http://togogenome.org/gene/9595:RBM15 ^@ http://purl.uniprot.org/uniprot/G3QM63 ^@ Similarity ^@ Belongs to the RRM Spen family. http://togogenome.org/gene/9595:FUNDC2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZER9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FUN14 family.|||Mitochondrion outer membrane http://togogenome.org/gene/9595:CPXM2 ^@ http://purl.uniprot.org/uniprot/G3QW16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||Secreted http://togogenome.org/gene/9595:HIRIP3 ^@ http://purl.uniprot.org/uniprot/G3R8J2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:BGLAP ^@ http://purl.uniprot.org/uniprot/P84349 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the osteocalcin/matrix Gla protein family.|||Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation by GGCX. These residues are essential for the binding of calcium (By similarity). Decarboxylation promotes the hormone activity (By similarity).|||Secreted|||The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein: it acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralization. The carboxylated form binds strongly to apatite and calcium.|||The uncarboxylated form acts as a hormone secreted by osteoblasts, which regulates different cellular processes, such as energy metabolism, male fertility and brain development. Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation, insulin secretion and sensitivity and energy expenditure. Uncarboxylated osteocalcin hormone also promotes testosterone production in the testes: acts as a ligand for G protein-coupled receptor GPRC6A at the surface of Leydig cells, initiating a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner. Also acts as a regulator of brain development: osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons, initiating a signaling response that prevents neuronal apoptosis in the hippocampus, favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development. http://togogenome.org/gene/9595:SLC30A5 ^@ http://purl.uniprot.org/uniprot/G3RGM1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Functions as a zinc transporter.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9595:DHH ^@ http://purl.uniprot.org/uniprot/G3QY79 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the hedgehog family.|||Cell membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane|||Multimer.|||The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.|||The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development. http://togogenome.org/gene/9595:CASP10 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y8W2 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9595:GNB4 ^@ http://purl.uniprot.org/uniprot/G3SB40 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/9595:ADGRG5 ^@ http://purl.uniprot.org/uniprot/G3RE93 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:INO80C ^@ http://purl.uniprot.org/uniprot/G3RZA7|||http://purl.uniprot.org/uniprot/G3SIV1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:LOC101148825 ^@ http://purl.uniprot.org/uniprot/G3SJB3 ^@ Similarity ^@ Belongs to the CTAG/PCC1 family. http://togogenome.org/gene/9595:PAPOLG ^@ http://purl.uniprot.org/uniprot/G3QTE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the poly(A) polymerase family.|||Nucleus http://togogenome.org/gene/9595:PPP4C ^@ http://purl.uniprot.org/uniprot/G3QZX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/9595:SLC16A3 ^@ http://purl.uniprot.org/uniprot/G3QCW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/9595:FAM163A ^@ http://purl.uniprot.org/uniprot/G3QYC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM163 family.|||Membrane http://togogenome.org/gene/9595:TMPRSS11D ^@ http://purl.uniprot.org/uniprot/G3QFY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Membrane http://togogenome.org/gene/9595:NT5E ^@ http://purl.uniprot.org/uniprot/G3QF23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 5'-nucleotidase family.|||Membrane http://togogenome.org/gene/9595:ALG2 ^@ http://purl.uniprot.org/uniprot/G3QNK2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family.|||Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.|||Membrane http://togogenome.org/gene/9595:HTR1D ^@ http://purl.uniprot.org/uniprot/G3QIH0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Homodimer. Heterodimer with HTR1B.|||Membrane http://togogenome.org/gene/9595:EXTL1 ^@ http://purl.uniprot.org/uniprot/G3RJV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:TYSND1 ^@ http://purl.uniprot.org/uniprot/G3RKH0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1B family.|||Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.|||Peroxisome|||The full-lengh TYSND1 is the active the proteolytic processing of PTS1- and PTS2-proteins and in self-cleavage, and intermolecular self-cleavage of TYSND1 down-regulates its protease activity. http://togogenome.org/gene/9595:DACT2 ^@ http://purl.uniprot.org/uniprot/G3RXL6 ^@ Similarity ^@ Belongs to the dapper family. http://togogenome.org/gene/9595:TSC22D3 ^@ http://purl.uniprot.org/uniprot/G3QR51|||http://purl.uniprot.org/uniprot/G3S667 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/9595:HARBI1 ^@ http://purl.uniprot.org/uniprot/G3QP39 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HARBI1 family.|||Cytoplasm|||Nucleus|||Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity. http://togogenome.org/gene/9595:SETD2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1X0 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus http://togogenome.org/gene/9595:SUPT3H ^@ http://purl.uniprot.org/uniprot/G3RFB2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SAP30L ^@ http://purl.uniprot.org/uniprot/G3QP70 ^@ Similarity ^@ Belongs to the SAP30 family. http://togogenome.org/gene/9595:PPP2R5A ^@ http://purl.uniprot.org/uniprot/A0A2I2YD04|||http://purl.uniprot.org/uniprot/G3SAH2 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9595:LOC101129851 ^@ http://purl.uniprot.org/uniprot/G3QHN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. BCS1 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9595:PAPPA2 ^@ http://purl.uniprot.org/uniprot/G3QJM0 ^@ Caution|||Similarity ^@ Belongs to the peptidase M43B family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:LOC101139167 ^@ http://purl.uniprot.org/uniprot/A0A2I2YI12|||http://purl.uniprot.org/uniprot/G3RUW4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C2 family.|||Calcium-regulated non-lysosomal thiol-protease.|||Cytoplasm|||Homodimer.|||nucleolus http://togogenome.org/gene/9595:CTNNB1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZNM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-catenin family.|||adherens junction http://togogenome.org/gene/9595:SLC12A5 ^@ http://purl.uniprot.org/uniprot/G3SBB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9595:BCAT1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YG10|||http://purl.uniprot.org/uniprot/A0A2I2ZT82 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9595:DHTKD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YYP5 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/9595:ADGRG7 ^@ http://purl.uniprot.org/uniprot/G3R5N7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:RAD21 ^@ http://purl.uniprot.org/uniprot/G3R826 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad21 family.|||Nucleus http://togogenome.org/gene/9595:FIGN ^@ http://purl.uniprot.org/uniprot/A0A2I2YB11 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9595:ATP7B ^@ http://purl.uniprot.org/uniprot/G3RTU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9595:PCK1 ^@ http://purl.uniprot.org/uniprot/G3R5Y2 ^@ Similarity|||Subunit ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.|||Monomer. http://togogenome.org/gene/9595:ODF1 ^@ http://purl.uniprot.org/uniprot/G3S8C1 ^@ Function ^@ Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. http://togogenome.org/gene/9595:VTI1B ^@ http://purl.uniprot.org/uniprot/G3S921 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/9595:APOC3 ^@ http://purl.uniprot.org/uniprot/G3QY94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the apolipoprotein C3 family.|||Secreted http://togogenome.org/gene/9595:REEP5 ^@ http://purl.uniprot.org/uniprot/A0A2I2YAD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/9595:SERPINB5 ^@ http://purl.uniprot.org/uniprot/G3RPE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the serpin family. Ov-serpin subfamily.|||extracellular space http://togogenome.org/gene/9595:MON1A ^@ http://purl.uniprot.org/uniprot/A0A2I2YX97|||http://purl.uniprot.org/uniprot/G3R9A5 ^@ Function|||Similarity ^@ Belongs to the MON1/SAND family.|||Plays an important role in membrane trafficking through the secretory apparatus. http://togogenome.org/gene/9595:USP44 ^@ http://purl.uniprot.org/uniprot/G3R033 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9595:CHD8 ^@ http://purl.uniprot.org/uniprot/A0A2I2YBF5|||http://purl.uniprot.org/uniprot/A0A2I2ZB14|||http://purl.uniprot.org/uniprot/A0A2I2ZYX2 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNF2/RAD54 helicase family.|||Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily.|||DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.|||Interacts with p53/TP53, histone H1, CTNNB1, CTCF and PIAS3. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with CHD7. Interacts with FAM124B.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Sumoylated. http://togogenome.org/gene/9595:NMD3 ^@ http://purl.uniprot.org/uniprot/G3RWY0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.|||Belongs to the NMD3 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:DYDC1 ^@ http://purl.uniprot.org/uniprot/G3QJS4|||http://purl.uniprot.org/uniprot/G3RUS7 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/9595:MEIG1 ^@ http://purl.uniprot.org/uniprot/G3RL95 ^@ Function|||Similarity ^@ Belongs to the MEIG1 family.|||Essential for spermiogenesis. http://togogenome.org/gene/9595:LOC101146696 ^@ http://purl.uniprot.org/uniprot/G3QGD7 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9595:CSRNP1 ^@ http://purl.uniprot.org/uniprot/G3RKB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AXUD1 family.|||Nucleus http://togogenome.org/gene/9595:GPC1 ^@ http://purl.uniprot.org/uniprot/G3QGJ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/9595:ACP5 ^@ http://purl.uniprot.org/uniprot/G3R9M5 ^@ Cofactor ^@ Binds 2 iron ions per subunit. http://togogenome.org/gene/9595:RAD18 ^@ http://purl.uniprot.org/uniprot/G3QZ97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAD18 family.|||Nucleus http://togogenome.org/gene/9595:DVL2 ^@ http://purl.uniprot.org/uniprot/G3SDP9 ^@ Similarity ^@ Belongs to the DSH family. http://togogenome.org/gene/9595:PIK3C3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZRM9 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9595:GATA6 ^@ http://purl.uniprot.org/uniprot/G3RZ55 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:RPL39L ^@ http://purl.uniprot.org/uniprot/A0A2I2YLB6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/9595:CSN3 ^@ http://purl.uniprot.org/uniprot/G3QUL0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the kappa-casein family.|||Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.|||Secreted http://togogenome.org/gene/9595:LOC101126098 ^@ http://purl.uniprot.org/uniprot/G3QKC9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9595:RUSF1 ^@ http://purl.uniprot.org/uniprot/G3QP92 ^@ Similarity ^@ Belongs to the RUS1 family. http://togogenome.org/gene/9595:LOC101154255 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZRC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:TMPO ^@ http://purl.uniprot.org/uniprot/A0A2I2YV01|||http://purl.uniprot.org/uniprot/G3QLH5|||http://purl.uniprot.org/uniprot/G3S0I0 ^@ Similarity ^@ Belongs to the LEM family. http://togogenome.org/gene/9595:PLEKHA8 ^@ http://purl.uniprot.org/uniprot/A0A2I2YJM2 ^@ Subcellular Location Annotation ^@ trans-Golgi network membrane http://togogenome.org/gene/9595:PSMD3 ^@ http://purl.uniprot.org/uniprot/G3SF47 ^@ Similarity ^@ Belongs to the proteasome subunit S3 family. http://togogenome.org/gene/9595:NDUFS7 ^@ http://purl.uniprot.org/uniprot/Q0MQH9 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 20 kDa subunit family.|||Binds 1 [4Fe-4S] cluster.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (By similarity). This is a component of the iron-sulfur (IP) fragment of the enzyme (By similarity).|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.|||Hydroxylated ar Arg-111 by NDUFAF5 early in the pathway of assembly of complex I, before the formation of the juncture between peripheral and membrane arms.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:WSCD2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZK03 ^@ Function|||Similarity ^@ Belongs to the WSCD family.|||Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans. http://togogenome.org/gene/9595:EBAG9 ^@ http://purl.uniprot.org/uniprot/G3SGS2 ^@ Function|||Subcellular Location Annotation ^@ Golgi apparatus membrane|||May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. http://togogenome.org/gene/9595:NDUFA12 ^@ http://purl.uniprot.org/uniprot/A0A2I2YU58|||http://purl.uniprot.org/uniprot/Q0MQ86 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA12 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:SLC25A11 ^@ http://purl.uniprot.org/uniprot/G3QDA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9595:POLR2M ^@ http://purl.uniprot.org/uniprot/A0A2I2Y892 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRINL1 family.|||Nucleus http://togogenome.org/gene/9595:ABL2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z7C3|||http://purl.uniprot.org/uniprot/G3QJJ8|||http://purl.uniprot.org/uniprot/G3QJK0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9595:RETN ^@ http://purl.uniprot.org/uniprot/G3R281 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the resistin/FIZZ family.|||Secreted http://togogenome.org/gene/9595:PIM1 ^@ http://purl.uniprot.org/uniprot/G3S2M1 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.|||Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. http://togogenome.org/gene/9595:ELMO3 ^@ http://purl.uniprot.org/uniprot/G3R8E4 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. http://togogenome.org/gene/9595:PKIB ^@ http://purl.uniprot.org/uniprot/A0A2I2Z436|||http://purl.uniprot.org/uniprot/G3RFZ3 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/9595:LPAR2 ^@ http://purl.uniprot.org/uniprot/G3QT70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:GALNT11 ^@ http://purl.uniprot.org/uniprot/G3R0A7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:DEFA6 ^@ http://purl.uniprot.org/uniprot/G3R5P2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-defensin family.|||Secreted http://togogenome.org/gene/9595:GUCY1B1 ^@ http://purl.uniprot.org/uniprot/G3QW61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Cytoplasm http://togogenome.org/gene/9595:PTTG1 ^@ http://purl.uniprot.org/uniprot/G3RL88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the securin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:NMUR2 ^@ http://purl.uniprot.org/uniprot/G3QV11 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for the neuromedin-U and neuromedin-S neuropeptides. http://togogenome.org/gene/9595:ANXA3 ^@ http://purl.uniprot.org/uniprot/G3SEL8 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9595:PKLR ^@ http://purl.uniprot.org/uniprot/G3S6L6 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/9595:VPS4B ^@ http://purl.uniprot.org/uniprot/G3QV21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9595:CTBP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZSE0|||http://purl.uniprot.org/uniprot/G3S0L6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Nucleus http://togogenome.org/gene/9595:CCDC25 ^@ http://purl.uniprot.org/uniprot/G3R2K5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CCDC25 family.|||Cell membrane|||Endomembrane system|||Interacts (via cytoplasmic region) with ILK. http://togogenome.org/gene/9595:GFRAL ^@ http://purl.uniprot.org/uniprot/G3S1J6 ^@ Similarity ^@ Belongs to the GDNFR family. http://togogenome.org/gene/9595:MRPL51 ^@ http://purl.uniprot.org/uniprot/G3RJB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL51 family.|||Mitochondrion http://togogenome.org/gene/9595:LMOD2 ^@ http://purl.uniprot.org/uniprot/G3S961 ^@ Subcellular Location Annotation ^@ cytoskeleton|||sarcomere http://togogenome.org/gene/9595:FGF13 ^@ http://purl.uniprot.org/uniprot/A0A2I2YT95|||http://purl.uniprot.org/uniprot/G3R343|||http://purl.uniprot.org/uniprot/G3RVJ1 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9595:FAM53B ^@ http://purl.uniprot.org/uniprot/G3QH12 ^@ Similarity ^@ Belongs to the FAM53 family. http://togogenome.org/gene/9595:SLC23A2 ^@ http://purl.uniprot.org/uniprot/G3QXX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.|||Membrane http://togogenome.org/gene/9595:NUDT17 ^@ http://purl.uniprot.org/uniprot/G3QWG2 ^@ Function|||Similarity ^@ Belongs to the Nudix hydrolase family.|||Probably mediates the hydrolysis of some nucleoside diphosphate derivatives. http://togogenome.org/gene/9595:NUDT7 ^@ http://purl.uniprot.org/uniprot/A0A2I2YL84|||http://purl.uniprot.org/uniprot/G3RLI6 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. PCD1 subfamily. http://togogenome.org/gene/9595:HTR7 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z5A1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:KIF1C ^@ http://purl.uniprot.org/uniprot/G3R1E6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9595:IAH1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YXY6|||http://purl.uniprot.org/uniprot/G3QHB0 ^@ Function|||Similarity ^@ Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.|||Probable lipase. http://togogenome.org/gene/9595:CPNE3 ^@ http://purl.uniprot.org/uniprot/G3RZC4 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9595:TSPAN6 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z184|||http://purl.uniprot.org/uniprot/G3R3D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9595:RARA ^@ http://purl.uniprot.org/uniprot/A0A2I2Z5W1|||http://purl.uniprot.org/uniprot/A0A2I2ZS07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9595:TMEM50B ^@ http://purl.uniprot.org/uniprot/G3SKJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane http://togogenome.org/gene/9595:MMP16 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y1M9 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9595:TRPV5 ^@ http://purl.uniprot.org/uniprot/G3RIU7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:CCDC103 ^@ http://purl.uniprot.org/uniprot/G3SKG3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CCDC103/PR46b family.|||Cytoplasm|||Dynein-attachment factor required for cilia motility.|||Homodimer.|||flagellum http://togogenome.org/gene/9595:IL6R ^@ http://purl.uniprot.org/uniprot/A0A2I2YXF5|||http://purl.uniprot.org/uniprot/G3QEX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 3 subfamily.|||Membrane http://togogenome.org/gene/9595:MARK3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z9D1|||http://purl.uniprot.org/uniprot/A0A2I2ZM54|||http://purl.uniprot.org/uniprot/G3RNJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||dendrite http://togogenome.org/gene/9595:MAP3K8 ^@ http://purl.uniprot.org/uniprot/G3QS35 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/9595:P4HA1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z3V0|||http://purl.uniprot.org/uniprot/A0A2I2Z806 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9595:GPX7 ^@ http://purl.uniprot.org/uniprot/G3RFD9 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/9595:PPARA ^@ http://purl.uniprot.org/uniprot/A0A2I2Z0P2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.|||Nucleus http://togogenome.org/gene/9595:SPC24 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZIP8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the SPC24 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/9595:SLC7A6OS ^@ http://purl.uniprot.org/uniprot/G3QGS7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IWR1/SLC7A6OS family.|||Cytoplasm|||Directs RNA polymerase II nuclear import.|||Nucleus http://togogenome.org/gene/9595:MMP13 ^@ http://purl.uniprot.org/uniprot/G3QLR7 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9595:SYNE1 ^@ http://purl.uniprot.org/uniprot/G3RG48 ^@ Similarity ^@ Belongs to the nesprin family. http://togogenome.org/gene/9595:LOC101125692 ^@ http://purl.uniprot.org/uniprot/G3RZG3 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9595:FAM151A ^@ http://purl.uniprot.org/uniprot/G3R390 ^@ Similarity ^@ Belongs to the FAM151 family. http://togogenome.org/gene/9595:GAPVD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YB47|||http://purl.uniprot.org/uniprot/A0A2I2YFX9|||http://purl.uniprot.org/uniprot/A0A2I2Z1H9|||http://purl.uniprot.org/uniprot/G3QGT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GAPVD1 family.|||Membrane http://togogenome.org/gene/9595:SLC25A39 ^@ http://purl.uniprot.org/uniprot/A0A2I2YJU3|||http://purl.uniprot.org/uniprot/G3QSS8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:PEX10 ^@ http://purl.uniprot.org/uniprot/G3R4P5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pex2/pex10/pex12 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9595:CRH ^@ http://purl.uniprot.org/uniprot/G3R2F6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Secreted http://togogenome.org/gene/9595:P4HB ^@ http://purl.uniprot.org/uniprot/G3SBE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9595:MPG ^@ http://purl.uniprot.org/uniprot/G3SGM8 ^@ Function|||Similarity ^@ Belongs to the DNA glycosylase MPG family.|||Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions. http://togogenome.org/gene/9595:ADAM17 ^@ http://purl.uniprot.org/uniprot/G3RBF9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:TRIM36 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z3J5|||http://purl.uniprot.org/uniprot/G3RKS5 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9595:MYOD1 ^@ http://purl.uniprot.org/uniprot/G3S3Y5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.|||Nucleus http://togogenome.org/gene/9595:PIGF ^@ http://purl.uniprot.org/uniprot/G3RZI3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:RAB27B ^@ http://purl.uniprot.org/uniprot/G3RHZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/9595:STEEP1 ^@ http://purl.uniprot.org/uniprot/G3RBX9 ^@ Similarity ^@ Belongs to the STEEP1 family. http://togogenome.org/gene/9595:DDX46 ^@ http://purl.uniprot.org/uniprot/A0A2I2YA69 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9595:SRSF1 ^@ http://purl.uniprot.org/uniprot/G3QP16 ^@ Similarity ^@ Belongs to the splicing factor SR family. http://togogenome.org/gene/9595:GET1 ^@ http://purl.uniprot.org/uniprot/G3RBG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WRB/GET1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:BMP10 ^@ http://purl.uniprot.org/uniprot/A0A2I2YG54 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9595:LOC101141704 ^@ http://purl.uniprot.org/uniprot/G3QEJ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:SCT ^@ http://purl.uniprot.org/uniprot/G3RGI1 ^@ Similarity ^@ Belongs to the glucagon family. http://togogenome.org/gene/9595:SCML4 ^@ http://purl.uniprot.org/uniprot/A0A2I2YHA8|||http://purl.uniprot.org/uniprot/G3QV70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCM family.|||Nucleus http://togogenome.org/gene/9595:GLI1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YT57 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/9595:ABCA9 ^@ http://purl.uniprot.org/uniprot/G3RJ50 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:SNX17 ^@ http://purl.uniprot.org/uniprot/G3R5X8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane|||Early endosome|||Endosome|||Membrane http://togogenome.org/gene/9595:NUDT4 ^@ http://purl.uniprot.org/uniprot/G3REH8 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DIPP subfamily. http://togogenome.org/gene/9595:LOC101152880 ^@ http://purl.uniprot.org/uniprot/Q8HY06 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Homotetramer.|||Membrane|||Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates (By similarity).|||The tandem repeat domain, also called neck domain, mediates oligomerization. http://togogenome.org/gene/9595:WDR4 ^@ http://purl.uniprot.org/uniprot/G3RKI4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat TRM82 family.|||Nucleus|||Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. http://togogenome.org/gene/9595:OPRM1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZCV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Endosome|||Membrane|||Perikaryon|||axon|||dendrite http://togogenome.org/gene/9595:KCNMB2 ^@ http://purl.uniprot.org/uniprot/G3RI99 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KCNMB (TC 8.A.14.1) family.|||Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.|||Membrane|||N-glycosylated.|||Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. http://togogenome.org/gene/9595:RALY ^@ http://purl.uniprot.org/uniprot/G3S2S1|||http://purl.uniprot.org/uniprot/G3SGA9 ^@ Similarity ^@ Belongs to the RRM HNRPC family. RALY subfamily. http://togogenome.org/gene/9595:ENO3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y9H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/9595:EIF4A1 ^@ http://purl.uniprot.org/uniprot/G3SGA8 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family. eIF4A subfamily.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9595:LOC109024475 ^@ http://purl.uniprot.org/uniprot/G3RG10 ^@ Similarity|||Subunit ^@ Belongs to the KRTAP type 6 family.|||Interacts with hair keratins. http://togogenome.org/gene/9595:NT5C3B ^@ http://purl.uniprot.org/uniprot/G3R3Q4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrimidine 5'-nucleotidase family.|||Cytoplasm http://togogenome.org/gene/9595:PADI3 ^@ http://purl.uniprot.org/uniprot/G3RGV7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein arginine deiminase family.|||Catalyzes the deimination of arginine residues of proteins.|||Cytoplasm http://togogenome.org/gene/9595:PRF1 ^@ http://purl.uniprot.org/uniprot/G3QHP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Secreted http://togogenome.org/gene/9595:SLC25A34 ^@ http://purl.uniprot.org/uniprot/G3RGQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9595:DNTT ^@ http://purl.uniprot.org/uniprot/G3QFE9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||Nucleus|||Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. http://togogenome.org/gene/9595:PARD6A ^@ http://purl.uniprot.org/uniprot/G3QMR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAR6 family.|||Cytoplasm|||tight junction http://togogenome.org/gene/9595:NTN4 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z326|||http://purl.uniprot.org/uniprot/G3RCW3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:SPDL1 ^@ http://purl.uniprot.org/uniprot/G3QLC1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Spindly family.|||Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect.|||Nucleus|||Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.|||centrosome|||kinetochore|||spindle pole http://togogenome.org/gene/9595:GOLM2 ^@ http://purl.uniprot.org/uniprot/G3SFZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLM family.|||Membrane http://togogenome.org/gene/9595:DEDD2 ^@ http://purl.uniprot.org/uniprot/G3R148 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9595:CA1 ^@ http://purl.uniprot.org/uniprot/Q7M316 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-carbonic anhydrase family.|||Catalyzes the reversible hydration of carbon dioxide. Can hydrate cyanamide to urea.|||Cytoplasm|||Inhibited by acetazolamide. http://togogenome.org/gene/9595:TRDMT1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y2J7 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. http://togogenome.org/gene/9595:GLMP ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1V4|||http://purl.uniprot.org/uniprot/A0A2I2ZIV1|||http://purl.uniprot.org/uniprot/G3REB3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GLMP family.|||Interacts (via lumenal domain) with lysosomal protein MFSD1; the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stability and lysosomal localization of MFSD1.|||Lysosome membrane|||Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization. http://togogenome.org/gene/9595:NDUFB1 ^@ http://purl.uniprot.org/uniprot/G3RNN1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB1 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:MMP3 ^@ http://purl.uniprot.org/uniprot/G3R469 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9595:UPF3A ^@ http://purl.uniprot.org/uniprot/A0A2I2Y5T4|||http://purl.uniprot.org/uniprot/G3SAR2 ^@ Similarity ^@ Belongs to the RENT3 family. http://togogenome.org/gene/9595:EHF ^@ http://purl.uniprot.org/uniprot/A0A2I2YH19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9595:PC ^@ http://purl.uniprot.org/uniprot/G3REY4 ^@ Function ^@ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. http://togogenome.org/gene/9595:MTX3 ^@ http://purl.uniprot.org/uniprot/G3QMU5|||http://purl.uniprot.org/uniprot/G3SFI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metaxin family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9595:STAMBPL1 ^@ http://purl.uniprot.org/uniprot/G3RWC2 ^@ Similarity ^@ Belongs to the peptidase M67C family. http://togogenome.org/gene/9595:APOM ^@ http://purl.uniprot.org/uniprot/G3RRQ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family. Highly divergent.|||Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.|||Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.|||Secreted http://togogenome.org/gene/9595:GALE ^@ http://purl.uniprot.org/uniprot/G3QNX4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family.|||Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.|||Homodimer. http://togogenome.org/gene/9595:RARB ^@ http://purl.uniprot.org/uniprot/G3S8K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9595:CUL4B ^@ http://purl.uniprot.org/uniprot/A0A2I2ZLQ4 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9595:IRF5 ^@ http://purl.uniprot.org/uniprot/A0A2I2YFD3|||http://purl.uniprot.org/uniprot/A0A2I2Z7E3|||http://purl.uniprot.org/uniprot/G3R8K6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:PHYHIPL ^@ http://purl.uniprot.org/uniprot/A0A2I2YUR1|||http://purl.uniprot.org/uniprot/A0A2I2ZQT4|||http://purl.uniprot.org/uniprot/G3R0L3 ^@ Similarity ^@ Belongs to the PHYHIP family. http://togogenome.org/gene/9595:JRK ^@ http://purl.uniprot.org/uniprot/G3RQN3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:RBKS ^@ http://purl.uniprot.org/uniprot/G3R725 ^@ Activity Regulation|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Belongs to the carbohydrate kinase pfkB family.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Nucleus|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/9595:HOXA9 ^@ http://purl.uniprot.org/uniprot/G3QIH8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/9595:KRT74 ^@ http://purl.uniprot.org/uniprot/G3QKU7 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:MCOLN2 ^@ http://purl.uniprot.org/uniprot/G3R915 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9595:CANX ^@ http://purl.uniprot.org/uniprot/G3RX20 ^@ Similarity ^@ Belongs to the calreticulin family. http://togogenome.org/gene/9595:GDF3 ^@ http://purl.uniprot.org/uniprot/G3R9N1 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9595:CTBS ^@ http://purl.uniprot.org/uniprot/G3RI64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 18 family.|||Lysosome http://togogenome.org/gene/9595:SPHKAP ^@ http://purl.uniprot.org/uniprot/G3R5L9 ^@ Similarity ^@ Belongs to the AKAP110 family. http://togogenome.org/gene/9595:SLC25A15 ^@ http://purl.uniprot.org/uniprot/G3S1F4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9595:ZC3HC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z792|||http://purl.uniprot.org/uniprot/G3RHK2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:MEOX2 ^@ http://purl.uniprot.org/uniprot/G3QTT1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:FEV ^@ http://purl.uniprot.org/uniprot/G3R5E2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9595:TMEM123 ^@ http://purl.uniprot.org/uniprot/G3QZ41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD164 family.|||Membrane http://togogenome.org/gene/9595:GGT7 ^@ http://purl.uniprot.org/uniprot/G3RG66 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyltransferase family.|||Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.|||Membrane http://togogenome.org/gene/9595:SNRPG ^@ http://purl.uniprot.org/uniprot/A0A2I2YEA9|||http://purl.uniprot.org/uniprot/A0A2I2Z4Y1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus|||Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.|||cytosol http://togogenome.org/gene/9595:SCNN1G ^@ http://purl.uniprot.org/uniprot/G3QWQ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:ACKR4 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y9C3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:HPSE2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZBM5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 79 family. http://togogenome.org/gene/9595:PPP2R2B ^@ http://purl.uniprot.org/uniprot/A0A2I2YWE8|||http://purl.uniprot.org/uniprot/A0A2I2Z3T1|||http://purl.uniprot.org/uniprot/A0A2I2Z8R0 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/9595:ST6GAL2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z140 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Golgi stack membrane|||Membrane|||Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids. http://togogenome.org/gene/9595:LIPA ^@ http://purl.uniprot.org/uniprot/G3QN03 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9595:ALOX12 ^@ http://purl.uniprot.org/uniprot/G3R2S7 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the lipoxygenase family.|||Binds 1 Fe cation per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:RDH16 ^@ http://purl.uniprot.org/uniprot/G3RKU4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9595:BEX1 ^@ http://purl.uniprot.org/uniprot/G3SBZ1 ^@ Similarity ^@ Belongs to the BEX family. http://togogenome.org/gene/9595:HLCS ^@ http://purl.uniprot.org/uniprot/G3R6B1 ^@ Similarity ^@ Belongs to the biotin--protein ligase family. http://togogenome.org/gene/9595:LCK ^@ http://purl.uniprot.org/uniprot/G3QJD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/9595:RIC3 ^@ http://purl.uniprot.org/uniprot/G3QME0 ^@ Similarity ^@ Belongs to the ric-3 family. http://togogenome.org/gene/9595:KCNS2 ^@ http://purl.uniprot.org/uniprot/G3QJZ2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:STK32B ^@ http://purl.uniprot.org/uniprot/G3R3J6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:KLC4 ^@ http://purl.uniprot.org/uniprot/G3R4U2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kinesin light chain family.|||Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.|||Oligomeric complex composed of two heavy chains and two light chains.|||cytoskeleton http://togogenome.org/gene/9595:CPOX ^@ http://purl.uniprot.org/uniprot/G3REH3 ^@ Similarity|||Subunit ^@ Belongs to the aerobic coproporphyrinogen-III oxidase family.|||Homodimer. http://togogenome.org/gene/9595:NAPSA ^@ http://purl.uniprot.org/uniprot/G3QK89 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/9595:SIM2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y3I5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SUGP1 ^@ http://purl.uniprot.org/uniprot/G3QKG2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:ZMYND10 ^@ http://purl.uniprot.org/uniprot/G3QW15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the ZMYND10 family.|||Dynein axonemal particle|||Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.|||centriolar satellite http://togogenome.org/gene/9595:KPNA6 ^@ http://purl.uniprot.org/uniprot/A0A2I2YR04 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9595:RANBP10 ^@ http://purl.uniprot.org/uniprot/G3RLS8 ^@ Similarity ^@ Belongs to the RANBP9/10 family. http://togogenome.org/gene/9595:PPP1R1C ^@ http://purl.uniprot.org/uniprot/G3SHT3 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 1 family. http://togogenome.org/gene/9595:CPEB4 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y9G1|||http://purl.uniprot.org/uniprot/A0A2I2Z0N7|||http://purl.uniprot.org/uniprot/A0A2I2Z1M3|||http://purl.uniprot.org/uniprot/G3R3M7 ^@ Similarity ^@ Belongs to the RRM CPEB family. http://togogenome.org/gene/9595:UHRF1 ^@ http://purl.uniprot.org/uniprot/G3RVG5 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications.|||Nucleus|||The YDG domain mediates the interaction with histone H3.|||The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3). http://togogenome.org/gene/9595:NFXL1 ^@ http://purl.uniprot.org/uniprot/G3QZI7 ^@ Similarity ^@ Belongs to the NFX1 family. http://togogenome.org/gene/9595:LOC101130783 ^@ http://purl.uniprot.org/uniprot/G3QM00 ^@ Similarity ^@ Belongs to the TCAF family. http://togogenome.org/gene/9595:MDM4 ^@ http://purl.uniprot.org/uniprot/G3RB06 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM2/MDM4 family.|||Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.|||Nucleus http://togogenome.org/gene/9595:PAX6 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZFV9|||http://purl.uniprot.org/uniprot/G3RQQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/9595:FAM167A ^@ http://purl.uniprot.org/uniprot/G3RJ13 ^@ Similarity ^@ Belongs to the FAM167 (SEC) family. http://togogenome.org/gene/9595:LOC101152116 ^@ http://purl.uniprot.org/uniprot/G3RF92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ITGA2 ^@ http://purl.uniprot.org/uniprot/G3QG21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9595:RECQL ^@ http://purl.uniprot.org/uniprot/A0A2I2ZF50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RecQ subfamily.|||Nucleus http://togogenome.org/gene/9595:ADGRV1 ^@ http://purl.uniprot.org/uniprot/G3R5Z0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:WARS2 ^@ http://purl.uniprot.org/uniprot/G3RGC4|||http://purl.uniprot.org/uniprot/G3RVR3 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9595:TMEM41B ^@ http://purl.uniprot.org/uniprot/A0A2I2YMS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM41 family.|||Membrane http://togogenome.org/gene/9595:ELF3 ^@ http://purl.uniprot.org/uniprot/G3RE61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9595:VPS72 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZUZ9 ^@ Function|||Similarity ^@ Belongs to the VPS72/YL1 family.|||Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. http://togogenome.org/gene/9595:CXCL13 ^@ http://purl.uniprot.org/uniprot/G3RE10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9595:MAN1C1 ^@ http://purl.uniprot.org/uniprot/G3R750 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9595:DLK1 ^@ http://purl.uniprot.org/uniprot/G3QDU0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:PNPT1 ^@ http://purl.uniprot.org/uniprot/G3QVF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the polyribonucleotide nucleotidyltransferase family.|||Cytoplasm http://togogenome.org/gene/9595:PTCD2 ^@ http://purl.uniprot.org/uniprot/G3R562 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTCD2 family.|||Mitochondrion http://togogenome.org/gene/9595:NPTXR ^@ http://purl.uniprot.org/uniprot/G3SD80 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:MAP2K1 ^@ http://purl.uniprot.org/uniprot/G3QM92 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:LAMB2 ^@ http://purl.uniprot.org/uniprot/G3RG19 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/9595:AQP6 ^@ http://purl.uniprot.org/uniprot/G3QSX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9595:CD53 ^@ http://purl.uniprot.org/uniprot/G3QRU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9595:ATR ^@ http://purl.uniprot.org/uniprot/A0A2I2YTG6 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. ATM subfamily. http://togogenome.org/gene/9595:FAM83B ^@ http://purl.uniprot.org/uniprot/G3QIH2 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9595:GJA5 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZC67 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9595:UCP3 ^@ http://purl.uniprot.org/uniprot/G3QDL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9595:MCM6 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZI12 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/9595:PRIM1 ^@ http://purl.uniprot.org/uniprot/G3RCL3 ^@ Similarity ^@ Belongs to the eukaryotic-type primase small subunit family. http://togogenome.org/gene/9595:PPP1R13B ^@ http://purl.uniprot.org/uniprot/G3SBW5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:MFSD14A ^@ http://purl.uniprot.org/uniprot/G3QF32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/9595:ICAM5 ^@ http://purl.uniprot.org/uniprot/G3QT56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. ICAM family.|||Membrane http://togogenome.org/gene/9595:CRAT ^@ http://purl.uniprot.org/uniprot/G3RRT6 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/9595:GFM1 ^@ http://purl.uniprot.org/uniprot/G3QKQ5|||http://purl.uniprot.org/uniprot/G3S1S5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.|||Mitochondrion http://togogenome.org/gene/9595:VAX2 ^@ http://purl.uniprot.org/uniprot/G3QWH6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:POU1F1 ^@ http://purl.uniprot.org/uniprot/G3R8G0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/9595:SNRPE ^@ http://purl.uniprot.org/uniprot/A0A2I2ZKR4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing.|||cytosol http://togogenome.org/gene/9595:IGF1R ^@ http://purl.uniprot.org/uniprot/G3RAQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Membrane http://togogenome.org/gene/9595:LOC101141650 ^@ http://purl.uniprot.org/uniprot/G3R102 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase IV family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9595:CDH18 ^@ http://purl.uniprot.org/uniprot/G3R5X3 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:HARS1 ^@ http://purl.uniprot.org/uniprot/G3RBJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/9595:LOC101134144 ^@ http://purl.uniprot.org/uniprot/G3QFX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYT1 family.|||Nucleus http://togogenome.org/gene/9595:MOCS2 ^@ http://purl.uniprot.org/uniprot/G3QG23 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MoaE family. MOCS2B subfamily.|||Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.|||Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.|||This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame.|||cytosol http://togogenome.org/gene/9595:HNF4A ^@ http://purl.uniprot.org/uniprot/G3QVQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9595:GALNT3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZSP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:SEPTIN6 ^@ http://purl.uniprot.org/uniprot/A0A2I2YF25|||http://purl.uniprot.org/uniprot/A0A2I2YIA9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9595:IL1F10 ^@ http://purl.uniprot.org/uniprot/G3R1W6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9595:LOC101137477 ^@ http://purl.uniprot.org/uniprot/G3RZV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:TBP ^@ http://purl.uniprot.org/uniprot/G3R850 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBP family.|||Nucleus http://togogenome.org/gene/9595:SFXN2 ^@ http://purl.uniprot.org/uniprot/G3R1U1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9595:GNG13 ^@ http://purl.uniprot.org/uniprot/A0A2I2YWI6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9595:ETV7 ^@ http://purl.uniprot.org/uniprot/A0A2I2YSH2|||http://purl.uniprot.org/uniprot/G3RPE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9595:OTX2 ^@ http://purl.uniprot.org/uniprot/G3QN58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9595:NOS2 ^@ http://purl.uniprot.org/uniprot/G3RR01 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NOS family.|||Binds 1 FAD.|||Binds 1 FMN.|||Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. http://togogenome.org/gene/9595:DNTTIP2 ^@ http://purl.uniprot.org/uniprot/G3RRP0 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9595:RFC1 ^@ http://purl.uniprot.org/uniprot/G3RXK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the activator 1 large subunit family.|||Nucleus http://togogenome.org/gene/9595:LOC109023730 ^@ http://purl.uniprot.org/uniprot/G3RSH0 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9595:CHRNA2 ^@ http://purl.uniprot.org/uniprot/G3RHT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9595:LAGE3 ^@ http://purl.uniprot.org/uniprot/G3RCE7 ^@ Similarity ^@ Belongs to the CTAG/PCC1 family. http://togogenome.org/gene/9595:ZFP36 ^@ http://purl.uniprot.org/uniprot/G3REP8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.|||Cytoplasm|||Nucleus|||Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. http://togogenome.org/gene/9595:CZIB ^@ http://purl.uniprot.org/uniprot/G3QN47 ^@ Similarity ^@ Belongs to the UPF0587 family. http://togogenome.org/gene/9595:PRPSAP1 ^@ http://purl.uniprot.org/uniprot/G3SKM1 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/9595:REEP3 ^@ http://purl.uniprot.org/uniprot/G3RNL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/9595:DTD1 ^@ http://purl.uniprot.org/uniprot/G3QCX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DTD family.|||Cytoplasm http://togogenome.org/gene/9595:FKRP ^@ http://purl.uniprot.org/uniprot/A0A2I2ZR51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LicD transferase family.|||Golgi apparatus membrane http://togogenome.org/gene/9595:CAMP ^@ http://purl.uniprot.org/uniprot/A0A2K5TIY0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cathelicidin family.|||Exhibits antimicrobial activity against E.coli and B.megaterium (in vitro).|||Secreted|||Vesicle http://togogenome.org/gene/9595:CD244 ^@ http://purl.uniprot.org/uniprot/G3QS67 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:PIH1D1 ^@ http://purl.uniprot.org/uniprot/G3RU31 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/9595:YJU2B ^@ http://purl.uniprot.org/uniprot/G3QUS3 ^@ Similarity ^@ Belongs to the CWC16 family. http://togogenome.org/gene/9595:PFKM ^@ http://purl.uniprot.org/uniprot/G3QUC7 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homo- and heterotetramers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:BTN2A2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZXA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Membrane http://togogenome.org/gene/9595:BANF2 ^@ http://purl.uniprot.org/uniprot/G3QQ95 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:HNMT ^@ http://purl.uniprot.org/uniprot/G3R7E5 ^@ Function|||Subunit ^@ Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.|||Monomer. http://togogenome.org/gene/9595:DLX3 ^@ http://purl.uniprot.org/uniprot/G3RG95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus http://togogenome.org/gene/9595:KIF17 ^@ http://purl.uniprot.org/uniprot/G3RF78 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9595:COPS8 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZLE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN8 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:SH3GLB1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YIS4|||http://purl.uniprot.org/uniprot/A0A2I2YMI0|||http://purl.uniprot.org/uniprot/A0A2I2Z1Q5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Golgi apparatus membrane|||Midbody|||Mitochondrion outer membrane|||autophagosome membrane http://togogenome.org/gene/9595:TNFAIP3 ^@ http://purl.uniprot.org/uniprot/G3QLD1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9595:TMEM14B ^@ http://purl.uniprot.org/uniprot/A0A2I2Y4V8|||http://purl.uniprot.org/uniprot/A0A2I2ZCS9 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/9595:RAP2B ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1X2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Palmitoylated.|||Recycling endosome membrane|||Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. http://togogenome.org/gene/9595:PRKACB ^@ http://purl.uniprot.org/uniprot/A0A2I2Z6Y0|||http://purl.uniprot.org/uniprot/A0A2I2ZBE7|||http://purl.uniprot.org/uniprot/A0A2I2ZC53|||http://purl.uniprot.org/uniprot/A0A2I2ZDX1|||http://purl.uniprot.org/uniprot/G3SC72 ^@ Similarity ^@ Belongs to the protein kinase superfamily.|||Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/9595:CCNT2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YB05|||http://purl.uniprot.org/uniprot/A0A2I2YFM0 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9595:CCNC ^@ http://purl.uniprot.org/uniprot/A0A2I2YSZ3|||http://purl.uniprot.org/uniprot/G3QWU6 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9595:SHROOM2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y6Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shroom family.|||cytoskeleton http://togogenome.org/gene/9595:GATAD2A ^@ http://purl.uniprot.org/uniprot/G3S585 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:PPP5C ^@ http://purl.uniprot.org/uniprot/G3QX73 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily. http://togogenome.org/gene/9595:TSR1 ^@ http://purl.uniprot.org/uniprot/G3QH58 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9595:TUBE1 ^@ http://purl.uniprot.org/uniprot/G3QQD6 ^@ Similarity ^@ Belongs to the tubulin family. http://togogenome.org/gene/9595:CD40LG ^@ http://purl.uniprot.org/uniprot/A0A2I2YT93 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.|||Belongs to the tumor necrosis factor family.|||Cell surface|||Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.|||Homotrimer. http://togogenome.org/gene/9595:COPE ^@ http://purl.uniprot.org/uniprot/G3QVQ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPE family.|||Cytoplasm|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. http://togogenome.org/gene/9595:IRX1 ^@ http://purl.uniprot.org/uniprot/G3SJC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/IRO homeobox family.|||Nucleus http://togogenome.org/gene/9595:DLGAP5 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZGM2|||http://purl.uniprot.org/uniprot/G3QLP8 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/9595:SOAT2 ^@ http://purl.uniprot.org/uniprot/G3QKW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:NNT ^@ http://purl.uniprot.org/uniprot/G3QRV0 ^@ Similarity ^@ In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/9595:USP48 ^@ http://purl.uniprot.org/uniprot/G3RU24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Nucleus http://togogenome.org/gene/9595:PSMB2 ^@ http://purl.uniprot.org/uniprot/G3SJ48 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:CHRNG ^@ http://purl.uniprot.org/uniprot/G3QI66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9595:DDX52 ^@ http://purl.uniprot.org/uniprot/G3S4T6 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily. http://togogenome.org/gene/9595:NACC1 ^@ http://purl.uniprot.org/uniprot/G3SJX3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:TMEM94 ^@ http://purl.uniprot.org/uniprot/G3RUP2|||http://purl.uniprot.org/uniprot/G3SCJ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:TMC3 ^@ http://purl.uniprot.org/uniprot/G3QR19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMC family.|||Membrane http://togogenome.org/gene/9595:HTATIP2 ^@ http://purl.uniprot.org/uniprot/A1YER2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Monomer. Binds nuclear transport receptors XPO4, IPO5/RANBP5, IPO7, IPO9 and KPNB1 as well as GCN1L1/GCN1 and LRPPRC probably through their HEAT repeats. Binds NCOA5/CIA (By similarity).|||Nucleus envelope|||Oxidoreductase required for tumor suppression. NADPH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import (By similarity). http://togogenome.org/gene/9595:PDCL2 ^@ http://purl.uniprot.org/uniprot/G3QY16 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9595:SOX21 ^@ http://purl.uniprot.org/uniprot/G3RV32 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:PANX3 ^@ http://purl.uniprot.org/uniprot/G3QMD9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Structural component of the gap junctions and the hemichannels.|||gap junction http://togogenome.org/gene/9595:DDX41 ^@ http://purl.uniprot.org/uniprot/G3REY5 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX41 subfamily. http://togogenome.org/gene/9595:ERF ^@ http://purl.uniprot.org/uniprot/G3QPR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9595:SMIM15 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y3E7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM15 family.|||Membrane http://togogenome.org/gene/9595:POLG2 ^@ http://purl.uniprot.org/uniprot/G3RHB8 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9595:NR0B1 ^@ http://purl.uniprot.org/uniprot/G3QIY2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR0 subfamily.|||Cytoplasm|||Nucleus|||Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency. http://togogenome.org/gene/9595:XPO7 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z687 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:CD22 ^@ http://purl.uniprot.org/uniprot/Q9N1E4 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.|||Cell membrane|||Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.|||Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling cascade key molecules.|||Phosphorylated on tyrosine residues by LYN.|||Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively. Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2.|||Predominantly monomer of isoform CD22-beta. Also found as heterodimer of isoform CD22-beta and a shorter isoform. Interacts with PTPN6/SHP-1, LYN, SYK, PIK3R1/PIK3R2 and PLCG1 upon phosphorylation. Interacts with GRB2, INPP5D and SHC1 upon phosphorylation (By similarity). May form a complex with INPP5D/SHIP, GRB2 and SHC1 (By similarity). http://togogenome.org/gene/9595:ATP7A ^@ http://purl.uniprot.org/uniprot/G3S1J0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9595:ECSIT ^@ http://purl.uniprot.org/uniprot/A0A2I2YBD8|||http://purl.uniprot.org/uniprot/A0A2I2YNV3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.|||Belongs to the ECSIT family.|||Cytoplasm|||Mitochondrion|||Nucleus http://togogenome.org/gene/9595:MRTO4 ^@ http://purl.uniprot.org/uniprot/G3QE40 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the pre-60S ribosomal particle.|||Belongs to the universal ribosomal protein uL10 family.|||Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.|||Cytoplasm|||nucleolus http://togogenome.org/gene/9595:NUP35 ^@ http://purl.uniprot.org/uniprot/G3R368 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Nup35 family.|||Functions as a component of the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/9595:LOC101151732 ^@ http://purl.uniprot.org/uniprot/Q6LDH0 ^@ Function|||Similarity|||Subunit|||Tissue Specificity ^@ Belongs to the globin family.|||Heterotetramer of two alpha chains and two epsilon chains in early embryonic hemoglobin Gower-2; two zeta chains and two epsilon chains in early embryonic hemoglobin Gower-1.|||Red blood cells.|||The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin. http://togogenome.org/gene/9595:ARMC10 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZST0|||http://purl.uniprot.org/uniprot/G3QH76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eutherian X-chromosome-specific Armcx family.|||Membrane http://togogenome.org/gene/9595:LOC101137637 ^@ http://purl.uniprot.org/uniprot/G3RF00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:CENPB ^@ http://purl.uniprot.org/uniprot/A0A2I2ZG27 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:NAPG ^@ http://purl.uniprot.org/uniprot/G3RHC2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/9595:DNAL4 ^@ http://purl.uniprot.org/uniprot/G3RCG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/9595:RUNX1T1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y379|||http://purl.uniprot.org/uniprot/A0A2I2ZGA4|||http://purl.uniprot.org/uniprot/A0A2I2ZQG2 ^@ Similarity ^@ Belongs to the CBFA2T family. http://togogenome.org/gene/9595:KRT13 ^@ http://purl.uniprot.org/uniprot/G3RL36 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:PTPN2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y272|||http://purl.uniprot.org/uniprot/G3RMA5 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. http://togogenome.org/gene/9595:KIF21A ^@ http://purl.uniprot.org/uniprot/A0A2I2YP88|||http://purl.uniprot.org/uniprot/G3RU75 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9595:RAB3IP ^@ http://purl.uniprot.org/uniprot/G3QZA3|||http://purl.uniprot.org/uniprot/G3RR29 ^@ Similarity ^@ Belongs to the SEC2 family. http://togogenome.org/gene/9595:CAMK1G ^@ http://purl.uniprot.org/uniprot/G3QFX0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:DBT ^@ http://purl.uniprot.org/uniprot/G3S1Q1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Mitochondrion matrix http://togogenome.org/gene/9595:SET ^@ http://purl.uniprot.org/uniprot/G3S4E1 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9595:NELFCD ^@ http://purl.uniprot.org/uniprot/G3QV15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NELF-D family.|||Nucleus http://togogenome.org/gene/9595:NCK2 ^@ http://purl.uniprot.org/uniprot/G3RFN5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Endoplasmic reticulum http://togogenome.org/gene/9595:FAM174C ^@ http://purl.uniprot.org/uniprot/G3S6U4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM174 family.|||Membrane http://togogenome.org/gene/9595:RNASE7 ^@ http://purl.uniprot.org/uniprot/A0A2I2YVV3 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9595:DDRGK1 ^@ http://purl.uniprot.org/uniprot/G3R061 ^@ Similarity ^@ Belongs to the DDRGK1 family. http://togogenome.org/gene/9595:PSMD1 ^@ http://purl.uniprot.org/uniprot/G3RVS1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S1 family.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. http://togogenome.org/gene/9595:GIMAP4 ^@ http://purl.uniprot.org/uniprot/G3QIU6 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9595:FAM24B ^@ http://purl.uniprot.org/uniprot/G3QW84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM24 family.|||Secreted http://togogenome.org/gene/9595:LOC101143893 ^@ http://purl.uniprot.org/uniprot/G3QJG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine gamma family.|||Secreted http://togogenome.org/gene/9595:NRXN2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y2T6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:TIE1 ^@ http://purl.uniprot.org/uniprot/G3R075 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:SLC14A2 ^@ http://purl.uniprot.org/uniprot/G3QFG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urea transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:PNPO ^@ http://purl.uniprot.org/uniprot/A0A2I2YWE4 ^@ Function|||Similarity ^@ Belongs to the pyridoxamine 5'-phosphate oxidase family.|||Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). http://togogenome.org/gene/9595:PIGU ^@ http://purl.uniprot.org/uniprot/G3QU94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGU family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:SLC35F4 ^@ http://purl.uniprot.org/uniprot/A0A2I2YY71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/9595:LDLRAD3 ^@ http://purl.uniprot.org/uniprot/G3RKF8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:ANAPC2 ^@ http://purl.uniprot.org/uniprot/G3RV64 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9595:GRHL2 ^@ http://purl.uniprot.org/uniprot/G3SG69 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SST ^@ http://purl.uniprot.org/uniprot/G3S1J4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatostatin family.|||Secreted http://togogenome.org/gene/9595:MED28 ^@ http://purl.uniprot.org/uniprot/G3QFM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 28 family.|||Nucleus http://togogenome.org/gene/9595:BLOC1S1 ^@ http://purl.uniprot.org/uniprot/G3QKX5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BLOC1S1 family.|||Lysosome membrane|||May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9.|||Mitochondrion intermembrane space http://togogenome.org/gene/9595:NOSTRIN ^@ http://purl.uniprot.org/uniprot/G3RPD3 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9595:ERLIN1 ^@ http://purl.uniprot.org/uniprot/G3R4T9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the band 7/mec-2 family.|||Endoplasmic reticulum membrane|||Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.|||Membrane http://togogenome.org/gene/9595:ATP6AP2 ^@ http://purl.uniprot.org/uniprot/G3S9T4 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Lysosome membrane|||Membrane|||autophagosome membrane|||clathrin-coated vesicle membrane|||dendritic spine membrane|||synaptic vesicle membrane http://togogenome.org/gene/9595:ABHD2 ^@ http://purl.uniprot.org/uniprot/G3R7Q2 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/9595:ATP1A3 ^@ http://purl.uniprot.org/uniprot/G3QT34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:TPPP3 ^@ http://purl.uniprot.org/uniprot/G3QZH6 ^@ Similarity ^@ Belongs to the TPPP family. http://togogenome.org/gene/9595:PIP ^@ http://purl.uniprot.org/uniprot/A0A885 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PIP family.|||Monomer. Interacts with AZGP1 (By similarity).|||Secreted http://togogenome.org/gene/9595:UCK2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YXB8 ^@ Similarity ^@ Belongs to the uridine kinase family. http://togogenome.org/gene/9595:GSK3B ^@ http://purl.uniprot.org/uniprot/A0A2I2Y1S1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. http://togogenome.org/gene/9595:BEST3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YBH8|||http://purl.uniprot.org/uniprot/A0A2I2ZK62|||http://purl.uniprot.org/uniprot/G3R1I6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms calcium-sensitive chloride channels. Permeable to bicarbonate.|||Membrane http://togogenome.org/gene/9595:SLC16A11 ^@ http://purl.uniprot.org/uniprot/G3QG12 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:NIPAL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YE80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9595:QRSL1 ^@ http://purl.uniprot.org/uniprot/G3SBQ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/9595:LOC101128369 ^@ http://purl.uniprot.org/uniprot/G3QFB1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat HIR1 family.|||Nucleus|||Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle. http://togogenome.org/gene/9595:NDST1 ^@ http://purl.uniprot.org/uniprot/G3RCY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/9595:FUCA1 ^@ http://purl.uniprot.org/uniprot/G3QV26 ^@ Function|||Similarity|||Subunit ^@ Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.|||Belongs to the glycosyl hydrolase 29 family.|||Homotetramer. http://togogenome.org/gene/9595:CXCL11 ^@ http://purl.uniprot.org/uniprot/A0A2I2YQQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9595:INTS3 ^@ http://purl.uniprot.org/uniprot/G3RTH1 ^@ Similarity ^@ Belongs to the Integrator subunit 3 family. http://togogenome.org/gene/9595:PTPN6 ^@ http://purl.uniprot.org/uniprot/G3QNS0|||http://purl.uniprot.org/uniprot/G3RE40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.|||Cytoplasm http://togogenome.org/gene/9595:FLT1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZNE7|||http://purl.uniprot.org/uniprot/G3SHN4 ^@ Subunit ^@ Forms a complex composed of PDGFRL, TNK2 and GRB2. http://togogenome.org/gene/9595:DUSP1 ^@ http://purl.uniprot.org/uniprot/G3QW32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/9595:RAB3IL1 ^@ http://purl.uniprot.org/uniprot/G3RMA9 ^@ Similarity ^@ Belongs to the SEC2 family. http://togogenome.org/gene/9595:HBQ1 ^@ http://purl.uniprot.org/uniprot/G3RJU5 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9595:SLIT2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z9V9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9595:GABRG1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZBY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9595:ALKBH6 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZG06|||http://purl.uniprot.org/uniprot/A0A2I2ZR67 ^@ Similarity ^@ Belongs to the alkB family. http://togogenome.org/gene/9595:SHTN1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YTM9|||http://purl.uniprot.org/uniprot/G3SI42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shootin family.|||Perikaryon|||axon|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/9595:GOLM1 ^@ http://purl.uniprot.org/uniprot/G3R9T4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLM family.|||Membrane http://togogenome.org/gene/9595:PFKFB4 ^@ http://purl.uniprot.org/uniprot/G3R5N0 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/9595:AP5M1 ^@ http://purl.uniprot.org/uniprot/G3QSF9 ^@ Subcellular Location Annotation|||Subunit ^@ Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane|||Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1. http://togogenome.org/gene/9595:NPFFR2 ^@ http://purl.uniprot.org/uniprot/G3R6B9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9595:LOC101129773 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZQM8|||http://purl.uniprot.org/uniprot/G3QXG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.|||Membrane http://togogenome.org/gene/9595:NDUFV1 ^@ http://purl.uniprot.org/uniprot/Q0MQI5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 51 kDa subunit family.|||Binds 1 FMN.|||Binds 1 [4Fe-4S] cluster.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (By similarity). This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme (By similarity). Interacts with RAB5IF (By similarity).|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:ACTR10 ^@ http://purl.uniprot.org/uniprot/G3QVF4 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9595:LMNA ^@ http://purl.uniprot.org/uniprot/G3QEU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intermediate filament family.|||Nucleus lamina http://togogenome.org/gene/9595:COQ10A ^@ http://purl.uniprot.org/uniprot/G3R133|||http://purl.uniprot.org/uniprot/G3S4I7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the COQ10 family.|||Interacts with coenzyme Q.|||Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. http://togogenome.org/gene/9595:HMGCS1 ^@ http://purl.uniprot.org/uniprot/G3QFP6 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family.|||Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. http://togogenome.org/gene/9595:TBX3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YWL2|||http://purl.uniprot.org/uniprot/G3QNP1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9595:CDC14A ^@ http://purl.uniprot.org/uniprot/A0A2I2YAS9|||http://purl.uniprot.org/uniprot/A0A2I2Z2L9|||http://purl.uniprot.org/uniprot/A0A2I2Z754 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily. http://togogenome.org/gene/9595:SERPING1 ^@ http://purl.uniprot.org/uniprot/G3RHZ3 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9595:LPIN2 ^@ http://purl.uniprot.org/uniprot/G3QDK3 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/9595:IPO13 ^@ http://purl.uniprot.org/uniprot/G3RJT7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the importin beta family.|||Cytoplasm|||Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.|||Nucleus http://togogenome.org/gene/9595:KBTBD8 ^@ http://purl.uniprot.org/uniprot/G3RYR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KBTBD8 family.|||Golgi apparatus|||spindle http://togogenome.org/gene/9595:RIOX2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z0X2|||http://purl.uniprot.org/uniprot/G3RJE4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ROX family. MINA53 subfamily.|||Binds 1 Fe(2+) ion per subunit.|||Nucleus|||Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. http://togogenome.org/gene/9595:LOC101151536 ^@ http://purl.uniprot.org/uniprot/G3R3H9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase IV family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9595:SLC4A10 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZDH3|||http://purl.uniprot.org/uniprot/G3S614 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9595:CCL23 ^@ http://purl.uniprot.org/uniprot/G3QLY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9595:TMEM86B ^@ http://purl.uniprot.org/uniprot/G3QRI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM86 family.|||Membrane http://togogenome.org/gene/9595:ARPIN ^@ http://purl.uniprot.org/uniprot/A0A2I2ZMV0 ^@ Similarity ^@ Belongs to the Arpin family. http://togogenome.org/gene/9595:ABCC3 ^@ http://purl.uniprot.org/uniprot/G3QLJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:FGFBP2 ^@ http://purl.uniprot.org/uniprot/G3S6Y9 ^@ Similarity ^@ Belongs to the fibroblast growth factor-binding protein family. http://togogenome.org/gene/9595:LOC101142758 ^@ http://purl.uniprot.org/uniprot/G3QK98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||Endoplasmic reticulum http://togogenome.org/gene/9595:SNX13 ^@ http://purl.uniprot.org/uniprot/A0A2I2YC30 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9595:EIF2B2 ^@ http://purl.uniprot.org/uniprot/G3QE21 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/9595:LOC101140761 ^@ http://purl.uniprot.org/uniprot/G3SFL0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9595:PMEL ^@ http://purl.uniprot.org/uniprot/G3RDU4 ^@ Similarity ^@ Belongs to the PMEL/NMB family. http://togogenome.org/gene/9595:DDX54 ^@ http://purl.uniprot.org/uniprot/G3R4G8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.|||nucleolus http://togogenome.org/gene/9595:CPPED1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y3C8 ^@ Function|||Similarity ^@ Belongs to the metallophosphoesterase superfamily. CPPED1 family.|||Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes. http://togogenome.org/gene/9595:FHL5 ^@ http://purl.uniprot.org/uniprot/G3QNM5 ^@ Function|||Subcellular Location Annotation ^@ May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.|||Nucleus http://togogenome.org/gene/9595:SPTBN1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZWA3 ^@ Similarity ^@ Belongs to the spectrin family. http://togogenome.org/gene/9595:COQ4 ^@ http://purl.uniprot.org/uniprot/G3RFQ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ4 family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:FMNL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YLV3 ^@ Similarity ^@ Belongs to the formin homology family. http://togogenome.org/gene/9595:ERCC4 ^@ http://purl.uniprot.org/uniprot/G3REB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPF family.|||Nucleus http://togogenome.org/gene/9595:SGMS2 ^@ http://purl.uniprot.org/uniprot/G3RA31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/9595:LOC101134469 ^@ http://purl.uniprot.org/uniprot/G3RXT8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9595:GDF10 ^@ http://purl.uniprot.org/uniprot/G3QSX3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer.|||Secreted http://togogenome.org/gene/9595:VPS37B ^@ http://purl.uniprot.org/uniprot/G3QQI9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9595:KRT15 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z0J1 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:ATP6V1B1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YJ09 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits. http://togogenome.org/gene/9595:PARP9 ^@ http://purl.uniprot.org/uniprot/G3RIR3 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9595:FOXN1 ^@ http://purl.uniprot.org/uniprot/G3R2K4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SSRP1 ^@ http://purl.uniprot.org/uniprot/G3R9I5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SSRP1 family.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Nucleus http://togogenome.org/gene/9595:QNG1 ^@ http://purl.uniprot.org/uniprot/G3R6P5 ^@ Function|||Similarity ^@ Belongs to the QNG1 protein family.|||Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly. http://togogenome.org/gene/9595:STC2 ^@ http://purl.uniprot.org/uniprot/G3RD02 ^@ Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9595:SH3BGRL2 ^@ http://purl.uniprot.org/uniprot/G3RR85 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/9595:ARHGEF3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZAZ4|||http://purl.uniprot.org/uniprot/A0A2I2ZTX9|||http://purl.uniprot.org/uniprot/G3QEG3|||http://purl.uniprot.org/uniprot/G3SD09 ^@ Function|||Subcellular Location Annotation ^@ Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.|||Cytoplasm http://togogenome.org/gene/9595:MX2 ^@ http://purl.uniprot.org/uniprot/G3QGS2 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/9595:PAX3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y6N5|||http://purl.uniprot.org/uniprot/G3SAM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/9595:ALG8 ^@ http://purl.uniprot.org/uniprot/G3R7I9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG6/ALG8 glucosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:APLN ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1U0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the apelin family.|||extracellular space http://togogenome.org/gene/9595:SEMA3C ^@ http://purl.uniprot.org/uniprot/G3RJN2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9595:PAMR1 ^@ http://purl.uniprot.org/uniprot/G3REC8|||http://purl.uniprot.org/uniprot/G3RYC2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:EMC2 ^@ http://purl.uniprot.org/uniprot/G3RR20 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC2 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. http://togogenome.org/gene/9595:LOC101125083 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZAH3 ^@ Subcellular Location Annotation ^@ mitochondrion nucleoid http://togogenome.org/gene/9595:ZSCAN5C ^@ http://purl.uniprot.org/uniprot/G3RDY2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:ELAC1 ^@ http://purl.uniprot.org/uniprot/G3QJI8 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/9595:NUDT1 ^@ http://purl.uniprot.org/uniprot/G3RNY0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family.|||Monomer.|||Nucleus http://togogenome.org/gene/9595:GNAL ^@ http://purl.uniprot.org/uniprot/G3RIY2 ^@ Similarity ^@ Belongs to the G-alpha family. G(s) subfamily. http://togogenome.org/gene/9595:CD79A ^@ http://purl.uniprot.org/uniprot/G3RGZ4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:CAMK1 ^@ http://purl.uniprot.org/uniprot/G3RED6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:KCNJ6 ^@ http://purl.uniprot.org/uniprot/A0A2I2YHE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.|||Membrane http://togogenome.org/gene/9595:AVPR1A ^@ http://purl.uniprot.org/uniprot/A0A2I2Z9B3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane|||Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. http://togogenome.org/gene/9595:LOC101142986 ^@ http://purl.uniprot.org/uniprot/G3RN90 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:SCAND1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TIX9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:VPS26B ^@ http://purl.uniprot.org/uniprot/G3QV91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS26 family.|||Endosome http://togogenome.org/gene/9595:ZC3H15 ^@ http://purl.uniprot.org/uniprot/G3QCX0 ^@ Similarity ^@ Belongs to the ZC3H15/TMA46 family. http://togogenome.org/gene/9595:MRPL17 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z344 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL17 family. http://togogenome.org/gene/9595:INHBE ^@ http://purl.uniprot.org/uniprot/G3QJX2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/9595:ZNF274 ^@ http://purl.uniprot.org/uniprot/G3RTC3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:LOC101154074 ^@ http://purl.uniprot.org/uniprot/G3R2L4 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:BTBD10 ^@ http://purl.uniprot.org/uniprot/G3QDD1|||http://purl.uniprot.org/uniprot/G3RXU9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:TSSC4 ^@ http://purl.uniprot.org/uniprot/G3QX83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TSSC4 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:XPA ^@ http://purl.uniprot.org/uniprot/A0A2I2Y279|||http://purl.uniprot.org/uniprot/G3QGB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPA family.|||Nucleus http://togogenome.org/gene/9595:TMEM170B ^@ http://purl.uniprot.org/uniprot/G3QUA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM170 family.|||Membrane http://togogenome.org/gene/9595:RGS2 ^@ http://purl.uniprot.org/uniprot/G3QJV6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||nucleolus http://togogenome.org/gene/9595:OTOF ^@ http://purl.uniprot.org/uniprot/G3RZU3 ^@ Similarity ^@ Belongs to the ferlin family. http://togogenome.org/gene/9595:CFAP126 ^@ http://purl.uniprot.org/uniprot/G3QYB5 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the Flattop family. http://togogenome.org/gene/9595:MINPP1 ^@ http://purl.uniprot.org/uniprot/G3QWU7 ^@ Similarity ^@ Belongs to the histidine acid phosphatase family. MINPP1 subfamily. http://togogenome.org/gene/9595:PSMB3 ^@ http://purl.uniprot.org/uniprot/G3QVX5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:ABAT ^@ http://purl.uniprot.org/uniprot/G3R3N6 ^@ Similarity|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9595:LOC101128557 ^@ http://purl.uniprot.org/uniprot/G3S5D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:HVCN1 ^@ http://purl.uniprot.org/uniprot/G3QN52 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the hydrogen channel family.|||Homodimer.|||Membrane http://togogenome.org/gene/9595:PARP14 ^@ http://purl.uniprot.org/uniprot/G3S362 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9595:PDGFRL ^@ http://purl.uniprot.org/uniprot/G3REV5 ^@ Subunit ^@ Forms a complex composed of PDGFRL, TNK2 and GRB2. http://togogenome.org/gene/9595:ENTREP3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z2I4|||http://purl.uniprot.org/uniprot/G3R1X5 ^@ Similarity ^@ Belongs to the ENTREP family. http://togogenome.org/gene/9595:LGI2 ^@ http://purl.uniprot.org/uniprot/G3S4D7 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9595:XRCC6 ^@ http://purl.uniprot.org/uniprot/G3RIJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ku70 family.|||Nucleus http://togogenome.org/gene/9595:LOC101131235 ^@ http://purl.uniprot.org/uniprot/G3S117 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MHC class I family.|||Endosome membrane|||Lysosome membrane http://togogenome.org/gene/9595:CMC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y7L1|||http://purl.uniprot.org/uniprot/G3R9L8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion http://togogenome.org/gene/9595:ORMDL1 ^@ http://purl.uniprot.org/uniprot/G3RGX6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/9595:RUNX1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YIQ6 ^@ Function|||Subcellular Location Annotation ^@ Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.|||Nucleus http://togogenome.org/gene/9595:THBS3 ^@ http://purl.uniprot.org/uniprot/G3R1N5 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:IGFL1 ^@ http://purl.uniprot.org/uniprot/G3R747 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IGFL family.|||Secreted http://togogenome.org/gene/9595:SLC5A1 ^@ http://purl.uniprot.org/uniprot/G3SHX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:EMC3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZL94 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC3 family.|||Component of the ER membrane protein complex (EMC).|||Membrane http://togogenome.org/gene/9595:FBXO34 ^@ http://purl.uniprot.org/uniprot/G3QVE0 ^@ Function ^@ Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. http://togogenome.org/gene/9595:LOC101136323 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZUI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:XKR5 ^@ http://purl.uniprot.org/uniprot/A0A2I2YUT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9595:PLAC8 ^@ http://purl.uniprot.org/uniprot/G3QWX8 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/9595:SERBP1 ^@ http://purl.uniprot.org/uniprot/G3R4E0 ^@ Similarity ^@ Belongs to the SERBP1-HABP4 family. http://togogenome.org/gene/9595:PDE2A ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1G1 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9595:FOXB2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZRB3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SRPRB ^@ http://purl.uniprot.org/uniprot/G3SG96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP receptor beta subunit family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:GATA1 ^@ http://purl.uniprot.org/uniprot/G3RS51 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:INHA ^@ http://purl.uniprot.org/uniprot/G3QM12 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.|||Secreted http://togogenome.org/gene/9595:LOC101125223 ^@ http://purl.uniprot.org/uniprot/A4H1Z9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Exhibits antimicrobial activity against Gram-positive and Gram-negative bacteria.|||Secreted http://togogenome.org/gene/9595:LOC101133280 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y3I3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9595:NR1D1 ^@ http://purl.uniprot.org/uniprot/G3R2J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9595:SHROOM1 ^@ http://purl.uniprot.org/uniprot/G3SF06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shroom family.|||cytoskeleton http://togogenome.org/gene/9595:HACL1 ^@ http://purl.uniprot.org/uniprot/G3R5G3 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/9595:HOXB2 ^@ http://purl.uniprot.org/uniprot/G3R360 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:HMGN3 ^@ http://purl.uniprot.org/uniprot/G3SDN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/9595:RPS25 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZJ21 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS25 family.|||Component of the small ribosomal subunit. http://togogenome.org/gene/9595:UTP23 ^@ http://purl.uniprot.org/uniprot/A0A2I2YP15 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9595:BLOC1S2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z9W6|||http://purl.uniprot.org/uniprot/A0A2I2ZX77 ^@ Similarity ^@ Belongs to the BLOC1S2 family. http://togogenome.org/gene/9595:RFTN1 ^@ http://purl.uniprot.org/uniprot/G3R0K1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the raftlin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:TCEA1 ^@ http://purl.uniprot.org/uniprot/G3S7T1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family.|||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.|||Nucleus http://togogenome.org/gene/9595:SEMA3D ^@ http://purl.uniprot.org/uniprot/G3RA65 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:TOR3A ^@ http://purl.uniprot.org/uniprot/A0A2I2ZGQ9 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. Torsin subfamily. http://togogenome.org/gene/9595:RPRD1B ^@ http://purl.uniprot.org/uniprot/G3QNP7 ^@ Function|||Similarity|||Subunit ^@ Associates with the RNA polymerase II complex.|||Belongs to the UPF0400 (RTT103) family.|||Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. http://togogenome.org/gene/9595:BOK ^@ http://purl.uniprot.org/uniprot/A0A2I2ZF28 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9595:ITIH1 ^@ http://purl.uniprot.org/uniprot/G3QSH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/9595:KDM3B ^@ http://purl.uniprot.org/uniprot/G3QEW8 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the JHDM2 histone demethylase family.|||Binds 1 Fe(2+) ion per subunit.|||Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.|||Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.|||Nucleus|||The JmjC domain and the C6-type zinc-finger are required for the demethylation activity. http://togogenome.org/gene/9595:FHIP1A ^@ http://purl.uniprot.org/uniprot/G3RKA8 ^@ Similarity ^@ Belongs to the FHIP family. http://togogenome.org/gene/9595:LOC101153071 ^@ http://purl.uniprot.org/uniprot/G3QVI9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9595:YPEL5 ^@ http://purl.uniprot.org/uniprot/G3S733 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9595:NDUFS3 ^@ http://purl.uniprot.org/uniprot/Q0MQG7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 30 kDa subunit family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (By similarity). Interacts with NDUFAF3 (By similarity). Interacts with RAB5IF (By similarity). Found in subcomplexes containing subunits NDUFS2, MT-ND1 and NDUFA13 (By similarity).|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (By similarity). Essential for the catalytic activity and assembly of complex I (By similarity).|||Mitochondrion inner membrane http://togogenome.org/gene/9595:IFI30 ^@ http://purl.uniprot.org/uniprot/G3R964 ^@ Similarity|||Subunit ^@ Belongs to the GILT family.|||Dimer; disulfide-linked. http://togogenome.org/gene/9595:ZSCAN9 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y5J7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:DNAJA1 ^@ http://purl.uniprot.org/uniprot/G3QVU3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:NELL2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y6W4|||http://purl.uniprot.org/uniprot/A0A2I2Z2V4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:LOC101147054 ^@ http://purl.uniprot.org/uniprot/G3QSH7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:MBL2 ^@ http://purl.uniprot.org/uniprot/Q66S60 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity).|||Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.|||Oligomeric complex of 3 or more homotrimers. Interacts with MASP1 and MASP2 (By similarity). Interacts with MEP1A and MEP1B and may inhibit their catalytic activity (By similarity).|||Secreted|||The coiled-coil domain mediates trimerization. http://togogenome.org/gene/9595:FGFR2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZVK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:C15H15orf40 ^@ http://purl.uniprot.org/uniprot/G3RPN2 ^@ Similarity ^@ Belongs to the UPF0235 family. http://togogenome.org/gene/9595:AARS2 ^@ http://purl.uniprot.org/uniprot/G3QRY8 ^@ Caution|||Cofactor|||Domain|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||ISGylated.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Interacts with ANKRD16; the interaction is direct. http://togogenome.org/gene/9595:PMS1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y7B3|||http://purl.uniprot.org/uniprot/A0A2I2ZTS4 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/9595:EDN3 ^@ http://purl.uniprot.org/uniprot/G3RAU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Secreted http://togogenome.org/gene/9595:ACTL8 ^@ http://purl.uniprot.org/uniprot/G3RFH6 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9595:EXOSC8 ^@ http://purl.uniprot.org/uniprot/G3R8A9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:CXCR5 ^@ http://purl.uniprot.org/uniprot/G3RDW5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:ZIC1 ^@ http://purl.uniprot.org/uniprot/G3SI03 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/9595:EMX2 ^@ http://purl.uniprot.org/uniprot/G3RKJ4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:LOC101131824 ^@ http://purl.uniprot.org/uniprot/G3S4C2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:TRARG1 ^@ http://purl.uniprot.org/uniprot/G3SCX6 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9595:DMBX1 ^@ http://purl.uniprot.org/uniprot/G3R8Q8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:RFT1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YZP1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RFT1 family.|||May be involved in N-linked oligosaccharide assembly.|||Membrane http://togogenome.org/gene/9595:PLA2G4A ^@ http://purl.uniprot.org/uniprot/G3R9G5 ^@ Domain ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding. http://togogenome.org/gene/9595:SIDT2 ^@ http://purl.uniprot.org/uniprot/G3SJA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SID1 family.|||Membrane http://togogenome.org/gene/9595:DRAM2 ^@ http://purl.uniprot.org/uniprot/G3R2A4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:MTMR2 ^@ http://purl.uniprot.org/uniprot/G3RYF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/9595:OTULIN ^@ http://purl.uniprot.org/uniprot/A0A2I2Z0M6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C65 family. Otulin subfamily.|||Cytoplasm http://togogenome.org/gene/9595:EPHA7 ^@ http://purl.uniprot.org/uniprot/G3QUG2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:CDO1 ^@ http://purl.uniprot.org/uniprot/G3RJL8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the cysteine dioxygenase family.|||Binds 1 Fe cation per subunit.|||Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen. http://togogenome.org/gene/9595:PRKCE ^@ http://purl.uniprot.org/uniprot/G3R8H1 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration.|||Cell membrane|||Cytoplasm|||Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.|||Nucleus|||cytoskeleton|||perinuclear region http://togogenome.org/gene/9595:AVIL ^@ http://purl.uniprot.org/uniprot/G3QGE5 ^@ Similarity ^@ Belongs to the villin/gelsolin family. http://togogenome.org/gene/9595:MCEE ^@ http://purl.uniprot.org/uniprot/G3RZF8 ^@ Similarity ^@ Belongs to the methylmalonyl-CoA epimerase family. http://togogenome.org/gene/9595:KCNK9 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZP69 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane|||pH-dependent, voltage-insensitive, background potassium channel protein. http://togogenome.org/gene/9595:CTPS2 ^@ http://purl.uniprot.org/uniprot/G3QVM9 ^@ Function|||Similarity ^@ Belongs to the CTP synthase family.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. http://togogenome.org/gene/9595:AZIN2 ^@ http://purl.uniprot.org/uniprot/G3RFZ8 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/9595:LOC101141171 ^@ http://purl.uniprot.org/uniprot/G3RI60 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DIPP subfamily. http://togogenome.org/gene/9595:GOT1 ^@ http://purl.uniprot.org/uniprot/G3QJC1 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/9595:APEH ^@ http://purl.uniprot.org/uniprot/G3R4V3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S9C family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/9595:P2RY4 ^@ http://purl.uniprot.org/uniprot/G3QEC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ST6GALNAC1 ^@ http://purl.uniprot.org/uniprot/G3QCR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9595:LOC101133462 ^@ http://purl.uniprot.org/uniprot/G3R477 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:IGFBP4 ^@ http://purl.uniprot.org/uniprot/G3R338 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Binds IGF2 more than IGF1.|||IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9595:KRR1 ^@ http://purl.uniprot.org/uniprot/G3RCN2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KRR1 family.|||Component of the ribosomal small subunit (SSU) processome.|||Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.|||nucleolus http://togogenome.org/gene/9595:SUCLG1 ^@ http://purl.uniprot.org/uniprot/G3QI12 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).|||Mitochondrion|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. http://togogenome.org/gene/9595:CDH7 ^@ http://purl.uniprot.org/uniprot/G3R6F1 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:HOMEZ ^@ http://purl.uniprot.org/uniprot/G3QIF1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:KDSR ^@ http://purl.uniprot.org/uniprot/G3RBX4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9595:MOSPD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YJN6|||http://purl.uniprot.org/uniprot/G3QMM4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:RIOK2 ^@ http://purl.uniprot.org/uniprot/G3RZ18 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/9595:ACO2 ^@ http://purl.uniprot.org/uniprot/G3QFL5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.|||Mitochondrion http://togogenome.org/gene/9595:FDFT1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YI48|||http://purl.uniprot.org/uniprot/G3QFR9 ^@ Function|||Similarity ^@ Belongs to the phytoene/squalene synthase family.|||Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. http://togogenome.org/gene/9595:ATP8A1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZP07|||http://purl.uniprot.org/uniprot/G3SEF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9595:LOC101144727 ^@ http://purl.uniprot.org/uniprot/G3QWL4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c-type heme lyase family.|||Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9595:IGF2BP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z4W1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM IMP/VICKZ family.|||Nucleus|||P-body|||Stress granule|||filopodium|||growth cone|||lamellipodium|||perinuclear region http://togogenome.org/gene/9595:GSDME ^@ http://purl.uniprot.org/uniprot/G3QR26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gasdermin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:YTHDF3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YIF6 ^@ Function|||Similarity ^@ Belongs to the YTHDF family.|||Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. http://togogenome.org/gene/9595:MRPL27 ^@ http://purl.uniprot.org/uniprot/G3SCT0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/9595:POU6F1 ^@ http://purl.uniprot.org/uniprot/G3QDB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/9595:ADAMTS18 ^@ http://purl.uniprot.org/uniprot/G3SKG9 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9595:RTN3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YL16|||http://purl.uniprot.org/uniprot/A0A2I2Z8W7 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:TRPC4 ^@ http://purl.uniprot.org/uniprot/G3QW39 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:DMRT1 ^@ http://purl.uniprot.org/uniprot/G3S0W9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/9595:FAM229B ^@ http://purl.uniprot.org/uniprot/G3RG91 ^@ Similarity ^@ Belongs to the FAM229 family. http://togogenome.org/gene/9595:PROZ ^@ http://purl.uniprot.org/uniprot/G3QDS4|||http://purl.uniprot.org/uniprot/G3SHG4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:AQP4 ^@ http://purl.uniprot.org/uniprot/G3R4L3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9595:MAGOHB ^@ http://purl.uniprot.org/uniprot/A0A2I2Y2C4|||http://purl.uniprot.org/uniprot/A0A2I2YIF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mago nashi family.|||Nucleus http://togogenome.org/gene/9595:FGD6 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y251 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9595:NUS1 ^@ http://purl.uniprot.org/uniprot/G3SFP4 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/9595:PNPLA6 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZTV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NTE family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:LIPC ^@ http://purl.uniprot.org/uniprot/G3QYK3 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9595:RPL30 ^@ http://purl.uniprot.org/uniprot/G3QRX3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/9595:SPDEF ^@ http://purl.uniprot.org/uniprot/G3QDQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9595:HAUS3 ^@ http://purl.uniprot.org/uniprot/G3QEN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HAUS3 family.|||spindle http://togogenome.org/gene/9595:PLXNB3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YXF1|||http://purl.uniprot.org/uniprot/G3RNG4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the plexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:IL21 ^@ http://purl.uniprot.org/uniprot/G3QY93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Secreted http://togogenome.org/gene/9595:C5H5orf63 ^@ http://purl.uniprot.org/uniprot/G3QTF9 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/9595:LMBR1L ^@ http://purl.uniprot.org/uniprot/G3RWF7 ^@ Similarity ^@ Belongs to the LIMR family. http://togogenome.org/gene/9595:ATP5PF ^@ http://purl.uniprot.org/uniprot/G3SFN3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ATPase subunit F6 family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.|||Mitochondrion|||Mitochondrion inner membrane http://togogenome.org/gene/9595:PTPN12 ^@ http://purl.uniprot.org/uniprot/G3SHJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.|||Cytoplasm|||Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. http://togogenome.org/gene/9595:LOC101148015 ^@ http://purl.uniprot.org/uniprot/G3RQ20 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9595:MMP10 ^@ http://purl.uniprot.org/uniprot/G3RUD4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9595:ASIC5 ^@ http://purl.uniprot.org/uniprot/G3SHE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.|||Membrane http://togogenome.org/gene/9595:LOC101141279 ^@ http://purl.uniprot.org/uniprot/P30378 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MHC class I family.|||Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).|||Involved in the presentation of foreign antigens to the immune system.|||Membrane http://togogenome.org/gene/9595:LOC101149308 ^@ http://purl.uniprot.org/uniprot/G3QI10 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:SDR42E1 ^@ http://purl.uniprot.org/uniprot/G3RBJ8 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9595:LOC101141727 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y424 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9595:PCYT2 ^@ http://purl.uniprot.org/uniprot/G3RDK2 ^@ Similarity ^@ Belongs to the cytidylyltransferase family. http://togogenome.org/gene/9595:DUXB ^@ http://purl.uniprot.org/uniprot/A0A2I2ZA34 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:PRDM12 ^@ http://purl.uniprot.org/uniprot/G3S4A4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily.|||Involved in the positive regulation of histone H3-K9 dimethylation.|||Nucleus http://togogenome.org/gene/9595:MED7 ^@ http://purl.uniprot.org/uniprot/G3QJD1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 7 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9595:HOMER2 ^@ http://purl.uniprot.org/uniprot/G3RI65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Homer family.|||Cytoplasm|||Postsynaptic density|||Synapse http://togogenome.org/gene/9595:TXLNA ^@ http://purl.uniprot.org/uniprot/G3QGT7 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/9595:HOXB6 ^@ http://purl.uniprot.org/uniprot/G3QJJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9595:LOC101144197 ^@ http://purl.uniprot.org/uniprot/G3QKY9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS1 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.|||Cytoplasm|||May play a role during erythropoiesis through regulation of transcription factor DDIT3.|||Nucleus|||nucleolus http://togogenome.org/gene/9595:GLDN ^@ http://purl.uniprot.org/uniprot/G3QLN5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:OPA3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z4S0|||http://purl.uniprot.org/uniprot/G3S0L1 ^@ Function|||Similarity ^@ Belongs to the OPA3 family.|||May play some role in mitochondrial processes. http://togogenome.org/gene/9595:TLR2 ^@ http://purl.uniprot.org/uniprot/B3Y615 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Toll-like receptor family.|||Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (By similarity).|||Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12.|||Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.|||In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity.|||Interacts with LY96, TLR1 and TLR6 (via extracellular domain). TLR2 seems to exist in heterodimers with either TLR1 or TLR6 before stimulation by the ligand. The heterodimers form bigger oligomers in response to their corresponding ligands as well as further heterotypic associations with other receptors such as CD14 and/or CD36. Binds MYD88 (via TIR domain). Interacts with TICAM1. Interacts with CNPY3. Interacts with ATG16L1. Interacts with PPP1R11. Interacts with TICAM2. Interacts with TIRAP (By similarity).|||Membrane|||Membrane raft|||The ATG16L1-binding motif mediates interaction with ATG16L1.|||Ubiquitinated at Lys-754 by PPP1R11, leading to its degradation. Deubiquitinated by USP2.|||phagosome membrane http://togogenome.org/gene/9595:PKP1 ^@ http://purl.uniprot.org/uniprot/G3RPR6 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/9595:NEU1 ^@ http://purl.uniprot.org/uniprot/G3R0S0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/9595:PTHLH ^@ http://purl.uniprot.org/uniprot/A0A2I2Z7L9|||http://purl.uniprot.org/uniprot/G3RRH1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the parathyroid hormone family.|||Cytoplasm|||Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath.|||Nucleus|||Osteostatin is a potent inhibitor of osteoclastic bone resorption.|||PTHrP interacts with PTH1R (via N-terminal extracellular domain).|||Secreted|||There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions. http://togogenome.org/gene/9595:POMGNT1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YUD3|||http://purl.uniprot.org/uniprot/A0A2I2ZHP4|||http://purl.uniprot.org/uniprot/G3QIV6 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 13 family.|||Golgi apparatus membrane|||Membrane|||Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.|||The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.|||The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein. http://togogenome.org/gene/9595:MSTN ^@ http://purl.uniprot.org/uniprot/A1C2V5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts specifically as a negative regulator of skeletal muscle growth.|||Belongs to the TGF-beta family.|||Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FSTL3.|||Secreted|||Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule. The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase. http://togogenome.org/gene/9595:GATB ^@ http://purl.uniprot.org/uniprot/G3R678 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/9595:CFAP300 ^@ http://purl.uniprot.org/uniprot/G3QFA8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP300 family.|||Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.|||Cytoplasm http://togogenome.org/gene/9595:LOC101149484 ^@ http://purl.uniprot.org/uniprot/G3RGC9 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/9595:MFSD4A ^@ http://purl.uniprot.org/uniprot/A0A2I2YVS2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:MYSM1 ^@ http://purl.uniprot.org/uniprot/G3QR94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M67A family. MYSM1 subfamily.|||Nucleus http://togogenome.org/gene/9595:MRPS7 ^@ http://purl.uniprot.org/uniprot/G3QXD3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS7 family. http://togogenome.org/gene/9595:KDR ^@ http://purl.uniprot.org/uniprot/G3RAP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:FBL ^@ http://purl.uniprot.org/uniprot/G3RZC3 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Fibrillarin family. http://togogenome.org/gene/9595:RPAP1 ^@ http://purl.uniprot.org/uniprot/G3QVU2 ^@ Similarity ^@ Belongs to the RPAP1 family. http://togogenome.org/gene/9595:SIX6 ^@ http://purl.uniprot.org/uniprot/G3RXM7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:STEAP4 ^@ http://purl.uniprot.org/uniprot/G3RBZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9595:DLGAP3 ^@ http://purl.uniprot.org/uniprot/G3RC00 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/9595:TOMM40L ^@ http://purl.uniprot.org/uniprot/A0A2I2Z5F0|||http://purl.uniprot.org/uniprot/G3QSG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom40 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9595:LOC101139480 ^@ http://purl.uniprot.org/uniprot/G3RW14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:TRUB1 ^@ http://purl.uniprot.org/uniprot/G3QPK0 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/9595:RAG2 ^@ http://purl.uniprot.org/uniprot/G3SIQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAG2 family.|||Nucleus http://togogenome.org/gene/9595:ADRB3 ^@ http://purl.uniprot.org/uniprot/G3S5Q3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.|||Cell membrane|||Interacts with ARRDC3.|||Membrane http://togogenome.org/gene/9595:RFX2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YYL4|||http://purl.uniprot.org/uniprot/A0A2I2ZGI5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:LOC101130985 ^@ http://purl.uniprot.org/uniprot/G3QXG0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9595:MED11 ^@ http://purl.uniprot.org/uniprot/G3QRU5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 11 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9595:TRPC5 ^@ http://purl.uniprot.org/uniprot/G3RIJ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:SYNGR1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YTA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptogyrin family.|||Membrane http://togogenome.org/gene/9595:ITGAX ^@ http://purl.uniprot.org/uniprot/G3RA67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9595:TBPL1 ^@ http://purl.uniprot.org/uniprot/G3RU70 ^@ Similarity|||Subunit ^@ Belongs to the TBP family.|||Binds TFIIA and TFIIB. http://togogenome.org/gene/9595:HDAC2 ^@ http://purl.uniprot.org/uniprot/G3QRQ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.|||Nucleus http://togogenome.org/gene/9595:LOC101139685 ^@ http://purl.uniprot.org/uniprot/G3QSR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MHC class I family.|||Belongs to the MHC class II family.|||Endosome membrane|||Lysosome membrane http://togogenome.org/gene/9595:DOCK8 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z9P1|||http://purl.uniprot.org/uniprot/G3R0C4 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9595:RPS6KA3 ^@ http://purl.uniprot.org/uniprot/G3R0F8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9595:ADAMDEC1 ^@ http://purl.uniprot.org/uniprot/G3QFW5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:ERRFI1 ^@ http://purl.uniprot.org/uniprot/G3QU83 ^@ Subcellular Location Annotation ^@ Membrane|||Nucleus http://togogenome.org/gene/9595:TM2D2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YX34 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:PKIA ^@ http://purl.uniprot.org/uniprot/G3RTH0 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/9595:ATP6V1G2 ^@ http://purl.uniprot.org/uniprot/G3QT58 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9595:ATP5PB ^@ http://purl.uniprot.org/uniprot/G3QR73 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ATPase B chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) has three main subunits: a, b and c.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion|||Mitochondrion inner membrane http://togogenome.org/gene/9595:SDHB ^@ http://purl.uniprot.org/uniprot/G3RJI3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster.|||Binds 1 [3Fe-4S] cluster.|||Binds 1 [4Fe-4S] cluster.|||Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/9595:GSTA4 ^@ http://purl.uniprot.org/uniprot/G3QRL1 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/9595:OPALIN ^@ http://purl.uniprot.org/uniprot/A0A2I2ZRR1|||http://purl.uniprot.org/uniprot/G3QF24 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation.|||Membrane http://togogenome.org/gene/9595:FCER1G ^@ http://purl.uniprot.org/uniprot/A0A2I2YN14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD3Z/FCER1G family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ASB15 ^@ http://purl.uniprot.org/uniprot/G3QZR9 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9595:ZSCAN25 ^@ http://purl.uniprot.org/uniprot/G3RLA2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:CNNM4 ^@ http://purl.uniprot.org/uniprot/G3R3R2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ACDP family.|||Cell membrane|||Membrane|||Metal transporter. http://togogenome.org/gene/9595:CTNNA2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y9A3|||http://purl.uniprot.org/uniprot/A0A2I2YNA1|||http://purl.uniprot.org/uniprot/G3RRY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vinculin/alpha-catenin family.|||Cell membrane|||Membrane|||adherens junction http://togogenome.org/gene/9595:PDK2 ^@ http://purl.uniprot.org/uniprot/G3RHS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9595:MAN2B1 ^@ http://purl.uniprot.org/uniprot/G3RC23 ^@ Cofactor|||Similarity ^@ Belongs to the glycosyl hydrolase 38 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9595:NAT10 ^@ http://purl.uniprot.org/uniprot/G3RF58 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.|||Interacts with THUMPD1.|||RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.|||nucleolus http://togogenome.org/gene/9595:FGF1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YI26|||http://purl.uniprot.org/uniprot/G3RPE3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heparin-binding growth factors family.|||Cytoplasm|||Nucleus|||Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.|||Secreted|||cell cortex|||cytosol http://togogenome.org/gene/9595:ETV4 ^@ http://purl.uniprot.org/uniprot/G3QD39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9595:ITGA7 ^@ http://purl.uniprot.org/uniprot/A0A2I2YSG4|||http://purl.uniprot.org/uniprot/A0A2I2Z3P5|||http://purl.uniprot.org/uniprot/A0A2I2ZTX6|||http://purl.uniprot.org/uniprot/G3QKX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9595:IL17C ^@ http://purl.uniprot.org/uniprot/G3R9X0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/9595:LIAS ^@ http://purl.uniprot.org/uniprot/A0A2I2YM44|||http://purl.uniprot.org/uniprot/G3SER2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion http://togogenome.org/gene/9595:PRR23A ^@ http://purl.uniprot.org/uniprot/G3QHM8 ^@ Similarity ^@ Belongs to the PRR23 family. http://togogenome.org/gene/9595:EIF1 ^@ http://purl.uniprot.org/uniprot/G3SHY9 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/9595:MICAL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZFJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mical family.|||Cytoplasm http://togogenome.org/gene/9595:STT3A ^@ http://purl.uniprot.org/uniprot/G3R313 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/9595:TRAK2 ^@ http://purl.uniprot.org/uniprot/G3QKJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the milton family.|||Early endosome|||Mitochondrion http://togogenome.org/gene/9595:UGT2B4 ^@ http://purl.uniprot.org/uniprot/G3RWI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9595:DCK ^@ http://purl.uniprot.org/uniprot/A0A2I2YPC2 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/9595:LOC109029219 ^@ http://purl.uniprot.org/uniprot/A0A2I2YF52 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9595:NSUN2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YDN2|||http://purl.uniprot.org/uniprot/A0A2I2Z719 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||extracellular exosome http://togogenome.org/gene/9595:WDR82 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZBG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SWD2 family.|||Nucleus http://togogenome.org/gene/9595:ABCD4 ^@ http://purl.uniprot.org/uniprot/G3QJF4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:GRB2 ^@ http://purl.uniprot.org/uniprot/G3QTG9 ^@ Subcellular Location Annotation ^@ Endosome|||Golgi apparatus|||Nucleus http://togogenome.org/gene/9595:LOC101152650 ^@ http://purl.uniprot.org/uniprot/G3S6G5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS26 family. http://togogenome.org/gene/9595:TRPT1 ^@ http://purl.uniprot.org/uniprot/G3S681 ^@ Function|||Similarity ^@ Belongs to the KptA/TPT1 family.|||Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate. http://togogenome.org/gene/9595:SLC22A8 ^@ http://purl.uniprot.org/uniprot/G3RTH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.|||Cell membrane http://togogenome.org/gene/9595:SLC9A1 ^@ http://purl.uniprot.org/uniprot/G3QGW0 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9595:TMEM168 ^@ http://purl.uniprot.org/uniprot/G3RLW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM168 family.|||Membrane|||Nucleus membrane http://togogenome.org/gene/9595:LOC101153318 ^@ http://purl.uniprot.org/uniprot/G3R0D4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:THAP10 ^@ http://purl.uniprot.org/uniprot/G3RDJ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the THAP1 family.|||DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.|||Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.|||nucleoplasm http://togogenome.org/gene/9595:PPDPFL ^@ http://purl.uniprot.org/uniprot/G3QT11 ^@ Similarity ^@ Belongs to the PPDPF family. http://togogenome.org/gene/9595:SLC1A4 ^@ http://purl.uniprot.org/uniprot/G3R6H7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9595:AARSD1 ^@ http://purl.uniprot.org/uniprot/G3SH26 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily. http://togogenome.org/gene/9595:MDFI ^@ http://purl.uniprot.org/uniprot/G3QJP1 ^@ Similarity ^@ Belongs to the MDFI family. http://togogenome.org/gene/9595:SMC4 ^@ http://purl.uniprot.org/uniprot/G3RD13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family.|||Chromosome|||Nucleus http://togogenome.org/gene/9595:RPL3L ^@ http://purl.uniprot.org/uniprot/G3R1R9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/9595:FLVCR1 ^@ http://purl.uniprot.org/uniprot/G3QH88 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:RBP2 ^@ http://purl.uniprot.org/uniprot/G3R438 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9595:SLIT1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YCZ6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9595:CBX5 ^@ http://purl.uniprot.org/uniprot/G3QCU2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:IL4I1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z3B6|||http://purl.uniprot.org/uniprot/G3RPA7 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/9595:C4A ^@ http://purl.uniprot.org/uniprot/A0A2I2YEP2 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9595:ERMP1 ^@ http://purl.uniprot.org/uniprot/G3QHK7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:SPTY2D1 ^@ http://purl.uniprot.org/uniprot/G3R4C5 ^@ Similarity ^@ Belongs to the SPT2 family. http://togogenome.org/gene/9595:SH3BGRL ^@ http://purl.uniprot.org/uniprot/G3SIZ4 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/9595:XCR1 ^@ http://purl.uniprot.org/uniprot/G3S0Y6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:PFDN6 ^@ http://purl.uniprot.org/uniprot/A0A2I2YD85 ^@ Function|||Similarity ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. http://togogenome.org/gene/9595:PGAP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YM28 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI inositol-deacylase family.