 ^@ http://purl.uniprot.org/uniprot/A0A8I5NYA0 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9555:KCNK13 ^@ http://purl.uniprot.org/uniprot/A0A8I5NXT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9555:ALKAL1 ^@ http://purl.uniprot.org/uniprot/A0A096N010 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALKAL family.|||Secreted http://togogenome.org/gene/9555:LOC100998364 ^@ http://purl.uniprot.org/uniprot/A0A2I3LD30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:SRFBP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LIE6 ^@ Function|||Subunit ^@ Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4.|||May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells. http://togogenome.org/gene/9555:XPO6 ^@ http://purl.uniprot.org/uniprot/A0A096NHJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:KCNH4 ^@ http://purl.uniprot.org/uniprot/A0A096P5S0 ^@ Subcellular Location Annotation|||Subunit ^@ Membrane|||The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. http://togogenome.org/gene/9555:RAN ^@ http://purl.uniprot.org/uniprot/A0A096N379 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ran family.|||GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.|||Nucleus http://togogenome.org/gene/9555:AMIGO3 ^@ http://purl.uniprot.org/uniprot/A0A096N7J4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. AMIGO family.|||Membrane http://togogenome.org/gene/9555:DYNLL1 ^@ http://purl.uniprot.org/uniprot/A0A8I5P1V4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.|||Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/9555:LIAS ^@ http://purl.uniprot.org/uniprot/A0A096NNZ7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Mitochondrion http://togogenome.org/gene/9555:TANGO6 ^@ http://purl.uniprot.org/uniprot/A0A096MNF5 ^@ Similarity ^@ Belongs to the Tango6 family. http://togogenome.org/gene/9555:RAB43 ^@ http://purl.uniprot.org/uniprot/A0A096N126 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane http://togogenome.org/gene/9555:PRUNE1 ^@ http://purl.uniprot.org/uniprot/A0A096NWS3 ^@ Similarity ^@ Belongs to the PPase class C family. Prune subfamily. http://togogenome.org/gene/9555:NKX3-2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NS89 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:CSTF2 ^@ http://purl.uniprot.org/uniprot/A0A096NCS8|||http://purl.uniprot.org/uniprot/A0A2I3MYS5|||http://purl.uniprot.org/uniprot/A0A2I3NGR2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:SNX25 ^@ http://purl.uniprot.org/uniprot/A0A2I3LH34 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9555:LOC101013709 ^@ http://purl.uniprot.org/uniprot/A0A096NCT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase VIIb family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:BCLAF3 ^@ http://purl.uniprot.org/uniprot/A0A096MXY3 ^@ Similarity ^@ Belongs to the BCLAF1/THRAP3 family. http://togogenome.org/gene/9555:FCGR3A ^@ http://purl.uniprot.org/uniprot/Q09TM2 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Cell membrane|||Forms a heterooligomeric complex with ITAM-containing signaling subunits, either a homodimer of CD247, a homodimer of FCER1G or a heterodimer of CD247 and FCER1G, to form a functional receptor complex. Interacts (via transmembrane domain) with signaling subunits; this interaction is a prerequisite for receptor complex expression on the cell surface and intracellular signal transduction. Binds the Fc region of antigen-complexed IgG with a preference for IgG1 and IgG3 isotypes (By similarity). Interacts with CD2; this interaction is involved in NK cell activation and cytotoxicity (By similarity). Interacts with S100A4; this interaction inhibits PKC-dependent phosphorylation of FCGR3A (By similarity).|||Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG1 and IgG2.|||Lymphocytes and monocytes.|||Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG). Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC). Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger (By similarity). Mediates IgG effector functions on natural killer (NK) cells. Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation. Involved in the generation of memory-like adaptive NK cells capable to produce high amounts of IFNG and to efficiently eliminate virus-infected cells via ADCC. Regulates NK cell survival and proliferation, in particular by preventing NK cell progenitor apoptosis (By similarity). Fc-binding subunit that associates with CD247 and/or FCER1G adapters to form functional signaling complexes. Following the engagement of antigen-IgG complexes, triggers phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapters with subsequent activation of phosphatidylinositol 3-kinase signaling and sustained elevation of intracellular calcium that ultimately drive NK cell activation. The ITAM-dependent signaling coupled to receptor phosphorylation by PKC mediates robust intracellular calcium flux that leads to production of pro-inflammatory cytokines, whereas in the absence of receptor phosphorylation it mainly activates phosphatidylinositol 3-kinase signaling leading to cell degranulation. Costimulates NK cells and trigger lysis of target cells independently of IgG binding (By similarity). Mediates the antitumor activities of therapeutic antibodies. Upon ligation on monocytes triggers TNFA-dependent ADCC of IgG-coated tumor cells (By similarity). Mediates enhanced ADCC in response to afucosylated IgGs (By similarity).|||Secreted|||Undergoes rapid ectodomain shedding upon NK cell stimulation. The soluble form is produced by a proteolytic cleavage mediated by ADAM17. Repeated stimulation causes receptor shedding, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells while avoiding activation-induced NK cell apoptosis. http://togogenome.org/gene/9555:OTUB2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MTU3 ^@ Similarity ^@ Belongs to the peptidase C65 family. http://togogenome.org/gene/9555:SFXN2 ^@ http://purl.uniprot.org/uniprot/A0A096P6F6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9555:SLC14A1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LF86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urea transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:SLC37A2 ^@ http://purl.uniprot.org/uniprot/A0A2I3MGI5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.|||Membrane http://togogenome.org/gene/9555:RPL38 ^@ http://purl.uniprot.org/uniprot/A0A2I3LG62 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL38 family. http://togogenome.org/gene/9555:H1-3 ^@ http://purl.uniprot.org/uniprot/A0A8I5NA22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9555:MYOZ1 ^@ http://purl.uniprot.org/uniprot/A0A096P4M9 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/9555:HTR5A ^@ http://purl.uniprot.org/uniprot/A0A096NZS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:PHOX2B ^@ http://purl.uniprot.org/uniprot/A0A096NPT4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:DDIT3 ^@ http://purl.uniprot.org/uniprot/A0A096NZ20 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bZIP family.|||Cytoplasm|||Heterodimer.|||Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.|||Nucleus|||Phosphorylation at serine residues by MAPK14 enhances its transcriptional activation activity while phosphorylation at serine residues by CK2 inhibits its transcriptional activation activity.