|||Endoplasmic reticulum membrane|||Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.|||Membrane http://togogenome.org/gene/9595:PALM2AKAP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZUV6 ^@ Similarity ^@ Belongs to the paralemmin family. http://togogenome.org/gene/9595:UBR2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZWA2|||http://purl.uniprot.org/uniprot/G3QNA5 ^@ Function|||Similarity ^@ Belongs to the UBR1 family.|||Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. http://togogenome.org/gene/9595:MC2R ^@ http://purl.uniprot.org/uniprot/G3QPS8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).|||Membrane http://togogenome.org/gene/9595:FAM168B ^@ http://purl.uniprot.org/uniprot/G3QCX4 ^@ Similarity ^@ Belongs to the FAM168 family. http://togogenome.org/gene/9595:LOC101151609 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZBU0 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9595:VPS26C ^@ http://purl.uniprot.org/uniprot/G3SB23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS26 family.|||Endosome http://togogenome.org/gene/9595:DPPA5 ^@ http://purl.uniprot.org/uniprot/G3R8J3 ^@ Similarity ^@ Belongs to the KHDC1 family. http://togogenome.org/gene/9595:SMG5 ^@ http://purl.uniprot.org/uniprot/G3R5S7 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Plays a role in nonsense-mediated mRNA decay. http://togogenome.org/gene/9595:LOC101141950 ^@ http://purl.uniprot.org/uniprot/G3S9H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:TAC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YSA3|||http://purl.uniprot.org/uniprot/A0A2I2ZIT3|||http://purl.uniprot.org/uniprot/G3RDY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tachykinin family.|||Secreted|||Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. http://togogenome.org/gene/9595:EFTUD2 ^@ http://purl.uniprot.org/uniprot/G3RB35 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:KIF3C ^@ http://purl.uniprot.org/uniprot/G3QYI7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9595:SELE ^@ http://purl.uniprot.org/uniprot/G3QSS4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the selectin/LECAM family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:GDI2 ^@ http://purl.uniprot.org/uniprot/G3S4K5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP. http://togogenome.org/gene/9595:IGF2R ^@ http://purl.uniprot.org/uniprot/G3QH23 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:EAF2 ^@ http://purl.uniprot.org/uniprot/G3SAD5 ^@ Similarity ^@ Belongs to the EAF family. http://togogenome.org/gene/9595:YBEY ^@ http://purl.uniprot.org/uniprot/A0A2I2YQQ5 ^@ Similarity ^@ Belongs to the endoribonuclease YbeY family. http://togogenome.org/gene/9595:LPCAT4 ^@ http://purl.uniprot.org/uniprot/G3QXF8 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9595:PLP2 ^@ http://purl.uniprot.org/uniprot/G3RTV4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:MRPL14 ^@ http://purl.uniprot.org/uniprot/G3QTE8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL14 family. http://togogenome.org/gene/9595:ARG2 ^@ http://purl.uniprot.org/uniprot/G3QS73 ^@ Cofactor|||Similarity ^@ Belongs to the arginase family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9595:MINDY3 ^@ http://purl.uniprot.org/uniprot/G3R5Q3 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM188 subfamily.|||Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. http://togogenome.org/gene/9595:ETV1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y8B8|||http://purl.uniprot.org/uniprot/A0A2I2Z0A8|||http://purl.uniprot.org/uniprot/A0A2I2ZVN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9595:FGB ^@ http://purl.uniprot.org/uniprot/G3RDU2 ^@ Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted http://togogenome.org/gene/9595:NDUFB8 ^@ http://purl.uniprot.org/uniprot/Q0MQE6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB8 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:MOCS3 ^@ http://purl.uniprot.org/uniprot/G3R0V0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds 1 zinc ion per subunit.|||Cytoplasm|||In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.|||Interacts with NFS1.|||Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions. http://togogenome.org/gene/9595:CD28 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y8P2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:NMNAT1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YBT2 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/9595:NSRP1 ^@ http://purl.uniprot.org/uniprot/G3RTX8 ^@ Similarity ^@ Belongs to the NSRP1 family. http://togogenome.org/gene/9595:NPRL2 ^@ http://purl.uniprot.org/uniprot/G3QW21 ^@ Similarity ^@ Belongs to the NPR2 family. http://togogenome.org/gene/9595:CDC20B ^@ http://purl.uniprot.org/uniprot/A0A2I2ZT37|||http://purl.uniprot.org/uniprot/G3RQG4 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/9595:TRAPPC1 ^@ http://purl.uniprot.org/uniprot/G3QUA5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/9595:CDH6 ^@ http://purl.uniprot.org/uniprot/G3RLA5 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:PUF60 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y9K9|||http://purl.uniprot.org/uniprot/A0A2I2ZC99|||http://purl.uniprot.org/uniprot/G3QPQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM half pint family.|||Nucleus http://togogenome.org/gene/9595:SLC7A10 ^@ http://purl.uniprot.org/uniprot/G3QTE3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:C3AR1 ^@ http://purl.uniprot.org/uniprot/G3RG02 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Interacts with VGF-derived peptide TLQP-21.|||Membrane|||Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. http://togogenome.org/gene/9595:ABCC10 ^@ http://purl.uniprot.org/uniprot/A0A2I2YRY6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:RNF31 ^@ http://purl.uniprot.org/uniprot/G3RIX6 ^@ Similarity ^@ Belongs to the RBR family. http://togogenome.org/gene/9595:CLUH ^@ http://purl.uniprot.org/uniprot/G3RCB9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CLU family.|||Cytoplasm|||Cytoplasmic granule|||mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis. http://togogenome.org/gene/9595:ENAH ^@ http://purl.uniprot.org/uniprot/A0A2I2Y910 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ena/VASP family.|||cytoskeleton http://togogenome.org/gene/9595:EYA2 ^@ http://purl.uniprot.org/uniprot/G3SKP8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/9595:OLFML3 ^@ http://purl.uniprot.org/uniprot/G3R9Q6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:POLR1C ^@ http://purl.uniprot.org/uniprot/G3R5P7 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/9595:FMNL2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z7A4 ^@ Similarity ^@ Belongs to the formin homology family. http://togogenome.org/gene/9595:TMEM244 ^@ http://purl.uniprot.org/uniprot/G3RXN8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:MS4A10 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZBN5 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9595:PELI3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YYQ0|||http://purl.uniprot.org/uniprot/G3RBN9 ^@ Function|||Similarity ^@ Belongs to the pellino family.|||E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. http://togogenome.org/gene/9595:SYS1 ^@ http://purl.uniprot.org/uniprot/G3QNG1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SYS1 family.|||Golgi apparatus membrane|||Interacts with ARFRP1.|||Involved in protein trafficking. May serve as a receptor for ARFRP1.|||Membrane http://togogenome.org/gene/9595:SLC6A9 ^@ http://purl.uniprot.org/uniprot/G3QM65|||http://purl.uniprot.org/uniprot/G3S6N9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ACOX3 ^@ http://purl.uniprot.org/uniprot/G3RSD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/9595:POLR2I ^@ http://purl.uniprot.org/uniprot/G3RHC8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/9595:IL1RAPL1 ^@ http://purl.uniprot.org/uniprot/G3QKJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the interleukin-1 receptor family.|||axon|||dendrite http://togogenome.org/gene/9595:ELOVL1 ^@ http://purl.uniprot.org/uniprot/G3R4H1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ELO family. ELOVL1 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.|||Endoplasmic reticulum membrane|||Interacts with LASS2, TECR and HSD17B12.|||Membrane|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9595:IZUMO3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YUM5|||http://purl.uniprot.org/uniprot/G3R790 ^@ Similarity ^@ Belongs to the Izumo family. http://togogenome.org/gene/9595:ATP6V0E1 ^@ http://purl.uniprot.org/uniprot/G3QUZ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase e1/e2 subunit family.|||Membrane|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9595:MARVELD2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y6F8|||http://purl.uniprot.org/uniprot/G3RHQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9595:GNG12 ^@ http://purl.uniprot.org/uniprot/A0A2I2YIX9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9595:RHD ^@ http://purl.uniprot.org/uniprot/Q28427 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.|||Membrane http://togogenome.org/gene/9595:PAQR5 ^@ http://purl.uniprot.org/uniprot/G3QMZ6|||http://purl.uniprot.org/uniprot/G3S7G0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9595:DZIP3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YK06 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:WNT3 ^@ http://purl.uniprot.org/uniprot/G3RQ89 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9595:DGKZ ^@ http://purl.uniprot.org/uniprot/A0A2I2Y9C5|||http://purl.uniprot.org/uniprot/G3S053 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/9595:SCRN2 ^@ http://purl.uniprot.org/uniprot/G3QPG3 ^@ Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily. http://togogenome.org/gene/9595:SGIP1 ^@ http://purl.uniprot.org/uniprot/G3RU21 ^@ Function|||Subcellular Location Annotation ^@ May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis.|||clathrin-coated pit http://togogenome.org/gene/9595:BEX2 ^@ http://purl.uniprot.org/uniprot/G3QS69 ^@ Similarity ^@ Belongs to the BEX family. http://togogenome.org/gene/9595:INO80D ^@ http://purl.uniprot.org/uniprot/G3RHR4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:LUC7L2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1F0|||http://purl.uniprot.org/uniprot/G3RKD8 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/9595:NKX3-1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YFJ4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:CDSN ^@ http://purl.uniprot.org/uniprot/G3S1W3 ^@ Function|||Subcellular Location Annotation ^@ Important for the epidermal barrier integrity.|||Secreted http://togogenome.org/gene/9595:OXA1L ^@ http://purl.uniprot.org/uniprot/G3SFA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OXA1/ALB3/YidC family.|||Membrane http://togogenome.org/gene/9595:SERF2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y1V5 ^@ Similarity ^@ Belongs to the SERF family. http://togogenome.org/gene/9595:CDC34 ^@ http://purl.uniprot.org/uniprot/G3QL57 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9595:UBA6 ^@ http://purl.uniprot.org/uniprot/G3RFM5 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/9595:ITGB7 ^@ http://purl.uniprot.org/uniprot/G3QV88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:RBM42 ^@ http://purl.uniprot.org/uniprot/A0A2I2YME1|||http://purl.uniprot.org/uniprot/G3RVH6 ^@ Similarity ^@ Belongs to the RRM RBM42 family. http://togogenome.org/gene/9595:STATH ^@ http://purl.uniprot.org/uniprot/G3SG71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histatin/statherin family.|||Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface.|||Secreted http://togogenome.org/gene/9595:EIF3I ^@ http://purl.uniprot.org/uniprot/G3QGU3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit I family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm|||Phosphorylated by TGF-beta type II receptor. http://togogenome.org/gene/9595:SF3A3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YA81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3A3 family.|||Nucleus http://togogenome.org/gene/9595:BCL2 ^@ http://purl.uniprot.org/uniprot/G3QES9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion outer membrane|||Nucleus membrane http://togogenome.org/gene/9595:LOC101146890 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y4K8|||http://purl.uniprot.org/uniprot/A0A2I2Z8Q8|||http://purl.uniprot.org/uniprot/G3QRS3 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/9595:KRT16 ^@ http://purl.uniprot.org/uniprot/G3RAL7 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:FTHL17 ^@ http://purl.uniprot.org/uniprot/G3QY39 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/9595:RPL23 ^@ http://purl.uniprot.org/uniprot/G3SHW8 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/9595:LOC101151628 ^@ http://purl.uniprot.org/uniprot/G3R2M7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9595:PELI1 ^@ http://purl.uniprot.org/uniprot/G3RCA2 ^@ Function|||Similarity ^@ Belongs to the pellino family.|||E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. http://togogenome.org/gene/9595:LDHD ^@ http://purl.uniprot.org/uniprot/G3R505 ^@ Similarity ^@ Belongs to the FAD-binding oxidoreductase/transferase type 4 family. http://togogenome.org/gene/9595:ACP1 ^@ http://purl.uniprot.org/uniprot/G3RHR9|||http://purl.uniprot.org/uniprot/G3S306 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.|||Belongs to the low molecular weight phosphotyrosine protein phosphatase family.|||Cytoplasm http://togogenome.org/gene/9595:RAB3GAP2 ^@ http://purl.uniprot.org/uniprot/G3RS87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab3-GAP regulatory subunit family.|||Cytoplasm http://togogenome.org/gene/9595:EPCAM ^@ http://purl.uniprot.org/uniprot/G3SHA8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPCAM family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lateral cell membrane|||May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.|||Membrane|||tight junction http://togogenome.org/gene/9595:CHD1L ^@ http://purl.uniprot.org/uniprot/G3QFI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/9595:BCL9L ^@ http://purl.uniprot.org/uniprot/G3QYM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BCL9 family.|||Nucleus http://togogenome.org/gene/9595:STAT2 ^@ http://purl.uniprot.org/uniprot/G3RWV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:SLC6A12 ^@ http://purl.uniprot.org/uniprot/G3QX15 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Basolateral cell membrane|||Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily.|||Cell membrane|||Interacts with LIN7C.|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9595:TBC1D7 ^@ http://purl.uniprot.org/uniprot/A0A2I2YE76|||http://purl.uniprot.org/uniprot/G3QML5 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Vesicle http://togogenome.org/gene/9595:KCNS3 ^@ http://purl.uniprot.org/uniprot/G3QF91 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:CENPE ^@ http://purl.uniprot.org/uniprot/A0A2I2ZT31 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9595:PIGK ^@ http://purl.uniprot.org/uniprot/G3R1G4 ^@ Similarity|||Subunit ^@ Belongs to the peptidase C13 family.|||Forms a complex with PIGT, PIGS, PIGU and GAA1. http://togogenome.org/gene/9595:DUOX1 ^@ http://purl.uniprot.org/uniprot/G3R9G4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.|||In the N-terminal section; belongs to the peroxidase family.|||Membrane http://togogenome.org/gene/9595:DLGAP4 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZBH1|||http://purl.uniprot.org/uniprot/G3QRS7|||http://purl.uniprot.org/uniprot/G3QXA3 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/9595:ZNF397 ^@ http://purl.uniprot.org/uniprot/G3RPS0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:MTNR1A ^@ http://purl.uniprot.org/uniprot/G3R7Q0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.|||Membrane http://togogenome.org/gene/9595:MYBL2 ^@ http://purl.uniprot.org/uniprot/G3RMI6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:PIGV ^@ http://purl.uniprot.org/uniprot/G3QQK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGV family.|||Endoplasmic reticulum membrane|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.|||Membrane http://togogenome.org/gene/9595:MFSD11 ^@ http://purl.uniprot.org/uniprot/G3RRG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/9595:PICALM ^@ http://purl.uniprot.org/uniprot/A0A2I2ZKV2|||http://purl.uniprot.org/uniprot/G3SCQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PICALM/SNAP91 family.|||Membrane http://togogenome.org/gene/9595:ARL6 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z0Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||cilium membrane http://togogenome.org/gene/9595:CNTN2 ^@ http://purl.uniprot.org/uniprot/G3RFQ6 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. Contactin family. http://togogenome.org/gene/9595:LOC101128409 ^@ http://purl.uniprot.org/uniprot/G3R0G2 ^@ Similarity ^@ Belongs to the NXPE family. http://togogenome.org/gene/9595:ZC3H12D ^@ http://purl.uniprot.org/uniprot/G3QRX9 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/9595:ATP8B1 ^@ http://purl.uniprot.org/uniprot/G3RCJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9595:DPF3 ^@ http://purl.uniprot.org/uniprot/G3S544 ^@ Similarity ^@ Belongs to the requiem/DPF family. http://togogenome.org/gene/9595:GSTK1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y8N2|||http://purl.uniprot.org/uniprot/G3R8V8 ^@ Similarity ^@ Belongs to the GST superfamily. Kappa family. http://togogenome.org/gene/9595:LOC101148386 ^@ http://purl.uniprot.org/uniprot/G3QYN6 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9595:GADD45G ^@ http://purl.uniprot.org/uniprot/G3QQR8 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/9595:MAN2C1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZC02|||http://purl.uniprot.org/uniprot/G3RFT8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 38 family. http://togogenome.org/gene/9595:RGS5 ^@ http://purl.uniprot.org/uniprot/A0A2I2YCX4 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. http://togogenome.org/gene/9595:E2F4 ^@ http://purl.uniprot.org/uniprot/G3S5T4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9595:VAMP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1E0|||http://purl.uniprot.org/uniprot/G3QSL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9595:DOK4 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZYZ4|||http://purl.uniprot.org/uniprot/G3R9P0 ^@ Similarity ^@ Belongs to the DOK family. Type B subfamily. http://togogenome.org/gene/9595:MCM8 ^@ http://purl.uniprot.org/uniprot/G3S967 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Chromosome|||Nucleus http://togogenome.org/gene/9595:TMCO1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZQ86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMCO1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:TENT5C ^@ http://purl.uniprot.org/uniprot/A0A2I2YLA0 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/9595:SGCG ^@ http://purl.uniprot.org/uniprot/G3REE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/9595:TAP1 ^@ http://purl.uniprot.org/uniprot/G3R5U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.|||Membrane http://togogenome.org/gene/9595:METTL6 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1U9|||http://purl.uniprot.org/uniprot/G3RS32 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/9595:IDO1 ^@ http://purl.uniprot.org/uniprot/G3SJC1 ^@ Similarity ^@ Belongs to the indoleamine 2,3-dioxygenase family. http://togogenome.org/gene/9595:PHLDA3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZJ10 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:LDAF1 ^@ http://purl.uniprot.org/uniprot/G3R0N9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LDAF1 family.|||Endoplasmic reticulum membrane|||Lipid droplet|||Membrane http://togogenome.org/gene/9595:NAE1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YN42 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.|||Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. http://togogenome.org/gene/9595:NAA38 ^@ http://purl.uniprot.org/uniprot/A0A2I2YTV6 ^@ Function|||Similarity|||Subunit ^@ Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.|||Belongs to the snRNP Sm proteins family.|||Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30. http://togogenome.org/gene/9595:BZW1 ^@ http://purl.uniprot.org/uniprot/G3SA22 ^@ Similarity ^@ Belongs to the BZW family. http://togogenome.org/gene/9595:CXCL14 ^@ http://purl.uniprot.org/uniprot/G3QK30 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9595:NEK6 ^@ http://purl.uniprot.org/uniprot/G3R8Y7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:FLAD1 ^@ http://purl.uniprot.org/uniprot/G3RV92 ^@ Function|||Similarity ^@ Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.|||In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.|||In the N-terminal section; belongs to the MoaB/Mog family. http://togogenome.org/gene/9595:ACYP2 ^@ http://purl.uniprot.org/uniprot/G3R691 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/9595:CRX ^@ http://purl.uniprot.org/uniprot/G3RYT0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:CSF1R ^@ http://purl.uniprot.org/uniprot/G3RMC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:SMUG1 ^@ http://purl.uniprot.org/uniprot/G3QCU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.|||Nucleus http://togogenome.org/gene/9595:MED21 ^@ http://purl.uniprot.org/uniprot/G3RJL6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 21 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9595:CD2 ^@ http://purl.uniprot.org/uniprot/G3QRA4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:GLS2 ^@ http://purl.uniprot.org/uniprot/G3RKB6 ^@ Similarity ^@ Belongs to the glutaminase family. http://togogenome.org/gene/9595:EIF3D ^@ http://purl.uniprot.org/uniprot/G3RM58 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit D family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Cytoplasm|||Phosphorylated upon DNA damage, probably by ATM or ATR.|||The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.|||mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs. http://togogenome.org/gene/9595:MBOAT4 ^@ http://purl.uniprot.org/uniprot/G3QLI0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:LNPEP ^@ http://purl.uniprot.org/uniprot/A0A2I2ZXA2 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9595:PSEN2 ^@ http://purl.uniprot.org/uniprot/G3SCU1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A22A family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Homodimer.|||Membrane|||Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.|||The PAL motif is required for normal active site conformation. http://togogenome.org/gene/9595:LOC101142817 ^@ http://purl.uniprot.org/uniprot/G3SC01 ^@ Similarity ^@ Belongs to the pro/parathymosin family. http://togogenome.org/gene/9595:BHMT2 ^@ http://purl.uniprot.org/uniprot/G3QL14 ^@ Cofactor|||Function|||Subunit ^@ Binds 1 zinc ion per subunit.|||Homotetramer.|||Involved in the regulation of homocysteine metabolism. http://togogenome.org/gene/9595:MRPL22 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y3V1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/9595:PMP2 ^@ http://purl.uniprot.org/uniprot/G3RTZ8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||May play a role in lipid transport protein in Schwann cells. May bind cholesterol.|||Monomer. http://togogenome.org/gene/9595:ZDHHC22 ^@ http://purl.uniprot.org/uniprot/G3R3R5 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9595:MIEF2 ^@ http://purl.uniprot.org/uniprot/G3SF57 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9595:CMBL ^@ http://purl.uniprot.org/uniprot/G3RE16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dienelactone hydrolase family.|||cytosol http://togogenome.org/gene/9595:PATZ1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y7W2|||http://purl.uniprot.org/uniprot/A0A2I2ZTQ2|||http://purl.uniprot.org/uniprot/G3RLU7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:CATSPERE ^@ http://purl.uniprot.org/uniprot/G3QSJ2 ^@ Similarity ^@ Belongs to the CATSPERD family. http://togogenome.org/gene/9595:LOC101138570 ^@ http://purl.uniprot.org/uniprot/G3R0Z5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCO1/2 family.|||Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2.|||Homodimer.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:LOC101149517 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z5Y2|||http://purl.uniprot.org/uniprot/G3R4P4 ^@ Similarity|||Subunit ^@ Belongs to the GST superfamily. Theta family.|||Homodimer. http://togogenome.org/gene/9595:GPR137C ^@ http://purl.uniprot.org/uniprot/G3RE89 ^@ Subcellular Location Annotation ^@ Lysosome membrane|||Membrane http://togogenome.org/gene/9595:ATP6V1C1 ^@ http://purl.uniprot.org/uniprot/G3QNF3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits. http://togogenome.org/gene/9595:CRYZ ^@ http://purl.uniprot.org/uniprot/A0A2I2Y795|||http://purl.uniprot.org/uniprot/A0A2I2YE25 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/9595:PDE1B ^@ http://purl.uniprot.org/uniprot/A0A2I2ZYH9|||http://purl.uniprot.org/uniprot/G3QZ83 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9595:RPS6KB2 ^@ http://purl.uniprot.org/uniprot/G3R3D8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9595:DONSON ^@ http://purl.uniprot.org/uniprot/G3R9E4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DONSON family.|||Nucleus http://togogenome.org/gene/9595:C2BH2orf76 ^@ http://purl.uniprot.org/uniprot/G3QEX3 ^@ Similarity ^@ Belongs to the UPF0538 family. http://togogenome.org/gene/9595:LOC101151967 ^@ http://purl.uniprot.org/uniprot/G3RNK8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9595:OTUD7B ^@ http://purl.uniprot.org/uniprot/G3SI66 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9595:ZFHX2 ^@ http://purl.uniprot.org/uniprot/G3QQN8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:FBXO32 ^@ http://purl.uniprot.org/uniprot/G3QKF2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:IZUMO1 ^@ http://purl.uniprot.org/uniprot/G3QFY5 ^@ Similarity ^@ Belongs to the Izumo family. http://togogenome.org/gene/9595:AMBP ^@ http://purl.uniprot.org/uniprot/G3RE67 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Endoplasmic reticulum|||In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.|||Kunitz-type serine protease inhibitor. Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation. Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases.|||Membrane|||Mitochondrion inner membrane|||Monomer. Also occurs as a complex with tryptase in mast cells.|||Nucleus membrane|||cytosol|||extracellular matrix http://togogenome.org/gene/9595:STX5 ^@ http://purl.uniprot.org/uniprot/G3QHQ6 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9595:FAM76A ^@ http://purl.uniprot.org/uniprot/A0A2I2ZL12|||http://purl.uniprot.org/uniprot/A0A2I2ZME3 ^@ Similarity ^@ Belongs to the FAM76 family. http://togogenome.org/gene/9595:ARL6IP4 ^@ http://purl.uniprot.org/uniprot/A0A2I2YSV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARL6IP4 family.|||Nucleus speckle|||nucleolus http://togogenome.org/gene/9595:KCNA6 ^@ http://purl.uniprot.org/uniprot/A0A2I2YQ40 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:YIF1A ^@ http://purl.uniprot.org/uniprot/G3R2S9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIF1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Has a role in transport between endoplasmic reticulum and Golgi.|||Membrane http://togogenome.org/gene/9595:ATG101 ^@ http://purl.uniprot.org/uniprot/G3QU82 ^@ Similarity ^@ Belongs to the ATG101 family. http://togogenome.org/gene/9595:NID1 ^@ http://purl.uniprot.org/uniprot/G3SAI9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/9595:TSFM ^@ http://purl.uniprot.org/uniprot/G3QGE2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Mitochondrion http://togogenome.org/gene/9595:SLC22A4 ^@ http://purl.uniprot.org/uniprot/G3R4H4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Basal cell membrane|||Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.|||Cell membrane|||Interacts with PDZK1. http://togogenome.org/gene/9595:NIT1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z833 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. http://togogenome.org/gene/9595:LASP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YNI2|||http://purl.uniprot.org/uniprot/A0A2I2YUK1|||http://purl.uniprot.org/uniprot/G3QLF9 ^@ Function|||Subcellular Location Annotation ^@ Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.|||cell cortex|||cytoskeleton http://togogenome.org/gene/9595:VPS29 ^@ http://purl.uniprot.org/uniprot/A0A2I2YR60|||http://purl.uniprot.org/uniprot/G3QU67 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.|||Belongs to the VPS29 family.|||Endosome membrane http://togogenome.org/gene/9595:CSTF1 ^@ http://purl.uniprot.org/uniprot/G3QW97 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:TRAPPC6B ^@ http://purl.uniprot.org/uniprot/G3QCW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||cis-Golgi network http://togogenome.org/gene/9595:LOC101147097 ^@ http://purl.uniprot.org/uniprot/G3QKQ7 ^@ Similarity ^@ Belongs to the HPF1 family. http://togogenome.org/gene/9595:POLA2 ^@ http://purl.uniprot.org/uniprot/G3QKN0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.|||Belongs to the DNA polymerase alpha subunit B family.|||Nucleus http://togogenome.org/gene/9595:MAPRE3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z4P6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||cytoskeleton http://togogenome.org/gene/9595:TTYH2 ^@ http://purl.uniprot.org/uniprot/G3QET3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tweety family.|||Cell membrane|||Membrane|||Probable chloride channel. http://togogenome.org/gene/9595:MEF2A ^@ http://purl.uniprot.org/uniprot/A0A2I2YYW0|||http://purl.uniprot.org/uniprot/A0A2I2Z9B1|||http://purl.uniprot.org/uniprot/G3SD93 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:TTYH3 ^@ http://purl.uniprot.org/uniprot/G3QM48 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tweety family.|||Cell membrane|||Membrane|||Probable chloride channel. http://togogenome.org/gene/9595:PAQR7 ^@ http://purl.uniprot.org/uniprot/A0A2I2YCV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9595:RIPPLY3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YU60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ripply family.|||Nucleus http://togogenome.org/gene/9595:AGBL1 ^@ http://purl.uniprot.org/uniprot/G3SKW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||cytosol http://togogenome.org/gene/9595:IL3 ^@ http://purl.uniprot.org/uniprot/G3QFG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-3 family.|||Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB. Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program. Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK.|||Secreted http://togogenome.org/gene/9595:FRZB ^@ http://purl.uniprot.org/uniprot/G3QSJ7 ^@ Caution|||Function|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. http://togogenome.org/gene/9595:ARSJ ^@ http://purl.uniprot.org/uniprot/G3RAC0 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9595:MRPL20 ^@ http://purl.uniprot.org/uniprot/G3RU51|||http://purl.uniprot.org/uniprot/G3SDQ9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family. http://togogenome.org/gene/9595:PIGH ^@ http://purl.uniprot.org/uniprot/G3QGM9 ^@ Similarity ^@ Belongs to the PIGH family. http://togogenome.org/gene/9595:SPTBN2 ^@ http://purl.uniprot.org/uniprot/G3R7Q6 ^@ Similarity ^@ Belongs to the spectrin family. http://togogenome.org/gene/9595:GAL3ST3 ^@ http://purl.uniprot.org/uniprot/G3RUM1 ^@ Similarity ^@ Belongs to the galactose-3-O-sulfotransferase family. http://togogenome.org/gene/9595:NUF2 ^@ http://purl.uniprot.org/uniprot/G3QY78 ^@ Similarity ^@ Belongs to the NUF2 family. http://togogenome.org/gene/9595:BORA ^@ http://purl.uniprot.org/uniprot/G3QP94 ^@ Similarity ^@ Belongs to the BORA family. http://togogenome.org/gene/9595:TMEM225B ^@ http://purl.uniprot.org/uniprot/A0A2I2ZHR8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:BPGM ^@ http://purl.uniprot.org/uniprot/G3QX34 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/9595:GRIA3 ^@ http://purl.uniprot.org/uniprot/G3R2A6|||http://purl.uniprot.org/uniprot/G3SEM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9595:LDB1 ^@ http://purl.uniprot.org/uniprot/G3QIB3 ^@ Similarity ^@ Belongs to the LDB family. http://togogenome.org/gene/9595:RPL10A ^@ http://purl.uniprot.org/uniprot/G3RV13 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL1 family. http://togogenome.org/gene/9595:POLR2G ^@ http://purl.uniprot.org/uniprot/G3R7V2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.|||DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/9595:LOC101128980 ^@ http://purl.uniprot.org/uniprot/G3RSJ4 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9595:INSL6 ^@ http://purl.uniprot.org/uniprot/G3R094 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||May have a role in sperm development and fertilization.|||Secreted http://togogenome.org/gene/9595:IDH3A ^@ http://purl.uniprot.org/uniprot/G3QII7|||http://purl.uniprot.org/uniprot/G3SDQ5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.|||Mitochondrion http://togogenome.org/gene/9595:PORCN ^@ http://purl.uniprot.org/uniprot/A0A2I2Y799|||http://purl.uniprot.org/uniprot/A0A2I2YZS7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:SEH1L ^@ http://purl.uniprot.org/uniprot/G3R6H1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.|||Lysosome membrane|||kinetochore http://togogenome.org/gene/9595:EXOC7 ^@ http://purl.uniprot.org/uniprot/A0A2I2YQS2|||http://purl.uniprot.org/uniprot/A0A2I2ZTN5|||http://purl.uniprot.org/uniprot/G3RUS4 ^@ Function|||Similarity ^@ Belongs to the EXO70 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/9595:C8H8orf33 ^@ http://purl.uniprot.org/uniprot/G3RKS6 ^@ Similarity ^@ Belongs to the UPF0488 family. http://togogenome.org/gene/9595:CERCAM ^@ http://purl.uniprot.org/uniprot/G3QQP6 ^@ Similarity ^@ Belongs to the glycosyltransferase 25 family. http://togogenome.org/gene/9595:PRAF2 ^@ http://purl.uniprot.org/uniprot/G3QE86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/9595:ADGRA3 ^@ http://purl.uniprot.org/uniprot/G3SEX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Membrane http://togogenome.org/gene/9595:ATP23 ^@ http://purl.uniprot.org/uniprot/G3R572 ^@ Similarity ^@ Belongs to the peptidase M76 family. http://togogenome.org/gene/9595:STAT1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YUU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:LOC109023038 ^@ http://purl.uniprot.org/uniprot/G3RWW1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. http://togogenome.org/gene/9595:MAP7D2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YYQ9|||http://purl.uniprot.org/uniprot/G3QXP4 ^@ Similarity ^@ Belongs to the MAP7 family. http://togogenome.org/gene/9595:FOXN3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y453 ^@ Function|||Subcellular Location Annotation ^@ Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).|||Nucleus http://togogenome.org/gene/9595:POLR3H ^@ http://purl.uniprot.org/uniprot/A0A2I2ZTU2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/9595:LRRFIP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YZD3|||http://purl.uniprot.org/uniprot/G3QHD2 ^@ Similarity ^@ Belongs to the LRRFIP family. http://togogenome.org/gene/9595:LOC101153190 ^@ http://purl.uniprot.org/uniprot/G3RGS2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bZIP family.|||Homodimer; binds DNA as homodimer. Heterodimer; heterodimerizes with other members of ATF family and with JUN family members.|||Nucleus|||Stress-responsive chromatin regulator that plays a role in various biological processes including innate immunological memory, adipocyte differentiation or telomerase regulation. In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di-methyltransferases thus silencing the transcription of target genes such as STAT1 in adipocytes, or genes involved in innate immunity in macrophages and adipocytes. Stress induces ATF7 phosphorylation that disrupts interactions with histone methyltransferase and enhances the association with coactivators containing histone acetyltransferase and/or histone demethylase, leading to disruption of the heterochromatin-like structure and subsequently transcriptional activation. In response to TNF-alpha, which is induced by various stresses, phosphorylated ATF7 and telomerase are released from telomeres leading to telomere shortening. http://togogenome.org/gene/9595:SEC61G ^@ http://purl.uniprot.org/uniprot/G3QSU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecE/SEC61-gamma family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:SLC12A9 ^@ http://purl.uniprot.org/uniprot/G3QGM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9595:RAMP2 ^@ http://purl.uniprot.org/uniprot/G3QLL9 ^@ Similarity ^@ Belongs to the RAMP family. http://togogenome.org/gene/9595:ARR3 ^@ http://purl.uniprot.org/uniprot/G3QUR5 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9595:TGFA ^@ http://purl.uniprot.org/uniprot/A0A2I2ZBF2|||http://purl.uniprot.org/uniprot/A0A2I2ZCX9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:ACSS1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YQX6|||http://purl.uniprot.org/uniprot/G3QG16 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9595:IRF6 ^@ http://purl.uniprot.org/uniprot/A0A2I2YEL4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:PON1 ^@ http://purl.uniprot.org/uniprot/G3QPZ3 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit.|||Glycosylated. http://togogenome.org/gene/9595:THEMIS2 ^@ http://purl.uniprot.org/uniprot/G3R1E7 ^@ Similarity ^@ Belongs to the themis family. http://togogenome.org/gene/9595:FSCN3 ^@ http://purl.uniprot.org/uniprot/G3RKS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fascin family.|||cytoskeleton http://togogenome.org/gene/9595:DLL1 ^@ http://purl.uniprot.org/uniprot/G3QRX5 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/9595:PEAR1 ^@ http://purl.uniprot.org/uniprot/G3RDA5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:IFNB1 ^@ http://purl.uniprot.org/uniprot/G3RM24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9595:VAPA ^@ http://purl.uniprot.org/uniprot/G3QH36|||http://purl.uniprot.org/uniprot/G3SJ25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:TUFM ^@ http://purl.uniprot.org/uniprot/A0A2I2YVU5 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/9595:ZC2HC1C ^@ http://purl.uniprot.org/uniprot/G3SBR6 ^@ Similarity ^@ Belongs to the ZC2HC1 family. http://togogenome.org/gene/9595:ASPHD1 ^@ http://purl.uniprot.org/uniprot/G3RHW5 ^@ Similarity ^@ Belongs to the aspartyl/asparaginyl beta-hydroxylase family. http://togogenome.org/gene/9595:PNPLA4 ^@ http://purl.uniprot.org/uniprot/G3QRQ4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:PAPOLA ^@ http://purl.uniprot.org/uniprot/G3QTX2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the poly(A) polymerase family.|||Binds 2 magnesium ions. Also active with manganese.|||Nucleus|||Polymerase that creates the 3'-poly(A) tail of mRNA's. http://togogenome.org/gene/9595:MRPL11 ^@ http://purl.uniprot.org/uniprot/G3QG30 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL11 family. http://togogenome.org/gene/9595:POU4F2 ^@ http://purl.uniprot.org/uniprot/G3QHI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/9595:DCST2 ^@ http://purl.uniprot.org/uniprot/G3RDB7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:IL5RA ^@ http://purl.uniprot.org/uniprot/A0A2I2ZZ52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 5 subfamily.|||Membrane http://togogenome.org/gene/9595:PDE1A ^@ http://purl.uniprot.org/uniprot/A0A2I2YVR3|||http://purl.uniprot.org/uniprot/A0A2I2ZTQ4 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9595:ACTG1 ^@ http://purl.uniprot.org/uniprot/G3RDT6 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9595:RBPJ ^@ http://purl.uniprot.org/uniprot/A0A2I2Z7A3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Su(H) family.|||Nucleus http://togogenome.org/gene/9595:THUMPD3 ^@ http://purl.uniprot.org/uniprot/G3QEA2 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/9595:TRIM21 ^@ http://purl.uniprot.org/uniprot/G3QUH3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:NTF4 ^@ http://purl.uniprot.org/uniprot/G3QRG5 ^@ Similarity ^@ Belongs to the NGF-beta family. http://togogenome.org/gene/9595:MFSD14B ^@ http://purl.uniprot.org/uniprot/G3QZH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/9595:EPB41 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y6N1 ^@ Subcellular Location Annotation ^@ Nucleus|||cell cortex|||cytoskeleton http://togogenome.org/gene/9595:CD52 ^@ http://purl.uniprot.org/uniprot/G3QXI4 ^@ Function|||Subcellular Location Annotation ^@ May play a role in carrying and orienting carbohydrate, as well as having a more specific role.|||Membrane http://togogenome.org/gene/9595:PIK3C2B ^@ http://purl.uniprot.org/uniprot/G3QG89 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9595:FPGS ^@ http://purl.uniprot.org/uniprot/G3QF64 ^@ Cofactor|||Function|||Similarity ^@ A monovalent cation.|||Belongs to the folylpolyglutamate synthase family.|||Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. http://togogenome.org/gene/9595:TRH ^@ http://purl.uniprot.org/uniprot/A0A2I2YDN3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRH family.|||Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.|||Secreted http://togogenome.org/gene/9595:SRP9 ^@ http://purl.uniprot.org/uniprot/G3R7D5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP9 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.|||Cytoplasm http://togogenome.org/gene/9595:PRIMPOL ^@ http://purl.uniprot.org/uniprot/G3R887 ^@ Similarity ^@ Belongs to the eukaryotic-type primase small subunit family. http://togogenome.org/gene/9595:ECHDC2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z3F8 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9595:GGACT ^@ http://purl.uniprot.org/uniprot/A0A2I2Z8I1 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family.|||Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. http://togogenome.org/gene/9595:PPIB ^@ http://purl.uniprot.org/uniprot/G3R669 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9595:GFUS ^@ http://purl.uniprot.org/uniprot/G3QIY4 ^@ Function|||Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.|||Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. http://togogenome.org/gene/9595:IZUMO1R ^@ http://purl.uniprot.org/uniprot/G3RFV1 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/9595:CCR8 ^@ http://purl.uniprot.org/uniprot/G3QTG2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:DPY30 ^@ http://purl.uniprot.org/uniprot/A0A2I2YG65 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/9595:COG7 ^@ http://purl.uniprot.org/uniprot/G3QGR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG7 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:UBE2I ^@ http://purl.uniprot.org/uniprot/A0A2I2YHE1 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9595:PRKN ^@ http://purl.uniprot.org/uniprot/A0A2I2YTU5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RBR family. Parkin subfamily.|||Forms an E3 ubiquitin ligase complex.|||Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.|||Mitochondrion|||cytosol http://togogenome.org/gene/9595:JPH1 ^@ http://purl.uniprot.org/uniprot/G3QK17 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the junctophilin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.|||Membrane http://togogenome.org/gene/9595:LOC101136992 ^@ http://purl.uniprot.org/uniprot/A0A2I2YS64 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative pheromone receptor. http://togogenome.org/gene/9595:ADI1 ^@ http://purl.uniprot.org/uniprot/G3SKI3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acireductone dioxygenase (ARD) family.|||Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.|||Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Also down-regulates cell migration mediated by MMP14.|||Cell membrane|||Cytoplasm|||Monomer. Interacts with MMP14.|||Nucleus http://togogenome.org/gene/9595:LAP3 ^@ http://purl.uniprot.org/uniprot/G3QFL8 ^@ Similarity|||Subunit ^@ Belongs to the peptidase M17 family.|||Homohexamer. http://togogenome.org/gene/9595:HIKESHI ^@ http://purl.uniprot.org/uniprot/G3SJD7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.|||Belongs to the OPI10 family.|||Cytoplasm|||Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.|||Nucleus|||cytosol http://togogenome.org/gene/9595:PTPRG ^@ http://purl.uniprot.org/uniprot/G3QVF1|||http://purl.uniprot.org/uniprot/G3SI67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.|||Membrane http://togogenome.org/gene/9595:DNAAF4 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZXF6|||http://purl.uniprot.org/uniprot/G3QRQ2|||http://purl.uniprot.org/uniprot/Q863A5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Dynein axonemal particle|||Interacts with ZMYND10 (By similarity). Interacts with STUB1 (By similarity). Interacts with ESR1 and ESR2. Interacts with DNAAF2 (By similarity). Interacts with CCT3, CCT4, CCT5 and CCT8 (By similarity). Interacts with DNAAF6/PIH1D3 (By similarity).|||Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity. Axonemal dynein assembly factor required for ciliary motility (By similarity).|||Nucleus|||neuron projection http://togogenome.org/gene/9595:SMG7 ^@ http://purl.uniprot.org/uniprot/G3RYM6 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Plays a role in nonsense-mediated mRNA decay. http://togogenome.org/gene/9595:GSG1L2 ^@ http://purl.uniprot.org/uniprot/G3QZL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSG1 family.|||Membrane http://togogenome.org/gene/9595:TRAPPC3 ^@ http://purl.uniprot.org/uniprot/G3QPZ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||Homodimer.|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||cis-Golgi network http://togogenome.org/gene/9595:CD1B ^@ http://purl.uniprot.org/uniprot/G3QRI4 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9595:RP2 ^@ http://purl.uniprot.org/uniprot/G3QUR9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.|||Belongs to the TBCC family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:LOC101149550 ^@ http://purl.uniprot.org/uniprot/G3QX78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:NLRP8 ^@ http://purl.uniprot.org/uniprot/G3QK83 ^@ Similarity ^@ Belongs to the NLRP family. http://togogenome.org/gene/9595:C11H11orf68 ^@ http://purl.uniprot.org/uniprot/G3QQ36 ^@ Similarity ^@ Belongs to the UPF0696 family. http://togogenome.org/gene/9595:CROT ^@ http://purl.uniprot.org/uniprot/G3RST5 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/9595:GALNT5 ^@ http://purl.uniprot.org/uniprot/G3QJ54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:PEX1 ^@ http://purl.uniprot.org/uniprot/G3QQV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||cytosol http://togogenome.org/gene/9595:WASF3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZQA9|||http://purl.uniprot.org/uniprot/G3R9W4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCAR/WAVE family.|||Binds actin and the Arp2/3 complex.|||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|||cytoskeleton http://togogenome.org/gene/9595:ACTR3 ^@ http://purl.uniprot.org/uniprot/G3SCF3 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9595:TRPV4 ^@ http://purl.uniprot.org/uniprot/G3QPN3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:LOC101134802 ^@ http://purl.uniprot.org/uniprot/G3RJC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9595:CHRNB4 ^@ http://purl.uniprot.org/uniprot/G3R4J9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9595:CP ^@ http://purl.uniprot.org/uniprot/G3RY85 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/9595:LPIN1 ^@ http://purl.uniprot.org/uniprot/G3QSY1 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/9595:STX10 ^@ http://purl.uniprot.org/uniprot/G3R225 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Golgi apparatus membrane http://togogenome.org/gene/9595:SYCE1 ^@ http://purl.uniprot.org/uniprot/G3QLD7 ^@ Similarity ^@ Belongs to the SYCE family. http://togogenome.org/gene/9595:NUTM1 ^@ http://purl.uniprot.org/uniprot/G3QXF0|||http://purl.uniprot.org/uniprot/G3RUC8 ^@ Similarity ^@ Belongs to the NUT family. http://togogenome.org/gene/9595:ADAM22 ^@ http://purl.uniprot.org/uniprot/A0A2I2YXV8|||http://purl.uniprot.org/uniprot/G3QI27 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:TNKS2 ^@ http://purl.uniprot.org/uniprot/G3R2V0 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9595:CCDC149 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZYS2|||http://purl.uniprot.org/uniprot/G3R3U2 ^@ Similarity ^@ Belongs to the CCDC149 family. http://togogenome.org/gene/9595:SFXN1 ^@ http://purl.uniprot.org/uniprot/G3QYR9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9595:LOC101136583 ^@ http://purl.uniprot.org/uniprot/G3RBT2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9595:SYNDIG1L ^@ http://purl.uniprot.org/uniprot/G3R0A6 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9595:SRRT ^@ http://purl.uniprot.org/uniprot/G3QGN2 ^@ Similarity ^@ Belongs to the ARS2 family. http://togogenome.org/gene/9595:FAM83C ^@ http://purl.uniprot.org/uniprot/G3R8T6 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9595:SENP3 ^@ http://purl.uniprot.org/uniprot/G3R7B9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C48 family.|||nucleolus http://togogenome.org/gene/9595:NDUFS2 ^@ http://purl.uniprot.org/uniprot/Q0MQG4 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 49 kDa subunit family.|||Binds 1 [4Fe-4S] cluster.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Component of the iron-sulfur (IP) fragment of the enzyme. Interacts with NDUFAF3. Interacts with NDUFAF7 (By similarity). Interacts with CERS2 (By similarity).|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (By similarity). Essential for the catalytic activity and assembly of complex I (By similarity). Redox-sensitive, critical component of the oxygen-sensing pathway in the pulmonary vasculature which plays a key role in acute pulmonary oxygen-sensing and hypoxic pulmonary vasoconstriction (By similarity). Plays an important role in carotid body sensing of hypoxia (By similarity). Essential for glia-like neural stem and progenitor cell proliferation, differentiation and subsequent oligodendrocyte or neuronal maturation (By similarity).|||Dimethylation at Arg-118 by NDUFAF7 takes place after NDUFS2 assembles into the complex I, leading to stabilize the early intermediate complex.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:FUT11 ^@ http://purl.uniprot.org/uniprot/G3QTL7|||http://purl.uniprot.org/uniprot/G3RPS2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Membrane|||Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. http://togogenome.org/gene/9595:LOC101128005 ^@ http://purl.uniprot.org/uniprot/G3RHE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9595:LXN ^@ http://purl.uniprot.org/uniprot/G3QKQ9 ^@ Similarity ^@ Belongs to the protease inhibitor I47 (latexin) family. http://togogenome.org/gene/9595:RIDA ^@ http://purl.uniprot.org/uniprot/G3QFT9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RutC family.|||Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.|||Peroxisome http://togogenome.org/gene/9595:DNAAF1 ^@ http://purl.uniprot.org/uniprot/G3RM43 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNAAF1 family.|||Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli.|||cilium http://togogenome.org/gene/9595:SPO11 ^@ http://purl.uniprot.org/uniprot/A0A2I2YML3|||http://purl.uniprot.org/uniprot/G3R0G7 ^@ Similarity ^@ Belongs to the TOP6A family. http://togogenome.org/gene/9595:GRPR ^@ http://purl.uniprot.org/uniprot/G3RL33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:TRAF6 ^@ http://purl.uniprot.org/uniprot/G3QST5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family. A subfamily.|||Lipid droplet|||Nucleus|||cell cortex http://togogenome.org/gene/9595:ANKRD34A ^@ http://purl.uniprot.org/uniprot/A0A2I2YNF1 ^@ Similarity ^@ Belongs to the ANKRD34 family. http://togogenome.org/gene/9595:LPAR3 ^@ http://purl.uniprot.org/uniprot/G3R648 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:SPATA18 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZD49|||http://purl.uniprot.org/uniprot/G3QZJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIEAP family.|||Cytoplasm|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9595:LOC101130686 ^@ http://purl.uniprot.org/uniprot/G3RWS7 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.|||Belongs to the universal ribosomal protein uS2 family.|||Cell membrane|||Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.|||Cytoplasm|||Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.|||Nucleus|||Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.|||This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. http://togogenome.org/gene/9595:ATP6V0D1 ^@ http://purl.uniprot.org/uniprot/G3RB21 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9595:HNF1B ^@ http://purl.uniprot.org/uniprot/A0A2I2Z4H1|||http://purl.uniprot.org/uniprot/G3S805 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HNF1 homeobox family.|||Nucleus http://togogenome.org/gene/9595:MTCP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZHP0 ^@ Similarity ^@ Belongs to the TCL1 family. http://togogenome.org/gene/9595:LOC101152596 ^@ http://purl.uniprot.org/uniprot/G3REX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX16 family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9595:TBC1D31 ^@ http://purl.uniprot.org/uniprot/G3R1F4|||http://purl.uniprot.org/uniprot/G3S530 ^@ Function|||Subcellular Location Annotation ^@ Molecular adapter which is involved in cilium biogenesis. Part of a functional complex including OFD1 a centriolar protein involved in cilium assembly. Could regulate the cAMP-dependent phosphorylation of OFD1, and its subsequent ubiquitination by PJA2 which ultimately leads to its proteasomal degradation.|||centriolar satellite|||cilium basal body http://togogenome.org/gene/9595:TMEM233 ^@ http://purl.uniprot.org/uniprot/G3RZD9 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9595:GADL1 ^@ http://purl.uniprot.org/uniprot/G3QCW3 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9595:CENPQ ^@ http://purl.uniprot.org/uniprot/G3RW50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-Q/OKP1 family.|||Nucleus http://togogenome.org/gene/9595:LRRFIP1 ^@ http://purl.uniprot.org/uniprot/G3QZC0 ^@ Similarity ^@ Belongs to the LRRFIP family. http://togogenome.org/gene/9595:CDIP1 ^@ http://purl.uniprot.org/uniprot/G3S7S4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/9595:ELOA ^@ http://purl.uniprot.org/uniprot/G3RGB1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:NARF ^@ http://purl.uniprot.org/uniprot/A0A2I2ZGA6 ^@ Similarity ^@ Belongs to the NARF family. http://togogenome.org/gene/9595:TMEM88 ^@ http://purl.uniprot.org/uniprot/G3RH25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM88 family.|||Membrane http://togogenome.org/gene/9595:SUDS3 ^@ http://purl.uniprot.org/uniprot/G3R5Z9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:CSMD3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZUL6|||http://purl.uniprot.org/uniprot/G3QU22 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:FAM20A ^@ http://purl.uniprot.org/uniprot/G3QKR8 ^@ Similarity ^@ Belongs to the FAM20 family. http://togogenome.org/gene/9595:ARHGAP26 ^@ http://purl.uniprot.org/uniprot/G3QVT9 ^@ Subcellular Location Annotation ^@ cytoskeleton|||focal adhesion http://togogenome.org/gene/9595:NDUFS6 ^@ http://purl.uniprot.org/uniprot/Q0MQH6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS6 subunit family.|||Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:PSMB5 ^@ http://purl.uniprot.org/uniprot/G3S725 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:LOC101138998 ^@ http://purl.uniprot.org/uniprot/G3RRI4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the hcp beta-lactamase family.|||Mitochondrion intermembrane space|||Required for assembly of mitochondrial respiratory chain complexes. http://togogenome.org/gene/9595:LOC101124683 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZKV1|||http://purl.uniprot.org/uniprot/A0A2I2ZNA6|||http://purl.uniprot.org/uniprot/G3S5X7 ^@ Similarity ^@ Belongs to the RRM HNRPC family. RALY subfamily. http://togogenome.org/gene/9595:PRKRA ^@ http://purl.uniprot.org/uniprot/G3QSJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRKRA family.|||perinuclear region http://togogenome.org/gene/9595:GPSM2 ^@ http://purl.uniprot.org/uniprot/G3QPV4 ^@ Similarity ^@ Belongs to the GPSM family. http://togogenome.org/gene/9595:LOC101132985 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZDI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:MTR ^@ http://purl.uniprot.org/uniprot/G3RTZ4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vitamin-B12 dependent methionine synthase family.|||Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.|||Cytoplasm|||Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin. http://togogenome.org/gene/9595:STARD3 ^@ http://purl.uniprot.org/uniprot/G3QW10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STARD3 family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9595:CFC1B ^@ http://purl.uniprot.org/uniprot/G3SED3 ^@ Caution|||Similarity ^@ Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:ALDH18A1 ^@ http://purl.uniprot.org/uniprot/G3R9U3 ^@ Similarity ^@ In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.|||In the N-terminal section; belongs to the glutamate 5-kinase family. http://togogenome.org/gene/9595:TMEM176A ^@ http://purl.uniprot.org/uniprot/A0A2I2ZV82 ^@ Similarity ^@ Belongs to the TMEM176 family. http://togogenome.org/gene/9595:LYRM9 ^@ http://purl.uniprot.org/uniprot/A0A2I2YAL9|||http://purl.uniprot.org/uniprot/G3QS33 ^@ Similarity ^@ Belongs to the complex I LYR family. LYRM9 subfamily. http://togogenome.org/gene/9595:ATG3 ^@ http://purl.uniprot.org/uniprot/G3QUT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG3 family.|||Cytoplasm http://togogenome.org/gene/9595:LIM2 ^@ http://purl.uniprot.org/uniprot/G3RFP4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis. http://togogenome.org/gene/9595:ZMPSTE24 ^@ http://purl.uniprot.org/uniprot/G3SDX9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48A family.|||Binds 1 zinc ion per subunit.|||Endoplasmic reticulum membrane|||Proteolytically removes the C-terminal three residues of farnesylated proteins. http://togogenome.org/gene/9595:MRPL30 ^@ http://purl.uniprot.org/uniprot/A0A2I2YL41 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/9595:ALDH3A1 ^@ http://purl.uniprot.org/uniprot/G3S7E9 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9595:FMO5 ^@ http://purl.uniprot.org/uniprot/G3S9Y3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters.|||Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9595:SIRT4 ^@ http://purl.uniprot.org/uniprot/G3SBZ3 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ According to some authors, ADP-ribosyltransferase activity of sirtuins may be an inefficient side reaction of the deacetylase activity and may not be physiologically relevant.|||Acts as NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Does not seem to deacetylate PC. Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels. Down-regulates insulin secretion.|||Belongs to the sirtuin family. Class II subfamily.|||Binds 1 zinc ion per subunit.|||Interacts with GLUD1, IDE and SLC25A5. Interacts with DLAT and PDHX.|||Mitochondrion matrix http://togogenome.org/gene/9595:INHBA ^@ http://purl.uniprot.org/uniprot/A0A2I2ZMR9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/9595:MTCH2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YWI5|||http://purl.uniprot.org/uniprot/G3QYZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9595:SOX14 ^@ http://purl.uniprot.org/uniprot/G3RDD2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SNW1 ^@ http://purl.uniprot.org/uniprot/G3S3X9|||http://purl.uniprot.org/uniprot/G3SJU5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNW family.|||Identified in the spliceosome C complex.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/9595:RNF182 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y7J3 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with ATP6V0C.|||Membrane http://togogenome.org/gene/9595:MARK2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y6Q3|||http://purl.uniprot.org/uniprot/A0A2I2ZW92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||dendrite http://togogenome.org/gene/9595:MAOB ^@ http://purl.uniprot.org/uniprot/G3QD91 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/9595:KIF2B ^@ http://purl.uniprot.org/uniprot/G3QVK2 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9595:TASOR ^@ http://purl.uniprot.org/uniprot/A0A2I2YW35|||http://purl.uniprot.org/uniprot/G3R6V4 ^@ Similarity ^@ Belongs to the TASOR family. http://togogenome.org/gene/9595:ADK ^@ http://purl.uniprot.org/uniprot/A0A2I2YPI6|||http://purl.uniprot.org/uniprot/G3QRM8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.|||Belongs to the carbohydrate kinase PfkB family.|||Binds 3 Mg(2+) ions per subunit.|||Monomer.|||Nucleus http://togogenome.org/gene/9595:NDUFB5 ^@ http://purl.uniprot.org/uniprot/A0A2I2YPV4|||http://purl.uniprot.org/uniprot/A0A2I2ZAF4|||http://purl.uniprot.org/uniprot/Q0MQD7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB5 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:CHST2 ^@ http://purl.uniprot.org/uniprot/G3R5W4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/9595:INTS14 ^@ http://purl.uniprot.org/uniprot/A0A2I2YSE8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INTS14 family.|||Nucleus|||Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. http://togogenome.org/gene/9595:FOXJ3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YRH3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:EIF3F ^@ http://purl.uniprot.org/uniprot/G3SER3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit F family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm|||Phosphorylated. Phosphorylation is enhanced upon serum stimulation. http://togogenome.org/gene/9595:ITM2A ^@ http://purl.uniprot.org/uniprot/G3RPS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITM2 family.|||Membrane http://togogenome.org/gene/9595:CWC15 ^@ http://purl.uniprot.org/uniprot/G3R8D2 ^@ Similarity ^@ Belongs to the CWC15 family. http://togogenome.org/gene/9595:LOC101151025 ^@ http://purl.uniprot.org/uniprot/G3SG11 ^@ Subcellular Location Annotation|||Subunit ^@ Membrane|||The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta. http://togogenome.org/gene/9595:LAMA4 ^@ http://purl.uniprot.org/uniprot/G3RGA8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/9595:HDAC3 ^@ http://purl.uniprot.org/uniprot/G3RJT0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.|||Nucleus http://togogenome.org/gene/9595:GALR2 ^@ http://purl.uniprot.org/uniprot/G3R0C9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9595:GSS ^@ http://purl.uniprot.org/uniprot/G3QVM8 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic GSH synthase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/9595:CACNB2 ^@ http://purl.uniprot.org/uniprot/G3SGK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||sarcolemma http://togogenome.org/gene/9595:TNFSF13 ^@ http://purl.uniprot.org/uniprot/G3R7B3|||http://purl.uniprot.org/uniprot/G3S155 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9595:GIMAP8 ^@ http://purl.uniprot.org/uniprot/G3S4T9 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9595:CLN8 ^@ http://purl.uniprot.org/uniprot/A0A2I2YDC0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:IL4R ^@ http://purl.uniprot.org/uniprot/G3QKJ7 ^@ Function|||Similarity ^@ Belongs to the type I cytokine receptor family. Type 4 subfamily.|||Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. http://togogenome.org/gene/9595:CLCA1 ^@ http://purl.uniprot.org/uniprot/G3R7X0 ^@ Similarity ^@ Belongs to the CLCR family. http://togogenome.org/gene/9595:MOCS1 ^@ http://purl.uniprot.org/uniprot/G3R0Q1 ^@ Similarity ^@ In the C-terminal section; belongs to the MoaC family.|||In the N-terminal section; belongs to the radical SAM superfamily. MoaA family. http://togogenome.org/gene/9595:IPPK ^@ http://purl.uniprot.org/uniprot/G3QMV0 ^@ Domain|||Function|||Similarity ^@ Belongs to the IPK1 type 2 family.|||Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).|||The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2. http://togogenome.org/gene/9595:TUBB6 ^@ http://purl.uniprot.org/uniprot/A0A2I2YTU3|||http://purl.uniprot.org/uniprot/G3QLA2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9595:GRHL3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZI75|||http://purl.uniprot.org/uniprot/G3SJB7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:B3GNT7 ^@ http://purl.uniprot.org/uniprot/G3R4F6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:RNF185 ^@ http://purl.uniprot.org/uniprot/G3S997 ^@ Domain|||Function|||Subcellular Location Annotation ^@ E3 ubiquitin-protein ligase.|||Endoplasmic reticulum membrane|||Mitochondrion membrane|||The RING-type zinc finger domain is responsible for E3 ligase activity. http://togogenome.org/gene/9595:TBK1 ^@ http://purl.uniprot.org/uniprot/G3S8G6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:GNGT2 ^@ http://purl.uniprot.org/uniprot/G3QHT5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9595:TASP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y4V4 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/9595:TMEM45B ^@ http://purl.uniprot.org/uniprot/G3S4Q9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/9595:PON2 ^@ http://purl.uniprot.org/uniprot/G3RXU5 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit.|||Glycosylated. http://togogenome.org/gene/9595:ARRB1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZB40|||http://purl.uniprot.org/uniprot/G3R2M1 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9595:CAP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZQK8|||http://purl.uniprot.org/uniprot/G3SA10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAP family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:AMOTL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y6D1|||http://purl.uniprot.org/uniprot/G3RXQ2 ^@ Similarity ^@ Belongs to the angiomotin family. http://togogenome.org/gene/9595:OPLAH ^@ http://purl.uniprot.org/uniprot/G3RIV3 ^@ Similarity ^@ Belongs to the oxoprolinase family. http://togogenome.org/gene/9595:NAGLU ^@ http://purl.uniprot.org/uniprot/G3R5I9 ^@ Subcellular Location Annotation ^@ Lysosome http://togogenome.org/gene/9595:INS ^@ http://purl.uniprot.org/uniprot/Q6YK33 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the insulin family.|||Heterodimer of a B chain and an A chain linked by two disulfide bonds.|||Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.|||Secreted http://togogenome.org/gene/9595:ANK2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y5T8|||http://purl.uniprot.org/uniprot/G3S4C5 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/9595:ASXL2 ^@ http://purl.uniprot.org/uniprot/G3R5Z8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Asx family.|||Nucleus http://togogenome.org/gene/9595:EVX2 ^@ http://purl.uniprot.org/uniprot/G3S455 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:CD320 ^@ http://purl.uniprot.org/uniprot/G3QF47 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:SLC1A2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y9Z5|||http://purl.uniprot.org/uniprot/A0A2I2ZRF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9595:CXCL10 ^@ http://purl.uniprot.org/uniprot/G3R4U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9595:LRRC51 ^@ http://purl.uniprot.org/uniprot/A0A2I2YY39|||http://purl.uniprot.org/uniprot/A0A2I2ZB38 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:SLC25A36 ^@ http://purl.uniprot.org/uniprot/G3SAY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9595:ADA2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YCW0|||http://purl.uniprot.org/uniprot/G3QXR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.|||Secreted http://togogenome.org/gene/9595:IL4 ^@ http://purl.uniprot.org/uniprot/G3QSC0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-4/IL-13 family.|||Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.|||Secreted http://togogenome.org/gene/9595:CEP162 ^@ http://purl.uniprot.org/uniprot/G3QWH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP162 family.|||centriole http://togogenome.org/gene/9595:TMED4 ^@ http://purl.uniprot.org/uniprot/G3R8N7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:ZNF174 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y8Q0|||http://purl.uniprot.org/uniprot/G3RJY5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:IRX3 ^@ http://purl.uniprot.org/uniprot/G3RDV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/IRO homeobox family.|||Nucleus http://togogenome.org/gene/9595:P2RY2 ^@ http://purl.uniprot.org/uniprot/G3RAV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:TSR2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YKB2 ^@ Function|||Similarity ^@ Belongs to the TSR2 family.|||May be involved in 20S pre-rRNA processing. http://togogenome.org/gene/9595:LCE3B ^@ http://purl.uniprot.org/uniprot/G3QIF5 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9595:ALKBH2 ^@ http://purl.uniprot.org/uniprot/G3RZ41 ^@ Similarity ^@ Belongs to the alkB family. http://togogenome.org/gene/9595:SGCA ^@ http://purl.uniprot.org/uniprot/G3RBL8 ^@ Function|||Similarity ^@ Belongs to the sarcoglycan alpha/epsilon family.|||Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. http://togogenome.org/gene/9595:CHMP4C ^@ http://purl.uniprot.org/uniprot/G3RKJ9 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9595:TYROBP ^@ http://purl.uniprot.org/uniprot/G3RH46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TYROBP family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:PFDN1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZB60 ^@ Function|||Similarity ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. http://togogenome.org/gene/9595:TMEM254 ^@ http://purl.uniprot.org/uniprot/G3RTF8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:SCARB2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y3T2 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/9595:TAS1R2 ^@ http://purl.uniprot.org/uniprot/G3QS00 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:NLK ^@ http://purl.uniprot.org/uniprot/G3S5N7 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9595:ABL1 ^@ http://purl.uniprot.org/uniprot/G3R4W2|||http://purl.uniprot.org/uniprot/G3RSE2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9595:INTS9 ^@ http://purl.uniprot.org/uniprot/G3SJ43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.|||Nucleus http://togogenome.org/gene/9595:ST6GALNAC2 ^@ http://purl.uniprot.org/uniprot/G3R968 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9595:STAB1 ^@ http://purl.uniprot.org/uniprot/G3RM17 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:AKAP4 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZY16|||http://purl.uniprot.org/uniprot/G3RJC1 ^@ Similarity ^@ Belongs to the AKAP110 family. http://togogenome.org/gene/9595:ROPN1B ^@ http://purl.uniprot.org/uniprot/G3QVB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ropporin family.|||flagellum http://togogenome.org/gene/9595:MED24 ^@ http://purl.uniprot.org/uniprot/G3QQT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 24 family.|||Nucleus http://togogenome.org/gene/9595:CHRDL1 ^@ http://purl.uniprot.org/uniprot/G3QJ73 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9595:PARP10 ^@ http://purl.uniprot.org/uniprot/G3QHE9 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9595:LOC101130739 ^@ http://purl.uniprot.org/uniprot/G3RH94 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/9595:CNDP2 ^@ http://purl.uniprot.org/uniprot/G3RKV3 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20A family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9595:DLX2 ^@ http://purl.uniprot.org/uniprot/G3QRE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus http://togogenome.org/gene/9595:GLIPR1 ^@ http://purl.uniprot.org/uniprot/G3RCM0 ^@ Similarity ^@ Belongs to the CRISP family. http://togogenome.org/gene/9595:B3GAT3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YF45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:VPS36 ^@ http://purl.uniprot.org/uniprot/G3QYH7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VPS36 family.|||Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II).|||Cytoplasm|||Endosome http://togogenome.org/gene/9595:SMPDL3B ^@ http://purl.uniprot.org/uniprot/G3RG15 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acid sphingomyelinase family.|||Binds 2 Zn(2+) per subunit.|||Secreted http://togogenome.org/gene/9595:MDM2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZWM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM2/MDM4 family.|||Cytoplasm|||nucleolus|||nucleoplasm http://togogenome.org/gene/9595:NPBWR2 ^@ http://purl.uniprot.org/uniprot/G3QHJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:LOC101151886 ^@ http://purl.uniprot.org/uniprot/G3QRJ6 ^@ Similarity ^@ Belongs to the CD200R family. http://togogenome.org/gene/9595:GPR156 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y5H2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:UBB ^@ http://purl.uniprot.org/uniprot/P0CG67 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ubiquitin family.|||Cytoplasm|||Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.|||For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains.|||Interacts with SKP1-KMD2A and SKP1-KMD2B complexes.|||Mitochondrion outer membrane|||Mono-ADP-ribosylated at the C-terminus by PARP9, a component of the PPAR9-DTX3L complex. ADP-ribosylation requires processing by E1 and E2 enzymes and prevents ubiquitin conjugation to substrates such as histones.|||Nucleus|||Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PRKN), triggering mitophagy. Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30.|||Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins eL40 and eS31, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains. http://togogenome.org/gene/9595:LOC101125649 ^@ http://purl.uniprot.org/uniprot/A0A2I2YP41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:LOC101151331 ^@ http://purl.uniprot.org/uniprot/G3QHX6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MHC class I family.|||Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).|||Involved in the presentation of foreign antigens to the immune system. http://togogenome.org/gene/9595:S100A4 ^@ http://purl.uniprot.org/uniprot/G3QWC6 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9595:LOC101146547 ^@ http://purl.uniprot.org/uniprot/G3RJ46 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SLC26A4 ^@ http://purl.uniprot.org/uniprot/G3SKH5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane|||Sodium-independent transporter of chloride and iodide. http://togogenome.org/gene/9595:EIF2S1 ^@ http://purl.uniprot.org/uniprot/G3QGW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-2-alpha family.|||Stress granule http://togogenome.org/gene/9595:NPR2 ^@ http://purl.uniprot.org/uniprot/G3R6K8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane http://togogenome.org/gene/9595:TNMD ^@ http://purl.uniprot.org/uniprot/G3RLF4 ^@ Similarity ^@ Belongs to the chondromodulin-1 family. http://togogenome.org/gene/9595:PPIA ^@ http://purl.uniprot.org/uniprot/Q0ZQL0 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization (By similarity). PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition (By similarity). Acetylation at Lys-125 favors the interaction with TARDBP (By similarity).|||Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.|||Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.|||Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity).|||Cytoplasm|||Interacts with protein phosphatase PPP3CA/calcineurin A (By similarity). Interacts with isoform 2 of BSG/CD147 (By similarity). Interacts with FOXO1; the interaction promotes FOXO1 dephosphorylation, nuclear accumulation and transcriptional activity (By similarity). Interacts with integrin ITGA2B:ITGB3; the interaction is ROS and peptidyl-prolyl cis-trans isomerase (PPIase) activity-dependent and is increased in the presence of thrombin (By similarity). Interacts with MAP3K5 (By similarity). Interacts with TARDBP; the interaction is dependent on the RNA-binding activity of TARDBP and the PPIase activity of PPIA/CYPA and the acetylation of PPIA/CYPA at Lys-125 favors the interaction (By similarity). Interacts with HNRNPA1, HNRNPA2B1, HNRNPC, RBMX, HNRNPK and HNRNPM (By similarity).|||Nucleus|||Secreted http://togogenome.org/gene/9595:UBA3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZDY8|||http://purl.uniprot.org/uniprot/G3QMY7 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.|||Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8. http://togogenome.org/gene/9595:IMPG2 ^@ http://purl.uniprot.org/uniprot/G3RJ49 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||interphotoreceptor matrix http://togogenome.org/gene/9595:VIPAS39 ^@ http://purl.uniprot.org/uniprot/G3RK70 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Early endosome|||Endosome|||Late endosome|||Vesicle http://togogenome.org/gene/9595:EXOC3L4 ^@ http://purl.uniprot.org/uniprot/G3RKM6 ^@ Similarity ^@ Belongs to the SEC6 family. http://togogenome.org/gene/9595:AGA ^@ http://purl.uniprot.org/uniprot/G3QX96 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/9595:POFUT1 ^@ http://purl.uniprot.org/uniprot/G3RAS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 65 family.|||Endoplasmic reticulum http://togogenome.org/gene/9595:DLL4 ^@ http://purl.uniprot.org/uniprot/G3SK70 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/9595:SDHAF3 ^@ http://purl.uniprot.org/uniprot/G3RFT5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I LYR family. SDHAF3 subfamily.|||Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.|||Mitochondrion matrix|||Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1. http://togogenome.org/gene/9595:SLFN11 ^@ http://purl.uniprot.org/uniprot/G3SKH2 ^@ Similarity ^@ Belongs to the Schlafen family. Subgroup III subfamily. http://togogenome.org/gene/9595:GPM6B ^@ http://purl.uniprot.org/uniprot/A0A2I2Y331|||http://purl.uniprot.org/uniprot/A0A2I2YQZ7|||http://purl.uniprot.org/uniprot/G3REG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/9595:SCFD1 ^@ http://purl.uniprot.org/uniprot/G3R600 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9595:ST13 ^@ http://purl.uniprot.org/uniprot/G3S180 ^@ Similarity ^@ Belongs to the FAM10 family. http://togogenome.org/gene/9595:DYNLL2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZQA7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.|||Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/9595:C1H1orf74 ^@ http://purl.uniprot.org/uniprot/G3QTP0 ^@ Similarity ^@ Belongs to the UPF0739 family. http://togogenome.org/gene/9595:TSN ^@ http://purl.uniprot.org/uniprot/G3QIH4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the translin family.|||DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.|||Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.|||Nucleus|||Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring. http://togogenome.org/gene/9595:NCK1 ^@ http://purl.uniprot.org/uniprot/G3SC98 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Endoplasmic reticulum http://togogenome.org/gene/9595:TTI2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z055|||http://purl.uniprot.org/uniprot/G3R4N2 ^@ Similarity ^@ Belongs to the TTI2 family. http://togogenome.org/gene/9595:NAA11 ^@ http://purl.uniprot.org/uniprot/G3RAZ1 ^@ Similarity ^@ Belongs to the acetyltransferase family. ARD1 subfamily. http://togogenome.org/gene/9595:SLC15A2 ^@ http://purl.uniprot.org/uniprot/G3R7I5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Interacts (via extracellular domain region) with trypsin.|||Membrane http://togogenome.org/gene/9595:EXOSC1 ^@ http://purl.uniprot.org/uniprot/G3QKR7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:LOC109029337 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y872 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/9595:IER2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z5D6 ^@ Similarity ^@ Belongs to the IER family. http://togogenome.org/gene/9595:PROX1 ^@ http://purl.uniprot.org/uniprot/G3RGL5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:WNT1 ^@ http://purl.uniprot.org/uniprot/G3R6M9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9595:LOC101135475 ^@ http://purl.uniprot.org/uniprot/G3R9B6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:OGT ^@ http://purl.uniprot.org/uniprot/G3RFX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.|||Cell projection|||Mitochondrion membrane http://togogenome.org/gene/9595:PGLYRP2 ^@ http://purl.uniprot.org/uniprot/G3SBB6 ^@ Similarity ^@ Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. http://togogenome.org/gene/9595:TMEM54 ^@ http://purl.uniprot.org/uniprot/G3QL58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM54 family.|||Membrane http://togogenome.org/gene/9595:NAV1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z906 ^@ Similarity ^@ Belongs to the Nav/unc-53 family. http://togogenome.org/gene/9595:SPAG7 ^@ http://purl.uniprot.org/uniprot/G3R1B3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:LOC101132158 ^@ http://purl.uniprot.org/uniprot/G3SAY3 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9595:HTATSF1 ^@ http://purl.uniprot.org/uniprot/G3SAI5 ^@ Similarity ^@ Belongs to the HTATSF1 family. http://togogenome.org/gene/9595:CAPZA2 ^@ http://purl.uniprot.org/uniprot/Q2IBE7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).|||Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5. Interacts with RCSD1/CAPZIP (By similarity). Directly interacts with CRACD; this interaction decreases binding to actin (By similarity). http://togogenome.org/gene/9595:VCAN ^@ http://purl.uniprot.org/uniprot/A0A2I2YZ66|||http://purl.uniprot.org/uniprot/A0A2I2Z3I6|||http://purl.uniprot.org/uniprot/G3RJ07 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aggrecan/versican proteoglycan family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9595:LOC101144541 ^@ http://purl.uniprot.org/uniprot/G3QV42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFI6/IFI27 family.|||Membrane http://togogenome.org/gene/9595:VIPR2 ^@ http://purl.uniprot.org/uniprot/G3QWR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:TGM2 ^@ http://purl.uniprot.org/uniprot/G3RCE0 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9595:CNP ^@ http://purl.uniprot.org/uniprot/A0A2I2ZL34 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 2H phosphoesterase superfamily. CNPase family.|||Exists as monomers and homodimers.|||May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.|||Melanosome|||Membrane http://togogenome.org/gene/9595:LOC101127756 ^@ http://purl.uniprot.org/uniprot/G3SCT4 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9595:NR4A2 ^@ http://purl.uniprot.org/uniprot/G3R6F3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family.|||Cytoplasm|||Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.|||Nucleus http://togogenome.org/gene/9595:LYRM4 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y8E0|||http://purl.uniprot.org/uniprot/A0A2I2Z0B2 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9595:SPX ^@ http://purl.uniprot.org/uniprot/G3R5W9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the spexin family.|||Secreted http://togogenome.org/gene/9595:DCLRE1B ^@ http://purl.uniprot.org/uniprot/G3R6Z4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/9595:NOP14 ^@ http://purl.uniprot.org/uniprot/A0A2I2YTS7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP14 family.|||Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.|||nucleolus http://togogenome.org/gene/9595:STARD5 ^@ http://purl.uniprot.org/uniprot/G3QR04 ^@ Function ^@ May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols. http://togogenome.org/gene/9595:TLE2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YHK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat Groucho/TLE family.|||Nucleus http://togogenome.org/gene/9595:NCAN ^@ http://purl.uniprot.org/uniprot/G3QKF4 ^@ Caution|||Similarity ^@ Belongs to the aggrecan/versican proteoglycan family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:AQP12A ^@ http://purl.uniprot.org/uniprot/G3S3X2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.|||Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.|||Membrane http://togogenome.org/gene/9595:PITX2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZPC2|||http://purl.uniprot.org/uniprot/G3R095 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9595:CEP57L1 ^@ http://purl.uniprot.org/uniprot/G3RG76 ^@ Similarity ^@ Belongs to the translokin family. http://togogenome.org/gene/9595:SERPINA11 ^@ http://purl.uniprot.org/uniprot/G3QN70 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9595:MAP2K2 ^@ http://purl.uniprot.org/uniprot/G3R0F2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:LOC101132466 ^@ http://purl.uniprot.org/uniprot/G3R4U9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX15/CtaA family.|||Membrane http://togogenome.org/gene/9595:CDK5RAP3 ^@ http://purl.uniprot.org/uniprot/G3S7B3 ^@ Similarity ^@ Belongs to the CDK5RAP3 family. http://togogenome.org/gene/9595:SESN3 ^@ http://purl.uniprot.org/uniprot/G3QQF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/9595:CCNL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZDS2|||http://purl.uniprot.org/uniprot/G3SAX2 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9595:LOC101140564 ^@ http://purl.uniprot.org/uniprot/G3QKW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:GRIN2A ^@ http://purl.uniprot.org/uniprot/G3R0C0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/9595:CHRNA10 ^@ http://purl.uniprot.org/uniprot/G3R215 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9595:INTS8 ^@ http://purl.uniprot.org/uniprot/G3QRQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 8 family.|||Nucleus http://togogenome.org/gene/9595:PROK2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZGH7|||http://purl.uniprot.org/uniprot/G3RZL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AVIT (prokineticin) family.|||Secreted http://togogenome.org/gene/9595:NUP133 ^@ http://purl.uniprot.org/uniprot/G3S1E4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin Nup133 family.|||nuclear pore complex http://togogenome.org/gene/9595:MAB21L3 ^@ http://purl.uniprot.org/uniprot/G3QIQ7 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9595:SAR1A ^@ http://purl.uniprot.org/uniprot/G3S6V8 ^@ Similarity ^@ Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/9595:MCM10 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZA30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM10 family.|||Nucleus http://togogenome.org/gene/9595:KCNC4 ^@ http://purl.uniprot.org/uniprot/G3SH62 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:ACAT2 ^@ http://purl.uniprot.org/uniprot/G3RDU7 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/9595:TLCD3A ^@ http://purl.uniprot.org/uniprot/G3RHK4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:GPR161 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z0H8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:AASDH ^@ http://purl.uniprot.org/uniprot/G3S7P1 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9595:RSPO1 ^@ http://purl.uniprot.org/uniprot/G3QXJ8 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/9595:ZNRF3 ^@ http://purl.uniprot.org/uniprot/G3SG16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZNRF3 family.|||Cell membrane http://togogenome.org/gene/9595:STOML1 ^@ http://purl.uniprot.org/uniprot/G3RFS7 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/9595:EEF1A1 ^@ http://purl.uniprot.org/uniprot/G3S518 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/9595:IL2 ^@ http://purl.uniprot.org/uniprot/G3S1Y8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-2 family.|||Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.|||Secreted http://togogenome.org/gene/9595:API5 ^@ http://purl.uniprot.org/uniprot/A0A2I2YNY1 ^@ Similarity ^@ Belongs to the API5 family. http://togogenome.org/gene/9595:DBX1 ^@ http://purl.uniprot.org/uniprot/G3RFV5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SLC28A1 ^@ http://purl.uniprot.org/uniprot/G3SDJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Membrane http://togogenome.org/gene/9595:KDM4D ^@ http://purl.uniprot.org/uniprot/G3R3M4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:EMG1 ^@ http://purl.uniprot.org/uniprot/G3QNS9 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family. http://togogenome.org/gene/9595:NCBP1 ^@ http://purl.uniprot.org/uniprot/G3QGA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NCBP1 family.|||Nucleus http://togogenome.org/gene/9595:ACTL6A ^@ http://purl.uniprot.org/uniprot/G3RI40 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9595:SLC16A4 ^@ http://purl.uniprot.org/uniprot/A0A2I2YLD9|||http://purl.uniprot.org/uniprot/G3RJW7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:EFS ^@ http://purl.uniprot.org/uniprot/G3RLP9 ^@ Similarity ^@ Belongs to the CAS family. http://togogenome.org/gene/9595:LYVE1 ^@ http://purl.uniprot.org/uniprot/G3SG32 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:ZNF75D ^@ http://purl.uniprot.org/uniprot/A0A2I2Z4A5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:MYH4 ^@ http://purl.uniprot.org/uniprot/G3R1E5 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9595:PRCP ^@ http://purl.uniprot.org/uniprot/G3RZ16 ^@ Similarity ^@ Belongs to the peptidase S28 family. http://togogenome.org/gene/9595:EPC2 ^@ http://purl.uniprot.org/uniprot/G3R6Q1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enhancer of polycomb family.|||Nucleus http://togogenome.org/gene/9595:PARP3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z4X0|||http://purl.uniprot.org/uniprot/G3R9R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARTD/PARP family.|||Nucleus http://togogenome.org/gene/9595:AMER3 ^@ http://purl.uniprot.org/uniprot/G3QSD0 ^@ Similarity ^@ Belongs to the Amer family. http://togogenome.org/gene/9595:PDLIM3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZNC2 ^@ Subcellular Location Annotation ^@ Z line http://togogenome.org/gene/9595:CDC42BPA ^@ http://purl.uniprot.org/uniprot/A0A2I2Y6T2|||http://purl.uniprot.org/uniprot/A0A2I2ZFG1|||http://purl.uniprot.org/uniprot/A0A2I2ZUM1|||http://purl.uniprot.org/uniprot/G3SI75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.|||Cytoplasm|||lamellipodium http://togogenome.org/gene/9595:IL22 ^@ http://purl.uniprot.org/uniprot/G3R0Q5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Secreted http://togogenome.org/gene/9595:SMC5 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZDE4|||http://purl.uniprot.org/uniprot/G3RKD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC5 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/9595:ESRRG ^@ http://purl.uniprot.org/uniprot/G3R425|||http://purl.uniprot.org/uniprot/G3R430 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/9595:UCP1 ^@ http://purl.uniprot.org/uniprot/G3RQZ0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||May undergo ubiquitin-mediated proteasomal degradation.|||Membrane|||Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:SLC7A14 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y2E8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:CPLANE2 ^@ http://purl.uniprot.org/uniprot/G3QNW1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.|||cilium basal body http://togogenome.org/gene/9595:XYLB ^@ http://purl.uniprot.org/uniprot/G3RGB6 ^@ Function|||Similarity ^@ Belongs to the FGGY kinase family.|||Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis. http://togogenome.org/gene/9595:BOD1 ^@ http://purl.uniprot.org/uniprot/G3R5R4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BOD1 family.|||centrosome|||kinetochore http://togogenome.org/gene/9595:CASR ^@ http://purl.uniprot.org/uniprot/G3RWV3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:PRICKLE2 ^@ http://purl.uniprot.org/uniprot/G3QVK9 ^@ Similarity ^@ Belongs to the prickle / espinas / testin family. http://togogenome.org/gene/9595:CAMKMT ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1G4 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9595:LOC101126372 ^@ http://purl.uniprot.org/uniprot/A0A2I2YM82 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9595:DEFA4 ^@ http://purl.uniprot.org/uniprot/G3R5N8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-defensin family.|||Secreted http://togogenome.org/gene/9595:DNAJA2 ^@ http://purl.uniprot.org/uniprot/G3RTX7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:CEP20 ^@ http://purl.uniprot.org/uniprot/A0A2I2YNC7|||http://purl.uniprot.org/uniprot/A0A2I2ZGE5|||http://purl.uniprot.org/uniprot/G3SEW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP43 family.|||centriole|||cilium basal body http://togogenome.org/gene/9595:LOC101139203 ^@ http://purl.uniprot.org/uniprot/G3QQ13 ^@ Function|||Similarity ^@ Belongs to the cytochrome c oxidase subunit 6B.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. http://togogenome.org/gene/9595:LEPROT ^@ http://purl.uniprot.org/uniprot/A0A2I2Z0W5|||http://purl.uniprot.org/uniprot/A0A2I2Z5S8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OB-RGRP/VPS55 family.|||Membrane http://togogenome.org/gene/9595:SLCO1C1 ^@ http://purl.uniprot.org/uniprot/G3RFA7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:IRF2 ^@ http://purl.uniprot.org/uniprot/G3RK92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Nucleus http://togogenome.org/gene/9595:SSR1 ^@ http://purl.uniprot.org/uniprot/G3RQC7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-alpha family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.|||Membrane|||Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. http://togogenome.org/gene/9595:LOC101123970 ^@ http://purl.uniprot.org/uniprot/G3QUG0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NSE1 family.|||Component of the Smc5-Smc6 complex.|||Nucleus|||RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.|||telomere http://togogenome.org/gene/9595:GLCE ^@ http://purl.uniprot.org/uniprot/G3RKT8 ^@ Similarity ^@ Belongs to the D-glucuronyl C5-epimerase family. http://togogenome.org/gene/9595:KRT77 ^@ http://purl.uniprot.org/uniprot/G3SAV9 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:CD163 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZPE3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:SIX5 ^@ http://purl.uniprot.org/uniprot/G3SBS4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SCN3B ^@ http://purl.uniprot.org/uniprot/G3QXH2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.|||Membrane|||Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. http://togogenome.org/gene/9595:DACT1 ^@ http://purl.uniprot.org/uniprot/G3RRC9 ^@ Similarity ^@ Belongs to the dapper family. http://togogenome.org/gene/9595:SLC1A5 ^@ http://purl.uniprot.org/uniprot/G3R0B3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9595:AOC2 ^@ http://purl.uniprot.org/uniprot/G3QY85 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the copper/topaquinone oxidase family.|||Contains 1 topaquinone per subunit.|||Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. http://togogenome.org/gene/9595:CACNB3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YK89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||Cytoplasm http://togogenome.org/gene/9595:FAM241B ^@ http://purl.uniprot.org/uniprot/G3QIE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM241 family.|||Membrane http://togogenome.org/gene/9595:MED27 ^@ http://purl.uniprot.org/uniprot/A0A2I2YFN3|||http://purl.uniprot.org/uniprot/A0A2I2ZIL1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 27 family.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9595:P2RX1 ^@ http://purl.uniprot.org/uniprot/G3S4B8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9595:LOC101134521 ^@ http://purl.uniprot.org/uniprot/G3R462 ^@ Function|||Similarity ^@ Belongs to the SAA family.|||Major acute phase reactant. Apolipoprotein of the HDL complex. http://togogenome.org/gene/9595:PGC ^@ http://purl.uniprot.org/uniprot/G3QJP9 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/9595:WNT10B ^@ http://purl.uniprot.org/uniprot/G3R6M5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9595:SYCP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YZM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SYCP2 family.|||Nucleus http://togogenome.org/gene/9595:LDLR ^@ http://purl.uniprot.org/uniprot/A0A2I2YUC0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:MOB3B ^@ http://purl.uniprot.org/uniprot/G3QPL3 ^@ Similarity ^@ Belongs to the MOB1/phocein family. http://togogenome.org/gene/9595:LOC101127471 ^@ http://purl.uniprot.org/uniprot/G3RQ60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:PEBP1 ^@ http://purl.uniprot.org/uniprot/G3RBU0 ^@ Similarity ^@ Belongs to the phosphatidylethanolamine-binding protein family. http://togogenome.org/gene/9595:SIDT1 ^@ http://purl.uniprot.org/uniprot/G3RJW2|||http://purl.uniprot.org/uniprot/G3S099 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SID1 family.|||Membrane http://togogenome.org/gene/9595:ATL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z073 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9595:CENPO ^@ http://purl.uniprot.org/uniprot/A0A2I2YWJ9|||http://purl.uniprot.org/uniprot/A0A2I2ZC01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-O/MCM21 family.|||Nucleus http://togogenome.org/gene/9595:GPC6 ^@ http://purl.uniprot.org/uniprot/G3S143 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/9595:DEFB113 ^@ http://purl.uniprot.org/uniprot/G3SAD7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9595:ALDH3A2 ^@ http://purl.uniprot.org/uniprot/G3QXF5 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9595:MAN2A1 ^@ http://purl.uniprot.org/uniprot/G3QGR6 ^@ Cofactor|||Similarity ^@ Belongs to the glycosyl hydrolase 38 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9595:PSMC5 ^@ http://purl.uniprot.org/uniprot/G3QV98 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9595:PGR ^@ http://purl.uniprot.org/uniprot/A7X8B7 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family.|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.|||Cytoplasm|||Interacts with SMARD1 and UNC45A. Interacts with CUEDC2; the interaction promotes ubiquitination, decreases sumoylation, and represses transcriptional activity. Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export. Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-345 by ERK1/2-MAPK. Interacts with PRMT2. Interacts with NCOA2 and NCOA1. Interacts with KLF9. Interacts with GTF2B (By similarity).|||Nucleus|||Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation (By similarity).|||Phosphorylated on multiple serine sites. Several of these sites are hormone-dependent. Phosphorylation on Ser-294 is highly hormone-dependent and modulates ubiquitination and sumoylation on Lys-388. Phosphorylation on Ser-102 and Ser-345 also requires induction by hormone. Basal phosphorylation on Ser-81, Ser-162, Ser-190 and Ser-400 is increased in response to progesterone and can be phosphorylated in vitro by the CDK2-A1 complex. Increased levels of phosphorylation on Ser-400 also in the presence of EGF, heregulin, IGF, PMA and FBS. Phosphorylation at this site by CDK2 is ligand-independent, and increases nuclear translocation and transcriptional activity. Phosphorylation at Ser-162 and Ser-294, but not at Ser-190, is impaired during the G(2)/M phase of the cell cycle. Phosphorylation on Ser-345 by ERK1/2 MAPK is required for interaction with SP1 (By similarity).|||Sumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three sites is enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-388, the main site of sumoylation, is repressed by ubiquitination on the same site, and modulated by phosphorylation at Ser-294 (By similarity).|||The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.|||Ubiquitination is hormone-dependent and represses sumoylation on the same site. Promoted by MAPK-mediated phosphorylation on Ser-294 (By similarity). http://togogenome.org/gene/9595:GPN1 ^@ http://purl.uniprot.org/uniprot/G3RH01 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II.|||Cytoplasm|||Nucleus|||Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/9595:ATP5F1A ^@ http://purl.uniprot.org/uniprot/G3RK98 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/9595:AFG1L ^@ http://purl.uniprot.org/uniprot/G3QNP4 ^@ Similarity ^@ Belongs to the AFG1 ATPase family. http://togogenome.org/gene/9595:MRPL33 ^@ http://purl.uniprot.org/uniprot/A0A2I2YQY9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/9595:SLC26A6 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y4N0|||http://purl.uniprot.org/uniprot/G3SBK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/9595:ZW10 ^@ http://purl.uniprot.org/uniprot/G3RUL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZW10 family.|||kinetochore http://togogenome.org/gene/9595:CCL11 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZAI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9595:PLSCR5 ^@ http://purl.uniprot.org/uniprot/G3RZ11 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/9595:TSPAN1 ^@ http://purl.uniprot.org/uniprot/G3S2H2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9595:ACKR1 ^@ http://purl.uniprot.org/uniprot/Q95LF9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels (By similarity).|||Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.|||Early endosome|||Membrane|||Recycling endosome http://togogenome.org/gene/9595:RALYL ^@ http://purl.uniprot.org/uniprot/A0A2I2ZTI4 ^@ Similarity ^@ Belongs to the RRM HNRPC family. RALY subfamily. http://togogenome.org/gene/9595:ATAD2 ^@ http://purl.uniprot.org/uniprot/G3R1V2 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9595:EPS8 ^@ http://purl.uniprot.org/uniprot/G3S4A2 ^@ Similarity ^@ Belongs to the EPS8 family. http://togogenome.org/gene/9595:ECI1 ^@ http://purl.uniprot.org/uniprot/G3RED3 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9595:TMEM216 ^@ http://purl.uniprot.org/uniprot/G3RZ04 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:SCD5 ^@ http://purl.uniprot.org/uniprot/A0A2I2YTX0 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Membrane|||The histidine box domains are involved in binding the catalytic metal ions. http://togogenome.org/gene/9595:IFI6 ^@ http://purl.uniprot.org/uniprot/G3QER5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFI6/IFI27 family.|||Membrane http://togogenome.org/gene/9595:AADACL3 ^@ http://purl.uniprot.org/uniprot/G3S7Q3 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/9595:SFRP2 ^@ http://purl.uniprot.org/uniprot/G3QH51 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:PRKAR1A ^@ http://purl.uniprot.org/uniprot/G3RK51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:LMX1A ^@ http://purl.uniprot.org/uniprot/G3QL82 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:INCENP ^@ http://purl.uniprot.org/uniprot/A0A2I2Z5V9|||http://purl.uniprot.org/uniprot/G3S276 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INCENP family.|||Midbody|||Nucleus|||kinetochore|||spindle http://togogenome.org/gene/9595:RPAIN ^@ http://purl.uniprot.org/uniprot/A0A2I2YA76|||http://purl.uniprot.org/uniprot/A0A2I2YLB4|||http://purl.uniprot.org/uniprot/A0A2I2ZV45|||http://purl.uniprot.org/uniprot/G3QJU6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:PDHA1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y5G2 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. http://togogenome.org/gene/9595:FBXO46 ^@ http://purl.uniprot.org/uniprot/G3RWS6 ^@ Function ^@ Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. http://togogenome.org/gene/9595:DYNLRB2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZFJ8|||http://purl.uniprot.org/uniprot/G3R016 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.|||Belongs to the GAMAD family.|||Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.|||cytoskeleton http://togogenome.org/gene/9595:MAL2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YFT4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:HEATR5A ^@ http://purl.uniprot.org/uniprot/G3QEF3 ^@ Similarity ^@ Belongs to the HEATR5 family. http://togogenome.org/gene/9595:MOB1B ^@ http://purl.uniprot.org/uniprot/G3QLF3 ^@ Similarity ^@ Belongs to the MOB1/phocein family. http://togogenome.org/gene/9595:ANO5 ^@ http://purl.uniprot.org/uniprot/G3RKI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:SCP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YEU2|||http://purl.uniprot.org/uniprot/G3R735 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. Thiolase family.|||Cytoplasm|||Interacts with PEX5; the interaction is essential for peroxisomal import.|||Mitochondrion http://togogenome.org/gene/9595:CTSV ^@ http://purl.uniprot.org/uniprot/G3S2T1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9595:SCNN1A ^@ http://purl.uniprot.org/uniprot/G3R5I8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:ARL11 ^@ http://purl.uniprot.org/uniprot/G3QP69 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9595:MMP20 ^@ http://purl.uniprot.org/uniprot/G3QLA8 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9595:TUB ^@ http://purl.uniprot.org/uniprot/A0A2I2YZ12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TUB family.|||Secreted http://togogenome.org/gene/9595:JPH2 ^@ http://purl.uniprot.org/uniprot/G3QUZ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the junctophilin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.|||Membrane http://togogenome.org/gene/9595:ACOT8 ^@ http://purl.uniprot.org/uniprot/G3QKM8 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/9595:EFEMP1 ^@ http://purl.uniprot.org/uniprot/G3RW79 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:ALDOA ^@ http://purl.uniprot.org/uniprot/A0A2I2Z8Q3 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/9595:SOGA3 ^@ http://purl.uniprot.org/uniprot/G3QCT0 ^@ Similarity ^@ Belongs to the SOGA family. http://togogenome.org/gene/9595:LOC101150653 ^@ http://purl.uniprot.org/uniprot/G3S1W9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:CALHM3 ^@ http://purl.uniprot.org/uniprot/G3R7N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9595:MPHOSPH8 ^@ http://purl.uniprot.org/uniprot/G3QSY3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:TAMM41 ^@ http://purl.uniprot.org/uniprot/A0A2I2YPY6|||http://purl.uniprot.org/uniprot/A0A2I2YYF6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TAM41 family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:LOC101133386 ^@ http://purl.uniprot.org/uniprot/G3RUE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase VIIb family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9595:LBX1 ^@ http://purl.uniprot.org/uniprot/G3R9W2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SFRP5 ^@ http://purl.uniprot.org/uniprot/G3RA14 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:RPL39 ^@ http://purl.uniprot.org/uniprot/G3QXV4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/9595:TAX1BP3 ^@ http://purl.uniprot.org/uniprot/G3R350 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Cytoplasm|||May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.|||Nucleus http://togogenome.org/gene/9595:DEFB110 ^@ http://purl.uniprot.org/uniprot/G3QG52 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9595:LOC101132614 ^@ http://purl.uniprot.org/uniprot/G3S2U1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9595:TM4SF19 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y6E8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9595:UBE2G2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z165 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9595:ZKSCAN2 ^@ http://purl.uniprot.org/uniprot/G3SJK0 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9595:PDX1 ^@ http://purl.uniprot.org/uniprot/A1YF08 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. Binds the DNA sequence 5'-CC[CT]TAATGGG-3' (By similarity).|||Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily.|||Interacts with the basic helix-loop-helix domains of TCF3(E47) and NEUROD1 and with HMG-I(Y). Interacts with SPOP (By similarity).|||Nucleus|||Phosphorylated by the SAPK2 pathway at high intracellular glucose concentration. Phosphorylated by HIPK2 on Ser-269 upon glucose accumulation. This phosphorylation mediates subnuclear localization shifting. Phosphorylation by PASK may lead to translocation into the cytosol (By similarity).|||The Antp-type hexapeptide mediates heterodimerization with PBX on a regulatory element of the somatostatin promoter.|||The homeodomain, which contains the nuclear localization signal, not only mediates DNA-binding, but also acts as a protein-protein interaction domain for TCF3(E47), NEUROD1 and HMG-I(Y).|||cytosol http://togogenome.org/gene/9595:GMFB ^@ http://purl.uniprot.org/uniprot/A0A2I2Z891 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. GMF subfamily. http://togogenome.org/gene/9595:UGT8 ^@ http://purl.uniprot.org/uniprot/G3S0Z3 ^@ Similarity ^@ Belongs to the UDP-glycosyltransferase family. http://togogenome.org/gene/9595:TDRD9 ^@ http://purl.uniprot.org/uniprot/G3QEV0 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DEAH subfamily. http://togogenome.org/gene/9595:FRAS1 ^@ http://purl.uniprot.org/uniprot/G3QKZ2 ^@ Similarity ^@ Belongs to the FRAS1 family. http://togogenome.org/gene/9595:KRT39 ^@ http://purl.uniprot.org/uniprot/G3RLK1 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:MTFR2 ^@ http://purl.uniprot.org/uniprot/G3R0V4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission. http://togogenome.org/gene/9595:CTSB ^@ http://purl.uniprot.org/uniprot/G3QFS2 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9595:BCO1 ^@ http://purl.uniprot.org/uniprot/G3QDC3 ^@ Cofactor|||Similarity ^@ Belongs to the carotenoid oxygenase family.|||Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/9595:DPT ^@ http://purl.uniprot.org/uniprot/G3QLX5 ^@ Similarity ^@ Belongs to the dermatopontin family. http://togogenome.org/gene/9595:GDPGP1 ^@ http://purl.uniprot.org/uniprot/G3SK14 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GDPGP1 family.|||Cytoplasm|||Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells. http://togogenome.org/gene/9595:SNRPD2 ^@ http://purl.uniprot.org/uniprot/G3QIU5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.|||cytosol http://togogenome.org/gene/9595:MMP19 ^@ http://purl.uniprot.org/uniprot/G3RBP6 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9595:CTC1 ^@ http://purl.uniprot.org/uniprot/G3QK61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CTC1 family.|||Nucleus|||telomere http://togogenome.org/gene/9595:NKAP ^@ http://purl.uniprot.org/uniprot/G3RBY6 ^@ Similarity ^@ Belongs to the NKAP family. http://togogenome.org/gene/9595:LOC101124279 ^@ http://purl.uniprot.org/uniprot/G3S2N9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCC3 family.|||Membrane|||Mitochondrion inner membrane|||Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology. http://togogenome.org/gene/9595:TXNL4A ^@ http://purl.uniprot.org/uniprot/G3QRD0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/9595:S1PR3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YLG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:AMIGO2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZSR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. AMIGO family.|||Membrane http://togogenome.org/gene/9595:ABI2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZFI4|||http://purl.uniprot.org/uniprot/A0A2I2ZKM8|||http://purl.uniprot.org/uniprot/A0A2I2ZWH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABI family.|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/9595:PADI1 ^@ http://purl.uniprot.org/uniprot/G3RGE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein arginine deiminase family.|||Catalyzes the deimination of arginine residues of proteins.|||Cytoplasm http://togogenome.org/gene/9595:APOL6 ^@ http://purl.uniprot.org/uniprot/G3QPC4 ^@ Similarity ^@ Belongs to the apolipoprotein L family. http://togogenome.org/gene/9595:FMNL3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YRC4|||http://purl.uniprot.org/uniprot/G3QGU8 ^@ Similarity ^@ Belongs to the formin homology family. http://togogenome.org/gene/9595:RAMAC ^@ http://purl.uniprot.org/uniprot/G3RMB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAM family.|||Nucleus http://togogenome.org/gene/9595:ARF4 ^@ http://purl.uniprot.org/uniprot/G3QDH1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/9595:GLRA2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZB89|||http://purl.uniprot.org/uniprot/G3RA84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/9595:TEX28 ^@ http://purl.uniprot.org/uniprot/G3QNJ2 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/9595:SLC8A1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YRZ6|||http://purl.uniprot.org/uniprot/A0A2I2ZY48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:AKAP12 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y3L9|||http://purl.uniprot.org/uniprot/A0A2I2ZCZ8|||http://purl.uniprot.org/uniprot/G3RQR0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:RUNX3 ^@ http://purl.uniprot.org/uniprot/G3S3J4 ^@ Function|||Subcellular Location Annotation ^@ Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.