|||Ubiquitinated, leading to its degradation by the proteasome. http://togogenome.org/gene/9555:LOC100997559 ^@ http://purl.uniprot.org/uniprot/A0A2I3M964 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9555:ARSI ^@ http://purl.uniprot.org/uniprot/A0A096MR34 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9555:PIK3CA ^@ http://purl.uniprot.org/uniprot/A0A2I3LHT4 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9555:FUNDC1 ^@ http://purl.uniprot.org/uniprot/A0A096NC13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FUN14 family.|||Mitochondrion outer membrane http://togogenome.org/gene/9555:PCSK2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LHF8 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9555:DNAJC2 ^@ http://purl.uniprot.org/uniprot/A0A096NGR0 ^@ Function|||Subcellular Location Annotation ^@ Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation.|||Nucleus|||cytosol http://togogenome.org/gene/9555:TUBB4A ^@ http://purl.uniprot.org/uniprot/A0A096NWZ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9555:TRIM5 ^@ http://purl.uniprot.org/uniprot/A7U0P5|||http://purl.uniprot.org/uniprot/Q5D7J2 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Autoubiquitinated in a RING finger- and UBE2D2-dependent manner. Monoubiquitinated by TRIM21. Deubiquitinated by Yersinia YopJ. Ubiquitination may not lead to proteasomal degradation (By similarity).|||Belongs to the TRIM/RBCC family.|||Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.|||Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2.|||Cytoplasm|||Degraded in a proteasome-independent fashion in the absence of viral infection but in a proteasome-dependent fashion following exposure to restriction sensitive virus.|||Nucleus|||The B box-type zinc finger domain and the coiled-coil domain contribute to the higher and low order multimerization respectively which is essential for restriction activity. The coiled coil domain is important for higher order multimerization by promoting the initial dimerization.|||The B30.2/SPRY domain acts as a capsid recognition domain. Polymorphisms in this domain explain the observed species-specific differences among orthologs (By similarity).|||The RING-type zinc finger domain confers E3 ubiquitin ligase activity and is essential for retrovirus restriction activity, autoubiquitination and higher-order multimerization. http://togogenome.org/gene/9555:SRM ^@ http://purl.uniprot.org/uniprot/A0A096NPX7 ^@ Similarity ^@ Belongs to the spermidine/spermine synthase family. http://togogenome.org/gene/9555:TUBA8 ^@ http://purl.uniprot.org/uniprot/A0A2I3LCG6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9555:ERBIN ^@ http://purl.uniprot.org/uniprot/A0A096MTT1|||http://purl.uniprot.org/uniprot/A0A2I3MAP2|||http://purl.uniprot.org/uniprot/A0A8I5R141 ^@ Similarity ^@ Belongs to the LAP (LRR and PDZ) protein family. http://togogenome.org/gene/9555:TMEM165 ^@ http://purl.uniprot.org/uniprot/A0A096NAY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GDT1 family.|||Membrane http://togogenome.org/gene/9555:PSMC1 ^@ http://purl.uniprot.org/uniprot/A0A096N5G5 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9555:SUV39H2 ^@ http://purl.uniprot.org/uniprot/A0A096P3I3|||http://purl.uniprot.org/uniprot/A0A2I3NBF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.|||Nucleus|||centromere http://togogenome.org/gene/9555:SLC22A12 ^@ http://purl.uniprot.org/uniprot/A0A096NXY8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:ARSK ^@ http://purl.uniprot.org/uniprot/A0A096MMD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Lysosome http://togogenome.org/gene/9555:IPO13 ^@ http://purl.uniprot.org/uniprot/A0A2I3N6N3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the importin beta family.|||Cytoplasm|||Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.|||Nucleus http://togogenome.org/gene/9555:PLD5 ^@ http://purl.uniprot.org/uniprot/A0A096MYM3 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/9555:LOC101020949 ^@ http://purl.uniprot.org/uniprot/A0A096NYD4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS1 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.|||Cytoplasm|||May play a role during erythropoiesis through regulation of transcription factor DDIT3.|||Nucleus|||nucleolus http://togogenome.org/gene/9555:PROZ ^@ http://purl.uniprot.org/uniprot/A9X173 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:FTO ^@ http://purl.uniprot.org/uniprot/A0A2I3MI88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fto family.|||Cytoplasm|||Nucleus speckle http://togogenome.org/gene/9555:RO60 ^@ http://purl.uniprot.org/uniprot/A0A096N4D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ro 60 kDa family.|||Cytoplasm http://togogenome.org/gene/9555:STT3A ^@ http://purl.uniprot.org/uniprot/A0A096NAD0|||http://purl.uniprot.org/uniprot/A0A2I3LRP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/9555:CCT5 ^@ http://purl.uniprot.org/uniprot/A0A096MWK0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.|||Cytoplasm http://togogenome.org/gene/9555:CUL7 ^@ http://purl.uniprot.org/uniprot/A0A8I5N4Z2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cullin family.|||Cytoplasm http://togogenome.org/gene/9555:LOC101010375 ^@ http://purl.uniprot.org/uniprot/A0A2I3NDR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/9555:RIC8B ^@ http://purl.uniprot.org/uniprot/A0A096MRK9|||http://purl.uniprot.org/uniprot/A0A2I3LE00|||http://purl.uniprot.org/uniprot/A0A2I3M430|||http://purl.uniprot.org/uniprot/A0A2I3MHK2|||http://purl.uniprot.org/uniprot/A0A8I5R6V9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the synembryn family.|||Cytoplasm|||Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.|||Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. http://togogenome.org/gene/9555:GFRA3 ^@ http://purl.uniprot.org/uniprot/A0A096MUN3 ^@ Similarity ^@ Belongs to the GDNFR family. http://togogenome.org/gene/9555:TRIM6 ^@ http://purl.uniprot.org/uniprot/A0A096N4B9|||http://purl.uniprot.org/uniprot/A9L8Z2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:VPS33A ^@ http://purl.uniprot.org/uniprot/A0A096NFS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STXBP/unc-18/SEC1 family.|||Early endosome|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||clathrin-coated vesicle http://togogenome.org/gene/9555:TPH2 ^@ http://purl.uniprot.org/uniprot/A0A096N129 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/9555:IL3 ^@ http://purl.uniprot.org/uniprot/A9CB22 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-3 family.|||Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB. Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program. Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK.|||Secreted http://togogenome.org/gene/9555:IL21 ^@ http://purl.uniprot.org/uniprot/A0A8I5NTL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Secreted http://togogenome.org/gene/9555:MAP3K9 ^@ http://purl.uniprot.org/uniprot/A0A096NVW0 ^@ Activity Regulation|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Homodimer.|||Homodimerization via the leucine zipper domains is required for autophosphorylation. http://togogenome.org/gene/9555:LOC101014319 ^@ http://purl.uniprot.org/uniprot/A0A096NKE0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9555:RABAC1 ^@ http://purl.uniprot.org/uniprot/A0A0A0MUQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/9555:ANKRD13A ^@ http://purl.uniprot.org/uniprot/A0A096NC28 ^@ Function|||Subcellular Location Annotation ^@ Endosome|||Late endosome|||Membrane|||Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. http://togogenome.org/gene/9555:B3GALT2 ^@ http://purl.uniprot.org/uniprot/A0A096MMX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9555:EFNB3 ^@ http://purl.uniprot.org/uniprot/A0A8I5NRR2 ^@ Caution|||Similarity ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:TMEM182 ^@ http://purl.uniprot.org/uniprot/A0A8I5P4B2|||http://purl.uniprot.org/uniprot/A0A8I5R8Z1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM182 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:OSBPL8 ^@ http://purl.uniprot.org/uniprot/A0A2I3NE38 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9555:B2M ^@ http://purl.uniprot.org/uniprot/Q6T672 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta-2-microglobulin family.|||Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).|||Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules (By similarity).|||Secreted http://togogenome.org/gene/9555:MED7 ^@ http://purl.uniprot.org/uniprot/A0A096NPJ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 7 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9555:CPLX1 ^@ http://purl.uniprot.org/uniprot/A0A096MLC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9555:SEPTIN4 ^@ http://purl.uniprot.org/uniprot/A0A096P4U7|||http://purl.uniprot.org/uniprot/A0A2I3LLF1|||http://purl.uniprot.org/uniprot/A0A2I3M828 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9555:LOC100999053 ^@ http://purl.uniprot.org/uniprot/A0A2I3NH29 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/9555:CAMK1 ^@ http://purl.uniprot.org/uniprot/A0A096MM11|||http://purl.uniprot.org/uniprot/A0A8I5R6A0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:TRIM7 ^@ http://purl.uniprot.org/uniprot/A0A2I3MG11 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9555:XCR1 ^@ http://purl.uniprot.org/uniprot/A0A096N733 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9555:ELOVL5 ^@ http://purl.uniprot.org/uniprot/A0A8I5NMB2|||http://purl.uniprot.org/uniprot/A0A8I5NS71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Belongs to the ELO family. ELOVL5 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Membrane|||dendrite http://togogenome.org/gene/9555:OCLN ^@ http://purl.uniprot.org/uniprot/A0A096N8G9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Cell membrane|||May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.|||Membrane|||tight junction http://togogenome.org/gene/9555:KPNB1 ^@ http://purl.uniprot.org/uniprot/A0A096P541 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the importin beta family. Importin beta-1 subfamily.|||Cytoplasm http://togogenome.org/gene/9555:PTMA ^@ http://purl.uniprot.org/uniprot/A0A2I3MH52 ^@ Similarity ^@ Belongs to the pro/parathymosin family. http://togogenome.org/gene/9555:SH3GLB1 ^@ http://purl.uniprot.org/uniprot/A0A096NBE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Golgi apparatus membrane|||Midbody|||Mitochondrion outer membrane|||autophagosome membrane http://togogenome.org/gene/9555:GJD3 ^@ http://purl.uniprot.org/uniprot/A0A096P5G8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9555:AVPR2 ^@ http://purl.uniprot.org/uniprot/A9CB48 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.|||Membrane http://togogenome.org/gene/9555:PFDN1 ^@ http://purl.uniprot.org/uniprot/A0A096N4N6 ^@ Function|||Similarity ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. http://togogenome.org/gene/9555:MAPK9 ^@ http://purl.uniprot.org/uniprot/A0A2I3LEY1|||http://purl.uniprot.org/uniprot/A0A2I3M9T9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/9555:UNK ^@ http://purl.uniprot.org/uniprot/A0A2I3LCR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unkempt family.|||Cytoplasm http://togogenome.org/gene/9555:CCR1 ^@ http://purl.uniprot.org/uniprot/A0A8I5N3W8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9555:AMT ^@ http://purl.uniprot.org/uniprot/A0A096MSU5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvT family.|||Mitochondrion|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/9555:GNPDA2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NPN2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/9555:GGA2 ^@ http://purl.uniprot.org/uniprot/A0A096NHE7|||http://purl.uniprot.org/uniprot/A0A2I3M6H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GGA protein family.|||Early endosome membrane|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9555:RPL10L ^@ http://purl.uniprot.org/uniprot/A0A8I5QZM7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/9555:LOC101019786 ^@ http://purl.uniprot.org/uniprot/A0A8I5NJV1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:KDM5B ^@ http://purl.uniprot.org/uniprot/A0A2I3LVI6 ^@ Similarity ^@ Belongs to the JARID1 histone demethylase family. http://togogenome.org/gene/9555:TRAPPC13 ^@ http://purl.uniprot.org/uniprot/A0A096N7Y3|||http://purl.uniprot.org/uniprot/A0A2I3M197 ^@ Similarity|||Subunit ^@ Belongs to the TRAPPC13 family.|||Part of the multisubunit TRAPP (transport protein particle) complex. http://togogenome.org/gene/9555:SOSTDC1 ^@ http://purl.uniprot.org/uniprot/A0A096N248 ^@ Caution|||Similarity ^@ Belongs to the sclerostin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:HOXC9 ^@ http://purl.uniprot.org/uniprot/A0A8I5NHN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/9555:SLC29A1 ^@ http://purl.uniprot.org/uniprot/A0A096NIK3|||http://purl.uniprot.org/uniprot/A0A2I3LSG1 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Basolateral cell membrane|||Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9555:FUT7 ^@ http://purl.uniprot.org/uniprot/A0A8I5NBT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9555:TOR3A ^@ http://purl.uniprot.org/uniprot/A0A096N1Q9 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. Torsin subfamily. http://togogenome.org/gene/9555:GGA3 ^@ http://purl.uniprot.org/uniprot/A0A096NSU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GGA protein family.|||Early endosome membrane|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9555:PPIH ^@ http://purl.uniprot.org/uniprot/A0A096MU77 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9555:SGTA ^@ http://purl.uniprot.org/uniprot/A0A0A0MUS7 ^@ Similarity ^@ Belongs to the SGT family. http://togogenome.org/gene/9555:TRAPPC2L ^@ http://purl.uniprot.org/uniprot/A0A096NFG2|||http://purl.uniprot.org/uniprot/A0A8I5ND35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||perinuclear region http://togogenome.org/gene/9555:CD46 ^@ http://purl.uniprot.org/uniprot/A0A096NAP4|||http://purl.uniprot.org/uniprot/A0A2I3LWZ4|||http://purl.uniprot.org/uniprot/A0A2I3M7U9|||http://purl.uniprot.org/uniprot/A0A2I3MI60 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||acrosome inner membrane http://togogenome.org/gene/9555:PRKN ^@ http://purl.uniprot.org/uniprot/A0A096MX93 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RBR family. Parkin subfamily.|||Forms an E3 ubiquitin ligase complex.