|||Nucleus http://togogenome.org/gene/9595:NCL ^@ http://purl.uniprot.org/uniprot/G3QNU5 ^@ Function|||Subcellular Location Annotation ^@ Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.|||nucleolus http://togogenome.org/gene/9595:EBPL ^@ http://purl.uniprot.org/uniprot/G3RQ64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:TOMM20L ^@ http://purl.uniprot.org/uniprot/G3QH89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom20 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9595:IREB2 ^@ http://purl.uniprot.org/uniprot/G3RHZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Cytoplasm http://togogenome.org/gene/9595:MAPK8IP3 ^@ http://purl.uniprot.org/uniprot/G3QTQ8|||http://purl.uniprot.org/uniprot/G3RYQ6 ^@ Similarity ^@ Belongs to the JIP scaffold family. http://togogenome.org/gene/9595:HOXD1 ^@ http://purl.uniprot.org/uniprot/G3S0K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Labial subfamily.|||Nucleus http://togogenome.org/gene/9595:RSBN1 ^@ http://purl.uniprot.org/uniprot/G3QMN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the round spermatid basic protein 1 family.|||Nucleus http://togogenome.org/gene/9595:SLC37A1 ^@ http://purl.uniprot.org/uniprot/G3R8R7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.|||Membrane http://togogenome.org/gene/9595:BECN1 ^@ http://purl.uniprot.org/uniprot/G3QGV1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.|||Belongs to the beclin family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Endosome membrane|||Membrane|||Mitochondrion membrane|||Plays a central role in autophagy.|||autophagosome|||trans-Golgi network membrane http://togogenome.org/gene/9595:FAAH ^@ http://purl.uniprot.org/uniprot/G3RF81 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/9595:E2F8 ^@ http://purl.uniprot.org/uniprot/G3S6E1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9595:NNAT ^@ http://purl.uniprot.org/uniprot/A0A2I2ZHK7|||http://purl.uniprot.org/uniprot/G3QPM1 ^@ Similarity ^@ Belongs to the neuronatin family. http://togogenome.org/gene/9595:GPC3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZY02 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/9595:NLGN3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y1Q6|||http://purl.uniprot.org/uniprot/A0A2I2YXQ3|||http://purl.uniprot.org/uniprot/G3RBW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:CISD2 ^@ http://purl.uniprot.org/uniprot/G3QGA2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CISD protein family. CISD2 subfamily.|||Binds 1 [2Fe-2S] cluster.|||Endoplasmic reticulum membrane|||Homodimer.|||Mitochondrion outer membrane|||Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. http://togogenome.org/gene/9595:TIPARP ^@ http://purl.uniprot.org/uniprot/G3RX27 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9595:MAT1A ^@ http://purl.uniprot.org/uniprot/G3QSU0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/9595:MTHFS ^@ http://purl.uniprot.org/uniprot/A0A2I2ZGX5|||http://purl.uniprot.org/uniprot/G3R914 ^@ Similarity ^@ Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. http://togogenome.org/gene/9595:HPS6 ^@ http://purl.uniprot.org/uniprot/G3R0K6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6. Interacts with HPS5 and HPS3. Interacts with biogenesis of lysosome-related organelles complex-1 (BLOC1). Interacts with AP-3 complex.|||May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.|||Microsome membrane http://togogenome.org/gene/9595:CCN4 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z7K7|||http://purl.uniprot.org/uniprot/G3RGS7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9595:USP26 ^@ http://purl.uniprot.org/uniprot/G3SHA9 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9595:ZBED1 ^@ http://purl.uniprot.org/uniprot/G3R7R6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SUSD3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZUS1|||http://purl.uniprot.org/uniprot/G3R0M6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:GJB1 ^@ http://purl.uniprot.org/uniprot/G3R5C8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins. Interacts with CNST.|||Belongs to the connexin family. Beta-type (group I) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9595:LOC101136257 ^@ http://purl.uniprot.org/uniprot/G3SHJ3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9595:NEUROD4 ^@ http://purl.uniprot.org/uniprot/G3QNT6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:ROMO1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZHZ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGR2 family.|||Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.|||Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:LOC101124249 ^@ http://purl.uniprot.org/uniprot/G3R2I2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9595:TCN2 ^@ http://purl.uniprot.org/uniprot/G3QD18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic cobalamin transport proteins family.|||Secreted http://togogenome.org/gene/9595:SEPTIN4 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZB66|||http://purl.uniprot.org/uniprot/G3RD82|||http://purl.uniprot.org/uniprot/G3RN19 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9595:KIF21B ^@ http://purl.uniprot.org/uniprot/A0A2I2ZHH3|||http://purl.uniprot.org/uniprot/G3S6F9 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9595:CDK15 ^@ http://purl.uniprot.org/uniprot/A0A2I2YJ08 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:HTR1F ^@ http://purl.uniprot.org/uniprot/A0A2I2YK37 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.|||Membrane http://togogenome.org/gene/9595:LOC101130426 ^@ http://purl.uniprot.org/uniprot/G3RHP6 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9595:PSME2 ^@ http://purl.uniprot.org/uniprot/G3S8N8 ^@ Similarity ^@ Belongs to the PA28 family. http://togogenome.org/gene/9595:PDSS2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZV98 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9595:METAP2 ^@ http://purl.uniprot.org/uniprot/G3R026 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Binds EIF2S1 at low magnesium concentrations. Interacts strongly with the eIF-2 gamma-subunit EIF2S3.|||Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).|||Cytoplasm|||Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis. http://togogenome.org/gene/9595:SAP18 ^@ http://purl.uniprot.org/uniprot/G3RF20 ^@ Similarity ^@ Belongs to the SAP18 family. http://togogenome.org/gene/9595:XPC ^@ http://purl.uniprot.org/uniprot/G3R3D5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPC family.|||Nucleus http://togogenome.org/gene/9595:LOC101132732 ^@ http://purl.uniprot.org/uniprot/G3QQ68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:RFC4 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y7Y2 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/9595:PSPC1 ^@ http://purl.uniprot.org/uniprot/G3QLK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PSPC family.|||Cytoplasm|||Nucleus matrix|||Nucleus speckle|||nucleolus http://togogenome.org/gene/9595:BBS2 ^@ http://purl.uniprot.org/uniprot/G3RIZ2 ^@ Subcellular Location Annotation ^@ centriolar satellite|||cilium membrane http://togogenome.org/gene/9595:SMO ^@ http://purl.uniprot.org/uniprot/G3QL33 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||cilium http://togogenome.org/gene/9595:PYCARD ^@ http://purl.uniprot.org/uniprot/G3RLS4 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Inflammasome http://togogenome.org/gene/9595:PPM1K ^@ http://purl.uniprot.org/uniprot/G3QJW6 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9595:KLHL3 ^@ http://purl.uniprot.org/uniprot/G3S417 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KLHL3 family.|||cytoskeleton|||cytosol http://togogenome.org/gene/9595:SCRN1 ^@ http://purl.uniprot.org/uniprot/G3QSH3 ^@ Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily. http://togogenome.org/gene/9595:RIMKLA ^@ http://purl.uniprot.org/uniprot/G3S078 ^@ Similarity ^@ Belongs to the RimK family. http://togogenome.org/gene/9595:SLC5A7 ^@ http://purl.uniprot.org/uniprot/G3QXT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:TMC8 ^@ http://purl.uniprot.org/uniprot/G3QVS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMC family.|||Membrane http://togogenome.org/gene/9595:FAM98A ^@ http://purl.uniprot.org/uniprot/G3SJ47 ^@ Similarity ^@ Belongs to the FAM98 family. http://togogenome.org/gene/9595:DMTF1 ^@ http://purl.uniprot.org/uniprot/G3QJY1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:LOC101131776 ^@ http://purl.uniprot.org/uniprot/G3RDZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 6A family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9595:CCL7 ^@ http://purl.uniprot.org/uniprot/G3QPB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9595:FNBP1L ^@ http://purl.uniprot.org/uniprot/A0A2I2YEJ0|||http://purl.uniprot.org/uniprot/G3S9L3|||http://purl.uniprot.org/uniprot/G3SIM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNBP1 family.|||Cell membrane|||Cytoplasmic vesicle|||Membrane|||Vesicle|||cell cortex|||cytoskeleton http://togogenome.org/gene/9595:BET1L ^@ http://purl.uniprot.org/uniprot/A0A2I2YYB2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:LOC101143345 ^@ http://purl.uniprot.org/uniprot/G3RWP2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:RAMP1 ^@ http://purl.uniprot.org/uniprot/G3RNM5 ^@ Similarity ^@ Belongs to the RAMP family. http://togogenome.org/gene/9595:DNAH8 ^@ http://purl.uniprot.org/uniprot/G3RF10 ^@ Similarity ^@ Belongs to the dynein heavy chain family. http://togogenome.org/gene/9595:GLRX ^@ http://purl.uniprot.org/uniprot/G3R1A5 ^@ Function|||Similarity ^@ Belongs to the glutaredoxin family.|||Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. http://togogenome.org/gene/9595:SMC2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZG35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC2 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/9595:SERPINF1 ^@ http://purl.uniprot.org/uniprot/G3QDC6 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9595:ADGRG3 ^@ http://purl.uniprot.org/uniprot/G3QZF8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:PPP2R2A ^@ http://purl.uniprot.org/uniprot/G3RM99 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/9595:WASF2 ^@ http://purl.uniprot.org/uniprot/G3RPV9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCAR/WAVE family.|||Binds actin and the Arp2/3 complex.|||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|||cytoskeleton http://togogenome.org/gene/9595:MEOX1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZCA0|||http://purl.uniprot.org/uniprot/G3QKL7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:CC2D1B ^@ http://purl.uniprot.org/uniprot/G3QD75|||http://purl.uniprot.org/uniprot/G3SJN8 ^@ Similarity ^@ Belongs to the CC2D1 family. http://togogenome.org/gene/9595:GPR87 ^@ http://purl.uniprot.org/uniprot/A0A2I2YC71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:TOP1 ^@ http://purl.uniprot.org/uniprot/G3R0W2 ^@ Function|||Similarity ^@ Belongs to the type IB topoisomerase family.|||Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/9595:GNAI3 ^@ http://purl.uniprot.org/uniprot/G3SCU6 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9595:NAPB ^@ http://purl.uniprot.org/uniprot/G3QZP4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/9595:TET2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y4W1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TET family.|||Binds 1 Fe(2+) ion per subunit.|||Chromosome|||Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.|||The zinc ions have a structural role. http://togogenome.org/gene/9595:LOC101139491 ^@ http://purl.uniprot.org/uniprot/G3R5M1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:TSPAN5 ^@ http://purl.uniprot.org/uniprot/G3SGT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9595:MED17 ^@ http://purl.uniprot.org/uniprot/G3SAE8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 17 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9595:PIK3R3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z117|||http://purl.uniprot.org/uniprot/G3R3X8 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/9595:CUL2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YYC6 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9595:SMAD7 ^@ http://purl.uniprot.org/uniprot/G3R4S9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:ARPC5L ^@ http://purl.uniprot.org/uniprot/G3QNC4 ^@ Function|||Similarity ^@ Belongs to the ARPC5 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. http://togogenome.org/gene/9595:LOC101143702 ^@ http://purl.uniprot.org/uniprot/G3RZ81 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/9595:LOC101125803 ^@ http://purl.uniprot.org/uniprot/G3SKC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Secreted http://togogenome.org/gene/9595:SRP19 ^@ http://purl.uniprot.org/uniprot/G3SI21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP19 family.|||Cytoplasm http://togogenome.org/gene/9595:LOC101152574 ^@ http://purl.uniprot.org/uniprot/G3RRM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:SGK1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YET3|||http://purl.uniprot.org/uniprot/A0A2I2YMZ6|||http://purl.uniprot.org/uniprot/G3QGL7|||http://purl.uniprot.org/uniprot/G3S3Y0 ^@ Similarity ^@ Belongs to the protein kinase superfamily.|||Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/9595:GPR37L1 ^@ http://purl.uniprot.org/uniprot/G3RQ21 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:IGFBP6 ^@ http://purl.uniprot.org/uniprot/G3QKV6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9595:NFE2L1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YX86|||http://purl.uniprot.org/uniprot/G3QIM0|||http://purl.uniprot.org/uniprot/G3SBU6 ^@ Similarity ^@ Belongs to the bZIP family. CNC subfamily. http://togogenome.org/gene/9595:ADRA1B ^@ http://purl.uniprot.org/uniprot/G3QHV1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Membrane|||Nucleus membrane|||This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.|||caveola http://togogenome.org/gene/9595:MRS2 ^@ http://purl.uniprot.org/uniprot/G3R146 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:NR1H3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZHW6|||http://purl.uniprot.org/uniprot/G3QZS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9595:ORC5 ^@ http://purl.uniprot.org/uniprot/G3QFC8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:RPS27 ^@ http://purl.uniprot.org/uniprot/G3S0D8 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9595:NAF1 ^@ http://purl.uniprot.org/uniprot/G3QF20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAF1 family.|||Nucleus http://togogenome.org/gene/9595:SYT1 ^@ http://purl.uniprot.org/uniprot/G3S3Z1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.|||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.|||synaptic vesicle membrane http://togogenome.org/gene/9595:OBP2B ^@ http://purl.uniprot.org/uniprot/G3R204 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/9595:CHURC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YS44|||http://purl.uniprot.org/uniprot/A0A2I2Z3V6 ^@ Similarity ^@ Belongs to the Churchill family. http://togogenome.org/gene/9595:XRCC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y8B4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SSBP1 ^@ http://purl.uniprot.org/uniprot/G3R2E1 ^@ Subcellular Location Annotation ^@ mitochondrion nucleoid http://togogenome.org/gene/9595:FAM221A ^@ http://purl.uniprot.org/uniprot/A0A2I2Y8K3|||http://purl.uniprot.org/uniprot/A0A2I2YCH6|||http://purl.uniprot.org/uniprot/G3QG28 ^@ Similarity ^@ Belongs to the FAM221 family. http://togogenome.org/gene/9595:DUOX2 ^@ http://purl.uniprot.org/uniprot/G3R7S7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.|||In the N-terminal section; belongs to the peroxidase family.|||Membrane http://togogenome.org/gene/9595:GBP6 ^@ http://purl.uniprot.org/uniprot/G3R5E0 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9595:MOK ^@ http://purl.uniprot.org/uniprot/G3QTB2|||http://purl.uniprot.org/uniprot/G3SHC6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:HOXD4 ^@ http://purl.uniprot.org/uniprot/A1YER7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Antp homeobox family. Deformed subfamily.|||Forms a DNA-binding heterodimer with transcription factor PBX1.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/9595:MRPL35 ^@ http://purl.uniprot.org/uniprot/G3SB05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bL35 family.|||Mitochondrion http://togogenome.org/gene/9595:CTSO ^@ http://purl.uniprot.org/uniprot/G3RJD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9595:MARS2 ^@ http://purl.uniprot.org/uniprot/G3SKQ2 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9595:TMA16 ^@ http://purl.uniprot.org/uniprot/G3RQG7 ^@ Function|||Similarity|||Subunit ^@ Associates with pre-60S ribosomal particles.|||Belongs to the TMA16 family.|||Involved in the biogenesis of the 60S ribosomal subunit in the nucleus. http://togogenome.org/gene/9595:TBXT ^@ http://purl.uniprot.org/uniprot/G3QXI2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9595:PAPSS2 ^@ http://purl.uniprot.org/uniprot/G3SB39 ^@ Similarity ^@ In the C-terminal section; belongs to the sulfate adenylyltransferase family.|||In the N-terminal section; belongs to the APS kinase family. http://togogenome.org/gene/9595:CALHM5 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z0T8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9595:ATP6V1G1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1I5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9595:PRDM10 ^@ http://purl.uniprot.org/uniprot/G3SEU8 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9595:KCNJ1 ^@ http://purl.uniprot.org/uniprot/G3QQD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9595:BDNF ^@ http://purl.uniprot.org/uniprot/A0A2I2YYY5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NGF-beta family.|||During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.|||Monomers and homodimers. Binds to NTRK2/TRKB.|||Secreted http://togogenome.org/gene/9595:SLC6A1 ^@ http://purl.uniprot.org/uniprot/G3QDQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9595:ITGAM ^@ http://purl.uniprot.org/uniprot/G3QN92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9595:CSTA ^@ http://purl.uniprot.org/uniprot/G3S822 ^@ Similarity ^@ Belongs to the cystatin family. http://togogenome.org/gene/9595:RPL37 ^@ http://purl.uniprot.org/uniprot/G3SHH0 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/9595:TBX4 ^@ http://purl.uniprot.org/uniprot/G3RDF8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9595:MOGAT3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZL00 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:CTSC ^@ http://purl.uniprot.org/uniprot/G3QI81 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C1 family.|||Lysosome|||Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains. http://togogenome.org/gene/9595:BST1 ^@ http://purl.uniprot.org/uniprot/G3R0G4 ^@ Similarity ^@ Belongs to the ADP-ribosyl cyclase family. http://togogenome.org/gene/9595:SELL ^@ http://purl.uniprot.org/uniprot/G3RND1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the selectin/LECAM family.|||Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.|||Cell membrane|||Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:MST1R ^@ http://purl.uniprot.org/uniprot/A0A2I2Y2Q4|||http://purl.uniprot.org/uniprot/G3R996 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:LOC101136556 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z7H9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:VPS52 ^@ http://purl.uniprot.org/uniprot/G3QUM2 ^@ Similarity ^@ Belongs to the VPS52 family. http://togogenome.org/gene/9595:TLX2 ^@ http://purl.uniprot.org/uniprot/G3QTX8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:DEFB123 ^@ http://purl.uniprot.org/uniprot/A4H235 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9595:DCTN4 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZYM7|||http://purl.uniprot.org/uniprot/G3R2X6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunit 4 family.|||cell cortex|||centrosome|||sarcomere|||stress fiber http://togogenome.org/gene/9595:SULT2A1 ^@ http://purl.uniprot.org/uniprot/G3R8Y3 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9595:ATP2C2 ^@ http://purl.uniprot.org/uniprot/G3RHJ3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:CPA5 ^@ http://purl.uniprot.org/uniprot/G3QJ01 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9595:MRPL24 ^@ http://purl.uniprot.org/uniprot/G3RUI4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/9595:CLK3 ^@ http://purl.uniprot.org/uniprot/G3RU80 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:GIPR ^@ http://purl.uniprot.org/uniprot/G3RJ74 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:TOM1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZKN0 ^@ Similarity ^@ Belongs to the TOM1 family. http://togogenome.org/gene/9595:ISL2 ^@ http://purl.uniprot.org/uniprot/G3SG14 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:TLR9 ^@ http://purl.uniprot.org/uniprot/G3RIC3|||http://purl.uniprot.org/uniprot/G3RIE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.|||Endoplasmic reticulum membrane|||Lysosome|||Membrane|||cytoskeleton|||phagosome http://togogenome.org/gene/9595:GNL2 ^@ http://purl.uniprot.org/uniprot/G3QXJ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.|||GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.|||nucleolus http://togogenome.org/gene/9595:DRD5 ^@ http://purl.uniprot.org/uniprot/G3QY32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:TRNAU1AP ^@ http://purl.uniprot.org/uniprot/G3QLT4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TRSPAP family.|||Cytoplasm|||Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis.|||Nucleus http://togogenome.org/gene/9595:OLFML2B ^@ http://purl.uniprot.org/uniprot/G3R0H9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:UNC45B ^@ http://purl.uniprot.org/uniprot/G3SGT4 ^@ Subcellular Location Annotation ^@ A band|||Z line|||perinuclear region http://togogenome.org/gene/9595:LOC101152766 ^@ http://purl.uniprot.org/uniprot/G3RN34 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9595:MYO1E ^@ http://purl.uniprot.org/uniprot/G3QXE8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9595:GJD2 ^@ http://purl.uniprot.org/uniprot/G3S404 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9595:DUSP29 ^@ http://purl.uniprot.org/uniprot/G3R603 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/9595:KRT7 ^@ http://purl.uniprot.org/uniprot/G3QUQ0 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:TSC22D4 ^@ http://purl.uniprot.org/uniprot/G3SD77 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/9595:MYOZ2 ^@ http://purl.uniprot.org/uniprot/G3R4I6 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/9595:DMC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YX58|||http://purl.uniprot.org/uniprot/G3R6H9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. DMC1 subfamily.|||May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.|||Nucleus http://togogenome.org/gene/9595:IDH1 ^@ http://purl.uniprot.org/uniprot/G3RA53 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Homodimer. http://togogenome.org/gene/9595:IRGC ^@ http://purl.uniprot.org/uniprot/G3S785 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. http://togogenome.org/gene/9595:BRCC3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y4Q6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M67A family. BRCC36 subfamily.|||Binds 1 zinc ion per subunit.|||Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1 and BABAM2. Component of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Identified in a complex with SHMT2 and the other subunits of the BRISC complex. In the BRISC complex, interacts directly with ABRAXAS2. Identified in a complex with ABRAXAS2 and NUMA1. The BRISC complex interacts with the CSN complex. Component of the BRCA1/BRCA2 containing complex (BRCC), which also contains BRCA1, BRCA2, BARD1, BABAM2 and RAD51. BRCC is a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage. Interacts with BRCA1. Binds polyubiquitin. Interacts with PWWP2B. Interacts with HDAC1; this interaction is enhanced in the presence of PWWP2B.|||Cytoplasm|||Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.|||Nucleus|||spindle pole http://togogenome.org/gene/9595:CLNS1A ^@ http://purl.uniprot.org/uniprot/A0A2I2Z6E0|||http://purl.uniprot.org/uniprot/G3QKQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pICln (TC 1.A.47) family.|||Nucleus http://togogenome.org/gene/9595:RPS21 ^@ http://purl.uniprot.org/uniprot/A0A2I2YYA4|||http://purl.uniprot.org/uniprot/G3S5I5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS21 family.|||Component of the 40S small ribosomal subunit.|||Endoplasmic reticulum|||Rough endoplasmic reticulum|||cytosol http://togogenome.org/gene/9595:GPC5 ^@ http://purl.uniprot.org/uniprot/G3RGF7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/9595:BORCS5 ^@ http://purl.uniprot.org/uniprot/G3RZM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS5 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9595:CUEDC2 ^@ http://purl.uniprot.org/uniprot/G3QVR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUEDC2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:LOC101131628 ^@ http://purl.uniprot.org/uniprot/G3RRJ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9595:LYPLA2 ^@ http://purl.uniprot.org/uniprot/G3QNX0 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/9595:FUT8 ^@ http://purl.uniprot.org/uniprot/G3R0L8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 23 family.|||Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9595:UCMA ^@ http://purl.uniprot.org/uniprot/G3RE54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UCMA family.|||May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.|||extracellular matrix http://togogenome.org/gene/9595:GRAMD1A ^@ http://purl.uniprot.org/uniprot/G3RV31 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:LAMTOR4 ^@ http://purl.uniprot.org/uniprot/G3S8H2 ^@ Similarity ^@ Belongs to the LAMTOR4 family. http://togogenome.org/gene/9595:CAMLG ^@ http://purl.uniprot.org/uniprot/G3R3Y6 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells. http://togogenome.org/gene/9595:COLGALT2 ^@ http://purl.uniprot.org/uniprot/G3RC09 ^@ Similarity ^@ Belongs to the glycosyltransferase 25 family. http://togogenome.org/gene/9595:DIABLO ^@ http://purl.uniprot.org/uniprot/G3QRI5 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9595:TTC9 ^@ http://purl.uniprot.org/uniprot/G3QLS9 ^@ Similarity ^@ Belongs to the TTC9 family. http://togogenome.org/gene/9595:NAV3 ^@ http://purl.uniprot.org/uniprot/G3SIM3 ^@ Similarity ^@ Belongs to the Nav/unc-53 family. http://togogenome.org/gene/9595:AGPAT3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZNY2 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9595:ETV6 ^@ http://purl.uniprot.org/uniprot/G3QGQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9595:CHRNB2 ^@ http://purl.uniprot.org/uniprot/G3QW49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9595:CDK8 ^@ http://purl.uniprot.org/uniprot/G3QUM8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:MED20 ^@ http://purl.uniprot.org/uniprot/G3RJE7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 20 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9595:AP4S1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y3P3|||http://purl.uniprot.org/uniprot/G3QL05 ^@ Similarity ^@ Belongs to the adaptor complexes small subunit family. http://togogenome.org/gene/9595:NXT1 ^@ http://purl.uniprot.org/uniprot/G3R9X8 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/9595:TGS1 ^@ http://purl.uniprot.org/uniprot/G3QZW2 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family. http://togogenome.org/gene/9595:DDB1 ^@ http://purl.uniprot.org/uniprot/G3QN74 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DDB1 family.|||Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock.|||Component of the UV-DDB complex.|||Nucleus|||The core of the protein consists of three WD40 beta-propeller domains. http://togogenome.org/gene/9595:ABCG2 ^@ http://purl.uniprot.org/uniprot/G3QHY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/9595:TYW3 ^@ http://purl.uniprot.org/uniprot/G3RCV6 ^@ Function|||Similarity ^@ Belongs to the TYW3 family.|||Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. http://togogenome.org/gene/9595:SLC16A13 ^@ http://purl.uniprot.org/uniprot/G3QG09 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:VGLL4 ^@ http://purl.uniprot.org/uniprot/A0A2I2YTG3|||http://purl.uniprot.org/uniprot/A0A2I2ZKA6|||http://purl.uniprot.org/uniprot/G3QLS5 ^@ Function|||Similarity ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs. http://togogenome.org/gene/9595:PCSK2 ^@ http://purl.uniprot.org/uniprot/G3QWE4 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9595:PLA2G12A ^@ http://purl.uniprot.org/uniprot/A0A2I2ZUU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Secreted http://togogenome.org/gene/9595:NCBP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1G5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRM NCBP2 family.|||Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.|||Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.|||Nucleus http://togogenome.org/gene/9595:FZD10 ^@ http://purl.uniprot.org/uniprot/A0A2I2YWP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:LOC109028282 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZES0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:DDI1 ^@ http://purl.uniprot.org/uniprot/G3RAE7 ^@ Similarity ^@ Belongs to the DDI1 family. http://togogenome.org/gene/9595:CASTOR1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z0D1|||http://purl.uniprot.org/uniprot/G3QW74 ^@ Similarity ^@ Belongs to the GATS family. http://togogenome.org/gene/9595:RBM8A ^@ http://purl.uniprot.org/uniprot/A0A2I2ZK34 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RBM8A family.|||Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.|||Cytoplasm|||Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.|||Nucleus|||Nucleus speckle http://togogenome.org/gene/9595:NDUFA5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TIY8|||http://purl.uniprot.org/uniprot/Q0MQA1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA5 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:XIRP1 ^@ http://purl.uniprot.org/uniprot/G3RKB7 ^@ Domain|||Function|||Similarity ^@ Belongs to the Xin family.|||Protects actin filaments from depolymerization.|||Xin repeats bind F-actin. http://togogenome.org/gene/9595:PDE1C ^@ http://purl.uniprot.org/uniprot/A0A2I2YMV7|||http://purl.uniprot.org/uniprot/A0A2I2ZTC6 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9595:NSUN7 ^@ http://purl.uniprot.org/uniprot/A0A2I2YXN1 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:CAPN10 ^@ http://purl.uniprot.org/uniprot/G3QGL4 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9595:DHRS11 ^@ http://purl.uniprot.org/uniprot/A0A2I2YLK8|||http://purl.uniprot.org/uniprot/G3QY64 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9595:SLC4A3 ^@ http://purl.uniprot.org/uniprot/G3QRZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:AAR2 ^@ http://purl.uniprot.org/uniprot/G3RWS2 ^@ Function|||Similarity ^@ Belongs to the AAR2 family.|||Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. http://togogenome.org/gene/9595:CNTN1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YYD1|||http://purl.uniprot.org/uniprot/A0A2I2Z2F5 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. Contactin family. http://togogenome.org/gene/9595:PITX1 ^@ http://purl.uniprot.org/uniprot/G3QQ87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9595:MYO6 ^@ http://purl.uniprot.org/uniprot/A0A2I2YUX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||clathrin-coated pit|||clathrin-coated vesicle|||filopodium|||microvillus|||ruffle membrane|||trans-Golgi network membrane http://togogenome.org/gene/9595:TGIF2 ^@ http://purl.uniprot.org/uniprot/G3R7Z0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:LAMC1 ^@ http://purl.uniprot.org/uniprot/G3S795 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||basement membrane http://togogenome.org/gene/9595:SLC25A43 ^@ http://purl.uniprot.org/uniprot/G3S648 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9595:PRSS12 ^@ http://purl.uniprot.org/uniprot/G3QK11 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.|||Secreted http://togogenome.org/gene/9595:LTBP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZQF7|||http://purl.uniprot.org/uniprot/G3R903 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9595:CREBL2 ^@ http://purl.uniprot.org/uniprot/G3SGG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. ATF subfamily.|||Nucleus http://togogenome.org/gene/9595:INTS12 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y4J6 ^@ Similarity|||Subunit ^@ Belongs to the Integrator subunit 12 family.|||Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12. http://togogenome.org/gene/9595:LOC101131208 ^@ http://purl.uniprot.org/uniprot/G3QTH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 6A family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9595:IMPG1 ^@ http://purl.uniprot.org/uniprot/G3S150 ^@ Subcellular Location Annotation ^@ interphotoreceptor matrix http://togogenome.org/gene/9595:AMIGO1 ^@ http://purl.uniprot.org/uniprot/G3S862 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. AMIGO family.|||Membrane http://togogenome.org/gene/9595:SH3RF1 ^@ http://purl.uniprot.org/uniprot/G3QD49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SH3RF family.|||lamellipodium|||perinuclear region|||trans-Golgi network http://togogenome.org/gene/9595:LOC101134640 ^@ http://purl.uniprot.org/uniprot/G3RIU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9595:TGFBI ^@ http://purl.uniprot.org/uniprot/G3R261 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9595:CLDND2 ^@ http://purl.uniprot.org/uniprot/G3RFQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/9595:CRELD1 ^@ http://purl.uniprot.org/uniprot/G3RNI8 ^@ Caution|||Similarity ^@ Belongs to the CRELD family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:ACMSD ^@ http://purl.uniprot.org/uniprot/G3R2J5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.|||Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.|||Monomer. http://togogenome.org/gene/9595:TIGD6 ^@ http://purl.uniprot.org/uniprot/G3R0M8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SLC35E1 ^@ http://purl.uniprot.org/uniprot/G3RJR7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:CCN5 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZRV7 ^@ Similarity ^@ Belongs to the CCN family. http://togogenome.org/gene/9595:GRPEL1 ^@ http://purl.uniprot.org/uniprot/G3RJT9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GrpE family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion matrix http://togogenome.org/gene/9595:DRGX ^@ http://purl.uniprot.org/uniprot/G3QYQ5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:LOC101134814 ^@ http://purl.uniprot.org/uniprot/G3S4D2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9595:LARP7 ^@ http://purl.uniprot.org/uniprot/G3SFI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LARP7 family.|||nucleoplasm http://togogenome.org/gene/9595:ATG9B ^@ http://purl.uniprot.org/uniprot/G3RL06 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.|||Preautophagosomal structure membrane http://togogenome.org/gene/9595:LOC101148389 ^@ http://purl.uniprot.org/uniprot/G3RUZ8 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9595:CCNJ ^@ http://purl.uniprot.org/uniprot/G3QT91 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9595:USP13 ^@ http://purl.uniprot.org/uniprot/G3SKD8 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9595:DNER ^@ http://purl.uniprot.org/uniprot/G3RFZ4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:LHFPL6 ^@ http://purl.uniprot.org/uniprot/G3SAU7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:AK2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y1Z5|||http://purl.uniprot.org/uniprot/A0A2I2ZP83 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Belongs to the adenylate kinase family. AK2 subfamily.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Mitochondrion intermembrane space|||Monomer. http://togogenome.org/gene/9595:KCNMB4 ^@ http://purl.uniprot.org/uniprot/G3RAE5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KCNMB (TC 8.A.14.1) family.|||Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.|||Membrane|||N-glycosylated.|||Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. http://togogenome.org/gene/9595:NKG7 ^@ http://purl.uniprot.org/uniprot/G3RFP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/9595:SLC1A1 ^@ http://purl.uniprot.org/uniprot/G3QDE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9595:PEX7 ^@ http://purl.uniprot.org/uniprot/G3QJX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat peroxin-7 family.|||Peroxisome matrix|||cytosol http://togogenome.org/gene/9595:ANKRD13D ^@ http://purl.uniprot.org/uniprot/G3R6R1 ^@ Function|||Subcellular Location Annotation ^@ Endosome|||Late endosome|||Membrane|||Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. http://togogenome.org/gene/9595:LOC101124317 ^@ http://purl.uniprot.org/uniprot/G3RPV0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:CFL2 ^@ http://purl.uniprot.org/uniprot/G3QVF0 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. http://togogenome.org/gene/9595:DEFB135 ^@ http://purl.uniprot.org/uniprot/G3QZ08 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9595:RPS14 ^@ http://purl.uniprot.org/uniprot/A0A2I2YH05 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/9595:PPP1CC ^@ http://purl.uniprot.org/uniprot/A0A2I2ZXW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family. PP-1 subfamily.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9595:GNPNAT1 ^@ http://purl.uniprot.org/uniprot/G3SFH5 ^@ Similarity|||Subunit ^@ Belongs to the acetyltransferase family. GNA1 subfamily.|||Homodimer. http://togogenome.org/gene/9595:LYNX1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z8F6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:GTPBP3 ^@ http://purl.uniprot.org/uniprot/G3RHS2|||http://purl.uniprot.org/uniprot/G3S773 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. http://togogenome.org/gene/9595:LOC101154372 ^@ http://purl.uniprot.org/uniprot/G3QJ38 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:ZER1 ^@ http://purl.uniprot.org/uniprot/G3R9I9 ^@ Similarity ^@ Belongs to the zyg-11 family. http://togogenome.org/gene/9595:DHX58 ^@ http://purl.uniprot.org/uniprot/G3QRT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/9595:CCNYL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y7M7|||http://purl.uniprot.org/uniprot/A0A2I2Z0Z9 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin Y subfamily. http://togogenome.org/gene/9595:ITGB6 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y7Z0|||http://purl.uniprot.org/uniprot/G3R1W1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:GABRQ ^@ http://purl.uniprot.org/uniprot/G3RJ63 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9595:PLN ^@ http://purl.uniprot.org/uniprot/A0A2I2ZQD3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phospholamban family.|||Endoplasmic reticulum membrane|||Homopentamer.|||Membrane|||Mitochondrion membrane|||Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/9595:UMPS ^@ http://purl.uniprot.org/uniprot/G3RTQ7 ^@ Similarity ^@ In the C-terminal section; belongs to the OMP decarboxylase family.|||In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/9595:SLC26A2 ^@ http://purl.uniprot.org/uniprot/G3QE35 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane|||Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development. Mediates electroneutral anion exchange of sulfate ions for oxalate ions, sulfate and oxalate ions for chloride and/or hydroxyl ions and chloride ions for bromide, iodide and nitrate ions. The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange. Essential for chondrocyte proliferation, differentiation and cell size expansion. http://togogenome.org/gene/9595:ZUP1 ^@ http://purl.uniprot.org/uniprot/G3RKV6 ^@ Similarity|||Subunit ^@ Belongs to the peptidase C78 family. ZUFSP subfamily.|||Interacts with RPA1 and RPA2. http://togogenome.org/gene/9595:RIC8B ^@ http://purl.uniprot.org/uniprot/A0A2I2YTZ8|||http://purl.uniprot.org/uniprot/A0A2I2YYP3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the synembryn family.|||Cytoplasm|||Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.|||Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. http://togogenome.org/gene/9595:CA12 ^@ http://purl.uniprot.org/uniprot/G3QI60 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9595:PFN2 ^@ http://purl.uniprot.org/uniprot/G3QW12 ^@ Similarity ^@ Belongs to the profilin family. http://togogenome.org/gene/9595:CRISP1 ^@ http://purl.uniprot.org/uniprot/G3R4Q7 ^@ Caution|||Similarity ^@ Belongs to the CRISP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:RGS7BP ^@ http://purl.uniprot.org/uniprot/G3R6X3 ^@ Similarity ^@ Belongs to the RGS7BP/RGS9BP family. http://togogenome.org/gene/9595:POU5F1 ^@ http://purl.uniprot.org/uniprot/G3S2Z8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/9595:MECOM ^@ http://purl.uniprot.org/uniprot/G3RBC7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:CSAD ^@ http://purl.uniprot.org/uniprot/A0A2I2ZNE2 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/9595:BCAR1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YVQ0|||http://purl.uniprot.org/uniprot/G3R533|||http://purl.uniprot.org/uniprot/G3RT25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAS family.|||focal adhesion http://togogenome.org/gene/9595:LOC101147293 ^@ http://purl.uniprot.org/uniprot/G3RBS9|||http://purl.uniprot.org/uniprot/G3RW52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MOZART2 family.|||centrosome|||spindle http://togogenome.org/gene/9595:PITHD1 ^@ http://purl.uniprot.org/uniprot/G3QNW5 ^@ Similarity ^@ Belongs to the PITHD1 family. http://togogenome.org/gene/9595:DEFB118 ^@ http://purl.uniprot.org/uniprot/A4H220 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Host defense peptide that exhibits antimicrobial activity against both Gram-negative bacteria, such as E.coli and S.typhimurium, and Gram-positive bacteria, such as S.aureus and B.subtilis (By similarity). Inhibits cell adhesion of E.coli on intestinal epithelial enterocytes (By similarity). Causes rapid permeabilization of both the outer and inner membrane of E.coli, leading to morphological alterations on the bacterial surface (By similarity). Binds to bacterial lipopolysaccharides (LPS) with high affinity, and may thereby be involved in immunoregulation through LPS neutralization (By similarity). May contribute to epididymal innate immunity and protect the sperm against attack by microorganisms (By similarity).|||Secreted|||The three-dimensional structure formed by the three intramolecular disulfide bridges is indispensable for antimicrobial activity. http://togogenome.org/gene/9595:DDX21 ^@ http://purl.uniprot.org/uniprot/G3QQU4 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily. http://togogenome.org/gene/9595:RORB ^@ http://purl.uniprot.org/uniprot/G3S875 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9595:MTRF1 ^@ http://purl.uniprot.org/uniprot/G3QJA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Mitochondrion http://togogenome.org/gene/9595:PON3 ^@ http://purl.uniprot.org/uniprot/G3RBS0 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit.|||Glycosylated. http://togogenome.org/gene/9595:GSK3A ^@ http://purl.uniprot.org/uniprot/G3QPQ5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. http://togogenome.org/gene/9595:SMIM12 ^@ http://purl.uniprot.org/uniprot/A0A2I2YHE2|||http://purl.uniprot.org/uniprot/A0A2I2Z1S9 ^@ Similarity ^@ Belongs to the SMIM12 family. http://togogenome.org/gene/9595:PCBD1 ^@ http://purl.uniprot.org/uniprot/G3RDN1 ^@ Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family. http://togogenome.org/gene/9595:SLC25A19 ^@ http://purl.uniprot.org/uniprot/G3S981 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9595:ALB ^@ http://purl.uniprot.org/uniprot/G3S791 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9595:RPL37A ^@ http://purl.uniprot.org/uniprot/G3RFT4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL43 family. http://togogenome.org/gene/9595:EBF1 ^@ http://purl.uniprot.org/uniprot/G3QCT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COE family.|||Nucleus http://togogenome.org/gene/9595:SLC27A2 ^@ http://purl.uniprot.org/uniprot/G3QTE5 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9595:THRB ^@ http://purl.uniprot.org/uniprot/G3QWF5|||http://purl.uniprot.org/uniprot/G3S6W6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9595:PTX4 ^@ http://purl.uniprot.org/uniprot/G3SAG7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:EIF1AD ^@ http://purl.uniprot.org/uniprot/G3R7Z8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the EIF1AD family.|||Interacts with GAPDH and STAT1.|||Plays a role into cellular response to oxidative stress. Decreases cell proliferation. http://togogenome.org/gene/9595:CEPT1 ^@ http://purl.uniprot.org/uniprot/G3R2A9 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/9595:PARP15 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZPY1|||http://purl.uniprot.org/uniprot/G3S4Z7 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9595:S100A16 ^@ http://purl.uniprot.org/uniprot/G3S962 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9595:DENND5A ^@ http://purl.uniprot.org/uniprot/A0A2I2ZCJ1|||http://purl.uniprot.org/uniprot/G3R4D5 ^@ Caution|||Similarity ^@ Belongs to the RAB6IP1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:PSMD4 ^@ http://purl.uniprot.org/uniprot/G3QN77 ^@ Similarity ^@ Belongs to the proteasome subunit S5A family. http://togogenome.org/gene/9595:AHCYL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1F3|||http://purl.uniprot.org/uniprot/G3R806 ^@ Similarity ^@ Belongs to the adenosylhomocysteinase family. http://togogenome.org/gene/9595:BARX1 ^@ http://purl.uniprot.org/uniprot/G3R4K0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:NIPAL2 ^@ http://purl.uniprot.org/uniprot/G3QIX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9595:HAPSTR2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YQ82 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:LOC101152881 ^@ http://purl.uniprot.org/uniprot/G3SK33 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9595:CBX6 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y460 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:CLDN20 ^@ http://purl.uniprot.org/uniprot/G3QDH2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9595:ACOX2 ^@ http://purl.uniprot.org/uniprot/G3RHE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/9595:LOC101125671 ^@ http://purl.uniprot.org/uniprot/G3SGJ4 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9595:IFITM2 ^@ http://purl.uniprot.org/uniprot/G3RRI8 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9595:MCM2 ^@ http://purl.uniprot.org/uniprot/G3RFX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Chromosome|||Nucleus http://togogenome.org/gene/9595:MPP4 ^@ http://purl.uniprot.org/uniprot/G3RGC7 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/9595:DUOXA2 ^@ http://purl.uniprot.org/uniprot/G3R7T2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DUOXA family.|||Membrane http://togogenome.org/gene/9595:CD1D ^@ http://purl.uniprot.org/uniprot/G3R7Y4 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9595:IL17F ^@ http://purl.uniprot.org/uniprot/G3QQN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/9595:EFNB1 ^@ http://purl.uniprot.org/uniprot/G3R3A6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:ERH ^@ http://purl.uniprot.org/uniprot/G3QPZ4 ^@ Function|||Similarity ^@ Belongs to the E(R) family.|||May have a role in the cell cycle. http://togogenome.org/gene/9595:B3GNT2 ^@ http://purl.uniprot.org/uniprot/G3RQS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:TFIP11 ^@ http://purl.uniprot.org/uniprot/G3QQN1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFP11/STIP family.|||Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.|||Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.|||Nucleus http://togogenome.org/gene/9595:TXNIP ^@ http://purl.uniprot.org/uniprot/G3R848 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9595:BAIAP3 ^@ http://purl.uniprot.org/uniprot/G3R7P0 ^@ Similarity ^@ Belongs to the unc-13 family. http://togogenome.org/gene/9595:MAST2 ^@ http://purl.uniprot.org/uniprot/G3RI07 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/9595:MAN1A2 ^@ http://purl.uniprot.org/uniprot/G3REE6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9595:VLDLR ^@ http://purl.uniprot.org/uniprot/A0A2I2ZM49|||http://purl.uniprot.org/uniprot/G3QG94 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:GUF1 ^@ http://purl.uniprot.org/uniprot/G3SBM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding elongation factor family. LepA subfamily.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Mitochondrion inner membrane|||Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. http://togogenome.org/gene/9595:CERT1 ^@ http://purl.uniprot.org/uniprot/G3QQS6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum|||Golgi apparatus http://togogenome.org/gene/9595:CACNG3 ^@ http://purl.uniprot.org/uniprot/G3QJX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane http://togogenome.org/gene/9595:GOSR2 ^@ http://purl.uniprot.org/uniprot/G3RYB1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOSR2 family.|||Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.|||Membrane http://togogenome.org/gene/9595:TP53RK ^@ http://purl.uniprot.org/uniprot/G3QI33 ^@ Similarity ^@ Belongs to the protein kinase superfamily. BUD32 family. http://togogenome.org/gene/9595:SLC30A7 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZEX1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Functions as a zinc transporter.|||Homooligomer.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9595:RNF175 ^@ http://purl.uniprot.org/uniprot/G3QYC3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:MRPL49 ^@ http://purl.uniprot.org/uniprot/A0A2I2YN15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL49 family.|||Mitochondrion http://togogenome.org/gene/9595:PGAP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YLW6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PGAP2 family.|||Interacts with PGAP2IP.|||Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface.|||Membrane http://togogenome.org/gene/9595:RET ^@ http://purl.uniprot.org/uniprot/G3QLZ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane|||Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. http://togogenome.org/gene/9595:ADGRG1 ^@ http://purl.uniprot.org/uniprot/G3QZE8|||http://purl.uniprot.org/uniprot/G3S7U6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Membrane raft|||Secreted http://togogenome.org/gene/9595:CFAP91 ^@ http://purl.uniprot.org/uniprot/G3R2Z4 ^@ Similarity ^@ Belongs to the CFAP91 family. http://togogenome.org/gene/9595:WIF1 ^@ http://purl.uniprot.org/uniprot/G3QJF3 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9595:ATP6V1E2 ^@ http://purl.uniprot.org/uniprot/G3R7D0 ^@ Similarity ^@ Belongs to the V-ATPase E subunit family. http://togogenome.org/gene/9595:LOC101127473 ^@ http://purl.uniprot.org/uniprot/G3RYZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:MAN2A2 ^@ http://purl.uniprot.org/uniprot/G3QYR7 ^@ Cofactor|||Similarity ^@ Belongs to the glycosyl hydrolase 38 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9595:ARMC1 ^@ http://purl.uniprot.org/uniprot/G3RPG2 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9595:TNS2 ^@ http://purl.uniprot.org/uniprot/G3RFX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTEN phosphatase protein family.|||focal adhesion http://togogenome.org/gene/9595:MCCC2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZT81 ^@ Similarity ^@ Belongs to the AccD/PCCB family. http://togogenome.org/gene/9595:HTRA2 ^@ http://purl.uniprot.org/uniprot/G3QU02 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/9595:KCNK10 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZIQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9595:GCK ^@ http://purl.uniprot.org/uniprot/A0A2I2ZDN4 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/9595:CASP5 ^@ http://purl.uniprot.org/uniprot/G3RI80 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9595:SPIN1 ^@ http://purl.uniprot.org/uniprot/G3QXB0 ^@ Similarity ^@ Belongs to the SPIN/STSY family. http://togogenome.org/gene/9595:IL36G ^@ http://purl.uniprot.org/uniprot/G3RIS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9595:PDS5A ^@ http://purl.uniprot.org/uniprot/G3QWM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDS5 family.|||Nucleus http://togogenome.org/gene/9595:GABRB3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YX51|||http://purl.uniprot.org/uniprot/G3R6H5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9595:HAPSTR1 ^@ http://purl.uniprot.org/uniprot/G3R5A4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:STAR ^@ http://purl.uniprot.org/uniprot/G3QSM4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ May interact with TSPO.|||Mitochondrion|||Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. http://togogenome.org/gene/9595:SH3BP4 ^@ http://purl.uniprot.org/uniprot/G3RCE8 ^@ Subcellular Location Annotation ^@ Nucleus|||Vesicle|||clathrin-coated pit|||clathrin-coated vesicle http://togogenome.org/gene/9595:MPP7 ^@ http://purl.uniprot.org/uniprot/G3RT21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||adherens junction|||tight junction http://togogenome.org/gene/9595:MYO16 ^@ http://purl.uniprot.org/uniprot/G3RLK0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9595:GNAT2 ^@ http://purl.uniprot.org/uniprot/G3RBX2 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9595:HRH2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y6Q5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:PRKCH ^@ http://purl.uniprot.org/uniprot/G3QZ70 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis.|||Cytoplasm|||Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-513 (activation loop of the kinase domain), Thr-656 (turn motif) and Ser-675 (hydrophobic region), need to be phosphorylated for its full activation. http://togogenome.org/gene/9595:ARAP2 ^@ http://purl.uniprot.org/uniprot/G3RS92 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:LOC101131222 ^@ http://purl.uniprot.org/uniprot/A0A2I2YR16|||http://purl.uniprot.org/uniprot/G3QH59 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.|||Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. http://togogenome.org/gene/9595:BECN2 ^@ http://purl.uniprot.org/uniprot/G3QYP8 ^@ Similarity ^@ Belongs to the beclin family. http://togogenome.org/gene/9595:HPDL ^@ http://purl.uniprot.org/uniprot/G3QL76 ^@ Cofactor|||Similarity ^@ Belongs to the 4HPPD family.|||Binds 1 Fe cation per subunit. http://togogenome.org/gene/9595:BYSL ^@ http://purl.uniprot.org/uniprot/G3SFZ0 ^@ Similarity ^@ Belongs to the bystin family. http://togogenome.org/gene/9595:PAF1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z5M9 ^@ Similarity ^@ Belongs to the PAF1 family. http://togogenome.org/gene/9595:FOXP4 ^@ http://purl.uniprot.org/uniprot/G3RJT8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:DIS3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y578|||http://purl.uniprot.org/uniprot/G3QUT3 ^@ Similarity ^@ Belongs to the RNR ribonuclease family. http://togogenome.org/gene/9595:MRPS27 ^@ http://purl.uniprot.org/uniprot/G3R553 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9595:TXLNB ^@ http://purl.uniprot.org/uniprot/G3QLE7 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/9595:LOC101123911 ^@ http://purl.uniprot.org/uniprot/G3RNK8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9595:DHX8 ^@ http://purl.uniprot.org/uniprot/G3SFV7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:CNKSR2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YLC8|||http://purl.uniprot.org/uniprot/A0A2I2Z1K2 ^@ Similarity ^@ Belongs to the CNKSR family. http://togogenome.org/gene/9595:NGRN ^@ http://purl.uniprot.org/uniprot/G3RT32 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the neugrin family.|||Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct.|||Mitochondrion membrane|||Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system. http://togogenome.org/gene/9595:GRIA2 ^@ http://purl.uniprot.org/uniprot/G3RAA1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9595:SPI1 ^@ http://purl.uniprot.org/uniprot/G3QUE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9595:IQSEC3 ^@ http://purl.uniprot.org/uniprot/G3S130 ^@ Similarity ^@ Belongs to the BRAG family. http://togogenome.org/gene/9595:GATAD1 ^@ http://purl.uniprot.org/uniprot/G3SJQ6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:LOC101142284 ^@ http://purl.uniprot.org/uniprot/G3R2J7 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9595:RPS6KA1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZKI3|||http://purl.uniprot.org/uniprot/G3QKB5|||http://purl.uniprot.org/uniprot/G3SI99 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9595:NUMBL ^@ http://purl.uniprot.org/uniprot/G3RTX6 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Plays a role in the process of neurogenesis. http://togogenome.org/gene/9595:ACKR3 ^@ http://purl.uniprot.org/uniprot/G3QNR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:AVPI1 ^@ http://purl.uniprot.org/uniprot/G3RMY3 ^@ Function ^@ May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling. http://togogenome.org/gene/9595:HPS3 ^@ http://purl.uniprot.org/uniprot/G3S9Z3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.|||Cytoplasm|||Involved in early stages of melanosome biogenesis and maturation. http://togogenome.org/gene/9595:FGF5 ^@ http://purl.uniprot.org/uniprot/A0A2I2YYH7|||http://purl.uniprot.org/uniprot/G3QKB9 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9595:CCR6 ^@ http://purl.uniprot.org/uniprot/A0A2I2YD51 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:DARS1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y6L3 ^@ Function|||Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. http://togogenome.org/gene/9595:TRAPPC3L ^@ http://purl.uniprot.org/uniprot/A0A2I2Y6L5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||Homodimer.|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||cis-Golgi network http://togogenome.org/gene/9595:LIG4 ^@ http://purl.uniprot.org/uniprot/G3S2K5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent DNA ligase family.|||Nucleus http://togogenome.org/gene/9595:POLR2L ^@ http://purl.uniprot.org/uniprot/G3R5H2 ^@ Similarity ^@ Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family. http://togogenome.org/gene/9595:GPAM ^@ http://purl.uniprot.org/uniprot/G3RLC0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPAT/DAPAT family.|||Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.|||Mitochondrion outer membrane http://togogenome.org/gene/9595:NNMT ^@ http://purl.uniprot.org/uniprot/G3QME2 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. http://togogenome.org/gene/9595:EIF3G ^@ http://purl.uniprot.org/uniprot/G3QRQ9 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit G family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of FRAP1 and RAPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts (via C-terminus) with AIFM1 (via N-terminus).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Phosphorylated. Phosphorylation is enhanced upon serum stimulation.|||RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA.|||perinuclear region http://togogenome.org/gene/9595:BCOR ^@ http://purl.uniprot.org/uniprot/G3RG00 ^@ Similarity ^@ Belongs to the BCOR family. http://togogenome.org/gene/9595:TMEM263 ^@ http://purl.uniprot.org/uniprot/G3S3B8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM263 family.|||Membrane http://togogenome.org/gene/9595:BLOC1S5 ^@ http://purl.uniprot.org/uniprot/A0A2I2YA28 ^@ Function|||Similarity ^@ Belongs to the BLOC1S5 family.|||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). http://togogenome.org/gene/9595:CALCR ^@ http://purl.uniprot.org/uniprot/G3SDU9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Interacts with GPRASP2.|||Membrane http://togogenome.org/gene/9595:APPL2 ^@ http://purl.uniprot.org/uniprot/G3RBH7 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Endosome membrane|||Membrane|||Nucleus|||phagosome|||ruffle http://togogenome.org/gene/9595:HCRTR1 ^@ http://purl.uniprot.org/uniprot/G3RIJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:TPD52L2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YE13|||http://purl.uniprot.org/uniprot/A0A2I2ZJD9|||http://purl.uniprot.org/uniprot/A0A2I2ZKW7|||http://purl.uniprot.org/uniprot/G3QE72 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/9595:MED29 ^@ http://purl.uniprot.org/uniprot/G3QHI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 29 family.|||Nucleus http://togogenome.org/gene/9595:LOC101128133 ^@ http://purl.uniprot.org/uniprot/A4H211 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta-defensin family.|||Has antibacterial activity. Acts as a ligand for C-C chemokine receptor CCR2.|||Membrane|||Monomer. Interacts with CCR2 (via extracellular N-terminal region); this interaction may preferentially require specific tyrosine sulfation on CCR2.|||Secreted http://togogenome.org/gene/9595:GRM1 ^@ http://purl.uniprot.org/uniprot/G3RGA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:LOC101144264 ^@ http://purl.uniprot.org/uniprot/G3R156 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9595:SYT15 ^@ http://purl.uniprot.org/uniprot/G3RX04|||http://purl.uniprot.org/uniprot/G3RZG6 ^@ Similarity ^@ Belongs to the synaptotagmin family. http://togogenome.org/gene/9595:EEF1G ^@ http://purl.uniprot.org/uniprot/G3S0A9 ^@ Function|||Subunit ^@ EF-1 is composed of four subunits: alpha, beta, delta, and gamma.|||Probably plays a role in anchoring the complex to other cellular components. http://togogenome.org/gene/9595:COX5A ^@ http://purl.uniprot.org/uniprot/A0A2I2YSZ5|||http://purl.uniprot.org/uniprot/B0VYX3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 5A family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Interacts with AFG1L (By similarity). Interacts with RAB5IF (By similarity).|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:UTP6 ^@ http://purl.uniprot.org/uniprot/G3RCL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP6 family.|||nucleolus http://togogenome.org/gene/9595:FGF16 ^@ http://purl.uniprot.org/uniprot/G3QIJ1 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9595:METTL4 ^@ http://purl.uniprot.org/uniprot/G3QF59 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/9595:LCN1 ^@ http://purl.uniprot.org/uniprot/G3QM49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/9595:PIERCE2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YXM8 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.|||cilium axoneme http://togogenome.org/gene/9595:PAIP2B ^@ http://purl.uniprot.org/uniprot/A0A2I2YN04 ^@ Similarity ^@ Belongs to the PAIP2 family. http://togogenome.org/gene/9595:INHBC ^@ http://purl.uniprot.org/uniprot/G3S8C9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/9595:PSENEN ^@ http://purl.uniprot.org/uniprot/G3RKY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PEN-2 family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9595:TIMM21 ^@ http://purl.uniprot.org/uniprot/G3RIN9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM21 family.|||Component of the TIM23 complex.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion membrane|||Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes. http://togogenome.org/gene/9595:KCNN3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZL41|||http://purl.uniprot.org/uniprot/G3S7U0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:PARD6G ^@ http://purl.uniprot.org/uniprot/A0A2I2YCP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAR6 family.|||Cytoplasm|||tight junction http://togogenome.org/gene/9595:FAM210A ^@ http://purl.uniprot.org/uniprot/G3QK48 ^@ Similarity ^@ Belongs to the FAM210 family. http://togogenome.org/gene/9595:TRIM67 ^@ http://purl.uniprot.org/uniprot/G3QLM3 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9595:CNOT10 ^@ http://purl.uniprot.org/uniprot/A0A2I2YIL4|||http://purl.uniprot.org/uniprot/G3QD61|||http://purl.uniprot.org/uniprot/G3RPD6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT10 family.|||Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:GASK1A ^@ http://purl.uniprot.org/uniprot/G3QEK9 ^@ Similarity ^@ Belongs to the GASK family. http://togogenome.org/gene/9595:EEF1D ^@ http://purl.uniprot.org/uniprot/A0A2I2Y439|||http://purl.uniprot.org/uniprot/A0A2I2YE77 ^@ Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family. http://togogenome.org/gene/9595:AGPAT2 ^@ http://purl.uniprot.org/uniprot/G3S699 ^@ Domain|||Function|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/9595:SNRNP27 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y8F3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNUT3 family.|||May play a role in mRNA splicing.|||Nucleus|||Part of a tri-snRNP complex. http://togogenome.org/gene/9595:METTL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YEB8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.|||Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.|||Forms a complex with WDR4.|||Nucleus|||Phosphorylation at Ser-52 inactivates its catalytic activity but does not affect the interaction with WDR4. http://togogenome.org/gene/9595:TRMT6 ^@ http://purl.uniprot.org/uniprot/G3QZT5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRM6/GCD10 family.|||Heterotetramer.|||Nucleus|||Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. http://togogenome.org/gene/9595:CAPZA3 ^@ http://purl.uniprot.org/uniprot/G3RLE1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/9595:TMED6 ^@ http://purl.uniprot.org/uniprot/G3QXM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:SYN3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y534 ^@ Similarity ^@ Belongs to the synapsin family. http://togogenome.org/gene/9595:BRPF3 ^@ http://purl.uniprot.org/uniprot/G3RC63 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:DNAJC25 ^@ http://purl.uniprot.org/uniprot/G3R9K7 ^@ Similarity ^@ Belongs to the DNAJC25 family. http://togogenome.org/gene/9595:AK5 ^@ http://purl.uniprot.org/uniprot/G3REZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylate kinase family.|||Cytoplasm http://togogenome.org/gene/9595:LOC101131991 ^@ http://purl.uniprot.org/uniprot/G3RCZ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9595:TTC4 ^@ http://purl.uniprot.org/uniprot/G3QRP6 ^@ Similarity ^@ Belongs to the TTC4 family. http://togogenome.org/gene/9595:CXCL9 ^@ http://purl.uniprot.org/uniprot/G3QPL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9595:RELL1 ^@ http://purl.uniprot.org/uniprot/G3RG41 ^@ Similarity ^@ Belongs to the RELT family. http://togogenome.org/gene/9595:DNM3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YL61|||http://purl.uniprot.org/uniprot/G3R025 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/9595:FGD3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YN64|||http://purl.uniprot.org/uniprot/G3R0M3 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9595:MYF5 ^@ http://purl.uniprot.org/uniprot/G3QNZ9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.|||Nucleus http://togogenome.org/gene/9595:SRPX2 ^@ http://purl.uniprot.org/uniprot/G3R3E3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:MANEAL ^@ http://purl.uniprot.org/uniprot/A0A2I2YYZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 99 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:TALDO1 ^@ http://purl.uniprot.org/uniprot/G3R5A9 ^@ Function|||Similarity ^@ Belongs to the transaldolase family. Type 1 subfamily.|||Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate. http://togogenome.org/gene/9595:ALX4 ^@ http://purl.uniprot.org/uniprot/G3RED1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:TMTC4 ^@ http://purl.uniprot.org/uniprot/G3R9Z8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/9595:RAB9B ^@ http://purl.uniprot.org/uniprot/G3R246 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||phagosome membrane http://togogenome.org/gene/9595:KRT3 ^@ http://purl.uniprot.org/uniprot/G3QMP4 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:QSOX1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZYR1|||http://purl.uniprot.org/uniprot/G3R3B5 ^@ Function|||Similarity ^@ Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.|||Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. http://togogenome.org/gene/9595:PRM2 ^@ http://purl.uniprot.org/uniprot/G3QEH9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the protamine P2 family.|||Interacts with TDRP.|||Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. http://togogenome.org/gene/9595:APOC2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z3W8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the apolipoprotein C2 family.|||Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase.|||Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing.|||Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma.|||Secreted http://togogenome.org/gene/9595:CCDC167 ^@ http://purl.uniprot.org/uniprot/G3QSA7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:UIMC1 ^@ http://purl.uniprot.org/uniprot/G3RLL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAP80 family.|||Nucleus http://togogenome.org/gene/9595:TSPAN15 ^@ http://purl.uniprot.org/uniprot/G3QXQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9595:CSK ^@ http://purl.uniprot.org/uniprot/G3R6C9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9595:FAM20B ^@ http://purl.uniprot.org/uniprot/G3QJ63 ^@ Similarity ^@ Belongs to the FAM20 family. http://togogenome.org/gene/9595:PLPPR1 ^@ http://purl.uniprot.org/uniprot/G3RUV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9595:RPL28 ^@ http://purl.uniprot.org/uniprot/A0A2I2YY03|||http://purl.uniprot.org/uniprot/G3SBX2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL28 family. http://togogenome.org/gene/9595:TM4SF18 ^@ http://purl.uniprot.org/uniprot/G3QIU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9595:LPCAT1 ^@ http://purl.uniprot.org/uniprot/G3RHY4 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9595:SEC13 ^@ http://purl.uniprot.org/uniprot/G3R3T3|||http://purl.uniprot.org/uniprot/G3SAN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||Lysosome membrane http://togogenome.org/gene/9595:PTGES3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZAY2|||http://purl.uniprot.org/uniprot/A0A2I2ZT10 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the p23/wos2 family.|||Cytoplasm|||Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation.|||Forms a complex with HSP70, HSP90 and other chaperones. http://togogenome.org/gene/9595:BCLAF1 ^@ http://purl.uniprot.org/uniprot/G3QHH1|||http://purl.uniprot.org/uniprot/G3SDE6 ^@ Similarity ^@ Belongs to the BCLAF1/THRAP3 family. http://togogenome.org/gene/9595:SLC2A6 ^@ http://purl.uniprot.org/uniprot/G3RA13 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/9595:LOC101131791 ^@ http://purl.uniprot.org/uniprot/G3RL79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9595:PRR23C ^@ http://purl.uniprot.org/uniprot/A0A2I2YPA4 ^@ Similarity ^@ Belongs to the PRR23 family. http://togogenome.org/gene/9595:MMP12 ^@ http://purl.uniprot.org/uniprot/G3RMX3 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9595:PIK3C2A ^@ http://purl.uniprot.org/uniprot/G3RRS8 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9595:LOC101128279 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZGA3 ^@ Similarity ^@ Belongs to the cornifin (SPRR) family. http://togogenome.org/gene/9595:EDA2R ^@ http://purl.uniprot.org/uniprot/G3SBP4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:TCF7L1 ^@ http://purl.uniprot.org/uniprot/G3QZP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCF/LEF family.|||Nucleus http://togogenome.org/gene/9595:AFP ^@ http://purl.uniprot.org/uniprot/G3QZW5 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9595:RNF7 ^@ http://purl.uniprot.org/uniprot/G3QHH4 ^@ Similarity ^@ Belongs to the RING-box family. http://togogenome.org/gene/9595:APMAP ^@ http://purl.uniprot.org/uniprot/G3QG13 ^@ Similarity ^@ Belongs to the strictosidine synthase family. http://togogenome.org/gene/9595:EFNA5 ^@ http://purl.uniprot.org/uniprot/G3QDP0|||http://purl.uniprot.org/uniprot/G3SHR8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:SLC30A9 ^@ http://purl.uniprot.org/uniprot/G3QHK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Endoplasmic reticulum|||Membrane|||Mitochondrion membrane|||Nucleus http://togogenome.org/gene/9595:PPP2R5D ^@ http://purl.uniprot.org/uniprot/G3QWE9 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9595:LOC101126269 ^@ http://purl.uniprot.org/uniprot/G3RN95 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9595:P4HA2 ^@ http://purl.uniprot.org/uniprot/G3SJ87 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9595:CHD9 ^@ http://purl.uniprot.org/uniprot/G3RS86 ^@ Similarity ^@ Belongs to the SNF2/RAD54 helicase family. http://togogenome.org/gene/9595:REXO2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YJB0|||http://purl.uniprot.org/uniprot/G3S0H2 ^@ Similarity ^@ Belongs to the oligoribonuclease family. http://togogenome.org/gene/9595:UBE4A ^@ http://purl.uniprot.org/uniprot/A0A2I2ZD19 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin conjugation factor E4 family.|||Cytoplasm|||The U-box domain is required for the ubiquitin protein ligase activity.|||Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. http://togogenome.org/gene/9595:LOC101137052 ^@ http://purl.uniprot.org/uniprot/G3R8D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:DEDD ^@ http://purl.uniprot.org/uniprot/A0A2I2YKS2 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9595:ARPC3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y8K6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC3 family.|||Component of the Arp2/3 complex.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton http://togogenome.org/gene/9595:SLC2A2 ^@ http://purl.uniprot.org/uniprot/G3SES5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:TNFRSF10C ^@ http://purl.uniprot.org/uniprot/A0A2I2ZU78 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:TIMM8B ^@ http://purl.uniprot.org/uniprot/A0A2I2Z2U1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9595:SLC41A1 ^@ http://purl.uniprot.org/uniprot/G3RAG6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/9595:ZSCAN5B ^@ http://purl.uniprot.org/uniprot/G3RDX7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:NFRKB ^@ http://purl.uniprot.org/uniprot/G3RH61 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:IFI35 ^@ http://purl.uniprot.org/uniprot/G3R0I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NMI family.|||Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/9595:SLC2A11 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZBH9|||http://purl.uniprot.org/uniprot/G3R8K0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Cell membrane http://togogenome.org/gene/9595:CWF19L2 ^@ http://purl.uniprot.org/uniprot/G3QCV0 ^@ Similarity ^@ Belongs to the CWF19 family. http://togogenome.org/gene/9595:RXFP4 ^@ http://purl.uniprot.org/uniprot/G3SKU7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:SLC17A8 ^@ http://purl.uniprot.org/uniprot/G3RKY2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:XRN1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YLX7|||http://purl.uniprot.org/uniprot/G3QYF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 5'-3' exonuclease family.|||Cytoplasm http://togogenome.org/gene/9595:LYAR ^@ http://purl.uniprot.org/uniprot/G3RB50 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:LOC101141136 ^@ http://purl.uniprot.org/uniprot/G3SCC9 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9595:SMU1 ^@ http://purl.uniprot.org/uniprot/G3RFS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SMU1 family.|||Nucleus speckle http://togogenome.org/gene/9595:GBA2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YRQ7|||http://purl.uniprot.org/uniprot/G3QWP2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the non-lysosomal glucosylceramidase family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. http://togogenome.org/gene/9595:FAM162A ^@ http://purl.uniprot.org/uniprot/G3SB09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0389 family.|||Membrane http://togogenome.org/gene/9595:ICOS ^@ http://purl.uniprot.org/uniprot/G3RDY9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.|||Homodimer; disulfide-linked.|||Membrane http://togogenome.org/gene/9595:FAM8A1 ^@ http://purl.uniprot.org/uniprot/G3S6H9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:SLC31A1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZNZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9595:LOC101152080 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZQS3 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9595:GABRG2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YBS2|||http://purl.uniprot.org/uniprot/G3R6I5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9595:AMZ2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YNT0 ^@ Function|||Similarity ^@ Belongs to the peptidase M54 family.|||Probable zinc metalloprotease. http://togogenome.org/gene/9595:SCNN1B ^@ http://purl.uniprot.org/uniprot/G3QGR0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:LOC101134051 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZN27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:GNG3 ^@ http://purl.uniprot.org/uniprot/G3QL06 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9595:SAE1 ^@ http://purl.uniprot.org/uniprot/G3RBB9 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/9595:KIAA1191 ^@ http://purl.uniprot.org/uniprot/G3SJC8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P33MONOX family.|||Cytoplasm|||Interacts with NELFB, NOL12 and PRNP.|||Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth. http://togogenome.org/gene/9595:OSBPL3 ^@ http://purl.uniprot.org/uniprot/G3R4Q4 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9595:NUP107 ^@ http://purl.uniprot.org/uniprot/G3RA29 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nucleoporin Nup84/Nup107 family.|||Functions as a component of the nuclear pore complex (NPC).|||Nucleus membrane|||Part of the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/9595:SLC18A3 ^@ http://purl.uniprot.org/uniprot/G3SKN2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:DIMT1 ^@ http://purl.uniprot.org/uniprot/G3QIQ8 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. http://togogenome.org/gene/9595:GSTO1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YFL5|||http://purl.uniprot.org/uniprot/G3QQT9 ^@ Function|||Similarity ^@ Belongs to the GST superfamily. Omega family.|||Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). http://togogenome.org/gene/9595:SELP ^@ http://purl.uniprot.org/uniprot/G3QF58 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the selectin/LECAM family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:CHAC2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZG85 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.|||Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. http://togogenome.org/gene/9595:GPR158 ^@ http://purl.uniprot.org/uniprot/G3RIM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9595:STK39 ^@ http://purl.uniprot.org/uniprot/G3SH11 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. http://togogenome.org/gene/9595:ITGA9 ^@ http://purl.uniprot.org/uniprot/G3RB97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9595:LEF1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y353|||http://purl.uniprot.org/uniprot/A0A2I2ZGI1|||http://purl.uniprot.org/uniprot/G3S1G4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCF/LEF family.|||Nucleus http://togogenome.org/gene/9595:AADAC ^@ http://purl.uniprot.org/uniprot/G3QIK6 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/9595:MRPL9 ^@ http://purl.uniprot.org/uniprot/G3QHN7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family. http://togogenome.org/gene/9595:RHPN1 ^@ http://purl.uniprot.org/uniprot/G3RN00 ^@ Similarity ^@ Belongs to the RHPN family. http://togogenome.org/gene/9595:RNF141 ^@ http://purl.uniprot.org/uniprot/G3QKU0 ^@ Function ^@ May be involved in spermatogenesis. http://togogenome.org/gene/9595:TRMT1L ^@ http://purl.uniprot.org/uniprot/G3R7Y9 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.|||May play a role in motor coordination and exploratory behavior. http://togogenome.org/gene/9595:GPRIN3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z279 ^@ Function ^@ May be involved in neurite outgrowth. http://togogenome.org/gene/9595:GLS ^@ http://purl.uniprot.org/uniprot/G3QX94|||http://purl.uniprot.org/uniprot/G3SB67 ^@ Similarity ^@ Belongs to the glutaminase family. http://togogenome.org/gene/9595:BID ^@ http://purl.uniprot.org/uniprot/G3R4T6 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2.|||Induces caspases and apoptosis. Counters the protective effect of BCL2.|||Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9595:FABP7 ^@ http://purl.uniprot.org/uniprot/A0A2I2YNI9|||http://purl.uniprot.org/uniprot/G3S7I0 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9595:SDE2 ^@ http://purl.uniprot.org/uniprot/G3R309 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SDE2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:CAND2 ^@ http://purl.uniprot.org/uniprot/G3QFC2 ^@ Similarity ^@ Belongs to the CAND family. http://togogenome.org/gene/9595:SLC9A8 ^@ http://purl.uniprot.org/uniprot/G3QHU1 ^@ Similarity ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. http://togogenome.org/gene/9595:MAF1 ^@ http://purl.uniprot.org/uniprot/G3QIW4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MAF1 family.|||Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.|||Nucleus http://togogenome.org/gene/9595:LOC101126119 ^@ http://purl.uniprot.org/uniprot/G3QWI7 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:KCNJ13 ^@ http://purl.uniprot.org/uniprot/G3R0D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9595:WNT8A ^@ http://purl.uniprot.org/uniprot/G3QNT0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9595:PDIK1L ^@ http://purl.uniprot.org/uniprot/G3RVD5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:LSM4 ^@ http://purl.uniprot.org/uniprot/G3RAW4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/9595:CIT ^@ http://purl.uniprot.org/uniprot/A0A2I2YXF8|||http://purl.uniprot.org/uniprot/G3RBB0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.|||Cytoplasm|||Plays a role in cytokinesis. Displays serine/threonine protein kinase activity. http://togogenome.org/gene/9595:PLPBP ^@ http://purl.uniprot.org/uniprot/G3RAS4 ^@ Function|||Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.|||Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6. http://togogenome.org/gene/9595:CAPZB ^@ http://purl.uniprot.org/uniprot/A0A2I2Z2V7|||http://purl.uniprot.org/uniprot/G3RPD0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the F-actin-capping protein beta subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit.|||cytoskeleton|||sarcomere http://togogenome.org/gene/9595:CHSY1 ^@ http://purl.uniprot.org/uniprot/G3R0R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9595:LCN2 ^@ http://purl.uniprot.org/uniprot/G3SEI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/9595:LOC101137932 ^@ http://purl.uniprot.org/uniprot/G3QDX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/9595:RPS28 ^@ http://purl.uniprot.org/uniprot/G3RU06 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/9595:CLDN1 ^@ http://purl.uniprot.org/uniprot/G3RDP5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9595:GC ^@ http://purl.uniprot.org/uniprot/G3REP7 ^@ Function|||Subcellular Location Annotation ^@ Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.|||Secreted http://togogenome.org/gene/9595:AURKA ^@ http://purl.uniprot.org/uniprot/G3QW90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.|||centrosome http://togogenome.org/gene/9595:CDH24 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z4R1 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:KRTCAP3 ^@ http://purl.uniprot.org/uniprot/G3QFH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM54 family.|||Membrane http://togogenome.org/gene/9595:TEX10 ^@ http://purl.uniprot.org/uniprot/G3QHL7 ^@ Similarity ^@ Belongs to the IPI1/TEX10 family. http://togogenome.org/gene/9595:CACNG5 ^@ http://purl.uniprot.org/uniprot/G3RZQ2 ^@ Similarity ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. http://togogenome.org/gene/9595:YOD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YDR5|||http://purl.uniprot.org/uniprot/G3QU72 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin. http://togogenome.org/gene/9595:NSG1 ^@ http://purl.uniprot.org/uniprot/G3R690 ^@ Similarity ^@ Belongs to the NSG family. http://togogenome.org/gene/9595:ST8SIA2 ^@ http://purl.uniprot.org/uniprot/G3R9X3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9595:TAF1B ^@ http://purl.uniprot.org/uniprot/G3QJP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRN7/TAF1B family.|||Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.|||nucleolus http://togogenome.org/gene/9595:HDAC10 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZGN8|||http://purl.uniprot.org/uniprot/A0A2I2ZMZ8|||http://purl.uniprot.org/uniprot/G3REU8 ^@ Similarity ^@ Belongs to the histone deacetylase family. HD type 2 subfamily. http://togogenome.org/gene/9595:SERPINB11 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZTW5 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9595:RCL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YDW0|||http://purl.uniprot.org/uniprot/G3RGD4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.|||Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.|||nucleolus http://togogenome.org/gene/9595:LAMA1 ^@ http://purl.uniprot.org/uniprot/G3RYE2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/9595:MMP15 ^@ http://purl.uniprot.org/uniprot/G3S700 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9595:MIS18A ^@ http://purl.uniprot.org/uniprot/G3QQ71 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.|||centromere http://togogenome.org/gene/9595:UVSSA ^@ http://purl.uniprot.org/uniprot/G3QQB0 ^@ Similarity ^@ Belongs to the UVSSA family. http://togogenome.org/gene/9595:ALDH4A1 ^@ http://purl.uniprot.org/uniprot/G3QS05 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9595:MRPL12 ^@ http://purl.uniprot.org/uniprot/G3R1R2 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL12 family. http://togogenome.org/gene/9595:PFKFB2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y745|||http://purl.uniprot.org/uniprot/A0A2I2ZII5 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/9595:AKR1B1 ^@ http://purl.uniprot.org/uniprot/G3R7U6 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9595:PPP1R1A ^@ http://purl.uniprot.org/uniprot/G3QZ87 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 1 family. http://togogenome.org/gene/9595:ABRACL ^@ http://purl.uniprot.org/uniprot/G3R0S3 ^@ Similarity ^@ Belongs to the costars family. http://togogenome.org/gene/9595:POLR1F ^@ http://purl.uniprot.org/uniprot/G3RU18 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPA43 RNA polymerase subunit family.|||DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/9595:SLC44A4 ^@ http://purl.uniprot.org/uniprot/G3R0T0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/9595:LAMTOR3 ^@ http://purl.uniprot.org/uniprot/G3QFN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR3 family.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/9595:ARF6 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z417 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||Cell membrane|||Cleavage furrow|||Endosome membrane|||Midbody ring|||Recycling endosome membrane|||filopodium membrane|||ruffle http://togogenome.org/gene/9595:LOC101133649 ^@ http://purl.uniprot.org/uniprot/P61638 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIIc family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Interacts with RAB5IF (By similarity).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:LOC101145420 ^@ http://purl.uniprot.org/uniprot/G3QEG5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:HSPA9 ^@ http://purl.uniprot.org/uniprot/G3RE43 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9595:NKAIN2 ^@ http://purl.uniprot.org/uniprot/G3R2K2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NKAIN family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ELOVL6 ^@ http://purl.uniprot.org/uniprot/G3QDA7 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL6 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||N-Glycosylated. http://togogenome.org/gene/9595:GALK1 ^@ http://purl.uniprot.org/uniprot/G3R272 ^@ Similarity ^@ Belongs to the GHMP kinase family. GalK subfamily. http://togogenome.org/gene/9595:MTTP ^@ http://purl.uniprot.org/uniprot/G3QDV8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:IP6K3 ^@ http://purl.uniprot.org/uniprot/G3RJJ9 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9595:UBA52 ^@ http://purl.uniprot.org/uniprot/A0A2I2YPT0 ^@ Similarity|||Subcellular Location Annotation ^@ Cytoplasm|||In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.|||In the N-terminal section; belongs to the ubiquitin family.|||Nucleus http://togogenome.org/gene/9595:GRM6 ^@ http://purl.uniprot.org/uniprot/G3R8K3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:LHX9 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1J5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:PTK2 ^@ http://purl.uniprot.org/uniprot/G3S1C3 ^@ Subcellular Location Annotation ^@ Cell membrane|||cell cortex|||focal adhesion http://togogenome.org/gene/9595:ERVW-1 ^@ http://purl.uniprot.org/uniprot/P61561 ^@ Domain|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the gamma type-C retroviral envelope protein family. HERV class-I W env subfamily.|||Cell membrane|||Endogenous envelope proteins may have kept, lost or modified their original function during evolution. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein (SU) mediates receptor recognition, while the transmembrane protein (TM) acts as a class I viral fusion protein. The protein may have at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of membranes (By similarity).|||Ortholog of the human HERV-W_7q21.2 envelope protein.|||Specific enzymatic cleavages in vivo yield mature proteins. Envelope glycoproteins are synthesized as an inactive precursor that is heavily N-glycosylated and processed likely by furin in the Golgi to yield the mature SU and TM proteins. The cleavage site between SU and TM requires the minimal sequence [KR]-X-[KR]-R (By similarity).|||The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins. Synthetic peptides derived from this relatively conserved sequence inhibit immune function in vitro and in vivo (By similarity).|||The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein (By similarity).|||The cytoplasmic region is essential for the fusiogenic function.|||The genome contains a high percentage of proviral-like elements, also called endogenous retroviruses (ERVs) that are the genomic traces of ancient infections of the germline by exogenous retroviruses. Although most of these elements are defective, some have conserved a functional envelope (env) gene, most probably diverted by the host for its benefit.|||The mature envelope protein (Env) consists of a trimer of SU-TM heterodimers attached probably by a labile interchain disulfide bond. Interacts with the C-type lectin CD209/DC-SIGN (By similarity).|||This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May recognize and induce fusion through binding of SLC1A4 and SLC1A5 (By similarity).|||Virion http://togogenome.org/gene/9595:ST6GALNAC4 ^@ http://purl.uniprot.org/uniprot/G3RFF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9595:TNFAIP1 ^@ http://purl.uniprot.org/uniprot/G3QPI7 ^@ Similarity ^@ Belongs to the BACURD family. http://togogenome.org/gene/9595:GTF2A2 ^@ http://purl.uniprot.org/uniprot/G3RVY6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 2 family.|||Nucleus|||TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. http://togogenome.org/gene/9595:PDK4 ^@ http://purl.uniprot.org/uniprot/G3QJ46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9595:SLC7A13 ^@ http://purl.uniprot.org/uniprot/G3QZK6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:ATP6V1E1 ^@ http://purl.uniprot.org/uniprot/G3RGC3 ^@ Similarity ^@ Belongs to the V-ATPase E subunit family. http://togogenome.org/gene/9595:LOC101148069 ^@ http://purl.uniprot.org/uniprot/G3R255 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cystatin family.|||Secreted http://togogenome.org/gene/9595:FAS ^@ http://purl.uniprot.org/uniprot/G3S9B2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane raft http://togogenome.org/gene/9595:ITPA ^@ http://purl.uniprot.org/uniprot/G3R067 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Cytoplasm|||Homodimer.|||Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. http://togogenome.org/gene/9595:NME7 ^@ http://purl.uniprot.org/uniprot/A0A2I2YP06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||cilium axoneme http://togogenome.org/gene/9595:KDM4B ^@ http://purl.uniprot.org/uniprot/G3R2U2|||http://purl.uniprot.org/uniprot/G3RR88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JHDM3 histone demethylase family.|||Nucleus http://togogenome.org/gene/9595:PLPPR5 ^@ http://purl.uniprot.org/uniprot/G3RQY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9595:ZNF24 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y5T7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:CHST3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZJP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/9595:TAF9B ^@ http://purl.uniprot.org/uniprot/G3QJ49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF9 family.|||Nucleus http://togogenome.org/gene/9595:RAB3D ^@ http://purl.uniprot.org/uniprot/A0A2I2ZMK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/9595:TMEM255A ^@ http://purl.uniprot.org/uniprot/A0A2I2ZM24|||http://purl.uniprot.org/uniprot/G3R472 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM255 family.|||Membrane http://togogenome.org/gene/9595:UBE2E2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZJ41 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9595:TM2D3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YIC7|||http://purl.uniprot.org/uniprot/G3R7H2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:GTF2A1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YC53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 1 family.|||Nucleus http://togogenome.org/gene/9595:PRMT7 ^@ http://purl.uniprot.org/uniprot/G3QGT5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.|||Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.|||Nucleus|||cytosol http://togogenome.org/gene/9595:IFNAR1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YH23 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II cytokine receptor family.|||Cell membrane|||Endosome|||Heterodimer with IFNAR2.|||Late endosome|||Lysosome|||Membrane|||Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway. http://togogenome.org/gene/9595:EMC6 ^@ http://purl.uniprot.org/uniprot/G3R352 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC6 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:DCST1 ^@ http://purl.uniprot.org/uniprot/G3RDD3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:DERL3 ^@ http://purl.uniprot.org/uniprot/G3QEY2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Membrane http://togogenome.org/gene/9595:KIF5B ^@ http://purl.uniprot.org/uniprot/G3RC75 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9595:PRR5L ^@ http://purl.uniprot.org/uniprot/G3R0M0 ^@ Similarity ^@ Belongs to the PROTOR family. http://togogenome.org/gene/9595:HGF ^@ http://purl.uniprot.org/uniprot/G3QLL7 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase S1 family. Plasminogen subfamily.|||Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. http://togogenome.org/gene/9595:FGF23 ^@ http://purl.uniprot.org/uniprot/G3QKE3 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9595:SH3PXD2A ^@ http://purl.uniprot.org/uniprot/A0A2I2YW67|||http://purl.uniprot.org/uniprot/A0A2I2ZS83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SH3PXD2 family.|||Cytoplasm http://togogenome.org/gene/9595:ACTN4 ^@ http://purl.uniprot.org/uniprot/A0A2I2YSG9|||http://purl.uniprot.org/uniprot/A0A2I2Z0A7|||http://purl.uniprot.org/uniprot/A0A2I2Z718 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/9595:B3GNT9 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZUA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:BTN1A1 ^@ http://purl.uniprot.org/uniprot/G3SBE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Membrane http://togogenome.org/gene/9595:IRF3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z8H4|||http://purl.uniprot.org/uniprot/A0A2I2ZG68|||http://purl.uniprot.org/uniprot/G3S7V6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:PRKX ^@ http://purl.uniprot.org/uniprot/A0A2I2YLR9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:NKX2-5 ^@ http://purl.uniprot.org/uniprot/G3RLM6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:RPRD1A ^@ http://purl.uniprot.org/uniprot/A0A2I2YFV1|||http://purl.uniprot.org/uniprot/G3QWP7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the RNA polymerase II complex.|||Belongs to the UPF0400 (RTT103) family.|||Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.|||Nucleus http://togogenome.org/gene/9595:FLNA ^@ http://purl.uniprot.org/uniprot/A0A2I2YQV4|||http://purl.uniprot.org/uniprot/G3QNL9 ^@ Similarity ^@ Belongs to the filamin family. http://togogenome.org/gene/9595:CDK14 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZU98 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:AGXT ^@ http://purl.uniprot.org/uniprot/G3RFG7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||Peroxisome http://togogenome.org/gene/9595:LOC101151369 ^@ http://purl.uniprot.org/uniprot/G3RAB3 ^@ Function|||Subcellular Location Annotation ^@ Anchoring filament protein which is a component of the basement membrane zone.|||basement membrane http://togogenome.org/gene/9595:LOC101153072 ^@ http://purl.uniprot.org/uniprot/G3R2D5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9595:ACE2 ^@ http://purl.uniprot.org/uniprot/G3QWX4 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M2 family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Cytoplasm|||Membrane|||Secreted|||cilium http://togogenome.org/gene/9595:GIP ^@ http://purl.uniprot.org/uniprot/G3SCT1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.|||Secreted http://togogenome.org/gene/9595:AKAP3 ^@ http://purl.uniprot.org/uniprot/G3RED8 ^@ Similarity ^@ Belongs to the AKAP110 family. http://togogenome.org/gene/9595:NPNT ^@ http://purl.uniprot.org/uniprot/A0A2I2ZRN1|||http://purl.uniprot.org/uniprot/G3RCY8|||http://purl.uniprot.org/uniprot/G3S615 ^@ Caution|||Similarity ^@ Belongs to the nephronectin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:JAG1 ^@ http://purl.uniprot.org/uniprot/G3RXX3 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/9595:SLC24A3 ^@ http://purl.uniprot.org/uniprot/G3QP00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/9595:ADAM33 ^@ http://purl.uniprot.org/uniprot/G3RLB2|||http://purl.uniprot.org/uniprot/G3RSF1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:LOC109025909 ^@ http://purl.uniprot.org/uniprot/G3RQE7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space|||Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. http://togogenome.org/gene/9595:SLC25A22 ^@ http://purl.uniprot.org/uniprot/G3R5C9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9595:TATDN2 ^@ http://purl.uniprot.org/uniprot/G3R3S1 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. http://togogenome.org/gene/9595:GALP ^@ http://purl.uniprot.org/uniprot/G3RDW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the galanin family.|||Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion.|||Secreted http://togogenome.org/gene/9595:GNPDA2 ^@ http://purl.uniprot.org/uniprot/G3RIE4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/9595:C3 ^@ http://purl.uniprot.org/uniprot/G3SA61 ^@ Function|||Subcellular Location Annotation ^@ Acts as a chemoattractant for neutrophils in chronic inflammation.|||C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.|||Secreted http://togogenome.org/gene/9595:VNN2 ^@ http://purl.uniprot.org/uniprot/G3R492 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. http://togogenome.org/gene/9595:KIF14 ^@ http://purl.uniprot.org/uniprot/G3RD87 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9595:GLRA1 ^@ http://purl.uniprot.org/uniprot/G3REP2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane|||dendrite http://togogenome.org/gene/9595:UBAC2 ^@ http://purl.uniprot.org/uniprot/G3SKK0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:CDK1 ^@ http://purl.uniprot.org/uniprot/G3RBW7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:ZFYVE27 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZRA3|||http://purl.uniprot.org/uniprot/G3SEV8 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Endosome membrane|||Membrane|||Recycling endosome membrane|||growth cone membrane http://togogenome.org/gene/9595:FURIN ^@ http://purl.uniprot.org/uniprot/G3QYP4 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9595:IER5 ^@ http://purl.uniprot.org/uniprot/G3RAR3 ^@ Similarity ^@ Belongs to the IER family. http://togogenome.org/gene/9595:SLC16A12 ^@ http://purl.uniprot.org/uniprot/G3QN08 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:AMBN ^@ http://purl.uniprot.org/uniprot/G3RCU1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ameloblastin family.|||Involved in the mineralization and structural organization of enamel.|||extracellular matrix http://togogenome.org/gene/9595:PF4V1 ^@ http://purl.uniprot.org/uniprot/G3SA05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9595:SNAPIN ^@ http://purl.uniprot.org/uniprot/G3QHF8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAPIN family.|||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.|||synaptic vesicle membrane http://togogenome.org/gene/9595:GJD3 ^@ http://purl.uniprot.org/uniprot/G3QKT2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9595:BOLA1 ^@ http://purl.uniprot.org/uniprot/G3QKD2 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/9595:IL1R1 ^@ http://purl.uniprot.org/uniprot/G3QLD8 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9595:SETD7 ^@ http://purl.uniprot.org/uniprot/G3R7Y6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.|||Chromosome|||Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.|||Nucleus http://togogenome.org/gene/9595:EMP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZUU0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the PMP-22/EMP/MP20 family.|||Cell membrane|||Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion.|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Membrane raft|||Nucleus|||perinuclear region http://togogenome.org/gene/9595:TXNRD2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZNN4 ^@ Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. http://togogenome.org/gene/9595:TUSC3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y386|||http://purl.uniprot.org/uniprot/G3RER4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:THRA ^@ http://purl.uniprot.org/uniprot/G3R2I5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9595:DRC7 ^@ http://purl.uniprot.org/uniprot/G3QZG8|||http://purl.uniprot.org/uniprot/G3SHC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC7 family.|||cilium axoneme|||flagellum|||flagellum axoneme http://togogenome.org/gene/9595:HDDC2 ^@ http://purl.uniprot.org/uniprot/G3SI01 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HDDC2 family.|||Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).|||Homodimer. http://togogenome.org/gene/9595:LCE1B ^@ http://purl.uniprot.org/uniprot/G3S2H5 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9595:TPH2 ^@ http://purl.uniprot.org/uniprot/G3RB08 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/9595:LOC101133708 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZXD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:INPP4B ^@ http://purl.uniprot.org/uniprot/G3S6A4 ^@ Similarity ^@ Belongs to the inositol 3,4-bisphosphate 4-phosphatase family. http://togogenome.org/gene/9595:MRPL37 ^@ http://purl.uniprot.org/uniprot/G3R4P7 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9595:HAUS1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YSL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HAUS1 family.|||spindle http://togogenome.org/gene/9595:LAMP5 ^@ http://purl.uniprot.org/uniprot/G3RC35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9595:FAM166B ^@ http://purl.uniprot.org/uniprot/G3R0X9 ^@ Similarity ^@ Belongs to the CIMIP2 family. http://togogenome.org/gene/9595:DDX56 ^@ http://purl.uniprot.org/uniprot/G3R8N1 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9595:CEP44 ^@ http://purl.uniprot.org/uniprot/A0A2I2YC76|||http://purl.uniprot.org/uniprot/G3SDT4 ^@ Subcellular Location Annotation ^@ Midbody|||centriole|||spindle pole http://togogenome.org/gene/9595:SLC16A7 ^@ http://purl.uniprot.org/uniprot/G3SEK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/9595:PDZK1IP1 ^@ http://purl.uniprot.org/uniprot/G3R7X9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:SAA4 ^@ http://purl.uniprot.org/uniprot/G3RZ43 ^@ Function|||Similarity ^@ Belongs to the SAA family.|||Major acute phase reactant. Apolipoprotein of the HDL complex. http://togogenome.org/gene/9595:FHIP2A ^@ http://purl.uniprot.org/uniprot/A0A2I2Z5Z5|||http://purl.uniprot.org/uniprot/G3RZX4 ^@ Similarity ^@ Belongs to the FHIP family. http://togogenome.org/gene/9595:GJD4 ^@ http://purl.uniprot.org/uniprot/G3QST2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9595:DAPK3 ^@ http://purl.uniprot.org/uniprot/G3QHZ8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:EMC4 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZU21|||http://purl.uniprot.org/uniprot/G3R5R9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC4 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:NAGPA ^@ http://purl.uniprot.org/uniprot/G3QQ81 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:XAGE5 ^@ http://purl.uniprot.org/uniprot/G3QWF7 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9595:TFE3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YS93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/9595:NDP ^@ http://purl.uniprot.org/uniprot/G3RCG7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9595:PAGE1 ^@ http://purl.uniprot.org/uniprot/G3QY22 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9595:PHAX ^@ http://purl.uniprot.org/uniprot/G3RDD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PHAX family.|||Cytoplasm http://togogenome.org/gene/9595:TUBB1 ^@ http://purl.uniprot.org/uniprot/G3RKF0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9595:UGGT2 ^@ http://purl.uniprot.org/uniprot/G3R5H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 8 family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9595:ANXA13 ^@ http://purl.uniprot.org/uniprot/G3QYM5 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9595:S100A10 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZWR8 ^@ Function ^@ Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. http://togogenome.org/gene/9595:SNAPC3 ^@ http://purl.uniprot.org/uniprot/G3QV46 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNAPC3/SRD2 family.|||Nucleus|||Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.|||Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. http://togogenome.org/gene/9595:EIPR1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YRZ5|||http://purl.uniprot.org/uniprot/G3RBH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat EIPR1 family.|||trans-Golgi network http://togogenome.org/gene/9595:RETNLB ^@ http://purl.uniprot.org/uniprot/G3R311 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the resistin/FIZZ family.|||Secreted http://togogenome.org/gene/9595:GSTCD ^@ http://purl.uniprot.org/uniprot/A0A2I2ZUI1 ^@ Similarity ^@ Belongs to the GSTCD family. http://togogenome.org/gene/9595:MRM1 ^@ http://purl.uniprot.org/uniprot/G3SHA1 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. http://togogenome.org/gene/9595:ASTL ^@ http://purl.uniprot.org/uniprot/G3R9B1 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:CFAP157 ^@ http://purl.uniprot.org/uniprot/G3SG76 ^@ Similarity ^@ Belongs to the CFAP157 family. http://togogenome.org/gene/9595:DLX5 ^@ http://purl.uniprot.org/uniprot/G3QP29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus http://togogenome.org/gene/9595:TLE3 ^@ http://purl.uniprot.org/uniprot/G3SBS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat Groucho/TLE family.|||Nucleus http://togogenome.org/gene/9595:SLC5A12 ^@ http://purl.uniprot.org/uniprot/G3R1P9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:OIP5 ^@ http://purl.uniprot.org/uniprot/G3QDK2 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.|||centromere http://togogenome.org/gene/9595:KATNAL1 ^@ http://purl.uniprot.org/uniprot/G3S5S1 ^@ Activity Regulation|||Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.|||Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.|||Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.|||Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.|||Cytoplasm|||Interacts with KATNB1 and KATNBL1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Midbody|||Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.|||Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.|||The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.|||Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.|||centrosome|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/9595:KIF4A ^@ http://purl.uniprot.org/uniprot/G3S0T3 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9595:ERBB4 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z667|||http://purl.uniprot.org/uniprot/G3REI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/9595:CENPM ^@ http://purl.uniprot.org/uniprot/A0A2I2ZDJ6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:FAM13A ^@ http://purl.uniprot.org/uniprot/A0A2I2YCU7|||http://purl.uniprot.org/uniprot/A0A2I2Z1M0|||http://purl.uniprot.org/uniprot/A0A2I2ZIL9 ^@ Similarity ^@ Belongs to the FAM13 family. http://togogenome.org/gene/9595:SLC13A5 ^@ http://purl.uniprot.org/uniprot/G3QDD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/9595:NMNAT3 ^@ http://purl.uniprot.org/uniprot/G3RQH0 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/9595:MMD2 ^@ http://purl.uniprot.org/uniprot/G3SEX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9595:COG3 ^@ http://purl.uniprot.org/uniprot/G3QT79 ^@ Function|||Similarity ^@ Belongs to the COG3 family.|||Involved in ER-Golgi transport. http://togogenome.org/gene/9595:CNOT9 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y9V2|||http://purl.uniprot.org/uniprot/A0A2I2ZFB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT9 family.|||P-body http://togogenome.org/gene/9595:LOC101142657 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y5W8|||http://purl.uniprot.org/uniprot/G3S085 ^@ Similarity ^@ Belongs to the filamin family. http://togogenome.org/gene/9595:ACTN1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZUB0|||http://purl.uniprot.org/uniprot/G3RK88|||http://purl.uniprot.org/uniprot/G3S5U4 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/9595:SLC7A8 ^@ http://purl.uniprot.org/uniprot/G3QWU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:TULP3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YNT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TUB family.|||Secreted http://togogenome.org/gene/9595:TMEM231 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZLG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM231 family.|||Membrane|||Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.|||cilium membrane http://togogenome.org/gene/9595:TUBB ^@ http://purl.uniprot.org/uniprot/G3SB76 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9595:HMGA2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YMA3|||http://purl.uniprot.org/uniprot/A0A2I2ZE73|||http://purl.uniprot.org/uniprot/A0A2I2ZTF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGA family.|||Nucleus http://togogenome.org/gene/9595:USP2 ^@ http://purl.uniprot.org/uniprot/G3QQW0 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9595:CCT2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZL99|||http://purl.uniprot.org/uniprot/G3QTT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9595:ZHX1 ^@ http://purl.uniprot.org/uniprot/A1YF22 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a transcriptional repressor.|||Belongs to the ZHX family.|||Forms homodimers. Also forms heterodimers with ZHX3 which is a prerequisite for repressor activity and with ZHX2. Interacts with NFYA. Interacts with ATF7IP (By similarity).|||Nucleus http://togogenome.org/gene/9595:KCNK6 ^@ http://purl.uniprot.org/uniprot/G3R3G0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9595:CPO ^@ http://purl.uniprot.org/uniprot/G3RIY9 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9595:CSTPP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZBY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSTPP1 family.