|||Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.|||Mitochondrion|||cytosol http://togogenome.org/gene/9555:ALOX5AP ^@ http://purl.uniprot.org/uniprot/A0A096MLB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9555:EIPR1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MU98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat EIPR1 family.|||trans-Golgi network http://togogenome.org/gene/9555:AGO4 ^@ http://purl.uniprot.org/uniprot/A0A096N7N6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argonaute family. Ago subfamily.|||Interacts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B. Interacts with ZFP36.|||P-body|||Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. http://togogenome.org/gene/9555:PPDPFL ^@ http://purl.uniprot.org/uniprot/A0A096NPP3 ^@ Similarity ^@ Belongs to the PPDPF family. http://togogenome.org/gene/9555:HVCN1 ^@ http://purl.uniprot.org/uniprot/A0A096NE62 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the hydrogen channel family.|||Homodimer.|||Membrane http://togogenome.org/gene/9555:ST8SIA5 ^@ http://purl.uniprot.org/uniprot/A0A096MYU8|||http://purl.uniprot.org/uniprot/A0A2I3MQT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9555:WNT11 ^@ http://purl.uniprot.org/uniprot/A0A096N3G4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9555:WDR83OS ^@ http://purl.uniprot.org/uniprot/A0A8I5NQE5 ^@ Similarity ^@ Belongs to the Asterix family. http://togogenome.org/gene/9555:PEX3 ^@ http://purl.uniprot.org/uniprot/A0A2I3LS74 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with PEX19.|||Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.|||Peroxisome membrane http://togogenome.org/gene/9555:UBE2E1 ^@ http://purl.uniprot.org/uniprot/A0A2I3M7H8 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9555:KLC4 ^@ http://purl.uniprot.org/uniprot/A0A2I3LIA9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kinesin light chain family.|||Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.|||Oligomeric complex composed of two heavy chains and two light chains.|||cytoskeleton http://togogenome.org/gene/9555:LSM12 ^@ http://purl.uniprot.org/uniprot/A0A096P5Z4 ^@ Similarity ^@ Belongs to the LSM12 family. http://togogenome.org/gene/9555:GATA1 ^@ http://purl.uniprot.org/uniprot/A0A096N377 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:HS3ST4 ^@ http://purl.uniprot.org/uniprot/A0A096MY37 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9555:KCNMB1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NIJ6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KCNMB (TC 8.A.14.1) family.|||Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.|||Membrane|||N-glycosylated.|||Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. http://togogenome.org/gene/9555:P2RX3 ^@ http://purl.uniprot.org/uniprot/A0A2I3LT80 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9555:SMAD2 ^@ http://purl.uniprot.org/uniprot/A0A096NP77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:DDB2 ^@ http://purl.uniprot.org/uniprot/A0A096N3C6|||http://purl.uniprot.org/uniprot/A0A2I3NC36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat DDB2/WDR76 family.|||Nucleus http://togogenome.org/gene/9555:SLC39A5 ^@ http://purl.uniprot.org/uniprot/A0A096MPW9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:ACSL6 ^@ http://purl.uniprot.org/uniprot/A9CB21 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.|||Endoplasmic reticulum membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9555:MARK4 ^@ http://purl.uniprot.org/uniprot/A0A2I3LQ00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||dendrite http://togogenome.org/gene/9555:ALG14 ^@ http://purl.uniprot.org/uniprot/A0A096NGK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG14 family.|||Endoplasmic reticulum membrane|||Membrane|||Nucleus membrane http://togogenome.org/gene/9555:OLR89 ^@ http://purl.uniprot.org/uniprot/A9L8X0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:ANKS1A ^@ http://purl.uniprot.org/uniprot/A0A2I3MGF3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:TRIM3 ^@ http://purl.uniprot.org/uniprot/A0A2I3M2A2 ^@ Similarity ^@ Belongs to the TRIM/RBCC family. http://togogenome.org/gene/9555:HSBP1 ^@ http://purl.uniprot.org/uniprot/A0A096NFZ5 ^@ Similarity ^@ Belongs to the HSBP1 family. http://togogenome.org/gene/9555:NBL1 ^@ http://purl.uniprot.org/uniprot/A0A096NEP8|||http://purl.uniprot.org/uniprot/A0A2I3N3V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Secreted http://togogenome.org/gene/9555:LOC101024697 ^@ http://purl.uniprot.org/uniprot/A0A096NJQ1 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9555:GLYAT ^@ http://purl.uniprot.org/uniprot/A0A096MPA2 ^@ Similarity ^@ Belongs to the glycine N-acyltransferase family. http://togogenome.org/gene/9555:CDADC1 ^@ http://purl.uniprot.org/uniprot/A0A096NF63|||http://purl.uniprot.org/uniprot/A0A2I3LY28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||Cytoplasm http://togogenome.org/gene/9555:GPD1 ^@ http://purl.uniprot.org/uniprot/A0A096N5Z3 ^@ Similarity ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/9555:STAG3 ^@ http://purl.uniprot.org/uniprot/A0A096NFG1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||centromere http://togogenome.org/gene/9555:RDX ^@ http://purl.uniprot.org/uniprot/A0A096MPS5 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/9555:FOXP2 ^@ http://purl.uniprot.org/uniprot/A0A096NFI9|||http://purl.uniprot.org/uniprot/A9RAA3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:EIF3M ^@ http://purl.uniprot.org/uniprot/A0A2I3N3J9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Belongs to the eIF-3 subunit M family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm http://togogenome.org/gene/9555:HOXA5 ^@ http://purl.uniprot.org/uniprot/A9L940 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9555:AAR2 ^@ http://purl.uniprot.org/uniprot/A0A096NUK8 ^@ Function|||Similarity ^@ Belongs to the AAR2 family.|||Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. http://togogenome.org/gene/9555:PPP1R10 ^@ http://purl.uniprot.org/uniprot/A0A8I5NHY1 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers. http://togogenome.org/gene/9555:GPRC5C ^@ http://purl.uniprot.org/uniprot/A0A8I5N7X2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9555:SIDT2 ^@ http://purl.uniprot.org/uniprot/A0A096N708 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SID1 family.|||Membrane http://togogenome.org/gene/9555:DONSON ^@ http://purl.uniprot.org/uniprot/A9CB02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DONSON family.|||Nucleus http://togogenome.org/gene/9555:FAM83E ^@ http://purl.uniprot.org/uniprot/A0A0A0MXJ1 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9555:HNRNPF ^@ http://purl.uniprot.org/uniprot/A0A096ND72 ^@ Subcellular Location Annotation ^@ nucleoplasm http://togogenome.org/gene/9555:RIOK2 ^@ http://purl.uniprot.org/uniprot/A0A096NES2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/9555:SLC8A3 ^@ http://purl.uniprot.org/uniprot/A0A096NVV2|||http://purl.uniprot.org/uniprot/A0A2I3LFR2|||http://purl.uniprot.org/uniprot/A0A8I5N0A9|||http://purl.uniprot.org/uniprot/A0A8I5N7Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:FBN2 ^@ http://purl.uniprot.org/uniprot/A0A096MRY0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fibrillin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9555:ROCK2 ^@ http://purl.uniprot.org/uniprot/A0A096NJ57 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by RHOA binding. Inhibited by Y-27632.