|||cytoskeleton http://togogenome.org/gene/9595:DLAT ^@ http://purl.uniprot.org/uniprot/G3QJ95 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Binds 2 lipoyl cofactors covalently.|||Mitochondrion matrix|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). http://togogenome.org/gene/9595:MPV17 ^@ http://purl.uniprot.org/uniprot/G3SDX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/9595:GATA3 ^@ http://purl.uniprot.org/uniprot/G3QTK0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:NKX2-2 ^@ http://purl.uniprot.org/uniprot/G3QYG3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:FABP3 ^@ http://purl.uniprot.org/uniprot/G3RET1 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9595:LIPE ^@ http://purl.uniprot.org/uniprot/G3RPT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 'GDXG' lipolytic enzyme family.|||Cell membrane|||Lipid droplet|||caveola|||cytosol http://togogenome.org/gene/9595:STPG4 ^@ http://purl.uniprot.org/uniprot/G3QJ99 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9595:SSTR3 ^@ http://purl.uniprot.org/uniprot/G3QFM1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:ANXA5 ^@ http://purl.uniprot.org/uniprot/G3RKK8 ^@ Domain|||Function|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. http://togogenome.org/gene/9595:PLA2G5 ^@ http://purl.uniprot.org/uniprot/G3QVJ8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9595:THBS2 ^@ http://purl.uniprot.org/uniprot/G3QK81 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:DDX31 ^@ http://purl.uniprot.org/uniprot/G3QZ32 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9595:CIAPIN1 ^@ http://purl.uniprot.org/uniprot/G3S917 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the anamorsin family.|||Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion intermembrane space|||Monomer. Interacts with NDOR1. Interacts with CHCHD4.|||Nucleus|||The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.|||The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.|||The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space. http://togogenome.org/gene/9595:DBX2 ^@ http://purl.uniprot.org/uniprot/G3QPS0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:PMF1 ^@ http://purl.uniprot.org/uniprot/G3R5R0|||http://purl.uniprot.org/uniprot/G3RSF3 ^@ Subcellular Location Annotation ^@ Nucleus|||kinetochore http://togogenome.org/gene/9595:KMT2A ^@ http://purl.uniprot.org/uniprot/G3S2F4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.|||Nucleus http://togogenome.org/gene/9595:GSG1 ^@ http://purl.uniprot.org/uniprot/G3QZQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSG1 family.|||Membrane http://togogenome.org/gene/9595:GNAO1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YU68|||http://purl.uniprot.org/uniprot/G3QIY9 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9595:LOC101150279 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZY13|||http://purl.uniprot.org/uniprot/G3SDI2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MHC class I family.|||Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).|||Involved in the presentation of foreign antigens to the immune system. http://togogenome.org/gene/9595:HOXC11 ^@ http://purl.uniprot.org/uniprot/G3SBM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9595:CDC123 ^@ http://purl.uniprot.org/uniprot/A0A2I2YZN4|||http://purl.uniprot.org/uniprot/G3RXA6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC123 family.|||Cytoplasm|||Required for S phase entry of the cell cycle. http://togogenome.org/gene/9595:HDAC1 ^@ http://purl.uniprot.org/uniprot/G3R7V7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins.|||Nucleus http://togogenome.org/gene/9595:DSC1 ^@ http://purl.uniprot.org/uniprot/G3RCH6 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.|||Membrane|||desmosome http://togogenome.org/gene/9595:MITF ^@ http://purl.uniprot.org/uniprot/G3S312 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/9595:NDUFA9 ^@ http://purl.uniprot.org/uniprot/Q0MQB3 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Acetylated on lysine residues. BLOC1S1 is required for acetylation.|||Belongs to the complex I NDUFA9 subunit family.|||Binds 1 FAD per subunit.|||Complex I is composed of 45 different subunits (By similarity). This a component of the hydrophobic protein fraction (By similarity). Interacts with BLOC1S1 (By similarity). Interacts with SLC2A4 (By similarity). Interacts with CLOCK (By similarity). Interacts with RAB5IF (By similarity).|||Mitochondrion matrix http://togogenome.org/gene/9595:LRRC8B ^@ http://purl.uniprot.org/uniprot/G3QTC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:CD68 ^@ http://purl.uniprot.org/uniprot/A0A2I2YG68 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9595:TENT5A ^@ http://purl.uniprot.org/uniprot/G3QFV6 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/9595:PCOLCE ^@ http://purl.uniprot.org/uniprot/G3R5A8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9595:LIPG ^@ http://purl.uniprot.org/uniprot/G3QE94 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9595:IMPDH1 ^@ http://purl.uniprot.org/uniprot/G3QMZ1|||http://purl.uniprot.org/uniprot/G3RZ87 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.|||Nucleus http://togogenome.org/gene/9595:PTOV1 ^@ http://purl.uniprot.org/uniprot/G3RM16 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activates transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation.|||Belongs to the Mediator complex subunit 25 family. PTOV1 subfamily.|||Cell membrane|||Cytoplasm|||May interact with CREBBP. Interacts with FLOT1.|||Nucleus|||perinuclear region http://togogenome.org/gene/9595:HERC4 ^@ http://purl.uniprot.org/uniprot/A0A2I2YMU2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:EBF2 ^@ http://purl.uniprot.org/uniprot/G3QGU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COE family.|||Nucleus http://togogenome.org/gene/9595:EBNA1BP2 ^@ http://purl.uniprot.org/uniprot/G3R052 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP2 family.|||Required for the processing of the 27S pre-rRNA.|||nucleolus http://togogenome.org/gene/9595:STX18 ^@ http://purl.uniprot.org/uniprot/G3R6A0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Endoplasmic reticulum membrane|||Membrane|||Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. http://togogenome.org/gene/9595:CXCR6 ^@ http://purl.uniprot.org/uniprot/G3QQ28 ^@ Function|||Similarity ^@ Belongs to the G-protein coupled receptor 1 family.|||Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1. http://togogenome.org/gene/9595:TMED1 ^@ http://purl.uniprot.org/uniprot/G3QT41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9595:SCPEP1 ^@ http://purl.uniprot.org/uniprot/G3RS33 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/9595:SLC6A19 ^@ http://purl.uniprot.org/uniprot/G3QX55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9595:CENPA ^@ http://purl.uniprot.org/uniprot/A0A2I2Y1U4|||http://purl.uniprot.org/uniprot/G3SF93 ^@ Similarity ^@ Belongs to the histone H3 family. http://togogenome.org/gene/9595:BCAP29 ^@ http://purl.uniprot.org/uniprot/G3SAF0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCAP29/BCAP31 family.|||Endoplasmic reticulum membrane|||Membrane|||Plays a role in the export of secreted proteins in the ER. http://togogenome.org/gene/9595:ZSCAN1 ^@ http://purl.uniprot.org/uniprot/G3RHN2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:LIN54 ^@ http://purl.uniprot.org/uniprot/A0A2I2YFY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-54 family.|||Nucleus http://togogenome.org/gene/9595:DDX50 ^@ http://purl.uniprot.org/uniprot/G3RT42 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily. http://togogenome.org/gene/9595:SERPINB6 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z2G9|||http://purl.uniprot.org/uniprot/G3R677 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9595:MAPKAPK3 ^@ http://purl.uniprot.org/uniprot/G3RG39 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:CNNM1 ^@ http://purl.uniprot.org/uniprot/G3QJB7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ACDP family.|||Cell membrane|||Membrane|||Metal transporter. http://togogenome.org/gene/9595:PLAC8L1 ^@ http://purl.uniprot.org/uniprot/G3QYX5 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/9595:DAD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YH80 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DAD/OST2 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/9595:PIWIL3 ^@ http://purl.uniprot.org/uniprot/G3RHJ8 ^@ Similarity ^@ Belongs to the argonaute family. http://togogenome.org/gene/9595:MEP1B ^@ http://purl.uniprot.org/uniprot/G3SF75 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:RNF13 ^@ http://purl.uniprot.org/uniprot/G3QW07 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:MED23 ^@ http://purl.uniprot.org/uniprot/G3QFA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 23 family.|||Nucleus http://togogenome.org/gene/9595:PKD2 ^@ http://purl.uniprot.org/uniprot/G3QLB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the polycystin family.|||Cell membrane|||Membrane|||cilium membrane http://togogenome.org/gene/9595:CDH20 ^@ http://purl.uniprot.org/uniprot/G3QVJ7 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:CCL14 ^@ http://purl.uniprot.org/uniprot/G3SA76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9595:SLC30A6 ^@ http://purl.uniprot.org/uniprot/A0A2I2YNK1|||http://purl.uniprot.org/uniprot/A0A2I2YR01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9595:CNKSR3 ^@ http://purl.uniprot.org/uniprot/G3QFX6 ^@ Similarity ^@ Belongs to the CNKSR family. http://togogenome.org/gene/9595:SEC22C ^@ http://purl.uniprot.org/uniprot/A0A2I2YM15|||http://purl.uniprot.org/uniprot/A0A2I2ZBL6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||May be involved in vesicle transport between the ER and the Golgi complex.|||Membrane http://togogenome.org/gene/9595:GPR15 ^@ http://purl.uniprot.org/uniprot/G3RCT5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:IFITM1 ^@ http://purl.uniprot.org/uniprot/G3QLG9 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9595:LDLRAD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z7G2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:PPME1 ^@ http://purl.uniprot.org/uniprot/G3QDL9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the AB hydrolase superfamily.|||Binds PPP2CA and PPP2CB.|||Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. http://togogenome.org/gene/9595:LOC109025290 ^@ http://purl.uniprot.org/uniprot/A0A2I2YPE0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/9595:SNRPA1 ^@ http://purl.uniprot.org/uniprot/G3RZB2 ^@ Similarity ^@ Belongs to the U2 small nuclear ribonucleoprotein A family. http://togogenome.org/gene/9595:EPHB6 ^@ http://purl.uniprot.org/uniprot/G3RHU7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:UNG ^@ http://purl.uniprot.org/uniprot/G3RY62 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.|||Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.|||Mitochondrion|||Monomer. Interacts with FAM72A.|||Nucleus http://togogenome.org/gene/9595:UBALD2 ^@ http://purl.uniprot.org/uniprot/G3R841 ^@ Similarity ^@ Belongs to the UBALD family. http://togogenome.org/gene/9595:SLC25A42 ^@ http://purl.uniprot.org/uniprot/G3QYJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9595:REEP6 ^@ http://purl.uniprot.org/uniprot/G3QWJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/9595:TRNT1 ^@ http://purl.uniprot.org/uniprot/G3RGZ9 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/9595:MRPS9 ^@ http://purl.uniprot.org/uniprot/G3QXN0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/9595:AQP9 ^@ http://purl.uniprot.org/uniprot/G3R8Y0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9595:NEURL2 ^@ http://purl.uniprot.org/uniprot/G3RIM8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:HMOX2 ^@ http://purl.uniprot.org/uniprot/G3QZI8 ^@ Similarity ^@ Belongs to the heme oxygenase family. http://togogenome.org/gene/9595:SFTPD ^@ http://purl.uniprot.org/uniprot/G3R0R1 ^@ Similarity|||Subunit ^@ Belongs to the SFTPD family.|||Oligomeric complex of 4 set of homotrimers. http://togogenome.org/gene/9595:SEC24C ^@ http://purl.uniprot.org/uniprot/G3QTL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9595:SKIC2 ^@ http://purl.uniprot.org/uniprot/G3QIM4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:LOC101133357 ^@ http://purl.uniprot.org/uniprot/G3QYX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:MYO1H ^@ http://purl.uniprot.org/uniprot/G3RXN4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9595:IL17RA ^@ http://purl.uniprot.org/uniprot/G3RZP6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:DPYSL5 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z098 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/9595:PRPS1 ^@ http://purl.uniprot.org/uniprot/G3R9N5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family.|||Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.|||Homodimer. The active form is probably a hexamer composed of 3 homodimers. http://togogenome.org/gene/9595:NUBP2 ^@ http://purl.uniprot.org/uniprot/G3QTT7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.|||Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.|||Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.|||Cytoplasm|||Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.|||Nucleus|||centrosome http://togogenome.org/gene/9595:SLC30A8 ^@ http://purl.uniprot.org/uniprot/G3RJB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9595:NKAIN1 ^@ http://purl.uniprot.org/uniprot/G3RV40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NKAIN family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:PDHX ^@ http://purl.uniprot.org/uniprot/A0A2I2Z7A6|||http://purl.uniprot.org/uniprot/G3QFV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Mitochondrion matrix http://togogenome.org/gene/9595:SGSM3 ^@ http://purl.uniprot.org/uniprot/G3RGQ0 ^@ Similarity ^@ Belongs to the small G protein signaling modulator family. http://togogenome.org/gene/9595:NDUFB9 ^@ http://purl.uniprot.org/uniprot/Q0MQE9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I LYR family.|||Mammalian complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:LOC101148834 ^@ http://purl.uniprot.org/uniprot/G3QEE4 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL11 family.|||Binds directly to 26S ribosomal RNA. http://togogenome.org/gene/9595:APH1A ^@ http://purl.uniprot.org/uniprot/G3RLP7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the APH-1 family.|||Component of the gamma-secretase complex.|||Membrane|||Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. http://togogenome.org/gene/9595:DUSP4 ^@ http://purl.uniprot.org/uniprot/G3QSY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/9595:MARF1 ^@ http://purl.uniprot.org/uniprot/G3R0R4 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/9595:GGH ^@ http://purl.uniprot.org/uniprot/G3QXM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C26 family.|||extracellular space http://togogenome.org/gene/9595:CPSF4L ^@ http://purl.uniprot.org/uniprot/G3SJG1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CPSF4/YTH1 family.|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex.|||Nucleus http://togogenome.org/gene/9595:IL12B ^@ http://purl.uniprot.org/uniprot/G3QP48 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.|||Belongs to the IL-12B family.|||Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.|||Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12.|||Secreted http://togogenome.org/gene/9595:ADAM9 ^@ http://purl.uniprot.org/uniprot/G3QTB8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:TMEM135 ^@ http://purl.uniprot.org/uniprot/A0A2I2YAS2|||http://purl.uniprot.org/uniprot/G3QJE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM135 family.|||Membrane http://togogenome.org/gene/9595:IGFBP5 ^@ http://purl.uniprot.org/uniprot/G3RZ84 ^@ Caution|||Function|||Subcellular Location Annotation ^@ IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9595:EIF3L ^@ http://purl.uniprot.org/uniprot/A0A2I2ZBL1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit L family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RRN3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm http://togogenome.org/gene/9595:LOC101136057 ^@ http://purl.uniprot.org/uniprot/G3S7Z1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:MYO1B ^@ http://purl.uniprot.org/uniprot/A0A2I2Y765|||http://purl.uniprot.org/uniprot/A0A2I2YRV5|||http://purl.uniprot.org/uniprot/G3QIS4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9595:RNF146 ^@ http://purl.uniprot.org/uniprot/G3R9N0 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Can form homooligomers. Interacts with PARsylated AXIN1, AXIN2, BLZF1, CASC3, H1-2, IPO7, LIG3, NCL, PARP1, XRCC1, XRCC5 and XRCC6. Interacts with DDB1, DHX15, IQGAP1, LRPPRC, PARP2, PRKDC, RUVBL2, TNKS1 and TNKS2. Binding often leads to interactor ubiquitination, in the presence of the appropriate E1 and E2 enzymes, and proteasomal degradation.|||E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.|||The WWE domain mediates non-covalent poly(ADP-ribose)-binding.|||Ubiquitinated; autoubiquitinated.|||cytosol http://togogenome.org/gene/9595:MOCOS ^@ http://purl.uniprot.org/uniprot/G3R2H1 ^@ Function|||Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.|||Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. http://togogenome.org/gene/9595:LEP ^@ http://purl.uniprot.org/uniprot/G3QF76 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the leptin family.|||Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways. May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells. Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 wich promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38. In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses. Increases CD4(+)CD25(-) T-cell proliferation and reduces autophagy during TCR (T-cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation.|||Secreted http://togogenome.org/gene/9595:HOXA5 ^@ http://purl.uniprot.org/uniprot/G3QIH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9595:TP53 ^@ http://purl.uniprot.org/uniprot/G3R2U9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.|||Belongs to the p53 family.|||Binds 1 zinc ion per subunit.|||Binds DNA as a homotetramer.|||Cytoplasm|||Endoplasmic reticulum|||Mitochondrion matrix|||Nucleus|||PML body|||centrosome http://togogenome.org/gene/9595:VCP ^@ http://purl.uniprot.org/uniprot/G3QL07 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9595:GPR137 ^@ http://purl.uniprot.org/uniprot/A0A2I2YZB0|||http://purl.uniprot.org/uniprot/G3R979 ^@ Subcellular Location Annotation ^@ Lysosome membrane|||Membrane http://togogenome.org/gene/9595:IFRD2 ^@ http://purl.uniprot.org/uniprot/G3QVY0 ^@ Similarity ^@ Belongs to the IFRD family. http://togogenome.org/gene/9595:MED13 ^@ http://purl.uniprot.org/uniprot/G3R2F1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 13 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9595:LOC101142869 ^@ http://purl.uniprot.org/uniprot/G3RQ76 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9595:CAP2 ^@ http://purl.uniprot.org/uniprot/G3RJN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAP family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:OTUB2 ^@ http://purl.uniprot.org/uniprot/G3QV24 ^@ Similarity ^@ Belongs to the peptidase C65 family. http://togogenome.org/gene/9595:RPS26 ^@ http://purl.uniprot.org/uniprot/G3R7E3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS26 family. http://togogenome.org/gene/9595:HTR1B ^@ http://purl.uniprot.org/uniprot/G3RV57 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.|||Homodimer. Heterodimer with HTR1D.|||Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.|||Membrane|||Palmitoylated.|||Phosphorylated. http://togogenome.org/gene/9595:KIZ ^@ http://purl.uniprot.org/uniprot/G3RNL7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the kizuna family.|||Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.|||centrosome|||cilium basal body http://togogenome.org/gene/9595:LOC101152321 ^@ http://purl.uniprot.org/uniprot/G3RXT8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9595:TNFRSF1A ^@ http://purl.uniprot.org/uniprot/G3SG18 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:BPNT2 ^@ http://purl.uniprot.org/uniprot/G3RPL5 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/9595:EWSR1 ^@ http://purl.uniprot.org/uniprot/G3R945|||http://purl.uniprot.org/uniprot/G3RNC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TET family.|||Nucleus http://togogenome.org/gene/9595:SMAD5 ^@ http://purl.uniprot.org/uniprot/G3RTX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:LOC101127179 ^@ http://purl.uniprot.org/uniprot/G3RPS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:MEF2C ^@ http://purl.uniprot.org/uniprot/G3QK42|||http://purl.uniprot.org/uniprot/G3RY38 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:C10H10orf53 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z7V0|||http://purl.uniprot.org/uniprot/G3RMH5 ^@ Similarity ^@ Belongs to the UPF0728 family. http://togogenome.org/gene/9595:FXYD2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZHY3|||http://purl.uniprot.org/uniprot/G3S4V1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FXYD family.|||May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.|||Membrane|||Regulatory subunit of the sodium/potassium-transporting ATPase which is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. http://togogenome.org/gene/9595:CTSZ ^@ http://purl.uniprot.org/uniprot/G3RKE4 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/9595:SORCS1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z2C3 ^@ Similarity ^@ Belongs to the VPS10-related sortilin family. SORCS subfamily. http://togogenome.org/gene/9595:ODC1 ^@ http://purl.uniprot.org/uniprot/G3QY86 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/9595:GOT1L1 ^@ http://purl.uniprot.org/uniprot/G3RE96 ^@ Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer. http://togogenome.org/gene/9595:ROM1 ^@ http://purl.uniprot.org/uniprot/G3RCM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRPH2/ROM1 family.|||Membrane http://togogenome.org/gene/9595:RRP36 ^@ http://purl.uniprot.org/uniprot/G3QWG7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with 90S and pre-40S pre-ribosomal particles.|||Belongs to the RRP36 family.|||Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.|||nucleolus http://togogenome.org/gene/9595:LOC101125648 ^@ http://purl.uniprot.org/uniprot/G3RVH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ASB17 ^@ http://purl.uniprot.org/uniprot/G3QL23 ^@ Function|||Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family.|||May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/9595:AMT ^@ http://purl.uniprot.org/uniprot/G3RNZ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvT family.|||Mitochondrion|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/9595:RAB19 ^@ http://purl.uniprot.org/uniprot/G3RYU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane http://togogenome.org/gene/9595:ATAD2B ^@ http://purl.uniprot.org/uniprot/G3QT86 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9595:PYM1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YZ99|||http://purl.uniprot.org/uniprot/A0A2I2ZTF3 ^@ Similarity|||Subunit ^@ Belongs to the pym family.|||Interacts (via N-terminus) with magoh and rbm8a; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex. http://togogenome.org/gene/9595:ATP5IF1 ^@ http://purl.uniprot.org/uniprot/G3QEV8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase inhibitor family.|||Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.|||Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.|||Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.|||Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.|||Mitochondrion http://togogenome.org/gene/9595:SPTLC3 ^@ http://purl.uniprot.org/uniprot/G3RA20 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9595:SLC2A3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZMF8 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Cell projection|||Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Perikaryon|||Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm. http://togogenome.org/gene/9595:ATPAF2 ^@ http://purl.uniprot.org/uniprot/G3QE00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP12 family.|||Mitochondrion http://togogenome.org/gene/9595:LSM14A ^@ http://purl.uniprot.org/uniprot/G3QHB1 ^@ Similarity ^@ Belongs to the LSM14 family. http://togogenome.org/gene/9595:IFI27L2 ^@ http://purl.uniprot.org/uniprot/G3QX46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFI6/IFI27 family.|||Membrane http://togogenome.org/gene/9595:JPT2 ^@ http://purl.uniprot.org/uniprot/G3QTN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:SERINC2 ^@ http://purl.uniprot.org/uniprot/G3QYU9|||http://purl.uniprot.org/uniprot/G3RMP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9595:GNMT ^@ http://purl.uniprot.org/uniprot/G3RCK3 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family. http://togogenome.org/gene/9595:LOC101144243 ^@ http://purl.uniprot.org/uniprot/G3RD37 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 6c family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:TRAM1L1 ^@ http://purl.uniprot.org/uniprot/G3QD22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAM family.|||Membrane http://togogenome.org/gene/9595:KCNG4 ^@ http://purl.uniprot.org/uniprot/G3QGS1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:PALS2 ^@ http://purl.uniprot.org/uniprot/G3QR22 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/9595:PF4 ^@ http://purl.uniprot.org/uniprot/G3RHN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9595:HCN1 ^@ http://purl.uniprot.org/uniprot/G3QGQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel HCN family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:SURF4 ^@ http://purl.uniprot.org/uniprot/G3SD28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SURF4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:TAS2R38 ^@ http://purl.uniprot.org/uniprot/A0A2K5TIZ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane|||Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. http://togogenome.org/gene/9595:SPG7 ^@ http://purl.uniprot.org/uniprot/G3RVG4 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/9595:KRT8 ^@ http://purl.uniprot.org/uniprot/G3SEY3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:H1-2 ^@ http://purl.uniprot.org/uniprot/G3QXG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9595:VAMP4 ^@ http://purl.uniprot.org/uniprot/G3SIP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9595:SNX32 ^@ http://purl.uniprot.org/uniprot/G3R5F7 ^@ Function|||Similarity ^@ Belongs to the sorting nexin family.|||Involved in several stages of intracellular trafficking. http://togogenome.org/gene/9595:GMPR ^@ http://purl.uniprot.org/uniprot/G3QNH0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.|||Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.|||Homotetramer. http://togogenome.org/gene/9595:FAM133B ^@ http://purl.uniprot.org/uniprot/A0A2I2ZXK8 ^@ Similarity ^@ Belongs to the FAM133 family. http://togogenome.org/gene/9595:ARHGEF7 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZG12 ^@ Subcellular Location Annotation ^@ lamellipodium http://togogenome.org/gene/9595:KCNC2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z6X8|||http://purl.uniprot.org/uniprot/G3S3N7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:ABCG4 ^@ http://purl.uniprot.org/uniprot/G3R9V2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/9595:LCA5L ^@ http://purl.uniprot.org/uniprot/G3RBH0 ^@ Similarity ^@ Belongs to the LCA5 family. http://togogenome.org/gene/9595:SDAD1 ^@ http://purl.uniprot.org/uniprot/G3QUA4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SDA1 family.|||Required for 60S pre-ribosomal subunits export to the cytoplasm.|||nucleolus http://togogenome.org/gene/9595:FAT4 ^@ http://purl.uniprot.org/uniprot/A0A2I2YI73 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:SLC26A7 ^@ http://purl.uniprot.org/uniprot/G3SD21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/9595:GALR1 ^@ http://purl.uniprot.org/uniprot/G3QG75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9595:MSR1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YAH6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:DUSP13B ^@ http://purl.uniprot.org/uniprot/A0A2I2ZMC6|||http://purl.uniprot.org/uniprot/G3R607 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/9595:PYCR2 ^@ http://purl.uniprot.org/uniprot/G3R1T4 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/9595:PDCD5 ^@ http://purl.uniprot.org/uniprot/A0A2I2YIR7|||http://purl.uniprot.org/uniprot/G3QTK5 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/9595:FAM228A ^@ http://purl.uniprot.org/uniprot/A0A2I2ZA00 ^@ Similarity ^@ Belongs to the FAM228 family. http://togogenome.org/gene/9595:SENP7 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZMJ6|||http://purl.uniprot.org/uniprot/G3R3D9 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/9595:SLC16A2 ^@ http://purl.uniprot.org/uniprot/G3R214 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:ZIC3 ^@ http://purl.uniprot.org/uniprot/G3R8B2|||http://purl.uniprot.org/uniprot/G3RYT4 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/9595:UBP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z5G6|||http://purl.uniprot.org/uniprot/G3SED0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus http://togogenome.org/gene/9595:KPNA5 ^@ http://purl.uniprot.org/uniprot/G3R8B6 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9595:XRN2 ^@ http://purl.uniprot.org/uniprot/G3SD30 ^@ Function|||Similarity ^@ Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.|||Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. http://togogenome.org/gene/9595:OPHN1 ^@ http://purl.uniprot.org/uniprot/G3SKP4 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Postsynapse|||Presynapse|||dendrite http://togogenome.org/gene/9595:LTB4R2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YAB5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:TPM3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZRG1|||http://purl.uniprot.org/uniprot/G3QDY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9595:FAXC ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1P2 ^@ Similarity ^@ Belongs to the FAX family. http://togogenome.org/gene/9595:IL19 ^@ http://purl.uniprot.org/uniprot/G3S310 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/9595:STK11IP ^@ http://purl.uniprot.org/uniprot/G3QRY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STK11IP family.|||Cytoplasm http://togogenome.org/gene/9595:RBP7 ^@ http://purl.uniprot.org/uniprot/G3RS30 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9595:AMH ^@ http://purl.uniprot.org/uniprot/G3S0U3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Plays an important role in several reproductive functions. Induces Muellerian duct regression during male fetal sexual differentiation and plays a role in Leydig cell differentiation and function. In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. AMH signals by binding to a specific type-II receptor, AMHR2, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A), and recruiting SMAD proteins that are translocated to the nucleus to regulate target gene expression.|||Secreted http://togogenome.org/gene/9595:SLC39A4 ^@ http://purl.uniprot.org/uniprot/G3RJC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Membrane http://togogenome.org/gene/9595:NR1H2 ^@ http://purl.uniprot.org/uniprot/G3QS62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9595:IFNK ^@ http://purl.uniprot.org/uniprot/G3S4T3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9595:GUCY1A1 ^@ http://purl.uniprot.org/uniprot/G3R8H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Cytoplasm http://togogenome.org/gene/9595:PPP2CB ^@ http://purl.uniprot.org/uniprot/G3RDM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/9595:PPP6R3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YMJ3|||http://purl.uniprot.org/uniprot/G3QUR8|||http://purl.uniprot.org/uniprot/G3S525 ^@ Similarity ^@ Belongs to the SAPS family. http://togogenome.org/gene/9595:YKT6 ^@ http://purl.uniprot.org/uniprot/G3RTQ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane|||Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity. http://togogenome.org/gene/9595:ANKRD13C ^@ http://purl.uniprot.org/uniprot/G3S318 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:MRPL42 ^@ http://purl.uniprot.org/uniprot/G3RSP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL42 family.|||Mitochondrion http://togogenome.org/gene/9595:SPOCK1 ^@ http://purl.uniprot.org/uniprot/G3QEU5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:IFT46 ^@ http://purl.uniprot.org/uniprot/G3S8A9|||http://purl.uniprot.org/uniprot/G3S8P3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFT46 family.|||cilium|||cilium basal body http://togogenome.org/gene/9595:LOC101140206 ^@ http://purl.uniprot.org/uniprot/G3S1W4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:KRT1 ^@ http://purl.uniprot.org/uniprot/G3QLP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intermediate filament family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9595:MPP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z2Z7 ^@ Function|||Subcellular Location Annotation ^@ Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity.|||stereocilium http://togogenome.org/gene/9595:ATP5PD ^@ http://purl.uniprot.org/uniprot/G3RCY6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase d subunit family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:RIGI ^@ http://purl.uniprot.org/uniprot/G3S7V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/9595:HFE ^@ http://purl.uniprot.org/uniprot/G3QU39 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MHC class I family.|||Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).|||Involved in the presentation of foreign antigens to the immune system. http://togogenome.org/gene/9595:DKK2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZPL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/9595:FOXI2 ^@ http://purl.uniprot.org/uniprot/G3QV33 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:KIF1B ^@ http://purl.uniprot.org/uniprot/G3SEL4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9595:CPT2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YJ86 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/9595:IFT20 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y652|||http://purl.uniprot.org/uniprot/A0A2I2ZW01 ^@ Subcellular Location Annotation ^@ centriole|||cilium|||cis-Golgi network http://togogenome.org/gene/9595:MLEC ^@ http://purl.uniprot.org/uniprot/A0A2I2ZR40|||http://purl.uniprot.org/uniprot/G3QWB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the malectin family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:LOC101147448 ^@ http://purl.uniprot.org/uniprot/A0A2I2YH02 ^@ Similarity ^@ Belongs to the UQCC4 family. http://togogenome.org/gene/9595:RPS8 ^@ http://purl.uniprot.org/uniprot/G3QS94 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS8 family. http://togogenome.org/gene/9595:LOC101137142 ^@ http://purl.uniprot.org/uniprot/G3QR80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:SLC2A4 ^@ http://purl.uniprot.org/uniprot/G3QWS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Endomembrane system|||Membrane|||perinuclear region http://togogenome.org/gene/9595:YPEL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y307 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9595:RCE1 ^@ http://purl.uniprot.org/uniprot/G3REW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase U48 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:ABCA1 ^@ http://purl.uniprot.org/uniprot/G3R1Y5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:LOC101125304 ^@ http://purl.uniprot.org/uniprot/G3RQI3 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9595:WNT6 ^@ http://purl.uniprot.org/uniprot/G3QL59 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9595:SMG6 ^@ http://purl.uniprot.org/uniprot/G3RWH9 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini.|||Plays a role in nonsense-mediated mRNA decay.|||The PINc domain confers endonuclease activity and is expected to bind the catalytic metal ion.|||cytosol|||nucleolus|||telomere http://togogenome.org/gene/9595:OLA1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YI01 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.|||Cytoplasm|||Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.|||Monomer.|||Nucleus|||nucleolus http://togogenome.org/gene/9595:ENPP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YZY5|||http://purl.uniprot.org/uniprot/G3QK63|||http://purl.uniprot.org/uniprot/G3RNC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.|||Secreted http://togogenome.org/gene/9595:CIAO2A ^@ http://purl.uniprot.org/uniprot/A0A2I2YYL6|||http://purl.uniprot.org/uniprot/G3RK86 ^@ Similarity ^@ Belongs to the MIP18 family. http://togogenome.org/gene/9595:PLIN2 ^@ http://purl.uniprot.org/uniprot/G3RK26 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/9595:GRPEL2 ^@ http://purl.uniprot.org/uniprot/G3QRN6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GrpE family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion matrix http://togogenome.org/gene/9595:HRK ^@ http://purl.uniprot.org/uniprot/G3QTJ6 ^@ Function|||Subcellular Location Annotation ^@ Mitochondrion|||Promotes apoptosis. http://togogenome.org/gene/9595:PTPRE ^@ http://purl.uniprot.org/uniprot/A0A2I2Z3D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:RPL22L1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZLJ2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL22 family. http://togogenome.org/gene/9595:LANCL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z0V7 ^@ Similarity ^@ Belongs to the LanC-like protein family. http://togogenome.org/gene/9595:GFRA2 ^@ http://purl.uniprot.org/uniprot/G3RD05 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GDNFR family.|||Cell membrane|||Membrane|||Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. http://togogenome.org/gene/9595:SEPTIN10 ^@ http://purl.uniprot.org/uniprot/A0A2I2YIZ9|||http://purl.uniprot.org/uniprot/A0A2I2ZL83 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9595:ERLEC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YL59|||http://purl.uniprot.org/uniprot/G3QE52 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OS-9 family.|||Endoplasmic reticulum lumen|||Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation. http://togogenome.org/gene/9595:GYS1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZL86 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase 3 family.|||Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. http://togogenome.org/gene/9595:RBBP4 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZFC8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SLC22A12 ^@ http://purl.uniprot.org/uniprot/A0A2I2YYG0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:AGMAT ^@ http://purl.uniprot.org/uniprot/G3RGP9 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/9595:LOC101144859 ^@ http://purl.uniprot.org/uniprot/G3QXY3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:OAS3 ^@ http://purl.uniprot.org/uniprot/G3QYL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-5A synthase family.|||Cytoplasm http://togogenome.org/gene/9595:SLC13A1 ^@ http://purl.uniprot.org/uniprot/G3QU34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/9595:TMEM129 ^@ http://purl.uniprot.org/uniprot/A0A2I2YUT9|||http://purl.uniprot.org/uniprot/A0A2I2Z010 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM129 family.|||Membrane http://togogenome.org/gene/9595:LOXL4 ^@ http://purl.uniprot.org/uniprot/G3QQ45 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/9595:IFNG ^@ http://purl.uniprot.org/uniprot/G3QT96 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II (or gamma) interferon family.|||Homodimer.|||Secreted|||Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL. Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation. http://togogenome.org/gene/9595:MED30 ^@ http://purl.uniprot.org/uniprot/G3R195 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 30 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/9595:OSBPL7 ^@ http://purl.uniprot.org/uniprot/G3RH58 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9595:ANP32A ^@ http://purl.uniprot.org/uniprot/G3RHC4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANP32 family.|||Multifunctional protein that is involved in the regulation of many processes.|||Nucleus http://togogenome.org/gene/9595:SNAP25 ^@ http://purl.uniprot.org/uniprot/A0A2I2YCP6|||http://purl.uniprot.org/uniprot/G3R985 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNAP-25 family.|||Cell membrane|||Membrane|||Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.|||Photoreceptor inner segment|||synaptosome|||t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. http://togogenome.org/gene/9595:SLC2A1 ^@ http://purl.uniprot.org/uniprot/G3RZS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Cell membrane|||Membrane|||Photoreceptor inner segment http://togogenome.org/gene/9595:PAGE4 ^@ http://purl.uniprot.org/uniprot/G3QDC4 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9595:NOB1 ^@ http://purl.uniprot.org/uniprot/G3SFM7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOB1 family.|||May play a role in mRNA degradation.|||Nucleus http://togogenome.org/gene/9595:FGFR1OP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YCV1|||http://purl.uniprot.org/uniprot/G3SEJ1 ^@ Similarity ^@ Belongs to the SIKE family. http://togogenome.org/gene/9595:CDC5L ^@ http://purl.uniprot.org/uniprot/A0A2I2YQW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEF1 family.|||Nucleus http://togogenome.org/gene/9595:LOC101144003 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZTU6 ^@ Similarity ^@ Belongs to the PRAME family. http://togogenome.org/gene/9595:TRMT2B ^@ http://purl.uniprot.org/uniprot/G3SG06 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:POLR3G ^@ http://purl.uniprot.org/uniprot/A0A2I2ZHI2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPC7 RNA polymerase subunit family.|||Component of the RNA polymerase III (Pol III) complex.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/9595:ATF7IP ^@ http://purl.uniprot.org/uniprot/G3SB83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCAF family.|||Nucleus http://togogenome.org/gene/9595:MYBL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZYZ0|||http://purl.uniprot.org/uniprot/G3SHW4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:LSM6 ^@ http://purl.uniprot.org/uniprot/G3QG40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/9595:INPP1 ^@ http://purl.uniprot.org/uniprot/G3S588 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/9595:LOC101137046 ^@ http://purl.uniprot.org/uniprot/G3QUU9 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9595:PYCR3 ^@ http://purl.uniprot.org/uniprot/G3QIY3 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/9595:BLMH ^@ http://purl.uniprot.org/uniprot/G3QRX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Cytoplasm http://togogenome.org/gene/9595:PLOD2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YIY7|||http://purl.uniprot.org/uniprot/G3REF3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9595:RPL6 ^@ http://purl.uniprot.org/uniprot/G3QLG0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL6 family. http://togogenome.org/gene/9595:NGF ^@ http://purl.uniprot.org/uniprot/Q9N2F0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NGF-beta family.|||Endosome lumen|||Homodimer. The homodimer interacts with a single NTRK1 chain. The homodimer interacts with a single NGFR chain (By similarity). The NGF dimer interacts with a single SORCS2 chain (via extracellular domain). The NGF precursor (proNGF) binds to a receptor complex formed by SORT1 and NGFR, which leads to NGF endocytosis. Both mature NGF and the immature NGF precursor (proNGF) interact with SORCS2 and with the heterodimer formed by SORCS2 and NGFR (via extracellular domains). The NGF precursor (proNGF) has much higher affinity for SORCS2 than mature NGF. The NGF precursor (proNGF) has much higher affinity for SORT1 than mature NGF (By similarity). Interacts with ADAM10 in a divalent cation-dependent manner (By similarity).|||Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (By similarity). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity).|||Secreted http://togogenome.org/gene/9595:MDM1 ^@ http://purl.uniprot.org/uniprot/G3QKW2|||http://purl.uniprot.org/uniprot/G3RPR2|||http://purl.uniprot.org/uniprot/G3S171 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM1 family.|||Nucleus|||centriole http://togogenome.org/gene/9595:BPNT1 ^@ http://purl.uniprot.org/uniprot/G3S9T6 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/9595:GPD1 ^@ http://purl.uniprot.org/uniprot/G3R865 ^@ Similarity ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/9595:FOXO3 ^@ http://purl.uniprot.org/uniprot/G3QLU0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:MAP2K5 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZBX6|||http://purl.uniprot.org/uniprot/A0A2I2ZQT1|||http://purl.uniprot.org/uniprot/G3QPY6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:SLC35E3 ^@ http://purl.uniprot.org/uniprot/G3SF52 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:TSPYL6 ^@ http://purl.uniprot.org/uniprot/G3QKY2 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9595:MVK ^@ http://purl.uniprot.org/uniprot/A0A2I2ZUP0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Mevalonate kinase subfamily.|||Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.|||Cytoplasm http://togogenome.org/gene/9595:SLC52A1 ^@ http://purl.uniprot.org/uniprot/G3RHZ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the riboflavin transporter family.|||Cell membrane|||Membrane|||Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. http://togogenome.org/gene/9595:INPP5J ^@ http://purl.uniprot.org/uniprot/A0A2I2ZYR0|||http://purl.uniprot.org/uniprot/G3QJK7 ^@ Similarity ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family. http://togogenome.org/gene/9595:CRP ^@ http://purl.uniprot.org/uniprot/G3S3N2 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pentraxin family.|||Binds 2 calcium ions per subunit.|||Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9595:SNX14 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y490|||http://purl.uniprot.org/uniprot/A0A2I2Y7X7|||http://purl.uniprot.org/uniprot/A0A2I2ZJ29 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9595:PRRT2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YQ23|||http://purl.uniprot.org/uniprot/A0A2I2ZU66 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9595:ADCK1 ^@ http://purl.uniprot.org/uniprot/G3R379 ^@ Similarity ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family. http://togogenome.org/gene/9595:SERPINB8 ^@ http://purl.uniprot.org/uniprot/G3R7L5 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9595:HSPA4L ^@ http://purl.uniprot.org/uniprot/G3RSH5 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9595:QPCT ^@ http://purl.uniprot.org/uniprot/G3QZV3 ^@ Similarity ^@ Belongs to the glutaminyl-peptide cyclotransferase family. http://togogenome.org/gene/9595:PLA2G2A ^@ http://purl.uniprot.org/uniprot/G3QZ00 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9595:LIPN ^@ http://purl.uniprot.org/uniprot/G3QL72 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9595:CKS2 ^@ http://purl.uniprot.org/uniprot/G3S076 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.|||Forms a homohexamer that can probably bind six kinase subunits. http://togogenome.org/gene/9595:NPY1R ^@ http://purl.uniprot.org/uniprot/G3QP89 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:EGR1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y6K9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Nucleus|||Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. http://togogenome.org/gene/9595:SDC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YZE2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane http://togogenome.org/gene/9595:RBBP5 ^@ http://purl.uniprot.org/uniprot/G3RFR6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:UCHL1 ^@ http://purl.uniprot.org/uniprot/G3R0C8 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/9595:KIF19 ^@ http://purl.uniprot.org/uniprot/G3RLI9 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9595:GDPD5 ^@ http://purl.uniprot.org/uniprot/G3RIG1 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9595:TMSB15A ^@ http://purl.uniprot.org/uniprot/G3RRF8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/9595:ZDHHC19 ^@ http://purl.uniprot.org/uniprot/G3S9C6 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9595:THADA ^@ http://purl.uniprot.org/uniprot/G3QXY5 ^@ Function|||Similarity ^@ Belongs to the THADA family.|||Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 32 of the anticodon loop of substrate tRNAs. http://togogenome.org/gene/9595:SPA17 ^@ http://purl.uniprot.org/uniprot/G3QMF2 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates. http://togogenome.org/gene/9595:MSX2 ^@ http://purl.uniprot.org/uniprot/A1YF16 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity).|||Belongs to the Msh homeobox family.|||Interacts with MINT, with XRCC6 (Ku70) and XRCC5 (Ku80).|||Nucleus http://togogenome.org/gene/9595:FECH ^@ http://purl.uniprot.org/uniprot/G3S2X4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferrochelatase family.|||Catalyzes the ferrous insertion into protoporphyrin IX.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:RPL14 ^@ http://purl.uniprot.org/uniprot/G3S186 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL14 family. http://togogenome.org/gene/9595:POLR3GL ^@ http://purl.uniprot.org/uniprot/G3R856|||http://purl.uniprot.org/uniprot/G3SHQ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPC7 RNA polymerase subunit family.|||Component of the RNA polymerase III (Pol III) complex.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/9595:VNN3P ^@ http://purl.uniprot.org/uniprot/G3RP52 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. http://togogenome.org/gene/9595:NLRP14 ^@ http://purl.uniprot.org/uniprot/G3QDW2 ^@ Similarity ^@ Belongs to the NLRP family. http://togogenome.org/gene/9595:SPRTN ^@ http://purl.uniprot.org/uniprot/G3QKV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Spartan family.|||Chromosome|||Nucleus http://togogenome.org/gene/9595:TOE1 ^@ http://purl.uniprot.org/uniprot/G3QL86 ^@ Similarity ^@ Belongs to the CAF1 family. http://togogenome.org/gene/9595:CHRM2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YUP6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. http://togogenome.org/gene/9595:MAP4 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZBP4|||http://purl.uniprot.org/uniprot/G3QNV8 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9595:PUS3 ^@ http://purl.uniprot.org/uniprot/G3RGD8 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/9595:FANCC ^@ http://purl.uniprot.org/uniprot/G3QT46|||http://purl.uniprot.org/uniprot/G3SD62 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. This complex may also include HSP70.|||DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.|||Nucleus http://togogenome.org/gene/9595:HTRA4 ^@ http://purl.uniprot.org/uniprot/G3QTA2 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/9595:FSHR ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1U6|||http://purl.uniprot.org/uniprot/G3RET5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.|||Membrane http://togogenome.org/gene/9595:ACTL7B ^@ http://purl.uniprot.org/uniprot/G3QYY8 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9595:COL4A1 ^@ http://purl.uniprot.org/uniprot/G3RA04 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.|||basement membrane http://togogenome.org/gene/9595:TMEM70 ^@ http://purl.uniprot.org/uniprot/G3RH79 ^@ Similarity ^@ Belongs to the TMEM70 family. http://togogenome.org/gene/9595:RPLP1 ^@ http://purl.uniprot.org/uniprot/G3S7X2 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/9595:DTWD2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YXC7|||http://purl.uniprot.org/uniprot/G3R2C7 ^@ Similarity ^@ Belongs to the TDD superfamily. DTWD2 family. http://togogenome.org/gene/9595:ORC2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZLE8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC2 family.|||Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.|||Component of the origin recognition complex (ORC).|||Nucleus http://togogenome.org/gene/9595:TMBIM6 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z4W6|||http://purl.uniprot.org/uniprot/G3S7K5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9595:DYNLT5 ^@ http://purl.uniprot.org/uniprot/G3QIZ5 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/9595:KRT18 ^@ http://purl.uniprot.org/uniprot/G3R3T2 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:TAF6 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y884|||http://purl.uniprot.org/uniprot/G3QJV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF6 family.|||Nucleus http://togogenome.org/gene/9595:TSPAN31 ^@ http://purl.uniprot.org/uniprot/G3SDI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9595:KDM4A ^@ http://purl.uniprot.org/uniprot/G3RYZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JHDM3 histone demethylase family.|||Nucleus http://togogenome.org/gene/9595:LOC101147326 ^@ http://purl.uniprot.org/uniprot/G3RL21 ^@ Similarity ^@ Belongs to the TACO1 family. http://togogenome.org/gene/9595:KDELR1 ^@ http://purl.uniprot.org/uniprot/G3RXH7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:NDST2 ^@ http://purl.uniprot.org/uniprot/G3QTP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/9595:PKN2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z7U9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cleavage furrow|||Midbody|||Nucleus http://togogenome.org/gene/9595:EPHB3 ^@ http://purl.uniprot.org/uniprot/G3RJK3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:LOC101128585 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZHY0|||http://purl.uniprot.org/uniprot/A0A2I2ZQG9|||http://purl.uniprot.org/uniprot/A0A2I2ZXP0|||http://purl.uniprot.org/uniprot/G3RPF6|||http://purl.uniprot.org/uniprot/G3S8W3|||http://purl.uniprot.org/uniprot/G3SB82|||http://purl.uniprot.org/uniprot/G3SDQ1 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. http://togogenome.org/gene/9595:GPX8 ^@ http://purl.uniprot.org/uniprot/G3RA98 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/9595:LPCAT2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YGK6 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9595:SLC6A14 ^@ http://purl.uniprot.org/uniprot/G3R5I3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9595:NGLY1 ^@ http://purl.uniprot.org/uniprot/G3QJW4|||http://purl.uniprot.org/uniprot/G3RSV6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transglutaminase-like superfamily. PNGase family.|||Cytoplasm|||Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins. http://togogenome.org/gene/9595:IRF2BP1 ^@ http://purl.uniprot.org/uniprot/G3SFM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF2BP family.|||Nucleus http://togogenome.org/gene/9595:CDH5 ^@ http://purl.uniprot.org/uniprot/G3SFI0 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:GKAP1 ^@ http://purl.uniprot.org/uniprot/G3QS27|||http://purl.uniprot.org/uniprot/G3RXC6 ^@ Similarity ^@ Belongs to the GKAP1 family. http://togogenome.org/gene/9595:AREG ^@ http://purl.uniprot.org/uniprot/G3R4Q9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:ANXA7 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZQ69|||http://purl.uniprot.org/uniprot/G3QP82 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9595:TRPC6 ^@ http://purl.uniprot.org/uniprot/G3R1D4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:EXOC3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YGD1 ^@ Similarity ^@ Belongs to the SEC6 family. http://togogenome.org/gene/9595:GDPD3 ^@ http://purl.uniprot.org/uniprot/G3R0Q2 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9595:SND1 ^@ http://purl.uniprot.org/uniprot/G3R2E7 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. http://togogenome.org/gene/9595:ZFYVE16 ^@ http://purl.uniprot.org/uniprot/G3S6W8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Early endosome membrane http://togogenome.org/gene/9595:ASB7 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZMY0 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9595:FAM3C ^@ http://purl.uniprot.org/uniprot/G3RJZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/9595:VGLL2 ^@ http://purl.uniprot.org/uniprot/G3RDT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vestigial family.|||Nucleus http://togogenome.org/gene/9595:LOC101141689 ^@ http://purl.uniprot.org/uniprot/G3QK27 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:PTPN11 ^@ http://purl.uniprot.org/uniprot/G3SJL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.|||Cytoplasm http://togogenome.org/gene/9595:SLC24A2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z4V7|||http://purl.uniprot.org/uniprot/G3RK82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/9595:ZDHHC1 ^@ http://purl.uniprot.org/uniprot/G3S107 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9595:TMOD3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YS59 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9595:POLD3 ^@ http://purl.uniprot.org/uniprot/G3RAT6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:CRIPT ^@ http://purl.uniprot.org/uniprot/G3RGF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRIPT family.|||Cytoplasm http://togogenome.org/gene/9595:APOD ^@ http://purl.uniprot.org/uniprot/G3QHM6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family.|||Homodimer.|||Secreted http://togogenome.org/gene/9595:ADCYAP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZFM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/9595:FAM135B ^@ http://purl.uniprot.org/uniprot/G3QWR5 ^@ Similarity ^@ Belongs to the FAM135 family. http://togogenome.org/gene/9595:B4GALT4 ^@ http://purl.uniprot.org/uniprot/G3R771 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9595:NBR1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YAA1 ^@ Subcellular Location Annotation ^@ Lysosome|||autophagosome http://togogenome.org/gene/9595:LOC101153230 ^@ http://purl.uniprot.org/uniprot/G3QL22 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9595:CNKSR1 ^@ http://purl.uniprot.org/uniprot/G3SD79 ^@ Similarity ^@ Belongs to the CNKSR family. http://togogenome.org/gene/9595:INTU ^@ http://purl.uniprot.org/uniprot/G3QKE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inturned family.|||Cell surface|||cilium basal body http://togogenome.org/gene/9595:RIPK2 ^@ http://purl.uniprot.org/uniprot/G3R5J2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.|||Cytoplasm|||Found in a signaling complex consisting of at least ARHGEF2, NOD2 and RIPK2.|||Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses. Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments. http://togogenome.org/gene/9595:RPN2 ^@ http://purl.uniprot.org/uniprot/G3SJW0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SWP1 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/9595:CUL5 ^@ http://purl.uniprot.org/uniprot/G3SHP7 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9595:EDA ^@ http://purl.uniprot.org/uniprot/G3QSY7 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9595:NIPBL ^@ http://purl.uniprot.org/uniprot/G3SDF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCC2/Nipped-B family.|||Nucleus http://togogenome.org/gene/9595:TLL1 ^@ http://purl.uniprot.org/uniprot/G3QD43 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:LOC101139122 ^@ http://purl.uniprot.org/uniprot/G3RRH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:LOC101145787 ^@ http://purl.uniprot.org/uniprot/G3QEE1|||http://purl.uniprot.org/uniprot/G3RZY8 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M2 family.|||Binds 1 zinc ion per subunit.|||Binds 2 Zn(2+) ions per subunit. http://togogenome.org/gene/9595:IRF8 ^@ http://purl.uniprot.org/uniprot/G3S6K3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:USP15 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y6G1|||http://purl.uniprot.org/uniprot/A0A2I2ZAZ8|||http://purl.uniprot.org/uniprot/G3QJX5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Cytoplasm|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Nucleus http://togogenome.org/gene/9595:BZW2 ^@ http://purl.uniprot.org/uniprot/G3RS12 ^@ Similarity ^@ Belongs to the BZW family. http://togogenome.org/gene/9595:MTHFD1 ^@ http://purl.uniprot.org/uniprot/G3QRA5 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.|||In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. http://togogenome.org/gene/9595:ZSCAN2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZCF1|||http://purl.uniprot.org/uniprot/G3RF88 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:GRM2 ^@ http://purl.uniprot.org/uniprot/G3R3I8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:OPN1SW ^@ http://purl.uniprot.org/uniprot/G3QSQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane|||Photoreceptor inner segment|||perinuclear region|||photoreceptor outer segment http://togogenome.org/gene/9595:LOC101135660 ^@ http://purl.uniprot.org/uniprot/G3QJI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:MARK1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1R1|||http://purl.uniprot.org/uniprot/G3QF81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||dendrite http://togogenome.org/gene/9595:MCIDAS ^@ http://purl.uniprot.org/uniprot/G3S280 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the geminin family.|||Nucleus http://togogenome.org/gene/9595:TAF1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZUH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF1 family.|||Nucleus http://togogenome.org/gene/9595:NUBP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YWT3|||http://purl.uniprot.org/uniprot/G3QF82 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.|||Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.|||Cell projection|||Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.|||Cytoplasm|||Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1. http://togogenome.org/gene/9595:XAGE2 ^@ http://purl.uniprot.org/uniprot/G3S4Q2 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9595:IRF9 ^@ http://purl.uniprot.org/uniprot/G3RIY4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:HTR3E ^@ http://purl.uniprot.org/uniprot/G3SG94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane http://togogenome.org/gene/9595:ZRANB2 ^@ http://purl.uniprot.org/uniprot/G3RPF8|||http://purl.uniprot.org/uniprot/G3SJM9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZRANB2 family.|||Nucleus|||Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection. http://togogenome.org/gene/9595:SF3B3 ^@ http://purl.uniprot.org/uniprot/G3QL55 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:LAMP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YGB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9595:LOC101128292 ^@ http://purl.uniprot.org/uniprot/G3QUL4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9595:LOC101149433 ^@ http://purl.uniprot.org/uniprot/G3REX0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SURF1 family.|||Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:CDK4 ^@ http://purl.uniprot.org/uniprot/G3QGD2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:USP5 ^@ http://purl.uniprot.org/uniprot/G3QJI4 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9595:NEDD9 ^@ http://purl.uniprot.org/uniprot/G3RJJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAS family.|||focal adhesion http://togogenome.org/gene/9595:OPTC ^@ http://purl.uniprot.org/uniprot/G3RIQ6 ^@ Similarity ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. http://togogenome.org/gene/9595:ABCG1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZSG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/9595:CDC42BPG ^@ http://purl.uniprot.org/uniprot/G3QDM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.|||Cytoplasm http://togogenome.org/gene/9595:S100Z ^@ http://purl.uniprot.org/uniprot/G3SJ08 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9595:CLSPN ^@ http://purl.uniprot.org/uniprot/G3QT52 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:MAP3K14 ^@ http://purl.uniprot.org/uniprot/G3QPG2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Cytoplasm|||Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. http://togogenome.org/gene/9595:C3H3orf70 ^@ http://purl.uniprot.org/uniprot/A0A2I2YBZ6 ^@ Similarity ^@ Belongs to the UPF0524 family. http://togogenome.org/gene/9595:ST3GAL1 ^@ http://purl.uniprot.org/uniprot/G3RUZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9595:GGPS1 ^@ http://purl.uniprot.org/uniprot/G3R0L0 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9595:LOC101150071 ^@ http://purl.uniprot.org/uniprot/G3R7H3 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9595:ATL2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z6Z3|||http://purl.uniprot.org/uniprot/A0A2I2ZE35 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9595:SEZ6L2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YBM4|||http://purl.uniprot.org/uniprot/A0A2I2YE58|||http://purl.uniprot.org/uniprot/G3RHW1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:AKR1A1 ^@ http://purl.uniprot.org/uniprot/G3RAF6 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the aldo/keto reductase family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/9595:CEP76 ^@ http://purl.uniprot.org/uniprot/G3QZM3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP76 family.|||Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.|||centriole http://togogenome.org/gene/9595:TMEM182 ^@ http://purl.uniprot.org/uniprot/A0A2I2YIZ6|||http://purl.uniprot.org/uniprot/A0A2I2Z694 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM182 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ATP5MF ^@ http://purl.uniprot.org/uniprot/A0A2I2YV24|||http://purl.uniprot.org/uniprot/A0A2I2ZCK3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase F chain family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:NSG2 ^@ http://purl.uniprot.org/uniprot/G3RAX5 ^@ Similarity ^@ Belongs to the NSG family. http://togogenome.org/gene/9595:STAMBP ^@ http://purl.uniprot.org/uniprot/G3RXN2 ^@ Similarity ^@ Belongs to the peptidase M67C family. http://togogenome.org/gene/9595:ACLY ^@ http://purl.uniprot.org/uniprot/A0A2I2Y4J2|||http://purl.uniprot.org/uniprot/A0A2I2ZLM6 ^@ Function|||Similarity|||Subunit ^@ Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.|||Homotetramer.|||In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.|||In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. http://togogenome.org/gene/9595:PLPP3 ^@ http://purl.uniprot.org/uniprot/G3QDI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9595:PTPRU ^@ http://purl.uniprot.org/uniprot/G3QTZ2|||http://purl.uniprot.org/uniprot/G3SAR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.|||Membrane http://togogenome.org/gene/9595:MYO19 ^@ http://purl.uniprot.org/uniprot/G3QY42 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9595:CTNNBIP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YTS2 ^@ Similarity ^@ Belongs to the CTNNBIP1 family. http://togogenome.org/gene/9595:HEPH ^@ http://purl.uniprot.org/uniprot/G3R124 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/9595:NOX1 ^@ http://purl.uniprot.org/uniprot/G3QVH2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:RGMA ^@ http://purl.uniprot.org/uniprot/G3SH90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the repulsive guidance molecule (RGM) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:CDR2L ^@ http://purl.uniprot.org/uniprot/G3S4H3 ^@ Similarity ^@ Belongs to the CDR2 family. http://togogenome.org/gene/9595:KRT32 ^@ http://purl.uniprot.org/uniprot/G3RL19 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:DPCD ^@ http://purl.uniprot.org/uniprot/G3QQQ9 ^@ Similarity ^@ Belongs to the DPCD family. http://togogenome.org/gene/9595:TBX15 ^@ http://purl.uniprot.org/uniprot/G3RCB5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9595:IL23A ^@ http://purl.uniprot.org/uniprot/G3QH19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-6 superfamily.|||Secreted http://togogenome.org/gene/9595:NAA10 ^@ http://purl.uniprot.org/uniprot/G3R2U7 ^@ Similarity ^@ Belongs to the acetyltransferase family. ARD1 subfamily. http://togogenome.org/gene/9595:FTSJ3 ^@ http://purl.uniprot.org/uniprot/G3QV89 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.|||Interacts with NIP7.|||Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.|||nucleolus http://togogenome.org/gene/9595:MDN1 ^@ http://purl.uniprot.org/uniprot/G3SD94 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the midasin family.|||Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9595:GMNN ^@ http://purl.uniprot.org/uniprot/G3R2B4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the geminin family.|||Nucleus http://togogenome.org/gene/9595:LOC101152722 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZM97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX17 family.|||Mitochondrion intermembrane space http://togogenome.org/gene/9595:SEC61A1 ^@ http://purl.uniprot.org/uniprot/G3RUZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:HMGN2 ^@ http://purl.uniprot.org/uniprot/G3QF88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/9595:FIS1 ^@ http://purl.uniprot.org/uniprot/G3R091 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FIS1 family.|||Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.|||Membrane|||Mitochondrion outer membrane|||The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission. http://togogenome.org/gene/9595:DKC1 ^@ http://purl.uniprot.org/uniprot/G3RNN2 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/9595:MRC2 ^@ http://purl.uniprot.org/uniprot/G3QHG6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:AP4M1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z0A9|||http://purl.uniprot.org/uniprot/G3QJU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos. The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal.|||Early endosome|||trans-Golgi network membrane http://togogenome.org/gene/9595:GRK7 ^@ http://purl.uniprot.org/uniprot/G3RBR7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9595:KRT82 ^@ http://purl.uniprot.org/uniprot/G3QJZ6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:TUT1 ^@ http://purl.uniprot.org/uniprot/G3RCJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B-like family.|||Nucleus speckle|||nucleolus http://togogenome.org/gene/9595:CTLA4 ^@ http://purl.uniprot.org/uniprot/G3QY54|||http://purl.uniprot.org/uniprot/G3S368 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.|||Membrane http://togogenome.org/gene/9595:URAD ^@ http://purl.uniprot.org/uniprot/G3QRV7 ^@ Function|||Similarity ^@ Belongs to the OHCU decarboxylase family.|||Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin. http://togogenome.org/gene/9595:PDE5A ^@ http://purl.uniprot.org/uniprot/G3RCX2 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9595:NCAPD3 ^@ http://purl.uniprot.org/uniprot/G3QV81 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the condensin-2 complex.|||Nucleus|||Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. http://togogenome.org/gene/9595:OLFM3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YBG7|||http://purl.uniprot.org/uniprot/G3RLQ0 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/9595:ADM ^@ http://purl.uniprot.org/uniprot/G3R6L3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adrenomedullin family.|||Secreted http://togogenome.org/gene/9595:SLC25A44 ^@ http://purl.uniprot.org/uniprot/G3R5Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9595:SLCO6A1 ^@ http://purl.uniprot.org/uniprot/G3RFJ2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:ALOX12B ^@ http://purl.uniprot.org/uniprot/G3QSI2 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the lipoxygenase family.|||Binds 1 Fe cation per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:ATP5MC3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z561 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/9595:RUVBL2 ^@ http://purl.uniprot.org/uniprot/G3R1H0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RuvB family.|||Dynein axonemal particle|||Nucleus|||Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. http://togogenome.org/gene/9595:PLXND1 ^@ http://purl.uniprot.org/uniprot/G3QEM8 ^@ Caution|||Similarity ^@ Belongs to the plexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:PTGR1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z9P7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADP-dependent oxidoreductase L4BD family.|||Cytoplasm|||Monomer or homodimer. http://togogenome.org/gene/9595:LOC101152497 ^@ http://purl.uniprot.org/uniprot/G3SK68 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/9595:GABRP ^@ http://purl.uniprot.org/uniprot/G3QMM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9595:LOC101129836 ^@ http://purl.uniprot.org/uniprot/G3QI19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:HDAC6 ^@ http://purl.uniprot.org/uniprot/G3QPF0 ^@ Similarity ^@ Belongs to the histone deacetylase family. HD type 2 subfamily. http://togogenome.org/gene/9595:DPYS ^@ http://purl.uniprot.org/uniprot/G3QDD2 ^@ PTM|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.|||Carbamylation allows a single lysine to coordinate two divalent metal cations. http://togogenome.org/gene/9595:PRDM13 ^@ http://purl.uniprot.org/uniprot/G3QVL8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:BSX ^@ http://purl.uniprot.org/uniprot/G3QU78 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:CNTFR ^@ http://purl.uniprot.org/uniprot/G3QUF2 ^@ Similarity ^@ Belongs to the type I cytokine receptor family. Type 3 subfamily. http://togogenome.org/gene/9595:METTL14 ^@ http://purl.uniprot.org/uniprot/A0A2I2YEF1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MT-A70-like family.|||Heterodimer; heterodimerizes with METTL3 to form an antiparallel heterodimer that constitutes an active methyltransferase.|||Nucleus|||The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation. In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization. M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis. M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells. http://togogenome.org/gene/9595:DNPEP ^@ http://purl.uniprot.org/uniprot/A0A2I2ZMW2 ^@ Similarity|||Subunit ^@ Belongs to the peptidase M18 family.|||Tetrahedron-shaped homododecamer built from six homodimers. http://togogenome.org/gene/9595:PLOD3 ^@ http://purl.uniprot.org/uniprot/G3RN67 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9595:LOC101141699 ^@ http://purl.uniprot.org/uniprot/G3QIY6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:DMRT3 ^@ http://purl.uniprot.org/uniprot/G3RBV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/9595:BSCL2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z3C5 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:PLXNC1 ^@ http://purl.uniprot.org/uniprot/G3RQ81 ^@ Caution|||Similarity ^@ Belongs to the plexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:CADM2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YGT2|||http://purl.uniprot.org/uniprot/G3S6D6 ^@ Similarity ^@ Belongs to the nectin family. http://togogenome.org/gene/9595:HAPLN3 ^@ http://purl.uniprot.org/uniprot/G3QRC2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:GPR33 ^@ http://purl.uniprot.org/uniprot/G3S0S2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:SYF2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YYX6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SYF2 family.|||Involved in pre-mRNA splicing.|||May be part of a spliceosome complex.|||Nucleus http://togogenome.org/gene/9595:SERPINA5 ^@ http://purl.uniprot.org/uniprot/G3QHK3 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9595:ASPA ^@ http://purl.uniprot.org/uniprot/G3QQC1 ^@ Cofactor|||Similarity ^@ Belongs to the AspA/AstE family. Aspartoacylase subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9595:NUP205 ^@ http://purl.uniprot.org/uniprot/G3R7B7 ^@ Similarity ^@ Belongs to the NUP186/NUP192/NUP205 family. http://togogenome.org/gene/9595:RARS2 ^@ http://purl.uniprot.org/uniprot/G3R3G7 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9595:REXO4 ^@ http://purl.uniprot.org/uniprot/G3RF01 ^@ Similarity ^@ Belongs to the REXO4 family. http://togogenome.org/gene/9595:AUH ^@ http://purl.uniprot.org/uniprot/G3QML4 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9595:PADI2 ^@ http://purl.uniprot.org/uniprot/G3RJJ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein arginine deiminase family.|||Catalyzes the deimination of arginine residues of proteins.|||Cytoplasm http://togogenome.org/gene/9595:LOC101124851 ^@ http://purl.uniprot.org/uniprot/G3QVG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9595:AGXT2 ^@ http://purl.uniprot.org/uniprot/G3QUN3 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9595:CORO2A ^@ http://purl.uniprot.org/uniprot/G3R1C7 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/9595:SLC22A9 ^@ http://purl.uniprot.org/uniprot/G3SB06 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:LOC101136745 ^@ http://purl.uniprot.org/uniprot/G3R5W3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ATF1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZEL8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:ITGA10 ^@ http://purl.uniprot.org/uniprot/G3RHC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9595:DPYSL3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YG83|||http://purl.uniprot.org/uniprot/G3S4K1 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/9595:EIF2A ^@ http://purl.uniprot.org/uniprot/A0A2I2ZFS3 ^@ Function|||Similarity ^@ Belongs to the WD repeat EIF2A family.|||Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. http://togogenome.org/gene/9595:IL9 ^@ http://purl.uniprot.org/uniprot/G3RE08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-7/IL-9 family.|||Secreted http://togogenome.org/gene/9595:EIF5A2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YC22 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Endoplasmic reticulum membrane|||Membrane|||Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.|||eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group. http://togogenome.org/gene/9595:GNB2 ^@ http://purl.uniprot.org/uniprot/G3QSP3 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/9595:PEX12 ^@ http://purl.uniprot.org/uniprot/G3QLC4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pex2/pex10/pex12 family.|||Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9595:LOC109029095 ^@ http://purl.uniprot.org/uniprot/A0A2I2YEJ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9595:NPVF ^@ http://purl.uniprot.org/uniprot/G3R8I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FARP (FMRFamide related peptide) family.|||Secreted http://togogenome.org/gene/9595:TRMT112 ^@ http://purl.uniprot.org/uniprot/G3QG66 ^@ Similarity ^@ Belongs to the TRM112 family. http://togogenome.org/gene/9595:HTR3A ^@ http://purl.uniprot.org/uniprot/A0A2I2ZB92|||http://purl.uniprot.org/uniprot/G3RFI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:FAM161A ^@ http://purl.uniprot.org/uniprot/G3RDJ6|||http://purl.uniprot.org/uniprot/G3S668 ^@ Similarity ^@ Belongs to the FAM161 family. http://togogenome.org/gene/9595:ABCD1 ^@ http://purl.uniprot.org/uniprot/G3QS26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9595:NRCAM ^@ http://purl.uniprot.org/uniprot/A0A2I2YVR5|||http://purl.uniprot.org/uniprot/A0A2I2ZHX1|||http://purl.uniprot.org/uniprot/A0A2I2ZM62|||http://purl.uniprot.org/uniprot/A0A2I2ZNL1 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. http://togogenome.org/gene/9595:PLCD1 ^@ http://purl.uniprot.org/uniprot/G3QMJ5|||http://purl.uniprot.org/uniprot/G3RXS3 ^@ Cofactor ^@ Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain. http://togogenome.org/gene/9595:LOC109028370 ^@ http://purl.uniprot.org/uniprot/G3QR34 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:TBX21 ^@ http://purl.uniprot.org/uniprot/G3QIG3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9595:MAP4K2 ^@ http://purl.uniprot.org/uniprot/G3QKE8 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. http://togogenome.org/gene/9595:NDUFAB1 ^@ http://purl.uniprot.org/uniprot/Q0MQC2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain. Accessory protein, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with LYRM4, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (By similarity). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity).|||Mammalian complex I is composed of 45 different subunits. Interacts with ETFRF1. Identified in a complex composed of MALSU1, MIEF1 upstream open reading frame protein and NDUFAB1; within the trimeric complex, MIEF1 upstream open reading frame protein functions as a bridging scaffold that interacts with MALSU1 on one side, and with NDUFAB1 on the other side. The complex interacts with the mitochondrial large ribosomal subunit. Interacts with alpha-1-microglobulin chain; this interaction is required for the maintenance of mitochondrial redox homeostasis. Component of the mitochondrial core iron-sulfur cluster (ISC) complex composed of NFS1, LYRM4, NDUFAB1, ISCU, FXN, and FDX2; this complex is an heterohexamer containing two copies of each monomer. Component of the cyteine desulfurase complex composed of NFS1, LYRM4 and NDUFAB1; this complex contributes to the stability and cysteine desulfurase activity of NFS1.|||Mitochondrion|||Phosphopantetheinylation at Ser-112 is essential for interactions with LYR motif-containing proteins. http://togogenome.org/gene/9595:ANKRD34B ^@ http://purl.uniprot.org/uniprot/A0A2I2ZNV7 ^@ Similarity ^@ Belongs to the ANKRD34 family. http://togogenome.org/gene/9595:LEUTX ^@ http://purl.uniprot.org/uniprot/A0A2I2ZWG8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:HAO2 ^@ http://purl.uniprot.org/uniprot/G3R1D9 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/9595:GPM6A ^@ http://purl.uniprot.org/uniprot/A0A2I2YM05|||http://purl.uniprot.org/uniprot/A0A2I2ZRH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/9595:LOC101138472 ^@ http://purl.uniprot.org/uniprot/G3RKB0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9595:PDHB ^@ http://purl.uniprot.org/uniprot/A0A2I2Y532|||http://purl.uniprot.org/uniprot/G3RBH2 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. http://togogenome.org/gene/9595:RNF40 ^@ http://purl.uniprot.org/uniprot/G3RKQ1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BRE1 family.|||Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.|||Nucleus http://togogenome.org/gene/9595:FMO3 ^@ http://purl.uniprot.org/uniprot/G3RKD7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.|||Membrane|||Microsome membrane http://togogenome.org/gene/9595:OSBPL2 ^@ http://purl.uniprot.org/uniprot/G3QZF0 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9595:GPRIN2 ^@ http://purl.uniprot.org/uniprot/G3RB88 ^@ Function ^@ May be involved in neurite outgrowth. http://togogenome.org/gene/9595:ZNF213 ^@ http://purl.uniprot.org/uniprot/G3R8L7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:NXPH4 ^@ http://purl.uniprot.org/uniprot/G3R3Z9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/9595:NT5DC2 ^@ http://purl.uniprot.org/uniprot/G3RIT6 ^@ Cofactor|||Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/9595:HESX1 ^@ http://purl.uniprot.org/uniprot/G3QTP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ANF homeobox family.|||Nucleus http://togogenome.org/gene/9595:ATP13A5 ^@ http://purl.uniprot.org/uniprot/G3QVW2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:RBM47 ^@ http://purl.uniprot.org/uniprot/G3S7F5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM RBM47 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:TMEM35B ^@ http://purl.uniprot.org/uniprot/G3S3L5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Membrane http://togogenome.org/gene/9595:MEGF6 ^@ http://purl.uniprot.org/uniprot/G3RQW9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:TRPM6 ^@ http://purl.uniprot.org/uniprot/A0A2I2YQ50|||http://purl.uniprot.org/uniprot/G3SJI9 ^@ Similarity|||Subcellular Location Annotation ^@ In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.|||Membrane http://togogenome.org/gene/9595:LOC101147918 ^@ http://purl.uniprot.org/uniprot/G3QXZ8 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9595:SYPL2 ^@ http://purl.uniprot.org/uniprot/G3RC44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/9595:PCNX4 ^@ http://purl.uniprot.org/uniprot/G3SD25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pecanex family.|||Membrane http://togogenome.org/gene/9595:ADPRS ^@ http://purl.uniprot.org/uniprot/G3QMG4 ^@ Similarity ^@ Belongs to the ADP-ribosylglycohydrolase family. http://togogenome.org/gene/9595:CDPF1 ^@ http://purl.uniprot.org/uniprot/G3SJ38 ^@ Similarity ^@ Belongs to the CDPF1 family. http://togogenome.org/gene/9595:TOMM7 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y7Q0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom7 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9595:CMAS ^@ http://purl.uniprot.org/uniprot/G3RGF5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CMP-NeuNAc synthase family.|||Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).|||Homotetramer; the active enzyme is formed by a dimer of dimers. http://togogenome.org/gene/9595:LOC101129087 ^@ http://purl.uniprot.org/uniprot/G3R3C3 ^@ Similarity ^@ Belongs to the NUT family. http://togogenome.org/gene/9595:LGI1 ^@ http://purl.uniprot.org/uniprot/G3QIJ9 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9595:RETREG1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y1L7|||http://purl.uniprot.org/uniprot/G3R4Y4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RETREG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:CCSER1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YN34|||http://purl.uniprot.org/uniprot/G3RDV0 ^@ Similarity ^@ Belongs to the CCSER family. http://togogenome.org/gene/9595:WDR91 ^@ http://purl.uniprot.org/uniprot/G3QF22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR91 family.|||Early endosome membrane|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9595:SV2C ^@ http://purl.uniprot.org/uniprot/G3QXL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/9595:ELP3 ^@ http://purl.uniprot.org/uniprot/G3QQ56 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ELP3 family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. http://togogenome.org/gene/9595:TRIM9 ^@ http://purl.uniprot.org/uniprot/G3QS61 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9595:HSPH1 ^@ http://purl.uniprot.org/uniprot/G3S272 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 70 family.|||Cytoplasm http://togogenome.org/gene/9595:RPL38 ^@ http://purl.uniprot.org/uniprot/G3QET2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL38 family. http://togogenome.org/gene/9595:TFAP2A ^@ http://purl.uniprot.org/uniprot/A0A2I2Y2H6|||http://purl.uniprot.org/uniprot/A0A2I2Y342|||http://purl.uniprot.org/uniprot/G3QX48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AP-2 family.|||Nucleus http://togogenome.org/gene/9595:DTX3L ^@ http://purl.uniprot.org/uniprot/G3RIS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Deltex family.|||Cytoplasm http://togogenome.org/gene/9595:TUT7 ^@ http://purl.uniprot.org/uniprot/G3SAU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B-like family.|||Cytoplasm http://togogenome.org/gene/9595:PADI4 ^@ http://purl.uniprot.org/uniprot/G3RGW5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein arginine deiminase family.|||Catalyzes the deimination of arginine residues of proteins.|||Cytoplasm http://togogenome.org/gene/9595:S100A5 ^@ http://purl.uniprot.org/uniprot/G3QWD1 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9595:UBL4A ^@ http://purl.uniprot.org/uniprot/G3RQ50 ^@ Subcellular Location Annotation ^@ cytosol http://togogenome.org/gene/9595:FAM167B ^@ http://purl.uniprot.org/uniprot/G3S571 ^@ Similarity ^@ Belongs to the FAM167 (SEC) family. http://togogenome.org/gene/9595:MAP1LC3C ^@ http://purl.uniprot.org/uniprot/G3QDD6 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9595:CYRIB ^@ http://purl.uniprot.org/uniprot/G3SFG7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CYRI family.|||Interacts with RAC1 (GTP-bound form preferentially).|||Membrane http://togogenome.org/gene/9595:TCEA2 ^@ http://purl.uniprot.org/uniprot/G3QMP6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family.|||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.|||Nucleus http://togogenome.org/gene/9595:BAMBI ^@ http://purl.uniprot.org/uniprot/G3QPL0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BAMBI family.|||Membrane|||Negatively regulates TGF-beta signaling. http://togogenome.org/gene/9595:ANXA6 ^@ http://purl.uniprot.org/uniprot/G3QQY3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.|||Melanosome http://togogenome.org/gene/9595:NDUFA4 ^@ http://purl.uniprot.org/uniprot/Q0MQ98 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex IV NDUFA4 subunit family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Interacts with RAB5IF (By similarity). Interacts with FLVCR2; this interaction occurs in the absence of heme and is disrupted upon heme binding.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. NDUFA4 is required for complex IV maintenance.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:KCND3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YJE5|||http://purl.uniprot.org/uniprot/G3RHS4 ^@ Subcellular Location Annotation ^@ Membrane|||dendrite http://togogenome.org/gene/9595:TMEM144 ^@ http://purl.uniprot.org/uniprot/G3RLJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM144 family.|||Membrane http://togogenome.org/gene/9595:DLX1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZN57 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SLC19A3 ^@ http://purl.uniprot.org/uniprot/G3QNY1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.|||Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity.|||Membrane http://togogenome.org/gene/9595:CASS4 ^@ http://purl.uniprot.org/uniprot/G3QNL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAS family.|||focal adhesion http://togogenome.org/gene/9595:CASP8 ^@ http://purl.uniprot.org/uniprot/A0A2I2YHY1 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9595:ABCB11 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z8S9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:IQCG ^@ http://purl.uniprot.org/uniprot/A0A2I2Z7X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC9 family.|||flagellum|||flagellum axoneme http://togogenome.org/gene/9595:CTNS ^@ http://purl.uniprot.org/uniprot/A0A2I2Y463|||http://purl.uniprot.org/uniprot/G3R346 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cystinosin family.|||Membrane http://togogenome.org/gene/9595:OTULINL ^@ http://purl.uniprot.org/uniprot/G3RDP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C65 family. Otulin subfamily.|||Cytoplasm http://togogenome.org/gene/9595:RAB33A ^@ http://purl.uniprot.org/uniprot/G3SBQ8 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Rab family. http://togogenome.org/gene/9595:IRF1 ^@ http://purl.uniprot.org/uniprot/G3RDI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Nucleus http://togogenome.org/gene/9595:LOC101129723 ^@ http://purl.uniprot.org/uniprot/A1YF15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus|||Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity (By similarity). http://togogenome.org/gene/9595:TNFSF4 ^@ http://purl.uniprot.org/uniprot/G3RRJ0 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9595:MTFR1 ^@ http://purl.uniprot.org/uniprot/G3QWY8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission. http://togogenome.org/gene/9595:LOC101142110 ^@ http://purl.uniprot.org/uniprot/G3R0R8 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9595:PTGES3L ^@ http://purl.uniprot.org/uniprot/A0A2I2Y205 ^@ Similarity ^@ Belongs to the p23/wos2 family. http://togogenome.org/gene/9595:BCL2L1 ^@ http://purl.uniprot.org/uniprot/G3RY91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Membrane|||Mitochondrion matrix|||Nucleus membrane|||centrosome|||cytosol|||synaptic vesicle membrane http://togogenome.org/gene/9595:GUCY2F ^@ http://purl.uniprot.org/uniprot/G3QV59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane|||Photoreceptor outer segment membrane http://togogenome.org/gene/9595:UNK ^@ http://purl.uniprot.org/uniprot/G3R1E1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unkempt family.|||Cytoplasm http://togogenome.org/gene/9595:TMEM237 ^@ http://purl.uniprot.org/uniprot/G3QPW8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM237 family.|||Component of the transition zone in primary cilia. Required for ciliogenesis.|||Membrane|||cilium http://togogenome.org/gene/9595:TMOD4 ^@ http://purl.uniprot.org/uniprot/G3S261 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9595:TRHR ^@ http://purl.uniprot.org/uniprot/G3RKI5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. http://togogenome.org/gene/9595:LOC101147034 ^@ http://purl.uniprot.org/uniprot/G3QTN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/9595:CUL4A ^@ http://purl.uniprot.org/uniprot/A0A2I2Z909|||http://purl.uniprot.org/uniprot/G3QDT2 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9595:NDUFA11 ^@ http://purl.uniprot.org/uniprot/Q0MQB9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA11 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:APOO ^@ http://purl.uniprot.org/uniprot/G3QFV2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:LOC101154451 ^@ http://purl.uniprot.org/uniprot/G3RU19 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9595:PSMA1 ^@ http://purl.uniprot.org/uniprot/G3QGE3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9595:GSTZ1 ^@ http://purl.uniprot.org/uniprot/G3QTP9|||http://purl.uniprot.org/uniprot/G3S5A6 ^@ Similarity ^@ Belongs to the GST superfamily. Zeta family. http://togogenome.org/gene/9595:ZC3H12B ^@ http://purl.uniprot.org/uniprot/G3SK26 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/9595:EFNA4 ^@ http://purl.uniprot.org/uniprot/G3RDG1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:S100PBP ^@ http://purl.uniprot.org/uniprot/G3QS48 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:CCNL2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z213|||http://purl.uniprot.org/uniprot/G3QYV8 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9595:ARPP19 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y2C8|||http://purl.uniprot.org/uniprot/A0A2I2ZT76 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endosulfine family.|||Cytoplasm|||Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. http://togogenome.org/gene/9595:H1-3 ^@ http://purl.uniprot.org/uniprot/G3QW70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9595:NPAS4 ^@ http://purl.uniprot.org/uniprot/G3QZU8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:CMTM2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZS98 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:TCEAL1 ^@ http://purl.uniprot.org/uniprot/A1YEW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family. TFA subfamily.|||May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. Does not bind DNA directly (By similarity).|||Nucleus http://togogenome.org/gene/9595:PNKD ^@ http://purl.uniprot.org/uniprot/G3QVH5 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. http://togogenome.org/gene/9595:LOC101128201 ^@ http://purl.uniprot.org/uniprot/G3SI94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:LSM5 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZH19 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. http://togogenome.org/gene/9595:PEX19 ^@ http://purl.uniprot.org/uniprot/G3S3F0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxin-19 family.|||Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.|||Membrane|||Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.|||Peroxisome membrane http://togogenome.org/gene/9595:EIF2B4 ^@ http://purl.uniprot.org/uniprot/G3R5X2 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/9595:GBP2 ^@ http://purl.uniprot.org/uniprot/G3QH70 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9595:TEKT5 ^@ http://purl.uniprot.org/uniprot/G3QVU5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/9595:TAAR5 ^@ http://purl.uniprot.org/uniprot/G3QZ92 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:POT1 ^@ http://purl.uniprot.org/uniprot/G3RFG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the telombin family.|||Nucleus|||telomere http://togogenome.org/gene/9595:CALCA ^@ http://purl.uniprot.org/uniprot/G3RE30 ^@ Similarity ^@ Belongs to the calcitonin family. http://togogenome.org/gene/9595:CEP55 ^@ http://purl.uniprot.org/uniprot/A0A2I2YRV3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:TIMM10 ^@ http://purl.uniprot.org/uniprot/G3R9P2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9595:SLC12A4 ^@ http://purl.uniprot.org/uniprot/A0A2I2YNR3|||http://purl.uniprot.org/uniprot/A0A2I2ZJH0|||http://purl.uniprot.org/uniprot/A0A2I2ZQL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9595:NPM1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YQY6|||http://purl.uniprot.org/uniprot/G3QWA8 ^@ Similarity ^@ Belongs to the nucleoplasmin family. http://togogenome.org/gene/9595:HOXB1 ^@ http://purl.uniprot.org/uniprot/G3R355 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Labial subfamily.|||Nucleus http://togogenome.org/gene/9595:EPN2 ^@ http://purl.uniprot.org/uniprot/G3RLB9|||http://purl.uniprot.org/uniprot/G3RRH0 ^@ Similarity ^@ Belongs to the epsin family. http://togogenome.org/gene/9595:HIGD2B ^@ http://purl.uniprot.org/uniprot/G3RH47 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/9595:WDR83OS ^@ http://purl.uniprot.org/uniprot/G3RC27 ^@ Similarity ^@ Belongs to the Asterix family. http://togogenome.org/gene/9595:SUPT6H ^@ http://purl.uniprot.org/uniprot/G3RKN0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT6 family.|||Nucleus|||Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). http://togogenome.org/gene/9595:PSIP1 ^@ http://purl.uniprot.org/uniprot/G3RJ84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HDGF family.|||Nucleus http://togogenome.org/gene/9595:FOXL1 ^@ http://purl.uniprot.org/uniprot/G3RF46 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:MGP ^@ http://purl.uniprot.org/uniprot/A0A2I2Z0Z1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.|||Belongs to the osteocalcin/matrix Gla protein family.|||Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.|||Requires vitamin K-dependent gamma-carboxylation for its function.|||Secreted http://togogenome.org/gene/9595:SMDT1 ^@ http://purl.uniprot.org/uniprot/G3QY06 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMDT1/EMRE family.|||Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.|||Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9595:ZDHHC5 ^@ http://purl.uniprot.org/uniprot/G3QDT7 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9595:LTBR ^@ http://purl.uniprot.org/uniprot/G3R5J9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:LOC101130647 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z622 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:IL10 ^@ http://purl.uniprot.org/uniprot/G3REF8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/9595:ZCCHC4 ^@ http://purl.uniprot.org/uniprot/G3S195 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZCCHC4 family.|||Cytoplasm|||nucleolus http://togogenome.org/gene/9595:HSPA5 ^@ http://purl.uniprot.org/uniprot/G3S6H1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 70 family.|||Cell surface|||Endoplasmic reticulum lumen|||Melanosome http://togogenome.org/gene/9595:RAB5IF ^@ http://purl.uniprot.org/uniprot/G3RXB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMC6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:LOC101128885 ^@ http://purl.uniprot.org/uniprot/G3QPL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:AMD1 ^@ http://purl.uniprot.org/uniprot/G3QUC4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic AdoMetDC family.|||Binds 1 pyruvoyl group covalently per subunit.|||Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.|||Heterotetramer of two alpha and two beta chains. http://togogenome.org/gene/9595:MFGE8 ^@ http://purl.uniprot.org/uniprot/G3RF38 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:DNM1L ^@ http://purl.uniprot.org/uniprot/A0A2I2Z6J7|||http://purl.uniprot.org/uniprot/A0A2I2ZBB8|||http://purl.uniprot.org/uniprot/A0A2I2ZQQ6|||http://purl.uniprot.org/uniprot/G3SH34 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/9595:LOC101138548 ^@ http://purl.uniprot.org/uniprot/G3QSL7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9595:TMCC2 ^@ http://purl.uniprot.org/uniprot/G3S0X2 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/9595:SLC22A5 ^@ http://purl.uniprot.org/uniprot/G3QFF2|||http://purl.uniprot.org/uniprot/G3RTQ5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Basal cell membrane|||Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.|||Cell membrane|||Interacts with PDZK1. http://togogenome.org/gene/9595:ALDOB ^@ http://purl.uniprot.org/uniprot/A0A2I2ZJH2 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/9595:HEATR1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z2B1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HEATR1/UTP10 family.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/9595:ADD3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZPJ2|||http://purl.uniprot.org/uniprot/G3RP35 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/9595:DDR1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YE95|||http://purl.uniprot.org/uniprot/G3RFJ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:RCAN3 ^@ http://purl.uniprot.org/uniprot/G3RC15 ^@ Similarity ^@ Belongs to the RCAN family. http://togogenome.org/gene/9595:PPP4R3C ^@ http://purl.uniprot.org/uniprot/G3S742 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/9595:LSM7 ^@ http://purl.uniprot.org/uniprot/G3R3U1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus http://togogenome.org/gene/9595:RPS5 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z9R5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS7 family. http://togogenome.org/gene/9595:TPH1 ^@ http://purl.uniprot.org/uniprot/G3RMB3 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/9595:PHKA2 ^@ http://purl.uniprot.org/uniprot/G3S081 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.|||Belongs to the phosphorylase b kinase regulatory chain family.|||Cell membrane|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.|||Membrane|||Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. http://togogenome.org/gene/9595:HOXA2 ^@ http://purl.uniprot.org/uniprot/G3QIG7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:MRPL46 ^@ http://purl.uniprot.org/uniprot/G3RGM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL46 family.|||Mitochondrion http://togogenome.org/gene/9595:MFF ^@ http://purl.uniprot.org/uniprot/A0A2I2YW07|||http://purl.uniprot.org/uniprot/A0A2I2ZM93|||http://purl.uniprot.org/uniprot/G3RL80 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Tango11 family.|||Membrane|||Mitochondrion outer membrane|||Peroxisome|||Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.|||synaptic vesicle http://togogenome.org/gene/9595:RDH14 ^@ http://purl.uniprot.org/uniprot/G3R8I8 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9595:GGA1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z8T1|||http://purl.uniprot.org/uniprot/G3RF82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GGA protein family.|||Early endosome membrane|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9595:PRRX1 ^@ http://purl.uniprot.org/uniprot/G3R3W3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/9595:LOC109024295 ^@ http://purl.uniprot.org/uniprot/G3S6W7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/9595:UTP25 ^@ http://purl.uniprot.org/uniprot/G3QTQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP25 family.|||nucleolus http://togogenome.org/gene/9595:LOC101151505 ^@ http://purl.uniprot.org/uniprot/A0A2I2YSK2|||http://purl.uniprot.org/uniprot/A0A2I2ZCP3|||http://purl.uniprot.org/uniprot/A0A2I2ZMB1 ^@ Similarity ^@ Belongs to the GroES chaperonin family.|||Belongs to the MOB1/phocein family. http://togogenome.org/gene/9595:CD79B ^@ http://purl.uniprot.org/uniprot/A0A2I2YUB3|||http://purl.uniprot.org/uniprot/G3R9W5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:ST8SIA1 ^@ http://purl.uniprot.org/uniprot/G3QGC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9595:KCNK18 ^@ http://purl.uniprot.org/uniprot/G3SCI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9595:LACC1 ^@ http://purl.uniprot.org/uniprot/G3R0P4 ^@ Similarity ^@ Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family. http://togogenome.org/gene/9595:EXT2 ^@ http://purl.uniprot.org/uniprot/G3R5A6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:KCTD13 ^@ http://purl.uniprot.org/uniprot/G3RHW8 ^@ Similarity ^@ Belongs to the BACURD family. http://togogenome.org/gene/9595:SLC30A2 ^@ http://purl.uniprot.org/uniprot/G3RJW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9595:MS4A6A ^@ http://purl.uniprot.org/uniprot/G3RGN9 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9595:BDKRB2 ^@ http://purl.uniprot.org/uniprot/G3RCA6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.|||Membrane|||Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9595:FXYD3 ^@ http://purl.uniprot.org/uniprot/G3SIJ8 ^@ Caution|||Similarity ^@ Belongs to the FXYD family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:CR2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y6U3|||http://purl.uniprot.org/uniprot/G3QLP1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:LOC101123729 ^@ http://purl.uniprot.org/uniprot/G3QT24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9595:APH1B ^@ http://purl.uniprot.org/uniprot/A0A2I2ZC70 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the APH-1 family.|||Component of the gamma-secretase complex.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. http://togogenome.org/gene/9595:HCN3 ^@ http://purl.uniprot.org/uniprot/G3RJ51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel HCN family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:LNPK ^@ http://purl.uniprot.org/uniprot/G3QXW4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the lunapark family.|||Endoplasmic reticulum membrane|||Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.|||Plays a role in determining ER morphology.|||The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation. http://togogenome.org/gene/9595:RNMT ^@ http://purl.uniprot.org/uniprot/G3QRZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.|||In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.|||Nucleus http://togogenome.org/gene/9595:NOP10 ^@ http://purl.uniprot.org/uniprot/G3QFH4 ^@ Similarity ^@ Belongs to the NOP10 family. http://togogenome.org/gene/9595:ALOX15B ^@ http://purl.uniprot.org/uniprot/G3REL4 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the lipoxygenase family.|||Binds 1 Fe cation per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:CD93 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZW40 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:SS18 ^@ http://purl.uniprot.org/uniprot/A0A2I2YW77|||http://purl.uniprot.org/uniprot/G3QP88 ^@ Similarity ^@ Belongs to the SS18 family. http://togogenome.org/gene/9595:LPAR5 ^@ http://purl.uniprot.org/uniprot/G3QHS3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:SLC35A2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y8V7|||http://purl.uniprot.org/uniprot/G3S1I8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:CCSER2 ^@ http://purl.uniprot.org/uniprot/G3QKL0|||http://purl.uniprot.org/uniprot/G3S2Y5 ^@ Similarity ^@ Belongs to the CCSER family. http://togogenome.org/gene/9595:PDE4B ^@ http://purl.uniprot.org/uniprot/A0A2I2YS69|||http://purl.uniprot.org/uniprot/G3S4M8 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9595:FHIP1B ^@ http://purl.uniprot.org/uniprot/G3RIW5 ^@ Similarity ^@ Belongs to the FHIP family. http://togogenome.org/gene/9595:MRPS18A ^@ http://purl.uniprot.org/uniprot/G3SCE1 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9595:NOTO ^@ http://purl.uniprot.org/uniprot/G3RF60 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:IL1RL2 ^@ http://purl.uniprot.org/uniprot/G3QLE3 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9595:CORIN ^@ http://purl.uniprot.org/uniprot/G3R6C3 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:LECT2 ^@ http://purl.uniprot.org/uniprot/G3S367 ^@ Similarity ^@ Belongs to the LECT2/MIM-1 family. http://togogenome.org/gene/9595:MYO1G ^@ http://purl.uniprot.org/uniprot/G3R5P5 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9595:SERINC5 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z063 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9595:ELK4 ^@ http://purl.uniprot.org/uniprot/G3RX51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9595:HSPA14 ^@ http://purl.uniprot.org/uniprot/G3QPS5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 70 family.|||Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.|||Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.|||cytosol http://togogenome.org/gene/9595:CLN3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y7A6|||http://purl.uniprot.org/uniprot/A0A2I2YA61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the battenin family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9595:PCOLCE2 ^@ http://purl.uniprot.org/uniprot/G3QXX6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9595:TMEM131 ^@ http://purl.uniprot.org/uniprot/G3QGP6 ^@ Similarity ^@ Belongs to the TMEM131 family. http://togogenome.org/gene/9595:HOXA10 ^@ http://purl.uniprot.org/uniprot/A0A2I2YIN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9595:TCAF1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YSE4 ^@ Similarity ^@ Belongs to the TCAF family. http://togogenome.org/gene/9595:POPDC2 ^@ http://purl.uniprot.org/uniprot/G3QNZ3 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/9595:FXYD6 ^@ http://purl.uniprot.org/uniprot/G3QUD2 ^@ Similarity ^@ Belongs to the FXYD family. http://togogenome.org/gene/9595:PRORP ^@ http://purl.uniprot.org/uniprot/G3R970 ^@ Similarity ^@ Belongs to the PPR family. P subfamily. http://togogenome.org/gene/9595:MEF2D ^@ http://purl.uniprot.org/uniprot/A0A2I2ZB37|||http://purl.uniprot.org/uniprot/G3SH47 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:HYAL2 ^@ http://purl.uniprot.org/uniprot/G3QW01 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/9595:SLC4A8 ^@ http://purl.uniprot.org/uniprot/G3R9D5 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9595:HCRTR2 ^@ http://purl.uniprot.org/uniprot/G3SII0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:FEN1 ^@ http://purl.uniprot.org/uniprot/G3RA03 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Mitochondrion|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9595:LRRC42 ^@ http://purl.uniprot.org/uniprot/G3R555 ^@ Similarity ^@ Belongs to the LRRC42 family. http://togogenome.org/gene/9595:CBS ^@ http://purl.uniprot.org/uniprot/G3RQH5 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/9595:MAPK10 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZN14 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/9595:UFM1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YYE6|||http://purl.uniprot.org/uniprot/G3SHJ8 ^@ Function|||Similarity ^@ Belongs to the UFM1 family.|||Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. http://togogenome.org/gene/9595:XPO6 ^@ http://purl.uniprot.org/uniprot/G3QS71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:PEX5 ^@ http://purl.uniprot.org/uniprot/G3QL79 ^@ Similarity ^@ Belongs to the peroxisomal targeting signal receptor family. http://togogenome.org/gene/9595:FAM210B ^@ http://purl.uniprot.org/uniprot/A0A2I2ZUQ0 ^@ Similarity ^@ Belongs to the FAM210 family. http://togogenome.org/gene/9595:LOC101148218 ^@ http://purl.uniprot.org/uniprot/G3SHA6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:NUP58 ^@ http://purl.uniprot.org/uniprot/A0A2I2YV67|||http://purl.uniprot.org/uniprot/G3QM84 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/9595:PDE4C ^@ http://purl.uniprot.org/uniprot/A0A2I2ZKK2|||http://purl.uniprot.org/uniprot/A0A2I2ZN78 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9595:TAS2R60 ^@ http://purl.uniprot.org/uniprot/G3QLM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9595:LOC101138393 ^@ http://purl.uniprot.org/uniprot/G3SF23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:LOC101133937 ^@ http://purl.uniprot.org/uniprot/G3QE41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:LTA ^@ http://purl.uniprot.org/uniprot/G3QT71 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.|||Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. Interacts with TNFRSF14.|||Membrane|||Secreted http://togogenome.org/gene/9595:SLC9A4 ^@ http://purl.uniprot.org/uniprot/G3RF66 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Interacts with CHP1 and CHP2.