|||Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.|||Cell membrane|||Homodimer.|||Membrane|||Nucleus|||Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.|||centrosome http://togogenome.org/gene/9555:RPL30 ^@ http://purl.uniprot.org/uniprot/A0A2I3LTH8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/9555:TMEM265 ^@ http://purl.uniprot.org/uniprot/A0A2I3MPH4 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9555:PVALB ^@ http://purl.uniprot.org/uniprot/A0A8I5P2D3 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/9555:USP5 ^@ http://purl.uniprot.org/uniprot/A0A096NXI9 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9555:FLOT1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LK29 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily.|||Cell membrane|||Endosome|||Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.|||May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.|||Membrane|||Membrane raft|||caveola http://togogenome.org/gene/9555:ADAM8 ^@ http://purl.uniprot.org/uniprot/A0A096NSY3|||http://purl.uniprot.org/uniprot/A0A2I3MWQ9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:CXCR4 ^@ http://purl.uniprot.org/uniprot/P56491 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell junction|||Cell membrane|||Early endosome|||Late endosome|||Lysosome|||Monomer. Can form homodimers. Interacts with CD164. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARR3; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts with RNF113A; the interaction, enhanced by CXCL12, promotes CXCR4 ubiquitination and subsequent degradation. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, promotes CXCR4 ubiquitination and leads to its degradation. Interacts with extracellular ubiquitin. Interacts with DBN1; this interaction is enhanced by antigenic stimulation. Following LPS binding, may form a complex with GDF5, HSP90AA1 and HSPA8.|||O- and N-glycosylated. N-glycosylation can mask coreceptor function. The O-glycosylation chondroitin sulfate attachment does not affect interaction with CXCL12/SDF-1alpha nor its coreceptor activity.|||Phosphorylated on agonist stimulation. Rapidly phosphorylated on serine and threonine residues in the C-terminal. Phosphorylation at Ser-324 and Ser-325 leads to recruitment of ITCH, ubiquitination and protein degradation.|||Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity).|||Sulfation is required for efficient binding of CXCL12/SDF-1alpha and promotes its dimerization.|||Ubiquitinated after ligand binding, leading to its degradation. Ubiquitinated by ITCH at the cell membrane on agonist stimulation. The ubiquitin-dependent mechanism, endosomal sorting complex required for transport (ESCRT), then targets CXCR4 for lysosomal degradation. This process is dependent also on prior Ser-/Thr-phosphorylation in the C-terminal of CXCR4. Also binding of ARRB1 to STAM negatively regulates CXCR4 sorting to lysosomes though modulating ubiquitination of SFR5S. http://togogenome.org/gene/9555:ABITRAM ^@ http://purl.uniprot.org/uniprot/A0A096P0Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABITRAM family.|||growth cone|||lamellipodium http://togogenome.org/gene/9555:RPL36AL ^@ http://purl.uniprot.org/uniprot/A0A096NUT3|||http://purl.uniprot.org/uniprot/A9L948 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL42 family.|||Component of the large ribosomal subunit.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||Cytoplasm http://togogenome.org/gene/9555:GSTA4 ^@ http://purl.uniprot.org/uniprot/A0A096NJ89 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/9555:ARPC1B ^@ http://purl.uniprot.org/uniprot/A0A096NQ28 ^@ Function|||Similarity ^@ Belongs to the WD repeat ARPC1 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. http://togogenome.org/gene/9555:CALCA ^@ http://purl.uniprot.org/uniprot/A0A096MYB1|||http://purl.uniprot.org/uniprot/A0A096NGD0 ^@ Similarity ^@ Belongs to the calcitonin family. http://togogenome.org/gene/9555:PADI2 ^@ http://purl.uniprot.org/uniprot/A0A096MV57 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein arginine deiminase family.|||Catalyzes the deimination of arginine residues of proteins.|||Cytoplasm http://togogenome.org/gene/9555:PMM1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NNC7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic PMM family.|||Cytoplasm|||Homodimer.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/9555:HYLS1 ^@ http://purl.uniprot.org/uniprot/A0A096MS45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HYLS1 family.|||centriole|||cilium http://togogenome.org/gene/9555:RPS27A ^@ http://purl.uniprot.org/uniprot/A0A2I3LH01 ^@ Similarity ^@ In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.|||In the N-terminal section; belongs to the ubiquitin family. http://togogenome.org/gene/9555:TNFAIP1 ^@ http://purl.uniprot.org/uniprot/A0A096P384 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BACURD family.|||Cell membrane http://togogenome.org/gene/9555:ELL ^@ http://purl.uniprot.org/uniprot/A0A0A0MXK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Nucleus http://togogenome.org/gene/9555:UPF3B ^@ http://purl.uniprot.org/uniprot/A0A096NAQ0|||http://purl.uniprot.org/uniprot/A0A2I3M4B7 ^@ Similarity ^@ Belongs to the RENT3 family. http://togogenome.org/gene/9555:ART1 ^@ http://purl.uniprot.org/uniprot/A0A096N4Y4 ^@ Similarity ^@ Belongs to the Arg-specific ADP-ribosyltransferase family. http://togogenome.org/gene/9555:UBE2U ^@ http://purl.uniprot.org/uniprot/A0A2I3NC58 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9555:YARS1 ^@ http://purl.uniprot.org/uniprot/A0A096N3E1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Nucleus http://togogenome.org/gene/9555:NELL2 ^@ http://purl.uniprot.org/uniprot/A0A2I3M5V9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:FOXP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3LY31 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:KCNB2 ^@ http://purl.uniprot.org/uniprot/A0A096MKX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.|||Cell membrane|||Membrane|||Perikaryon|||dendrite http://togogenome.org/gene/9555:EMP3 ^@ http://purl.uniprot.org/uniprot/A0A0A0MU61 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Probably involved in cell proliferation and cell-cell interactions. http://togogenome.org/gene/9555:E2F5 ^@ http://purl.uniprot.org/uniprot/A0A096MNW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9555:NOC3L ^@ http://purl.uniprot.org/uniprot/A0A096P5Q3|||http://purl.uniprot.org/uniprot/A0A8I5NS84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CBF/MAK21 family.|||nucleolus http://togogenome.org/gene/9555:AKIRIN1 ^@ http://purl.uniprot.org/uniprot/A0A096NA47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus http://togogenome.org/gene/9555:L1CAM ^@ http://purl.uniprot.org/uniprot/A9CB47 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. http://togogenome.org/gene/9555:NUP50 ^@ http://purl.uniprot.org/uniprot/A0A2I3M7T7 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/9555:LOC101004188 ^@ http://purl.uniprot.org/uniprot/A0A0A0MWA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:RXRG ^@ http://purl.uniprot.org/uniprot/A0A096MW06 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.|||Homodimer. Heterodimer; with a rar molecule.|||Nucleus|||Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. http://togogenome.org/gene/9555:PHKG1 ^@ http://purl.uniprot.org/uniprot/A0A096NG96 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily.|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin. http://togogenome.org/gene/9555:INO80 ^@ http://purl.uniprot.org/uniprot/A0A096NTL4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.|||Belongs to the SNF2/RAD54 helicase family.|||Component of the INO80 chromatin-remodeling complex.|||Nucleus|||The DBINO region is involved in binding to DNA. http://togogenome.org/gene/9555:ASIC5 ^@ http://purl.uniprot.org/uniprot/A0A096NQP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.|||Membrane http://togogenome.org/gene/9555:LOC101017105 ^@ http://purl.uniprot.org/uniprot/A0A096MZA0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:LOC101010936 ^@ http://purl.uniprot.org/uniprot/A0A8I5N4T0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:TRAF6 ^@ http://purl.uniprot.org/uniprot/A0A096MX12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family. A subfamily.|||Lipid droplet|||Nucleus|||cell cortex http://togogenome.org/gene/9555:SGMS2 ^@ http://purl.uniprot.org/uniprot/A0A096MZC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/9555:IFT46 ^@ http://purl.uniprot.org/uniprot/A0A096ML21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFT46 family.|||cilium|||cilium basal body http://togogenome.org/gene/9555:ZSCAN29 ^@ http://purl.uniprot.org/uniprot/A0A096NSP3|||http://purl.uniprot.org/uniprot/A9X1B1 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9555:SNX8 ^@ http://purl.uniprot.org/uniprot/A0A096NQJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane http://togogenome.org/gene/9555:LOC100998784 ^@ http://purl.uniprot.org/uniprot/A0A2I3MSK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uricase family.|||Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.|||Peroxisome http://togogenome.org/gene/9555:PCYT1A ^@ http://purl.uniprot.org/uniprot/A0A2I3MY35 ^@ Function|||Similarity ^@ Belongs to the cytidylyltransferase family.|||Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. http://togogenome.org/gene/9555:KLC1 ^@ http://purl.uniprot.org/uniprot/A0A096NJZ3|||http://purl.uniprot.org/uniprot/A0A2I3LN97|||http://purl.uniprot.org/uniprot/A0A2I3LUC3|||http://purl.uniprot.org/uniprot/A0A2I3MD17|||http://purl.uniprot.org/uniprot/A0A2I3MUI4|||http://purl.uniprot.org/uniprot/A0A2I3N524 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kinesin light chain family.|||Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.|||Oligomeric complex composed of two heavy chains and two light chains.|||cytoskeleton http://togogenome.org/gene/9555:SH3RF1 ^@ http://purl.uniprot.org/uniprot/A0A096NFL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SH3RF family.|||lamellipodium|||perinuclear region|||trans-Golgi network http://togogenome.org/gene/9555:OLFML3 ^@ http://purl.uniprot.org/uniprot/A0A096MKK3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:LOC101020722 ^@ http://purl.uniprot.org/uniprot/A0A096NB32 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9555:IL18 ^@ http://purl.uniprot.org/uniprot/A0A2I3NE92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Cytoplasm|||Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.|||Secreted http://togogenome.org/gene/9555:LOC101021227 ^@ http://purl.uniprot.org/uniprot/A0A8I5R6T8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:ATG9B ^@ http://purl.uniprot.org/uniprot/A0A096NRL4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.|||Preautophagosomal structure membrane http://togogenome.org/gene/9555:DPY30 ^@ http://purl.uniprot.org/uniprot/A0A096NAA2 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/9555:MARVELD2 ^@ http://purl.uniprot.org/uniprot/A0A096MKZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9555:S100A2 ^@ http://purl.uniprot.org/uniprot/A0A2I3NCR0 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9555:BLOC1S2 ^@ http://purl.uniprot.org/uniprot/A0A8I5NZL9|||http://purl.uniprot.org/uniprot/A0A8I5R6Z4 ^@ Similarity ^@ Belongs to the BLOC1S2 family. http://togogenome.org/gene/9555:BTDB ^@ http://purl.uniprot.org/uniprot/B6ULW5 ^@ Function|||PTM|||Similarity|||Subunit ^@ BTD-1 and BTD-2 have antimicrobial activity against the Gram-negative bacterium E.coli ML35, the Gram-positive bacterium S.aureus 502a, and the fungus C.albicans 16820. BTD-2 is more effective against E.coli than BTD-1.|||BTD-1 is a cyclic heterodimer composed of subunits A and B; disulfide-linked. BTD-2 is a cyclic homodimer composed of two subunits B; disulfide-linked.|||Belongs to the alpha-defensin family. Theta subfamily.|||Forms a cyclic peptide with subunit A (BTD-1), or subunit B (BTD-2). An additional intersubunit disulfide bond is formed. http://togogenome.org/gene/9555:ACADVL ^@ http://purl.uniprot.org/uniprot/A0A096P2M9 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9555:PSKH1 ^@ http://purl.uniprot.org/uniprot/A0A096N2R9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9555:MAPK8IP3 ^@ http://purl.uniprot.org/uniprot/A0A096NKW5|||http://purl.uniprot.org/uniprot/A0A2I3MXH6 ^@ Similarity ^@ Belongs to the JIP scaffold family. http://togogenome.org/gene/9555:CLDN12 ^@ http://purl.uniprot.org/uniprot/B0CM28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Membrane|||tight junction http://togogenome.org/gene/9555:MAOB ^@ http://purl.uniprot.org/uniprot/A0A096P0S6 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/9555:TREH ^@ http://purl.uniprot.org/uniprot/A0A096N7G8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 37 family. http://togogenome.org/gene/9555:BCCIP ^@ http://purl.uniprot.org/uniprot/A0A096NSQ4|||http://purl.uniprot.org/uniprot/A0A2I3MEI1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCP1 family.|||May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).|||Nucleus|||spindle pole http://togogenome.org/gene/9555:STX18 ^@ http://purl.uniprot.org/uniprot/A0A8I5N464 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Endoplasmic reticulum membrane|||Membrane|||Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. http://togogenome.org/gene/9555:MYBL2 ^@ http://purl.uniprot.org/uniprot/A0A096NXB2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:EXOSC9 ^@ http://purl.uniprot.org/uniprot/A0A096N1X9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9555:SMS ^@ http://purl.uniprot.org/uniprot/A0A096N445 ^@ Similarity ^@ Belongs to the spermidine/spermine synthase family. http://togogenome.org/gene/9555:MAK16 ^@ http://purl.uniprot.org/uniprot/A0A096NYI0 ^@ Similarity ^@ Belongs to the MAK16 family. http://togogenome.org/gene/9555:PTK7 ^@ http://purl.uniprot.org/uniprot/A0A096NIB0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:P2RY1 ^@ http://purl.uniprot.org/uniprot/A0A096MLQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:SSRP1 ^@ http://purl.uniprot.org/uniprot/A0A096NBC7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SSRP1 family.