|||Membrane http://togogenome.org/gene/9595:SLC25A1 ^@ http://purl.uniprot.org/uniprot/G3QTN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9595:LIPK ^@ http://purl.uniprot.org/uniprot/G3QKZ9 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9595:CLDN15 ^@ http://purl.uniprot.org/uniprot/G3SCY1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9595:ARSD ^@ http://purl.uniprot.org/uniprot/G3SAU8 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9595:LOC101127738 ^@ http://purl.uniprot.org/uniprot/G3RQ76 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9595:KIF18B ^@ http://purl.uniprot.org/uniprot/G3RB73|||http://purl.uniprot.org/uniprot/G3RZM8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9595:TMEM265 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZSA5 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9595:CDCA7 ^@ http://purl.uniprot.org/uniprot/G3QH14|||http://purl.uniprot.org/uniprot/G3S418 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9595:DPYSL2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y6Z9|||http://purl.uniprot.org/uniprot/G3QD81 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/9595:PHOSPHO2 ^@ http://purl.uniprot.org/uniprot/G3QTS4 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. PHOSPHO family. http://togogenome.org/gene/9595:AP1M1 ^@ http://purl.uniprot.org/uniprot/G3QNY3|||http://purl.uniprot.org/uniprot/G3SK90 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Golgi apparatus|||Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9595:ADAMTS5 ^@ http://purl.uniprot.org/uniprot/G3QVR6 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9595:STX17 ^@ http://purl.uniprot.org/uniprot/G3RAT0 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9595:WASF1 ^@ http://purl.uniprot.org/uniprot/G3QWL7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCAR/WAVE family.|||Binds actin and the Arp2/3 complex.|||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|||cytoskeleton http://togogenome.org/gene/9595:PIK3IP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZGG3|||http://purl.uniprot.org/uniprot/G3QR65 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:LYPLAL1 ^@ http://purl.uniprot.org/uniprot/G3QHC1 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/9595:PDGFRA ^@ http://purl.uniprot.org/uniprot/G3R4Z2 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.|||Membrane|||Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.|||Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. http://togogenome.org/gene/9595:TRABD2B ^@ http://purl.uniprot.org/uniprot/A0A2I2YYI1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TIKI family.|||Cell membrane|||Divalent metal cations. Mn(2+) or Co(2+).|||Membrane|||Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. http://togogenome.org/gene/9595:MTERF3 ^@ http://purl.uniprot.org/uniprot/G3R7B6 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/9595:RMI1 ^@ http://purl.uniprot.org/uniprot/G3RE68 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RMI1 family.|||Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.|||Nucleus http://togogenome.org/gene/9595:SLC25A52 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1D5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9595:TDGF1 ^@ http://purl.uniprot.org/uniprot/G3QLN2 ^@ Caution|||Similarity ^@ Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:CSNK1A1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZQU5|||http://purl.uniprot.org/uniprot/G3RDH8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:OCEL1 ^@ http://purl.uniprot.org/uniprot/G3R5W8 ^@ Similarity ^@ Belongs to the ELL/occludin family. http://togogenome.org/gene/9595:BANF1 ^@ http://purl.uniprot.org/uniprot/G3S5Z8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:DNAJC10 ^@ http://purl.uniprot.org/uniprot/G3R967 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9595:OXR1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YQR4|||http://purl.uniprot.org/uniprot/A0A2I2ZKZ2|||http://purl.uniprot.org/uniprot/G3QTR9 ^@ Similarity ^@ Belongs to the OXR1 family. http://togogenome.org/gene/9595:PTGER3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZEG4|||http://purl.uniprot.org/uniprot/A0A2I2ZTQ7|||http://purl.uniprot.org/uniprot/G3QE87 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:NPC2 ^@ http://purl.uniprot.org/uniprot/G3RAU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPC2 family.|||Secreted http://togogenome.org/gene/9595:KCNE5 ^@ http://purl.uniprot.org/uniprot/G3QZU7 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/9595:EEIG1 ^@ http://purl.uniprot.org/uniprot/G3RFH0 ^@ Similarity ^@ Belongs to the EEIG family. http://togogenome.org/gene/9595:APEX2 ^@ http://purl.uniprot.org/uniprot/G3QI28 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Cytoplasm|||Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.|||Mitochondrion|||Nucleus|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/9595:GNA12 ^@ http://purl.uniprot.org/uniprot/G3R227 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-alpha family. G(12) subfamily.|||Membrane http://togogenome.org/gene/9595:PTDSS1 ^@ http://purl.uniprot.org/uniprot/G3SCJ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphatidyl serine synthase family.|||Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:SOST ^@ http://purl.uniprot.org/uniprot/G3QKL9 ^@ Similarity ^@ Belongs to the sclerostin family. http://togogenome.org/gene/9595:LOC101153729 ^@ http://purl.uniprot.org/uniprot/G3QX37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lambda interferon family.|||Secreted http://togogenome.org/gene/9595:TBX10 ^@ http://purl.uniprot.org/uniprot/G3SF29 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9595:GPLD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YDH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GPLD1 family.|||Secreted http://togogenome.org/gene/9595:AMPD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YPD9 ^@ Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.|||Homotetramer. http://togogenome.org/gene/9595:GCNT2 ^@ http://purl.uniprot.org/uniprot/G3QQ11|||http://purl.uniprot.org/uniprot/G3S2G6 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:TLR3 ^@ http://purl.uniprot.org/uniprot/G3SGL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9595:FIP1L1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y6Z7|||http://purl.uniprot.org/uniprot/G3SBL8|||http://purl.uniprot.org/uniprot/G3SJN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FIP1 family.|||Nucleus http://togogenome.org/gene/9595:RPL24 ^@ http://purl.uniprot.org/uniprot/G3R7I4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/9595:KIFC1 ^@ http://purl.uniprot.org/uniprot/G3QDE3 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9595:UBE2D4 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZSM0 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9595:LOC101152944 ^@ http://purl.uniprot.org/uniprot/G3QS30 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/9595:FAR1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YI16 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acyl-CoA reductase family.|||Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.|||Peroxisome membrane http://togogenome.org/gene/9595:PSMA8 ^@ http://purl.uniprot.org/uniprot/G3RJT2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9595:BEX5 ^@ http://purl.uniprot.org/uniprot/G3SE44 ^@ Similarity ^@ Belongs to the BEX family. http://togogenome.org/gene/9595:FOXP1 ^@ http://purl.uniprot.org/uniprot/G3SIY1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SLC9C2 ^@ http://purl.uniprot.org/uniprot/G3R4F4 ^@ Similarity ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. http://togogenome.org/gene/9595:MRPS21 ^@ http://purl.uniprot.org/uniprot/G3S8Y8 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/9595:DCTN5 ^@ http://purl.uniprot.org/uniprot/G3RAP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.|||cytoskeleton http://togogenome.org/gene/9595:EML2 ^@ http://purl.uniprot.org/uniprot/G3RHI7|||http://purl.uniprot.org/uniprot/G3S867 ^@ Similarity ^@ Belongs to the WD repeat EMAP family. http://togogenome.org/gene/9595:RHCG ^@ http://purl.uniprot.org/uniprot/G3RHG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/9595:UGCG ^@ http://purl.uniprot.org/uniprot/G3S910 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/9595:ARAF ^@ http://purl.uniprot.org/uniprot/G3R027 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. http://togogenome.org/gene/9595:OXSR1 ^@ http://purl.uniprot.org/uniprot/G3QU09 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. http://togogenome.org/gene/9595:KIF3A ^@ http://purl.uniprot.org/uniprot/G3S0E8|||http://purl.uniprot.org/uniprot/G3SK66 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9595:ACRBP ^@ http://purl.uniprot.org/uniprot/G3RZK8 ^@ Subcellular Location Annotation ^@ acrosome http://togogenome.org/gene/9595:ZNF496 ^@ http://purl.uniprot.org/uniprot/G3RYY8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:IL12RB1 ^@ http://purl.uniprot.org/uniprot/G3QKI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/9595:LOC101130182 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZU56 ^@ Similarity ^@ Belongs to the cornifin (SPRR) family. http://togogenome.org/gene/9595:LOC101147167 ^@ http://purl.uniprot.org/uniprot/G3SG91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ATP6V1H ^@ http://purl.uniprot.org/uniprot/A0A2I2Z4M8|||http://purl.uniprot.org/uniprot/G3QE24 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase H subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9595:ACADL ^@ http://purl.uniprot.org/uniprot/G3QUJ6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acyl-CoA dehydrogenase family.|||Homotetramer.|||Mitochondrion matrix http://togogenome.org/gene/9595:LEAP2 ^@ http://purl.uniprot.org/uniprot/G3RTZ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LEAP2 family.|||Has an antimicrobial activity.|||Secreted http://togogenome.org/gene/9595:HMGA1 ^@ http://purl.uniprot.org/uniprot/G3SHP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGA family.|||Nucleus http://togogenome.org/gene/9595:BLM ^@ http://purl.uniprot.org/uniprot/G3QXK2 ^@ Similarity ^@ Belongs to the helicase family. RecQ subfamily. http://togogenome.org/gene/9595:CTPS1 ^@ http://purl.uniprot.org/uniprot/G3RLW2 ^@ Function|||Similarity ^@ Belongs to the CTP synthase family.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. http://togogenome.org/gene/9595:NGB ^@ http://purl.uniprot.org/uniprot/G3QTM7 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9595:CHRM5 ^@ http://purl.uniprot.org/uniprot/G3RNL2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. http://togogenome.org/gene/9595:EHD3 ^@ http://purl.uniprot.org/uniprot/G3QKK4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/9595:SCRIB ^@ http://purl.uniprot.org/uniprot/A0A2I2ZWD7|||http://purl.uniprot.org/uniprot/G3RNP1 ^@ Similarity ^@ Belongs to the LAP (LRR and PDZ) protein family. http://togogenome.org/gene/9595:MEF2B ^@ http://purl.uniprot.org/uniprot/G3SEK6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:DYSF ^@ http://purl.uniprot.org/uniprot/A0A2I2Y9X0|||http://purl.uniprot.org/uniprot/A0A2I2ZVY1|||http://purl.uniprot.org/uniprot/G3QWB2|||http://purl.uniprot.org/uniprot/G3S7Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ferlin family.|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/9595:LYN ^@ http://purl.uniprot.org/uniprot/G3R9U2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9595:MAGT1 ^@ http://purl.uniprot.org/uniprot/G3R499 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:CDKN1C ^@ http://purl.uniprot.org/uniprot/A0A2I2ZXY1|||http://purl.uniprot.org/uniprot/G3SEB2 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/9595:OTOP2 ^@ http://purl.uniprot.org/uniprot/G3QLB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the otopetrin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:LHFPL1 ^@ http://purl.uniprot.org/uniprot/G3R4A6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:APP ^@ http://purl.uniprot.org/uniprot/A0A2I2Y2N3|||http://purl.uniprot.org/uniprot/A0A2I2YBB2|||http://purl.uniprot.org/uniprot/G3QD87|||http://purl.uniprot.org/uniprot/G3S7J3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APP family.|||Cell membrane|||Cell surface|||Cytoplasmic vesicle|||Early endosome|||Endosome|||Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.|||Golgi apparatus|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).|||Nucleus|||Perikaryon|||Secreted|||The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.|||Vesicle|||clathrin-coated pit|||growth cone http://togogenome.org/gene/9595:ARTN ^@ http://purl.uniprot.org/uniprot/G3RJS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family. GDNF subfamily.|||Secreted http://togogenome.org/gene/9595:TRAPPC4 ^@ http://purl.uniprot.org/uniprot/G3QJK8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/9595:TOP3A ^@ http://purl.uniprot.org/uniprot/G3QKQ6 ^@ Function|||Similarity ^@ Belongs to the type IA topoisomerase family.|||Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. http://togogenome.org/gene/9595:EVC ^@ http://purl.uniprot.org/uniprot/G3RCZ5 ^@ Subcellular Location Annotation ^@ Membrane|||cilium basal body|||cilium membrane http://togogenome.org/gene/9595:DEFB1 ^@ http://purl.uniprot.org/uniprot/Q95M68 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta-defensin family.|||Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.|||Membrane|||Monomer. Homodimer.|||Secreted http://togogenome.org/gene/9595:TMEM138 ^@ http://purl.uniprot.org/uniprot/G3QN90 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM138 family.|||Membrane|||Required for ciliogenesis.|||Vacuole membrane|||cilium http://togogenome.org/gene/9595:PIH1D2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZHK0 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/9595:CPSF2 ^@ http://purl.uniprot.org/uniprot/G3R814 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.|||Nucleus http://togogenome.org/gene/9595:TNFRSF19 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZXF3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:PHF20L1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YQM9|||http://purl.uniprot.org/uniprot/A0A2I2ZRI2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:PPP1R3C ^@ http://purl.uniprot.org/uniprot/A0A2I2YWD3 ^@ Domain|||Function|||Subunit ^@ Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.|||Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.|||The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase. http://togogenome.org/gene/9595:BAG6 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZNR6|||http://purl.uniprot.org/uniprot/G3QS02|||http://purl.uniprot.org/uniprot/G3SDX2 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).|||cytosol|||extracellular exosome http://togogenome.org/gene/9595:LOC101129101 ^@ http://purl.uniprot.org/uniprot/G3QKI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ROPN1L ^@ http://purl.uniprot.org/uniprot/G3QQG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ropporin family.|||flagellum http://togogenome.org/gene/9595:LOC101128717 ^@ http://purl.uniprot.org/uniprot/G3QMJ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:WNT2 ^@ http://purl.uniprot.org/uniprot/Q2IBF4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).|||Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.|||Secreted|||extracellular matrix http://togogenome.org/gene/9595:MFAP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YJD5 ^@ Function|||Similarity ^@ Belongs to the MFAP1 family.|||Involved in pre-mRNA splicing as a component of the spliceosome. http://togogenome.org/gene/9595:WT1 ^@ http://purl.uniprot.org/uniprot/G3RQ97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Cytoplasm|||Nucleus speckle http://togogenome.org/gene/9595:GAST ^@ http://purl.uniprot.org/uniprot/G3RKF5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gastrin/cholecystokinin family.|||Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.|||Secreted http://togogenome.org/gene/9595:SLC7A5 ^@ http://purl.uniprot.org/uniprot/G3SJE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:FAM199X ^@ http://purl.uniprot.org/uniprot/G3RZE4 ^@ Similarity ^@ Belongs to the FAM199 family. http://togogenome.org/gene/9595:MON2 ^@ http://purl.uniprot.org/uniprot/G3R8U3|||http://purl.uniprot.org/uniprot/G3SEK7 ^@ Similarity ^@ Belongs to the MON2 family. http://togogenome.org/gene/9595:PPIL3 ^@ http://purl.uniprot.org/uniprot/G3SGD0 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9595:PKN1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y7S7|||http://purl.uniprot.org/uniprot/G3RIB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cleavage furrow|||Midbody|||Nucleus http://togogenome.org/gene/9595:UROS ^@ http://purl.uniprot.org/uniprot/G3R707 ^@ Similarity ^@ Belongs to the uroporphyrinogen-III synthase family. http://togogenome.org/gene/9595:LOC101141032 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZKH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:PSMD5 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y2G6 ^@ Similarity ^@ Belongs to the proteasome subunit S5B/HSM3 family. http://togogenome.org/gene/9595:LOC101143132 ^@ http://purl.uniprot.org/uniprot/G3QYB0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:GAL ^@ http://purl.uniprot.org/uniprot/G3QDD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the galanin family.|||Secreted http://togogenome.org/gene/9595:CPEB3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZU18 ^@ Similarity ^@ Belongs to the RRM CPEB family. http://togogenome.org/gene/9595:KIF16B ^@ http://purl.uniprot.org/uniprot/A0A2I2YQX1 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9595:PSMA6 ^@ http://purl.uniprot.org/uniprot/G3RBL9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9595:E2F5 ^@ http://purl.uniprot.org/uniprot/G3R2Q1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9595:PGM2L1 ^@ http://purl.uniprot.org/uniprot/G3QXX0 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/9595:CMTM1 ^@ http://purl.uniprot.org/uniprot/G3QNG6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:LOC101129979 ^@ http://purl.uniprot.org/uniprot/G3RQU6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:UROC1 ^@ http://purl.uniprot.org/uniprot/G3S3N4 ^@ Similarity ^@ Belongs to the urocanase family. http://togogenome.org/gene/9595:PKM ^@ http://purl.uniprot.org/uniprot/A0A2I2YRU7|||http://purl.uniprot.org/uniprot/G3QQT8|||http://purl.uniprot.org/uniprot/G3S8Q3 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/9595:SAMD4A ^@ http://purl.uniprot.org/uniprot/A0A2I2YXP4|||http://purl.uniprot.org/uniprot/G3QEG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMAUG family.|||Cytoplasm http://togogenome.org/gene/9595:LOC101126699 ^@ http://purl.uniprot.org/uniprot/G3RY77 ^@ Similarity ^@ Belongs to the glycine N-acyltransferase family. http://togogenome.org/gene/9595:CCR7 ^@ http://purl.uniprot.org/uniprot/G3RJP4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:RPL7L1 ^@ http://purl.uniprot.org/uniprot/G3S2G9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/9595:SNX1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YF74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome membrane|||Endosome membrane|||Membrane|||lamellipodium|||trans-Golgi network membrane http://togogenome.org/gene/9595:GPRC6A ^@ http://purl.uniprot.org/uniprot/G3QFV1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:SCAMP5 ^@ http://purl.uniprot.org/uniprot/G3SAX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/9595:TLE1 ^@ http://purl.uniprot.org/uniprot/G3QEP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat Groucho/TLE family.|||Nucleus http://togogenome.org/gene/9595:CD164L2 ^@ http://purl.uniprot.org/uniprot/G3RR38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD164 family.|||Membrane http://togogenome.org/gene/9595:MED10 ^@ http://purl.uniprot.org/uniprot/G3QKQ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 10 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9595:ATP6V0B ^@ http://purl.uniprot.org/uniprot/A0A2I2ZUX7|||http://purl.uniprot.org/uniprot/G3QM50 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9595:HTN1 ^@ http://purl.uniprot.org/uniprot/G3QQV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histatin/statherin family.|||Secreted http://togogenome.org/gene/9595:RELT ^@ http://purl.uniprot.org/uniprot/G3R437 ^@ Similarity ^@ Belongs to the RELT family. http://togogenome.org/gene/9595:SRP14 ^@ http://purl.uniprot.org/uniprot/G3R367 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SRP14 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.|||Cytoplasm|||Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. http://togogenome.org/gene/9595:NPBWR1 ^@ http://purl.uniprot.org/uniprot/G3RGV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:MAPK1 ^@ http://purl.uniprot.org/uniprot/G3R7J0 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.|||caveola|||focal adhesion http://togogenome.org/gene/9595:DEGS2 ^@ http://purl.uniprot.org/uniprot/G3QSW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:LOC101132260 ^@ http://purl.uniprot.org/uniprot/A0A2I2YFF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ACVR1 ^@ http://purl.uniprot.org/uniprot/G3QKB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9595:CDKN1B ^@ http://purl.uniprot.org/uniprot/G3SDA9 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/9595:NTNG1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1B1|||http://purl.uniprot.org/uniprot/A0A2I2ZTW9|||http://purl.uniprot.org/uniprot/A0A2I2ZWL1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:USP16 ^@ http://purl.uniprot.org/uniprot/A0A2I2YYF5 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C19 family. USP16 subfamily.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Homotetramer.|||Nucleus|||Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. Phosphorylation by AURKB enhances the deubiquitinase activity.|||Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.|||The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin. http://togogenome.org/gene/9595:AVPR1B ^@ http://purl.uniprot.org/uniprot/G3RB98 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane|||Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. http://togogenome.org/gene/9595:ESCO2 ^@ http://purl.uniprot.org/uniprot/G3R2L3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:BRF1 ^@ http://purl.uniprot.org/uniprot/G3QXB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIB family.|||Nucleus http://togogenome.org/gene/9595:SFMBT2 ^@ http://purl.uniprot.org/uniprot/G3QI80 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:HPS5 ^@ http://purl.uniprot.org/uniprot/G3RTU7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HPS5 family.|||Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.|||May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.|||cytosol http://togogenome.org/gene/9595:TAF7L ^@ http://purl.uniprot.org/uniprot/G3QP91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF7 family.|||Nucleus http://togogenome.org/gene/9595:PERP ^@ http://purl.uniprot.org/uniprot/A0A2I2Y8U4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/9595:DDX49 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZVB8 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9595:STAT6 ^@ http://purl.uniprot.org/uniprot/G3QGF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:LOC101150282 ^@ http://purl.uniprot.org/uniprot/G3SCE6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:PIGW ^@ http://purl.uniprot.org/uniprot/G3QY46 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGW family.|||Endoplasmic reticulum membrane|||Membrane|||Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. http://togogenome.org/gene/9595:BLOC1S6 ^@ http://purl.uniprot.org/uniprot/G3RDE4 ^@ Function|||Similarity ^@ Belongs to the BLOC1S6 family.|||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process. http://togogenome.org/gene/9595:TERF2IP ^@ http://purl.uniprot.org/uniprot/G3SE84 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.|||Belongs to the RAP1 family.|||Homodimer.|||Nucleus|||telomere http://togogenome.org/gene/9595:POMK ^@ http://purl.uniprot.org/uniprot/G3RLH7 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif. http://togogenome.org/gene/9595:IFI27L1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YU41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFI6/IFI27 family.|||Membrane http://togogenome.org/gene/9595:MPI ^@ http://purl.uniprot.org/uniprot/A0A2I2Z5A4|||http://purl.uniprot.org/uniprot/G3RFM0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the mannose-6-phosphate isomerase type 1 family.|||Binds 1 zinc ion per subunit.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/9595:AP4B1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YYV2|||http://purl.uniprot.org/uniprot/G3R6Z0 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/9595:ARMT1 ^@ http://purl.uniprot.org/uniprot/G3S2Y4 ^@ Domain|||Function|||Similarity ^@ Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.|||Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.|||Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine. http://togogenome.org/gene/9595:RRAGA ^@ http://purl.uniprot.org/uniprot/G3S7I4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/9595:NODAL ^@ http://purl.uniprot.org/uniprot/G3QJE8 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9595:GAL3ST1 ^@ http://purl.uniprot.org/uniprot/G3R2Y3 ^@ Similarity ^@ Belongs to the galactose-3-O-sulfotransferase family. http://togogenome.org/gene/9595:LOC101129229 ^@ http://purl.uniprot.org/uniprot/G3S988 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:ST3GAL2 ^@ http://purl.uniprot.org/uniprot/G3R0D9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9595:SPAM1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZU03|||http://purl.uniprot.org/uniprot/G3QVL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 56 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ADAM23 ^@ http://purl.uniprot.org/uniprot/A0A2I2YGG8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:LOC101150759 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZAL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:PI4K2B ^@ http://purl.uniprot.org/uniprot/G3RDX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.|||Membrane http://togogenome.org/gene/9595:LOC101153683 ^@ http://purl.uniprot.org/uniprot/G3RSY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:CEP19 ^@ http://purl.uniprot.org/uniprot/G3S8D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP19 family.|||centriole|||cilium basal body|||spindle pole http://togogenome.org/gene/9595:SPESP1 ^@ http://purl.uniprot.org/uniprot/G3RCT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPESP1 family.|||Involved in fertilization ability of sperm.|||acrosome http://togogenome.org/gene/9595:PNP ^@ http://purl.uniprot.org/uniprot/G3SH63 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family.|||Homotrimer.|||The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. http://togogenome.org/gene/9595:TNFRSF25 ^@ http://purl.uniprot.org/uniprot/A0A2I2YXM2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:E2F7 ^@ http://purl.uniprot.org/uniprot/G3RA82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9595:TAS2R40 ^@ http://purl.uniprot.org/uniprot/G3RK90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9595:SLC35B3 ^@ http://purl.uniprot.org/uniprot/G3R794 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/9595:ACADS ^@ http://purl.uniprot.org/uniprot/A0A2I2Z339|||http://purl.uniprot.org/uniprot/G3QI49 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9595:TSPO2 ^@ http://purl.uniprot.org/uniprot/G3R8R5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TspO/BZRP family.|||Membrane http://togogenome.org/gene/9595:MDK ^@ http://purl.uniprot.org/uniprot/G3S2W7 ^@ Similarity ^@ Belongs to the pleiotrophin family. http://togogenome.org/gene/9595:MAPK8 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZC90|||http://purl.uniprot.org/uniprot/A0A2I2ZPX0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/9595:REN ^@ http://purl.uniprot.org/uniprot/G3SCD8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A1 family.|||Interacts with ATP6AP2.|||Membrane|||Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. http://togogenome.org/gene/9595:MAPKAP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y7P7|||http://purl.uniprot.org/uniprot/A0A2I2YV76|||http://purl.uniprot.org/uniprot/G3QT17|||http://purl.uniprot.org/uniprot/G3RMW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SIN1 family.|||Cytoplasmic vesicle http://togogenome.org/gene/9595:YIPF5 ^@ http://purl.uniprot.org/uniprot/G3RZC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane http://togogenome.org/gene/9595:TNFRSF10A ^@ http://purl.uniprot.org/uniprot/A0A2I2ZI00 ^@ Caution|||Function ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. http://togogenome.org/gene/9595:TLE6 ^@ http://purl.uniprot.org/uniprot/G3RFN3 ^@ Similarity ^@ Belongs to the WD repeat Groucho/TLE family. http://togogenome.org/gene/9595:MCUR1 ^@ http://purl.uniprot.org/uniprot/G3QJJ7 ^@ Similarity ^@ Belongs to the CCDC90 family. http://togogenome.org/gene/9595:POGLUT2 ^@ http://purl.uniprot.org/uniprot/G3R624 ^@ Similarity ^@ Belongs to the KDELC family. http://togogenome.org/gene/9595:MOGAT1 ^@ http://purl.uniprot.org/uniprot/G3R0J0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9595:CKAP2L ^@ http://purl.uniprot.org/uniprot/G3SK27 ^@ Similarity ^@ Belongs to the CKAP2 family. http://togogenome.org/gene/9595:LYRM2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZJ23 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9595:PSMB11 ^@ http://purl.uniprot.org/uniprot/G3QWR8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:GCLC ^@ http://purl.uniprot.org/uniprot/G3QV17 ^@ Similarity ^@ Belongs to the glutamate--cysteine ligase type 3 family. http://togogenome.org/gene/9595:SERPINA3 ^@ http://purl.uniprot.org/uniprot/G3QEH5 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9595:CXCL5 ^@ http://purl.uniprot.org/uniprot/G3SIZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9595:ZSCAN30 ^@ http://purl.uniprot.org/uniprot/G3RWS5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SLC39A14 ^@ http://purl.uniprot.org/uniprot/A0A2I2YLD7|||http://purl.uniprot.org/uniprot/G3QMF7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:EDC3 ^@ http://purl.uniprot.org/uniprot/G3QLW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EDC3 family.|||P-body http://togogenome.org/gene/9595:TMEM214 ^@ http://purl.uniprot.org/uniprot/G3RL76 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TMEM214 family.|||Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.|||Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:HUWE1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZC49 ^@ Similarity ^@ Belongs to the UPL family. TOM1/PTR1 subfamily. http://togogenome.org/gene/9595:VAMP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z5Z0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9595:TMEM132A ^@ http://purl.uniprot.org/uniprot/G3QZZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM132 family.|||Membrane http://togogenome.org/gene/9595:ARSI ^@ http://purl.uniprot.org/uniprot/G3SBP0 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9595:LOC101148899 ^@ http://purl.uniprot.org/uniprot/G3QSU3 ^@ Similarity ^@ Belongs to the cytochrome c oxidase VIIa family. http://togogenome.org/gene/9595:SFXN5 ^@ http://purl.uniprot.org/uniprot/G3QRA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9595:ATOSB ^@ http://purl.uniprot.org/uniprot/G3QL21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATOS family.|||Nucleus http://togogenome.org/gene/9595:CD5L ^@ http://purl.uniprot.org/uniprot/G3R058 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:IFT43 ^@ http://purl.uniprot.org/uniprot/G3QGK5 ^@ Similarity ^@ Belongs to the IFT43 family. http://togogenome.org/gene/9595:RWDD3 ^@ http://purl.uniprot.org/uniprot/G3RYE8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9595:SIVA1 ^@ http://purl.uniprot.org/uniprot/G3RB25 ^@ Function|||PTM|||Subcellular Location Annotation ^@ Cytoplasm|||Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.|||Nucleus|||Phosphorylated by ABL2/ARG in response to oxidative stress. http://togogenome.org/gene/9595:IFT56 ^@ http://purl.uniprot.org/uniprot/G3QSE7 ^@ Similarity ^@ Belongs to the IFT56 family. http://togogenome.org/gene/9595:GRIA1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YPI9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9595:ATG4C ^@ http://purl.uniprot.org/uniprot/G3QWE3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/9595:RPS27A ^@ http://purl.uniprot.org/uniprot/G3RVB1 ^@ Similarity ^@ In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.|||In the N-terminal section; belongs to the ubiquitin family. http://togogenome.org/gene/9595:CD46 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y6M3|||http://purl.uniprot.org/uniprot/G3QD59|||http://purl.uniprot.org/uniprot/G3RSH3|||http://purl.uniprot.org/uniprot/G3SGB2 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||acrosome inner membrane http://togogenome.org/gene/9595:PTS ^@ http://purl.uniprot.org/uniprot/A0A2I2YV86 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the PTPS family.|||Binds 1 zinc ion per subunit.|||Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. http://togogenome.org/gene/9595:RPS19BP1 ^@ http://purl.uniprot.org/uniprot/G3R3P3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AROS family.|||nucleolus http://togogenome.org/gene/9595:LOC101151556 ^@ http://purl.uniprot.org/uniprot/G3R5Y1 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9595:NADK ^@ http://purl.uniprot.org/uniprot/G3RQZ2 ^@ Similarity ^@ Belongs to the NAD kinase family. http://togogenome.org/gene/9595:MOGS ^@ http://purl.uniprot.org/uniprot/A0A2I2YD12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 63 family.|||Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9595:LOC101150151 ^@ http://purl.uniprot.org/uniprot/G3RDP1 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9595:PARP16 ^@ http://purl.uniprot.org/uniprot/G3SBT9 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9595:ZNF18 ^@ http://purl.uniprot.org/uniprot/G3QRQ6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:TRMT1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZR82|||http://purl.uniprot.org/uniprot/G3RDQ8 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. http://togogenome.org/gene/9595:LOC101124572 ^@ http://purl.uniprot.org/uniprot/G3S063 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9595:CETN2 ^@ http://purl.uniprot.org/uniprot/G3R6X2 ^@ Similarity ^@ Belongs to the centrin family. http://togogenome.org/gene/9595:CCL1 ^@ http://purl.uniprot.org/uniprot/G3RRC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9595:HNRNPR ^@ http://purl.uniprot.org/uniprot/G3SIJ9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:SLC35C2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZAS0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:LOC101141395 ^@ http://purl.uniprot.org/uniprot/G3QFY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MHC class I family.|||Belongs to the MHC class II family.|||Endosome membrane|||Lysosome membrane http://togogenome.org/gene/9595:ATG13 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z9M8|||http://purl.uniprot.org/uniprot/G3QSD9|||http://purl.uniprot.org/uniprot/G3RZC2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.|||Belongs to the ATG13 family. Metazoan subfamily.|||Preautophagosomal structure http://togogenome.org/gene/9595:PCSK1 ^@ http://purl.uniprot.org/uniprot/G3QVR2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S8 family.|||Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.|||Vesicle|||secretory vesicle http://togogenome.org/gene/9595:A2M ^@ http://purl.uniprot.org/uniprot/G3RD11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.|||Secreted http://togogenome.org/gene/9595:ATXN1 ^@ http://purl.uniprot.org/uniprot/G3QNH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATXN1 family.|||Nucleus http://togogenome.org/gene/9595:PKD2L2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YNR7|||http://purl.uniprot.org/uniprot/G3R4D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the polycystin family.|||Membrane http://togogenome.org/gene/9595:SLC40A1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZHV5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lateral cell membrane|||May be involved in iron transport and iron homeostasis.|||Membrane http://togogenome.org/gene/9595:AADACL2 ^@ http://purl.uniprot.org/uniprot/G3R0M5 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/9595:LOC101136913 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZB54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:SLC35B1 ^@ http://purl.uniprot.org/uniprot/G3RQ62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/9595:PGAP3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YFK6|||http://purl.uniprot.org/uniprot/A0A2I2ZIR1|||http://purl.uniprot.org/uniprot/G3SAB8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PGAP3 family.|||Golgi apparatus membrane|||Involved in the lipid remodeling steps of GPI-anchor maturation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:LOC101132414 ^@ http://purl.uniprot.org/uniprot/G3RXM3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9595:EIF4E1B ^@ http://purl.uniprot.org/uniprot/G3RMR3 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/9595:PRSS16 ^@ http://purl.uniprot.org/uniprot/G3R2M8 ^@ Similarity ^@ Belongs to the peptidase S28 family. http://togogenome.org/gene/9595:SPACA5 ^@ http://purl.uniprot.org/uniprot/G3SBU4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9595:USP7 ^@ http://purl.uniprot.org/uniprot/G3QRK0 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/9595:LOC101152957 ^@ http://purl.uniprot.org/uniprot/G3QD82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:SLC27A3 ^@ http://purl.uniprot.org/uniprot/G3QMP1 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9595:KRT23 ^@ http://purl.uniprot.org/uniprot/G3RNV9 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:PRNP ^@ http://purl.uniprot.org/uniprot/P40252 ^@ Disease Annotation|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prion family.|||Cell membrane|||Contains an N-terminal region composed of octamer repeats. At low copper concentrations, the sidechains of His residues from three or four repeats contribute to the binding of a single copper ion. Alternatively, a copper ion can be bound by interaction with the sidechain and backbone amide nitrogen of a single His residue. The observed copper binding stoichiometry suggests that two repeat regions cooperate to stabilize the binding of a single copper ion. At higher copper concentrations, each octamer can bind one copper ion by interactions with the His sidechain and Gly backbone atoms. A mixture of binding types may occur, especially in the case of octamer repeat expansion. Copper binding may stabilize the conformation of this region and may promote oligomerization.|||Golgi apparatus|||Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).|||Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization. Interacts with GRB2, APP, ERI3/PRNPIP and SYN1 (By similarity). Mislocalized cytosolically exposed PrP interacts with MGRN1; this interaction alters MGRN1 subcellular location and causes lysosomal enlargement (By similarity). Interacts with APP. Interacts with KIAA1191 (By similarity). Interacts with ADGRG6 (By similarity).|||PrP is found in high quantity in the brain of humans and animals infected with the degenerative neurological diseases kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.|||The normal, monomeric form has a mainly alpha-helical structure. The disease-associated, protease-resistant form forms amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Disease mutations may favor intermolecular contacts via short beta strands, and may thereby trigger oligomerization. http://togogenome.org/gene/9595:MARCKSL1 ^@ http://purl.uniprot.org/uniprot/G3R7W1 ^@ Similarity ^@ Belongs to the MARCKS family. http://togogenome.org/gene/9595:CBX7 ^@ http://purl.uniprot.org/uniprot/G3QQA9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:FAM114A2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YE12 ^@ Similarity ^@ Belongs to the FAM114 family. http://togogenome.org/gene/9595:TMEM19 ^@ http://purl.uniprot.org/uniprot/G3RXQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM19 family.|||Membrane http://togogenome.org/gene/9595:MRGPRX4 ^@ http://purl.uniprot.org/uniprot/G3RK72 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:STEAP3 ^@ http://purl.uniprot.org/uniprot/G3R8X8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9595:RPLP0 ^@ http://purl.uniprot.org/uniprot/G3SDP0 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL10 family.|||Ribosomal protein P0 is the functional equivalent of E.coli protein L10. http://togogenome.org/gene/9595:WDR44 ^@ http://purl.uniprot.org/uniprot/G3QL01 ^@ Subcellular Location Annotation ^@ trans-Golgi network http://togogenome.org/gene/9595:LYZL2 ^@ http://purl.uniprot.org/uniprot/G3SCD7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9595:MYH3 ^@ http://purl.uniprot.org/uniprot/G3QE77 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9595:NEU4 ^@ http://purl.uniprot.org/uniprot/G3REG3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/9595:SLC47A1 ^@ http://purl.uniprot.org/uniprot/G3S2U3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.|||Membrane http://togogenome.org/gene/9595:PCNA ^@ http://purl.uniprot.org/uniprot/G3QH49 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PCNA family.|||Nucleus|||This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. http://togogenome.org/gene/9595:SPTLC2 ^@ http://purl.uniprot.org/uniprot/G3R898 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9595:CCDC93 ^@ http://purl.uniprot.org/uniprot/G3SJF9 ^@ Similarity ^@ Belongs to the CCDC93 family. http://togogenome.org/gene/9595:LOC101126623 ^@ http://purl.uniprot.org/uniprot/G3RI90 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9595:PSMB6 ^@ http://purl.uniprot.org/uniprot/G3R756 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:TMLHE ^@ http://purl.uniprot.org/uniprot/G3S446 ^@ Similarity ^@ Belongs to the gamma-BBH/TMLD family. http://togogenome.org/gene/9595:TH ^@ http://purl.uniprot.org/uniprot/G3QN04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.|||axon|||perinuclear region|||synaptic vesicle http://togogenome.org/gene/9595:TMEM178B ^@ http://purl.uniprot.org/uniprot/A0A2I2Z5R3 ^@ Similarity ^@ Belongs to the TMEM178 family. http://togogenome.org/gene/9595:HARS2 ^@ http://purl.uniprot.org/uniprot/G3RBJ9 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9595:RRAGB ^@ http://purl.uniprot.org/uniprot/G3R786|||http://purl.uniprot.org/uniprot/G3S8V8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/9595:PHETA2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YH37 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sesquipedalian family.|||Early endosome|||Forms homodimers and heterodimers with PHETA. Interacts with OCRL and INPP5B.|||Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.|||Recycling endosome|||clathrin-coated vesicle|||trans-Golgi network http://togogenome.org/gene/9595:IGF2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YR49|||http://purl.uniprot.org/uniprot/A0A2I2ZL48 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.|||Secreted http://togogenome.org/gene/9595:YIPF1 ^@ http://purl.uniprot.org/uniprot/G3RHA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Endosome membrane|||Golgi apparatus membrane|||Late endosome membrane|||Membrane|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/9595:SBF1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZMY5 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9595:TM4SF5 ^@ http://purl.uniprot.org/uniprot/G3R744 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9595:ERO1A ^@ http://purl.uniprot.org/uniprot/G3RTY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EROs family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9595:A4GNT ^@ http://purl.uniprot.org/uniprot/G3QPH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 32 family.|||Golgi apparatus membrane http://togogenome.org/gene/9595:LOC101134050 ^@ http://purl.uniprot.org/uniprot/G3S9C0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:VANGL2 ^@ http://purl.uniprot.org/uniprot/G3RDQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Vang family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:HABP4 ^@ http://purl.uniprot.org/uniprot/G3R9D8 ^@ Similarity ^@ Belongs to the SERBP1-HABP4 family. http://togogenome.org/gene/9595:ME2 ^@ http://purl.uniprot.org/uniprot/G3R5I4 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/9595:CPA3 ^@ http://purl.uniprot.org/uniprot/G3S533 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9595:ELOVL5 ^@ http://purl.uniprot.org/uniprot/G3R6X9|||http://purl.uniprot.org/uniprot/G3S6X0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Belongs to the ELO family. ELOVL5 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Membrane|||dendrite http://togogenome.org/gene/9595:MYORG ^@ http://purl.uniprot.org/uniprot/G3QXJ4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/9595:SF3B5 ^@ http://purl.uniprot.org/uniprot/G3QGQ5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SF3B5 family.|||Component of the spliceosome B complex.|||Nucleus http://togogenome.org/gene/9595:LDHAL6A ^@ http://purl.uniprot.org/uniprot/A0A2I2Z7D8 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/9595:FAM110D ^@ http://purl.uniprot.org/uniprot/G3QUM4 ^@ Similarity ^@ Belongs to the FAM110 family. http://togogenome.org/gene/9595:CPVL ^@ http://purl.uniprot.org/uniprot/G3R230 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/9595:TMBIM4 ^@ http://purl.uniprot.org/uniprot/A0A2I2YGH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9595:FADS1 ^@ http://purl.uniprot.org/uniprot/G3RA11 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:IRF7 ^@ http://purl.uniprot.org/uniprot/G3S813 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:TMEM256 ^@ http://purl.uniprot.org/uniprot/G3QD08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM256 family.|||Membrane http://togogenome.org/gene/9595:ITGA6 ^@ http://purl.uniprot.org/uniprot/G3QXU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9595:ENTPD6 ^@ http://purl.uniprot.org/uniprot/G3RG09 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9595:AATF ^@ http://purl.uniprot.org/uniprot/G3SD86 ^@ Similarity ^@ Belongs to the AATF family. http://togogenome.org/gene/9595:JAGN1 ^@ http://purl.uniprot.org/uniprot/G3R3V7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the jagunal family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:IP6K1 ^@ http://purl.uniprot.org/uniprot/G3R503 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9595:MFN1 ^@ http://purl.uniprot.org/uniprot/G3R1R7 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9595:NUP98 ^@ http://purl.uniprot.org/uniprot/G3SH93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin GLFG family.|||Nucleus membrane|||nuclear pore complex http://togogenome.org/gene/9595:BABAM1 ^@ http://purl.uniprot.org/uniprot/G3QSM0|||http://purl.uniprot.org/uniprot/G3S649 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BABAM1 family.|||Nucleus http://togogenome.org/gene/9595:MSMP ^@ http://purl.uniprot.org/uniprot/G3QWQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-microseminoprotein family.|||Secreted http://togogenome.org/gene/9595:TMED5 ^@ http://purl.uniprot.org/uniprot/G3RJ42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9595:HRH4 ^@ http://purl.uniprot.org/uniprot/G3QS38 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:CHMP5 ^@ http://purl.uniprot.org/uniprot/G3RK77 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9595:ADAMTS14 ^@ http://purl.uniprot.org/uniprot/G3R9J1 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9595:DOP1B ^@ http://purl.uniprot.org/uniprot/G3QMJ6 ^@ Similarity ^@ Belongs to the dopey family. http://togogenome.org/gene/9595:GUK1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YN43|||http://purl.uniprot.org/uniprot/G3RCK1|||http://purl.uniprot.org/uniprot/G3S7U3 ^@ Similarity ^@ Belongs to the guanylate kinase family. http://togogenome.org/gene/9595:CHD6 ^@ http://purl.uniprot.org/uniprot/G3RBG1 ^@ Similarity ^@ Belongs to the SNF2/RAD54 helicase family. http://togogenome.org/gene/9595:AMOT ^@ http://purl.uniprot.org/uniprot/G3R6B8 ^@ Similarity ^@ Belongs to the angiomotin family. http://togogenome.org/gene/9595:MTAP ^@ http://purl.uniprot.org/uniprot/A0A2I2ZHX6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.|||Cytoplasm|||Homotrimer.|||Nucleus http://togogenome.org/gene/9595:NUDT19 ^@ http://purl.uniprot.org/uniprot/G3QXQ6 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/9595:RPL26 ^@ http://purl.uniprot.org/uniprot/G3RMT1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/9595:TGM5 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZV85|||http://purl.uniprot.org/uniprot/G3QUL1 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9595:POU2F2 ^@ http://purl.uniprot.org/uniprot/G3R671 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-2 subfamily.|||Nucleus|||Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. http://togogenome.org/gene/9595:COPB1 ^@ http://purl.uniprot.org/uniprot/G3S1L5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ COPI-coated vesicle membrane|||Cytoplasm|||Endoplasmic reticulum-Golgi intermediate compartment|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/9595:CNTNAP1 ^@ http://purl.uniprot.org/uniprot/G3QLG1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||paranodal septate junction http://togogenome.org/gene/9595:PRRX2 ^@ http://purl.uniprot.org/uniprot/G3QE99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/9595:LOC101126994 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZRN8|||http://purl.uniprot.org/uniprot/G3QVP9 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9595:DMRTB1 ^@ http://purl.uniprot.org/uniprot/G3S787 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/9595:ALG5 ^@ http://purl.uniprot.org/uniprot/G3QKR3 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/9595:PLA2G15 ^@ http://purl.uniprot.org/uniprot/G3QGS4 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9595:STOM ^@ http://purl.uniprot.org/uniprot/A0A2I2ZIH3 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/9595:LOC101136730 ^@ http://purl.uniprot.org/uniprot/G3QFS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:HTN3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YBS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histatin/statherin family.|||Secreted http://togogenome.org/gene/9595:PTGFR ^@ http://purl.uniprot.org/uniprot/G3REY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:PRDM5 ^@ http://purl.uniprot.org/uniprot/A0A2I2YGF8|||http://purl.uniprot.org/uniprot/A0A2I2ZNF0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:YPEL3 ^@ http://purl.uniprot.org/uniprot/G3RAX9 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9595:NRN1 ^@ http://purl.uniprot.org/uniprot/G3QR76 ^@ Similarity ^@ Belongs to the neuritin family. http://togogenome.org/gene/9595:MLH1 ^@ http://purl.uniprot.org/uniprot/G3RJQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||Nucleus http://togogenome.org/gene/9595:CCT3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z9P3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9595:UBA5 ^@ http://purl.uniprot.org/uniprot/G3QTF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.|||Endoplasmic reticulum membrane|||Golgi apparatus http://togogenome.org/gene/9595:CFHR5 ^@ http://purl.uniprot.org/uniprot/G3QJ14 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:SLC10A4 ^@ http://purl.uniprot.org/uniprot/G3QXD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/9595:ATP2A2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YDK6|||http://purl.uniprot.org/uniprot/A0A2I2YIY1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/9595:KCNQ5 ^@ http://purl.uniprot.org/uniprot/G3SGQ6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:LOC109024875 ^@ http://purl.uniprot.org/uniprot/G3S0J7 ^@ Function|||Subunit ^@ In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9595:TRIM2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YQC4 ^@ Similarity ^@ Belongs to the TRIM/RBCC family. http://togogenome.org/gene/9595:SEPTIN2 ^@ http://purl.uniprot.org/uniprot/G3QPK8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cleavage furrow|||Filament-forming cytoskeletal GTPase.|||Midbody|||Septins polymerize into heterooligomeric protein complexes that form filaments.|||cilium membrane|||flagellum|||spindle http://togogenome.org/gene/9595:SUOX ^@ http://purl.uniprot.org/uniprot/G3RXF0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids.|||Homodimer.|||Mitochondrion intermembrane space http://togogenome.org/gene/9595:FXYD4 ^@ http://purl.uniprot.org/uniprot/G3R5L8 ^@ Similarity ^@ Belongs to the FXYD family. http://togogenome.org/gene/9595:CASP14 ^@ http://purl.uniprot.org/uniprot/G3QDU6 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9595:CDKL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZYD1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:NCOA1 ^@ http://purl.uniprot.org/uniprot/G3R6P2|||http://purl.uniprot.org/uniprot/G3RV45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRC/p160 nuclear receptor coactivator family.|||Nucleus http://togogenome.org/gene/9595:CLEC12B ^@ http://purl.uniprot.org/uniprot/G3R0F9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:CENPC ^@ http://purl.uniprot.org/uniprot/G3R2W2 ^@ Similarity ^@ Belongs to the CENP-C/MIF2 family. http://togogenome.org/gene/9595:ANPEP ^@ http://purl.uniprot.org/uniprot/G3QSE0 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9595:SLC27A6 ^@ http://purl.uniprot.org/uniprot/G3RXT6 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9595:AMDHD2 ^@ http://purl.uniprot.org/uniprot/G3RW11 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. NagA family.|||Binds 1 divalent metal cation per subunit.|||Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. http://togogenome.org/gene/9595:STX12 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZJA2 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9595:MASP2 ^@ http://purl.uniprot.org/uniprot/G3RH68|||http://purl.uniprot.org/uniprot/G3RUG1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:CDC42 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z2P0|||http://purl.uniprot.org/uniprot/A0A2I2Z7E7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.|||Cell membrane|||Membrane|||Midbody|||Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. http://togogenome.org/gene/9595:RPL9 ^@ http://purl.uniprot.org/uniprot/G3SHM1 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/9595:GRP ^@ http://purl.uniprot.org/uniprot/G3QJM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bombesin/neuromedin-B/ranatensin family.|||Secreted|||neuron projection http://togogenome.org/gene/9595:CNNM2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z6D9|||http://purl.uniprot.org/uniprot/G3RBR6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ACDP family.|||Cell membrane|||Membrane|||Metal transporter. http://togogenome.org/gene/9595:ZSCAN18 ^@ http://purl.uniprot.org/uniprot/G3RYM1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:PPP1R1B ^@ http://purl.uniprot.org/uniprot/G3QV38 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 1 family. http://togogenome.org/gene/9595:RRH ^@ http://purl.uniprot.org/uniprot/G3RNE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9595:B4GALT1 ^@ http://purl.uniprot.org/uniprot/G3R175 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9595:SV2A ^@ http://purl.uniprot.org/uniprot/G3QKD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/9595:ANP32B ^@ http://purl.uniprot.org/uniprot/G3R7K6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANP32 family.|||Multifunctional protein that is involved in the regulation of many processes.|||Nucleus http://togogenome.org/gene/9595:GLIS1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z8D6 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/9595:CNN1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y792 ^@ Function|||Similarity ^@ Belongs to the calponin family.|||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. http://togogenome.org/gene/9595:LOC101129227 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZQQ5 ^@ Similarity ^@ Belongs to the cornifin (SPRR) family. http://togogenome.org/gene/9595:CSTF2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZTJ9|||http://purl.uniprot.org/uniprot/G3RRQ9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:CCNA2 ^@ http://purl.uniprot.org/uniprot/G3QIC8 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin AB subfamily. http://togogenome.org/gene/9595:LOC101142537 ^@ http://purl.uniprot.org/uniprot/G3RSZ1 ^@ Similarity ^@ Belongs to the SSX family. http://togogenome.org/gene/9595:BCAN ^@ http://purl.uniprot.org/uniprot/G3S2H7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aggrecan/versican proteoglycan family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9595:HYAL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZQS0|||http://purl.uniprot.org/uniprot/G3QVZ5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/9595:IRX5 ^@ http://purl.uniprot.org/uniprot/G3S1Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/IRO homeobox family.|||Nucleus http://togogenome.org/gene/9595:PES1 ^@ http://purl.uniprot.org/uniprot/G3QZN0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pescadillo family.|||Chromosome|||Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome. Interacts with IRS1 and UBTF. May interact with MAP1B.|||Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.|||Sumoylated.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9595:GSTM4 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z385 ^@ Similarity|||Subunit ^@ Belongs to the GST superfamily. Mu family.|||Homodimer. http://togogenome.org/gene/9595:ECH1 ^@ http://purl.uniprot.org/uniprot/G3QLW6 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9595:PSMA7 ^@ http://purl.uniprot.org/uniprot/G3QS87 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9595:STAG2 ^@ http://purl.uniprot.org/uniprot/G3QND0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||centromere http://togogenome.org/gene/9595:ACSL5 ^@ http://purl.uniprot.org/uniprot/G3QPL4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion outer membrane http://togogenome.org/gene/9595:CCNDBP1 ^@ http://purl.uniprot.org/uniprot/G3SIP2 ^@ Similarity|||Subunit ^@ Belongs to the CCNDBP1 family.|||Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3. http://togogenome.org/gene/9595:ABRAXAS1 ^@ http://purl.uniprot.org/uniprot/G3QSQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM175 family. Abraxas subfamily.|||Nucleus http://togogenome.org/gene/9595:DZIP1L ^@ http://purl.uniprot.org/uniprot/G3R7B2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DZIP C2H2-type zinc-finger protein family.|||cilium basal body http://togogenome.org/gene/9595:DNAJB14 ^@ http://purl.uniprot.org/uniprot/G3QD47 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:CLIC5 ^@ http://purl.uniprot.org/uniprot/G3SBW3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/9595:DXO ^@ http://purl.uniprot.org/uniprot/G3QIM6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DXO/Dom3Z family.|||Binds 2 magnesium ions.|||Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.|||Nucleus http://togogenome.org/gene/9595:RRP15 ^@ http://purl.uniprot.org/uniprot/G3RKD0 ^@ Similarity ^@ Belongs to the RRP15 family. http://togogenome.org/gene/9595:LOC101126416 ^@ http://purl.uniprot.org/uniprot/G3SCM0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9595:RNPEP ^@ http://purl.uniprot.org/uniprot/G3RE55 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9595:ZNF706 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z9V7 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9595:CASP7 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZD95 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9595:TPPP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YJM1 ^@ Similarity ^@ Belongs to the TPPP family. http://togogenome.org/gene/9595:GJA10 ^@ http://purl.uniprot.org/uniprot/G3RDV7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9595:NDST3 ^@ http://purl.uniprot.org/uniprot/G3SKG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/9595:ANKRD34C ^@ http://purl.uniprot.org/uniprot/A0A2I2ZI35 ^@ Similarity ^@ Belongs to the ANKRD34 family. http://togogenome.org/gene/9595:DBNDD2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z6B0 ^@ Similarity ^@ Belongs to the dysbindin family. http://togogenome.org/gene/9595:MB ^@ http://purl.uniprot.org/uniprot/G3R764 ^@ Function|||Similarity ^@ Belongs to the globin family.|||Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. http://togogenome.org/gene/9595:APCS ^@ http://purl.uniprot.org/uniprot/G3QGL3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pentraxin family.|||Binds 2 calcium ions per subunit.|||Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.|||Secreted http://togogenome.org/gene/9595:ING4 ^@ http://purl.uniprot.org/uniprot/G3RIX2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9595:PALMD ^@ http://purl.uniprot.org/uniprot/G3SE02 ^@ Similarity ^@ Belongs to the paralemmin family. http://togogenome.org/gene/9595:HOXA1 ^@ http://purl.uniprot.org/uniprot/G3QIG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Labial subfamily.|||Nucleus http://togogenome.org/gene/9595:TNFRSF21 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z0W0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:UPF3B ^@ http://purl.uniprot.org/uniprot/G3RUF1|||http://purl.uniprot.org/uniprot/G3RVN9 ^@ Similarity ^@ Belongs to the RENT3 family. http://togogenome.org/gene/9595:RAB18 ^@ http://purl.uniprot.org/uniprot/G3QYG9 ^@ Subcellular Location Annotation ^@ Apical cell membrane|||Cell membrane|||Lipid droplet http://togogenome.org/gene/9595:ZSCAN4 ^@ http://purl.uniprot.org/uniprot/G3QRD7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:DHRS9 ^@ http://purl.uniprot.org/uniprot/G3RCJ0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9595:SYNCRIP ^@ http://purl.uniprot.org/uniprot/G3RAV5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:DCTPP1 ^@ http://purl.uniprot.org/uniprot/G3RMI7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Homotetramer.|||Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.|||cytosol http://togogenome.org/gene/9595:PYROXD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z7N4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.|||sarcomere http://togogenome.org/gene/9595:EPHA5 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZLR6|||http://purl.uniprot.org/uniprot/G3RK16 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:AWAT2 ^@ http://purl.uniprot.org/uniprot/G3QSZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9595:URM1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YGW8|||http://purl.uniprot.org/uniprot/G3RFR8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.|||Belongs to the URM1 family.|||C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.|||Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.|||Cytoplasm http://togogenome.org/gene/9595:MED12L ^@ http://purl.uniprot.org/uniprot/G3RHT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 12 family.|||Nucleus http://togogenome.org/gene/9595:SNX25 ^@ http://purl.uniprot.org/uniprot/G3RLT7 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9595:CCDC126 ^@ http://purl.uniprot.org/uniprot/G3S139 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9595:EGFL6 ^@ http://purl.uniprot.org/uniprot/G3RAM1 ^@ Caution|||Similarity ^@ Belongs to the nephronectin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:HSD17B3 ^@ http://purl.uniprot.org/uniprot/G3QK20 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9595:TNFSF12 ^@ http://purl.uniprot.org/uniprot/A0A2I2YXR1 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9595:UBE2C ^@ http://purl.uniprot.org/uniprot/G3S6I6 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9595:KCNH3 ^@ http://purl.uniprot.org/uniprot/G3QGS8 ^@ Subcellular Location Annotation|||Subunit ^@ Membrane|||The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. http://togogenome.org/gene/9595:LANCL2 ^@ http://purl.uniprot.org/uniprot/G3RIV2 ^@ Similarity ^@ Belongs to the LanC-like protein family. http://togogenome.org/gene/9595:IAPP ^@ http://purl.uniprot.org/uniprot/G3RQX9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calcitonin family.|||Secreted|||Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. http://togogenome.org/gene/9595:LSM8 ^@ http://purl.uniprot.org/uniprot/A0A2I2YFG8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. http://togogenome.org/gene/9595:GNAT1 ^@ http://purl.uniprot.org/uniprot/G3QZZ3 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9595:COPZ1 ^@ http://purl.uniprot.org/uniprot/G3QZ23 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes small subunit family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. http://togogenome.org/gene/9595:ITGA1 ^@ http://purl.uniprot.org/uniprot/G3RPX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9595:TERT ^@ http://purl.uniprot.org/uniprot/G3RW38 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the reverse transcriptase family. Telomerase subfamily.|||Cytoplasm|||Nucleus|||PML body|||Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.|||The RNA-interacting domain 1 (RD1)/N-terminal extension (NTE) is required for interaction with the pseudoknot-template domain of each of TERC dimers. It contains anchor sites that bind primer nucleotides upstream of the RNA-DNA hybrid and is thus an essential determinant of repeat addition processivity.|||The RNA-interacting domain 2 (RD2) is essential for both interaction with the CR4-CR5 domain of TERC and for DNA synthesis.|||The primer grip sequence in the RT domain is required for telomerase activity and for stable association with short telomeric primers.|||nucleolus|||nucleoplasm|||telomere http://togogenome.org/gene/9595:FTMT ^@ http://purl.uniprot.org/uniprot/G3QGN1 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/9595:BMT2 ^@ http://purl.uniprot.org/uniprot/G3S2J7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the BMT2 family.|||Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.|||S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/9595:GJB6 ^@ http://purl.uniprot.org/uniprot/G3QPV8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9595:AGO1 ^@ http://purl.uniprot.org/uniprot/G3QLB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the argonaute family.|||P-body http://togogenome.org/gene/9595:EGFL8 ^@ http://purl.uniprot.org/uniprot/G3QIR3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:HABP2 ^@ http://purl.uniprot.org/uniprot/G3QIP4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9595:GPT2 ^@ http://purl.uniprot.org/uniprot/G3RJK4 ^@ Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/9595:TSEN15 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZQX4|||http://purl.uniprot.org/uniprot/G3RIB6 ^@ Similarity ^@ Belongs to the SEN15 family. http://togogenome.org/gene/9595:AGPAT1 ^@ http://purl.uniprot.org/uniprot/G3RMU5 ^@ Domain|||Function|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/9595:BVES ^@ http://purl.uniprot.org/uniprot/G3RSB1 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/9595:DCN ^@ http://purl.uniprot.org/uniprot/A0A2I2Y4I2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.|||May affect the rate of fibrils formation.|||extracellular matrix http://togogenome.org/gene/9595:B4GALNT1 ^@ http://purl.uniprot.org/uniprot/G3QTX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:HMGB2 ^@ http://purl.uniprot.org/uniprot/G3RII6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/9595:LOC101141762 ^@ http://purl.uniprot.org/uniprot/G3QND7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF9 family.|||Nucleus http://togogenome.org/gene/9595:TMEM107 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZAN6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:CCDC86 ^@ http://purl.uniprot.org/uniprot/G3RCU9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:ATXN3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YJG1|||http://purl.uniprot.org/uniprot/A0A2I2ZJ77 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9595:KDELR3 ^@ http://purl.uniprot.org/uniprot/G3QZ17 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:SYNJ1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y500|||http://purl.uniprot.org/uniprot/G3RIQ1|||http://purl.uniprot.org/uniprot/G3RU85 ^@ Similarity ^@ Belongs to the synaptojanin family.|||In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family. http://togogenome.org/gene/9595:TRIM71 ^@ http://purl.uniprot.org/uniprot/G3RLQ5 ^@ Similarity ^@ Belongs to the TRIM/RBCC family. http://togogenome.org/gene/9595:LTA4H ^@ http://purl.uniprot.org/uniprot/G3QVH4 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit.|||Cytoplasm http://togogenome.org/gene/9595:AR ^@ http://purl.uniprot.org/uniprot/A0A2I2YGE1 ^@ Similarity ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily. http://togogenome.org/gene/9595:RNPS1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZM53|||http://purl.uniprot.org/uniprot/G3SFX8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the splicing factor SR family.|||Found in mRNA splicing-dependent exon junction complexes (EJC). Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively; the ASAP and PSAP complexes probably are formed mutually exclusive. Component of the active spliceosome. Associates with polysomes. Interacts with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1 and TRA2B/SFRS10.|||Nucleus speckle http://togogenome.org/gene/9595:CPB1 ^@ http://purl.uniprot.org/uniprot/G3QRF4 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9595:LOC101150037 ^@ http://purl.uniprot.org/uniprot/G3RU27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:RHOT1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YSS3|||http://purl.uniprot.org/uniprot/A0A2I2ZEP6|||http://purl.uniprot.org/uniprot/G3SDU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial Rho GTPase family.|||Membrane|||Mitochondrial GTPase involved in mitochondrial trafficking.|||Mitochondrion outer membrane http://togogenome.org/gene/9595:ALG14 ^@ http://purl.uniprot.org/uniprot/G3QQ74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG14 family.|||Endoplasmic reticulum membrane|||Membrane|||Nucleus membrane http://togogenome.org/gene/9595:SLC29A1 ^@ http://purl.uniprot.org/uniprot/G3QZ84 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Basolateral cell membrane|||Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9595:CXXC1 ^@ http://purl.uniprot.org/uniprot/G3RLC7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:LOC101146118 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y5S3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:DOK5 ^@ http://purl.uniprot.org/uniprot/G3RW59 ^@ Similarity ^@ Belongs to the DOK family. Type B subfamily. http://togogenome.org/gene/9595:SHQ1 ^@ http://purl.uniprot.org/uniprot/G3SKQ5 ^@ Similarity ^@ Belongs to the SHQ1 family. http://togogenome.org/gene/9595:DYNC1I2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YA06|||http://purl.uniprot.org/uniprot/A0A2I2Z8V6|||http://purl.uniprot.org/uniprot/G3QJQ7|||http://purl.uniprot.org/uniprot/G3SFG3 ^@ Similarity ^@ Belongs to the dynein intermediate chain family. http://togogenome.org/gene/9595:MTRF1L ^@ http://purl.uniprot.org/uniprot/G3SCN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Mitochondrion http://togogenome.org/gene/9595:CLDN9 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z2C4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9595:HSF5 ^@ http://purl.uniprot.org/uniprot/G3RD56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/9595:SLC16A14 ^@ http://purl.uniprot.org/uniprot/G3QIK8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:MARVELD1 ^@ http://purl.uniprot.org/uniprot/G3SIG2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:TAF11 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZH01|||http://purl.uniprot.org/uniprot/G3R9I8 ^@ Similarity ^@ Belongs to the TAF11 family. http://togogenome.org/gene/9595:HAL ^@ http://purl.uniprot.org/uniprot/A0A2I2YY58|||http://purl.uniprot.org/uniprot/G3QVF7 ^@ Similarity ^@ Belongs to the PAL/histidase family. http://togogenome.org/gene/9595:CPLX4 ^@ http://purl.uniprot.org/uniprot/G3QV41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9595:PYGL ^@ http://purl.uniprot.org/uniprot/G3RNK3 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/9595:CAVIN3 ^@ http://purl.uniprot.org/uniprot/G3R2A3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/9595:LOC101147010 ^@ http://purl.uniprot.org/uniprot/A0A2I2YBG8|||http://purl.uniprot.org/uniprot/G3S3P5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9595:SIGMAR1 ^@ http://purl.uniprot.org/uniprot/G3QKA2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ERG2 family.|||Cell junction|||Cytoplasmic vesicle|||Endoplasmic reticulum membrane|||Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.|||Homotrimer.|||Lipid droplet|||Membrane|||Nucleus envelope|||Nucleus inner membrane|||Nucleus outer membrane|||Postsynaptic density membrane|||The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.|||Vesicle|||growth cone http://togogenome.org/gene/9595:CXCR2 ^@ http://purl.uniprot.org/uniprot/G3R144 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:COG2 ^@ http://purl.uniprot.org/uniprot/G3R4J5 ^@ Similarity ^@ Belongs to the COG2 family. http://togogenome.org/gene/9595:GPR68 ^@ http://purl.uniprot.org/uniprot/G3S4M3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:SEZ6 ^@ http://purl.uniprot.org/uniprot/G3R9H9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:LSM3 ^@ http://purl.uniprot.org/uniprot/G3R3E0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/9595:ASZ1 ^@ http://purl.uniprot.org/uniprot/Q2IBF5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.|||Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity). http://togogenome.org/gene/9595:LCA5 ^@ http://purl.uniprot.org/uniprot/G3QXC4 ^@ Similarity ^@ Belongs to the LCA5 family. http://togogenome.org/gene/9595:CUL9 ^@ http://purl.uniprot.org/uniprot/G3QS70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cullin family.|||Cytoplasm http://togogenome.org/gene/9595:PGM1 ^@ http://purl.uniprot.org/uniprot/G3RIU8 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/9595:ATXN1L ^@ http://purl.uniprot.org/uniprot/A0A2I2ZDV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATXN1 family.|||Nucleus http://togogenome.org/gene/9595:GABRR3 ^@ http://purl.uniprot.org/uniprot/G3R834 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9595:RNASE9 ^@ http://purl.uniprot.org/uniprot/Q863K0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pancreatic ribonuclease family.|||Does not exhibit any ribonuclease activity.|||Secreted http://togogenome.org/gene/9595:FOXM1 ^@ http://purl.uniprot.org/uniprot/G3R1V7|||http://purl.uniprot.org/uniprot/G3SAZ9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SEMA5B ^@ http://purl.uniprot.org/uniprot/G3QXA2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:SLC6A7 ^@ http://purl.uniprot.org/uniprot/G3QD03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9595:LOC101138267 ^@ http://purl.uniprot.org/uniprot/G3RGC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:CORO2B ^@ http://purl.uniprot.org/uniprot/G3RB93 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/9595:HNRNPAB ^@ http://purl.uniprot.org/uniprot/A0A2I2ZXJ6|||http://purl.uniprot.org/uniprot/G3R7R0 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9595:B4GALT6 ^@ http://purl.uniprot.org/uniprot/G3QLQ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9595:SLC25A53 ^@ http://purl.uniprot.org/uniprot/G3RJ25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9595:POLR3K ^@ http://purl.uniprot.org/uniprot/G3QZI9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/9595:HIF3A ^@ http://purl.uniprot.org/uniprot/A0A2I2YER8|||http://purl.uniprot.org/uniprot/A0A2I2ZDX2|||http://purl.uniprot.org/uniprot/A0A2I2ZWC7 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/9595:PNCK ^@ http://purl.uniprot.org/uniprot/G3QS15 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:TAF13 ^@ http://purl.uniprot.org/uniprot/G3R267 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:GALNT18 ^@ http://purl.uniprot.org/uniprot/G3QS74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:KAT5 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZJT3|||http://purl.uniprot.org/uniprot/G3S5C2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/9595:PDCD11 ^@ http://purl.uniprot.org/uniprot/G3R7L4 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9595:EOMES ^@ http://purl.uniprot.org/uniprot/G3QZ67 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9595:RPS23 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZQV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS12 family.|||Rough endoplasmic reticulum http://togogenome.org/gene/9595:MT4 ^@ http://purl.uniprot.org/uniprot/G3QR55 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9595:SRD5A3 ^@ http://purl.uniprot.org/uniprot/G3SAM3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).|||Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.|||Endoplasmic reticulum membrane|||Membrane|||Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. http://togogenome.org/gene/9595:E2F3 ^@ http://purl.uniprot.org/uniprot/G3SFQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9595:GANAB ^@ http://purl.uniprot.org/uniprot/A0A2I2Y4E6|||http://purl.uniprot.org/uniprot/G3RCQ0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/9595:BLCAP ^@ http://purl.uniprot.org/uniprot/G3S7R5 ^@ Function|||Similarity ^@ Belongs to the BLCAP family.|||May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B. http://togogenome.org/gene/9595:PRPSAP2 ^@ http://purl.uniprot.org/uniprot/G3RH64 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/9595:ADGRF1 ^@ http://purl.uniprot.org/uniprot/G3SEQ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:TTYH1 ^@ http://purl.uniprot.org/uniprot/G3QQZ4|||http://purl.uniprot.org/uniprot/G3RQL4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tweety family.|||Cell membrane|||Membrane|||Probable chloride channel. http://togogenome.org/gene/9595:SAMD8 ^@ http://purl.uniprot.org/uniprot/A0A2I2YQC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/9595:GPR183 ^@ http://purl.uniprot.org/uniprot/G3QEL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:MTERF2 ^@ http://purl.uniprot.org/uniprot/G3RX35 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/9595:VPS33A ^@ http://purl.uniprot.org/uniprot/G3QRJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STXBP/unc-18/SEC1 family.|||Early endosome|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||clathrin-coated vesicle http://togogenome.org/gene/9595:HSPA8 ^@ http://purl.uniprot.org/uniprot/G3RYM8 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9595:TNS4 ^@ http://purl.uniprot.org/uniprot/G3R2K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTEN phosphatase protein family.|||focal adhesion http://togogenome.org/gene/9595:DCLRE1A ^@ http://purl.uniprot.org/uniprot/G3SF43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/9595:ZSCAN23 ^@ http://purl.uniprot.org/uniprot/G3RNB1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:TMEM33 ^@ http://purl.uniprot.org/uniprot/G3R183 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PER33/POM33 family.|||Membrane http://togogenome.org/gene/9595:IL2RB ^@ http://purl.uniprot.org/uniprot/G3QIL1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 4 subfamily.|||Cell membrane|||Membrane|||Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation. http://togogenome.org/gene/9595:LOC101140204 ^@ http://purl.uniprot.org/uniprot/A0A2I2YNW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 54 family.|||Golgi apparatus membrane http://togogenome.org/gene/9595:HMGCL ^@ http://purl.uniprot.org/uniprot/G3QNX8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HMG-CoA lyase family.|||Homodimer; disulfide-linked. Can also form homotetramers.|||Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. http://togogenome.org/gene/9595:GALC ^@ http://purl.uniprot.org/uniprot/G3RPY6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 59 family. http://togogenome.org/gene/9595:ELP5 ^@ http://purl.uniprot.org/uniprot/G3S9D4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELP5 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:CHST7 ^@ http://purl.uniprot.org/uniprot/G3S3P2 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9595:LOC101150168 ^@ http://purl.uniprot.org/uniprot/G3RQF7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9595:ST8SIA5 ^@ http://purl.uniprot.org/uniprot/G3RD61|||http://purl.uniprot.org/uniprot/G3S807 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9595:TSEN2 ^@ http://purl.uniprot.org/uniprot/G3R9T7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA-intron endonuclease family.|||Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.|||Nucleus http://togogenome.org/gene/9595:EGFLAM ^@ http://purl.uniprot.org/uniprot/A0A2I2YML9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:GPBP1 ^@ http://purl.uniprot.org/uniprot/G3QZA0|||http://purl.uniprot.org/uniprot/G3S8V2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vasculin family.|||Nucleus http://togogenome.org/gene/9595:LOC101142418 ^@ http://purl.uniprot.org/uniprot/G3RC58 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9595:DDX43 ^@ http://purl.uniprot.org/uniprot/G3S041 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9595:ADCYAP1R1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZBZ5|||http://purl.uniprot.org/uniprot/A0A2I2ZHJ5|||http://purl.uniprot.org/uniprot/A0A2I2ZLK4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:EHD4 ^@ http://purl.uniprot.org/uniprot/G3R825 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/9595:PSD2 ^@ http://purl.uniprot.org/uniprot/G3S018 ^@ Subcellular Location Annotation ^@ Membrane|||ruffle membrane http://togogenome.org/gene/9595:FUS ^@ http://purl.uniprot.org/uniprot/G3RPN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TET family.|||Nucleus http://togogenome.org/gene/9595:TJP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZAR7|||http://purl.uniprot.org/uniprot/A0A2I2ZAW3|||http://purl.uniprot.org/uniprot/A0A2I2ZVU8|||http://purl.uniprot.org/uniprot/G3SE59 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9595:SLC37A2 ^@ http://purl.uniprot.org/uniprot/G3RHQ0|||http://purl.uniprot.org/uniprot/G3RTK5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.|||Membrane http://togogenome.org/gene/9595:NF2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YM46|||http://purl.uniprot.org/uniprot/A0A2I2YZG5|||http://purl.uniprot.org/uniprot/A0A2I2ZFQ4 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/9595:KCNA5 ^@ http://purl.uniprot.org/uniprot/G3R8M9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:N4BP3 ^@ http://purl.uniprot.org/uniprot/G3QCR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the N4BP3 family.|||Vesicle|||dendrite http://togogenome.org/gene/9595:PHOSPHO1 ^@ http://purl.uniprot.org/uniprot/G3QHU0 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. PHOSPHO family. http://togogenome.org/gene/9595:LOC101148603 ^@ http://purl.uniprot.org/uniprot/G3RK00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:GTPBP4 ^@ http://purl.uniprot.org/uniprot/G3RC29 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.|||Involved in the biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/9595:MPV17L2 ^@ http://purl.uniprot.org/uniprot/G3R0J7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/9595:STYXL2 ^@ http://purl.uniprot.org/uniprot/G3QPE2 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9595:ACSL4 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y442|||http://purl.uniprot.org/uniprot/G3QZV5 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9595:CDC25C ^@ http://purl.uniprot.org/uniprot/G3QEW4 ^@ Function|||Similarity ^@ Belongs to the MPI phosphatase family.|||Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. http://togogenome.org/gene/9595:CNDP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z7W3 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20A family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9595:FOXJ1 ^@ http://purl.uniprot.org/uniprot/G3QWG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FOXJ1 family.|||Nucleus http://togogenome.org/gene/9595:BNIP3 ^@ http://purl.uniprot.org/uniprot/G3RF13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIP3 family.|||Membrane http://togogenome.org/gene/9595:FAM166C ^@ http://purl.uniprot.org/uniprot/G3R576 ^@ Similarity ^@ Belongs to the CIMIP2 family. http://togogenome.org/gene/9595:LOC101148853 ^@ http://purl.uniprot.org/uniprot/A0A2I2YM80 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9595:NDUFA10 ^@ http://purl.uniprot.org/uniprot/Q0MQB6 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA10 subunit family.|||Binds 1 FAD per subunit.|||Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.|||Mitochondrion matrix|||Phosphorylation at Ser-250 by PINK1 is required for the binding and/or reduction of the complex I substrate ubiquinone. http://togogenome.org/gene/9595:CA7 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZVT0|||http://purl.uniprot.org/uniprot/G3RF47 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9595:DPAGT1 ^@ http://purl.uniprot.org/uniprot/G3QYF6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family.|||Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:SLC6A20 ^@ http://purl.uniprot.org/uniprot/G3QI65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9595:ASB6 ^@ http://purl.uniprot.org/uniprot/G3QJN5 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9595:RPS12 ^@ http://purl.uniprot.org/uniprot/G3R953 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS12 family. http://togogenome.org/gene/9595:CALB1 ^@ http://purl.uniprot.org/uniprot/G3QQH3 ^@ Function|||Similarity ^@ Belongs to the calbindin family.|||Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. http://togogenome.org/gene/9595:BMP3 ^@ http://purl.uniprot.org/uniprot/G3QR41 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer.|||Secreted http://togogenome.org/gene/9595:CMTM5 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y6F2|||http://purl.uniprot.org/uniprot/G3S5C1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:NUDT3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZRG2 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DIPP subfamily. http://togogenome.org/gene/9595:HSPB7 ^@ http://purl.uniprot.org/uniprot/G3QY36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Nucleus http://togogenome.org/gene/9595:GDPD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YEU8 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9595:ADD2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YDZ2 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/9595:HBP1 ^@ http://purl.uniprot.org/uniprot/G3QXR1 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4. http://togogenome.org/gene/9595:LOC101144524 ^@ http://purl.uniprot.org/uniprot/G3QT78 ^@ Function|||Similarity ^@ Belongs to the PET191 family.|||Involved in an early step of the mitochondrial complex IV assembly process. http://togogenome.org/gene/9595:CREBBP ^@ http://purl.uniprot.org/uniprot/A0A2I2YD30 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:NIPA2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y571 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9595:ETV3L ^@ http://purl.uniprot.org/uniprot/G3QIZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9595:LOC101137537 ^@ http://purl.uniprot.org/uniprot/G3QKH6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/9595:FCN2 ^@ http://purl.uniprot.org/uniprot/G3SI20 ^@ Similarity ^@ Belongs to the ficolin lectin family. http://togogenome.org/gene/9595:MIS12 ^@ http://purl.uniprot.org/uniprot/G3R4Z8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mis12 family.|||Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3, CBX5, NDC80 and ZWINT.|||kinetochore http://togogenome.org/gene/9595:F13B ^@ http://purl.uniprot.org/uniprot/G3RK04 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:SRPRA ^@ http://purl.uniprot.org/uniprot/G3RB09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding SRP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:SIRT2 ^@ http://purl.uniprot.org/uniprot/G3QJ69 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the sirtuin family. Class I subfamily.|||Binds 1 zinc ion per subunit.|||NAD-dependent protein deacetylase. http://togogenome.org/gene/9595:RAD52 ^@ http://purl.uniprot.org/uniprot/G3QUD4 ^@ Similarity ^@ Belongs to the RAD52 family. http://togogenome.org/gene/9595:PACSIN1 ^@ http://purl.uniprot.org/uniprot/G3RRV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PACSIN family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||cytosol|||ruffle membrane|||synaptosome http://togogenome.org/gene/9595:THEMIS ^@ http://purl.uniprot.org/uniprot/G3RI95 ^@ Similarity ^@ Belongs to the themis family. http://togogenome.org/gene/9595:AP1S2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YN18|||http://purl.uniprot.org/uniprot/A0A2I2ZIX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||Membrane|||clathrin-coated pit http://togogenome.org/gene/9595:LOC101134278 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZN71 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9595:CRHBP ^@ http://purl.uniprot.org/uniprot/A0A2I2YML7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CRF-binding protein family.|||Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.|||Secreted http://togogenome.org/gene/9595:LOC101137284 ^@ http://purl.uniprot.org/uniprot/G3S2U0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:PRKD3 ^@ http://purl.uniprot.org/uniprot/G3RL70 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by DAG and phorbol esters.|||Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/9595:SLC6A6 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZC31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:PQBP1 ^@ http://purl.uniprot.org/uniprot/A1YFA7 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasmic granule|||Except for the WW domain, the protein is intrinsically disordered.|||Interacts with POU3F2/Brn-2, ATXN1, TXNL4A, HTT and AR. Interaction with ATXN1 correlates positively with the length of the polyglutamine tract. Interacts with RNA polymerase II large subunit in a phosphorylation-dependent manner. Forms a ternary complex with ATXN1 mutant and phosphorylated RNA polymerase II. Interacts (via C-terminus) with TXNL4A and CD2BP2. Interacts (via WW domain) with ATN1 and SF3B1, and may interact with additional splice factors. Interacts (via WW domain) with WBP11; Leading to reduce interaction between PQBP1 and TXNL4A. Interacts with CAPRIN1. Interacts with DDX1. Interacts with SFPQ. Interacts with KHSRP.|||Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development. Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit. Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules. Also acts as an innate immune sensor of infection by retroviruses, by detecting the presence of reverse-transcribed DNA in the cytosol. Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production.|||Nucleus|||Nucleus speckle|||The WW domain may play a role as a transcriptional activator directly or via association with the transcription machinery. The WW domain mediates interaction with WBP11, ATN1, SF3B1 and the C-terminal domain of the RNA polymerase II large subunit. http://togogenome.org/gene/9595:LOC101143299 ^@ http://purl.uniprot.org/uniprot/G3R7E3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS26 family. http://togogenome.org/gene/9595:PIGM ^@ http://purl.uniprot.org/uniprot/G3S4N0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGM family.|||Endoplasmic reticulum membrane|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.|||Membrane http://togogenome.org/gene/9595:UBE2L6 ^@ http://purl.uniprot.org/uniprot/G3QR90|||http://purl.uniprot.org/uniprot/G3SCR6 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9595:HNRNPDL ^@ http://purl.uniprot.org/uniprot/G3QMB5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9595:TSC22D1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZLV8|||http://purl.uniprot.org/uniprot/G3RAR2 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/9595:PDSS1 ^@ http://purl.uniprot.org/uniprot/G3R7M7 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9595:F2R ^@ http://purl.uniprot.org/uniprot/G3R4I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ENO1 ^@ http://purl.uniprot.org/uniprot/G3R4B2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/9595:FGG ^@ http://purl.uniprot.org/uniprot/A0A2I2YC21|||http://purl.uniprot.org/uniprot/G3R8D4 ^@ Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted http://togogenome.org/gene/9595:MLLT3 ^@ http://purl.uniprot.org/uniprot/G3QPC5|||http://purl.uniprot.org/uniprot/G3RWF8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:GADD45A ^@ http://purl.uniprot.org/uniprot/G3R5D8 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/9595:CENPS ^@ http://purl.uniprot.org/uniprot/G3RAC8 ^@ Similarity ^@ Belongs to the TAF9 family. CENP-S/MHF1 subfamily. http://togogenome.org/gene/9595:MYOF ^@ http://purl.uniprot.org/uniprot/G3RT91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ferlin family.|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/9595:ELP2 ^@ http://purl.uniprot.org/uniprot/G3RMC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat ELP2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:SLC25A35 ^@ http://purl.uniprot.org/uniprot/G3R668 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9595:BDH1 ^@ http://purl.uniprot.org/uniprot/G3R6E1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9595:MMP1 ^@ http://purl.uniprot.org/uniprot/G3R0I7 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9595:GIMAP7 ^@ http://purl.uniprot.org/uniprot/G3QIU4 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9595:SEC24A ^@ http://purl.uniprot.org/uniprot/A0A2I2ZV96|||http://purl.uniprot.org/uniprot/G3R641 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9595:CLDN17 ^@ http://purl.uniprot.org/uniprot/G3QFD9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9595:MTERF1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZHH1 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/9595:FAM13C ^@ http://purl.uniprot.org/uniprot/A0A2I2ZS22|||http://purl.uniprot.org/uniprot/G3RTH3 ^@ Similarity ^@ Belongs to the FAM13 family. http://togogenome.org/gene/9595:JUNB ^@ http://purl.uniprot.org/uniprot/A0A2I2ZDY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. Jun subfamily.|||Nucleus http://togogenome.org/gene/9595:RRP1B ^@ http://purl.uniprot.org/uniprot/G3R8R6 ^@ Similarity ^@ Belongs to the RRP1 family. http://togogenome.org/gene/9595:TMPRSS6 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZQU0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:PIP4P1 ^@ http://purl.uniprot.org/uniprot/G3QI92 ^@ Function|||Subcellular Location Annotation ^@ Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane|||phagosome membrane http://togogenome.org/gene/9595:E2F1 ^@ http://purl.uniprot.org/uniprot/G3QM04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9595:MVP ^@ http://purl.uniprot.org/uniprot/G3RHU8 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. http://togogenome.org/gene/9595:MRPS24 ^@ http://purl.uniprot.org/uniprot/G3QSD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS3 family.|||Mitochondrion http://togogenome.org/gene/9595:NDUFS8 ^@ http://purl.uniprot.org/uniprot/Q0MQI2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 23 kDa subunit family.|||Binds 2 [4Fe-4S] cluster.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (By similarity). This is a component of the iron-sulfur (IP) fragment of the enzyme (By similarity). Interacts with RAB5IF (By similarity).|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (By similarity). Essential for the catalytic activity and assembly of complex I (By similarity).|||Mitochondrion inner membrane http://togogenome.org/gene/9595:ADIPOR1 ^@ http://purl.uniprot.org/uniprot/G3QQZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9595:PTAFR ^@ http://purl.uniprot.org/uniprot/G3REF4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with ARRB1.|||Membrane|||Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9595:PDHA2 ^@ http://purl.uniprot.org/uniprot/G3RD19 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. http://togogenome.org/gene/9595:MAPK7 ^@ http://purl.uniprot.org/uniprot/G3QTA1 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9595:CCT7 ^@ http://purl.uniprot.org/uniprot/G3QXP9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm|||Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.|||Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. http://togogenome.org/gene/9595:FGR ^@ http://purl.uniprot.org/uniprot/G3QER4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9595:TMEM200A ^@ http://purl.uniprot.org/uniprot/G3RBN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM200 family.|||Membrane http://togogenome.org/gene/9595:CNFN ^@ http://purl.uniprot.org/uniprot/G3QEP9 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/9595:EGR3 ^@ http://purl.uniprot.org/uniprot/G3QJ13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/9595:TBR1 ^@ http://purl.uniprot.org/uniprot/G3RS35 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9595:CDC42EP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZUQ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system|||Probably involved in the organization of the actin cytoskeleton.|||cytoskeleton http://togogenome.org/gene/9595:SETDB1 ^@ http://purl.uniprot.org/uniprot/G3RJM2 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus http://togogenome.org/gene/9595:KCNK16 ^@ http://purl.uniprot.org/uniprot/G3QXC1|||http://purl.uniprot.org/uniprot/G3SGQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9595:SRD5A1 ^@ http://purl.uniprot.org/uniprot/G3RKC3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.|||Membrane|||Microsome membrane http://togogenome.org/gene/9595:ARL8A ^@ http://purl.uniprot.org/uniprot/G3S521 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||axon|||spindle http://togogenome.org/gene/9595:TPMT ^@ http://purl.uniprot.org/uniprot/Q3BCR3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9595:GLRA3 ^@ http://purl.uniprot.org/uniprot/G3QU31 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/9595:ATP6V1F ^@ http://purl.uniprot.org/uniprot/G3RZ22 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase F subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9595:ALDH1A3 ^@ http://purl.uniprot.org/uniprot/G3QCV7 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9595:FGD1 ^@ http://purl.uniprot.org/uniprot/G3QY89 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9595:ERCC2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZV36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RAD3/XPD subfamily.|||Nucleus http://togogenome.org/gene/9595:HLF ^@ http://purl.uniprot.org/uniprot/G3QTC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/9595:TRHDE ^@ http://purl.uniprot.org/uniprot/G3R602 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9595:P2RY13 ^@ http://purl.uniprot.org/uniprot/G3REZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:LOXL1 ^@ http://purl.uniprot.org/uniprot/G3RFS3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/9595:SERINC3 ^@ http://purl.uniprot.org/uniprot/G3RHA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9595:PRR15 ^@ http://purl.uniprot.org/uniprot/A0A2I2YZD5 ^@ Similarity ^@ Belongs to the PRR15 family. http://togogenome.org/gene/9595:LOC101142172 ^@ http://purl.uniprot.org/uniprot/G3SGI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:SETDB2 ^@ http://purl.uniprot.org/uniprot/G3S799 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/9595:HKDC1 ^@ http://purl.uniprot.org/uniprot/G3R9K6 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/9595:MRPS33 ^@ http://purl.uniprot.org/uniprot/G3R292 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS33 family.|||Mitochondrion http://togogenome.org/gene/9595:CEP63 ^@ http://purl.uniprot.org/uniprot/A0A2I2YUF7|||http://purl.uniprot.org/uniprot/A0A2I2Z5Q1|||http://purl.uniprot.org/uniprot/A0A2I2Z6P4 ^@ Similarity ^@ Belongs to the CEP63 family. http://togogenome.org/gene/9595:RASSF1 ^@ http://purl.uniprot.org/uniprot/G3QW11 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9595:USP39 ^@ http://purl.uniprot.org/uniprot/G3QGA8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SLC24A5 ^@ http://purl.uniprot.org/uniprot/G3RGP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/9595:TAS2R7 ^@ http://purl.uniprot.org/uniprot/G3S7B2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9595:PROK1 ^@ http://purl.uniprot.org/uniprot/G3QZB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AVIT (prokineticin) family.|||Secreted http://togogenome.org/gene/9595:MYD88 ^@ http://purl.uniprot.org/uniprot/B3Y680 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses, induces IL1B release through NLRP3 inflammasome activation (By similarity). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity).|||Cytoplasm|||Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, TLR5, IRAK1, IRAK2 and IRAK4 via their respective TIR domains. Interacts with IL18R1. Interacts with BMX, IL1RL1, IKBKE and IRF7. Interacts with LRRFIP1 and LRRFIP2; this interaction positively regulates Toll-like receptor (TLR) signaling in response to agonist. Interacts with FLII. LRRFIP1 and LRRFIP2 compete with FLII for MYD88-binding. Interacts with IRF1. Upon IL1B treatment, forms a complex with PELI1, IRAK1, IRAK4 and TRAF6; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression. May interact with PIK3AP1. Interacts (via TIR domain) with DHX9 (via H2A and OB-fold regions); this interaction is direct.Interacts with OTUD4 deubiquitinase; the interaction is direct.|||Nucleus|||The intermediate domain (ID) is required for the phosphorylation and activation of IRAK.|||Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination. OTUD4 specifically hydrolyzes 'Lys-63'-linked polyubiquitinated MYD88. http://togogenome.org/gene/9595:SLC35A5 ^@ http://purl.uniprot.org/uniprot/G3SGE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:TCTN2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z6V2 ^@ Similarity|||Subunit ^@ Belongs to the tectonic family.|||Part of the tectonic-like complex (also named B9 complex). http://togogenome.org/gene/9595:CENPK ^@ http://purl.uniprot.org/uniprot/G3QQX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-K/MCM22 family.|||Nucleus|||centromere http://togogenome.org/gene/9595:DNMBP ^@ http://purl.uniprot.org/uniprot/A0A2I2Z4Z2 ^@ Subcellular Location Annotation ^@ Cell junction|||Golgi stack http://togogenome.org/gene/9595:LLGL1 ^@ http://purl.uniprot.org/uniprot/G3QKN5 ^@ Similarity ^@ Belongs to the WD repeat L(2)GL family. http://togogenome.org/gene/9595:HSDL2 ^@ http://purl.uniprot.org/uniprot/G3S6V2 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/9595:SLC25A4 ^@ http://purl.uniprot.org/uniprot/A0A2I2YVC0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/9595:SPIN4 ^@ http://purl.uniprot.org/uniprot/G3QJS7 ^@ Similarity ^@ Belongs to the SPIN/STSY family. http://togogenome.org/gene/9595:BOD1L2 ^@ http://purl.uniprot.org/uniprot/G3S6W3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BOD1 family.|||centrosome|||kinetochore http://togogenome.org/gene/9595:IL13RA1 ^@ http://purl.uniprot.org/uniprot/G3RFC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 5 subfamily.|||Membrane http://togogenome.org/gene/9595:EPHA1 ^@ http://purl.uniprot.org/uniprot/G3QCY0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:SLC25A5 ^@ http://purl.uniprot.org/uniprot/G3REE3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/9595:TONSL ^@ http://purl.uniprot.org/uniprot/G3RJF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tonsoku family.|||Chromosome http://togogenome.org/gene/9595:PMPCA ^@ http://purl.uniprot.org/uniprot/G3R5R1 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/9595:PPAT ^@ http://purl.uniprot.org/uniprot/G3QPM3 ^@ Cofactor|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/9595:LOC101139006 ^@ http://purl.uniprot.org/uniprot/G3QG82 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:LOC101138014 ^@ http://purl.uniprot.org/uniprot/G3RV10 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:DCLK1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y344|||http://purl.uniprot.org/uniprot/G3QUA9 ^@ Similarity ^@ Belongs to the protein kinase superfamily.|||Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9595:CLIC3 ^@ http://purl.uniprot.org/uniprot/G3R7M3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/9595:MED26 ^@ http://purl.uniprot.org/uniprot/G3S035 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 26 family.|||Nucleus http://togogenome.org/gene/9595:GYS2 ^@ http://purl.uniprot.org/uniprot/G3QU91 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase 3 family.|||Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. http://togogenome.org/gene/9595:ARMC9 ^@ http://purl.uniprot.org/uniprot/G3QJE1 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with TOGARAM1, CCDC66, CEP104, CSPP1 and CEP290.|||centriole|||cilium|||cilium basal body http://togogenome.org/gene/9595:NES ^@ http://purl.uniprot.org/uniprot/G3S250 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:AKIRIN1 ^@ http://purl.uniprot.org/uniprot/G3QTA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus http://togogenome.org/gene/9595:POLE2 ^@ http://purl.uniprot.org/uniprot/G3RX47 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase epsilon subunit B family.|||Nucleus|||Participates in DNA repair and in chromosomal DNA replication. http://togogenome.org/gene/9595:KHDRBS1 ^@ http://purl.uniprot.org/uniprot/G3QZW8 ^@ Similarity ^@ Belongs to the KHDRBS family. http://togogenome.org/gene/9595:PSMC1 ^@ http://purl.uniprot.org/uniprot/G3R4Z3 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9595:TLX1 ^@ http://purl.uniprot.org/uniprot/G3S1Q9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SEMA7A ^@ http://purl.uniprot.org/uniprot/G3QUI5 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:ACTN2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZV52|||http://purl.uniprot.org/uniprot/G3R8C5 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/9595:TMEM267 ^@ http://purl.uniprot.org/uniprot/G3QQB7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:NLGN4X ^@ http://purl.uniprot.org/uniprot/G3S197 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:VCAM1 ^@ http://purl.uniprot.org/uniprot/G3QL75 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9595:CSE1L ^@ http://purl.uniprot.org/uniprot/G3SCL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPO2/CSE1 family.|||Cytoplasm http://togogenome.org/gene/9595:BAK1 ^@ http://purl.uniprot.org/uniprot/G3RSX3 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9595:CCDC124 ^@ http://purl.uniprot.org/uniprot/G3QP06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC124 family.|||Midbody http://togogenome.org/gene/9595:ATP4B ^@ http://purl.uniprot.org/uniprot/G3R8V1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9595:CEBPB ^@ http://purl.uniprot.org/uniprot/A0A2I2ZBE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. C/EBP subfamily.|||Nucleus http://togogenome.org/gene/9595:KIF24 ^@ http://purl.uniprot.org/uniprot/G3QEH0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9595:SFXN4 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZE28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Membrane http://togogenome.org/gene/9595:LTF ^@ http://purl.uniprot.org/uniprot/G3QYG5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transferrin family.|||Cytoplasmic granule|||Secreted|||Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. http://togogenome.org/gene/9595:MIEF1 ^@ http://purl.uniprot.org/uniprot/G3SJU6 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9595:NRG3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZMU8 ^@ Caution|||Similarity ^@ Belongs to the neuregulin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:TNFSF10 ^@ http://purl.uniprot.org/uniprot/G3RF33 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Homotrimer.|||Membrane|||Secreted http://togogenome.org/gene/9595:EMC1 ^@ http://purl.uniprot.org/uniprot/G3QE37 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC1 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:NASP ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1E4|||http://purl.uniprot.org/uniprot/G3S5W1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NASP family.|||Nucleus http://togogenome.org/gene/9595:SLC17A3 ^@ http://purl.uniprot.org/uniprot/G3SJE4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:LOC101150395 ^@ http://purl.uniprot.org/uniprot/A0A2I2YH71 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:FZD5 ^@ http://purl.uniprot.org/uniprot/A0A2I2YRF3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:LOC101149653 ^@ http://purl.uniprot.org/uniprot/G3RA96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:LOC101133112 ^@ http://purl.uniprot.org/uniprot/G3REG1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:SH3GL2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y4S8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Membrane http://togogenome.org/gene/9595:ITGAD ^@ http://purl.uniprot.org/uniprot/G3QTG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9595:CBX8 ^@ http://purl.uniprot.org/uniprot/G3QPR3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:TMEM198 ^@ http://purl.uniprot.org/uniprot/G3QM05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM198 family.|||Membrane http://togogenome.org/gene/9595:RPL12 ^@ http://purl.uniprot.org/uniprot/G3QEE4 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL11 family.|||Binds directly to 26S ribosomal RNA. http://togogenome.org/gene/9595:STAM2 ^@ http://purl.uniprot.org/uniprot/G3R732 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the STAM family.|||Early endosome membrane|||Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. http://togogenome.org/gene/9595:CBFA2T2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z9T5|||http://purl.uniprot.org/uniprot/A0A2I2ZC47 ^@ Similarity ^@ Belongs to the CBFA2T family. http://togogenome.org/gene/9595:HSP90AB1 ^@ http://purl.uniprot.org/uniprot/G3R0K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 90 family.|||Melanosome http://togogenome.org/gene/9595:SNTA1 ^@ http://purl.uniprot.org/uniprot/G3QZK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntrophin family.|||Cell junction|||cytoskeleton http://togogenome.org/gene/9595:SCN1B ^@ http://purl.uniprot.org/uniprot/G3QQT7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:URGCP ^@ http://purl.uniprot.org/uniprot/A0A2I2Y1N5|||http://purl.uniprot.org/uniprot/A0A2I2Z8Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.|||Nucleus http://togogenome.org/gene/9595:ZNF280A ^@ http://purl.uniprot.org/uniprot/G3S5R8 ^@ Function|||Subcellular Location Annotation ^@ May function as a transcription factor.|||Nucleus http://togogenome.org/gene/9595:TXNRD1 ^@ http://purl.uniprot.org/uniprot/G3RS10 ^@ Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. http://togogenome.org/gene/9595:KRT78 ^@ http://purl.uniprot.org/uniprot/G3QMQ7 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:KCNH8 ^@ http://purl.uniprot.org/uniprot/G3RMV3 ^@ Subcellular Location Annotation|||Subunit ^@ Membrane|||The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. http://togogenome.org/gene/9595:PFN1 ^@ http://purl.uniprot.org/uniprot/G3S0W1 ^@ Similarity ^@ Belongs to the profilin family. http://togogenome.org/gene/9595:ANKRD13A ^@ http://purl.uniprot.org/uniprot/G3R232 ^@ Function|||Subcellular Location Annotation ^@ Endosome|||Late endosome|||Membrane|||Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. http://togogenome.org/gene/9595:TMEM106C ^@ http://purl.uniprot.org/uniprot/G3QNU6 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/9595:TPM1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZAB7|||http://purl.uniprot.org/uniprot/A0A2I2ZKG9|||http://purl.uniprot.org/uniprot/G3R169|||http://purl.uniprot.org/uniprot/G3RWR8|||http://purl.uniprot.org/uniprot/G3S1U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9595:CFLAR ^@ http://purl.uniprot.org/uniprot/G3R5V9 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9595:DUS4L ^@ http://purl.uniprot.org/uniprot/G3QML1 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. http://togogenome.org/gene/9595:LAPTM5 ^@ http://purl.uniprot.org/uniprot/G3RLG7 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/9595:LOC101141497 ^@ http://purl.uniprot.org/uniprot/G3R9Y1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the p22phox family.|||Cell membrane|||Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).|||Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.|||Membrane http://togogenome.org/gene/9595:DHX29 ^@ http://purl.uniprot.org/uniprot/G3QHK6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.|||Belongs to the DEAD box helicase family. DEAH subfamily.|||Cytoplasm|||Part of the 43S pre-initiation complex (PIC) that contains at least Met-tRNA, EIF1, EIF1A (EIF1AX or EIF1AY), EIF2S1, EIF2S2, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L, EIF3M, DHX29 and the 40S ribosomal subunit. http://togogenome.org/gene/9595:NUP155 ^@ http://purl.uniprot.org/uniprot/G3RZ49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the non-repetitive/WGA-negative nucleoporin family.|||nuclear pore complex http://togogenome.org/gene/9595:FFAR2 ^@ http://purl.uniprot.org/uniprot/G3QSU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:LOC101130814 ^@ http://purl.uniprot.org/uniprot/G3RRH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:RIPPLY1 ^@ http://purl.uniprot.org/uniprot/G3QRS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ripply family.|||Nucleus http://togogenome.org/gene/9595:FNBP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1L0|||http://purl.uniprot.org/uniprot/A0A2I2Z1V6|||http://purl.uniprot.org/uniprot/A0A2I2Z406 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9595:LIN7C ^@ http://purl.uniprot.org/uniprot/G3RYG3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the lin-7 family.|||Cell membrane|||Lateral cell membrane|||Membrane|||Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.|||Postsynaptic density membrane|||tight junction http://togogenome.org/gene/9595:ID3 ^@ http://purl.uniprot.org/uniprot/G3QZD1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:DPH1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z179 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the DPH1/DPH2 family. DPH1 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. http://togogenome.org/gene/9595:SS18L2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZM28 ^@ Similarity ^@ Belongs to the SS18 family. http://togogenome.org/gene/9595:LOC109027306 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZZ53 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9595:NDUFB10 ^@ http://purl.uniprot.org/uniprot/Q0MQF2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.|||Belongs to the complex I NDUFB10 subunit family.|||Complex I is composed of 45 different subunits. Interacts with CHCHD4.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:ARL2BP ^@ http://purl.uniprot.org/uniprot/G3QRU4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARL2BP family.|||Cytoplasm|||Mitochondrion intermembrane space|||Nucleus|||Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.|||centrosome|||cilium basal body http://togogenome.org/gene/9595:SYNJ2 ^@ http://purl.uniprot.org/uniprot/G3R949|||http://purl.uniprot.org/uniprot/G3RRS3 ^@ Similarity ^@ Belongs to the synaptojanin family.|||In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family. http://togogenome.org/gene/9595:CLDN12 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y704 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Membrane|||tight junction http://togogenome.org/gene/9595:LOC101139737 ^@ http://purl.uniprot.org/uniprot/G3R411 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:NXPH2 ^@ http://purl.uniprot.org/uniprot/G3RWC9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/9595:CHST13 ^@ http://purl.uniprot.org/uniprot/G3RDQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:DDX1 ^@ http://purl.uniprot.org/uniprot/G3R9U8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DDX1 subfamily.|||Cytoplasmic granule|||RNA helicase.|||The helicase domain is involved in the stimulation of RELA transcriptional activity. http://togogenome.org/gene/9595:TAS2R8 ^@ http://purl.uniprot.org/uniprot/Q646A3 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane|||Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.|||Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). http://togogenome.org/gene/9595:NTMT1 ^@ http://purl.uniprot.org/uniprot/G3QJN0 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. NTM1 family. http://togogenome.org/gene/9595:NPSR1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZKT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:NANOS2 ^@ http://purl.uniprot.org/uniprot/G3RC89 ^@ Similarity ^@ Belongs to the nanos family. http://togogenome.org/gene/9595:PIANP ^@ http://purl.uniprot.org/uniprot/G3SIQ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:LOC101153414 ^@ http://purl.uniprot.org/uniprot/G3RXT8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9595:NME6 ^@ http://purl.uniprot.org/uniprot/A0A2I2YRA6 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9595:DMAP1 ^@ http://purl.uniprot.org/uniprot/G3QLW4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:FAM83F ^@ http://purl.uniprot.org/uniprot/G3QVF6 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9595:TIPIN ^@ http://purl.uniprot.org/uniprot/G3QCW0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSM3 family.|||Nucleus|||Plays an important role in the control of DNA replication and the maintenance of replication fork stability. http://togogenome.org/gene/9595:EIF4E3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z4K7 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/9595:AQP1 ^@ http://purl.uniprot.org/uniprot/G3R332 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9595:EIF4A2 ^@ http://purl.uniprot.org/uniprot/G3QSU6 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family. eIF4A subfamily.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9595:BRINP1 ^@ http://purl.uniprot.org/uniprot/G3QR50 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/9595:ELAVL2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZC03|||http://purl.uniprot.org/uniprot/G3SGG8 ^@ Similarity ^@ Belongs to the RRM elav family. http://togogenome.org/gene/9595:TRPM3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y5U9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:FUCA2 ^@ http://purl.uniprot.org/uniprot/G3R6L9 ^@ Function|||Similarity|||Subunit ^@ Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.|||Belongs to the glycosyl hydrolase 29 family.|||Homotetramer. http://togogenome.org/gene/9595:KAT2B ^@ http://purl.uniprot.org/uniprot/G3RKM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. GCN5 subfamily.|||Nucleus|||centrosome http://togogenome.org/gene/9595:ZNF703 ^@ http://purl.uniprot.org/uniprot/G3R800 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Elbow/Noc family.|||Nucleus http://togogenome.org/gene/9595:VDR ^@ http://purl.uniprot.org/uniprot/G3RK17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:SEMA3F ^@ http://purl.uniprot.org/uniprot/A0A2I2YT32|||http://purl.uniprot.org/uniprot/A0A2I2YUI3 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:C11H11orf54 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y5F9|||http://purl.uniprot.org/uniprot/G3RFI0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.|||Monomer.|||Nucleus http://togogenome.org/gene/9595:AGL ^@ http://purl.uniprot.org/uniprot/A0A2I2YDM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycogen debranching enzyme family.|||Cytoplasm|||Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. http://togogenome.org/gene/9595:CIAO1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZVX0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the WD repeat CIA1 family.|||Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.|||Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. http://togogenome.org/gene/9595:LOC101131885 ^@ http://purl.uniprot.org/uniprot/G3S4Z9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9595:HEBP2 ^@ http://purl.uniprot.org/uniprot/G3QGU6 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/9595:ARG1 ^@ http://purl.uniprot.org/uniprot/G3RRL0 ^@ Cofactor|||Similarity ^@ Belongs to the arginase family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9595:SPRR2G ^@ http://purl.uniprot.org/uniprot/A0A2I2Z4I8 ^@ Similarity ^@ Belongs to the cornifin (SPRR) family. http://togogenome.org/gene/9595:TOR1AIP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZRA2|||http://purl.uniprot.org/uniprot/G3RDA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TOR1AIP family.|||Membrane http://togogenome.org/gene/9595:PFAS ^@ http://purl.uniprot.org/uniprot/G3QZU5 ^@ Similarity ^@ In the N-terminal section; belongs to the FGAMS family. http://togogenome.org/gene/9595:LOC101142132 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y3S5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9595:ESF1 ^@ http://purl.uniprot.org/uniprot/G3QUZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESF1 family.|||nucleolus http://togogenome.org/gene/9595:LOC101148684 ^@ http://purl.uniprot.org/uniprot/G3SKC3 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/9595:STN1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YS00|||http://purl.uniprot.org/uniprot/A0A2I2YUX3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the STN1 family.|||Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.|||Component of the CST complex.|||Nucleus|||telomere http://togogenome.org/gene/9595:BNIP1 ^@ http://purl.uniprot.org/uniprot/G3QIJ2|||http://purl.uniprot.org/uniprot/G3SHW1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:CSF3R ^@ http://purl.uniprot.org/uniprot/G3S1M9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/9595:WNT8B ^@ http://purl.uniprot.org/uniprot/G3RFB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9595:GINS1 ^@ http://purl.uniprot.org/uniprot/G3QJ52 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS1/PSF1 family.|||Chromosome|||Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex.|||Nucleus|||Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. http://togogenome.org/gene/9595:NTSR1 ^@ http://purl.uniprot.org/uniprot/G3RLF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:EPOR ^@ http://purl.uniprot.org/uniprot/G3RT53 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||Forms homodimers on EPO stimulation.|||Membrane|||Receptor for erythropoietin. http://togogenome.org/gene/9595:LOC109023678 ^@ http://purl.uniprot.org/uniprot/G3RQM3 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9595:DSCC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZVY3 ^@ Similarity ^@ Belongs to the DCC1 family. http://togogenome.org/gene/9595:SNX10 ^@ http://purl.uniprot.org/uniprot/G3S6L1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane http://togogenome.org/gene/9595:CCNB1 ^@ http://purl.uniprot.org/uniprot/G3QGP3 ^@ Function|||Similarity ^@ Belongs to the cyclin family.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition. http://togogenome.org/gene/9595:ADGRD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YC34|||http://purl.uniprot.org/uniprot/A0A2I2YZY1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:IGBP1 ^@ http://purl.uniprot.org/uniprot/G3RW45 ^@ Similarity ^@ Belongs to the IGBP1/TAP42 family. http://togogenome.org/gene/9595:SUSD5 ^@ http://purl.uniprot.org/uniprot/A0A2I2YKD5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:ZNF16 ^@ http://purl.uniprot.org/uniprot/A1YF12 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Also plays a role as an inhibitor of cell apoptosis (By similarity).|||Belongs to the krueppel C2H2-type zinc-finger protein family.|||Interacts with INCA1; the interaction inhibits INCA1 activity and induces the cell cycle process.|||Nucleus http://togogenome.org/gene/9595:SAXO1 ^@ http://purl.uniprot.org/uniprot/G3RYC0 ^@ Similarity ^@ Belongs to the FAM154 family. http://togogenome.org/gene/9595:TRABD2A ^@ http://purl.uniprot.org/uniprot/A0A2I2YXX1|||http://purl.uniprot.org/uniprot/A0A2I2Z6M7|||http://purl.uniprot.org/uniprot/G3QN64 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TIKI family.|||Cell membrane|||Divalent metal cations. Mn(2+) or Co(2+).|||Membrane|||Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. http://togogenome.org/gene/9595:RPL18A ^@ http://purl.uniprot.org/uniprot/G3QK54 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL20 family. http://togogenome.org/gene/9595:RNASE3 ^@ http://purl.uniprot.org/uniprot/P47778 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pancreatic ribonuclease family.|||Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity (By similarity).|||Interacts with bacterial lipopolysaccharide (LPS) and lipoteichoic acid (LTA). In vitro interacts with phospholipid bilayers.|||Secreted http://togogenome.org/gene/9595:TAF1A ^@ http://purl.uniprot.org/uniprot/G3QFT8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits.|||Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.|||Nucleus http://togogenome.org/gene/9595:MFSD4B ^@ http://purl.uniprot.org/uniprot/G3R0E5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:IL20 ^@ http://purl.uniprot.org/uniprot/G3RBT0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/9595:ADAM29 ^@ http://purl.uniprot.org/uniprot/G3R6U2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:SSR4 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZTV2|||http://purl.uniprot.org/uniprot/G3RXH3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-delta family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/9595:ZIC4 ^@ http://purl.uniprot.org/uniprot/G3R0N1 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/9595:ANXA11 ^@ http://purl.uniprot.org/uniprot/G3QST6 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9595:SLC25A47 ^@ http://purl.uniprot.org/uniprot/G3R3T5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9595:PAEP ^@ http://purl.uniprot.org/uniprot/G3QTP4 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9595:FBP2 ^@ http://purl.uniprot.org/uniprot/G3QSB7 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/9595:HSCB ^@ http://purl.uniprot.org/uniprot/G3RLQ2 ^@ Similarity ^@ Belongs to the HscB family. http://togogenome.org/gene/9595:DIPK1B ^@ http://purl.uniprot.org/uniprot/G3RJ05 ^@ Similarity ^@ Belongs to the DIPK family. http://togogenome.org/gene/9595:MLNR ^@ http://purl.uniprot.org/uniprot/G3QMK7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:CLTRN ^@ http://purl.uniprot.org/uniprot/G3SF03 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:GOLGA5 ^@ http://purl.uniprot.org/uniprot/G3SJM4 ^@ Function|||Subcellular Location Annotation ^@ Golgi apparatus membrane|||Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. http://togogenome.org/gene/9595:MANBAL ^@ http://purl.uniprot.org/uniprot/G3S5B6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0239 family.|||Membrane http://togogenome.org/gene/9595:MED22 ^@ http://purl.uniprot.org/uniprot/G3RET4 ^@ Function|||Subcellular Location Annotation ^@ Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/9595:MMP27 ^@ http://purl.uniprot.org/uniprot/G3R045 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9595:PARP1 ^@ http://purl.uniprot.org/uniprot/G3SBV5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARTD/PARP family.|||Chromosome|||Interacts (when auto-poly-ADP-ribosylated) with AIFM1.|||Nucleus|||Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair.|||This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. http://togogenome.org/gene/9595:TBRG1 ^@ http://purl.uniprot.org/uniprot/G3QME3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:DBNDD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y6M9 ^@ Similarity ^@ Belongs to the dysbindin family. http://togogenome.org/gene/9595:ATP6V0A4 ^@ http://purl.uniprot.org/uniprot/G3R0B9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/9595:SCML2 ^@ http://purl.uniprot.org/uniprot/G3RIQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCM family.|||Nucleus http://togogenome.org/gene/9595:RNASEK ^@ http://purl.uniprot.org/uniprot/G3R2T9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase K family.|||Membrane http://togogenome.org/gene/9595:DRP2 ^@ http://purl.uniprot.org/uniprot/G3QNS2 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Perikaryon|||Postsynaptic density|||Required for normal myelination and for normal organization of the cytoplasm and the formation of Cajal bands in myelinating Schwann cells. Required for normal PRX location at appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane. Possibly involved in membrane-cytoskeleton interactions of the central nervous system.|||dendrite http://togogenome.org/gene/9595:GUCA2A ^@ http://purl.uniprot.org/uniprot/G3R796 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylin family.|||Secreted http://togogenome.org/gene/9595:LOC101136823 ^@ http://purl.uniprot.org/uniprot/G3RP05 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/9595:JPT1 ^@ http://purl.uniprot.org/uniprot/G3RDN8|||http://purl.uniprot.org/uniprot/G3RDP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:CCL22 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZUR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9595:IL12A ^@ http://purl.uniprot.org/uniprot/G3QVB8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-6 superfamily.|||Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.|||Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes. As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine. Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites.|||Secreted http://togogenome.org/gene/9595:LOC101148492 ^@ http://purl.uniprot.org/uniprot/G3SBD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:LZTS2 ^@ http://purl.uniprot.org/uniprot/G3RHD5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LZTS2 family.|||Cytoplasm|||Interacts with KATNB1. Also interacts with CTNNB1, gamma-tubulin and KIF23.|||Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.|||centrosome http://togogenome.org/gene/9595:NDRG2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZPJ6|||http://purl.uniprot.org/uniprot/G3QR61 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDRG family.|||Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.|||Cytoplasm http://togogenome.org/gene/9595:TSEN34 ^@ http://purl.uniprot.org/uniprot/G3QYS0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA-intron endonuclease family.|||Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.|||Nucleus http://togogenome.org/gene/9595:ASCC3 ^@ http://purl.uniprot.org/uniprot/G3QJZ8 ^@ Similarity ^@ Belongs to the helicase family. http://togogenome.org/gene/9595:DSTN ^@ http://purl.uniprot.org/uniprot/G3R0W0 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. http://togogenome.org/gene/9595:CCDC47 ^@ http://purl.uniprot.org/uniprot/G3RR28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC47 family.|||Rough endoplasmic reticulum membrane http://togogenome.org/gene/9595:IL17RB ^@ http://purl.uniprot.org/uniprot/G3QHE5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:EDN2 ^@ http://purl.uniprot.org/uniprot/G3RLB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Secreted http://togogenome.org/gene/9595:CRYBB3 ^@ http://purl.uniprot.org/uniprot/G3SCP7 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9595:LOC101135831 ^@ http://purl.uniprot.org/uniprot/G3RRU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ITM2B ^@ http://purl.uniprot.org/uniprot/G3QV34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITM2 family.|||Membrane http://togogenome.org/gene/9595:PITPNM1 ^@ http://purl.uniprot.org/uniprot/G3R3S8 ^@ Similarity ^@ Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily. http://togogenome.org/gene/9595:MAT2B ^@ http://purl.uniprot.org/uniprot/A0A2I2ZDS3|||http://purl.uniprot.org/uniprot/G3S8V1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.|||Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.|||Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. http://togogenome.org/gene/9595:FAM3A ^@ http://purl.uniprot.org/uniprot/A0A2I2Y1L4|||http://purl.uniprot.org/uniprot/A0A2I2ZLG6|||http://purl.uniprot.org/uniprot/G3QRC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/9595:PFKL ^@ http://purl.uniprot.org/uniprot/G3RVJ3 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homo- and heterotetramers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:SLC44A3 ^@ http://purl.uniprot.org/uniprot/G3RDB8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/9595:CD34 ^@ http://purl.uniprot.org/uniprot/G3S916|||http://purl.uniprot.org/uniprot/G3SID7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:HDHD3 ^@ http://purl.uniprot.org/uniprot/G3QVP3 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/9595:TAP2 ^@ http://purl.uniprot.org/uniprot/G3RWW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.|||Membrane http://togogenome.org/gene/9595:FUZ ^@ http://purl.uniprot.org/uniprot/G3R3T1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fuzzy family.|||cytoskeleton http://togogenome.org/gene/9595:SUCLG2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y602 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.|||Binds 1 Mg(2+) ion per subunit.|||GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.|||Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.|||Mitochondrion http://togogenome.org/gene/9595:GOLT1A ^@ http://purl.uniprot.org/uniprot/G3R6G1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||May be involved in fusion of ER-derived transport vesicles with the Golgi complex.|||Membrane http://togogenome.org/gene/9595:UBE2A ^@ http://purl.uniprot.org/uniprot/G3RGA3 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9595:ARRB2 ^@ http://purl.uniprot.org/uniprot/G3QRU2 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9595:ITGA2B ^@ http://purl.uniprot.org/uniprot/G3RAS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9595:CRCP ^@ http://purl.uniprot.org/uniprot/A0A2I2YVB3|||http://purl.uniprot.org/uniprot/A0A2I2ZC64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC9 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/9595:G6PC3 ^@ http://purl.uniprot.org/uniprot/G3R4W9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9595:MTMR12 ^@ http://purl.uniprot.org/uniprot/A0A2I2YTX3 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9595:FBN1 ^@ http://purl.uniprot.org/uniprot/G3QLA9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fibrillin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9595:HOXB5 ^@ http://purl.uniprot.org/uniprot/G3S8F3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9595:AJAP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZN79 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:SLC7A7 ^@ http://purl.uniprot.org/uniprot/G3QM98 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:SKA3 ^@ http://purl.uniprot.org/uniprot/G3REY3|||http://purl.uniprot.org/uniprot/G3S4M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SKA3 family.|||kinetochore|||spindle http://togogenome.org/gene/9595:LOC101127474 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZVX9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. Interacts with RNPS1. Interacts with the SRP receptor subunit SRPRA.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development.|||Cytoplasm|||Endoplasmic reticulum|||Nucleus speckle|||The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.|||The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER. http://togogenome.org/gene/9595:PLA2G4E ^@ http://purl.uniprot.org/uniprot/G3R844 ^@ Domain|||Subcellular Location Annotation ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding.|||cytosol http://togogenome.org/gene/9595:MCMBP ^@ http://purl.uniprot.org/uniprot/G3QT73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCMBP family.|||Nucleus http://togogenome.org/gene/9595:SLC35C1 ^@ http://purl.uniprot.org/uniprot/G3QG59 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:IL1RAPL2 ^@ http://purl.uniprot.org/uniprot/G3QJX3 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9595:CRYBA2 ^@ http://purl.uniprot.org/uniprot/G3R5E7 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9595:DRD2 ^@ http://purl.uniprot.org/uniprot/G3S8W4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:TDP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YJL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosyl-DNA phosphodiesterase family.|||Nucleus http://togogenome.org/gene/9595:SGO2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YSY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shugoshin family.|||centromere http://togogenome.org/gene/9595:LAMC2 ^@ http://purl.uniprot.org/uniprot/G3RF36 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||basement membrane http://togogenome.org/gene/9595:LDHC ^@ http://purl.uniprot.org/uniprot/A0A2I2YN53 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/9595:NDRG4 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y8X7|||http://purl.uniprot.org/uniprot/A0A2I2ZFZ6|||http://purl.uniprot.org/uniprot/G3R275 ^@ Similarity ^@ Belongs to the NDRG family. http://togogenome.org/gene/9595:AGTRAP ^@ http://purl.uniprot.org/uniprot/G3S5X3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:PPM1B ^@ http://purl.uniprot.org/uniprot/A0A2I2Z9I2|||http://purl.uniprot.org/uniprot/G3REP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PP2C family.|||Membrane|||cytosol http://togogenome.org/gene/9595:LOC101132862 ^@ http://purl.uniprot.org/uniprot/G3QV25 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9595:GTF2F1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZFR6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIF alpha subunit family.|||Nucleus|||TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. http://togogenome.org/gene/9595:INKA1 ^@ http://purl.uniprot.org/uniprot/G3R925 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INKA family.|||Nucleus http://togogenome.org/gene/9595:KCNH6 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y2F9|||http://purl.uniprot.org/uniprot/G3RL09 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:C6H6orf58 ^@ http://purl.uniprot.org/uniprot/G3QPL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LEG1 family.|||Secreted http://togogenome.org/gene/9595:JUND ^@ http://purl.uniprot.org/uniprot/G3S843 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. Jun subfamily.|||Nucleus http://togogenome.org/gene/9595:SDC4 ^@ http://purl.uniprot.org/uniprot/G3QNG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane http://togogenome.org/gene/9595:ANXA4 ^@ http://purl.uniprot.org/uniprot/G3QI88 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||Zymogen granule membrane http://togogenome.org/gene/9595:OPA1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y2W8|||http://purl.uniprot.org/uniprot/A0A2I2Y7Q2|||http://purl.uniprot.org/uniprot/G3S1U3 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion inner membrane|||Mitochondrion membrane http://togogenome.org/gene/9595:RPL21 ^@ http://purl.uniprot.org/uniprot/G3QKH6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/9595:CSN1S1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y2L9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-casein family.|||Important role in the capacity of milk to transport calcium phosphate.|||Secreted http://togogenome.org/gene/9595:CD44 ^@ http://purl.uniprot.org/uniprot/A0A2I2YTE1|||http://purl.uniprot.org/uniprot/A0A2I2Z590|||http://purl.uniprot.org/uniprot/A0A2I2ZPR8|||http://purl.uniprot.org/uniprot/G3QEY3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||microvillus http://togogenome.org/gene/9595:ATXN2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z076 ^@ Similarity ^@ Belongs to the ataxin-2 family. http://togogenome.org/gene/9595:CAST ^@ http://purl.uniprot.org/uniprot/A0A2I2YI04|||http://purl.uniprot.org/uniprot/A0A2I2YK81|||http://purl.uniprot.org/uniprot/A0A2I2YMS0|||http://purl.uniprot.org/uniprot/A0A2I2YUD0|||http://purl.uniprot.org/uniprot/A0A2I2Z302|||http://purl.uniprot.org/uniprot/G3R1K6 ^@ Function|||Similarity ^@ Belongs to the protease inhibitor I27 (calpastatin) family.|||Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. http://togogenome.org/gene/9595:SPEM2 ^@ http://purl.uniprot.org/uniprot/G3R821 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:PPP1R2 ^@ http://purl.uniprot.org/uniprot/G3RQX8 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 2 family. http://togogenome.org/gene/9595:CDK2 ^@ http://purl.uniprot.org/uniprot/G3QIR0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:TIGD4 ^@ http://purl.uniprot.org/uniprot/G3R842 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:CFAP45 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y700 ^@ Similarity ^@ Belongs to the CFAP45 family. http://togogenome.org/gene/9595:ITGA8 ^@ http://purl.uniprot.org/uniprot/A0A2I2YGH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9595:GLRA4 ^@ http://purl.uniprot.org/uniprot/G3RDJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/9595:SLC25A3 ^@ http://purl.uniprot.org/uniprot/G3RII8|||http://purl.uniprot.org/uniprot/G3SET8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Interacts with PPIF; the interaction is impaired by CsA.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9595:CPA2 ^@ http://purl.uniprot.org/uniprot/G3QIZ6 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9595:NR2C1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZHL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9595:TDO2 ^@ http://purl.uniprot.org/uniprot/G3RW40 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the tryptophan 2,3-dioxygenase family.|||Binds 1 heme group per subunit.|||Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.|||Homotetramer. Dimer of dimers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:TMEM65 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZLW7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:MZT1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YEM2 ^@ Function|||Similarity ^@ Belongs to the MOZART1 family.|||Required for gamma-tubulin complex recruitment to the centrosome. http://togogenome.org/gene/9595:YWHAZ ^@ http://purl.uniprot.org/uniprot/G3RS45 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9595:GNS ^@ http://purl.uniprot.org/uniprot/G3RH59 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Lysosome|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9595:GASK1B ^@ http://purl.uniprot.org/uniprot/A0A2I2YC52 ^@ Similarity ^@ Belongs to the GASK family. http://togogenome.org/gene/9595:CDK2AP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z8T4|||http://purl.uniprot.org/uniprot/G3R2A0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDK2AP family.|||Nucleus http://togogenome.org/gene/9595:EXOC8 ^@ http://purl.uniprot.org/uniprot/G3S1F3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EXO84 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.|||growth cone|||perinuclear region http://togogenome.org/gene/9595:GHRHR ^@ http://purl.uniprot.org/uniprot/G3QG25 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:BTG4 ^@ http://purl.uniprot.org/uniprot/A0A2I2YKN2 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9595:SCFD2 ^@ http://purl.uniprot.org/uniprot/G3R939 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9595:VSIG1 ^@ http://purl.uniprot.org/uniprot/G3R4U8|||http://purl.uniprot.org/uniprot/G3RZ93 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:CDC37 ^@ http://purl.uniprot.org/uniprot/G3S245 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC37 family.|||Cytoplasm http://togogenome.org/gene/9595:HNRNPK ^@ http://purl.uniprot.org/uniprot/A0A2I2Z071 ^@ Subcellular Location Annotation ^@ Cytoplasm|||nucleoplasm|||podosome http://togogenome.org/gene/9595:CD82 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z3R9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9595:EYA4 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z304|||http://purl.uniprot.org/uniprot/A0A2I2ZPX3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/9595:AFF3 ^@ http://purl.uniprot.org/uniprot/G3SKU4 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/9595:ART1 ^@ http://purl.uniprot.org/uniprot/G3R210 ^@ Similarity ^@ Belongs to the Arg-specific ADP-ribosyltransferase family. http://togogenome.org/gene/9595:CHRDL2 ^@ http://purl.uniprot.org/uniprot/G3SB86 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9595:CA8 ^@ http://purl.uniprot.org/uniprot/G3RXT0 ^@ Similarity ^@ Belongs to the alpha-carbonic anhydrase family. http://togogenome.org/gene/9595:PLXNB2 ^@ http://purl.uniprot.org/uniprot/G3QUT5 ^@ Caution|||Similarity ^@ Belongs to the plexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:FBP1 ^@ http://purl.uniprot.org/uniprot/G3QSC2 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/9595:CTTNBP2 ^@ http://purl.uniprot.org/uniprot/G3RG49 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with CTTN/cortactin SH3 domain. Interacts with STRN, STRN4/zinedin and MOB4/phocein; this interaction may regulate dendritic spine distribution of STRN and STRN4 in hippocampal neurons. Activation of glutamate receptors weakens the interaction with STRN and STRN4.|||Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.|||cell cortex|||dendritic spine http://togogenome.org/gene/9595:NDUFA6 ^@ http://purl.uniprot.org/uniprot/Q0MQA4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Required for proper complex I assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I LYR family.|||Mammalian complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:GPR83 ^@ http://purl.uniprot.org/uniprot/G3QXI1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:CPA1 ^@ http://purl.uniprot.org/uniprot/G3QJ04 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9595:DHPS ^@ http://purl.uniprot.org/uniprot/G3RC40 ^@ Similarity ^@ Belongs to the deoxyhypusine synthase family. http://togogenome.org/gene/9595:CD99 ^@ http://purl.uniprot.org/uniprot/G3R4R1 ^@ Similarity ^@ Belongs to the CD99 family. http://togogenome.org/gene/9595:ARL3 ^@ http://purl.uniprot.org/uniprot/G3SH85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||centrosome http://togogenome.org/gene/9595:BCL7C ^@ http://purl.uniprot.org/uniprot/G3QSJ5 ^@ Similarity ^@ Belongs to the BCL7 family. http://togogenome.org/gene/9595:GSN ^@ http://purl.uniprot.org/uniprot/A0A2I2ZLD6|||http://purl.uniprot.org/uniprot/A0A2I2ZVU1|||http://purl.uniprot.org/uniprot/G3R3X5|||http://purl.uniprot.org/uniprot/G3S1L6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the villin/gelsolin family.|||Binds to actin and to fibronectin. Identified in a complex composed of ACTA1, COBL, GSN and TMSB4X. Interacts with the inactive form of EIF2AK2/PKR.|||Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.|||cytoskeleton http://togogenome.org/gene/9595:PHAF1 ^@ http://purl.uniprot.org/uniprot/G3R884 ^@ Similarity ^@ Belongs to the PHAF1 family. http://togogenome.org/gene/9595:MYH2 ^@ http://purl.uniprot.org/uniprot/G3RN81 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9595:TMEM186 ^@ http://purl.uniprot.org/uniprot/G3R3P2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM186 family.|||Membrane http://togogenome.org/gene/9595:SLC24A4 ^@ http://purl.uniprot.org/uniprot/G3QYN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/9595:LOC101139746 ^@ http://purl.uniprot.org/uniprot/G3REL1 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9595:RNF4 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZC58 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:YTHDC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZW06|||http://purl.uniprot.org/uniprot/G3S4Z8 ^@ Function|||Similarity ^@ Belongs to the YTHDF family.|||Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. http://togogenome.org/gene/9595:PLPP1 ^@ http://purl.uniprot.org/uniprot/G3QHL3|||http://purl.uniprot.org/uniprot/G3RWA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9595:PIK3R1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YFF4|||http://purl.uniprot.org/uniprot/A0A2I2ZF31 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/9595:GLYAT ^@ http://purl.uniprot.org/uniprot/G3QNC8 ^@ Similarity ^@ Belongs to the glycine N-acyltransferase family. http://togogenome.org/gene/9595:SSR3 ^@ http://purl.uniprot.org/uniprot/G3SJT5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-gamma family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/9595:EVA1B ^@ http://purl.uniprot.org/uniprot/G3QVK8 ^@ Similarity ^@ Belongs to the EVA1 family. http://togogenome.org/gene/9595:MYADML2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZF93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAL family.|||Membrane http://togogenome.org/gene/9595:CRISP2 ^@ http://purl.uniprot.org/uniprot/G3S7B6 ^@ Caution|||Similarity ^@ Belongs to the CRISP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:EIF1B ^@ http://purl.uniprot.org/uniprot/G3QZ21 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/9595:PLA1A ^@ http://purl.uniprot.org/uniprot/G3QKJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9595:LOC101134111 ^@ http://purl.uniprot.org/uniprot/G3R9R6 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:HINT2 ^@ http://purl.uniprot.org/uniprot/G3R6M3 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/9595:AK1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YKU8 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK1 subfamily.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/9595:NDUFAF3 ^@ http://purl.uniprot.org/uniprot/G3RBQ0 ^@ Function|||Subcellular Location Annotation ^@ Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).|||Membrane|||Mitochondrion inner membrane|||Nucleus http://togogenome.org/gene/9595:CEBPZ ^@ http://purl.uniprot.org/uniprot/A0A2I2YFX5|||http://purl.uniprot.org/uniprot/G3R6U5 ^@ Similarity ^@ Belongs to the CBF/MAK21 family. http://togogenome.org/gene/9595:SNU13 ^@ http://purl.uniprot.org/uniprot/A0A2I2YHN2|||http://purl.uniprot.org/uniprot/G3S6T9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/9595:STX6 ^@ http://purl.uniprot.org/uniprot/G3QEM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Golgi apparatus membrane http://togogenome.org/gene/9595:ELMO1 ^@ http://purl.uniprot.org/uniprot/G3RL99 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. http://togogenome.org/gene/9595:NUP85 ^@ http://purl.uniprot.org/uniprot/G3QUA0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nucleoporin Nup85 family.|||Component of the nuclear pore complex (NPC).|||Functions as a component of the nuclear pore complex (NPC).|||Nucleus membrane|||nuclear pore complex http://togogenome.org/gene/9595:MRAP ^@ http://purl.uniprot.org/uniprot/G3QDG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRAP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:FAM24A ^@ http://purl.uniprot.org/uniprot/G3QW89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM24 family.|||Secreted http://togogenome.org/gene/9595:NRXN3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZRG5|||http://purl.uniprot.org/uniprot/A0A2I2ZVI8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Presynaptic cell membrane http://togogenome.org/gene/9595:PXMP4 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y5V8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Interacts with PEX19.|||Peroxisome membrane http://togogenome.org/gene/9595:PRL ^@ http://purl.uniprot.org/uniprot/G3QG92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Secreted http://togogenome.org/gene/9595:ARV1 ^@ http://purl.uniprot.org/uniprot/G3S847 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARV1 family.|||Endoplasmic reticulum membrane|||Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.|||Membrane http://togogenome.org/gene/9595:PABPC3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZA10 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyadenylate-binding protein type-1 family.|||Binds the poly(A) tail of mRNA.|||Cytoplasm http://togogenome.org/gene/9595:GLRB ^@ http://purl.uniprot.org/uniprot/G3S3Z3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane http://togogenome.org/gene/9595:ETFDH ^@ http://purl.uniprot.org/uniprot/G3S2H8 ^@ Cofactor|||Function ^@ Accepts electrons from ETF and reduces ubiquinone.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/9595:SNAP47 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1Y1|||http://purl.uniprot.org/uniprot/G3QZE5 ^@ Similarity ^@ Belongs to the SVAP1 family. http://togogenome.org/gene/9595:ASAH1 ^@ http://purl.uniprot.org/uniprot/G3RZ91 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acid ceramidase family.|||Heterodimer.|||Lysosome http://togogenome.org/gene/9595:CTNNA3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZCF0 ^@ Similarity ^@ Belongs to the vinculin/alpha-catenin family. http://togogenome.org/gene/9595:LOC101145021 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z715 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:AKAP5 ^@ http://purl.uniprot.org/uniprot/G3SEG4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:CEBPD ^@ http://purl.uniprot.org/uniprot/G3QYG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. C/EBP subfamily.|||Nucleus http://togogenome.org/gene/9595:UTP11 ^@ http://purl.uniprot.org/uniprot/A0A2I2YQU7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UTP11 family.|||Component of the ribosomal small subunit (SSU) processome.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/9595:RNF39 ^@ http://purl.uniprot.org/uniprot/G3RPQ0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:PRPH2 ^@ http://purl.uniprot.org/uniprot/G3QNA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRPH2/ROM1 family.|||Membrane http://togogenome.org/gene/9595:PTMA ^@ http://purl.uniprot.org/uniprot/A0A2I2ZUW0 ^@ Similarity ^@ Belongs to the pro/parathymosin family. http://togogenome.org/gene/9595:NR2E1 ^@ http://purl.uniprot.org/uniprot/G3RWA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9595:FPR1 ^@ http://purl.uniprot.org/uniprot/G3QRA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:PSD ^@ http://purl.uniprot.org/uniprot/G3QVQ5 ^@ Subcellular Location Annotation ^@ Membrane|||ruffle membrane http://togogenome.org/gene/9595:MYCBP ^@ http://purl.uniprot.org/uniprot/G3QSP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AMY1 family.|||Nucleus http://togogenome.org/gene/9595:TPST1 ^@ http://purl.uniprot.org/uniprot/G3RXV8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein sulfotransferase family.|||Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.|||Golgi apparatus membrane http://togogenome.org/gene/9595:GPRC5A ^@ http://purl.uniprot.org/uniprot/G3RIM0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:TEK ^@ http://purl.uniprot.org/uniprot/G3RIN5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:GALK2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YIZ2 ^@ Similarity ^@ Belongs to the GHMP kinase family. GalK subfamily. http://togogenome.org/gene/9595:CAMK2N1 ^@ http://purl.uniprot.org/uniprot/G3QUX8 ^@ Similarity ^@ Belongs to the CAMK2N family. http://togogenome.org/gene/9595:LOC101147253 ^@ http://purl.uniprot.org/uniprot/G3SIR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase VIIb family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9595:LTV1 ^@ http://purl.uniprot.org/uniprot/G3SJE5 ^@ Similarity ^@ Belongs to the LTV1 family. http://togogenome.org/gene/9595:FOXN2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YXV7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:MFAP2 ^@ http://purl.uniprot.org/uniprot/G3RJF4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MFAP family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9595:LOC101125335 ^@ http://purl.uniprot.org/uniprot/G3QP21 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. http://togogenome.org/gene/9595:PHF5A ^@ http://purl.uniprot.org/uniprot/G3QFL1 ^@ Similarity ^@ Belongs to the PHF5 family. http://togogenome.org/gene/9595:HUS1B ^@ http://purl.uniprot.org/uniprot/G3QWT6 ^@ Similarity ^@ Belongs to the HUS1 family. http://togogenome.org/gene/9595:PDCL ^@ http://purl.uniprot.org/uniprot/G3RC41 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9595:ESRRA ^@ http://purl.uniprot.org/uniprot/G3QG65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/9595:GPR101 ^@ http://purl.uniprot.org/uniprot/G3QRA2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:FAM3B ^@ http://purl.uniprot.org/uniprot/A0A2I2ZCK4|||http://purl.uniprot.org/uniprot/G3SA99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/9595:NIFK ^@ http://purl.uniprot.org/uniprot/G3RQP7 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9595:CHRNA1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZA95|||http://purl.uniprot.org/uniprot/G3S4U7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9595:STC1 ^@ http://purl.uniprot.org/uniprot/G3SGP0 ^@ Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9595:TP53INP2 ^@ http://purl.uniprot.org/uniprot/G3S6E0 ^@ Subcellular Location Annotation ^@ PML body|||autophagosome|||cytosol http://togogenome.org/gene/9595:LOC101151965 ^@ http://purl.uniprot.org/uniprot/G3QCV6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9595:ATP1A4 ^@ http://purl.uniprot.org/uniprot/G3RB63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:MPHOSPH10 ^@ http://purl.uniprot.org/uniprot/G3QMT7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MPP10 family.|||Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.|||nucleolus http://togogenome.org/gene/9595:GIMAP6 ^@ http://purl.uniprot.org/uniprot/G3QEB2 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9595:PDGFD ^@ http://purl.uniprot.org/uniprot/G3QI67 ^@ Caution|||Similarity ^@ Belongs to the PDGF/VEGF growth factor family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:HSPA1L ^@ http://purl.uniprot.org/uniprot/G3S9G1 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9595:APOA4 ^@ http://purl.uniprot.org/uniprot/G3S2R4 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/9595:MAPK4 ^@ http://purl.uniprot.org/uniprot/G3RXT3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9595:TNR ^@ http://purl.uniprot.org/uniprot/G3RJQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tenascin family.|||extracellular matrix http://togogenome.org/gene/9595:DYDC2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZUC6|||http://purl.uniprot.org/uniprot/G3QMF0 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/9595:LOC101129166 ^@ http://purl.uniprot.org/uniprot/G3RKB0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9595:TMEM38B ^@ http://purl.uniprot.org/uniprot/A0A2I2YFB8|||http://purl.uniprot.org/uniprot/G3QWA3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM38 family.|||Membrane|||Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. http://togogenome.org/gene/9595:DPY19L3 ^@ http://purl.uniprot.org/uniprot/G3R1A4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dpy-19 family.|||Membrane|||Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. http://togogenome.org/gene/9595:CPNE8 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y4M4 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9595:IL25 ^@ http://purl.uniprot.org/uniprot/A0A2I2YV12 ^@ Similarity ^@ Belongs to the IL-17 family. http://togogenome.org/gene/9595:CCN3 ^@ http://purl.uniprot.org/uniprot/G3QJX6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9595:LOC101154090 ^@ http://purl.uniprot.org/uniprot/A0A2I2YYX3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:TMEM115 ^@ http://purl.uniprot.org/uniprot/G3QW27 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:UFD1 ^@ http://purl.uniprot.org/uniprot/G3QNC2 ^@ Similarity ^@ Belongs to the UFD1 family. http://togogenome.org/gene/9595:HS6ST2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z9A8|||http://purl.uniprot.org/uniprot/G3RE22 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.|||Belongs to the sulfotransferase 6 family.|||Membrane http://togogenome.org/gene/9595:ARF5 ^@ http://purl.uniprot.org/uniprot/G3RKR2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/9595:CBX2 ^@ http://purl.uniprot.org/uniprot/G3R2W1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:AIMP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YMA9 ^@ Subcellular Location Annotation ^@ Nucleus|||cytosol http://togogenome.org/gene/9595:TMOD2 ^@ http://purl.uniprot.org/uniprot/G3RI10 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9595:PRC1 ^@ http://purl.uniprot.org/uniprot/G3QZ43|||http://purl.uniprot.org/uniprot/G3S6K8 ^@ Similarity ^@ Belongs to the MAP65/ASE1 family. http://togogenome.org/gene/9595:CPNE4 ^@ http://purl.uniprot.org/uniprot/G3R6B4 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9595:VPS37D ^@ http://purl.uniprot.org/uniprot/G3QGH6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9595:HPSE ^@ http://purl.uniprot.org/uniprot/G3RPR9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 79 family. http://togogenome.org/gene/9595:NOL11 ^@ http://purl.uniprot.org/uniprot/G3RPK8 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9595:ADCY6 ^@ http://purl.uniprot.org/uniprot/G3QIR6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/9595:TGM7 ^@ http://purl.uniprot.org/uniprot/G3QXA4 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9595:TATDN3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZVJ7|||http://purl.uniprot.org/uniprot/G3S006 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. http://togogenome.org/gene/9595:CCBE1 ^@ http://purl.uniprot.org/uniprot/G3RJV0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:HEXD ^@ http://purl.uniprot.org/uniprot/G3S931 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 20 family. http://togogenome.org/gene/9595:TFB2M ^@ http://purl.uniprot.org/uniprot/G3QFK2 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:CLDN7 ^@ http://purl.uniprot.org/uniprot/G3SJL4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9595:ACTR8 ^@ http://purl.uniprot.org/uniprot/G3QEH4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the actin family. ARP8 subfamily.|||Chromosome|||Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core.|||Nucleus|||Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.|||Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. http://togogenome.org/gene/9595:ISCA2 ^@ http://purl.uniprot.org/uniprot/G3SGX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HesB/IscA family.|||Mitochondrion http://togogenome.org/gene/9595:SLC45A1 ^@ http://purl.uniprot.org/uniprot/G3RF31 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:YARS1 ^@ http://purl.uniprot.org/uniprot/G3RDR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Nucleus http://togogenome.org/gene/9595:LIFR ^@ http://purl.uniprot.org/uniprot/G3RGA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/9595:CHPF ^@ http://purl.uniprot.org/uniprot/G3QJT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9595:GNRH1 ^@ http://purl.uniprot.org/uniprot/G3QPA2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GnRH family.|||Secreted|||Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones. http://togogenome.org/gene/9595:KCNS1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YND0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:PRKAA2 ^@ http://purl.uniprot.org/uniprot/G3R126 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:RNASE1 ^@ http://purl.uniprot.org/uniprot/Q8SQ13 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pancreatic ribonuclease family.|||Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA (By similarity).|||Monomer. Interacts with and forms tight 1:1 complexes with RNH1. Dimerization of two such complexes may occur. Interaction with RNH1 inhibits this protein (By similarity).|||Secreted http://togogenome.org/gene/9595:CYLD ^@ http://purl.uniprot.org/uniprot/G3S7H6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||centrosome|||cilium basal body|||perinuclear region|||spindle http://togogenome.org/gene/9595:PTPN18 ^@ http://purl.uniprot.org/uniprot/G3RK73 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. http://togogenome.org/gene/9595:LOC101141577 ^@ http://purl.uniprot.org/uniprot/G3QMM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:STAC ^@ http://purl.uniprot.org/uniprot/G3RCH3 ^@ Subcellular Location Annotation ^@ sarcolemma http://togogenome.org/gene/9595:ALDOC ^@ http://purl.uniprot.org/uniprot/G3R2M4 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/9595:MRPS31 ^@ http://purl.uniprot.org/uniprot/G3QUC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS31 family.|||Mitochondrion http://togogenome.org/gene/9595:NELL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZNJ6|||http://purl.uniprot.org/uniprot/G3SKE2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:CORO1B ^@ http://purl.uniprot.org/uniprot/G3R3E7 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/9595:ARPC2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZVL5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC2 family.|||Cell projection|||Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton|||synaptosome http://togogenome.org/gene/9595:EDEM3 ^@ http://purl.uniprot.org/uniprot/G3QK44 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9595:IPO4 ^@ http://purl.uniprot.org/uniprot/G3S5I6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:SRFBP1 ^@ http://purl.uniprot.org/uniprot/G3QXL0 ^@ Function|||Subunit ^@ Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4.|||May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells. http://togogenome.org/gene/9595:LOC101137794 ^@ http://purl.uniprot.org/uniprot/G3QKJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ESX1 ^@ http://purl.uniprot.org/uniprot/G3QMI0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:WNT10A ^@ http://purl.uniprot.org/uniprot/G3QEZ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9595:HOXA3 ^@ http://purl.uniprot.org/uniprot/G3QIG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9595:ENTPD3 ^@ http://purl.uniprot.org/uniprot/G3QQQ1 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9595:ZNF408 ^@ http://purl.uniprot.org/uniprot/G3R3S5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:EPO ^@ http://purl.uniprot.org/uniprot/G3RS27 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPO/TPO family.|||Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.|||Secreted http://togogenome.org/gene/9595:GORASP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YV97|||http://purl.uniprot.org/uniprot/G3S3A1 ^@ Similarity ^@ Belongs to the GORASP family. http://togogenome.org/gene/9595:SPACA3 ^@ http://purl.uniprot.org/uniprot/G3QFN2|||http://purl.uniprot.org/uniprot/G3RQ54 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9595:ALPI ^@ http://purl.uniprot.org/uniprot/G3RWG5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alkaline phosphatase family.|||Binds 1 Mg(2+) ion.|||Binds 2 Zn(2+) ions.|||Cell membrane|||Homodimer.|||Membrane http://togogenome.org/gene/9595:LOXHD1 ^@ http://purl.uniprot.org/uniprot/G3SGV7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:RNF5 ^@ http://purl.uniprot.org/uniprot/G3RQU7 ^@ Domain|||Function|||Subcellular Location Annotation ^@ E3 ubiquitin-protein ligase.|||Endoplasmic reticulum membrane|||Mitochondrion membrane|||The RING-type zinc finger domain is responsible for E3 ligase activity. http://togogenome.org/gene/9595:GLUD1 ^@ http://purl.uniprot.org/uniprot/G3RI93 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/9595:UBE2U ^@ http://purl.uniprot.org/uniprot/G3QGK2 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9595:PTPRN ^@ http://purl.uniprot.org/uniprot/A0A2I2ZUY9|||http://purl.uniprot.org/uniprot/G3R874 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.|||Membrane|||secretory vesicle membrane http://togogenome.org/gene/9595:DUSP2 ^@ http://purl.uniprot.org/uniprot/G3R650 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/9595:TAF5L ^@ http://purl.uniprot.org/uniprot/G3RRZ6 ^@ Similarity ^@ Belongs to the WD repeat TAF5 family. http://togogenome.org/gene/9595:RXRG ^@ http://purl.uniprot.org/uniprot/G3S7Z4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.|||Homodimer. Heterodimer; with a rar molecule.|||Nucleus|||Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. http://togogenome.org/gene/9595:ADGRA1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y4D5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:ENTR1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YCA3|||http://purl.uniprot.org/uniprot/A0A2I2ZUW8|||http://purl.uniprot.org/uniprot/G3R5Q0 ^@ Similarity ^@ Belongs to the ENTR1 family. http://togogenome.org/gene/9595:MGST2 ^@ http://purl.uniprot.org/uniprot/G3QQL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:LOC101141336 ^@ http://purl.uniprot.org/uniprot/G3RDV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:SKAP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1F9|||http://purl.uniprot.org/uniprot/G3QIB0 ^@ Similarity ^@ Belongs to the SKAP family. http://togogenome.org/gene/9595:VPS28 ^@ http://purl.uniprot.org/uniprot/G3SD56 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS28 family.|||Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.|||Membrane http://togogenome.org/gene/9595:ZDHHC16 ^@ http://purl.uniprot.org/uniprot/A0A2I2YFV3|||http://purl.uniprot.org/uniprot/A0A2I2Z4U9|||http://purl.uniprot.org/uniprot/A0A2I2ZX16 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9595:CCHCR1 ^@ http://purl.uniprot.org/uniprot/G3R6G3 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be a regulator of keratinocyte proliferation or differentiation.|||Nucleus http://togogenome.org/gene/9595:ARF1 ^@ http://purl.uniprot.org/uniprot/G3R6M1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/9595:KCNH7 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZMI5|||http://purl.uniprot.org/uniprot/A0A2I2ZQ14 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:RAB3A ^@ http://purl.uniprot.org/uniprot/G3RE65 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/9595:SOAT1 ^@ http://purl.uniprot.org/uniprot/G3S252|||http://purl.uniprot.org/uniprot/G3S4J8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:ZNF687 ^@ http://purl.uniprot.org/uniprot/G3RGM9 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9595:HAMP ^@ http://purl.uniprot.org/uniprot/G3QEQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hepcidin family.|||Secreted http://togogenome.org/gene/9595:BICC1 ^@ http://purl.uniprot.org/uniprot/G3QRW0 ^@ Similarity ^@ Belongs to the BicC family. http://togogenome.org/gene/9595:TIGD7 ^@ http://purl.uniprot.org/uniprot/G3R4K8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:APOL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZQF1 ^@ Similarity ^@ Belongs to the apolipoprotein L family. http://togogenome.org/gene/9595:ZFP36L1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZGR6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.|||Cytoplasm|||Nucleus|||Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. http://togogenome.org/gene/9595:PGF ^@ http://purl.uniprot.org/uniprot/G3SE83 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/9595:CCDC181 ^@ http://purl.uniprot.org/uniprot/A0A2I2YQN5|||http://purl.uniprot.org/uniprot/G3SDR3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC181 family.|||Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.|||cytoskeleton|||flagellum http://togogenome.org/gene/9595:PLBD1 ^@ http://purl.uniprot.org/uniprot/G3R7A2 ^@ Function|||Similarity ^@ Belongs to the phospholipase B-like family.|||Putative phospholipase. http://togogenome.org/gene/9595:OSMR ^@ http://purl.uniprot.org/uniprot/G3RF68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/9595:TBX5 ^@ http://purl.uniprot.org/uniprot/G3RD44 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9595:ABCB1 ^@ http://purl.uniprot.org/uniprot/G3S959 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:LOC101144032 ^@ http://purl.uniprot.org/uniprot/G3R5A0 ^@ Similarity ^@ Belongs to the cytochrome c oxidase VIIa family. http://togogenome.org/gene/9595:PTPN13 ^@ http://purl.uniprot.org/uniprot/G3RM63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||cytoskeleton http://togogenome.org/gene/9595:FNIP2 ^@ http://purl.uniprot.org/uniprot/G3S532 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNIP family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9595:FAM174B ^@ http://purl.uniprot.org/uniprot/G3QRM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM174 family.|||Membrane http://togogenome.org/gene/9595:PLK2 ^@ http://purl.uniprot.org/uniprot/G3RAD3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. http://togogenome.org/gene/9595:LOC101149901 ^@ http://purl.uniprot.org/uniprot/G3R0E9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ANAPC10 ^@ http://purl.uniprot.org/uniprot/G3S5D3 ^@ Function|||Similarity ^@ Belongs to the APC10 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. http://togogenome.org/gene/9595:FLVCR2 ^@ http://purl.uniprot.org/uniprot/G3RS74 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:TMEM9B ^@ http://purl.uniprot.org/uniprot/G3QXS7 ^@ Similarity ^@ Belongs to the TMEM9 family. http://togogenome.org/gene/9595:ARHGEF6 ^@ http://purl.uniprot.org/uniprot/G3RDP0 ^@ Subcellular Location Annotation ^@ lamellipodium http://togogenome.org/gene/9595:ENTPD2 ^@ http://purl.uniprot.org/uniprot/G3R7S8 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9595:CDA ^@ http://purl.uniprot.org/uniprot/G3QN51 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/9595:SPOCK3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZGC3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:VPS33B ^@ http://purl.uniprot.org/uniprot/A0A2I2ZMS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STXBP/unc-18/SEC1 family.|||Early endosome|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||clathrin-coated vesicle http://togogenome.org/gene/9595:LARS2 ^@ http://purl.uniprot.org/uniprot/G3RI94 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9595:ALG11 ^@ http://purl.uniprot.org/uniprot/G3SAS3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.|||Endoplasmic reticulum membrane|||Required for N-linked oligosaccharide assembly. http://togogenome.org/gene/9595:KPNA1 ^@ http://purl.uniprot.org/uniprot/G3RIQ5 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9595:SUMO1 ^@ http://purl.uniprot.org/uniprot/G3S6X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin family. SUMO subfamily.|||Nucleus http://togogenome.org/gene/9595:PROM1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YA46|||http://purl.uniprot.org/uniprot/G3S7V7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prominin family.|||Membrane|||microvillus membrane http://togogenome.org/gene/9595:AP1G1 ^@ http://purl.uniprot.org/uniprot/G3RVE5 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/9595:CXXC5 ^@ http://purl.uniprot.org/uniprot/G3RE56 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:NPY5R ^@ http://purl.uniprot.org/uniprot/G3QP85 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders. http://togogenome.org/gene/9595:SUCLA2 ^@ http://purl.uniprot.org/uniprot/G3QYU7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.|||Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.|||Mitochondrion http://togogenome.org/gene/9595:SMAD1 ^@ http://purl.uniprot.org/uniprot/G3SBY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:GABRB1 ^@ http://purl.uniprot.org/uniprot/G3SKE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9595:CEBPG ^@ http://purl.uniprot.org/uniprot/A0A2I2ZAY5 ^@ Similarity ^@ Belongs to the bZIP family. C/EBP subfamily. http://togogenome.org/gene/9595:THBS4 ^@ http://purl.uniprot.org/uniprot/G3SD95 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:SUPV3L1 ^@ http://purl.uniprot.org/uniprot/G3QRG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family.|||mitochondrion nucleoid http://togogenome.org/gene/9595:NUP93 ^@ http://purl.uniprot.org/uniprot/G3R3M2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin interacting component (NIC) family.|||Nucleus membrane|||Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.|||nuclear pore complex http://togogenome.org/gene/9595:POP5 ^@ http://purl.uniprot.org/uniprot/G3RCE3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family.|||Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.|||nucleolus http://togogenome.org/gene/9595:FADS6 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y9U1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:FGF7 ^@ http://purl.uniprot.org/uniprot/G3QRL0 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9595:MRPL44 ^@ http://purl.uniprot.org/uniprot/G3RE81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.|||Mitochondrion http://togogenome.org/gene/9595:CALHM6 ^@ http://purl.uniprot.org/uniprot/G3QGA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9595:IFI44L ^@ http://purl.uniprot.org/uniprot/G3RCT4 ^@ Similarity ^@ Belongs to the IFI44 family. http://togogenome.org/gene/9595:LOC101133285 ^@ http://purl.uniprot.org/uniprot/G3RR03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 6A family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9595:NUMB ^@ http://purl.uniprot.org/uniprot/A0A2I2YDF7|||http://purl.uniprot.org/uniprot/A0A2I2ZY37|||http://purl.uniprot.org/uniprot/G3QIA3 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Plays a role in the process of neurogenesis. http://togogenome.org/gene/9595:TMEM151A ^@ http://purl.uniprot.org/uniprot/G3R2T2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM151 family.|||Membrane http://togogenome.org/gene/9595:FAM98C ^@ http://purl.uniprot.org/uniprot/G3SA68 ^@ Similarity ^@ Belongs to the FAM98 family. http://togogenome.org/gene/9595:HSD17B10 ^@ http://purl.uniprot.org/uniprot/G3RYQ4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9595:USP3 ^@ http://purl.uniprot.org/uniprot/G3SG64 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9595:LOC101135098 ^@ http://purl.uniprot.org/uniprot/A0A2I2YG23 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:MLLT11 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y341 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MLLT11 family.|||Nucleus|||centrosome http://togogenome.org/gene/9595:MRPL47 ^@ http://purl.uniprot.org/uniprot/G3RSK8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/9595:EEIG2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZIZ1 ^@ Similarity ^@ Belongs to the EEIG family. http://togogenome.org/gene/9595:UBAP2 ^@ http://purl.uniprot.org/uniprot/G3RBZ1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:ADIPOR2 ^@ http://purl.uniprot.org/uniprot/G3RDI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9595:WDR55 ^@ http://purl.uniprot.org/uniprot/G3RC37 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR55 family.|||Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis.|||nucleolus http://togogenome.org/gene/9595:SLC45A3 ^@ http://purl.uniprot.org/uniprot/G3QUX3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:GABARAPL2 ^@ http://purl.uniprot.org/uniprot/G3R9C1 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9595:CNIH1 ^@ http://purl.uniprot.org/uniprot/G3RBT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/9595:BRINP3 ^@ http://purl.uniprot.org/uniprot/G3QZJ0 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/9595:LOC101148074 ^@ http://purl.uniprot.org/uniprot/G3QQ88 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9595:TM4SF4 ^@ http://purl.uniprot.org/uniprot/G3QHI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9595:CHST12 ^@ http://purl.uniprot.org/uniprot/G3RIC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:GAA ^@ http://purl.uniprot.org/uniprot/G3RAW5 ^@ Caution|||Similarity ^@ Belongs to the glycosyl hydrolase 31 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:HNRNPA3 ^@ http://purl.uniprot.org/uniprot/G3QTH6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:MANBA ^@ http://purl.uniprot.org/uniprot/G3R2R2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 2 family.|||Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.|||Lysosome|||Monomer. http://togogenome.org/gene/9595:ACAD10 ^@ http://purl.uniprot.org/uniprot/G3SC08 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9595:SLC25A45 ^@ http://purl.uniprot.org/uniprot/A0A2I2YQ03|||http://purl.uniprot.org/uniprot/A0A2I2Z1P3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9595:FERMT1 ^@ http://purl.uniprot.org/uniprot/G3RD95 ^@ Similarity ^@ Belongs to the kindlin family. http://togogenome.org/gene/9595:ENKD1 ^@ http://purl.uniprot.org/uniprot/G3QMS2 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9595:NDUFB3 ^@ http://purl.uniprot.org/uniprot/Q0MQD1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB3 subunit family.|||Complex I is composed of 45 different subunits.|||Methylation at His residues by METTL9 enhances complex I-mediated mitochondrial respiration.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:LOC101144277 ^@ http://purl.uniprot.org/uniprot/Q8SQ79 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIII family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:TRAPPC13 ^@ http://purl.uniprot.org/uniprot/G3RHF6|||http://purl.uniprot.org/uniprot/G3RMQ9 ^@ Similarity|||Subunit ^@ Belongs to the TRAPPC13 family.|||Part of the multisubunit TRAPP (transport protein particle) complex. http://togogenome.org/gene/9595:ERG28 ^@ http://purl.uniprot.org/uniprot/G3QUF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG28 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:LOC101152583 ^@ http://purl.uniprot.org/uniprot/A0A2I2YSB4 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:TSPAN13 ^@ http://purl.uniprot.org/uniprot/G3R6D5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9595:CPT1B ^@ http://purl.uniprot.org/uniprot/G3QS89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the carnitine/choline acetyltransferase family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9595:STX7 ^@ http://purl.uniprot.org/uniprot/G3QNE2 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9595:MSH5 ^@ http://purl.uniprot.org/uniprot/A0A2I2YSF4 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutS family. http://togogenome.org/gene/9595:TNFSF11 ^@ http://purl.uniprot.org/uniprot/G3R6F7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Homotrimer.|||Membrane|||Secreted http://togogenome.org/gene/9595:OVCH2 ^@ http://purl.uniprot.org/uniprot/G3S926 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:HOGA1 ^@ http://purl.uniprot.org/uniprot/G3RGV3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the final step in the metabolic pathway of hydroxyproline.|||Homotetramer. http://togogenome.org/gene/9595:SH3BP5L ^@ http://purl.uniprot.org/uniprot/G3R123 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SH3BP5 family.|||Cytoplasm|||Functions as guanine nucleotide exchange factor (GEF) for RAB11A.|||Interacts with GDP-bound and nucleotide-free forms of RAB11A.|||The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape. http://togogenome.org/gene/9595:APEX1 ^@ http://purl.uniprot.org/uniprot/G3QI91 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Cytoplasm|||Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.|||Mitochondrion|||Nucleus|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/9595:GDA ^@ http://purl.uniprot.org/uniprot/A0A2I2Y4Z7|||http://purl.uniprot.org/uniprot/G3QZN7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.|||Binds 1 zinc ion per subunit.|||Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. http://togogenome.org/gene/9595:POLR3D ^@ http://purl.uniprot.org/uniprot/G3QWI8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:BRK1 ^@ http://purl.uniprot.org/uniprot/G3RZT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BRK1 family.|||cytoskeleton http://togogenome.org/gene/9595:RBM10 ^@ http://purl.uniprot.org/uniprot/G3QXY4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:ZC3HAV1 ^@ http://purl.uniprot.org/uniprot/G3QEF0 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9595:A2ML1 ^@ http://purl.uniprot.org/uniprot/G3QPP3|||http://purl.uniprot.org/uniprot/G3SA75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.|||Secreted http://togogenome.org/gene/9595:THYN1 ^@ http://purl.uniprot.org/uniprot/G3QV97 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. http://togogenome.org/gene/9595:B3GALNT2 ^@ http://purl.uniprot.org/uniprot/G3RCS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:CRYL1 ^@ http://purl.uniprot.org/uniprot/G3R639 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/9595:SMPD1 ^@ http://purl.uniprot.org/uniprot/G3QI84 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acid sphingomyelinase family.|||Binds 2 Zn(2+) ions per subunit.|||Converts sphingomyelin to ceramide.|||Secreted http://togogenome.org/gene/9595:KCNE3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y3G9 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/9595:TSPAN11 ^@ http://purl.uniprot.org/uniprot/G3QXD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9595:FAM83D ^@ http://purl.uniprot.org/uniprot/G3RI11 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9595:BRS3 ^@ http://purl.uniprot.org/uniprot/G3QL90 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with C6orf89.|||Membrane http://togogenome.org/gene/9595:BTD ^@ http://purl.uniprot.org/uniprot/G3RR06 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. http://togogenome.org/gene/9595:CTH ^@ http://purl.uniprot.org/uniprot/G3RK81 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/9595:SCGB1C1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z0Y6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the secretoglobin family.|||Secreted http://togogenome.org/gene/9595:LOC101153360 ^@ http://purl.uniprot.org/uniprot/G3SD53 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MHC class I family.|||Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).|||Involved in the presentation of foreign antigens to the immune system. http://togogenome.org/gene/9595:HSP90B1 ^@ http://purl.uniprot.org/uniprot/G3QHR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 90 family.|||Melanosome http://togogenome.org/gene/9595:SLC29A2 ^@ http://purl.uniprot.org/uniprot/G3QYC7 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Basolateral cell membrane|||Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9595:LOC101126380 ^@ http://purl.uniprot.org/uniprot/G3REL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:MPDU1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YM40|||http://purl.uniprot.org/uniprot/G3SDB4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MPDU1 (TC 2.A.43.3) family.|||Membrane|||Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors. http://togogenome.org/gene/9595:GTF2A1L ^@ http://purl.uniprot.org/uniprot/G3SHY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 1 family.|||Nucleus http://togogenome.org/gene/9595:OCIAD1 ^@ http://purl.uniprot.org/uniprot/G3QUW6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OCIAD1 family.|||Endosome|||Interacts with STAT3.|||Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.|||The OCIA domain is necessary and sufficient for endosomal localization. http://togogenome.org/gene/9595:UBN1 ^@ http://purl.uniprot.org/uniprot/G3R9Y9 ^@ Similarity ^@ Belongs to the ubinuclein family. http://togogenome.org/gene/9595:EPC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YFP3|||http://purl.uniprot.org/uniprot/G3QYH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enhancer of polycomb family.|||Nucleus http://togogenome.org/gene/9595:EIF1AX ^@ http://purl.uniprot.org/uniprot/G3S0P1 ^@ Function|||Similarity ^@ Belongs to the eIF-1A family.|||Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. http://togogenome.org/gene/9595:BUD23 ^@ http://purl.uniprot.org/uniprot/G3QGH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:DDIT4 ^@ http://purl.uniprot.org/uniprot/G3QJW5 ^@ Similarity ^@ Belongs to the DDIT4 family. http://togogenome.org/gene/9595:CDADC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YRN3|||http://purl.uniprot.org/uniprot/G3QR52 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/9595:CPE ^@ http://purl.uniprot.org/uniprot/G3S2F1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M14 family.|||Interacts with Secretogranin III/SCG3.|||Membrane|||Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage.|||secretory vesicle membrane http://togogenome.org/gene/9595:PSMA4 ^@ http://purl.uniprot.org/uniprot/G3QD78 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9595:PDK3 ^@ http://purl.uniprot.org/uniprot/G3SE87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9595:KCNJ10 ^@ http://purl.uniprot.org/uniprot/G3S8U4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9595:CAPN6 ^@ http://purl.uniprot.org/uniprot/G3QXW3 ^@ Caution|||Similarity ^@ Belongs to the peptidase C2 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:SLC39A5 ^@ http://purl.uniprot.org/uniprot/G3R109 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:HOXB8 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z3F0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:CCND2 ^@ http://purl.uniprot.org/uniprot/G3R223 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9595:DPM1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZNK7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum|||Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex. http://togogenome.org/gene/9595:TMPRSS11F ^@ http://purl.uniprot.org/uniprot/G3QFZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Membrane http://togogenome.org/gene/9595:PPM1L ^@ http://purl.uniprot.org/uniprot/A0A2I2YNX0 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9595:UCN3 ^@ http://purl.uniprot.org/uniprot/G3RKW1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Binds with high affinity to CRF receptors 2-alpha and 2-beta.|||Secreted|||Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. http://togogenome.org/gene/9595:METTL16 ^@ http://purl.uniprot.org/uniprot/G3R2P8 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METTL16/RlmF family.|||RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. http://togogenome.org/gene/9595:POU4F3 ^@ http://purl.uniprot.org/uniprot/G3R9P3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/9595:ARHGEF11 ^@ http://purl.uniprot.org/uniprot/G3RG84|||http://purl.uniprot.org/uniprot/G3SDF2 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Membrane http://togogenome.org/gene/9595:PRDX2 ^@ http://purl.uniprot.org/uniprot/G3S156 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/9595:CHDH ^@ http://purl.uniprot.org/uniprot/G3QGJ5 ^@ Similarity ^@ Belongs to the GMC oxidoreductase family. http://togogenome.org/gene/9595:ERBIN ^@ http://purl.uniprot.org/uniprot/A0A2I2YC48|||http://purl.uniprot.org/uniprot/A0A2I2YNW1|||http://purl.uniprot.org/uniprot/G3QWC1|||http://purl.uniprot.org/uniprot/G3S7K4 ^@ Similarity ^@ Belongs to the LAP (LRR and PDZ) protein family. http://togogenome.org/gene/9595:OSTC ^@ http://purl.uniprot.org/uniprot/G3RSE5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OSTC family.|||Component of the oligosaccharyltransferase (OST) complex.|||Membrane|||Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1. http://togogenome.org/gene/9595:PRDX6 ^@ http://purl.uniprot.org/uniprot/G3S6S1 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/9595:RANGRF ^@ http://purl.uniprot.org/uniprot/G3R667 ^@ Similarity ^@ Belongs to the MOG1 family. http://togogenome.org/gene/9595:ZKSCAN5 ^@ http://purl.uniprot.org/uniprot/G3R289 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:APLP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z327 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APP family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:NPC1L1 ^@ http://purl.uniprot.org/uniprot/G3S1S8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the patched family.|||Membrane http://togogenome.org/gene/9595:PTER ^@ http://purl.uniprot.org/uniprot/G3RFD4 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.|||Binds 2 divalent metal cations per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:SLC26A11 ^@ http://purl.uniprot.org/uniprot/G3QEC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/9595:ALDH1B1 ^@ http://purl.uniprot.org/uniprot/G3RUF8 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9595:LOC101134045 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z814|||http://purl.uniprot.org/uniprot/G3SBA1 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/9595:MMP14 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZNE4 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||Cytoplasm|||Melanosome http://togogenome.org/gene/9595:IFI44 ^@ http://purl.uniprot.org/uniprot/G3RCU3 ^@ Similarity ^@ Belongs to the IFI44 family. http://togogenome.org/gene/9595:MYB ^@ http://purl.uniprot.org/uniprot/A0A2I2ZIL5|||http://purl.uniprot.org/uniprot/G3QGB0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SCN5A ^@ http://purl.uniprot.org/uniprot/A0A2I2YCL7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel (TC 1.A.1.10) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.|||Membrane http://togogenome.org/gene/9595:STRADA ^@ http://purl.uniprot.org/uniprot/A0A2I2YMG0|||http://purl.uniprot.org/uniprot/A0A2I2Z7A7|||http://purl.uniprot.org/uniprot/G3QU25 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. http://togogenome.org/gene/9595:MSL3 ^@ http://purl.uniprot.org/uniprot/G3QUN5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:MMACHC ^@ http://purl.uniprot.org/uniprot/G3QRN2 ^@ Similarity ^@ Belongs to the MMACHC family. http://togogenome.org/gene/9595:HTRA3 ^@ http://purl.uniprot.org/uniprot/G3QRI6|||http://purl.uniprot.org/uniprot/G3RXE2 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/9595:TAS2R16 ^@ http://purl.uniprot.org/uniprot/G3R4A4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9595:CHMP2A ^@ http://purl.uniprot.org/uniprot/G3S820 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9595:DYNLRB1 ^@ http://purl.uniprot.org/uniprot/G3SAD4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.|||Belongs to the GAMAD family.|||Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.|||cytoskeleton http://togogenome.org/gene/9595:TMEM39A ^@ http://purl.uniprot.org/uniprot/G3R863 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM39 family.|||Membrane http://togogenome.org/gene/9595:CHST4 ^@ http://purl.uniprot.org/uniprot/G3RIA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/9595:GPR39 ^@ http://purl.uniprot.org/uniprot/G3RFA5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:PFDN4 ^@ http://purl.uniprot.org/uniprot/G3SA67 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/9595:PDE11A ^@ http://purl.uniprot.org/uniprot/G3SKK4 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9595:TBCC ^@ http://purl.uniprot.org/uniprot/G3QSX2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TBCC family.|||Cytoplasm|||Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state. http://togogenome.org/gene/9595:SLITRK3 ^@ http://purl.uniprot.org/uniprot/G3QIK7 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9595:ITGB2 ^@ http://purl.uniprot.org/uniprot/G3REV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane|||Membrane raft http://togogenome.org/gene/9595:B4GAT1 ^@ http://purl.uniprot.org/uniprot/G3R4Q5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 49 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:IARS2 ^@ http://purl.uniprot.org/uniprot/G3QWM6 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9595:PPM1F ^@ http://purl.uniprot.org/uniprot/G3QEE2 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9595:APOLD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YUU2|||http://purl.uniprot.org/uniprot/A0A2I2ZTP6 ^@ Similarity ^@ Belongs to the apolipoprotein L family. http://togogenome.org/gene/9595:ZKSCAN4 ^@ http://purl.uniprot.org/uniprot/G3RTP5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:DEFB121 ^@ http://purl.uniprot.org/uniprot/G3QKC0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9595:LAPTM4A ^@ http://purl.uniprot.org/uniprot/G3S021 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/9595:RARS1 ^@ http://purl.uniprot.org/uniprot/G3R2H6 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9595:PZP ^@ http://purl.uniprot.org/uniprot/G3QT15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.|||Secreted http://togogenome.org/gene/9595:N6AMT1 ^@ http://purl.uniprot.org/uniprot/G3SK75 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal PrmC-related family. http://togogenome.org/gene/9595:FABP9 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZN75 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9595:EHHADH ^@ http://purl.uniprot.org/uniprot/G3QXJ1 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9595:AGK ^@ http://purl.uniprot.org/uniprot/G3RRX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AGK family.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/9595:LOC101131162 ^@ http://purl.uniprot.org/uniprot/G3SKD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:POLR3B ^@ http://purl.uniprot.org/uniprot/A0A2I2Z996 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/9595:GET3 ^@ http://purl.uniprot.org/uniprot/G3QS12 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.|||Belongs to the arsA ATPase family.|||Cytoplasm|||Endoplasmic reticulum|||Homodimer. Component of a transmembrane domain recognition complex (TRC). Interacts with SERP1 and SEC61B. Interacts with WRB.|||nucleolus http://togogenome.org/gene/9595:SLC25A14 ^@ http://purl.uniprot.org/uniprot/A0A2I2YE07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9595:LCE5A ^@ http://purl.uniprot.org/uniprot/G3S955 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9595:EIF5B ^@ http://purl.uniprot.org/uniprot/A0A2I2Z5P7 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. http://togogenome.org/gene/9595:REC8 ^@ http://purl.uniprot.org/uniprot/G3RIZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad21 family.|||Nucleus http://togogenome.org/gene/9595:GUCY2D ^@ http://purl.uniprot.org/uniprot/G3REJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane|||Photoreceptor outer segment membrane http://togogenome.org/gene/9595:GTPBP10 ^@ http://purl.uniprot.org/uniprot/G3SKK6 ^@ Similarity ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. http://togogenome.org/gene/9595:FGF10 ^@ http://purl.uniprot.org/uniprot/G3QPQ1 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9595:SIM1 ^@ http://purl.uniprot.org/uniprot/G3RLN9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:XPOT ^@ http://purl.uniprot.org/uniprot/G3S3K3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus|||tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. http://togogenome.org/gene/9595:RPL34 ^@ http://purl.uniprot.org/uniprot/G3QXE1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/9595:GTPBP8 ^@ http://purl.uniprot.org/uniprot/G3RSD1 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. http://togogenome.org/gene/9595:EDIL3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y2T5|||http://purl.uniprot.org/uniprot/A0A2I2Y8W9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:OGFOD1 ^@ http://purl.uniprot.org/uniprot/G3QIW9 ^@ Similarity ^@ Belongs to the TPA1 family. http://togogenome.org/gene/9595:CLK2 ^@ http://purl.uniprot.org/uniprot/G3R1Y8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:ATP6V1G3 ^@ http://purl.uniprot.org/uniprot/G3QZQ2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9595:LDHAL6B ^@ http://purl.uniprot.org/uniprot/G3S7D5 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/9595:CFAP107 ^@ http://purl.uniprot.org/uniprot/G3RCP7 ^@ Function|||Subcellular Location Annotation ^@ Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.|||cilium axoneme http://togogenome.org/gene/9595:MHC-DMB ^@ http://purl.uniprot.org/uniprot/G3RQJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MHC class I family.|||Endosome membrane|||Lysosome membrane http://togogenome.org/gene/9595:RPS19 ^@ http://purl.uniprot.org/uniprot/G3RGZ2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS19 family. http://togogenome.org/gene/9595:DNASE2 ^@ http://purl.uniprot.org/uniprot/G3QLI8 ^@ Similarity ^@ Belongs to the DNase II family. http://togogenome.org/gene/9595:APOL2 ^@ http://purl.uniprot.org/uniprot/G3S662 ^@ Similarity ^@ Belongs to the apolipoprotein L family. http://togogenome.org/gene/9595:RTN4IP1 ^@ http://purl.uniprot.org/uniprot/G3QYX1 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/9595:THOC6 ^@ http://purl.uniprot.org/uniprot/G3QR25 ^@ Similarity ^@ Belongs to the WD repeat THOC6 family. http://togogenome.org/gene/9595:LHPP ^@ http://purl.uniprot.org/uniprot/A0A2I2YBY1|||http://purl.uniprot.org/uniprot/A0A2I2Z6I8 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/9595:UBLCP1 ^@ http://purl.uniprot.org/uniprot/G3RF15 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:GREM2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZEZ2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9595:LOC101142669 ^@ http://purl.uniprot.org/uniprot/G3S373 ^@ Similarity ^@ Belongs to the Gfa family. http://togogenome.org/gene/9595:SLC39A8 ^@ http://purl.uniprot.org/uniprot/G3QK74 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:PDE6A ^@ http://purl.uniprot.org/uniprot/G3R565 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9595:GLYCTK ^@ http://purl.uniprot.org/uniprot/G3RIE9 ^@ Similarity ^@ Belongs to the glycerate kinase type-2 family. http://togogenome.org/gene/9595:LOC101133451 ^@ http://purl.uniprot.org/uniprot/G3RZU2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme c group covalently per subunit.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9595:RPS7 ^@ http://purl.uniprot.org/uniprot/G3S299 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eS7 family.|||centrosome http://togogenome.org/gene/9595:SUV39H2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZQ90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.|||Nucleus|||centromere http://togogenome.org/gene/9595:RDH10 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y821 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9595:HSPB8 ^@ http://purl.uniprot.org/uniprot/G3RC33 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Cytoplasm|||Displays temperature-dependent chaperone activity.|||Nucleus http://togogenome.org/gene/9595:ALOX5AP ^@ http://purl.uniprot.org/uniprot/G3RDC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:EID2B ^@ http://purl.uniprot.org/uniprot/G3RD06 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:ANK1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YQD4 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/9595:IL1A ^@ http://purl.uniprot.org/uniprot/G3QLV0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-1 family.|||Cytoplasm|||Monomer.|||Nucleus|||Secreted http://togogenome.org/gene/9595:TMEM150A ^@ http://purl.uniprot.org/uniprot/A0A2I2ZPR5|||http://purl.uniprot.org/uniprot/G3QQI7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:AKR1C3 ^@ http://purl.uniprot.org/uniprot/G3QKE2 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9595:PNOC ^@ http://purl.uniprot.org/uniprot/G3RI49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the opioid neuropeptide precursor family.|||Secreted http://togogenome.org/gene/9595:GPC4 ^@ http://purl.uniprot.org/uniprot/G3QDB7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/9595:LOC101141797 ^@ http://purl.uniprot.org/uniprot/G3RAE9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:DPF2 ^@ http://purl.uniprot.org/uniprot/G3S920 ^@ Similarity ^@ Belongs to the requiem/DPF family. http://togogenome.org/gene/9595:PPIE ^@ http://purl.uniprot.org/uniprot/A0A2I2YPM6|||http://purl.uniprot.org/uniprot/A0A2I2ZKE5 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.|||Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. http://togogenome.org/gene/9595:LOXL2 ^@ http://purl.uniprot.org/uniprot/G3RD94 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/9595:DYNC2LI1 ^@ http://purl.uniprot.org/uniprot/G3SFZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light intermediate chain family.|||centrosome|||cilium|||cilium axoneme|||cilium basal body http://togogenome.org/gene/9595:DNMT3B ^@ http://purl.uniprot.org/uniprot/G3R276 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.|||Nucleus http://togogenome.org/gene/9595:THBS1 ^@ http://purl.uniprot.org/uniprot/G3RB36 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:VPS37A ^@ http://purl.uniprot.org/uniprot/G3R7M4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9595:FAM219A ^@ http://purl.uniprot.org/uniprot/A0A2I2YKP2 ^@ Similarity ^@ Belongs to the FAM219 family. http://togogenome.org/gene/9595:SLC25A33 ^@ http://purl.uniprot.org/uniprot/G3S184 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9595:SYNE4 ^@ http://purl.uniprot.org/uniprot/G3QF10 ^@ Similarity ^@ Belongs to the nesprin family. http://togogenome.org/gene/9595:PTPN4 ^@ http://purl.uniprot.org/uniprot/G3QKS3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||May act at junctions between the membrane and the cytoskeleton.|||cytoskeleton http://togogenome.org/gene/9595:PITPNM2 ^@ http://purl.uniprot.org/uniprot/G3QDZ6 ^@ Similarity ^@ Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily. http://togogenome.org/gene/9595:FLOT1 ^@ http://purl.uniprot.org/uniprot/G3QIQ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily.|||Cell membrane|||Endosome|||Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.|||May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.|||Membrane|||Membrane raft|||caveola http://togogenome.org/gene/9595:MTF2 ^@ http://purl.uniprot.org/uniprot/G3QG43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Polycomblike family.|||Nucleus http://togogenome.org/gene/9595:DLX4 ^@ http://purl.uniprot.org/uniprot/G3RG88 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:CDK7 ^@ http://purl.uniprot.org/uniprot/G3RC03 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. http://togogenome.org/gene/9595:PPP3CB ^@ http://purl.uniprot.org/uniprot/A0A2I2Y6B3|||http://purl.uniprot.org/uniprot/G3SGD5 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-2B subfamily. http://togogenome.org/gene/9595:FGF17 ^@ http://purl.uniprot.org/uniprot/G3QVX3 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9595:DRAM1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YWQ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:ST8SIA3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YE49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9595:C17H5orf22 ^@ http://purl.uniprot.org/uniprot/G3R615 ^@ Similarity ^@ Belongs to the UPF0489 family. http://togogenome.org/gene/9595:FH ^@ http://purl.uniprot.org/uniprot/G3R3D3 ^@ Function|||Similarity ^@ Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.|||Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. http://togogenome.org/gene/9595:HMGN5 ^@ http://purl.uniprot.org/uniprot/G3RK21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/9595:PLP1 ^@ http://purl.uniprot.org/uniprot/G3RK50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/9595:MS4A7 ^@ http://purl.uniprot.org/uniprot/G3QH32 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9595:APOA5 ^@ http://purl.uniprot.org/uniprot/G3QEG1 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/9595:SNAP23 ^@ http://purl.uniprot.org/uniprot/G3RIB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP-25 family.|||Cell membrane|||Membrane|||synaptosome http://togogenome.org/gene/9595:PPIL2 ^@ http://purl.uniprot.org/uniprot/G3R2W0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.|||Nucleus http://togogenome.org/gene/9595:EVL ^@ http://purl.uniprot.org/uniprot/A0A2I2ZBT4|||http://purl.uniprot.org/uniprot/G3QSW0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Ena/VASP family.|||Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.|||cytoskeleton http://togogenome.org/gene/9595:LOC101136685 ^@ http://purl.uniprot.org/uniprot/G3RR33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ZNF263 ^@ http://purl.uniprot.org/uniprot/G3R4K3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SNPH ^@ http://purl.uniprot.org/uniprot/G3QLF8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:SNCA ^@ http://purl.uniprot.org/uniprot/P61140 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.|||Belongs to the synuclein family.|||Cytoplasm|||Membrane|||Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (By similarity). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (By similarity). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (By similarity). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (By similarity). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (By similarity). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (By similarity).|||Nucleus|||Phosphorylated, predominantly on serine residues. Phosphorylated on Tyr-125 upon osmotic stress.|||Secreted|||Soluble monomer. Homotetramer. A dynamic intracellular population of tetramers and monomers coexists normally and the tetramer plays an essential role in maintaining homeostasis (By similarity). Interacts with UCHL1 (By similarity). Interacts with phospholipase D and histones. Interacts (via N-terminus) with synphilin-1/SNCAIP; this interaction promotes formation of SNCA inclusions in the cytoplasm. Interacts with CALM1. Interacts with STXBP1; this interaction controls SNCA self-replicating aggregation. Interacts with SNARE components VAMP2 and SNAP25; these interactions allows SNARE complex assembly and integrity (By similarity). Interacts with RPH3A and RAB3A (By similarity). Interacts with SERF1A; this interaction promotes the aggregation of SNCA (By similarity). Interacts with SEPTIN4 (By similarity).|||Synapse|||Ubiquitinated. The predominant conjugate is the diubiquitinated form.|||axon http://togogenome.org/gene/9595:FLNB ^@ http://purl.uniprot.org/uniprot/G3R3J2|||http://purl.uniprot.org/uniprot/G3RYC3 ^@ Similarity ^@ Belongs to the filamin family. http://togogenome.org/gene/9595:RAB4A ^@ http://purl.uniprot.org/uniprot/G3RI48 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. http://togogenome.org/gene/9595:CEP57 ^@ http://purl.uniprot.org/uniprot/A0A2I2YKN5|||http://purl.uniprot.org/uniprot/A0A2I2YYV5|||http://purl.uniprot.org/uniprot/G3RC67 ^@ Similarity ^@ Belongs to the translokin family. http://togogenome.org/gene/9595:MTFMT ^@ http://purl.uniprot.org/uniprot/G3QFN0 ^@ Similarity ^@ Belongs to the Fmt family. http://togogenome.org/gene/9595:KHDC1 ^@ http://purl.uniprot.org/uniprot/G3QVH6 ^@ Similarity ^@ Belongs to the KHDC1 family. http://togogenome.org/gene/9595:HENMT1 ^@ http://purl.uniprot.org/uniprot/G3RVN4 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. HEN1 family. http://togogenome.org/gene/9595:TPD52L3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YIA0 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/9595:DOCK5 ^@ http://purl.uniprot.org/uniprot/G3QP98 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9595:ZDHHC17 ^@ http://purl.uniprot.org/uniprot/G3SEE3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9595:LOC101152908 ^@ http://purl.uniprot.org/uniprot/G3QU60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:TSHB ^@ http://purl.uniprot.org/uniprot/G3R4D3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/9595:SEC11A ^@ http://purl.uniprot.org/uniprot/A0A2I2ZMW9|||http://purl.uniprot.org/uniprot/G3R6A5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Component of the signal peptidase complex.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:SLC30A4 ^@ http://purl.uniprot.org/uniprot/G3RHA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9595:RNF34 ^@ http://purl.uniprot.org/uniprot/G3SFL8 ^@ Subcellular Location Annotation ^@ Cell membrane|||cytosol http://togogenome.org/gene/9595:TMEM205 ^@ http://purl.uniprot.org/uniprot/G3RE74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM205 family.|||Membrane http://togogenome.org/gene/9595:ALDH9A1 ^@ http://purl.uniprot.org/uniprot/G3QF25 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9595:ACSM4 ^@ http://purl.uniprot.org/uniprot/G3QL84 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9595:PCNX3 ^@ http://purl.uniprot.org/uniprot/G3SFE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pecanex family.|||Membrane http://togogenome.org/gene/9595:CLDN2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y2X0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9595:RIBC1 ^@ http://purl.uniprot.org/uniprot/G3RW36 ^@ Similarity ^@ Belongs to the RIB43A family. http://togogenome.org/gene/9595:VGLL1 ^@ http://purl.uniprot.org/uniprot/G3QUK4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs.|||Nucleus http://togogenome.org/gene/9595:ATRNL1 ^@ http://purl.uniprot.org/uniprot/G3SGZ8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:PVALB ^@ http://purl.uniprot.org/uniprot/G3RTP2 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/9595:GHRL ^@ http://purl.uniprot.org/uniprot/A0A2I2ZBQ5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the motilin family.|||Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.|||O-octanoylation is essential for ghrelin activity.|||Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.|||Secreted http://togogenome.org/gene/9595:UBE2T ^@ http://purl.uniprot.org/uniprot/G3QQW9 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9595:TRMT61A ^@ http://purl.uniprot.org/uniprot/G3RSR2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.|||Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.|||Nucleus http://togogenome.org/gene/9595:CCDC90B ^@ http://purl.uniprot.org/uniprot/A0A2I2Y288 ^@ Similarity ^@ Belongs to the CCDC90 family. http://togogenome.org/gene/9595:B4GALNT2 ^@ http://purl.uniprot.org/uniprot/G3RSS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family.|||Membrane http://togogenome.org/gene/9595:LSM2 ^@ http://purl.uniprot.org/uniprot/G3R6X6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||Nucleus http://togogenome.org/gene/9595:SEC61B ^@ http://purl.uniprot.org/uniprot/G3QNK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC61-beta family.|||Endoplasmic reticulum membrane|||Membrane|||Necessary for protein translocation in the endoplasmic reticulum. http://togogenome.org/gene/9595:NUDT2 ^@ http://purl.uniprot.org/uniprot/G3QMT3 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/9595:CCNH ^@ http://purl.uniprot.org/uniprot/A0A2I2ZGP3|||http://purl.uniprot.org/uniprot/G3QR33 ^@ Function|||Similarity|||Subunit ^@ Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.|||Belongs to the cyclin family. Cyclin C subfamily.|||Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. http://togogenome.org/gene/9595:TPRX2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YFL3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SPSB4 ^@ http://purl.uniprot.org/uniprot/G3R7A5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPSB family.|||Cytoplasm http://togogenome.org/gene/9595:SCARA5 ^@ http://purl.uniprot.org/uniprot/G3QHJ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCARA5 family.|||Cell membrane|||Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).|||Homotrimer.|||Membrane http://togogenome.org/gene/9595:GTF2H3 ^@ http://purl.uniprot.org/uniprot/G3R1B1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB4 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.|||Nucleus|||Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7. http://togogenome.org/gene/9595:VOPP1 ^@ http://purl.uniprot.org/uniprot/G3RP07 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VOPP1/ECOP family.|||Cytoplasmic vesicle membrane|||Endosome membrane|||Interacts with WWOX (via WW domain).|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9595:LOC101138012 ^@ http://purl.uniprot.org/uniprot/G3RDN2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:GNAI1 ^@ http://purl.uniprot.org/uniprot/G3QYF3 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9595:IBSP ^@ http://purl.uniprot.org/uniprot/G3QVT7 ^@ Function|||Subcellular Location Annotation ^@ Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.|||Secreted http://togogenome.org/gene/9595:FAM118A ^@ http://purl.uniprot.org/uniprot/G3QH63 ^@ Similarity ^@ Belongs to the FAM118 family. http://togogenome.org/gene/9595:EXOSC7 ^@ http://purl.uniprot.org/uniprot/G3RCD6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:ACSS3 ^@ http://purl.uniprot.org/uniprot/G3R3N2 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9595:LOC101142266 ^@ http://purl.uniprot.org/uniprot/A0A2I2YQV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:CHD3 ^@ http://purl.uniprot.org/uniprot/G3RCF2|||http://purl.uniprot.org/uniprot/G3SAS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/9595:COQ3 ^@ http://purl.uniprot.org/uniprot/G3QUZ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Mitochondrion inner membrane|||O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. http://togogenome.org/gene/9595:KIF13B ^@ http://purl.uniprot.org/uniprot/G3RMN3 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9595:MS4A8 ^@ http://purl.uniprot.org/uniprot/G3QDB4 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9595:PPM1A ^@ http://purl.uniprot.org/uniprot/G3R3K7|||http://purl.uniprot.org/uniprot/G3SHN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PP2C family.|||Membrane|||cytosol http://togogenome.org/gene/9595:HDC ^@ http://purl.uniprot.org/uniprot/A0A2I2YH58|||http://purl.uniprot.org/uniprot/G3S6Z9 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9595:CLDN19 ^@ http://purl.uniprot.org/uniprot/A0A2I2YS39|||http://purl.uniprot.org/uniprot/G3QSH9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9595:NR1H4 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y976|||http://purl.uniprot.org/uniprot/G3QYL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9595:CELSR3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YG79 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor that may have an important role in cell/cell signaling during nervous system formation. http://togogenome.org/gene/9595:NLN ^@ http://purl.uniprot.org/uniprot/A0A2I2ZDD9 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/9595:DDAH2 ^@ http://purl.uniprot.org/uniprot/G3R6S1 ^@ Function|||Similarity ^@ Belongs to the DDAH family.|||Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. http://togogenome.org/gene/9595:ABCD3 ^@ http://purl.uniprot.org/uniprot/G3SJ41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9595:L3HYPDH ^@ http://purl.uniprot.org/uniprot/G3QJ41 ^@ Similarity ^@ Belongs to the proline racemase family. http://togogenome.org/gene/9595:MED15 ^@ http://purl.uniprot.org/uniprot/G3QNJ0|||http://purl.uniprot.org/uniprot/G3S027 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 15 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9595:FZD3 ^@ http://purl.uniprot.org/uniprot/G3RNY6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:HS3ST5 ^@ http://purl.uniprot.org/uniprot/G3QFL4 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9595:TXNL4B ^@ http://purl.uniprot.org/uniprot/A0A2I2Y9F3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/9595:CRHR2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YXL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Membrane http://togogenome.org/gene/9595:FAM32A ^@ http://purl.uniprot.org/uniprot/G3S291 ^@ Similarity ^@ Belongs to the FAM32 family. http://togogenome.org/gene/9595:TOP2A ^@ http://purl.uniprot.org/uniprot/G3S3V9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II topoisomerase family.|||Homodimer.|||Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9595:DEFB119 ^@ http://purl.uniprot.org/uniprot/A4H225|||http://purl.uniprot.org/uniprot/G3QRK3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9595:TNS3 ^@ http://purl.uniprot.org/uniprot/G3QLN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTEN phosphatase protein family.|||focal adhesion http://togogenome.org/gene/9595:LMNB1 ^@ http://purl.uniprot.org/uniprot/G3RWL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intermediate filament family.|||Nucleus lamina http://togogenome.org/gene/9595:ILVBL ^@ http://purl.uniprot.org/uniprot/G3R4U1 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/9595:NSFL1C ^@ http://purl.uniprot.org/uniprot/G3SJI5 ^@ Subcellular Location Annotation|||Subunit ^@ Golgi stack|||Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Binds ubiquitin and mono-ubiquitinated proteins via its N-terminal UBA-like domain when bound to VCP. http://togogenome.org/gene/9595:GAD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZG24 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9595:LOC101133483 ^@ http://purl.uniprot.org/uniprot/G3REG8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9595:CFAP97 ^@ http://purl.uniprot.org/uniprot/G3QX24 ^@ Similarity ^@ Belongs to the CFAP97 family. http://togogenome.org/gene/9595:SIAH2 ^@ http://purl.uniprot.org/uniprot/G3RFD5 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/9595:AKT2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YDQ0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. http://togogenome.org/gene/9595:RHO ^@ http://purl.uniprot.org/uniprot/G3R589 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Contains one covalently linked retinal chromophore.|||Membrane http://togogenome.org/gene/9595:SGK2 ^@ http://purl.uniprot.org/uniprot/G3SEL5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:SLC25A17 ^@ http://purl.uniprot.org/uniprot/G3S3K0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9595:GJA3 ^@ http://purl.uniprot.org/uniprot/G3QHB2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9595:HOATZ ^@ http://purl.uniprot.org/uniprot/G3SE45 ^@ Similarity ^@ Belongs to the HOATZ family. http://togogenome.org/gene/9595:LIMK2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YHM5|||http://purl.uniprot.org/uniprot/A0A2I2ZVF0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. http://togogenome.org/gene/9595:SPCS3 ^@ http://purl.uniprot.org/uniprot/G3RWD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS3 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:LOC101151363 ^@ http://purl.uniprot.org/uniprot/G3RC14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:IL37 ^@ http://purl.uniprot.org/uniprot/A0A2I2YI20|||http://purl.uniprot.org/uniprot/A0A2I2ZTH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9595:FOXR2 ^@ http://purl.uniprot.org/uniprot/G3QYV6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:DGCR6 ^@ http://purl.uniprot.org/uniprot/G3RKM5 ^@ Similarity ^@ Belongs to the gonadal family. http://togogenome.org/gene/9595:PUS1 ^@ http://purl.uniprot.org/uniprot/G3R1B2 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/9595:DSG1 ^@ http://purl.uniprot.org/uniprot/G3QD33 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.|||Membrane|||desmosome http://togogenome.org/gene/9595:CRABP1 ^@ http://purl.uniprot.org/uniprot/G3R4H6 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9595:MSMB ^@ http://purl.uniprot.org/uniprot/G3RFU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-microseminoprotein family.|||Secreted http://togogenome.org/gene/9595:SCD ^@ http://purl.uniprot.org/uniprot/G3QFK6 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Membrane|||The histidine box domains are involved in binding the catalytic metal ions. http://togogenome.org/gene/9595:NDOR1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZSH6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.|||In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||In the N-terminal section; belongs to the flavodoxin family.|||Interacts with CIAPIN1; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.|||NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair.|||perinuclear region http://togogenome.org/gene/9595:TGFB2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZKR7|||http://purl.uniprot.org/uniprot/G3QPK5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.|||extracellular matrix http://togogenome.org/gene/9595:RXFP2 ^@ http://purl.uniprot.org/uniprot/G3QJL3 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:DLG1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y8U0|||http://purl.uniprot.org/uniprot/G3QH48|||http://purl.uniprot.org/uniprot/G3QQG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Membrane http://togogenome.org/gene/9595:LOC129523523 ^@ http://purl.uniprot.org/uniprot/G3QHW8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bZIP family.|||Cytoplasm|||Heterodimer.|||Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.|||Nucleus|||Phosphorylation at serine residues by MAPK14 enhances its transcriptional activation activity while phosphorylation at serine residues by CK2 inhibits its transcriptional activation activity.|||Ubiquitinated, leading to its degradation by the proteasome. http://togogenome.org/gene/9595:SLC17A6 ^@ http://purl.uniprot.org/uniprot/G3RL78 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:CDIPT ^@ http://purl.uniprot.org/uniprot/G3RHV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/9595:CPLX2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y633 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9595:RDH8 ^@ http://purl.uniprot.org/uniprot/G3R961 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Membrane|||Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity. http://togogenome.org/gene/9595:SLC66A1 ^@ http://purl.uniprot.org/uniprot/G3QE42 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:ATP11A ^@ http://purl.uniprot.org/uniprot/A0A2I2YUM4|||http://purl.uniprot.org/uniprot/G3RQB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9595:LOC101126229 ^@ http://purl.uniprot.org/uniprot/G3QPJ0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9595:CLDN3 ^@ http://purl.uniprot.org/uniprot/G3S2W1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the claudin family.|||Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9595:LIX1L ^@ http://purl.uniprot.org/uniprot/G3RMP0 ^@ Similarity ^@ Belongs to the LIX1 family. http://togogenome.org/gene/9595:PRICKLE1 ^@ http://purl.uniprot.org/uniprot/G3S2Z9 ^@ Similarity ^@ Belongs to the prickle / espinas / testin family. http://togogenome.org/gene/9595:TPRKB ^@ http://purl.uniprot.org/uniprot/G3S8Z0 ^@ Similarity ^@ Belongs to the CGI121/TPRKB family. http://togogenome.org/gene/9595:MAGI1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZL88|||http://purl.uniprot.org/uniprot/G3SCC1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:OSBPL1A ^@ http://purl.uniprot.org/uniprot/G3QTD4|||http://purl.uniprot.org/uniprot/G3SJJ5 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9595:GINS2 ^@ http://purl.uniprot.org/uniprot/G3RNK0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS2/PSF2 family.|||Chromosome|||Component of the GINS complex.|||Nucleus http://togogenome.org/gene/9595:ST3GAL6 ^@ http://purl.uniprot.org/uniprot/G3RLE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9595:PWP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZNH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat PWP2 family.