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Nucleus http://togogenome.org/gene/9555:CHRNB4 ^@ http://purl.uniprot.org/uniprot/A0A096NMW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9555:WNT2 ^@ http://purl.uniprot.org/uniprot/A0M8S1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).|||Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.|||Secreted|||extracellular matrix http://togogenome.org/gene/9555:SPNS1 ^@ http://purl.uniprot.org/uniprot/A0A096NHK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.|||Membrane http://togogenome.org/gene/9555:MPPED2 ^@ http://purl.uniprot.org/uniprot/A0A2I3LUA5 ^@ Similarity ^@ Belongs to the UPF0046 family. http://togogenome.org/gene/9555:KDELR2 ^@ http://purl.uniprot.org/uniprot/A0A096MVF9|||http://purl.uniprot.org/uniprot/A0A2I3M3E4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:KCNH7 ^@ http://purl.uniprot.org/uniprot/A0A2I3MBJ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:RXFP4 ^@ http://purl.uniprot.org/uniprot/A0A096NDZ8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9555:ZC3H12A ^@ http://purl.uniprot.org/uniprot/A0A096MTN7 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/9555:SUPT3H ^@ http://purl.uniprot.org/uniprot/A0A2I3LH29 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:MEIS1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NIK4|||http://purl.uniprot.org/uniprot/A0A8I5R6B3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/9555:NAPG ^@ http://purl.uniprot.org/uniprot/A0A2I3M579 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/9555:TIMELESS ^@ http://purl.uniprot.org/uniprot/A0A096NH10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the timeless family.|||Nucleus http://togogenome.org/gene/9555:ENTPD4 ^@ http://purl.uniprot.org/uniprot/A0A096MXL2 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9555:YIF1A ^@ http://purl.uniprot.org/uniprot/A0A096MQQ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIF1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Has a role in transport between endoplasmic reticulum and Golgi.|||Membrane http://togogenome.org/gene/9555:STAT1 ^@ http://purl.uniprot.org/uniprot/A0A096MQY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:EFNA1 ^@ http://purl.uniprot.org/uniprot/A0A096N996 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:FGF5 ^@ http://purl.uniprot.org/uniprot/A0A096N9F0 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9555:NADSYN1 ^@ http://purl.uniprot.org/uniprot/A0A096MPW7 ^@ Similarity|||Subunit ^@ Homohexamer.|||In the C-terminal section; belongs to the NAD synthetase family. http://togogenome.org/gene/9555:SESN2 ^@ http://purl.uniprot.org/uniprot/A0A096NFP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/9555:AP5M1 ^@ http://purl.uniprot.org/uniprot/A0A8I5NGV6 ^@ Subcellular Location Annotation|||Subunit ^@ Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane|||Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1. http://togogenome.org/gene/9555:HSDL1 ^@ http://purl.uniprot.org/uniprot/A0A096N5G0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9555:LOC101003561 ^@ http://purl.uniprot.org/uniprot/A0A096N4Z3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:MRE11 ^@ http://purl.uniprot.org/uniprot/A0A096NB40 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MRE11/RAD32 family.|||Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.|||Nucleus http://togogenome.org/gene/9555:SLC7A1 ^@ http://purl.uniprot.org/uniprot/A0A8I5N250 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:LOC101013819 ^@ http://purl.uniprot.org/uniprot/A0A2I3LZ64 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 6c family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/9555:NAB2 ^@ http://purl.uniprot.org/uniprot/A0A096NQB2|||http://purl.uniprot.org/uniprot/A0A096NU99 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAB family.|||Homomultimers may associate with EGR1 bound to DNA.|||Nucleus http://togogenome.org/gene/9555:LOC101019499 ^@ http://purl.uniprot.org/uniprot/A0A8I5R2I8 ^@ Similarity ^@ Belongs to the cytochrome c oxidase VIIa family. http://togogenome.org/gene/9555:TRMT6 ^@ http://purl.uniprot.org/uniprot/A0A096NVF7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRM6/GCD10 family.|||Heterotetramer.|||Nucleus|||Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. http://togogenome.org/gene/9555:ADH5 ^@ http://purl.uniprot.org/uniprot/A0A2I3MN67 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. http://togogenome.org/gene/9555:TXLNA ^@ http://purl.uniprot.org/uniprot/A0A096N233 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/9555:METTL6 ^@ http://purl.uniprot.org/uniprot/A0A096MSL2|||http://purl.uniprot.org/uniprot/A0A2I3MV50 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/9555:CPPED1 ^@ http://purl.uniprot.org/uniprot/A0A096NLS5 ^@ Function|||Similarity ^@ Belongs to the metallophosphoesterase superfamily. CPPED1 family.|||Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes. http://togogenome.org/gene/9555:OOEP ^@ http://purl.uniprot.org/uniprot/A9X185 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ As part of the OOEP-KHDC3 scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart (By similarity). Positively regulates the homologous recombination-mediated DNA double-strand break (DSB) repair pathway by regulating ATM activation and RAD51 recruitment to DSBs in oocytes (By similarity). Thereby contributes to oocyte survival and the resumption and completion of meiosis (By similarity). As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity). Required for the formation of F-actin cytoplasmic lattices in oocytes which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (By similarity).|||Belongs to the KHDC1 family.|||Component of the subcortical maternal complex (SCMC), at least composed of NLRP5, KHDC3, OOEP, and TLE6 (By similarity). Within the complex, interacts with NLRP5, KHDC3 and TLE6 (By similarity). As part of the SCMC interacts with the SCMC-associated protein NLRP4F (By similarity). The SCMC may facilitate translocation of its components between the nuclear and cytoplasmic compartments (By similarity). Forms a scaffold complex with KHDC3/FILIA, and interacts with BLM and TRIM25 at DNA replication forks (By similarity).|||Contains an atypical KH domain with amino acid changes at critical sites, suggesting that it may not bind RNA.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9555:GPX7 ^@ http://purl.uniprot.org/uniprot/A0A096N2H1 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/9555:VWCE ^@ http://purl.uniprot.org/uniprot/A0A096NGZ0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:LPIN2 ^@ http://purl.uniprot.org/uniprot/A0A096N963|||http://purl.uniprot.org/uniprot/A0A2I3LUB8|||http://purl.uniprot.org/uniprot/A0A8I5NA39 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/9555:TTC39B ^@ http://purl.uniprot.org/uniprot/A0A096P1I2|||http://purl.uniprot.org/uniprot/A0A096P1I3 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/9555:EFNA5 ^@ http://purl.uniprot.org/uniprot/A0A096MU88|||http://purl.uniprot.org/uniprot/A0A2I3MB61 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9555:EVX1 ^@ http://purl.uniprot.org/uniprot/A0A096NYN0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:OLFM2 ^@ http://purl.uniprot.org/uniprot/A0A2I3NA02 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/9555:EVA1C ^@ http://purl.uniprot.org/uniprot/A9CAY7 ^@ Similarity ^@ Belongs to the EVA1 family. http://togogenome.org/gene/9555:SHROOM1 ^@ http://purl.uniprot.org/uniprot/A0A096MSB5|||http://purl.uniprot.org/uniprot/A9CB17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shroom family.