|||nucleolus http://togogenome.org/gene/9595:ADCK2 ^@ http://purl.uniprot.org/uniprot/G3R9E7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family. http://togogenome.org/gene/9595:GIPC2 ^@ http://purl.uniprot.org/uniprot/G3QQL5 ^@ Similarity ^@ Belongs to the GIPC family. http://togogenome.org/gene/9595:LOC101136183 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z6M2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:SUSD2 ^@ http://purl.uniprot.org/uniprot/G3QHN9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:C2BH2orf88 ^@ http://purl.uniprot.org/uniprot/G3S0Y2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small membrane AKAP family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:MFSD6L ^@ http://purl.uniprot.org/uniprot/G3QT10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. MFSD6 family.|||Membrane http://togogenome.org/gene/9595:BAX ^@ http://purl.uniprot.org/uniprot/G3RTU9 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9595:AURKC ^@ http://purl.uniprot.org/uniprot/G3QY90 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. http://togogenome.org/gene/9595:ADGRE5 ^@ http://purl.uniprot.org/uniprot/A0A2I2YIG6|||http://purl.uniprot.org/uniprot/A0A2I2YJG6|||http://purl.uniprot.org/uniprot/A0A2I2ZX84 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:SLC19A2 ^@ http://purl.uniprot.org/uniprot/G3SC76 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.|||Cell membrane|||High-affinity transporter for the intake of thiamine. http://togogenome.org/gene/9595:NPPA ^@ http://purl.uniprot.org/uniprot/G3RAZ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the natriuretic peptide family.|||Cell projection|||Homodimer; disulfide-linked antiparallel dimer.|||May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips.|||May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips.|||May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.|||May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips.|||Secreted http://togogenome.org/gene/9595:ANXA1 ^@ http://purl.uniprot.org/uniprot/G3QPT3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Basolateral cell membrane|||Belongs to the annexin family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Early endosome|||Endosome membrane|||Lateral cell membrane|||Membrane|||Nucleus|||The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.|||cilium|||extracellular exosome|||extracellular space|||phagocytic cup|||secretory vesicle lumen http://togogenome.org/gene/9595:TGM1 ^@ http://purl.uniprot.org/uniprot/G3RJ54 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9595:NMS ^@ http://purl.uniprot.org/uniprot/G3RV46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NmU family.|||Secreted http://togogenome.org/gene/9595:CDH9 ^@ http://purl.uniprot.org/uniprot/G3R9J0 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ERC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y258|||http://purl.uniprot.org/uniprot/A0A2I2Y2U7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:NAGA ^@ http://purl.uniprot.org/uniprot/G3QXZ9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 27 family.|||Homodimer.|||Lysosome http://togogenome.org/gene/9595:MRPL16 ^@ http://purl.uniprot.org/uniprot/G3S6I0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/9595:FABP1 ^@ http://purl.uniprot.org/uniprot/G3R258 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.|||Cytoplasm|||Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. http://togogenome.org/gene/9595:SPARCL1 ^@ http://purl.uniprot.org/uniprot/G3RHD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPARC family.|||extracellular matrix http://togogenome.org/gene/9595:ZNF768 ^@ http://purl.uniprot.org/uniprot/G3SGB9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:ADAM15 ^@ http://purl.uniprot.org/uniprot/A0A2I2YJI0|||http://purl.uniprot.org/uniprot/A0A2I2YLZ1|||http://purl.uniprot.org/uniprot/A0A2I2ZX51|||http://purl.uniprot.org/uniprot/G3RDF4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:TRIM5 ^@ http://purl.uniprot.org/uniprot/Q5C8T6 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Autoubiquitinated in a RING finger- and UBE2D2-dependent manner. Monoubiquitinated by TRIM21. Deubiquitinated by Yersinia YopJ. Ubiquitination may not lead to proteasomal degradation (By similarity).|||Belongs to the TRIM/RBCC family.|||Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.|||Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2.|||Cytoplasm|||Degraded in a proteasome-independent fashion in the absence of viral infection but in a proteasome-dependent fashion following exposure to restriction sensitive virus.|||Nucleus|||The B box-type zinc finger domain and the coiled-coil domain contribute to the higher and low order multimerization respectively which is essential for restriction activity. The coiled coil domain is important for higher order multimerization by promoting the initial dimerization.|||The B30.2/SPRY domain acts as a capsid recognition domain. Polymorphisms in this domain explain the observed species-specific differences among orthologs (By similarity).|||The RING-type zinc finger domain confers E3 ubiquitin ligase activity and is essential for retrovirus restriction activity, autoubiquitination and higher-order multimerization. http://togogenome.org/gene/9595:LOC101150369 ^@ http://purl.uniprot.org/uniprot/G3SKC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/9595:GSDMB ^@ http://purl.uniprot.org/uniprot/A0A2I2YG62|||http://purl.uniprot.org/uniprot/G3QZ02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gasdermin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:CLDN24 ^@ http://purl.uniprot.org/uniprot/G3RZ65 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9595:UNC45A ^@ http://purl.uniprot.org/uniprot/G3QYT2 ^@ Subcellular Location Annotation ^@ perinuclear region http://togogenome.org/gene/9595:RNF121 ^@ http://purl.uniprot.org/uniprot/G3SB30 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:FXN ^@ http://purl.uniprot.org/uniprot/A0A2I2ZHU2 ^@ Similarity ^@ Belongs to the frataxin family. http://togogenome.org/gene/9595:TPM4 ^@ http://purl.uniprot.org/uniprot/A0A2I2YC45|||http://purl.uniprot.org/uniprot/A0A2I2Z1M4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9595:EZH2 ^@ http://purl.uniprot.org/uniprot/G3S979 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:MORF4L1 ^@ http://purl.uniprot.org/uniprot/G3RM80|||http://purl.uniprot.org/uniprot/G3RY52 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:RAD54L2 ^@ http://purl.uniprot.org/uniprot/G3R3H8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/9595:NDUFA7 ^@ http://purl.uniprot.org/uniprot/G3QF48 ^@ Function|||Similarity|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA7 subunit family.|||Complex I is composed of 45 different subunits. http://togogenome.org/gene/9595:TRAK1 ^@ http://purl.uniprot.org/uniprot/G3QHQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the milton family.|||Early endosome|||Mitochondrion http://togogenome.org/gene/9595:CHL1 ^@ http://purl.uniprot.org/uniprot/G3R020 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. http://togogenome.org/gene/9595:OXCT1 ^@ http://purl.uniprot.org/uniprot/G3S0S5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 3-oxoacid CoA-transferase family.|||Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.|||Mitochondrion http://togogenome.org/gene/9595:SLC4A9 ^@ http://purl.uniprot.org/uniprot/G3QDG4 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9595:TRIAP1 ^@ http://purl.uniprot.org/uniprot/G3RR18 ^@ Similarity ^@ Belongs to the TRIAP1/MDM35 family. http://togogenome.org/gene/9595:SERPINA6 ^@ http://purl.uniprot.org/uniprot/G3QXY9 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9595:ICAM4 ^@ http://purl.uniprot.org/uniprot/G3QT47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. ICAM family.|||Membrane http://togogenome.org/gene/9595:LLPH ^@ http://purl.uniprot.org/uniprot/G3SJL3 ^@ Similarity ^@ Belongs to the learning-associated protein family. http://togogenome.org/gene/9595:CDC14B ^@ http://purl.uniprot.org/uniprot/G3R0U4 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily. http://togogenome.org/gene/9595:ANAPC5 ^@ http://purl.uniprot.org/uniprot/G3QZZ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APC5 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|||spindle http://togogenome.org/gene/9595:BPIFB2 ^@ http://purl.uniprot.org/uniprot/G3R502 ^@ Similarity ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. http://togogenome.org/gene/9595:TRIQK ^@ http://purl.uniprot.org/uniprot/A0A2I2Y3I2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIQK family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:GABRB2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YKJ9|||http://purl.uniprot.org/uniprot/G3RF14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9595:BLVRA ^@ http://purl.uniprot.org/uniprot/A0A2I2Z6L1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily.|||Monomer.|||Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.|||cytosol http://togogenome.org/gene/9595:LOC101145725 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZKL9 ^@ Similarity ^@ Belongs to the PRAME family. http://togogenome.org/gene/9595:PPRC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YUV5|||http://purl.uniprot.org/uniprot/A0A2I2ZSY4|||http://purl.uniprot.org/uniprot/G3QIB7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SERPINE1 ^@ http://purl.uniprot.org/uniprot/G3QW76 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9595:C8A ^@ http://purl.uniprot.org/uniprot/G3RDM3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Secreted http://togogenome.org/gene/9595:CHAC1 ^@ http://purl.uniprot.org/uniprot/G3SI09 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.|||Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. http://togogenome.org/gene/9595:FLI1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZEQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9595:PEX2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z8W1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pex2/pex10/pex12 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9595:SLC25A18 ^@ http://purl.uniprot.org/uniprot/G3RGB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9595:SUB1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YAN8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transcriptional coactivator PC4 family.|||General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).|||Homodimer. Interacts with CSTF2.|||Nucleus http://togogenome.org/gene/9595:GJB5 ^@ http://purl.uniprot.org/uniprot/G3R0Q7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9595:DAG1 ^@ http://purl.uniprot.org/uniprot/G3R897 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.|||Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.|||cytoskeleton|||extracellular space|||nucleoplasm|||sarcolemma http://togogenome.org/gene/9595:IL7 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y631|||http://purl.uniprot.org/uniprot/A0A2I2YQZ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-7/IL-9 family.|||Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis.|||Interacts with IL7R and CSF2RG.|||Secreted http://togogenome.org/gene/9595:NAALADL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YMK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:CCNE2 ^@ http://purl.uniprot.org/uniprot/G3RG37 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9595:COQ5 ^@ http://purl.uniprot.org/uniprot/G3R0B6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).|||Mitochondrion inner membrane http://togogenome.org/gene/9595:SLC2A9 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZP61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Cell membrane http://togogenome.org/gene/9595:SLC17A7 ^@ http://purl.uniprot.org/uniprot/G3RKG3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:CCL21 ^@ http://purl.uniprot.org/uniprot/G3S8M0 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9595:RPL15 ^@ http://purl.uniprot.org/uniprot/G3SD81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL15 family.|||Cytoplasm http://togogenome.org/gene/9595:VAPB ^@ http://purl.uniprot.org/uniprot/A0A2I2YJ68|||http://purl.uniprot.org/uniprot/G3QXS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:BTAF1 ^@ http://purl.uniprot.org/uniprot/G3S6X7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:TMPRSS4 ^@ http://purl.uniprot.org/uniprot/G3SF67 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:LOC109028241 ^@ http://purl.uniprot.org/uniprot/G3RM01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:TLR7 ^@ http://purl.uniprot.org/uniprot/G3RXT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9595:LVRN ^@ http://purl.uniprot.org/uniprot/G3QWK5 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9595:CDH19 ^@ http://purl.uniprot.org/uniprot/G3S948 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:EMP3 ^@ http://purl.uniprot.org/uniprot/G3RGJ1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Probably involved in cell proliferation and cell-cell interactions. http://togogenome.org/gene/9595:FTSJ1 ^@ http://purl.uniprot.org/uniprot/G3SK06 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.|||Cytoplasm|||Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. http://togogenome.org/gene/9595:TMEM30A ^@ http://purl.uniprot.org/uniprot/G3QLR5 ^@ Similarity ^@ Belongs to the CDC50/LEM3 family. http://togogenome.org/gene/9595:IWS1 ^@ http://purl.uniprot.org/uniprot/G3R4F3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:CEP43 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZG60|||http://purl.uniprot.org/uniprot/A0A2I2ZH15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP43 family.|||centriole|||cilium basal body http://togogenome.org/gene/9595:G0S2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z078 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Directly interacts with BCL2; this interaction prevents the formation of the anti-apoptotic BAX-BCL2 complex.|||Mitochondrion|||Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers. http://togogenome.org/gene/9595:EMP1 ^@ http://purl.uniprot.org/uniprot/G3SHA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/9595:ARHGEF2 ^@ http://purl.uniprot.org/uniprot/G3SHS4 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Golgi apparatus|||Vesicle|||spindle|||tight junction http://togogenome.org/gene/9595:LOC101146459 ^@ http://purl.uniprot.org/uniprot/G3S9G4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ACTBL2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZEN8 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9595:PHACTR2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z3J2|||http://purl.uniprot.org/uniprot/A0A2I2ZNH1|||http://purl.uniprot.org/uniprot/G3RSU5 ^@ Similarity|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin. http://togogenome.org/gene/9595:HTR2A ^@ http://purl.uniprot.org/uniprot/A0A2I2YKA3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasmic vesicle|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin).|||Membrane|||Presynapse|||Synapse|||Vesicle|||axon|||caveola|||dendrite http://togogenome.org/gene/9595:B3GALT2 ^@ http://purl.uniprot.org/uniprot/G3S7A4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:ASIP ^@ http://purl.uniprot.org/uniprot/G3SDS8 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9595:PEX3 ^@ http://purl.uniprot.org/uniprot/G3RJA6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with PEX19.|||Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.|||Peroxisome membrane http://togogenome.org/gene/9595:NOSIP ^@ http://purl.uniprot.org/uniprot/G3QVS3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOSIP family.|||Cytoplasm|||Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.|||Nucleus http://togogenome.org/gene/9595:LOC101137790 ^@ http://purl.uniprot.org/uniprot/G3R8R1 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9595:GNAZ ^@ http://purl.uniprot.org/uniprot/G3RJV2 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9595:VEZT ^@ http://purl.uniprot.org/uniprot/G3S6Z0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vezatin family.|||Cell membrane|||Membrane|||Nucleus|||adherens junction http://togogenome.org/gene/9595:TMEM170A ^@ http://purl.uniprot.org/uniprot/A0A2I2YFG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM170 family.|||Membrane http://togogenome.org/gene/9595:ZPBP ^@ http://purl.uniprot.org/uniprot/G3RKU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the zona pellucida-binding protein Sp38 family.|||Secreted|||acrosome http://togogenome.org/gene/9595:CCDC85A ^@ http://purl.uniprot.org/uniprot/G3R6Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC85 family.|||adherens junction http://togogenome.org/gene/9595:KCNJ3 ^@ http://purl.uniprot.org/uniprot/G3SFZ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.|||Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.|||Membrane|||This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat. http://togogenome.org/gene/9595:AP3M1 ^@ http://purl.uniprot.org/uniprot/G3R698 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. http://togogenome.org/gene/9595:APOC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YNH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the apolipoprotein C1 family.|||Secreted http://togogenome.org/gene/9595:MCM7 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y544|||http://purl.uniprot.org/uniprot/G3QJU2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Nucleus http://togogenome.org/gene/9595:COQ10B ^@ http://purl.uniprot.org/uniprot/A0A2I2ZRA8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the COQ10 family.|||Interacts with coenzyme Q.|||Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. http://togogenome.org/gene/9595:LHFPL5 ^@ http://purl.uniprot.org/uniprot/G3SGN3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:CLRN2 ^@ http://purl.uniprot.org/uniprot/G3SA32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/9595:NR1D2 ^@ http://purl.uniprot.org/uniprot/G3QL26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9595:ANAPC13 ^@ http://purl.uniprot.org/uniprot/G3R8C4 ^@ Function|||Similarity ^@ Belongs to the APC13 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. http://togogenome.org/gene/9595:TAPT1 ^@ http://purl.uniprot.org/uniprot/G3R827 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAPT1 family.|||Membrane http://togogenome.org/gene/9595:PRKD2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZRU3 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by DAG and phorbol esters.|||Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/9595:DERL2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YCV5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:MAOA ^@ http://purl.uniprot.org/uniprot/G3R0P3 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/9595:TP63 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z434|||http://purl.uniprot.org/uniprot/A0A2I2ZLA8|||http://purl.uniprot.org/uniprot/G3QQY2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.|||Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.|||Belongs to the p53 family.|||Binds 1 zinc ion per subunit.|||Binds DNA as a homotetramer.|||Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:SLC5A9 ^@ http://purl.uniprot.org/uniprot/G3R8X7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:WNT2B ^@ http://purl.uniprot.org/uniprot/G3QM25 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9595:NPAS1 ^@ http://purl.uniprot.org/uniprot/G3RC50 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:ZNF197 ^@ http://purl.uniprot.org/uniprot/A0A2I2YVE2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:C9 ^@ http://purl.uniprot.org/uniprot/G3RIM1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Secreted http://togogenome.org/gene/9595:AMZ1 ^@ http://purl.uniprot.org/uniprot/G3QK80 ^@ Function|||Similarity ^@ Belongs to the peptidase M54 family.|||Probable zinc metalloprotease. http://togogenome.org/gene/9595:KHDC3L ^@ http://purl.uniprot.org/uniprot/G3QXQ1 ^@ Similarity ^@ Belongs to the KHDC1 family. http://togogenome.org/gene/9595:NFIL3 ^@ http://purl.uniprot.org/uniprot/G3QG48 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. Protects pro-B cells from programmed cell death.|||Belongs to the bZIP family. NFIL3 subfamily.|||Homodimer. Binds DNA as a dimer.|||Nucleus http://togogenome.org/gene/9595:EIF2B5 ^@ http://purl.uniprot.org/uniprot/G3QWV1 ^@ Similarity ^@ Belongs to the eIF-2B gamma/epsilon subunits family. http://togogenome.org/gene/9595:NRXN1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y2M8|||http://purl.uniprot.org/uniprot/A0A2I2ZUG4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Presynaptic cell membrane http://togogenome.org/gene/9595:IQCD ^@ http://purl.uniprot.org/uniprot/G3RNN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC10 family.|||Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.|||flagellum axoneme http://togogenome.org/gene/9595:CD5 ^@ http://purl.uniprot.org/uniprot/G3QUT8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:MMS19 ^@ http://purl.uniprot.org/uniprot/G3QKT3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MET18/MMS19 family.|||Component of the CIA complex.|||Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.|||Nucleus|||spindle http://togogenome.org/gene/9595:BABAM2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YFB1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BABAM2 family.|||Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.|||Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.|||Cytoplasm|||May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.|||Nucleus http://togogenome.org/gene/9595:ST3GAL5 ^@ http://purl.uniprot.org/uniprot/G3S1R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9595:PHKA1 ^@ http://purl.uniprot.org/uniprot/G3QV86 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.|||Belongs to the phosphorylase b kinase regulatory chain family.|||Cell membrane|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.|||Membrane|||Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. http://togogenome.org/gene/9595:SERPINA12 ^@ http://purl.uniprot.org/uniprot/G3QU16 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9595:GPR17 ^@ http://purl.uniprot.org/uniprot/G3QPZ8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:GHR ^@ http://purl.uniprot.org/uniprot/A0A2I2Y9H0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||Cell membrane|||The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. http://togogenome.org/gene/9595:ABCG5 ^@ http://purl.uniprot.org/uniprot/G3QEB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/9595:LOC101150488 ^@ http://purl.uniprot.org/uniprot/G3QHY0 ^@ Similarity ^@ Belongs to the PRAME family. http://togogenome.org/gene/9595:CHM ^@ http://purl.uniprot.org/uniprot/G3RQ74 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. http://togogenome.org/gene/9595:PLA2G2E ^@ http://purl.uniprot.org/uniprot/G3RCC5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9595:CDCA5 ^@ http://purl.uniprot.org/uniprot/A0A2I2YL62 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus http://togogenome.org/gene/9595:MRPL34 ^@ http://purl.uniprot.org/uniprot/G3QSN3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/9595:HADH ^@ http://purl.uniprot.org/uniprot/G3QP50 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/9595:SMIM22 ^@ http://purl.uniprot.org/uniprot/A0A2I2YEH1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:PAPSS1 ^@ http://purl.uniprot.org/uniprot/G3RFL2 ^@ Similarity ^@ In the C-terminal section; belongs to the sulfate adenylyltransferase family.|||In the N-terminal section; belongs to the APS kinase family. http://togogenome.org/gene/9595:MOB1A ^@ http://purl.uniprot.org/uniprot/G3S3V8 ^@ Similarity ^@ Belongs to the MOB1/phocein family. http://togogenome.org/gene/9595:UTP15 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZXL7 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9595:ACY3 ^@ http://purl.uniprot.org/uniprot/G3R8H3 ^@ Cofactor|||Similarity ^@ Belongs to the AspA/AstE family. Aspartoacylase subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9595:PPFIA1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YW20|||http://purl.uniprot.org/uniprot/A0A2I2ZKM7|||http://purl.uniprot.org/uniprot/G3RBT5 ^@ Similarity ^@ Belongs to the liprin family. Liprin-alpha subfamily. http://togogenome.org/gene/9595:LOC101137471 ^@ http://purl.uniprot.org/uniprot/G3S0Z6 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9595:LOC101136413 ^@ http://purl.uniprot.org/uniprot/G3RLF1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:SOD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z7B3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Cu-Zn superoxide dismutase family.|||Binds 1 copper ion per subunit.|||Binds 1 zinc ion per subunit.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/9595:BMPR1B ^@ http://purl.uniprot.org/uniprot/G3R8S9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9595:MMP9 ^@ http://purl.uniprot.org/uniprot/G3RCL1 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||extracellular matrix http://togogenome.org/gene/9595:C18H18orf21 ^@ http://purl.uniprot.org/uniprot/A0A2I2YMY3 ^@ Similarity ^@ Belongs to the UPF0711 family. http://togogenome.org/gene/9595:MIPEP ^@ http://purl.uniprot.org/uniprot/G3R1X7 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/9595:PELO ^@ http://purl.uniprot.org/uniprot/G3RA63 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, pelo recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel.|||Cytoplasm http://togogenome.org/gene/9595:LCAT ^@ http://purl.uniprot.org/uniprot/G3QQL2 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9595:TMEM150B ^@ http://purl.uniprot.org/uniprot/G3QDZ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:RRS1 ^@ http://purl.uniprot.org/uniprot/G3RU40 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRS1 family.|||Involved in ribosomal large subunit assembly.|||Nucleus http://togogenome.org/gene/9595:LIN28A ^@ http://purl.uniprot.org/uniprot/A0A2I2ZBW7 ^@ Similarity ^@ Belongs to the lin-28 family. http://togogenome.org/gene/9595:CMTR1 ^@ http://purl.uniprot.org/uniprot/G3QSA2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with POLR2A (via C-terminus).|||Nucleus|||S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).|||S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. http://togogenome.org/gene/9595:ASB13 ^@ http://purl.uniprot.org/uniprot/G3QDY4 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9595:RAB14 ^@ http://purl.uniprot.org/uniprot/G3S102 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Recycling endosome|||phagosome|||trans-Golgi network membrane http://togogenome.org/gene/9595:RPP30 ^@ http://purl.uniprot.org/uniprot/G3RXX6 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal RNase P protein component 3 family. http://togogenome.org/gene/9595:CMKLR1 ^@ http://purl.uniprot.org/uniprot/G3R3P8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:SLC25A38 ^@ http://purl.uniprot.org/uniprot/G3RCH1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.|||Membrane|||Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.|||Mitochondrion inner membrane|||Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis. http://togogenome.org/gene/9595:EIF4E2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z113|||http://purl.uniprot.org/uniprot/A0A2I2ZEB1|||http://purl.uniprot.org/uniprot/A0A2I2ZKU3 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/9595:LOC101150976 ^@ http://purl.uniprot.org/uniprot/G3R6Z1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9595:PEX5L ^@ http://purl.uniprot.org/uniprot/A0A2I2YCR6|||http://purl.uniprot.org/uniprot/A0A2I2YTV2|||http://purl.uniprot.org/uniprot/A0A2I2ZH83|||http://purl.uniprot.org/uniprot/A0A2I2ZU12|||http://purl.uniprot.org/uniprot/G3QKH7 ^@ Similarity ^@ Belongs to the peroxisomal targeting signal receptor family. http://togogenome.org/gene/9595:TSPAN4 ^@ http://purl.uniprot.org/uniprot/G3R5H7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9595:PHTF2 ^@ http://purl.uniprot.org/uniprot/G3S236 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:IDH2 ^@ http://purl.uniprot.org/uniprot/G3QQB8 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Homodimer. http://togogenome.org/gene/9595:LOC101141137 ^@ http://purl.uniprot.org/uniprot/G3QV65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ATP5PO ^@ http://purl.uniprot.org/uniprot/G3RA47 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase delta chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:SDHAF1 ^@ http://purl.uniprot.org/uniprot/G3R6P0 ^@ Similarity ^@ Belongs to the complex I LYR family. SDHAF1 subfamily. http://togogenome.org/gene/9595:FAM76B ^@ http://purl.uniprot.org/uniprot/G3RC57 ^@ Similarity ^@ Belongs to the FAM76 family. http://togogenome.org/gene/9595:DTNB ^@ http://purl.uniprot.org/uniprot/A0A2I2ZG45|||http://purl.uniprot.org/uniprot/A0A2I2ZKZ6|||http://purl.uniprot.org/uniprot/G3QXH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dystrophin family. Dystrobrevin subfamily.|||Cytoplasm http://togogenome.org/gene/9595:CLTCL1 ^@ http://purl.uniprot.org/uniprot/G3S0H9|||http://purl.uniprot.org/uniprot/G3S7V0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin heavy chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||Membrane|||coated pit http://togogenome.org/gene/9595:ACO1 ^@ http://purl.uniprot.org/uniprot/G3RJN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Cytoplasm http://togogenome.org/gene/9595:RGMB ^@ http://purl.uniprot.org/uniprot/G3SBT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the repulsive guidance molecule (RGM) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:NDUFAF1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZYF3|||http://purl.uniprot.org/uniprot/Q0MQ83 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.|||Belongs to the CIA30 family.|||Mitochondrion|||Mitochondrion matrix|||Part of the mitochondrial complex I assembly/MCIA complex that comprises at least the core subunits TMEM126B, NDUFAF1, ECSIT and ACAD9 and complement subunits such as COA1 and TMEM186. Interacts with ECSIT. Interacts with ACAD9. At early stages of complex I assembly, it is found in intermediate subcomplexes that contain different subunits including NDUFB6, NDUFA6, NDUFA9, NDUFS3, NDUFS7, ND1, ND2 and ND3. Interacts with TMEM70 and TMEM242 (By similarity). http://togogenome.org/gene/9595:RGR ^@ http://purl.uniprot.org/uniprot/A0A2I2Z6P6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:TPST2 ^@ http://purl.uniprot.org/uniprot/G3QQN6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein sulfotransferase family.|||Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.|||Golgi apparatus membrane http://togogenome.org/gene/9595:SLA2 ^@ http://purl.uniprot.org/uniprot/G3RAU1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:TMPRSS15 ^@ http://purl.uniprot.org/uniprot/G3QEB0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DMBT1 family.|||Belongs to the peptidase S1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases. http://togogenome.org/gene/9595:SYP ^@ http://purl.uniprot.org/uniprot/G3QG14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/9595:DGAT1 ^@ http://purl.uniprot.org/uniprot/G3RU45 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Homodimer or homotetramer; both forms have similar enzymatic activities.|||Membrane http://togogenome.org/gene/9595:LOC101143900 ^@ http://purl.uniprot.org/uniprot/G3QS82 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9595:NFX1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZQ24|||http://purl.uniprot.org/uniprot/G3QV50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NFX1 family.|||Nucleus http://togogenome.org/gene/9595:LOC101126456 ^@ http://purl.uniprot.org/uniprot/G3RHD9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9595:MAP7D3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YJK5 ^@ Similarity ^@ Belongs to the MAP7 family. http://togogenome.org/gene/9595:ADAMTS16 ^@ http://purl.uniprot.org/uniprot/G3RFX7 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9595:ACAD9 ^@ http://purl.uniprot.org/uniprot/G3R2D4 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9595:MAP7 ^@ http://purl.uniprot.org/uniprot/A0A2I2YR22|||http://purl.uniprot.org/uniprot/A0A2I2Z0C0 ^@ Similarity ^@ Belongs to the MAP7 family. http://togogenome.org/gene/9595:DNAJC22 ^@ http://purl.uniprot.org/uniprot/G3SJ05 ^@ Function|||Subcellular Location Annotation ^@ May function as a co-chaperone.|||Membrane http://togogenome.org/gene/9595:CEBPE ^@ http://purl.uniprot.org/uniprot/G3QWU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. C/EBP subfamily.|||Nucleus http://togogenome.org/gene/9595:CTNNAL1 ^@ http://purl.uniprot.org/uniprot/G3QNN9 ^@ Similarity ^@ Belongs to the vinculin/alpha-catenin family. http://togogenome.org/gene/9595:NFIB ^@ http://purl.uniprot.org/uniprot/A0A2I2ZKD3|||http://purl.uniprot.org/uniprot/G3S9D9|||http://purl.uniprot.org/uniprot/G3SIQ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTF/NF-I family.|||Binds DNA as a homodimer.|||Nucleus|||Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. http://togogenome.org/gene/9595:NDUFC2 ^@ http://purl.uniprot.org/uniprot/Q0MQF8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis but required for the complex assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFC2 subunit family.|||Complex I is composed of 45 different subunits. Interacts with TMEM242 (By similarity).|||Mitochondrion inner membrane http://togogenome.org/gene/9595:QTRT2 ^@ http://purl.uniprot.org/uniprot/G3S8V7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.|||Mitochondrion outer membrane|||Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). http://togogenome.org/gene/9595:ARID5B ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1S3|||http://purl.uniprot.org/uniprot/G3QND9 ^@ Similarity ^@ Belongs to the ARID5B family. http://togogenome.org/gene/9595:RPS11 ^@ http://purl.uniprot.org/uniprot/G3QKB6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/9595:LOC101135314 ^@ http://purl.uniprot.org/uniprot/G3SA70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:SLC16A1 ^@ http://purl.uniprot.org/uniprot/G3RHM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/9595:LOC101139165 ^@ http://purl.uniprot.org/uniprot/G3RGI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane http://togogenome.org/gene/9595:ARL1 ^@ http://purl.uniprot.org/uniprot/G3R5E4 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9595:TRMT13 ^@ http://purl.uniprot.org/uniprot/G3QS72 ^@ Function|||Similarity ^@ Belongs to the methyltransferase TRM13 family.|||tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His). http://togogenome.org/gene/9595:CD164 ^@ http://purl.uniprot.org/uniprot/G3QLH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD164 family.|||Membrane http://togogenome.org/gene/9595:CHMP7 ^@ http://purl.uniprot.org/uniprot/G3QJA9 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9595:ZEB2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z563|||http://purl.uniprot.org/uniprot/A0A2I2ZGH3 ^@ Similarity ^@ Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family. http://togogenome.org/gene/9595:GGT6 ^@ http://purl.uniprot.org/uniprot/A0A2I2YKH0|||http://purl.uniprot.org/uniprot/G3QU68 ^@ Similarity ^@ Belongs to the gamma-glutamyltransferase family. http://togogenome.org/gene/9595:NOX3 ^@ http://purl.uniprot.org/uniprot/G3RI51 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:KRT38 ^@ http://purl.uniprot.org/uniprot/G3SI50 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:GABRA3 ^@ http://purl.uniprot.org/uniprot/G3SKG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9595:SLC39A7 ^@ http://purl.uniprot.org/uniprot/G3R2Y9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:FAM234A ^@ http://purl.uniprot.org/uniprot/G3RC02 ^@ Similarity ^@ Belongs to the FAM234 family. http://togogenome.org/gene/9595:TJAP1 ^@ http://purl.uniprot.org/uniprot/G3RGQ9|||http://purl.uniprot.org/uniprot/G3RYF0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:SLC4A1 ^@ http://purl.uniprot.org/uniprot/G3RRW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:LOC101154093 ^@ http://purl.uniprot.org/uniprot/G3RH36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lambda interferon family.|||Secreted http://togogenome.org/gene/9595:FOLR2 ^@ http://purl.uniprot.org/uniprot/G3R6P4 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/9595:ZNF622 ^@ http://purl.uniprot.org/uniprot/G3RSF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the REI1 family.|||Cytoplasm http://togogenome.org/gene/9595:PTP4A3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YS06 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9595:RPL41 ^@ http://purl.uniprot.org/uniprot/A0A2I2YS91 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL41 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/9595:H1-1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YJH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9595:NEU2 ^@ http://purl.uniprot.org/uniprot/G3QRW5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/9595:KCNH1 ^@ http://purl.uniprot.org/uniprot/G3SKG7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:S100A2 ^@ http://purl.uniprot.org/uniprot/G3RYQ2 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9595:SUPT20H ^@ http://purl.uniprot.org/uniprot/A0A2I2Y7K6|||http://purl.uniprot.org/uniprot/G3R8D6|||http://purl.uniprot.org/uniprot/G3SJR6 ^@ Similarity ^@ Belongs to the SPT20 family. http://togogenome.org/gene/9595:BAP1 ^@ http://purl.uniprot.org/uniprot/G3RIK2 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/9595:FAM47B ^@ http://purl.uniprot.org/uniprot/G3QGX4 ^@ Similarity ^@ Belongs to the FAM47 family. http://togogenome.org/gene/9595:KRT222 ^@ http://purl.uniprot.org/uniprot/G3RCY3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:FAM133A ^@ http://purl.uniprot.org/uniprot/A0A2I2YMD1 ^@ Similarity ^@ Belongs to the FAM133 family. http://togogenome.org/gene/9595:ST14 ^@ http://purl.uniprot.org/uniprot/G3S550 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S1 family.|||Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.|||Interacts with CDCP1. May interact with TMEFF1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:DHCR7 ^@ http://purl.uniprot.org/uniprot/G3QUK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Membrane http://togogenome.org/gene/9595:PROM2 ^@ http://purl.uniprot.org/uniprot/G3QUE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prominin family.|||Membrane|||microvillus membrane http://togogenome.org/gene/9595:GAPDH ^@ http://purl.uniprot.org/uniprot/G3R288 ^@ Similarity|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/9595:ILF3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YPJ5|||http://purl.uniprot.org/uniprot/G3QNF4 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9595:PDRG1 ^@ http://purl.uniprot.org/uniprot/G3S683 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.|||Cytoplasm|||May play a role in chaperone-mediated protein folding. http://togogenome.org/gene/9595:CPNE6 ^@ http://purl.uniprot.org/uniprot/A0A2I2YT19 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9595:RNF8 ^@ http://purl.uniprot.org/uniprot/G3RG85 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ According to a well-established model, RNF8 initiate H2A 'Lys-63'-linked ubiquitination leading to recruitment of RNF168 to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.|||Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger.|||Belongs to the CHFR family.|||Belongs to the RNF8 family.|||Cytoplasm|||E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains. Promotes non-homologous end joining (NHEJ) by promoting the 'Lys-48'-linked ubiquitination and degradation the of KU80/XRCC5. Following DNA damage, mediates the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF168, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Following DNA damage, mediates the ubiquitination and degradation of POLD4/p12, a subunit of DNA polymerase delta. In the absence of POLD4, DNA polymerase delta complex exhibits higher proofreading activity. In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation. Involved in the activation of ATM by promoting histone H2B ubiquitination, which indirectly triggers histone H4 'Lys-16' acetylation (H4K16ac), establishing a chromatin environment that promotes efficient activation of ATM kinase. Required in the testis, where it plays a role in the replacement of histones during spermatogenesis. At uncapped telomeres, promotes the joining of deprotected chromosome ends by inducing H2A ubiquitination and TP53BP1 recruitment, suggesting that it may enhance cancer development by aggravating telomere-induced genome instability in case of telomeric crisis. Promotes the assembly of RAD51 at DNA DSBs in the absence of BRCA1 and TP53BP1 Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. May be required for proper exit from mitosis after spindle checkpoint activation and may regulate cytokinesis. May play a role in the regulation of RXRA-mediated transcriptional activity. Not involved in RXRA ubiquitination by UBE2E2.|||Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N. Interacts with RXRA. Interacts (via FHA domain) with phosphorylated HERC2 (via C-terminus). Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm.|||Midbody|||Nucleus|||The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and phosphorylated HERC2.|||telomere http://togogenome.org/gene/9595:PI4K2A ^@ http://purl.uniprot.org/uniprot/G3RGW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.|||Membrane http://togogenome.org/gene/9595:ALKBH8 ^@ http://purl.uniprot.org/uniprot/G3RHK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alkB family.|||Cytoplasm http://togogenome.org/gene/9595:ERLIN2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YUD9|||http://purl.uniprot.org/uniprot/G3RAR7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the band 7/mec-2 family.|||Endoplasmic reticulum membrane|||Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.|||Membrane http://togogenome.org/gene/9595:ARL14 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZPU2 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9595:POLR2D ^@ http://purl.uniprot.org/uniprot/G3QPW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/9595:PRKAR2B ^@ http://purl.uniprot.org/uniprot/G3QMV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:PMPCB ^@ http://purl.uniprot.org/uniprot/A0A2I2ZSW3|||http://purl.uniprot.org/uniprot/G3S5I3 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/9595:KCNK4 ^@ http://purl.uniprot.org/uniprot/G3RRZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9595:BTG3 ^@ http://purl.uniprot.org/uniprot/G3S0B1 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9595:GBX2 ^@ http://purl.uniprot.org/uniprot/G3RTW1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:VEGFD ^@ http://purl.uniprot.org/uniprot/G3QJY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDGF/VEGF growth factor family.|||Secreted http://togogenome.org/gene/9595:KITLG ^@ http://purl.uniprot.org/uniprot/G3S4K2|||http://purl.uniprot.org/uniprot/G3S7Q2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCF family.|||Cytoplasm|||Homodimer, non-covalently linked.|||Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.|||Secreted|||filopodium|||lamellipodium http://togogenome.org/gene/9595:RBM5 ^@ http://purl.uniprot.org/uniprot/G3REZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RBM5/RBM10 family.|||Nucleus http://togogenome.org/gene/9595:SERPINF2 ^@ http://purl.uniprot.org/uniprot/G3S7C3 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9595:SVEP1 ^@ http://purl.uniprot.org/uniprot/G3RNE5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9595:DESI1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z916 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/9595:PENK ^@ http://purl.uniprot.org/uniprot/G3RJH3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the opioid neuropeptide precursor family.|||Increases glutamate release in the striatum and decreases GABA concentration in the striatum.|||Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.|||Secreted|||chromaffin granule lumen http://togogenome.org/gene/9595:DENND6A ^@ http://purl.uniprot.org/uniprot/G3SKS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DENND6 family.|||Recycling endosome http://togogenome.org/gene/9595:NKAPL ^@ http://purl.uniprot.org/uniprot/A0A2I2YR21 ^@ Similarity ^@ Belongs to the NKAP family. http://togogenome.org/gene/9595:TMEM98 ^@ http://purl.uniprot.org/uniprot/G3RBY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM98 family.|||Endoplasmic reticulum membrane|||Membrane|||extracellular exosome http://togogenome.org/gene/9595:MCHR2 ^@ http://purl.uniprot.org/uniprot/G3RLV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:SMC1B ^@ http://purl.uniprot.org/uniprot/A0A2I2ZA49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC1 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/9595:MADD ^@ http://purl.uniprot.org/uniprot/A0A2I2YVS3|||http://purl.uniprot.org/uniprot/A0A2I2Z9X1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MADD family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9595:NPHS2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YN39|||http://purl.uniprot.org/uniprot/G3RH62 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/9595:RAD51D ^@ http://purl.uniprot.org/uniprot/G3QDN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.|||Nucleus http://togogenome.org/gene/9595:GNAT3 ^@ http://purl.uniprot.org/uniprot/G3R3M1 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9595:MRPL19 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z2F3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family. http://togogenome.org/gene/9595:NDUFC1 ^@ http://purl.uniprot.org/uniprot/Q0MQF5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFC1 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:WAPL ^@ http://purl.uniprot.org/uniprot/G3S4Q4 ^@ Similarity ^@ Belongs to the WAPL family. http://togogenome.org/gene/9595:CDC20 ^@ http://purl.uniprot.org/uniprot/G3R4G2 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/9595:B3GAT1 ^@ http://purl.uniprot.org/uniprot/G3QIV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:MIGA2 ^@ http://purl.uniprot.org/uniprot/G3RUJ6 ^@ Similarity ^@ Belongs to the mitoguardin family. http://togogenome.org/gene/9595:F2 ^@ http://purl.uniprot.org/uniprot/G3QVP5 ^@ Caution|||Function|||Similarity ^@ Belongs to the peptidase S1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. http://togogenome.org/gene/9595:FAM162B ^@ http://purl.uniprot.org/uniprot/G3QI16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0389 family.|||Membrane http://togogenome.org/gene/9595:PPP1R15B ^@ http://purl.uniprot.org/uniprot/G3QG83 ^@ Similarity ^@ Belongs to the PPP1R15 family. http://togogenome.org/gene/9595:MC5R ^@ http://purl.uniprot.org/uniprot/G3RYK1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins. http://togogenome.org/gene/9595:DPH2 ^@ http://purl.uniprot.org/uniprot/G3S888 ^@ Function|||Similarity ^@ Belongs to the DPH1/DPH2 family. DPH2 subfamily.|||Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit. http://togogenome.org/gene/9595:ARSG ^@ http://purl.uniprot.org/uniprot/G3QG36 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9595:HHATL ^@ http://purl.uniprot.org/uniprot/G3QVU8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:WARS1 ^@ http://purl.uniprot.org/uniprot/G3R3T9 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9595:MC4R ^@ http://purl.uniprot.org/uniprot/G3RGA2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). http://togogenome.org/gene/9595:NQO2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YLC9 ^@ Similarity ^@ Belongs to the NAD(P)H dehydrogenase (quinone) family. http://togogenome.org/gene/9595:LOC101127305 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z4J5 ^@ Similarity ^@ Belongs to the cornifin (SPRR) family. http://togogenome.org/gene/9595:SGTB ^@ http://purl.uniprot.org/uniprot/G3S4B3 ^@ Similarity ^@ Belongs to the SGT family. http://togogenome.org/gene/9595:EPHX1 ^@ http://purl.uniprot.org/uniprot/G3QEY8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S33 family.|||Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9595:LOC101148837 ^@ http://purl.uniprot.org/uniprot/G3S8Y5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:PCLO ^@ http://purl.uniprot.org/uniprot/G3QNK0 ^@ Subcellular Location Annotation ^@ Presynaptic active zone http://togogenome.org/gene/9595:NMU ^@ http://purl.uniprot.org/uniprot/A0A2I2YNU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NmU family.|||Secreted http://togogenome.org/gene/9595:PAH ^@ http://purl.uniprot.org/uniprot/G3S964 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/9595:EXOC6B ^@ http://purl.uniprot.org/uniprot/G3QDX8 ^@ Function|||Similarity ^@ Belongs to the SEC15 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/9595:CUZD1 ^@ http://purl.uniprot.org/uniprot/G3QW82 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:PRPF4 ^@ http://purl.uniprot.org/uniprot/G3QVM3 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/9595:PPM1N ^@ http://purl.uniprot.org/uniprot/G3QCS8 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9595:KATNB1 ^@ http://purl.uniprot.org/uniprot/G3QW37 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat KATNB1 family.|||Cytoplasm|||Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome. This interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein, microtubules, NDEL1 and PAFAH1B1. Interacts with KATNAL1; this interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.|||Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.|||centrosome|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/9595:CSF2 ^@ http://purl.uniprot.org/uniprot/G3QFF8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GM-CSF family.|||Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.|||Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.|||Secreted http://togogenome.org/gene/9595:TMEM225 ^@ http://purl.uniprot.org/uniprot/G3RK89 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:ACAA1 ^@ http://purl.uniprot.org/uniprot/G3QML6 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/9595:KIF20B ^@ http://purl.uniprot.org/uniprot/G3QED3 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9595:TWF1 ^@ http://purl.uniprot.org/uniprot/G3QSD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.|||cytoskeleton http://togogenome.org/gene/9595:LOC101141751 ^@ http://purl.uniprot.org/uniprot/G3RM71 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9595:PREPL ^@ http://purl.uniprot.org/uniprot/G3QWD0 ^@ Similarity ^@ Belongs to the peptidase S9A family. http://togogenome.org/gene/9595:CSNK1E ^@ http://purl.uniprot.org/uniprot/A0A2I2YDN8|||http://purl.uniprot.org/uniprot/A0A2I2ZQ55|||http://purl.uniprot.org/uniprot/G3RJC8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:PTGS2 ^@ http://purl.uniprot.org/uniprot/G3RPV2 ^@ Caution|||Similarity ^@ Belongs to the prostaglandin G/H synthase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:CENPJ ^@ http://purl.uniprot.org/uniprot/G3RF23 ^@ Similarity ^@ Belongs to the TCP10 family. http://togogenome.org/gene/9595:ENDOG ^@ http://purl.uniprot.org/uniprot/G3RE94 ^@ Similarity ^@ Belongs to the DNA/RNA non-specific endonuclease family. http://togogenome.org/gene/9595:COPG1 ^@ http://purl.uniprot.org/uniprot/G3RE83 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPG family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/9595:CLDN14 ^@ http://purl.uniprot.org/uniprot/G3RFZ9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9595:PRKCZ ^@ http://purl.uniprot.org/uniprot/A0A2I2Y2A6|||http://purl.uniprot.org/uniprot/A0A2I2YHG7|||http://purl.uniprot.org/uniprot/G3RB70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily.|||Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cytoplasm http://togogenome.org/gene/9595:SLC39A13 ^@ http://purl.uniprot.org/uniprot/G3S3Y4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:TM4SF20 ^@ http://purl.uniprot.org/uniprot/G3QDH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9595:PRPF4B ^@ http://purl.uniprot.org/uniprot/G3QU86 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.|||Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF. http://togogenome.org/gene/9595:TRAM2 ^@ http://purl.uniprot.org/uniprot/G3R8C8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAM family.|||Membrane http://togogenome.org/gene/9595:CTSH ^@ http://purl.uniprot.org/uniprot/G3R9A7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9595:ZNF711 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z2R9|||http://purl.uniprot.org/uniprot/G3SIY6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:MYH13 ^@ http://purl.uniprot.org/uniprot/G3RCQ6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9595:ACTN3 ^@ http://purl.uniprot.org/uniprot/G3RIU2 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/9595:BMPR2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YY32 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. http://togogenome.org/gene/9595:IL18RAP ^@ http://purl.uniprot.org/uniprot/G3QSS6 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9595:DDX18 ^@ http://purl.uniprot.org/uniprot/G3SEJ0 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9595:GRIN3A ^@ http://purl.uniprot.org/uniprot/G3R217 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9595:REEP4 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZFL5|||http://purl.uniprot.org/uniprot/A0A2I2ZJP1|||http://purl.uniprot.org/uniprot/G3QPB5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:MVD ^@ http://purl.uniprot.org/uniprot/G3R9Z3 ^@ Function|||Similarity ^@ Belongs to the diphosphomevalonate decarboxylase family.|||Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis. http://togogenome.org/gene/9595:SEC23B ^@ http://purl.uniprot.org/uniprot/G3SI15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9595:RRAGD ^@ http://purl.uniprot.org/uniprot/G3RSW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/9595:SASS6 ^@ http://purl.uniprot.org/uniprot/G3QF34 ^@ Subcellular Location Annotation ^@ centrosome http://togogenome.org/gene/9595:SATB1 ^@ http://purl.uniprot.org/uniprot/G3QHC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/9595:DHODH ^@ http://purl.uniprot.org/uniprot/G3RB74 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:HMGB1 ^@ http://purl.uniprot.org/uniprot/G3SGE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/9595:SSBP4 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z4A3|||http://purl.uniprot.org/uniprot/G3RL86 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:CERS2 ^@ http://purl.uniprot.org/uniprot/G3R775 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9595:CCNB2 ^@ http://purl.uniprot.org/uniprot/G3QXD8 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9595:CCDC22 ^@ http://purl.uniprot.org/uniprot/G3QF36 ^@ Similarity ^@ Belongs to the CCDC22 family. http://togogenome.org/gene/9595:GPR61 ^@ http://purl.uniprot.org/uniprot/G3RDT0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:PSME3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z4R3|||http://purl.uniprot.org/uniprot/G3R573 ^@ Similarity ^@ Belongs to the PA28 family. http://togogenome.org/gene/9595:SRPX ^@ http://purl.uniprot.org/uniprot/G3RY54 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:TMEM53 ^@ http://purl.uniprot.org/uniprot/G3QE44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM53 family.|||Membrane|||Nucleus outer membrane http://togogenome.org/gene/9595:LOC101132832 ^@ http://purl.uniprot.org/uniprot/A0A2I2YCH5 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9595:CYGB ^@ http://purl.uniprot.org/uniprot/A0A2I2YA07 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9595:GALNT17 ^@ http://purl.uniprot.org/uniprot/G3QSQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:TOM1L1 ^@ http://purl.uniprot.org/uniprot/G3RLQ6 ^@ Similarity ^@ Belongs to the TOM1 family. http://togogenome.org/gene/9595:LSR ^@ http://purl.uniprot.org/uniprot/A0A2I2ZDH9|||http://purl.uniprot.org/uniprot/G3RQZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. LISCH7 family.|||Membrane|||tight junction http://togogenome.org/gene/9595:GPR142 ^@ http://purl.uniprot.org/uniprot/G3RLJ6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:TMC6 ^@ http://purl.uniprot.org/uniprot/G3QVR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMC family.|||Membrane http://togogenome.org/gene/9595:TIMP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z732 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/9595:LOC101146886 ^@ http://purl.uniprot.org/uniprot/G3R050 ^@ Similarity|||Subunit ^@ Belongs to the GST superfamily. Theta family.|||Homodimer. http://togogenome.org/gene/9595:ITK ^@ http://purl.uniprot.org/uniprot/G3QM29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cytoplasm http://togogenome.org/gene/9595:GRIA4 ^@ http://purl.uniprot.org/uniprot/G3RLF8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9595:FAP ^@ http://purl.uniprot.org/uniprot/G3RGI5 ^@ Subcellular Location Annotation ^@ Cell membrane|||invadopodium membrane|||lamellipodium membrane http://togogenome.org/gene/9595:IFNGR1 ^@ http://purl.uniprot.org/uniprot/G3QZK7 ^@ Similarity ^@ Belongs to the type II cytokine receptor family. http://togogenome.org/gene/9595:EME1 ^@ http://purl.uniprot.org/uniprot/G3R6Q2 ^@ Similarity ^@ Belongs to the EME1/MMS4 family. http://togogenome.org/gene/9595:RASGRP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YWI9|||http://purl.uniprot.org/uniprot/G3RAC5 ^@ Similarity ^@ Belongs to the RASGRP family. http://togogenome.org/gene/9595:MASP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z7G1|||http://purl.uniprot.org/uniprot/G3QFW8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:ANP32E ^@ http://purl.uniprot.org/uniprot/A0A2I2Y1Y2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANP32 family.|||Multifunctional protein that is involved in the regulation of many processes.|||Nucleus http://togogenome.org/gene/9595:PKIG ^@ http://purl.uniprot.org/uniprot/G3RN23 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/9595:MRI1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YEQ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:HOXC4 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z6R8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9595:FGF18 ^@ http://purl.uniprot.org/uniprot/G3QWB5 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9595:UST ^@ http://purl.uniprot.org/uniprot/A0A2I2Z3G8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 3 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:MARS1 ^@ http://purl.uniprot.org/uniprot/G3QHW7 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9595:AGTR2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZVH0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MTUS1.|||Membrane http://togogenome.org/gene/9595:TMEM208 ^@ http://purl.uniprot.org/uniprot/G3QGK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM208 family.|||Endoplasmic reticulum membrane|||May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.|||Membrane http://togogenome.org/gene/9595:DUSP7 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y1Z9 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9595:CASKIN2 ^@ http://purl.uniprot.org/uniprot/G3R1W4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:PCYOX1L ^@ http://purl.uniprot.org/uniprot/G3QRN8 ^@ Similarity ^@ Belongs to the prenylcysteine oxidase family. http://togogenome.org/gene/9595:MTIF2 ^@ http://purl.uniprot.org/uniprot/G3QXH7 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/9595:CSRNP2 ^@ http://purl.uniprot.org/uniprot/G3R4G5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AXUD1 family.|||Nucleus http://togogenome.org/gene/9595:TEX13B ^@ http://purl.uniprot.org/uniprot/G3S1W7 ^@ Similarity ^@ Belongs to the TEX13 family. http://togogenome.org/gene/9595:HADHB ^@ http://purl.uniprot.org/uniprot/G3S6V7 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/9595:LOC101131259 ^@ http://purl.uniprot.org/uniprot/G3S6W7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/9595:RPL8 ^@ http://purl.uniprot.org/uniprot/G3QYP0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/9595:TNFRSF8 ^@ http://purl.uniprot.org/uniprot/G3QXP0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:LAMB3 ^@ http://purl.uniprot.org/uniprot/G3QZE3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:RBP1 ^@ http://purl.uniprot.org/uniprot/G3R9C4 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9595:ADAMTS3 ^@ http://purl.uniprot.org/uniprot/G3QLZ8 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9595:SLC25A13 ^@ http://purl.uniprot.org/uniprot/G3QSP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9595:F2RL2 ^@ http://purl.uniprot.org/uniprot/G3R7Z6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:MYO5B ^@ http://purl.uniprot.org/uniprot/G3QZT8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9595:PARD3B ^@ http://purl.uniprot.org/uniprot/A0A2I2YRT4|||http://purl.uniprot.org/uniprot/G3SKU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAR3 family.|||Cell junction|||Endomembrane system http://togogenome.org/gene/9595:YTHDF1 ^@ http://purl.uniprot.org/uniprot/G3S5K9 ^@ Function|||Similarity ^@ Belongs to the YTHDF family.|||Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. http://togogenome.org/gene/9595:TCN1 ^@ http://purl.uniprot.org/uniprot/G3SJL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic cobalamin transport proteins family.|||Secreted http://togogenome.org/gene/9595:ACOD1 ^@ http://purl.uniprot.org/uniprot/G3RFY3 ^@ Similarity ^@ Belongs to the PrpD family. http://togogenome.org/gene/9595:ADAMTS15 ^@ http://purl.uniprot.org/uniprot/G3QX19 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9595:PSMC6 ^@ http://purl.uniprot.org/uniprot/G3QIB5 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9595:STEAP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZM14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9595:PTPN3 ^@ http://purl.uniprot.org/uniprot/G3RTL6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||May act at junctions between the membrane and the cytoskeleton.|||cytoskeleton http://togogenome.org/gene/9595:WDR35 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZRC1|||http://purl.uniprot.org/uniprot/G3R2V1 ^@ Function|||Subcellular Location Annotation ^@ As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking.|||centrosome|||cilium basal body http://togogenome.org/gene/9595:THRAP3 ^@ http://purl.uniprot.org/uniprot/G3QVJ9 ^@ Similarity ^@ Belongs to the BCLAF1/THRAP3 family. http://togogenome.org/gene/9595:PIWIL4 ^@ http://purl.uniprot.org/uniprot/G3RJJ5 ^@ Similarity ^@ Belongs to the argonaute family. http://togogenome.org/gene/9595:POU3F4 ^@ http://purl.uniprot.org/uniprot/A0A2I2YJ72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-3 subfamily.|||Nucleus http://togogenome.org/gene/9595:ITPRIP ^@ http://purl.uniprot.org/uniprot/A0A2I2ZK90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITPRIP family.|||Membrane http://togogenome.org/gene/9595:SLC15A1 ^@ http://purl.uniprot.org/uniprot/G3RG12 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Interacts (via extracellular domain region) with trypsin.|||Membrane http://togogenome.org/gene/9595:RPL35 ^@ http://purl.uniprot.org/uniprot/G3QNC1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/9595:HOXC6 ^@ http://purl.uniprot.org/uniprot/G3QGY7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:KMT5B ^@ http://purl.uniprot.org/uniprot/A0A2I2ZP50 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus http://togogenome.org/gene/9595:YWHAG ^@ http://purl.uniprot.org/uniprot/G3S848 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9595:MSH2 ^@ http://purl.uniprot.org/uniprot/G3QW00 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA mismatch repair MutS family.|||Component of the post-replicative DNA mismatch repair system (MMR).|||Nucleus http://togogenome.org/gene/9595:RBM3 ^@ http://purl.uniprot.org/uniprot/G3QST9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:NINJ2 ^@ http://purl.uniprot.org/uniprot/G3QJT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ninjurin family.|||Membrane http://togogenome.org/gene/9595:EDNRA ^@ http://purl.uniprot.org/uniprot/G3QEB8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with HDAC7 and KAT5.|||Membrane|||Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. http://togogenome.org/gene/9595:CPLX3 ^@ http://purl.uniprot.org/uniprot/G3QJP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9595:MAP2K6 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZIV3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:PTPRZ1 ^@ http://purl.uniprot.org/uniprot/G3SHA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.|||Membrane http://togogenome.org/gene/9595:LOC101138927 ^@ http://purl.uniprot.org/uniprot/G3QN89 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. http://togogenome.org/gene/9595:WDFY2 ^@ http://purl.uniprot.org/uniprot/G3S422 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9595:CHGB ^@ http://purl.uniprot.org/uniprot/G3QZT1|||http://purl.uniprot.org/uniprot/G3RZN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromogranin/secretogranin protein family.|||Secreted http://togogenome.org/gene/9595:SNX19 ^@ http://purl.uniprot.org/uniprot/G3SCC6 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9595:PTX3 ^@ http://purl.uniprot.org/uniprot/G3RH48 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9595:RPAP2 ^@ http://purl.uniprot.org/uniprot/G3QUX1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD.|||Belongs to the RPAP2 family.|||Nucleus|||Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes. http://togogenome.org/gene/9595:SPTSSB ^@ http://purl.uniprot.org/uniprot/G3S643 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:WDR46 ^@ http://purl.uniprot.org/uniprot/G3QUN1 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9595:IYD ^@ http://purl.uniprot.org/uniprot/A0A2I2YAN4|||http://purl.uniprot.org/uniprot/A0A2I2ZDI2 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9595:CCT6B ^@ http://purl.uniprot.org/uniprot/A0A2I2ZPT1|||http://purl.uniprot.org/uniprot/G3SDV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9595:CCNY ^@ http://purl.uniprot.org/uniprot/A0A2I2YSM3|||http://purl.uniprot.org/uniprot/G3RZR8 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin Y subfamily. http://togogenome.org/gene/9595:B9D2 ^@ http://purl.uniprot.org/uniprot/G3RKC6 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/9595:DIP2A ^@ http://purl.uniprot.org/uniprot/A0A2I2YJC3 ^@ Similarity ^@ Belongs to the DIP2 family. http://togogenome.org/gene/9595:CEMIP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YYM0|||http://purl.uniprot.org/uniprot/G3R3Z3 ^@ Similarity ^@ Belongs to the CEMIP family. http://togogenome.org/gene/9595:CLIC1 ^@ http://purl.uniprot.org/uniprot/G3R6T1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cell membrane|||Cytoplasm|||Endoplasmic reticulum|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane|||Nucleus membrane http://togogenome.org/gene/9595:STS ^@ http://purl.uniprot.org/uniprot/A0A2I2Z9J5 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9595:WASL ^@ http://purl.uniprot.org/uniprot/G3S3Y1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:LOC101129658 ^@ http://purl.uniprot.org/uniprot/G3QY92 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the copper/topaquinone oxidase family.|||Contains 1 topaquinone per subunit.|||Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. http://togogenome.org/gene/9595:NME5 ^@ http://purl.uniprot.org/uniprot/G3QVZ0 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9595:SERPINE2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YS26|||http://purl.uniprot.org/uniprot/G3QF94 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9595:PLXNB1 ^@ http://purl.uniprot.org/uniprot/G3QTS7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the plexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:ECRG4 ^@ http://purl.uniprot.org/uniprot/G3R5Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the augurin family.|||Cytoplasm|||Membrane|||Secreted http://togogenome.org/gene/9595:TSPAN8 ^@ http://purl.uniprot.org/uniprot/G3RKT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9595:DDX3X ^@ http://purl.uniprot.org/uniprot/A0A2I2ZYD9 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9595:LOC101152850 ^@ http://purl.uniprot.org/uniprot/G3S8W7 ^@ Similarity ^@ Belongs to the PRR23 family. http://togogenome.org/gene/9595:TRIM3 ^@ http://purl.uniprot.org/uniprot/G3RBV0 ^@ Similarity ^@ Belongs to the TRIM/RBCC family. http://togogenome.org/gene/9595:ABCB4 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZJ25 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:CD38 ^@ http://purl.uniprot.org/uniprot/G3QTK1 ^@ Similarity ^@ Belongs to the ADP-ribosyl cyclase family. http://togogenome.org/gene/9595:FBXO48 ^@ http://purl.uniprot.org/uniprot/G3QWM8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2.|||Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1. Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway. Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation. http://togogenome.org/gene/9595:SULT1C4 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z451|||http://purl.uniprot.org/uniprot/G3QXV1 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9595:YEATS4 ^@ http://purl.uniprot.org/uniprot/G3RYG4|||http://purl.uniprot.org/uniprot/G3S5K4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:ADHFE1 ^@ http://purl.uniprot.org/uniprot/G3QD50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.|||Mitochondrion http://togogenome.org/gene/9595:SYBU ^@ http://purl.uniprot.org/uniprot/G3QM59 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:GPR3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z3S3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:LY75 ^@ http://purl.uniprot.org/uniprot/G3RVS2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:LPAR6 ^@ http://purl.uniprot.org/uniprot/G3RRG1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:PPCS ^@ http://purl.uniprot.org/uniprot/G3S9J8 ^@ Similarity ^@ Belongs to the PPC synthetase family. http://togogenome.org/gene/9595:UGT3A2 ^@ http://purl.uniprot.org/uniprot/G3QKS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9595:PPP1R16B ^@ http://purl.uniprot.org/uniprot/G3RI06 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:LOC101127763 ^@ http://purl.uniprot.org/uniprot/A4H206 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antimicrobial activity.|||Secreted http://togogenome.org/gene/9595:ANKS1B ^@ http://purl.uniprot.org/uniprot/G3QZC4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:HYCC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YPE8|||http://purl.uniprot.org/uniprot/A0A2I2YR80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Hyccin family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/9595:ODAD4 ^@ http://purl.uniprot.org/uniprot/G3QLZ5 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9595:BARHL1 ^@ http://purl.uniprot.org/uniprot/G3QZ20 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:CASQ2 ^@ http://purl.uniprot.org/uniprot/G3RLH3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calsequestrin family.|||Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.|||Sarcoplasmic reticulum lumen http://togogenome.org/gene/9595:COL4A2 ^@ http://purl.uniprot.org/uniprot/G3RA26 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.|||basement membrane http://togogenome.org/gene/9595:SLC12A8 ^@ http://purl.uniprot.org/uniprot/G3QRX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9595:AK4 ^@ http://purl.uniprot.org/uniprot/G3SGF3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK3 subfamily.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP/ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP/ATP hydrolysis.|||Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.|||Mitochondrion matrix|||Monomer. http://togogenome.org/gene/9595:RGS3 ^@ http://purl.uniprot.org/uniprot/G3S4X9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:MRPS16 ^@ http://purl.uniprot.org/uniprot/G3RGE8 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/9595:ABCA12 ^@ http://purl.uniprot.org/uniprot/G3RZY4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:TNFAIP6 ^@ http://purl.uniprot.org/uniprot/G3S056 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:LOC101143535 ^@ http://purl.uniprot.org/uniprot/G3QIP9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:CD55 ^@ http://purl.uniprot.org/uniprot/G3RY41|||http://purl.uniprot.org/uniprot/G3S1S0|||http://purl.uniprot.org/uniprot/G3SJV6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:ATP5F1C ^@ http://purl.uniprot.org/uniprot/A0A2I2ZNG8|||http://purl.uniprot.org/uniprot/G3R2N5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase gamma chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. http://togogenome.org/gene/9595:MRPS10 ^@ http://purl.uniprot.org/uniprot/G3RAL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS10 family.|||Mitochondrion http://togogenome.org/gene/9595:IPO8 ^@ http://purl.uniprot.org/uniprot/G3S9A6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:UBIAD1 ^@ http://purl.uniprot.org/uniprot/G3QG04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family.|||Membrane http://togogenome.org/gene/9595:SLC25A27 ^@ http://purl.uniprot.org/uniprot/A0A2I2YFM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9595:UGP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZBI4|||http://purl.uniprot.org/uniprot/G3QTW3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDPGP type 1 family.|||Homooctamer.|||UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. http://togogenome.org/gene/9595:YY1 ^@ http://purl.uniprot.org/uniprot/G3S7S5 ^@ Similarity ^@ Belongs to the YY transcription factor family. http://togogenome.org/gene/9595:MYO3A ^@ http://purl.uniprot.org/uniprot/G3QW52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||cytoskeleton http://togogenome.org/gene/9595:UBALD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YYH8 ^@ Similarity ^@ Belongs to the UBALD family. http://togogenome.org/gene/9595:RFC2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z6Y7 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/9595:CFAP97D1 ^@ http://purl.uniprot.org/uniprot/G3RN08 ^@ Similarity ^@ Belongs to the CFAP97 family. http://togogenome.org/gene/9595:SLC5A11 ^@ http://purl.uniprot.org/uniprot/A0A2I2YWT2|||http://purl.uniprot.org/uniprot/G3QH08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:COPS7A ^@ http://purl.uniprot.org/uniprot/G3R1B7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:PPP2CA ^@ http://purl.uniprot.org/uniprot/G3QDL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/9595:PTH2R ^@ http://purl.uniprot.org/uniprot/G3RLB1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:KIF18A ^@ http://purl.uniprot.org/uniprot/G3QE28 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9595:FSHB ^@ http://purl.uniprot.org/uniprot/A0A2K5TIY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/9595:CLCN5 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z3B1 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.|||Cell membrane|||Endosome membrane|||Golgi apparatus membrane|||Interacts with NEDD4 and NEDD4L.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:VMA21 ^@ http://purl.uniprot.org/uniprot/A0A2I2YBK4|||http://purl.uniprot.org/uniprot/G3RHI0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the V0 complex of the vacuolar ATPase (V-ATPase).|||Belongs to the VMA21 family.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum. http://togogenome.org/gene/9595:LPXN ^@ http://purl.uniprot.org/uniprot/G3QHQ4|||http://purl.uniprot.org/uniprot/G3S2X2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the paxillin family.|||Cell membrane|||Cytoplasm|||Nucleus|||The LIM domain 3 is critical for focal adhesion targeting and the suppression of paxillin (PXN) tyrosine phosphorylation. The LIM domain 3 alone or both LIM domains 3 and 4 can mediate interaction with AR.|||Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN).|||focal adhesion|||perinuclear region|||podosome http://togogenome.org/gene/9595:AFF4 ^@ http://purl.uniprot.org/uniprot/G3R7Z9 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/9595:HCAR1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YNR0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:IL18 ^@ http://purl.uniprot.org/uniprot/G3RIH2|||http://purl.uniprot.org/uniprot/G3SF34 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Cytoplasm|||Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.|||Secreted http://togogenome.org/gene/9595:MUL1 ^@ http://purl.uniprot.org/uniprot/G3QUY4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:GPR119 ^@ http://purl.uniprot.org/uniprot/G3S749 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:SCGB2A1 ^@ http://purl.uniprot.org/uniprot/G3SF48 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9595:VAMP3 ^@ http://purl.uniprot.org/uniprot/G3S2Y3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9595:TBX6 ^@ http://purl.uniprot.org/uniprot/A0A2K5TIZ6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9595:NDUFS4 ^@ http://purl.uniprot.org/uniprot/Q0MQH0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS4 subunit family.|||Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme. Interacts with BCAP31 and TOMM40; the interaction mediates its translocation to the mitochondria; the interaction with BCAP31 is direct.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:HSD17B4 ^@ http://purl.uniprot.org/uniprot/A0A2I2YBZ7|||http://purl.uniprot.org/uniprot/G3QHZ6 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/9595:RBL2 ^@ http://purl.uniprot.org/uniprot/G3RZ75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the retinoblastoma protein (RB) family.|||Nucleus http://togogenome.org/gene/9595:PPP1R9B ^@ http://purl.uniprot.org/uniprot/A0A2I2YAH8 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9595:SNTG1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YEY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntrophin family.|||cytoskeleton http://togogenome.org/gene/9595:LAMTOR1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YP21|||http://purl.uniprot.org/uniprot/G3R9U0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR1 family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/9595:C1QBP ^@ http://purl.uniprot.org/uniprot/G3QJU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAM33 family.|||Cell membrane http://togogenome.org/gene/9595:LOC101143363 ^@ http://purl.uniprot.org/uniprot/G3SKW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:NGDN ^@ http://purl.uniprot.org/uniprot/G3QQM9 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9595:ATP2B2 ^@ http://purl.uniprot.org/uniprot/G3R3U8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:NMB ^@ http://purl.uniprot.org/uniprot/G3S1K3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bombesin/neuromedin-B/ranatensin family.|||Secreted|||neuron projection http://togogenome.org/gene/9595:ALKAL2 ^@ http://purl.uniprot.org/uniprot/G3REI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALKAL family.|||Secreted http://togogenome.org/gene/9595:NPPB ^@ http://purl.uniprot.org/uniprot/G3RR78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the natriuretic peptide family.|||Secreted http://togogenome.org/gene/9595:KCNB1 ^@ http://purl.uniprot.org/uniprot/G3QVG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.|||Lateral cell membrane|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synaptic cell membrane|||axon|||dendrite|||sarcolemma|||synaptosome http://togogenome.org/gene/9595:LOC101124358 ^@ http://purl.uniprot.org/uniprot/G3SI34 ^@ Function|||Subunit ^@ In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9595:C6H6orf89 ^@ http://purl.uniprot.org/uniprot/A0A2I2YV80|||http://purl.uniprot.org/uniprot/G3RDJ4 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:MSX1 ^@ http://purl.uniprot.org/uniprot/G3R151 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:GSTO2 ^@ http://purl.uniprot.org/uniprot/G3QED5 ^@ Function|||Similarity ^@ Belongs to the GST superfamily. Omega family.|||Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). http://togogenome.org/gene/9595:SNX21 ^@ http://purl.uniprot.org/uniprot/A0A2I2YZQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome membrane|||Membrane http://togogenome.org/gene/9595:CCR1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZT55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9595:SH2D1A ^@ http://purl.uniprot.org/uniprot/G3SKS3 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. http://togogenome.org/gene/9595:AKAP9 ^@ http://purl.uniprot.org/uniprot/G3QWV6 ^@ Subcellular Location Annotation ^@ centrosome http://togogenome.org/gene/9595:CERS6 ^@ http://purl.uniprot.org/uniprot/A0A2I2YTR2|||http://purl.uniprot.org/uniprot/A0A2I2ZNM1 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9595:DDAH1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z7B9 ^@ Function|||Similarity ^@ Belongs to the DDAH family.|||Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. http://togogenome.org/gene/9595:MALSU1 ^@ http://purl.uniprot.org/uniprot/G3R441 ^@ Similarity ^@ Belongs to the Iojap/RsfS family. http://togogenome.org/gene/9595:SYNGR4 ^@ http://purl.uniprot.org/uniprot/G3SAN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptogyrin family.|||Membrane http://togogenome.org/gene/9595:CD74 ^@ http://purl.uniprot.org/uniprot/G3R7S6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:S100A11 ^@ http://purl.uniprot.org/uniprot/G3R007 ^@ Function|||Similarity|||Subunit ^@ Belongs to the S-100 family.|||Facilitates the differentiation and the cornification of keratinocytes.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9595:ZNRF4 ^@ http://purl.uniprot.org/uniprot/G3QJR4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:CCDC172 ^@ http://purl.uniprot.org/uniprot/G3QNB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC172 family.|||Cytoplasm http://togogenome.org/gene/9595:SPSB3 ^@ http://purl.uniprot.org/uniprot/G3QTS9 ^@ Function|||Similarity ^@ Belongs to the SPSB family.|||May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/9595:DAXX ^@ http://purl.uniprot.org/uniprot/G3SCB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAXX family.|||Cytoplasm|||PML body|||centromere|||nucleolus|||nucleoplasm http://togogenome.org/gene/9595:PTCH1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZGX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the patched family.|||Membrane http://togogenome.org/gene/9595:SCML1 ^@ http://purl.uniprot.org/uniprot/G3QMQ6 ^@ Similarity ^@ Belongs to the SCM family. http://togogenome.org/gene/9595:SCUBE2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z6E5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9595:NAT9 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y9D7|||http://purl.uniprot.org/uniprot/G3QL83 ^@ Similarity ^@ Belongs to the acetyltransferase family. GNAT subfamily. http://togogenome.org/gene/9595:CLCN4 ^@ http://purl.uniprot.org/uniprot/G3R5V0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Membrane http://togogenome.org/gene/9595:ART3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YM94|||http://purl.uniprot.org/uniprot/G3SFL6 ^@ Similarity ^@ Belongs to the Arg-specific ADP-ribosyltransferase family. http://togogenome.org/gene/9595:INSIG2 ^@ http://purl.uniprot.org/uniprot/G3RIH5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INSIG family.|||Endoplasmic reticulum membrane|||Mediates feedback control of cholesterol synthesis.|||Membrane http://togogenome.org/gene/9595:CRYGA ^@ http://purl.uniprot.org/uniprot/G3RM47 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9595:RPS16 ^@ http://purl.uniprot.org/uniprot/G3S6Q1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/9595:RABGGTA ^@ http://purl.uniprot.org/uniprot/A0A2I2ZP66 ^@ Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family.|||Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.|||Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. http://togogenome.org/gene/9595:F9 ^@ http://purl.uniprot.org/uniprot/G3QEB7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9595:RPS6KA2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YGP7|||http://purl.uniprot.org/uniprot/G3SHK7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9595:CACUL1 ^@ http://purl.uniprot.org/uniprot/G3QGH4 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9595:VTI1A ^@ http://purl.uniprot.org/uniprot/A0A2I2ZMC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/9595:CNPY2 ^@ http://purl.uniprot.org/uniprot/G3R152 ^@ Similarity ^@ Belongs to the canopy family. http://togogenome.org/gene/9595:LOC109027173 ^@ http://purl.uniprot.org/uniprot/G3S0N2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:LOC101127306 ^@ http://purl.uniprot.org/uniprot/G3SIN5 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9595:PLAU ^@ http://purl.uniprot.org/uniprot/G3RGY4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:SLC35F6 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z189 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SLC35F solute transporter family.|||Interacts with SLC25A5.|||May play a role as a nucleotide-sugar transporter.|||Membrane|||Mitochondrion http://togogenome.org/gene/9595:SLCO2B1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YC36 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:DSG2 ^@ http://purl.uniprot.org/uniprot/G3S5H2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||desmosome http://togogenome.org/gene/9595:SERP1 ^@ http://purl.uniprot.org/uniprot/G3RR15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAMP4 family.|||Endoplasmic reticulum membrane|||May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.|||Membrane http://togogenome.org/gene/9595:PRKRIP1 ^@ http://purl.uniprot.org/uniprot/G3QXK8 ^@ Similarity ^@ Belongs to the PRKRIP1 family. http://togogenome.org/gene/9595:UBE2F ^@ http://purl.uniprot.org/uniprot/G3R574 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9595:KDM1B ^@ http://purl.uniprot.org/uniprot/G3QLA3 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/9595:CCL13 ^@ http://purl.uniprot.org/uniprot/G3QK67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9595:SLC25A37 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZXB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9595:ADH5 ^@ http://purl.uniprot.org/uniprot/G3RV06 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. http://togogenome.org/gene/9595:CORO1A ^@ http://purl.uniprot.org/uniprot/G3RAD2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat coronin family.|||Binds actin.|||Membrane|||cell cortex|||cytoskeleton|||phagosome membrane http://togogenome.org/gene/9595:NKIRAS1 ^@ http://purl.uniprot.org/uniprot/G3RC04 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. http://togogenome.org/gene/9595:CHRND ^@ http://purl.uniprot.org/uniprot/G3QI64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9595:C4BPB ^@ http://purl.uniprot.org/uniprot/A0A2I2YWR4|||http://purl.uniprot.org/uniprot/G3R971 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:VIPR1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z2U4|||http://purl.uniprot.org/uniprot/G3QNP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:PSMB10 ^@ http://purl.uniprot.org/uniprot/G3RDF2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:RPL27 ^@ http://purl.uniprot.org/uniprot/G3S8W1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL27 family.|||Endoplasmic reticulum|||Rough endoplasmic reticulum http://togogenome.org/gene/9595:DOK2 ^@ http://purl.uniprot.org/uniprot/G3QD93 ^@ Similarity ^@ Belongs to the DOK family. Type A subfamily. http://togogenome.org/gene/9595:NECTIN4 ^@ http://purl.uniprot.org/uniprot/A0A2I2YMG4 ^@ Similarity ^@ Belongs to the nectin family. http://togogenome.org/gene/9595:PER1 ^@ http://purl.uniprot.org/uniprot/G3QSL0 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9595:LOC101143888 ^@ http://purl.uniprot.org/uniprot/G3R150 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9595:GORASP2 ^@ http://purl.uniprot.org/uniprot/G3R9Y6 ^@ Similarity ^@ Belongs to the GORASP family. http://togogenome.org/gene/9595:SLC18A2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZPT5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:PSMD9 ^@ http://purl.uniprot.org/uniprot/G3QVE5 ^@ Similarity ^@ Belongs to the proteasome subunit p27 family. http://togogenome.org/gene/9595:CTSA ^@ http://purl.uniprot.org/uniprot/G3RIP1 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/9595:TNFRSF9 ^@ http://purl.uniprot.org/uniprot/G3RKZ6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:PLPPR4 ^@ http://purl.uniprot.org/uniprot/G3RCC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9595:TINAGL1 ^@ http://purl.uniprot.org/uniprot/G3RS19 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/9595:GNG4 ^@ http://purl.uniprot.org/uniprot/G3QY03 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9595:LOC101143276 ^@ http://purl.uniprot.org/uniprot/G3RL98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:XRCC5 ^@ http://purl.uniprot.org/uniprot/G3R763 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ku80 family.|||Nucleus|||Single-stranded DNA-dependent ATP-dependent helicase. http://togogenome.org/gene/9595:STRADB ^@ http://purl.uniprot.org/uniprot/G3R920 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. http://togogenome.org/gene/9595:SNCB ^@ http://purl.uniprot.org/uniprot/G3RIF1 ^@ Similarity ^@ Belongs to the synuclein family. http://togogenome.org/gene/9595:PDCD10 ^@ http://purl.uniprot.org/uniprot/G3SFY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDCD10 family.|||Cell membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:SWI5 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZG41 ^@ Function|||Similarity ^@ Belongs to the SWI5/SAE3 family.|||Component of the swi5-sfr1 complex, a complex required for double-strand break repair via homologous recombination. http://togogenome.org/gene/9595:SCAMP3 ^@ http://purl.uniprot.org/uniprot/G3R1X9|||http://purl.uniprot.org/uniprot/G3SG04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/9595:TMEM126B ^@ http://purl.uniprot.org/uniprot/G3QI97 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:CRBN ^@ http://purl.uniprot.org/uniprot/A0A2I2YW55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRBN family.|||Nucleus http://togogenome.org/gene/9595:ANXA2 ^@ http://purl.uniprot.org/uniprot/G3S932 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||Membrane|||basement membrane http://togogenome.org/gene/9595:FGFR1 ^@ http://purl.uniprot.org/uniprot/G3RBC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.|||Cell membrane|||Cytoplasmic vesicle|||Membrane|||Nucleus|||Vesicle|||cytosol http://togogenome.org/gene/9595:ADPRH ^@ http://purl.uniprot.org/uniprot/G3QR17 ^@ Similarity ^@ Belongs to the ADP-ribosylglycohydrolase family. http://togogenome.org/gene/9595:OTC ^@ http://purl.uniprot.org/uniprot/G3R7S1 ^@ Similarity|||Subunit ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily.|||Homotrimer. http://togogenome.org/gene/9595:PMVK ^@ http://purl.uniprot.org/uniprot/G3RAP6 ^@ Subcellular Location Annotation ^@ cytosol http://togogenome.org/gene/9595:CALB2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YTV9 ^@ Function|||Similarity ^@ Belongs to the calbindin family.|||Calretinin is a calcium-binding protein which is abundant in auditory neurons. http://togogenome.org/gene/9595:GLB1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZE55 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 35 family. http://togogenome.org/gene/9595:NDUFS1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZR47|||http://purl.uniprot.org/uniprot/Q0MQG1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 75 kDa subunit family.|||Binds 1 [2Fe-2S] cluster per subunit.|||Binds 2 [4Fe-4S] clusters per subunit.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme (By similarity). Complex I associates with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes (By similarity). Interacts with MDM2 and AKAP1 (By similarity).|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (By similarity). Essential for catalysing the entry and efficient transfer of electrons within complex I (By similarity). Plays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes (By similarity).|||Mitochondrion inner membrane http://togogenome.org/gene/9595:DESI2 ^@ http://purl.uniprot.org/uniprot/G3R2V6 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/9595:RICTOR ^@ http://purl.uniprot.org/uniprot/A0A2I2ZHJ0|||http://purl.uniprot.org/uniprot/G3S715 ^@ Similarity ^@ Belongs to the RICTOR family. http://togogenome.org/gene/9595:ATP1A1 ^@ http://purl.uniprot.org/uniprot/G3RZN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:KIT ^@ http://purl.uniprot.org/uniprot/G3RHF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:MGAT4D ^@ http://purl.uniprot.org/uniprot/G3RSK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 54 family.|||Golgi apparatus membrane http://togogenome.org/gene/9595:HMGCS2 ^@ http://purl.uniprot.org/uniprot/G3R459 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family.|||Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. http://togogenome.org/gene/9595:ATAT1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZG01|||http://purl.uniprot.org/uniprot/A0A2I2ZXP3|||http://purl.uniprot.org/uniprot/G3R6S6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Autoacetylation strongly increases tubulin acetylation.|||Belongs to the acetyltransferase ATAT1 family.|||Component of the BBSome complex. Interacts with AP2 alpha-adaptins, including AP2A2, but not with AP1 gamma-adaptin (AP1G1/AP1G2); this interaction is required for efficient alpha-tubulin acetylation, hence clathrin-coated pits are sites of microtubule acetylation.|||Cytoplasm|||Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.|||axon|||clathrin-coated pit|||cytoskeleton|||focal adhesion|||spindle http://togogenome.org/gene/9595:FADD ^@ http://purl.uniprot.org/uniprot/G3RWC4 ^@ Function ^@ Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. http://togogenome.org/gene/9595:TFAP2B ^@ http://purl.uniprot.org/uniprot/G3RF96|||http://purl.uniprot.org/uniprot/G3SBQ3 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/9595:LALBA ^@ http://purl.uniprot.org/uniprot/G3SBC1 ^@ Function|||Similarity ^@ Belongs to the glycosyl hydrolase 22 family.|||Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins. http://togogenome.org/gene/9595:SMARCA5 ^@ http://purl.uniprot.org/uniprot/G3SF21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.|||Nucleus http://togogenome.org/gene/9595:USP37 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZV90 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9595:ZNF394 ^@ http://purl.uniprot.org/uniprot/G3RCS9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:NAXE ^@ http://purl.uniprot.org/uniprot/G3RUT3 ^@ Caution|||Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NnrE/AIBP family.|||Binds 1 potassium ion per subunit.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis.|||Homodimer. Interacts with APOA1 and APOA2.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion|||Secreted|||Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation. http://togogenome.org/gene/9595:LOC101133344 ^@ http://purl.uniprot.org/uniprot/G3RQE4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:TANGO6 ^@ http://purl.uniprot.org/uniprot/G3R3G9 ^@ Similarity ^@ Belongs to the Tango6 family. http://togogenome.org/gene/9595:DCTN6 ^@ http://purl.uniprot.org/uniprot/A0A2I2YXG9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.|||Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.|||cytoskeleton http://togogenome.org/gene/9595:RPL5 ^@ http://purl.uniprot.org/uniprot/G3QJR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL18 family.|||Cytoplasm http://togogenome.org/gene/9595:ATP8B4 ^@ http://purl.uniprot.org/uniprot/G3RQS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9595:DHX15 ^@ http://purl.uniprot.org/uniprot/G3RKY1 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily. http://togogenome.org/gene/9595:CBR1 ^@ http://purl.uniprot.org/uniprot/G3QKD3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9595:LOC101125955 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z7R6 ^@ Similarity ^@ Belongs to the PRR23 family. http://togogenome.org/gene/9595:MYO5C ^@ http://purl.uniprot.org/uniprot/G3RCG3 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9595:PAQR3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YL44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9595:INTS7 ^@ http://purl.uniprot.org/uniprot/G3R8X2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 7 family.|||Nucleus http://togogenome.org/gene/9595:CAPN13 ^@ http://purl.uniprot.org/uniprot/G3RHW3 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9595:SLC26A1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YTK5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane|||Sodium-independent sulfate anion transporter. Can transport other anions including bicarbonate, thiosulfate and oxalate. http://togogenome.org/gene/9595:GAREM1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YBT0 ^@ Similarity ^@ Belongs to the GAREM family. http://togogenome.org/gene/9595:UBE2G1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZY55 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9595:HOXB7 ^@ http://purl.uniprot.org/uniprot/A1YFA5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Antp homeobox family.|||Forms a DNA-binding heterodimer with transcription factor PBX1.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/9595:BBS5 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZW94|||http://purl.uniprot.org/uniprot/G3QRG0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BBS5 family.|||Membrane|||Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10.|||The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.|||centriolar satellite|||cilium membrane http://togogenome.org/gene/9595:LOC101136189 ^@ http://purl.uniprot.org/uniprot/A0A2I2YVA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:MAS1 ^@ http://purl.uniprot.org/uniprot/G3R4L5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:DGKG ^@ http://purl.uniprot.org/uniprot/A0A2I2ZD87|||http://purl.uniprot.org/uniprot/A0A2I2ZRN0 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/9595:NR5A2 ^@ http://purl.uniprot.org/uniprot/G3R3Z2|||http://purl.uniprot.org/uniprot/G3S1U1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR5 subfamily.|||Nucleus http://togogenome.org/gene/9595:AFMID ^@ http://purl.uniprot.org/uniprot/G3QVU4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kynurenine formamidase family.|||Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.|||Homodimer.|||Nucleus|||The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.|||cytosol http://togogenome.org/gene/9595:GRM4 ^@ http://purl.uniprot.org/uniprot/G3QRF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:RPS18 ^@ http://purl.uniprot.org/uniprot/G3QUM7 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Component of the small ribosomal subunit. http://togogenome.org/gene/9595:SCAMP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YV30|||http://purl.uniprot.org/uniprot/A0A2I2ZS17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/9595:MINAR1 ^@ http://purl.uniprot.org/uniprot/G3R9M4 ^@ Similarity ^@ Belongs to the MINAR family. http://togogenome.org/gene/9595:LOC101131103 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZDJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:SH2B3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z002 ^@ Similarity ^@ Belongs to the SH2B adapter family. http://togogenome.org/gene/9595:MED9 ^@ http://purl.uniprot.org/uniprot/G3R6K1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 9 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9595:ZHX3 ^@ http://purl.uniprot.org/uniprot/G3R023 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZHX family.|||Nucleus http://togogenome.org/gene/9595:RFTN2 ^@ http://purl.uniprot.org/uniprot/G3R1M3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the raftlin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:USP30 ^@ http://purl.uniprot.org/uniprot/G3R2E3 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9595:DERL1 ^@ http://purl.uniprot.org/uniprot/G3R0M4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Membrane http://togogenome.org/gene/9595:GHITM ^@ http://purl.uniprot.org/uniprot/G3R5Z5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9595:MAK16 ^@ http://purl.uniprot.org/uniprot/G3R4M4 ^@ Similarity ^@ Belongs to the MAK16 family. http://togogenome.org/gene/9595:BGN ^@ http://purl.uniprot.org/uniprot/G3QWA4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||May be involved in collagen fiber assembly.|||extracellular matrix http://togogenome.org/gene/9595:TGFB3 ^@ http://purl.uniprot.org/uniprot/G3QGK3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.|||extracellular matrix http://togogenome.org/gene/9595:SLC25A23 ^@ http://purl.uniprot.org/uniprot/G3S9R4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9595:BTF3 ^@ http://purl.uniprot.org/uniprot/G3QD56 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/9595:KXD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y232 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KXD1 family.|||Lysosome membrane http://togogenome.org/gene/9595:SPNS2 ^@ http://purl.uniprot.org/uniprot/G3RX14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.|||Membrane http://togogenome.org/gene/9595:SCRN3 ^@ http://purl.uniprot.org/uniprot/G3SKU3 ^@ Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily. http://togogenome.org/gene/9595:EPHA3 ^@ http://purl.uniprot.org/uniprot/G3RG43 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:RCAN2 ^@ http://purl.uniprot.org/uniprot/G3QPS7|||http://purl.uniprot.org/uniprot/G3S776 ^@ Function|||Similarity ^@ Belongs to the RCAN family.|||Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. http://togogenome.org/gene/9595:POSTN ^@ http://purl.uniprot.org/uniprot/A0A2I2YTD4|||http://purl.uniprot.org/uniprot/A0A2I2YVT8|||http://purl.uniprot.org/uniprot/A0A2I2ZP34|||http://purl.uniprot.org/uniprot/G3QUZ5 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9595:GMPPA ^@ http://purl.uniprot.org/uniprot/G3SHF2 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/9595:BRPF1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZS35|||http://purl.uniprot.org/uniprot/G3REC3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:EXOC4 ^@ http://purl.uniprot.org/uniprot/G3QMY0 ^@ Function|||Similarity ^@ Belongs to the SEC8 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/9595:CDC26 ^@ http://purl.uniprot.org/uniprot/G3R308 ^@ Function|||Similarity ^@ Belongs to the CDC26 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. http://togogenome.org/gene/9595:NDUFA8 ^@ http://purl.uniprot.org/uniprot/Q0MQB0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA8 subunit family.|||Complex I is composed of 45 different subunits.|||Contains four C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds.|||Mitochondrion|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/9595:POLR2C ^@ http://purl.uniprot.org/uniprot/G3RTN0 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/9595:FGF9 ^@ http://purl.uniprot.org/uniprot/G3QQL4 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9595:C2AH2orf49 ^@ http://purl.uniprot.org/uniprot/G3S591 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ashwin family.|||Nucleus http://togogenome.org/gene/9595:POLR3C ^@ http://purl.uniprot.org/uniprot/G3QWH0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/9595:LOC101123691 ^@ http://purl.uniprot.org/uniprot/G3R4Z9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:MFSD9 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZMH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/9595:CXCL6 ^@ http://purl.uniprot.org/uniprot/G3R3B6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9595:MRPS11 ^@ http://purl.uniprot.org/uniprot/G3RGN4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/9595:LOC101138067 ^@ http://purl.uniprot.org/uniprot/G3RFI9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9595:LDLRAD4 ^@ http://purl.uniprot.org/uniprot/A0A2I2YGK7|||http://purl.uniprot.org/uniprot/A0A2I2YS19|||http://purl.uniprot.org/uniprot/G3RCG1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMEPA1 family.|||Early endosome membrane|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:GAB3 ^@ http://purl.uniprot.org/uniprot/G3QFF6 ^@ Similarity ^@ Belongs to the GAB family. http://togogenome.org/gene/9595:CILP ^@ http://purl.uniprot.org/uniprot/A0A2I2YZ36 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9595:ANO10 ^@ http://purl.uniprot.org/uniprot/G3RE27 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:HR ^@ http://purl.uniprot.org/uniprot/G3QPB1|||http://purl.uniprot.org/uniprot/G3RZX8 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the JHDM2 histone demethylase family.|||Binds 1 Fe(2+) ion per subunit.|||Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.|||Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.|||Nucleus|||The JmjC domain and the C6-type zinc-finger are required for the demethylation activity. http://togogenome.org/gene/9595:DLGAP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YGA1|||http://purl.uniprot.org/uniprot/A0A2I2YVL4|||http://purl.uniprot.org/uniprot/A0A2I2ZKN2|||http://purl.uniprot.org/uniprot/G3SKG4 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/9595:TBL3 ^@ http://purl.uniprot.org/uniprot/G3R1T7 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9595:ARSK ^@ http://purl.uniprot.org/uniprot/G3QSM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Lysosome http://togogenome.org/gene/9595:MLF1 ^@ http://purl.uniprot.org/uniprot/G3S8S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MLF family.|||Cytoplasm http://togogenome.org/gene/9595:SHROOM4 ^@ http://purl.uniprot.org/uniprot/A0A2I2YGZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shroom family.|||cytoskeleton http://togogenome.org/gene/9595:PTCD3 ^@ http://purl.uniprot.org/uniprot/G3QHE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS39 family.|||Mitochondrion http://togogenome.org/gene/9595:TCP10L ^@ http://purl.uniprot.org/uniprot/A0A2I2Y236 ^@ Similarity ^@ Belongs to the TCP10 family. http://togogenome.org/gene/9595:SLC6A2 ^@ http://purl.uniprot.org/uniprot/G3QR21|||http://purl.uniprot.org/uniprot/G3RMU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9595:LTBP2 ^@ http://purl.uniprot.org/uniprot/G3SCK9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9595:ATL3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZNA4 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9595:PAX9 ^@ http://purl.uniprot.org/uniprot/G3QGP5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:GPR155 ^@ http://purl.uniprot.org/uniprot/G3SBT6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:SNX30 ^@ http://purl.uniprot.org/uniprot/G3QNL2 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9595:KCND2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YDN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.|||Cell junction|||Cell membrane|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane|||dendrite|||dendritic spine http://togogenome.org/gene/9595:SCG5 ^@ http://purl.uniprot.org/uniprot/G3RJS1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.|||Belongs to the 7B2 family.|||Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.|||Secreted http://togogenome.org/gene/9595:LDB2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZYG9 ^@ Similarity ^@ Belongs to the LDB family. http://togogenome.org/gene/9595:TRIM54 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z362 ^@ Function|||Subcellular Location Annotation ^@ May bind and stabilize microtubules during myotubes formation.|||Z line http://togogenome.org/gene/9595:SESN1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YZC4|||http://purl.uniprot.org/uniprot/G3QYS2|||http://purl.uniprot.org/uniprot/G3RU39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/9595:PTGES ^@ http://purl.uniprot.org/uniprot/A0A2I2YMC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Membrane http://togogenome.org/gene/9595:DCP1B ^@ http://purl.uniprot.org/uniprot/G3S7W5 ^@ Similarity ^@ Belongs to the DCP1 family. http://togogenome.org/gene/9595:APAF1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YKE3|||http://purl.uniprot.org/uniprot/A0A2I2ZPS0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Monomer. Oligomerizes upon binding of cytochrome c and dATP.|||Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. http://togogenome.org/gene/9595:CALY ^@ http://purl.uniprot.org/uniprot/G3QT06 ^@ Similarity ^@ Belongs to the NSG family. http://togogenome.org/gene/9595:LOC101127832 ^@ http://purl.uniprot.org/uniprot/G3R1D0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:PPA1 ^@ http://purl.uniprot.org/uniprot/G3RLE5 ^@ Similarity ^@ Belongs to the PPase family. http://togogenome.org/gene/9595:ZSCAN21 ^@ http://purl.uniprot.org/uniprot/G3R736 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:VAMP8 ^@ http://purl.uniprot.org/uniprot/G3QQI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9595:RXRB ^@ http://purl.uniprot.org/uniprot/G3R2Y5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Nucleus http://togogenome.org/gene/9595:POLR2F ^@ http://purl.uniprot.org/uniprot/A0A2I2ZC79 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.|||Nucleus http://togogenome.org/gene/9595:RNF170 ^@ http://purl.uniprot.org/uniprot/G3QQE5 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:NSDHL ^@ http://purl.uniprot.org/uniprot/G3RLK2 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9595:SF3A1 ^@ http://purl.uniprot.org/uniprot/G3RA68 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:RAP1GDS1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YZK7|||http://purl.uniprot.org/uniprot/G3QPH3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum|||Mitochondrion http://togogenome.org/gene/9595:CCNG2 ^@ http://purl.uniprot.org/uniprot/G3RRB1 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9595:LRRC8C ^@ http://purl.uniprot.org/uniprot/G3SFV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:RNASEH2B ^@ http://purl.uniprot.org/uniprot/A0A2I2YP62|||http://purl.uniprot.org/uniprot/G3QFF7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase H2 subunit B family.|||Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.|||Nucleus|||The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C. http://togogenome.org/gene/9595:LOC101129673 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZTX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ADAMTS2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YQ87 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:OS9 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZSU4|||http://purl.uniprot.org/uniprot/G3QGC5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OS-9 family.|||Endoplasmic reticulum lumen|||Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation. http://togogenome.org/gene/9595:ZNF215 ^@ http://purl.uniprot.org/uniprot/G3QMM6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:UTRN ^@ http://purl.uniprot.org/uniprot/G3S2D7 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9595:TAAR1 ^@ http://purl.uniprot.org/uniprot/G3RZ14 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:LYZL6 ^@ http://purl.uniprot.org/uniprot/G3R4J6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9595:GSX2 ^@ http://purl.uniprot.org/uniprot/G3QY28 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SLC35B4 ^@ http://purl.uniprot.org/uniprot/G3QH86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/9595:IDH3B ^@ http://purl.uniprot.org/uniprot/G3R3G3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.|||Mitochondrion http://togogenome.org/gene/9595:ZNF280C ^@ http://purl.uniprot.org/uniprot/G3RMJ0 ^@ Function|||Subcellular Location Annotation ^@ May function as a transcription factor.|||Nucleus http://togogenome.org/gene/9595:CTNNBL1 ^@ http://purl.uniprot.org/uniprot/G3QEB4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:ITGA3 ^@ http://purl.uniprot.org/uniprot/G3RCK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9595:LOC101134092 ^@ http://purl.uniprot.org/uniprot/G3SET6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9595:STK38L ^@ http://purl.uniprot.org/uniprot/G3QHG5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:FZD7 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZTF8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:SGCE ^@ http://purl.uniprot.org/uniprot/A0A2I2YDG7|||http://purl.uniprot.org/uniprot/A0A2I2Z2X0|||http://purl.uniprot.org/uniprot/G3QKY4 ^@ Function|||Similarity ^@ Belongs to the sarcoglycan alpha/epsilon family.|||Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. http://togogenome.org/gene/9595:EIF4A3 ^@ http://purl.uniprot.org/uniprot/G3RAX3 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9595:HIF1A ^@ http://purl.uniprot.org/uniprot/A0A2I2ZEQ0 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus speckle http://togogenome.org/gene/9595:CDH11 ^@ http://purl.uniprot.org/uniprot/G3QKI4 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:RSPO3 ^@ http://purl.uniprot.org/uniprot/G3SBH2 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/9595:DDX5 ^@ http://purl.uniprot.org/uniprot/G3RHC7 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily. http://togogenome.org/gene/9595:MMP26 ^@ http://purl.uniprot.org/uniprot/G3R6L8 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9595:SYT2 ^@ http://purl.uniprot.org/uniprot/G3QPB7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.|||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.|||synaptic vesicle membrane http://togogenome.org/gene/9595:ORC1 ^@ http://purl.uniprot.org/uniprot/G3QMW4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC1 family.|||Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with CDC6 and KAT7/HBO1. Interacts with LRWD1 predominantly during the G1 phase and with less affinity during mitosis, when phosphorylated.