|||cytoskeleton http://togogenome.org/gene/9555:SNX3 ^@ http://purl.uniprot.org/uniprot/B0CM46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome|||Endosome|||phagosome http://togogenome.org/gene/9555:LOC101010089 ^@ http://purl.uniprot.org/uniprot/A0A8I5NK31 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9555:ATP6V1H ^@ http://purl.uniprot.org/uniprot/A0A096NBF5|||http://purl.uniprot.org/uniprot/A0A2I3M5M0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase H subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9555:GNA13 ^@ http://purl.uniprot.org/uniprot/A0A096NTW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-alpha family. G(12) subfamily.|||Membrane http://togogenome.org/gene/9555:POU1F1 ^@ http://purl.uniprot.org/uniprot/A0A096MTC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/9555:YKT6 ^@ http://purl.uniprot.org/uniprot/A0A8I5NTB0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane|||Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity. http://togogenome.org/gene/9555:NR5A2 ^@ http://purl.uniprot.org/uniprot/A0A096NRJ5|||http://purl.uniprot.org/uniprot/A0A2I3LUG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR5 subfamily.|||Nucleus http://togogenome.org/gene/9555:MIS18A ^@ http://purl.uniprot.org/uniprot/A0A8I5NF40 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.|||centromere http://togogenome.org/gene/9555:LOC101022296 ^@ http://purl.uniprot.org/uniprot/A0A096N9U2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9555:RARG ^@ http://purl.uniprot.org/uniprot/A0A2I3M5T8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9555:ST6GALNAC2 ^@ http://purl.uniprot.org/uniprot/A0A096NT43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9555:BCAS2 ^@ http://purl.uniprot.org/uniprot/A0A096MKK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPF27 family.|||Nucleus http://togogenome.org/gene/9555:CWF19L1 ^@ http://purl.uniprot.org/uniprot/A0A2I3MAQ1 ^@ Similarity ^@ Belongs to the CWF19 family. http://togogenome.org/gene/9555:LOC100999278 ^@ http://purl.uniprot.org/uniprot/A0A8I5NMF1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9555:LOC101017189 ^@ http://purl.uniprot.org/uniprot/A0A096MUS6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9555:LHFPL6 ^@ http://purl.uniprot.org/uniprot/A0A096MQ36 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9555:BORCS5 ^@ http://purl.uniprot.org/uniprot/A0A8I5MZ36|||http://purl.uniprot.org/uniprot/A0A8I5NCA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS5 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9555:VSX2 ^@ http://purl.uniprot.org/uniprot/A0A096NRC0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9555:TMEM14A ^@ http://purl.uniprot.org/uniprot/A0A096NJ55 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/9555:SERF1A ^@ http://purl.uniprot.org/uniprot/A0A2I3MJ79 ^@ Similarity ^@ Belongs to the SERF family. http://togogenome.org/gene/9555:KCNK15 ^@ http://purl.uniprot.org/uniprot/A0A096NX87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9555:FGR ^@ http://purl.uniprot.org/uniprot/A0A2I3LD87 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9555:TLR4 ^@ http://purl.uniprot.org/uniprot/Q9TSP2 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Toll-like receptor family.|||Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binding to bacterial LPS leads to homodimerization. Interacts with LY96 via the extracellular domain. Interacts with MYD88 and TIRAP via their respective TIR domains. Interacts with TICAM2. Interacts with NOX4. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum. Interacts with MAP3K21; this interaction leads to negative regulation of TLR4 signaling. Interacts with CD36, following CD36 stimulation by oxLDL or amyloid-beta 42, and forms a heterodimer with TLR6. The trimeric complex is internalized and triggers inflammatory response. LYN kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Interacts with TICAM1 in response to LPS in a WDFY1-dependent manner. Interacts with WDFY1 in response to LPS. Interacts with SMPDL3B. Interacts with CEACAM1; upon lipopolysaccharide stimulation, forms a complex including TLR4 and the phosphorylated form of SYK and CEACAM1, which in turn, recruits PTPN6 that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome. Interacts with RFTN1; the interaction occurs in response to lipopolysaccharide stimulation. Interacts with SCIMP; the interaction occurs in response to lipopolysaccharide stimulation and is enhanced by phosphorylation of SCIMP by LYN (By similarity). This interaction facilitates the phosphorylation of TLR4 by LYN which elicits a selective cytokine response in macrophages (By similarity). Interacts with TRAF3IP3 (By similarity). Interacts with TREM1; this interaction enhances TLR4-mediated inflammatory response (By similarity).|||Cell membrane|||Early endosome|||In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity.|||Phosphorylated on tyrosine residues by LYN after binding lipopolysaccharide.|||The TIR domain mediates interaction with NOX4.|||Transmembrane receptor that functions as a pattern recognition receptor recognizing pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) to induce innate immune responses via downstream signaling pathways. At the plasma membrane, cooperates with LY96 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Mechanistically, acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Alternatively, CD14-mediated TLR4 internalization via endocytosis is associated with the initiation of a MYD88-independent signaling via the TICAM1-TBK1-IRF3 axis leading to type I interferon production. In addition to the secretion of proinflammatory cytokines, initiates the activation of NLRP3 inflammasome and formation of a positive feedback loop between autophagy and NF-kappa-B signaling cascade. In complex with TLR6, promotes inflammation in monocytes/macrophages by associating with TLR6 and the receptor CD86. Upon ligand binding, such as oxLDL or amyloid-beta 42, the TLR4:TLR6 complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway. In myeloid dendritic cells, vesicular stomatitis virus glycoprotein G but not LPS promotes the activation of IRF7, leading to type I IFN production in a CD14-dependent manner.|||ruffle http://togogenome.org/gene/9555:NDUFAF3 ^@ http://purl.uniprot.org/uniprot/A0A096NQQ1 ^@ Function|||Subcellular Location Annotation ^@ Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).|||Membrane|||Mitochondrion inner membrane|||Nucleus http://togogenome.org/gene/9555:YWHAE ^@ http://purl.uniprot.org/uniprot/A0A096P296 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9555:LOC108587428 ^@ http://purl.uniprot.org/uniprot/A0A2I3N8N4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIIc family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9555:FOLR3 ^@ http://purl.uniprot.org/uniprot/A0A096MUB4 ^@ Similarity ^@ Belongs to the folate receptor family.