|||Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.|||Nucleus http://togogenome.org/gene/9595:DYNLT1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YU98 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/9595:TTR ^@ http://purl.uniprot.org/uniprot/G3S3S9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transthyretin family.|||Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4.|||Secreted|||Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. http://togogenome.org/gene/9595:TP53I11 ^@ http://purl.uniprot.org/uniprot/A0A2I2YBP2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:RPL36A ^@ http://purl.uniprot.org/uniprot/G3R205 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/9595:IER3IP1 ^@ http://purl.uniprot.org/uniprot/G3RM54 ^@ Similarity ^@ Belongs to the YOS1 family. http://togogenome.org/gene/9595:HS2ST1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YUR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 3 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:CCL28 ^@ http://purl.uniprot.org/uniprot/A0A2I2YCD7|||http://purl.uniprot.org/uniprot/G3RAN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9595:SYN1 ^@ http://purl.uniprot.org/uniprot/G3R034 ^@ Similarity ^@ Belongs to the synapsin family. http://togogenome.org/gene/9595:CD14 ^@ http://purl.uniprot.org/uniprot/G3R4C0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Interacts with LPAR1.|||Cell membrane|||Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).|||Golgi apparatus|||Membrane raft|||Secreted http://togogenome.org/gene/9595:CALCB ^@ http://purl.uniprot.org/uniprot/A0A2I2ZIT6 ^@ Similarity ^@ Belongs to the calcitonin family. http://togogenome.org/gene/9595:PRPF19 ^@ http://purl.uniprot.org/uniprot/G3QZY5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat PRP19 family.|||Homotetramer.|||Lipid droplet|||Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.|||nucleoplasm http://togogenome.org/gene/9595:FNTB ^@ http://purl.uniprot.org/uniprot/G3R1C3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the protein prenyltransferase subunit beta family.|||Binds 1 zinc ion per subunit.|||Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.|||Heterodimer of FNTA and FNTB. http://togogenome.org/gene/9595:ZSCAN10 ^@ http://purl.uniprot.org/uniprot/G3R7W9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SULF1 ^@ http://purl.uniprot.org/uniprot/G3R9R9 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Binds 1 Ca(2+) ion per subunit.|||Cell surface|||Endoplasmic reticulum|||Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.|||Golgi stack|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9595:PDP2 ^@ http://purl.uniprot.org/uniprot/G3S0L5 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9595:TEKT2 ^@ http://purl.uniprot.org/uniprot/G3QMF8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/9595:NDUFV2 ^@ http://purl.uniprot.org/uniprot/Q0MQI8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme (By similarity).|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:KIAA2013 ^@ http://purl.uniprot.org/uniprot/G3SEG6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:PSMC4 ^@ http://purl.uniprot.org/uniprot/G3QF43 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9595:PAX4 ^@ http://purl.uniprot.org/uniprot/G3RZS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/9595:PROC ^@ http://purl.uniprot.org/uniprot/G3RJ40 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9595:LOC101153433 ^@ http://purl.uniprot.org/uniprot/G3QZR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:TNNT3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YJ48 ^@ Function|||Similarity ^@ Belongs to the troponin T family.|||Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. http://togogenome.org/gene/9595:CS ^@ http://purl.uniprot.org/uniprot/G3S3T6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the citrate synthase family.|||Homodimer.|||Mitochondrion matrix http://togogenome.org/gene/9595:SERPINI1 ^@ http://purl.uniprot.org/uniprot/G3QDF4 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9595:SNX33 ^@ http://purl.uniprot.org/uniprot/G3RIR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane http://togogenome.org/gene/9595:HOPX ^@ http://purl.uniprot.org/uniprot/G3RUB5|||http://purl.uniprot.org/uniprot/G3SAU5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SDR9C7 ^@ http://purl.uniprot.org/uniprot/G3QYD0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9595:PRR15L ^@ http://purl.uniprot.org/uniprot/A0A2I2ZIQ4 ^@ Similarity ^@ Belongs to the PRR15 family. http://togogenome.org/gene/9595:EIF4G1 ^@ http://purl.uniprot.org/uniprot/G3RDI1 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4G family. http://togogenome.org/gene/9595:VRK1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y8N8|||http://purl.uniprot.org/uniprot/G3QNA2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:CDKN2AIP ^@ http://purl.uniprot.org/uniprot/G3S5R6 ^@ Similarity ^@ Belongs to the CARF family. http://togogenome.org/gene/9595:SLCO4C1 ^@ http://purl.uniprot.org/uniprot/G3RSC6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:HPGD ^@ http://purl.uniprot.org/uniprot/G3R336 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9595:BNIP3L ^@ http://purl.uniprot.org/uniprot/A0A2I2ZVP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIP3 family.|||Membrane http://togogenome.org/gene/9595:ATAD1 ^@ http://purl.uniprot.org/uniprot/G3S3I4 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9595:HMGB3 ^@ http://purl.uniprot.org/uniprot/G3S2A5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/9595:MAP4K3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YV02|||http://purl.uniprot.org/uniprot/G3RY59 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. http://togogenome.org/gene/9595:RDH11 ^@ http://purl.uniprot.org/uniprot/G3QS80 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9595:CHMP2B ^@ http://purl.uniprot.org/uniprot/G3SJW8 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9595:LOC101135415 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y4B6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:PODXL ^@ http://purl.uniprot.org/uniprot/A0A2I2ZUH8|||http://purl.uniprot.org/uniprot/G3QEY9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the podocalyxin family.|||Cell membrane|||Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.|||Membrane|||Membrane raft|||filopodium|||lamellipodium|||microvillus|||ruffle http://togogenome.org/gene/9595:HSPD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZC23 ^@ Similarity ^@ Belongs to the chaperonin (HSP60) family. http://togogenome.org/gene/9595:PLPP5 ^@ http://purl.uniprot.org/uniprot/A0A2I2YC75|||http://purl.uniprot.org/uniprot/A0A2I2ZNN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9595:ACP7 ^@ http://purl.uniprot.org/uniprot/G3R6I6 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family. http://togogenome.org/gene/9595:LGI3 ^@ http://purl.uniprot.org/uniprot/G3QEW7 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9595:TMTC2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YJ53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/9595:SLC6A15 ^@ http://purl.uniprot.org/uniprot/G3R4I3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A15 subfamily.|||Membrane http://togogenome.org/gene/9595:SESN2 ^@ http://purl.uniprot.org/uniprot/G3REY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/9595:KAT2A ^@ http://purl.uniprot.org/uniprot/G3QRU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. GCN5 subfamily.|||Nucleus|||centrosome http://togogenome.org/gene/9595:SLC23A3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YAN7|||http://purl.uniprot.org/uniprot/G3R5I1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:LOC101140641 ^@ http://purl.uniprot.org/uniprot/G3R516 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MHC class I family.|||Belongs to the MHC class II family.|||Endosome membrane|||Lysosome membrane http://togogenome.org/gene/9595:FERMT3 ^@ http://purl.uniprot.org/uniprot/G3R8Y5 ^@ Similarity ^@ Belongs to the kindlin family. http://togogenome.org/gene/9595:MED18 ^@ http://purl.uniprot.org/uniprot/G3QX56 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 18 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9595:LOC101124697 ^@ http://purl.uniprot.org/uniprot/G3QUH6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).|||Belongs to the cytochrome P450 family.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:AIDA ^@ http://purl.uniprot.org/uniprot/G3RH02 ^@ Similarity ^@ Belongs to the AIDA family. http://togogenome.org/gene/9595:DUSP6 ^@ http://purl.uniprot.org/uniprot/G3SCU3 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9595:KIF22 ^@ http://purl.uniprot.org/uniprot/A0A2I2YSQ9 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9595:EIF2AK3 ^@ http://purl.uniprot.org/uniprot/G3R7Z1 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9595:LCMT1 ^@ http://purl.uniprot.org/uniprot/G3QYE2 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. LCMT family.|||Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. http://togogenome.org/gene/9595:LHX8 ^@ http://purl.uniprot.org/uniprot/G3RXH8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:GTDC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YQ62|||http://purl.uniprot.org/uniprot/G3RI96 ^@ Similarity ^@ Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. http://togogenome.org/gene/9595:FBXO25 ^@ http://purl.uniprot.org/uniprot/G3S6L8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:AQP2 ^@ http://purl.uniprot.org/uniprot/G3QSX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9595:BMP15 ^@ http://purl.uniprot.org/uniprot/G3QUI0 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9595:MRPL2 ^@ http://purl.uniprot.org/uniprot/G3R4S7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/9595:MTMR9 ^@ http://purl.uniprot.org/uniprot/G3RJI2 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9595:PTN ^@ http://purl.uniprot.org/uniprot/G3RUP5 ^@ Similarity ^@ Belongs to the pleiotrophin family. http://togogenome.org/gene/9595:SLC39A6 ^@ http://purl.uniprot.org/uniprot/G3R4A7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:CXCL8 ^@ http://purl.uniprot.org/uniprot/G3SA80 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Homodimer.|||Secreted http://togogenome.org/gene/9595:LOC101133882 ^@ http://purl.uniprot.org/uniprot/G3RQ76 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9595:RPS3 ^@ http://purl.uniprot.org/uniprot/G3QUH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS3 family.|||Membrane|||Mitochondrion inner membrane|||spindle http://togogenome.org/gene/9595:FAM241A ^@ http://purl.uniprot.org/uniprot/G3RQY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM241 family.|||Membrane http://togogenome.org/gene/9595:ZDHHC3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YYI8|||http://purl.uniprot.org/uniprot/A0A2I2ZUD4|||http://purl.uniprot.org/uniprot/G3RCD2|||http://purl.uniprot.org/uniprot/G3SAX1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9595:PIK3CD ^@ http://purl.uniprot.org/uniprot/A0A2I2ZMF3 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9595:NIPSNAP3A ^@ http://purl.uniprot.org/uniprot/G3R4G4 ^@ Similarity ^@ Belongs to the NipSnap family. http://togogenome.org/gene/9595:BACE1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZA05|||http://purl.uniprot.org/uniprot/A0A2I2ZRA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Endosome|||Membrane|||Membrane raft|||Recycling endosome|||trans-Golgi network http://togogenome.org/gene/9595:GPRASP2 ^@ http://purl.uniprot.org/uniprot/G3RVY3 ^@ Similarity ^@ Belongs to the GPRASP family. http://togogenome.org/gene/9595:GALNT14 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z3V9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:CRB1 ^@ http://purl.uniprot.org/uniprot/G3RZV2|||http://purl.uniprot.org/uniprot/G3SK60 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:LACTB2 ^@ http://purl.uniprot.org/uniprot/G3SGF8 ^@ Function|||Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.|||Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability. http://togogenome.org/gene/9595:CALR3 ^@ http://purl.uniprot.org/uniprot/G3SIG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calreticulin family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9595:ABRAXAS2 ^@ http://purl.uniprot.org/uniprot/G3RDS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM175 family. Abro1 subfamily.|||Nucleus|||spindle pole http://togogenome.org/gene/9595:AMPD2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YTI3|||http://purl.uniprot.org/uniprot/G3RBY5 ^@ Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.|||Homotetramer. http://togogenome.org/gene/9595:APOB ^@ http://purl.uniprot.org/uniprot/G3QR49 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:MRPS17 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y3N5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/9595:SLC37A3 ^@ http://purl.uniprot.org/uniprot/G3S227 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Membrane http://togogenome.org/gene/9595:TM6SF2 ^@ http://purl.uniprot.org/uniprot/G3QKG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TM6SF family.|||Membrane http://togogenome.org/gene/9595:GK3 ^@ http://purl.uniprot.org/uniprot/G3S3A7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FGGY kinase family.|||Cytoplasm http://togogenome.org/gene/9595:SMIM5 ^@ http://purl.uniprot.org/uniprot/G3R235 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:IPO9 ^@ http://purl.uniprot.org/uniprot/G3QV84 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:UNC13D ^@ http://purl.uniprot.org/uniprot/G3SJT8 ^@ Similarity ^@ Belongs to the unc-13 family. http://togogenome.org/gene/9595:POLR1B ^@ http://purl.uniprot.org/uniprot/G3RCD9 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft. http://togogenome.org/gene/9595:HAO1 ^@ http://purl.uniprot.org/uniprot/G3QNZ8 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/9595:CPXM1 ^@ http://purl.uniprot.org/uniprot/G3QXL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||Secreted http://togogenome.org/gene/9595:KCNQ1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YY26 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.1/KCNQ1 sub-subfamily.|||Cell membrane|||Cytoplasmic vesicle membrane|||Endoplasmic reticulum|||Lateral cell membrane|||Membrane|||Membrane raft http://togogenome.org/gene/9595:RPL4 ^@ http://purl.uniprot.org/uniprot/G3QMA1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL4 family. http://togogenome.org/gene/9595:STK17B ^@ http://purl.uniprot.org/uniprot/G3RKZ0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:HIGD1C ^@ http://purl.uniprot.org/uniprot/G3R9D1 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/9595:OLFM2 ^@ http://purl.uniprot.org/uniprot/G3QT74 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/9595:TM4SF1 ^@ http://purl.uniprot.org/uniprot/G3QM18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9595:PRKAA1 ^@ http://purl.uniprot.org/uniprot/G3RWH8|||http://purl.uniprot.org/uniprot/G3RZF9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. http://togogenome.org/gene/9595:CDKAL1 ^@ http://purl.uniprot.org/uniprot/G3QPG1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methylthiotransferase family. CDKAL1 subfamily.|||Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9595:STARD3NL ^@ http://purl.uniprot.org/uniprot/A0A2I2ZEJ6|||http://purl.uniprot.org/uniprot/G3RCB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STARD3 family.|||Membrane http://togogenome.org/gene/9595:LOC101127528 ^@ http://purl.uniprot.org/uniprot/G3RYN3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCRB/QCR7 family.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:DOP1A ^@ http://purl.uniprot.org/uniprot/G3QDW5|||http://purl.uniprot.org/uniprot/G3S5F3 ^@ Similarity ^@ Belongs to the dopey family. http://togogenome.org/gene/9595:SEMA3G ^@ http://purl.uniprot.org/uniprot/G3RIL7 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:SPRING1 ^@ http://purl.uniprot.org/uniprot/G3RI24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPRING family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:RAB3C ^@ http://purl.uniprot.org/uniprot/G3RCG9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/9595:F3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YXP6|||http://purl.uniprot.org/uniprot/G3RFF8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tissue factor family.|||Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.|||Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.|||Membrane http://togogenome.org/gene/9595:LOC101133995 ^@ http://purl.uniprot.org/uniprot/G3RX38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MHC class I family.|||Belongs to the MHC class II family.|||Endosome membrane|||Lysosome membrane http://togogenome.org/gene/9595:DMTN ^@ http://purl.uniprot.org/uniprot/G3SJV3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:ABCC2 ^@ http://purl.uniprot.org/uniprot/G3RQL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:PMM2 ^@ http://purl.uniprot.org/uniprot/G3R3Q1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic PMM family.|||Cytoplasm|||Homodimer.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/9595:CRMP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YKJ4 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/9595:CAMK2D ^@ http://purl.uniprot.org/uniprot/A0A2I2YPU1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9595:ATF7IP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YGC2|||http://purl.uniprot.org/uniprot/A0A2I2ZNP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCAF family.|||Nucleus http://togogenome.org/gene/9595:CDX2 ^@ http://purl.uniprot.org/uniprot/G3SJL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Caudal homeobox family.|||Nucleus http://togogenome.org/gene/9595:WDR76 ^@ http://purl.uniprot.org/uniprot/G3QTT5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the WD repeat DDB2/WDR76 family.|||Interacts with CUL4A and/or CUL4B.|||Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. http://togogenome.org/gene/9595:TAGLN3 ^@ http://purl.uniprot.org/uniprot/G3RJS5 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/9595:HOXC5 ^@ http://purl.uniprot.org/uniprot/G3QGY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9595:CHRNB3 ^@ http://purl.uniprot.org/uniprot/G3RJI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9595:ZSCAN16 ^@ http://purl.uniprot.org/uniprot/G3RXS8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:ELAVL1 ^@ http://purl.uniprot.org/uniprot/G3S707 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM elav family.|||Cytoplasm http://togogenome.org/gene/9595:CLDN18 ^@ http://purl.uniprot.org/uniprot/G3RCR4|||http://purl.uniprot.org/uniprot/G3S9A3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9595:DGAT2 ^@ http://purl.uniprot.org/uniprot/G3QK91 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:VARS2 ^@ http://purl.uniprot.org/uniprot/G3RF77 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9595:NIF3L1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YIR4|||http://purl.uniprot.org/uniprot/G3RDV2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family.|||Cytoplasm|||Homodimer. Interacts with COPS2. Interacts with THOC7.|||May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.|||Nucleus http://togogenome.org/gene/9595:LHX4 ^@ http://purl.uniprot.org/uniprot/G3RTM0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:C1H1orf52 ^@ http://purl.uniprot.org/uniprot/A0A2I2YFI8 ^@ Similarity ^@ Belongs to the UPF0690 family. http://togogenome.org/gene/9595:CHRM1 ^@ http://purl.uniprot.org/uniprot/G3RJP5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. http://togogenome.org/gene/9595:ABCB7 ^@ http://purl.uniprot.org/uniprot/G3RI18 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:VDAC3 ^@ http://purl.uniprot.org/uniprot/G3RV76 ^@ Similarity ^@ Belongs to the eukaryotic mitochondrial porin family. http://togogenome.org/gene/9595:ABLIM3 ^@ http://purl.uniprot.org/uniprot/G3QRM3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:AP3B1 ^@ http://purl.uniprot.org/uniprot/G3RU11 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes large subunit family.|||Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9595:LOC101129097 ^@ http://purl.uniprot.org/uniprot/G3S1W5 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9595:LOC101145461 ^@ http://purl.uniprot.org/uniprot/G3RIY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NXF family.|||Cytoplasm http://togogenome.org/gene/9595:ALG10B ^@ http://purl.uniprot.org/uniprot/G3QZC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG10 glucosyltransferase family.|||Membrane http://togogenome.org/gene/9595:C9H9orf78 ^@ http://purl.uniprot.org/uniprot/G3RC13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TLS1 family.|||Nucleus http://togogenome.org/gene/9595:PPIL1 ^@ http://purl.uniprot.org/uniprot/G3SAE4 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9595:DTD2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YZI5 ^@ Similarity ^@ Belongs to the DTD family. http://togogenome.org/gene/9595:CXCL12 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y5I3|||http://purl.uniprot.org/uniprot/A0A2I2YFE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9595:NDUFA1 ^@ http://purl.uniprot.org/uniprot/Q8SPF0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA1 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:ATOH7 ^@ http://purl.uniprot.org/uniprot/G3RK03 ^@ Subcellular Location Annotation ^@ Nucleus|||Perikaryon|||axon http://togogenome.org/gene/9595:C1S ^@ http://purl.uniprot.org/uniprot/G3QGI0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:DPM2 ^@ http://purl.uniprot.org/uniprot/G3RUH3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPM2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum membrane|||Membrane|||Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. http://togogenome.org/gene/9595:LOC101140082 ^@ http://purl.uniprot.org/uniprot/G3QMN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ADAMTS12 ^@ http://purl.uniprot.org/uniprot/G3R2M2 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9595:CBL ^@ http://purl.uniprot.org/uniprot/G3RNI2 ^@ Domain|||Function ^@ E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.|||The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain. http://togogenome.org/gene/9595:MRPS14 ^@ http://purl.uniprot.org/uniprot/G3QT30 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS14 family. http://togogenome.org/gene/9595:EFHC2 ^@ http://purl.uniprot.org/uniprot/G3RA83 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9595:SLC4A4 ^@ http://purl.uniprot.org/uniprot/G3R1F8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9595:ARL5A ^@ http://purl.uniprot.org/uniprot/G3RTY5 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9595:JARID2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y3Q1|||http://purl.uniprot.org/uniprot/G3QS10 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:CACNB4 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z399|||http://purl.uniprot.org/uniprot/A0A2I2Z7M7|||http://purl.uniprot.org/uniprot/A0A2I2Z8N3|||http://purl.uniprot.org/uniprot/A0A2I2ZP35 ^@ Similarity ^@ Belongs to the calcium channel beta subunit family. http://togogenome.org/gene/9595:LOC101149752 ^@ http://purl.uniprot.org/uniprot/G3RXW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PET117 family.|||Mitochondrion http://togogenome.org/gene/9595:PSMD7 ^@ http://purl.uniprot.org/uniprot/G3R2T5 ^@ Similarity ^@ Belongs to the peptidase M67A family. http://togogenome.org/gene/9595:DEFB116 ^@ http://purl.uniprot.org/uniprot/G3QTR7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9595:SYNE3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YP70 ^@ Similarity ^@ Belongs to the nesprin family. http://togogenome.org/gene/9595:USP11 ^@ http://purl.uniprot.org/uniprot/A0A2I2YAR1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Cytoplasm|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Nucleus http://togogenome.org/gene/9595:PIGP ^@ http://purl.uniprot.org/uniprot/G3R440 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGP family.|||Membrane|||Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. http://togogenome.org/gene/9595:SLC17A1 ^@ http://purl.uniprot.org/uniprot/G3QW67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.|||Membrane http://togogenome.org/gene/9595:TFEC ^@ http://purl.uniprot.org/uniprot/A0A2I2Z2L0|||http://purl.uniprot.org/uniprot/G3R351 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/9595:MRPL36 ^@ http://purl.uniprot.org/uniprot/G3RLA0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/9595:INTS13 ^@ http://purl.uniprot.org/uniprot/G3R846 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the asunder family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:MGAT1 ^@ http://purl.uniprot.org/uniprot/G3R2D6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 13 family.|||Golgi apparatus membrane|||Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.|||Membrane|||The cofactor is mostly bound to the substrate. http://togogenome.org/gene/9595:CAPN1 ^@ http://purl.uniprot.org/uniprot/G3QXN8 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9595:LOC101143204 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZQT0 ^@ Similarity ^@ Belongs to the MORF4 family-associated protein family. http://togogenome.org/gene/9595:DHRS7B ^@ http://purl.uniprot.org/uniprot/G3QZH0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9595:LOC101140821 ^@ http://purl.uniprot.org/uniprot/G3QCW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:SLC4A5 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1F6 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9595:RNFT1 ^@ http://purl.uniprot.org/uniprot/G3R6G0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:KCNJ15 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z4P9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9595:WNT11 ^@ http://purl.uniprot.org/uniprot/G3RGC0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9595:DZIP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZXW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DZIP C2H2-type zinc-finger protein family.|||cilium basal body http://togogenome.org/gene/9595:PRND ^@ http://purl.uniprot.org/uniprot/A0A2I2YNH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prion family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:DAP3 ^@ http://purl.uniprot.org/uniprot/G3QXB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS29 family.|||Mitochondrion http://togogenome.org/gene/9595:OSM ^@ http://purl.uniprot.org/uniprot/G3QW65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LIF/OSM family.|||Secreted http://togogenome.org/gene/9595:ERGIC1 ^@ http://purl.uniprot.org/uniprot/G3QZF6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/9595:LARS1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YZA8 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9595:SLBP ^@ http://purl.uniprot.org/uniprot/G3QKY0 ^@ Similarity ^@ Belongs to the SLBP family. http://togogenome.org/gene/9595:GMPPB ^@ http://purl.uniprot.org/uniprot/A0A2I2YRI1|||http://purl.uniprot.org/uniprot/G3R4Z4 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/9595:ITIH2 ^@ http://purl.uniprot.org/uniprot/G3R8I3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/9595:AFF1 ^@ http://purl.uniprot.org/uniprot/G3RNV3 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/9595:REM2 ^@ http://purl.uniprot.org/uniprot/G3RI30 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9595:AHCYL2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YIC1|||http://purl.uniprot.org/uniprot/G3RMJ5 ^@ Similarity ^@ Belongs to the adenosylhomocysteinase family. http://togogenome.org/gene/9595:TES ^@ http://purl.uniprot.org/uniprot/A0A2I2ZMW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prickle / espinas / testin family.|||Cytoplasm|||focal adhesion http://togogenome.org/gene/9595:SLC11A1 ^@ http://purl.uniprot.org/uniprot/G3RC10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NRAMP family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/9595:PRDM1 ^@ http://purl.uniprot.org/uniprot/G3QHR5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily.|||Cytoplasm|||Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.|||Nucleus|||Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions. http://togogenome.org/gene/9595:KIF12 ^@ http://purl.uniprot.org/uniprot/G3RE82 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9595:SLC35D1 ^@ http://purl.uniprot.org/uniprot/G3R0Z0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:SPEM1 ^@ http://purl.uniprot.org/uniprot/G3R818 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:MTRFR ^@ http://purl.uniprot.org/uniprot/G3RAQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Mitochondrion http://togogenome.org/gene/9595:FAM219B ^@ http://purl.uniprot.org/uniprot/G3RFM9 ^@ Similarity ^@ Belongs to the FAM219 family. http://togogenome.org/gene/9595:AK6 ^@ http://purl.uniprot.org/uniprot/G3RHN9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.|||Cajal body|||Monomer and homodimer. Interacts with COIL (via C-terminus).|||nucleoplasm http://togogenome.org/gene/9595:TOP1MT ^@ http://purl.uniprot.org/uniprot/G3R1M7 ^@ Function|||Similarity ^@ Belongs to the type IB topoisomerase family.|||Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/9595:SPOUT1 ^@ http://purl.uniprot.org/uniprot/G3REA5 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. http://togogenome.org/gene/9595:LOC101134056 ^@ http://purl.uniprot.org/uniprot/G3RRG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:PIR ^@ http://purl.uniprot.org/uniprot/G3QJY8 ^@ Similarity ^@ Belongs to the pirin family. http://togogenome.org/gene/9595:PROP1 ^@ http://purl.uniprot.org/uniprot/G3SCA7 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes. http://togogenome.org/gene/9595:PPP2R5C ^@ http://purl.uniprot.org/uniprot/A0A2I2YTW3|||http://purl.uniprot.org/uniprot/G3RQ66 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9595:MAN1B1 ^@ http://purl.uniprot.org/uniprot/G3SHK3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9595:ENY2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y869 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ENY2 family.|||Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.|||Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.|||nucleoplasm http://togogenome.org/gene/9595:EZR ^@ http://purl.uniprot.org/uniprot/G3RBW2 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/9595:NEMF ^@ http://purl.uniprot.org/uniprot/G3R0Z6 ^@ Similarity ^@ Belongs to the NEMF family. http://togogenome.org/gene/9595:LOC101137195 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y2B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 20 family.|||Lysosome http://togogenome.org/gene/9595:GBGT1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZTB8|||http://purl.uniprot.org/uniprot/G3QLN1 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 6 family.|||Binds 1 Mn(2+) ion per subunit.|||Membrane http://togogenome.org/gene/9595:RASSF5 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZRM3 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9595:JRKL ^@ http://purl.uniprot.org/uniprot/G3QDN0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SFR1 ^@ http://purl.uniprot.org/uniprot/G3S8T0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SFR1/MEI5 family.|||Nucleus http://togogenome.org/gene/9595:YTHDF2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZSY7 ^@ Function|||Similarity ^@ Belongs to the YTHDF family.|||Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. http://togogenome.org/gene/9595:B3GNT5 ^@ http://purl.uniprot.org/uniprot/A0A2I2YLJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:GIPC3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YSU6 ^@ Similarity ^@ Belongs to the GIPC family. http://togogenome.org/gene/9595:POLB ^@ http://purl.uniprot.org/uniprot/G3SIQ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||Cytoplasm|||DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.|||Nucleus http://togogenome.org/gene/9595:FAM13B ^@ http://purl.uniprot.org/uniprot/A0A2I2ZTU0|||http://purl.uniprot.org/uniprot/G3RWK1 ^@ Similarity ^@ Belongs to the FAM13 family. http://togogenome.org/gene/9595:HPRT1 ^@ http://purl.uniprot.org/uniprot/G3SIK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/9595:SRM ^@ http://purl.uniprot.org/uniprot/G3RPZ5 ^@ Similarity ^@ Belongs to the spermidine/spermine synthase family. http://togogenome.org/gene/9595:NRP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YSW1|||http://purl.uniprot.org/uniprot/G3R279 ^@ Caution|||Similarity ^@ Belongs to the neuropilin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:SARS2 ^@ http://purl.uniprot.org/uniprot/G3S4S3 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily. http://togogenome.org/gene/9595:NUP88 ^@ http://purl.uniprot.org/uniprot/A0A2I2YF80 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/9595:PPP1R10 ^@ http://purl.uniprot.org/uniprot/G3R6Q9 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers. http://togogenome.org/gene/9595:TAFA4 ^@ http://purl.uniprot.org/uniprot/G3R5L3 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/9595:MAT2A ^@ http://purl.uniprot.org/uniprot/G3QQH2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/9595:MTFR1L ^@ http://purl.uniprot.org/uniprot/G3SBB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission. http://togogenome.org/gene/9595:TRMT2A ^@ http://purl.uniprot.org/uniprot/G3QES2 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:LDOC1 ^@ http://purl.uniprot.org/uniprot/Q6SEH5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LDOC1 family.|||Interacts with NOD2.|||May have an important role in the development and/or progression of some cancers.|||Nucleus http://togogenome.org/gene/9595:ALDH8A1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZAD8|||http://purl.uniprot.org/uniprot/G3RI26 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9595:BTN2A1 ^@ http://purl.uniprot.org/uniprot/G3RF61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Membrane http://togogenome.org/gene/9595:DNASE1L3 ^@ http://purl.uniprot.org/uniprot/G3R3K2 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/9595:ACOX1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z314|||http://purl.uniprot.org/uniprot/G3QPK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/9595:DKKL1 ^@ http://purl.uniprot.org/uniprot/G3RJT6 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9595:MEPCE ^@ http://purl.uniprot.org/uniprot/G3QRK4 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/9595:GLO1 ^@ http://purl.uniprot.org/uniprot/G3RX74 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the glyoxalase I family.|||Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.|||Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. http://togogenome.org/gene/9595:GPR31 ^@ http://purl.uniprot.org/uniprot/G3QWQ4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:CDKN2AIPNL ^@ http://purl.uniprot.org/uniprot/G3RZA2 ^@ Similarity ^@ Belongs to the CARF family. http://togogenome.org/gene/9595:KCNT1 ^@ http://purl.uniprot.org/uniprot/G3QR87 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:CORO6 ^@ http://purl.uniprot.org/uniprot/G3QE81 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/9595:TCTN1 ^@ http://purl.uniprot.org/uniprot/G3QN48 ^@ Similarity|||Subunit ^@ Belongs to the tectonic family.|||Part of the tectonic-like complex (also named B9 complex). http://togogenome.org/gene/9595:TADA3 ^@ http://purl.uniprot.org/uniprot/G3REE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NGG1 family.|||Nucleus http://togogenome.org/gene/9595:PLOD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z5C6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9595:EXO5 ^@ http://purl.uniprot.org/uniprot/G3S9X2 ^@ Similarity ^@ Belongs to the EXO5 family. http://togogenome.org/gene/9595:GJA9 ^@ http://purl.uniprot.org/uniprot/G3QSP4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9595:MGAT5 ^@ http://purl.uniprot.org/uniprot/G3QKL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 18 family.|||Golgi apparatus membrane|||Membrane|||Secreted http://togogenome.org/gene/9595:INKA2 ^@ http://purl.uniprot.org/uniprot/G3SJG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INKA family.|||Nucleus http://togogenome.org/gene/9595:GGT5 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZXN2|||http://purl.uniprot.org/uniprot/G3QRZ3 ^@ Similarity ^@ Belongs to the gamma-glutamyltransferase family. http://togogenome.org/gene/9595:TMEM176B ^@ http://purl.uniprot.org/uniprot/G3RK31 ^@ Similarity ^@ Belongs to the TMEM176 family. http://togogenome.org/gene/9595:SLC43A3 ^@ http://purl.uniprot.org/uniprot/G3R2Y0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:AVPR2 ^@ http://purl.uniprot.org/uniprot/G3SIA8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.|||Membrane http://togogenome.org/gene/9595:LRP12 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZJH8|||http://purl.uniprot.org/uniprot/G3R8C7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:NOVA1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZVW4|||http://purl.uniprot.org/uniprot/G3RRA1 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with PTBP2; the interaction is direct.|||Nucleus http://togogenome.org/gene/9595:LOC101127636 ^@ http://purl.uniprot.org/uniprot/G3R782 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9595:S100B ^@ http://purl.uniprot.org/uniprot/G3S1E6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the S-100 family.|||Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/9595:LIPH ^@ http://purl.uniprot.org/uniprot/G3S122 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9595:ADH6 ^@ http://purl.uniprot.org/uniprot/G3QFJ0 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/9595:NUPR1 ^@ http://purl.uniprot.org/uniprot/G3QD60 ^@ Similarity ^@ Belongs to the NUPR family. http://togogenome.org/gene/9595:ZKSCAN1 ^@ http://purl.uniprot.org/uniprot/G3QQX3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:KCNH5 ^@ http://purl.uniprot.org/uniprot/G3SKT9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:GNPTAB ^@ http://purl.uniprot.org/uniprot/G3R2W9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the stealth family.|||Membrane http://togogenome.org/gene/9595:YIPF4 ^@ http://purl.uniprot.org/uniprot/G3R901 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:VPS13A ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1I4|||http://purl.uniprot.org/uniprot/A0A2I2ZIU4|||http://purl.uniprot.org/uniprot/A0A2I2ZY86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS13 family.|||Lipid droplet http://togogenome.org/gene/9595:SPCS1 ^@ http://purl.uniprot.org/uniprot/G3RSY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:FAIM2 ^@ http://purl.uniprot.org/uniprot/G3SA66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9595:PSMB9 ^@ http://purl.uniprot.org/uniprot/G3R5V5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:KCNJ5 ^@ http://purl.uniprot.org/uniprot/G3S2K8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.|||Membrane http://togogenome.org/gene/9595:NSUN5 ^@ http://purl.uniprot.org/uniprot/G3R7U5 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/9595:LOC101132751 ^@ http://purl.uniprot.org/uniprot/G3RW89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MUSTANG family.|||Nucleus http://togogenome.org/gene/9595:ELOVL4 ^@ http://purl.uniprot.org/uniprot/G3R1R5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ELO family. ELOVL4 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.|||Endoplasmic reticulum membrane|||Membrane|||Oligomer.|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9595:PRM1 ^@ http://purl.uniprot.org/uniprot/P35303 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the protamine P1 family.|||Chromosome|||Cross-linked by interchain disulfide bonds around the DNA-helix.|||Nucleus|||Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.|||Testis. http://togogenome.org/gene/9595:CCNO ^@ http://purl.uniprot.org/uniprot/G3R198 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9595:RPIA ^@ http://purl.uniprot.org/uniprot/G3SGC2 ^@ Similarity ^@ Belongs to the ribose 5-phosphate isomerase family. http://togogenome.org/gene/9595:MOS ^@ http://purl.uniprot.org/uniprot/G3SKC1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:ANK3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z6M3|||http://purl.uniprot.org/uniprot/G3QMX5 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/9595:B4GALT2 ^@ http://purl.uniprot.org/uniprot/G3QM53 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9595:RPS29 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z627 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Component of the 40S small ribosomal subunit. http://togogenome.org/gene/9595:PDIA2 ^@ http://purl.uniprot.org/uniprot/G3R2R4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9595:GTF2B ^@ http://purl.uniprot.org/uniprot/G3RWT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIB family.|||Nucleus http://togogenome.org/gene/9595:GABRA2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YVQ9|||http://purl.uniprot.org/uniprot/G3QVC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||dendrite http://togogenome.org/gene/9595:OSBPL8 ^@ http://purl.uniprot.org/uniprot/G3S7W9 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9595:IDI2 ^@ http://purl.uniprot.org/uniprot/G3RC34 ^@ Function|||Similarity ^@ Belongs to the IPP isomerase type 1 family.|||Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). http://togogenome.org/gene/9595:STPG1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z355|||http://purl.uniprot.org/uniprot/G3QHE1|||http://purl.uniprot.org/uniprot/G3SCP8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9595:ELOVL3 ^@ http://purl.uniprot.org/uniprot/G3S163 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL3 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||N-Glycosylated.|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9595:BTC ^@ http://purl.uniprot.org/uniprot/G3RD79 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:BMPR1A ^@ http://purl.uniprot.org/uniprot/G3QMC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9595:GALNT15 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z158|||http://purl.uniprot.org/uniprot/G3R1J7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:PRPF38A ^@ http://purl.uniprot.org/uniprot/G3QMW7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PRP38 family.|||Component of the spliceosome B complex.|||Involved in pre-mRNA splicing as a component of the spliceosome.|||Nucleus http://togogenome.org/gene/9595:CDKN3 ^@ http://purl.uniprot.org/uniprot/G3QSG9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family.|||May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues.|||perinuclear region http://togogenome.org/gene/9595:STK4 ^@ http://purl.uniprot.org/uniprot/G3RCG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Nucleus http://togogenome.org/gene/9595:SNX6 ^@ http://purl.uniprot.org/uniprot/A0A2I2YBM0 ^@ Function|||Similarity ^@ Belongs to the sorting nexin family.|||Involved in several stages of intracellular trafficking. http://togogenome.org/gene/9595:PRKAR1B ^@ http://purl.uniprot.org/uniprot/G3R8D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:TUBB8 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZJA6|||http://purl.uniprot.org/uniprot/G3S4L8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9595:ABI3 ^@ http://purl.uniprot.org/uniprot/G3QHT8 ^@ Similarity ^@ Belongs to the ABI family. http://togogenome.org/gene/9595:AHSA1 ^@ http://purl.uniprot.org/uniprot/G3QXU4 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/9595:LOC101143714 ^@ http://purl.uniprot.org/uniprot/G3REF2 ^@ Similarity ^@ Belongs to the Schlafen family. Subgroup III subfamily. http://togogenome.org/gene/9595:KRT79 ^@ http://purl.uniprot.org/uniprot/G3QMQ3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:DMRTC2 ^@ http://purl.uniprot.org/uniprot/G3S9N9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/9595:SERPINI2 ^@ http://purl.uniprot.org/uniprot/G3R4R7 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9595:TTC39A ^@ http://purl.uniprot.org/uniprot/A0A2I2ZCZ1|||http://purl.uniprot.org/uniprot/G3RB17 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/9595:ENOPH1 ^@ http://purl.uniprot.org/uniprot/G3QMC0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.|||Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Monomer.|||Nucleus http://togogenome.org/gene/9595:GOLT1B ^@ http://purl.uniprot.org/uniprot/A0A2I2ZSS8|||http://purl.uniprot.org/uniprot/G3SDX7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||May be involved in fusion of ER-derived transport vesicles with the Golgi complex.|||Membrane http://togogenome.org/gene/9595:SOSTDC1 ^@ http://purl.uniprot.org/uniprot/G3R2X4 ^@ Caution|||Similarity ^@ Belongs to the sclerostin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:CAPRIN2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z5V8|||http://purl.uniprot.org/uniprot/G3QTM9 ^@ Similarity ^@ Belongs to the caprin family. http://togogenome.org/gene/9595:NHEJ1 ^@ http://purl.uniprot.org/uniprot/G3R5H3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XRCC4-XLF family. XLF subfamily.|||Nucleus http://togogenome.org/gene/9595:PCLAF ^@ http://purl.uniprot.org/uniprot/A0A2I2Z3H6|||http://purl.uniprot.org/uniprot/G3QM99 ^@ Subcellular Location Annotation ^@ Nucleus|||perinuclear region http://togogenome.org/gene/9595:LOC101150033 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZPE1 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9595:ATP10D ^@ http://purl.uniprot.org/uniprot/G3SKB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9595:COPS5 ^@ http://purl.uniprot.org/uniprot/G3RJK0|||http://purl.uniprot.org/uniprot/G3SFM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M67A family. CSN5 subfamily.|||synaptic vesicle http://togogenome.org/gene/9595:EPHA6 ^@ http://purl.uniprot.org/uniprot/G3SKT8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:EYA1 ^@ http://purl.uniprot.org/uniprot/G3QL19 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/9595:CETN1 ^@ http://purl.uniprot.org/uniprot/G3QG53 ^@ Similarity ^@ Belongs to the centrin family. http://togogenome.org/gene/9595:VHL ^@ http://purl.uniprot.org/uniprot/A0A2I2Y385|||http://purl.uniprot.org/uniprot/G3R4I8 ^@ Similarity ^@ Belongs to the VHL family. http://togogenome.org/gene/9595:FYTTD1 ^@ http://purl.uniprot.org/uniprot/G3R7N6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UIF family.|||Nucleus speckle|||nucleoplasm http://togogenome.org/gene/9595:PURB ^@ http://purl.uniprot.org/uniprot/G3SF88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PUR DNA-binding protein family.|||Nucleus http://togogenome.org/gene/9595:PTPRB ^@ http://purl.uniprot.org/uniprot/A0A2I2Y937|||http://purl.uniprot.org/uniprot/G3QTY6 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily. http://togogenome.org/gene/9595:CPSF6 ^@ http://purl.uniprot.org/uniprot/A0A2I2YN73|||http://purl.uniprot.org/uniprot/G3SJR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM CPSF6/7 family.|||Nucleus http://togogenome.org/gene/9595:OXSM ^@ http://purl.uniprot.org/uniprot/A0A2I2ZME2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.|||Mitochondrion http://togogenome.org/gene/9595:LAMB4 ^@ http://purl.uniprot.org/uniprot/A0A2I2YHY8|||http://purl.uniprot.org/uniprot/G3RKT7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/9595:CHAF1B ^@ http://purl.uniprot.org/uniprot/G3RI54 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:GFRA3 ^@ http://purl.uniprot.org/uniprot/G3RMP9 ^@ Similarity ^@ Belongs to the GDNFR family. http://togogenome.org/gene/9595:SLC25A32 ^@ http://purl.uniprot.org/uniprot/G3SFY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9595:MAP3K13 ^@ http://purl.uniprot.org/uniprot/G3RB11 ^@ Function|||Similarity ^@ Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7.|||Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/9595:LOC101133585 ^@ http://purl.uniprot.org/uniprot/G3S402 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:NAP1L3 ^@ http://purl.uniprot.org/uniprot/G3RLD6 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9595:ASPH ^@ http://purl.uniprot.org/uniprot/A0A2I2YKA1|||http://purl.uniprot.org/uniprot/A0A2I2ZY46|||http://purl.uniprot.org/uniprot/G3R0I3|||http://purl.uniprot.org/uniprot/G3S8Z3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartyl/asparaginyl beta-hydroxylase family.|||Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/9595:TMEM86A ^@ http://purl.uniprot.org/uniprot/G3QW95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM86 family.|||Membrane http://togogenome.org/gene/9595:NTMT2 ^@ http://purl.uniprot.org/uniprot/G3R7V8 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. NTM1 family. http://togogenome.org/gene/9595:SLC52A2 ^@ http://purl.uniprot.org/uniprot/G3SIW6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the riboflavin transporter family.|||Cell membrane|||Membrane|||Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. http://togogenome.org/gene/9595:EMC8 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZV79|||http://purl.uniprot.org/uniprot/G3RLC5 ^@ Similarity ^@ Belongs to the EMC8/EMC9 family. http://togogenome.org/gene/9595:DSC2 ^@ http://purl.uniprot.org/uniprot/G3QTI1 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.|||Membrane|||desmosome http://togogenome.org/gene/9595:TCIRG1 ^@ http://purl.uniprot.org/uniprot/G3QQP0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/9595:CAND1 ^@ http://purl.uniprot.org/uniprot/G3QF05 ^@ Similarity ^@ Belongs to the CAND family. http://togogenome.org/gene/9595:HNF4G ^@ http://purl.uniprot.org/uniprot/G3QZI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9595:TMEM59L ^@ http://purl.uniprot.org/uniprot/G3RSB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM59 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:NRM ^@ http://purl.uniprot.org/uniprot/G3QEL9|||http://purl.uniprot.org/uniprot/G3SBX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nurim family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/9595:HOXC12 ^@ http://purl.uniprot.org/uniprot/G3RNH1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:NDUFB6 ^@ http://purl.uniprot.org/uniprot/Q0MQE0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB6 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:MBTPS2 ^@ http://purl.uniprot.org/uniprot/G3R8Q6 ^@ Similarity ^@ Belongs to the peptidase M50A family. http://togogenome.org/gene/9595:DDC ^@ http://purl.uniprot.org/uniprot/A0A2I2YGG3|||http://purl.uniprot.org/uniprot/G3QTY2 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9595:PEX16 ^@ http://purl.uniprot.org/uniprot/G3QIP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-16 family.|||Peroxisome membrane http://togogenome.org/gene/9595:TDRD5 ^@ http://purl.uniprot.org/uniprot/G3R6R4|||http://purl.uniprot.org/uniprot/G3S9Q2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TDRD5 family.|||Cytoplasm|||Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly. http://togogenome.org/gene/9595:ADAMTS4 ^@ http://purl.uniprot.org/uniprot/G3QXK7 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9595:FGF6 ^@ http://purl.uniprot.org/uniprot/G3QX89 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9595:GDI1 ^@ http://purl.uniprot.org/uniprot/G3RCC0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP. http://togogenome.org/gene/9595:CD1A ^@ http://purl.uniprot.org/uniprot/G3S7N6 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9595:LOC101142845 ^@ http://purl.uniprot.org/uniprot/G3RPB8 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/9595:CLCN1 ^@ http://purl.uniprot.org/uniprot/G3R6J1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:VAMP5 ^@ http://purl.uniprot.org/uniprot/G3QQI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9595:HDHD2 ^@ http://purl.uniprot.org/uniprot/G3RJW4 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/9595:MTFP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZQC3|||http://purl.uniprot.org/uniprot/G3RAB5 ^@ Similarity ^@ Belongs to the MTFP1 family. http://togogenome.org/gene/9595:USP1 ^@ http://purl.uniprot.org/uniprot/G3S8K7 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9595:KHDRBS2 ^@ http://purl.uniprot.org/uniprot/G3SH19 ^@ Similarity ^@ Belongs to the KHDRBS family. http://togogenome.org/gene/9595:DNAH6 ^@ http://purl.uniprot.org/uniprot/G3QN60 ^@ Similarity ^@ Belongs to the dynein heavy chain family. http://togogenome.org/gene/9595:GOLPH3L ^@ http://purl.uniprot.org/uniprot/G3QEZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLPH3/VPS74 family.|||Golgi stack membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9595:GINS3 ^@ http://purl.uniprot.org/uniprot/G3S1X1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS3/PSF3 family.|||Chromosome|||Component of the GINS complex.|||Nucleus|||The GINS complex plays an essential role in the initiation of DNA replication. http://togogenome.org/gene/9595:PHYHIP ^@ http://purl.uniprot.org/uniprot/G3QWI2 ^@ Similarity ^@ Belongs to the PHYHIP family. http://togogenome.org/gene/9595:GDPD2 ^@ http://purl.uniprot.org/uniprot/G3QH93 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9595:LOC115933122 ^@ http://purl.uniprot.org/uniprot/G3QHY1 ^@ Similarity ^@ Belongs to the PRAME family. http://togogenome.org/gene/9595:ING2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZRE8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9595:KRT5 ^@ http://purl.uniprot.org/uniprot/G3QKU2 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:SFT2D3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YWZ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.|||Membrane http://togogenome.org/gene/9595:MTURN ^@ http://purl.uniprot.org/uniprot/G3QJF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MTURN family.|||Cytoplasm http://togogenome.org/gene/9595:WWOX ^@ http://purl.uniprot.org/uniprot/A0A2I2ZPP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm|||Golgi apparatus|||Lysosome|||Mitochondrion http://togogenome.org/gene/9595:RPL11 ^@ http://purl.uniprot.org/uniprot/G3RWD2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL5 family. http://togogenome.org/gene/9595:TSNAX ^@ http://purl.uniprot.org/uniprot/A0A2I2Y6W7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the translin family.|||Nucleus http://togogenome.org/gene/9595:LPIN3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZWF3 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/9595:IGFL2 ^@ http://purl.uniprot.org/uniprot/G3S3S3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IGFL family.|||Secreted http://togogenome.org/gene/9595:ELAPOR2 ^@ http://purl.uniprot.org/uniprot/G3RFP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELAPOR family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:EVC2 ^@ http://purl.uniprot.org/uniprot/G3SIS4 ^@ Subcellular Location Annotation ^@ Membrane|||cilium basal body|||cilium membrane http://togogenome.org/gene/9595:VPS53 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z785 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS53 family.|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9595:TMEM35A ^@ http://purl.uniprot.org/uniprot/G3S1L3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Membrane http://togogenome.org/gene/9595:OGG1 ^@ http://purl.uniprot.org/uniprot/G3RZB6 ^@ Function|||Similarity ^@ Belongs to the type-1 OGG1 family.|||DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. http://togogenome.org/gene/9595:ZNF446 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZEU4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:HTR2C ^@ http://purl.uniprot.org/uniprot/A0A2I2YCE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:GALNT6 ^@ http://purl.uniprot.org/uniprot/A0A2I2YBP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:BMP4 ^@ http://purl.uniprot.org/uniprot/G3RG26 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9595:LOC101140436 ^@ http://purl.uniprot.org/uniprot/G3QMN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ALX3 ^@ http://purl.uniprot.org/uniprot/G3QN78 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:PLIN1 ^@ http://purl.uniprot.org/uniprot/G3S7F6 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/9595:SLC5A10 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZVK0|||http://purl.uniprot.org/uniprot/G3RAD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:KCNMB1 ^@ http://purl.uniprot.org/uniprot/G3QW55 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KCNMB (TC 8.A.14.1) family.|||Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.|||Membrane|||N-glycosylated.|||Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. http://togogenome.org/gene/9595:CDR2 ^@ http://purl.uniprot.org/uniprot/G3RCU4 ^@ Similarity ^@ Belongs to the CDR2 family. http://togogenome.org/gene/9595:AP2B1 ^@ http://purl.uniprot.org/uniprot/G3S3T5 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/9595:RTCB ^@ http://purl.uniprot.org/uniprot/G3R6Z5 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Catalytic component of the tRNA-splicing ligase complex.|||Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.|||Cytoplasm|||Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP. http://togogenome.org/gene/9595:ITPRIPL1 ^@ http://purl.uniprot.org/uniprot/G3RYQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITPRIP family.|||Membrane http://togogenome.org/gene/9595:USP20 ^@ http://purl.uniprot.org/uniprot/G3QLW2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family. USP20/USP33 subfamily.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||centrosome|||perinuclear region http://togogenome.org/gene/9595:PTCH2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z5R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the patched family.|||Membrane http://togogenome.org/gene/9595:CENPH ^@ http://purl.uniprot.org/uniprot/G3QGP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-H/MCM16 family.|||Nucleus|||kinetochore http://togogenome.org/gene/9595:GLUD2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZHL0 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/9595:SRXN1 ^@ http://purl.uniprot.org/uniprot/G3RKU5 ^@ Similarity ^@ Belongs to the sulfiredoxin family. http://togogenome.org/gene/9595:SIAH1 ^@ http://purl.uniprot.org/uniprot/G3S6X6 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/9595:PARP2 ^@ http://purl.uniprot.org/uniprot/G3RSB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARTD/PARP family.|||Nucleus http://togogenome.org/gene/9595:NDC80 ^@ http://purl.uniprot.org/uniprot/G3QF61 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the NDC80/HEC1 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/9595:LOC101143890 ^@ http://purl.uniprot.org/uniprot/G3QYN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:NDUFAF4 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y870 ^@ Similarity|||Subunit ^@ Belongs to the NDUFAF4 family.|||Binds calmodulin. Interacts with NDUFAF3. http://togogenome.org/gene/9595:ODF2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z072|||http://purl.uniprot.org/uniprot/A0A2I2Z656|||http://purl.uniprot.org/uniprot/A0A2I2Z6R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ODF2 family.|||centrosome http://togogenome.org/gene/9595:LOC101143671 ^@ http://purl.uniprot.org/uniprot/G3S872 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9595:ANXA9 ^@ http://purl.uniprot.org/uniprot/G3QS41 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9595:ETS1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YR13|||http://purl.uniprot.org/uniprot/G3QK39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:TXN ^@ http://purl.uniprot.org/uniprot/G3QVK1 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/9595:CLRN1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YBD1|||http://purl.uniprot.org/uniprot/G3QD42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/9595:PSMG2 ^@ http://purl.uniprot.org/uniprot/G3R3J3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PSMG2 family.|||Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.|||Forms a heterodimer with PSMG1. http://togogenome.org/gene/9595:DAO ^@ http://purl.uniprot.org/uniprot/G3RBQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAMOX/DASOX family.|||Peroxisome http://togogenome.org/gene/9595:NXPH1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z2Q4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/9595:PPP3CA ^@ http://purl.uniprot.org/uniprot/A0A2I2YDT1 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-2B subfamily. http://togogenome.org/gene/9595:HTR6 ^@ http://purl.uniprot.org/uniprot/G3QRC3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:MRPL32 ^@ http://purl.uniprot.org/uniprot/G3S9M7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/9595:PMCH ^@ http://purl.uniprot.org/uniprot/G3R307 ^@ Similarity ^@ Belongs to the melanin-concentrating hormone family. http://togogenome.org/gene/9595:ATP5F1B ^@ http://purl.uniprot.org/uniprot/G3R7H4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/9595:FOXP2 ^@ http://purl.uniprot.org/uniprot/Q8MJ99 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1 (By similarity). Interacts with FOXP1 (By similarity). Interacts with TBR1 (By similarity). Interacts with ZMYM2 (By similarity).|||Nucleus|||The leucine-zipper is required for dimerization and transcriptional repression.|||Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels (By similarity). http://togogenome.org/gene/9595:KDM3A ^@ http://purl.uniprot.org/uniprot/G3QVM5 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the JHDM2 histone demethylase family.|||Binds 1 Fe(2+) ion per subunit.|||Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.|||Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.|||Nucleus|||The JmjC domain and the C6-type zinc-finger are required for the demethylation activity. http://togogenome.org/gene/9595:TMEM218 ^@ http://purl.uniprot.org/uniprot/G3RHQ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM218 family.|||May be involved in ciliary biogenesis or function.|||Membrane|||cilium http://togogenome.org/gene/9595:SMARCAL1 ^@ http://purl.uniprot.org/uniprot/G3RFT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.|||Nucleus http://togogenome.org/gene/9595:NEK9 ^@ http://purl.uniprot.org/uniprot/G3S0W8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. http://togogenome.org/gene/9595:NPPC ^@ http://purl.uniprot.org/uniprot/G3RPI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the natriuretic peptide family.|||Secreted http://togogenome.org/gene/9595:SLITRK5 ^@ http://purl.uniprot.org/uniprot/G3S4W5 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9595:TRIM45 ^@ http://purl.uniprot.org/uniprot/G3SJ16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm http://togogenome.org/gene/9595:LOC101135912 ^@ http://purl.uniprot.org/uniprot/G3QSV5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NADPH--cytochrome P450 reductase family.|||Binds 1 FAD per monomer.|||Binds 1 FMN per monomer.|||Endoplasmic reticulum membrane|||In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||In the N-terminal section; belongs to the flavodoxin family.|||This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. http://togogenome.org/gene/9595:WNT16 ^@ http://purl.uniprot.org/uniprot/A0A2I2YY16|||http://purl.uniprot.org/uniprot/G3RK46 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9595:LOC101135339 ^@ http://purl.uniprot.org/uniprot/G3QT16 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.|||Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. http://togogenome.org/gene/9595:HOMER1 ^@ http://purl.uniprot.org/uniprot/G3QFA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Homer family.|||Cytoplasm|||Postsynaptic density|||Synapse http://togogenome.org/gene/9595:ALKAL1 ^@ http://purl.uniprot.org/uniprot/G3QIX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALKAL family.|||Secreted http://togogenome.org/gene/9595:DNAAF6 ^@ http://purl.uniprot.org/uniprot/G3R369 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/9595:C1R ^@ http://purl.uniprot.org/uniprot/A0A2I2ZAV7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:NCAPD2 ^@ http://purl.uniprot.org/uniprot/G3R282 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CND1 (condensin subunit 1) family.|||Chromosome|||Nucleus|||Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. http://togogenome.org/gene/9595:RRM2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YNS8 ^@ Similarity ^@ Belongs to the ribonucleoside diphosphate reductase small chain family. http://togogenome.org/gene/9595:SKP1 ^@ http://purl.uniprot.org/uniprot/G3RZC5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SKP1 family.|||Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit.|||Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1.|||The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. http://togogenome.org/gene/9595:SEC24D ^@ http://purl.uniprot.org/uniprot/G3QJ79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9595:SURF6 ^@ http://purl.uniprot.org/uniprot/G3RET0 ^@ Similarity ^@ Belongs to the SURF6 family. http://togogenome.org/gene/9595:PINLYP ^@ http://purl.uniprot.org/uniprot/G3QJA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNF-like-inhibitor family.|||Secreted http://togogenome.org/gene/9595:ATG16L1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZR34|||http://purl.uniprot.org/uniprot/G3RJY6|||http://purl.uniprot.org/uniprot/G3SDM6 ^@ Similarity ^@ Belongs to the WD repeat ATG16 family. http://togogenome.org/gene/9595:RPA3 ^@ http://purl.uniprot.org/uniprot/G3SDA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the replication factor A protein 3 family.|||Nucleus http://togogenome.org/gene/9595:IKBKE ^@ http://purl.uniprot.org/uniprot/G3RVG0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:PHB1 ^@ http://purl.uniprot.org/uniprot/G3RYF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Cell membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9595:PSMB4 ^@ http://purl.uniprot.org/uniprot/G3R4T7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1B family.|||Cytoplasm|||Non-catalytic component of the proteasome.|||Nucleus http://togogenome.org/gene/9595:FSCN1 ^@ http://purl.uniprot.org/uniprot/G3RSQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fascin family.|||cytoskeleton http://togogenome.org/gene/9595:LYRM7 ^@ http://purl.uniprot.org/uniprot/G3R8G9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.|||Belongs to the complex I LYR family.|||Interacts with UQCRFS1.|||Mitochondrion matrix http://togogenome.org/gene/9595:CAMK2A ^@ http://purl.uniprot.org/uniprot/A0A2I2Y6I6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9595:ZNF165 ^@ http://purl.uniprot.org/uniprot/G3RE42 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:LOC101145832 ^@ http://purl.uniprot.org/uniprot/G3S373 ^@ Similarity ^@ Belongs to the Gfa family. http://togogenome.org/gene/9595:NOL12 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z691 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRP17 family.|||Interacts with KIAA1191.|||nucleolus http://togogenome.org/gene/9595:SUSD1 ^@ http://purl.uniprot.org/uniprot/G3RA61 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:SLC9A9 ^@ http://purl.uniprot.org/uniprot/G3SKL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/9595:DYNLT2B ^@ http://purl.uniprot.org/uniprot/G3RBT4 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/9595:ELAVL4 ^@ http://purl.uniprot.org/uniprot/A0A2I2YP86|||http://purl.uniprot.org/uniprot/A0A2I2Z663|||http://purl.uniprot.org/uniprot/G3QED2|||http://purl.uniprot.org/uniprot/G3SHV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM elav family.|||Cytoplasm|||Perikaryon|||axon|||dendrite|||growth cone http://togogenome.org/gene/9595:DKK4 ^@ http://purl.uniprot.org/uniprot/G3RIA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/9595:ADRB2 ^@ http://purl.uniprot.org/uniprot/G3QRR6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.|||Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.|||Cell membrane|||Early endosome|||Golgi apparatus|||Membrane http://togogenome.org/gene/9595:TMTC3 ^@ http://purl.uniprot.org/uniprot/G3RAC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/9595:RNF43 ^@ http://purl.uniprot.org/uniprot/G3QWC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZNRF3 family.|||Cell membrane http://togogenome.org/gene/9595:PSMD2 ^@ http://purl.uniprot.org/uniprot/G3S503 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S2 family.|||Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. http://togogenome.org/gene/9595:DIPK2A ^@ http://purl.uniprot.org/uniprot/G3RGM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Secreted http://togogenome.org/gene/9595:LOC101148590 ^@ http://purl.uniprot.org/uniprot/G3SAN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:SHCBP1 ^@ http://purl.uniprot.org/uniprot/G3R5S3 ^@ Subcellular Location Annotation ^@ spindle http://togogenome.org/gene/9595:ZDHHC2 ^@ http://purl.uniprot.org/uniprot/G3RL61 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9595:CCL3 ^@ http://purl.uniprot.org/uniprot/G3RWY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9595:ARPC1B ^@ http://purl.uniprot.org/uniprot/G3RBK8 ^@ Function|||Similarity ^@ Belongs to the WD repeat ARPC1 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. http://togogenome.org/gene/9595:TRAF4 ^@ http://purl.uniprot.org/uniprot/G3RKR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/9595:SF3B6 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y6J6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:VAC14 ^@ http://purl.uniprot.org/uniprot/G3RBC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VAC14 family.|||Endosome membrane|||Microsome membrane http://togogenome.org/gene/9595:SSU72 ^@ http://purl.uniprot.org/uniprot/G3QP49 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SSU72 phosphatase family.|||Nucleus|||Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. http://togogenome.org/gene/9595:ZACN ^@ http://purl.uniprot.org/uniprot/G3R0D3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:MOXD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZJF9 ^@ Similarity ^@ Belongs to the copper type II ascorbate-dependent monooxygenase family. http://togogenome.org/gene/9595:CAMK2N2 ^@ http://purl.uniprot.org/uniprot/G3QHS2 ^@ Similarity ^@ Belongs to the CAMK2N family. http://togogenome.org/gene/9595:TCP11 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZT34 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/9595:IMMT ^@ http://purl.uniprot.org/uniprot/A0A2I2Y8X3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic60 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:MAP3K5 ^@ http://purl.uniprot.org/uniprot/G3S3K1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/9595:GIMAP1 ^@ http://purl.uniprot.org/uniprot/G3SIP9 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9595:CPN1 ^@ http://purl.uniprot.org/uniprot/G3S6R8 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9595:TFPI ^@ http://purl.uniprot.org/uniprot/A0A2I2ZNY5 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9595:CNN3 ^@ http://purl.uniprot.org/uniprot/G3RDC6|||http://purl.uniprot.org/uniprot/G3S2H0 ^@ Function|||Similarity ^@ Belongs to the calponin family.|||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. http://togogenome.org/gene/9595:GAR1 ^@ http://purl.uniprot.org/uniprot/G3R011 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GAR1 family.|||Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).|||Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.|||nucleolus http://togogenome.org/gene/9595:NANOG ^@ http://purl.uniprot.org/uniprot/G3S4N9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:IL1B ^@ http://purl.uniprot.org/uniprot/G3QU53 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-1 family.|||IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.|||Lysosome|||Monomer. Interacts with MEFV.|||Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.|||Secreted|||cytosol|||extracellular exosome http://togogenome.org/gene/9595:FPR2 ^@ http://purl.uniprot.org/uniprot/G3QSB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:MTMR11 ^@ http://purl.uniprot.org/uniprot/G3QQ15 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9595:UBA7 ^@ http://purl.uniprot.org/uniprot/G3SJ75 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/9595:RAN ^@ http://purl.uniprot.org/uniprot/A0A2I2ZH95 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ran family.|||GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.|||Nucleus http://togogenome.org/gene/9595:USP9X ^@ http://purl.uniprot.org/uniprot/G3SIQ8 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/9595:UBE2E3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y330 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9595:KCNN4 ^@ http://purl.uniprot.org/uniprot/G3QRW2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:PRKCB ^@ http://purl.uniprot.org/uniprot/G3R5W0|||http://purl.uniprot.org/uniprot/G3SFA7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.|||Cytoplasm|||Membrane|||Nucleus http://togogenome.org/gene/9595:HOXD3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z5T2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9595:PIP4P2 ^@ http://purl.uniprot.org/uniprot/G3RLV6 ^@ Function|||Subcellular Location Annotation ^@ Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane|||phagosome membrane http://togogenome.org/gene/9595:TOM1L2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z824|||http://purl.uniprot.org/uniprot/G3QDZ4 ^@ Similarity ^@ Belongs to the TOM1 family. http://togogenome.org/gene/9595:TMEM41A ^@ http://purl.uniprot.org/uniprot/A0A2I2YZ29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM41 family.|||Membrane http://togogenome.org/gene/9595:MDGA1 ^@ http://purl.uniprot.org/uniprot/G3RYJ7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:LRP6 ^@ http://purl.uniprot.org/uniprot/G3QI56 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LDLR family.|||Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes.|||Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:DDX55 ^@ http://purl.uniprot.org/uniprot/G3SB92 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9595:LOC101144978 ^@ http://purl.uniprot.org/uniprot/G3RE85 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9595:NETO2 ^@ http://purl.uniprot.org/uniprot/G3SFF0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:OAS2 ^@ http://purl.uniprot.org/uniprot/G3QYM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-5A synthase family.|||Cytoplasm http://togogenome.org/gene/9595:OASL ^@ http://purl.uniprot.org/uniprot/G3R8V7 ^@ Similarity ^@ Belongs to the 2-5A synthase family. http://togogenome.org/gene/9595:WSCD1 ^@ http://purl.uniprot.org/uniprot/G3QNF2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WSCD family.|||Golgi apparatus membrane|||Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans. http://togogenome.org/gene/9595:RPL13A ^@ http://purl.uniprot.org/uniprot/G3QKB2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/9595:TIMM10B ^@ http://purl.uniprot.org/uniprot/G3S1T0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9595:EIF4H ^@ http://purl.uniprot.org/uniprot/G3QRD1 ^@ Function|||Subcellular Location Annotation ^@ Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.|||perinuclear region http://togogenome.org/gene/9595:NDFIP1 ^@ http://purl.uniprot.org/uniprot/G3QQB6 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Membrane http://togogenome.org/gene/9595:DIPK2B ^@ http://purl.uniprot.org/uniprot/G3RKI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Secreted http://togogenome.org/gene/9595:ASPN ^@ http://purl.uniprot.org/uniprot/G3SJH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||extracellular matrix http://togogenome.org/gene/9595:HOXD12 ^@ http://purl.uniprot.org/uniprot/G3QG72 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:STARD13 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZC42 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:ST6GALNAC5 ^@ http://purl.uniprot.org/uniprot/G3QRS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9595:SGCZ ^@ http://purl.uniprot.org/uniprot/G3QD31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/9595:NEK7 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZMH9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:GRWD1 ^@ http://purl.uniprot.org/uniprot/G3RC94 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:CEMIP ^@ http://purl.uniprot.org/uniprot/G3QPF6 ^@ Similarity ^@ Belongs to the CEMIP family. http://togogenome.org/gene/9595:GCLM ^@ http://purl.uniprot.org/uniprot/G3RJX6 ^@ Similarity|||Subunit ^@ Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.|||Heterodimer of a catalytic heavy chain and a regulatory light chain. http://togogenome.org/gene/9595:DIS3L ^@ http://purl.uniprot.org/uniprot/G3QGR8 ^@ Similarity ^@ Belongs to the RNR ribonuclease family. http://togogenome.org/gene/9595:AMIGO3 ^@ http://purl.uniprot.org/uniprot/G3R4Y9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. AMIGO family.|||Membrane http://togogenome.org/gene/9595:CLDN16 ^@ http://purl.uniprot.org/uniprot/G3SJW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9595:PHGDH ^@ http://purl.uniprot.org/uniprot/G3R451 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/9595:SERPINB4 ^@ http://purl.uniprot.org/uniprot/G3SDA7 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9595:VARS1 ^@ http://purl.uniprot.org/uniprot/G3R6X1 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9595:THG1L ^@ http://purl.uniprot.org/uniprot/G3R000 ^@ Cofactor|||Function|||Similarity ^@ Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.|||Belongs to the tRNA(His) guanylyltransferase family.|||Binds 2 magnesium ions per subunit. http://togogenome.org/gene/9595:FANCM ^@ http://purl.uniprot.org/uniprot/G3QZQ3 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. http://togogenome.org/gene/9595:AKR1E2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YH99|||http://purl.uniprot.org/uniprot/G3R651 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9595:TAC3 ^@ http://purl.uniprot.org/uniprot/G3RGH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tachykinin family.|||Secreted http://togogenome.org/gene/9595:ALAS2 ^@ http://purl.uniprot.org/uniprot/G3QI29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:BCL2L10 ^@ http://purl.uniprot.org/uniprot/G3QLU6 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9595:CCKAR ^@ http://purl.uniprot.org/uniprot/G3RGQ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9595:LOC101147473 ^@ http://purl.uniprot.org/uniprot/A0A2I2YW10 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9595:TFDP3 ^@ http://purl.uniprot.org/uniprot/G3RYF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9595:LPAR1 ^@ http://purl.uniprot.org/uniprot/G3S1C7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cell surface|||Endosome|||Membrane http://togogenome.org/gene/9595:TREH ^@ http://purl.uniprot.org/uniprot/G3RH50 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 37 family. http://togogenome.org/gene/9595:ZRANB1 ^@ http://purl.uniprot.org/uniprot/G3RL11 ^@ Similarity ^@ Belongs to the peptidase C64 family. http://togogenome.org/gene/9595:LYSET ^@ http://purl.uniprot.org/uniprot/G3S4R4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LYSET family.|||Membrane http://togogenome.org/gene/9595:OSBPL11 ^@ http://purl.uniprot.org/uniprot/G3QX33 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9595:RAB27A ^@ http://purl.uniprot.org/uniprot/G3RF09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/9595:NUCB1 ^@ http://purl.uniprot.org/uniprot/G3QU11 ^@ Similarity ^@ Belongs to the nucleobindin family. http://togogenome.org/gene/9595:PANX1 ^@ http://purl.uniprot.org/uniprot/G3QS53 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Membrane|||S-nitrosylation inhibits channel currents and ATP release.|||Structural component of the gap junctions and the hemichannels.|||gap junction http://togogenome.org/gene/9595:HOXA6 ^@ http://purl.uniprot.org/uniprot/G3QIH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9595:YRDC ^@ http://purl.uniprot.org/uniprot/G3QXB2 ^@ Similarity ^@ Belongs to the SUA5 family. http://togogenome.org/gene/9595:AQP3 ^@ http://purl.uniprot.org/uniprot/G3QN14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:PFKFB3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YE16|||http://purl.uniprot.org/uniprot/A0A2I2ZNQ7|||http://purl.uniprot.org/uniprot/A0A2I2ZVY7|||http://purl.uniprot.org/uniprot/A0A2I2ZXU3 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/9595:NPY ^@ http://purl.uniprot.org/uniprot/G3SDV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Secreted http://togogenome.org/gene/9595:NDUFA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TIY1|||http://purl.uniprot.org/uniprot/Q0MQ92 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA2 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:SNX18 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y5F5 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9595:DUOXA1 ^@ http://purl.uniprot.org/uniprot/G3S434 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DUOXA family.|||Membrane http://togogenome.org/gene/9595:ISM1 ^@ http://purl.uniprot.org/uniprot/G3QJR0 ^@ Similarity ^@ Belongs to the isthmin family. http://togogenome.org/gene/9595:LIMD1 ^@ http://purl.uniprot.org/uniprot/G3QJW3 ^@ Similarity ^@ Belongs to the zyxin/ajuba family. http://togogenome.org/gene/9595:ETV5 ^@ http://purl.uniprot.org/uniprot/G3QH11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9595:LOC101129522 ^@ http://purl.uniprot.org/uniprot/G3RK66 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9595:ACYP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YK15|||http://purl.uniprot.org/uniprot/A0A2I2Z424 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/9595:PPIH ^@ http://purl.uniprot.org/uniprot/A0A2I2ZYC9 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9595:GGA2 ^@ http://purl.uniprot.org/uniprot/G3SFF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GGA protein family.|||Early endosome membrane|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9595:SFT2D1 ^@ http://purl.uniprot.org/uniprot/G3RRX9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.|||Membrane http://togogenome.org/gene/9595:HAX1 ^@ http://purl.uniprot.org/uniprot/G3RKT1 ^@ Function|||Similarity ^@ Belongs to the HAX1 family.|||Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. http://togogenome.org/gene/9595:ZDHHC24 ^@ http://purl.uniprot.org/uniprot/G3RIT0 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9595:PPOX ^@ http://purl.uniprot.org/uniprot/G3S5W7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.|||Binds 1 FAD per subunit.|||Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:PARP11 ^@ http://purl.uniprot.org/uniprot/A0A2I2YPT4 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9595:REM1 ^@ http://purl.uniprot.org/uniprot/G3QFA9 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/9595:SLC1A3 ^@ http://purl.uniprot.org/uniprot/G3QPR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9595:SPC25 ^@ http://purl.uniprot.org/uniprot/G3SC48 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the SPC25 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/9595:NRG1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YBR6|||http://purl.uniprot.org/uniprot/A0A2I2ZW64 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neuregulin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Secreted http://togogenome.org/gene/9595:NUP210 ^@ http://purl.uniprot.org/uniprot/G3RNJ2 ^@ Similarity ^@ Belongs to the NUP210 family. http://togogenome.org/gene/9595:LAMTOR5 ^@ http://purl.uniprot.org/uniprot/G3RK57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR5 family.|||Lysosome http://togogenome.org/gene/9595:LGI4 ^@ http://purl.uniprot.org/uniprot/G3RYW9 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9595:HNRNPA2B1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y8M3|||http://purl.uniprot.org/uniprot/G3RLL0 ^@ Subcellular Location Annotation ^@ Cytoplasmic granule http://togogenome.org/gene/9595:ZZZ3 ^@ http://purl.uniprot.org/uniprot/G3R1G6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:TMCO5A ^@ http://purl.uniprot.org/uniprot/G3R7B0|||http://purl.uniprot.org/uniprot/G3SHK0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:MS4A4A ^@ http://purl.uniprot.org/uniprot/G3QIL7 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9595:CPB2 ^@ http://purl.uniprot.org/uniprot/G3QHZ0 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9595:ADAMTS1 ^@ http://purl.uniprot.org/uniprot/G3QWN6 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9595:TEC ^@ http://purl.uniprot.org/uniprot/G3RRV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cytoplasm http://togogenome.org/gene/9595:KHDRBS3 ^@ http://purl.uniprot.org/uniprot/G3QF60 ^@ Similarity ^@ Belongs to the KHDRBS family. http://togogenome.org/gene/9595:SLC44A5 ^@ http://purl.uniprot.org/uniprot/A0A2I2YXU8|||http://purl.uniprot.org/uniprot/G3QVV1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/9595:PLSCR4 ^@ http://purl.uniprot.org/uniprot/G3QUD3 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/9595:DDX4 ^@ http://purl.uniprot.org/uniprot/A0A2I2YQ29|||http://purl.uniprot.org/uniprot/G3QJ22 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9595:MRPS12 ^@ http://purl.uniprot.org/uniprot/G3QJ78 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS12 family. http://togogenome.org/gene/9595:CARTPT ^@ http://purl.uniprot.org/uniprot/G3QQC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CART family.|||Secreted http://togogenome.org/gene/9595:ABCD2 ^@ http://purl.uniprot.org/uniprot/G3R213 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:SEMA6A ^@ http://purl.uniprot.org/uniprot/G3RRP6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:EP300 ^@ http://purl.uniprot.org/uniprot/G3QYU0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:RPL7A ^@ http://purl.uniprot.org/uniprot/G3REU2 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Component of the ribosome. http://togogenome.org/gene/9595:HSF4 ^@ http://purl.uniprot.org/uniprot/G3R8A7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/9595:SLC17A9 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z217|||http://purl.uniprot.org/uniprot/G3QGW1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:GCSH ^@ http://purl.uniprot.org/uniprot/G3QDB8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||Mitochondrion|||The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/9595:PROKR2 ^@ http://purl.uniprot.org/uniprot/G3RE80 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:ATP6V0A2 ^@ http://purl.uniprot.org/uniprot/G3R0Q3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/9595:COQ8A ^@ http://purl.uniprot.org/uniprot/A0A2I2Y561 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family.|||Membrane http://togogenome.org/gene/9595:FAM53C ^@ http://purl.uniprot.org/uniprot/G3QEW6 ^@ Similarity ^@ Belongs to the FAM53 family. http://togogenome.org/gene/9595:ZSCAN22 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZSX9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:HMX2 ^@ http://purl.uniprot.org/uniprot/G3RV99 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:PSAPL1 ^@ http://purl.uniprot.org/uniprot/G3QK07 ^@ Function|||Subcellular Location Annotation ^@ May activate the lysosomal degradation of sphingolipids.|||Secreted http://togogenome.org/gene/9595:BRF2 ^@ http://purl.uniprot.org/uniprot/G3RAU5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:ORMDL2 ^@ http://purl.uniprot.org/uniprot/G3RBN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/9595:SUPT16H ^@ http://purl.uniprot.org/uniprot/G3QIK3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M24 family. SPT16 subfamily.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Component of the FACT complex.|||Nucleus http://togogenome.org/gene/9595:ZP1 ^@ http://purl.uniprot.org/uniprot/G3RCV9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZP domain family. ZPB subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Zona pellucida http://togogenome.org/gene/9595:SNURF ^@ http://purl.uniprot.org/uniprot/A0A2I2YRU9|||http://purl.uniprot.org/uniprot/G3SJP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNURF family.|||Belongs to the snRNP SmB/SmN family.|||Nucleus http://togogenome.org/gene/9595:ADGRA2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1R9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Membrane http://togogenome.org/gene/9595:PAM ^@ http://purl.uniprot.org/uniprot/A0A2I2ZHL5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Binds 2 Cu(2+) ions per subunit.|||Binds one Zn(2+) ion per subunit.|||In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.|||In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.|||Membrane|||secretory vesicle membrane http://togogenome.org/gene/9595:ALDH6A1 ^@ http://purl.uniprot.org/uniprot/G3R112 ^@ Function|||Similarity ^@ Belongs to the aldehyde dehydrogenase family.|||Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA. http://togogenome.org/gene/9595:GRAMD1C ^@ http://purl.uniprot.org/uniprot/G3R234 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:PLCG1 ^@ http://purl.uniprot.org/uniprot/G3QXU1 ^@ Function ^@ Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. http://togogenome.org/gene/9595:LOC101145063 ^@ http://purl.uniprot.org/uniprot/G3SI13 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:KRT6A ^@ http://purl.uniprot.org/uniprot/G3QK06 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:INSL5 ^@ http://purl.uniprot.org/uniprot/G3S062 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/9595:LAMP3 ^@ http://purl.uniprot.org/uniprot/G3QSH2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9595:FAM229A ^@ http://purl.uniprot.org/uniprot/A0A2I2ZJD7 ^@ Similarity ^@ Belongs to the FAM229 family. http://togogenome.org/gene/9595:AP3B2 ^@ http://purl.uniprot.org/uniprot/G3QV79|||http://purl.uniprot.org/uniprot/G3SEA5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes large subunit family.|||Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9595:C1H1orf174 ^@ http://purl.uniprot.org/uniprot/G3RCA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0688 family.|||Nucleus http://togogenome.org/gene/9595:THUMPD2 ^@ http://purl.uniprot.org/uniprot/G3SK58 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/9595:FN1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y9B5|||http://purl.uniprot.org/uniprot/A0A2I2YUM2|||http://purl.uniprot.org/uniprot/A0A2I2Z728|||http://purl.uniprot.org/uniprot/G3RGB3 ^@ Function ^@ Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling. http://togogenome.org/gene/9595:LOC101125081 ^@ http://purl.uniprot.org/uniprot/G3QIQ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9595:LOC101126270 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z6F6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9595:MCM3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZTR8|||http://purl.uniprot.org/uniprot/G3QQN9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/9595:CHN2 ^@ http://purl.uniprot.org/uniprot/G3RAD4 ^@ Function ^@ GTPase-activating protein for p21-rac. http://togogenome.org/gene/9595:LOC101136025 ^@ http://purl.uniprot.org/uniprot/G3SKL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:AOC1 ^@ http://purl.uniprot.org/uniprot/G3QJ02 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the copper/topaquinone oxidase family.|||Contains 1 topaquinone per subunit.|||Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. http://togogenome.org/gene/9595:AVL9 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZID1 ^@ Subcellular Location Annotation ^@ Recycling endosome http://togogenome.org/gene/9595:CA13 ^@ http://purl.uniprot.org/uniprot/G3QTM5 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9595:TIPRL ^@ http://purl.uniprot.org/uniprot/G3RB38 ^@ Similarity ^@ Belongs to the TIP41 family. http://togogenome.org/gene/9595:LOC109023173 ^@ http://purl.uniprot.org/uniprot/G3QF33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:PFN3 ^@ http://purl.uniprot.org/uniprot/G3R2G5 ^@ Similarity ^@ Belongs to the profilin family. http://togogenome.org/gene/9595:NCSTN ^@ http://purl.uniprot.org/uniprot/G3QLU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nicastrin family.|||Membrane http://togogenome.org/gene/9595:HS3ST1 ^@ http://purl.uniprot.org/uniprot/G3RHW4 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9595:POLR1E ^@ http://purl.uniprot.org/uniprot/G3QHM1|||http://purl.uniprot.org/uniprot/G3RMP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.|||nucleolus http://togogenome.org/gene/9595:MMP8 ^@ http://purl.uniprot.org/uniprot/G3R051 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9595:ABITRAM ^@ http://purl.uniprot.org/uniprot/G3QNM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABITRAM family.|||growth cone|||lamellipodium http://togogenome.org/gene/9595:TMEM106A ^@ http://purl.uniprot.org/uniprot/A0A2I2YXP8 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/9595:PDE8A ^@ http://purl.uniprot.org/uniprot/G3RN05 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9595:OOSP2 ^@ http://purl.uniprot.org/uniprot/G3RV37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PLAC1 family.|||Secreted http://togogenome.org/gene/9595:TOR4A ^@ http://purl.uniprot.org/uniprot/A0A2I2ZKQ3 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. Torsin subfamily. http://togogenome.org/gene/9595:NLRP12 ^@ http://purl.uniprot.org/uniprot/A0A2I2YWE6|||http://purl.uniprot.org/uniprot/G3R0J4 ^@ Similarity ^@ Belongs to the NLRP family. http://togogenome.org/gene/9595:PGLYRP3 ^@ http://purl.uniprot.org/uniprot/G3QEY4 ^@ Similarity ^@ Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. http://togogenome.org/gene/9595:SQSTM1 ^@ http://purl.uniprot.org/uniprot/G3RWJ9 ^@ Subcellular Location Annotation ^@ Lysosome|||autophagosome http://togogenome.org/gene/9595:PDIA6 ^@ http://purl.uniprot.org/uniprot/G3QIM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen|||Melanosome http://togogenome.org/gene/9595:TMED9 ^@ http://purl.uniprot.org/uniprot/G3QQX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:TMEM9 ^@ http://purl.uniprot.org/uniprot/A0A2I2YV69|||http://purl.uniprot.org/uniprot/G3QSN9 ^@ Similarity ^@ Belongs to the TMEM9 family. http://togogenome.org/gene/9595:SH3GL1 ^@ http://purl.uniprot.org/uniprot/G3QYS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Membrane http://togogenome.org/gene/9595:ZPR1 ^@ http://purl.uniprot.org/uniprot/G3QEG0 ^@ Similarity ^@ Belongs to the ZPR1 family. http://togogenome.org/gene/9595:TARS1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZBR6 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9595:FOXI1 ^@ http://purl.uniprot.org/uniprot/G3S6N6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:DICER1 ^@ http://purl.uniprot.org/uniprot/G3QMF9 ^@ Function|||Similarity ^@ Belongs to the helicase family. Dicer subfamily.|||Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. http://togogenome.org/gene/9595:TSPAN19 ^@ http://purl.uniprot.org/uniprot/G3RZD4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:GTF2E1 ^@ http://purl.uniprot.org/uniprot/G3S0U4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIE alpha subunit family.|||Nucleus|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. http://togogenome.org/gene/9595:HOXC9 ^@ http://purl.uniprot.org/uniprot/G3QTV8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/9595:IL36A ^@ http://purl.uniprot.org/uniprot/G3RIS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9595:LHCGR ^@ http://purl.uniprot.org/uniprot/G3QZG4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||Membrane|||Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. http://togogenome.org/gene/9595:IL1RAP ^@ http://purl.uniprot.org/uniprot/G3R8P3|||http://purl.uniprot.org/uniprot/G3SCK7 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9595:P2RY11 ^@ http://purl.uniprot.org/uniprot/G3QRQ0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:GFOD2 ^@ http://purl.uniprot.org/uniprot/G3RQ06 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. http://togogenome.org/gene/9595:MPC2 ^@ http://purl.uniprot.org/uniprot/G3SCL4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9595:PTGDS ^@ http://purl.uniprot.org/uniprot/G3QNZ7|||http://purl.uniprot.org/uniprot/Q8WNM1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family.|||Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system (By similarity). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity).|||Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.|||Golgi apparatus|||Monomer.|||Nucleus membrane|||Rough endoplasmic reticulum|||Secreted|||perinuclear region http://togogenome.org/gene/9595:CALR ^@ http://purl.uniprot.org/uniprot/G3RJ55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calreticulin family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9595:LOC101151107 ^@ http://purl.uniprot.org/uniprot/A0A2I2YHN6 ^@ Similarity ^@ Belongs to the NipSnap family. http://togogenome.org/gene/9595:GPR20 ^@ http://purl.uniprot.org/uniprot/G3R4Y1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:PDS5B ^@ http://purl.uniprot.org/uniprot/G3QQJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDS5 family.|||Nucleus http://togogenome.org/gene/9595:NUDT12 ^@ http://purl.uniprot.org/uniprot/G3RRL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Nudix hydrolase family. NudC subfamily.|||Cytoplasmic granule|||Peroxisome http://togogenome.org/gene/9595:TMEM199 ^@ http://purl.uniprot.org/uniprot/G3QPJ7 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:EXTL2 ^@ http://purl.uniprot.org/uniprot/G3QP47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:ERMN ^@ http://purl.uniprot.org/uniprot/G3R383 ^@ Function|||Subunit ^@ Binds actin.|||Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS. http://togogenome.org/gene/9595:SNRPC ^@ http://purl.uniprot.org/uniprot/G3R9U4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the U1 small nuclear ribonucleoprotein C family.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Nucleus|||U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. http://togogenome.org/gene/9595:P3H2 ^@ http://purl.uniprot.org/uniprot/G3R2R6 ^@ Similarity ^@ Belongs to the leprecan family. http://togogenome.org/gene/9595:TNC ^@ http://purl.uniprot.org/uniprot/G3R3R9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tenascin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9595:ABCA4 ^@ http://purl.uniprot.org/uniprot/G3R0D7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:TPRA1 ^@ http://purl.uniprot.org/uniprot/G3R3E5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0359 family.|||Membrane http://togogenome.org/gene/9595:CITED1 ^@ http://purl.uniprot.org/uniprot/G3QDG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CITED family.|||Nucleus http://togogenome.org/gene/9595:FOXS1 ^@ http://purl.uniprot.org/uniprot/G3RMG2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:TAF8 ^@ http://purl.uniprot.org/uniprot/G3R7F5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF8 family.|||Nucleus http://togogenome.org/gene/9595:ULK3 ^@ http://purl.uniprot.org/uniprot/G3QJP8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:RAB39B ^@ http://purl.uniprot.org/uniprot/G3QS29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ATG12 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZEL1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATG12 family.|||Forms a conjugate with ATG5.|||Ubiquitin-like protein involved in autophagic vesicle formation. http://togogenome.org/gene/9595:SCGB1D2 ^@ http://purl.uniprot.org/uniprot/G3SIN4 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9595:SFXN3 ^@ http://purl.uniprot.org/uniprot/G3RHE7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9595:CMTM6 ^@ http://purl.uniprot.org/uniprot/A0A2I2YZ97 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:NRP1 ^@ http://purl.uniprot.org/uniprot/G3QGL8 ^@ Caution|||Similarity ^@ Belongs to the neuropilin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:RAB43 ^@ http://purl.uniprot.org/uniprot/G3QMA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane http://togogenome.org/gene/9595:LOC109025355 ^@ http://purl.uniprot.org/uniprot/A0A2I2YDT2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:F11R ^@ http://purl.uniprot.org/uniprot/G3SFP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9595:MMAA ^@ http://purl.uniprot.org/uniprot/A0A2I2YU07 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. http://togogenome.org/gene/9595:LOC101146261 ^@ http://purl.uniprot.org/uniprot/G3RNU8 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9595:NAXD ^@ http://purl.uniprot.org/uniprot/G3R6K9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NnrD/CARKD family.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Mitochondrion http://togogenome.org/gene/9595:C8B ^@ http://purl.uniprot.org/uniprot/A0A2I2ZW46|||http://purl.uniprot.org/uniprot/G3QZQ6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9595:HIGD1A ^@ http://purl.uniprot.org/uniprot/A0A2I2Z8P0 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/9595:INMT ^@ http://purl.uniprot.org/uniprot/G3QQF8 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. http://togogenome.org/gene/9595:DOLK ^@ http://purl.uniprot.org/uniprot/G3QQ49 ^@ Similarity ^@ Belongs to the polyprenol kinase family. http://togogenome.org/gene/9595:TAFAZZIN ^@ http://purl.uniprot.org/uniprot/G3R8E6|||http://purl.uniprot.org/uniprot/Q6IV83 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acyltransferase required to remodel newly synthesized phospholipid cardiolipin (1',3'-bis-[1,2-diacyl-sn-glycero-3-phospho]-glycerol or CL), a key component of the mitochondrial inner membrane, with tissue specific acyl chains necessary for adequate mitochondrial function (By similarity). Its role in cellular physiology is to improve mitochondrial performance (By similarity). CL is critical for the coassembly of lipids and proteins in mitochondrial membranes, for instance, remodeling of the acyl groups of CL in the mitochondrial inner membrane affects the assembly and stability of respiratory chain complex IV and its supercomplex forms (By similarity). Catalyzes the transacylation between phospholipids and lysophospholipids, with the highest rate being between phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) and CL. Catalyzes both 1-acyl-sn-glycero-3-phosphocholine (lysophosphatidylcholine or LPC) reacylation and PC-CL transacylation, that means, it exchanges acyl groups between CL and PC by a combination of forward and reverse transacylations. Also catalyzes transacylations between other phospholipids such as phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) and CL, between PC and PE, and between PC and phosphatidate (1,2-diacyl-sn-glycero-3-phosphate or PA), although at lower rate. Not regiospecific, it transfers acyl groups into any of the sn-1 and sn-2 positions of the monolysocardiolipin (MLCL), which is an important prerequisite for uniformity and symmetry in CL acyl distribution. Cannot transacylate dilysocardiolipin (DLCL), thus, the role of MLCL is limited to that of an acyl acceptor. CoA-independent, it can reshuffle molecular species within a single phospholipid class. Redistributes fatty acids between MLCL, CL, and other lipids, which prolongs the half-life of CL. Its action is completely reversible, which allows for cyclic changes, such as fission and fusion or bending and flattening of the membrane. Hence, by contributing to the flexibility of the lipid composition, it plays an important role in the dynamics of mitochondria membranes. Essential for the final stage of spermatogenesis, spermatid individualization (By similarity). Required for the initiation of mitophagy (By similarity). Required to ensure progression of spermatocytes through meiosis (By similarity).|||Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis.|||Associates with multiple protein complexes.|||Belongs to the taffazin family.|||Mitochondrion inner membrane|||Mitochondrion outer membrane|||The HXXXXD motif is essential for acyltransferase activity.|||The enzyme was named after a masochistic character Tafazzi, once popular on Italian television, apparently due to the difficulty encountered for its identification and characterization. http://togogenome.org/gene/9595:PSMD11 ^@ http://purl.uniprot.org/uniprot/G3QFG6 ^@ Similarity ^@ Belongs to the proteasome subunit S9 family. http://togogenome.org/gene/9595:FAM174A ^@ http://purl.uniprot.org/uniprot/A0A2I2Y9N3|||http://purl.uniprot.org/uniprot/A0A2I2ZSF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM174 family.|||Membrane http://togogenome.org/gene/9595:DTYMK ^@ http://purl.uniprot.org/uniprot/G3QFV9 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/9595:PACC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z9I5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the proton-activated chloride channel family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:FARS2 ^@ http://purl.uniprot.org/uniprot/G3R851 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Mitochondrion matrix http://togogenome.org/gene/9595:FAT2 ^@ http://purl.uniprot.org/uniprot/G3QU44 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:CHRM3 ^@ http://purl.uniprot.org/uniprot/Q9N2A3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Basolateral cell membrane|||Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM3 sub-subfamily.|||Cell membrane|||Endoplasmic reticulum membrane|||Homodimer; the dimers can form tetramers (By similarity). Interacts with NALCN (By similarity). Interacts with TMEM147 (By similarity).|||Postsynaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity). http://togogenome.org/gene/9595:LSM1 ^@ http://purl.uniprot.org/uniprot/G3S9N7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Cytoplasm|||Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.|||P-body|||Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. http://togogenome.org/gene/9595:HADHA ^@ http://purl.uniprot.org/uniprot/G3SJ02 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9595:IGFBP3 ^@ http://purl.uniprot.org/uniprot/G3QGS3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9595:CCR5 ^@ http://purl.uniprot.org/uniprot/P56439|||http://purl.uniprot.org/uniprot/Q549B2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with PRAF2. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with GRK2. Interacts with ARRB1 and ARRB2. Interacts with CNIH4. Interacts with S100A4; this interaction stimulates T-lymphocyte chemotaxis.|||O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site even if Ser-7 may be also O-glycosylated. Also sialylated glycans present which contribute to chemokine binding. Thr-16 and Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen.|||Palmitoylation in the C-terminal is important for cell surface expression.|||Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES.|||Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.|||Sulfated on at least 2 of the N-terminal tyrosines. Sulfation is required for efficient binding of the chemokines, CCL3 and CCL4 (By similarity). http://togogenome.org/gene/9595:VGLL3 ^@ http://purl.uniprot.org/uniprot/G3R238 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs.|||Nucleus http://togogenome.org/gene/9595:TBC1D23 ^@ http://purl.uniprot.org/uniprot/A0A2I2YN88|||http://purl.uniprot.org/uniprot/A0A2I2ZCF2 ^@ Subcellular Location Annotation ^@ trans-Golgi network http://togogenome.org/gene/9595:CARMIL3 ^@ http://purl.uniprot.org/uniprot/G3RIQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CARMIL family.|||Cytoplasm http://togogenome.org/gene/9595:ALX1 ^@ http://purl.uniprot.org/uniprot/G3QD58 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:PRDX5 ^@ http://purl.uniprot.org/uniprot/G3QG68 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxiredoxin family. Prx5 subfamily.|||Peroxisome matrix|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. http://togogenome.org/gene/9595:SMOC1 ^@ http://purl.uniprot.org/uniprot/G3S8N9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:PLLP ^@ http://purl.uniprot.org/uniprot/G3RTG2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:KIF3B ^@ http://purl.uniprot.org/uniprot/G3RAF7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9595:CMTM8 ^@ http://purl.uniprot.org/uniprot/G3QT92 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:GABRA6 ^@ http://purl.uniprot.org/uniprot/G3QET0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9595:BCAP31 ^@ http://purl.uniprot.org/uniprot/G3QS23 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCAP29/BCAP31 family.|||Endoplasmic reticulum membrane|||Membrane|||Plays a role in the export of secreted proteins in the ER. http://togogenome.org/gene/9595:LOC109028109 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z289 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9595:TIMP3 ^@ http://purl.uniprot.org/uniprot/G3RBQ3 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/9595:MPPE1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YXR5|||http://purl.uniprot.org/uniprot/G3QDC7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metallophosphoesterase superfamily. MPPE1 family.|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Interacts with GPI-anchor proteins. Interacts with TMED10.|||Membrane|||Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.|||cis-Golgi network membrane http://togogenome.org/gene/9595:GSTP1 ^@ http://purl.uniprot.org/uniprot/G3SEU1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GST superfamily. Pi family.|||Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.|||Cytoplasm|||Homodimer.|||Mitochondrion|||Nucleus http://togogenome.org/gene/9595:YIF1B ^@ http://purl.uniprot.org/uniprot/A0A2I2YFZ0|||http://purl.uniprot.org/uniprot/A0A2I2ZK95 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIF1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Has a role in transport between endoplasmic reticulum and Golgi.|||Membrane http://togogenome.org/gene/9595:SLX1A ^@ http://purl.uniprot.org/uniprot/G3RAE4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SLX1 family.|||Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.|||Forms a heterodimer with SLX4.|||Nucleus http://togogenome.org/gene/9595:PISD ^@ http://purl.uniprot.org/uniprot/G3QXV3 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.|||Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:TMED10 ^@ http://purl.uniprot.org/uniprot/G3RRB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:LAMB1 ^@ http://purl.uniprot.org/uniprot/G3R5A1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/9595:FDXR ^@ http://purl.uniprot.org/uniprot/A0A2I2YYN2|||http://purl.uniprot.org/uniprot/G3QLA1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferredoxin--NADP reductase type 1 family.|||Mitochondrion|||Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. http://togogenome.org/gene/9595:GTF2E2 ^@ http://purl.uniprot.org/uniprot/G3RZT0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFIIE beta subunit family.|||Nucleus|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.|||Tetramer of two alpha and two beta chains. http://togogenome.org/gene/9595:PRKG1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YA88|||http://purl.uniprot.org/uniprot/A0A2I2ZKF7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily. http://togogenome.org/gene/9595:HRH1 ^@ http://purl.uniprot.org/uniprot/Q9N2B1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.|||Phosphorylation at sites in the second and third cytoplasmic loops independently contribute to agonist-induced receptor down-regulation. http://togogenome.org/gene/9595:TMEM132D ^@ http://purl.uniprot.org/uniprot/G3R039 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM132 family.|||Membrane http://togogenome.org/gene/9595:CETP ^@ http://purl.uniprot.org/uniprot/G3QGV3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.|||Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL.|||Secreted http://togogenome.org/gene/9595:TMA7 ^@ http://purl.uniprot.org/uniprot/G3S1Z1 ^@ Similarity ^@ Belongs to the TMA7 family. http://togogenome.org/gene/9595:CCL19 ^@ http://purl.uniprot.org/uniprot/G3QKB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9595:LOC101144123 ^@ http://purl.uniprot.org/uniprot/A0A2I2YSY1 ^@ Similarity ^@ Belongs to the RIMBP family. http://togogenome.org/gene/9595:PRLR ^@ http://purl.uniprot.org/uniprot/A0A2I2YN87 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||Interacts with SMARCA1. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.|||Membrane|||The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.|||The box 1 motif is required for JAK interaction and/or activation.|||This is a receptor for the anterior pituitary hormone prolactin. http://togogenome.org/gene/9595:FADS3 ^@ http://purl.uniprot.org/uniprot/G3R9K5 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:TCP1 ^@ http://purl.uniprot.org/uniprot/G3RDV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||centrosome http://togogenome.org/gene/9595:PLA2G3 ^@ http://purl.uniprot.org/uniprot/G3RX58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Secreted http://togogenome.org/gene/9595:TAS2R10 ^@ http://purl.uniprot.org/uniprot/G3R3K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9595:GABRG3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZXT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9595:OTX1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YNC9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:PAX1 ^@ http://purl.uniprot.org/uniprot/G3RJ10 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SLC39A12 ^@ http://purl.uniprot.org/uniprot/G3RHH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Membrane http://togogenome.org/gene/9595:PGM2 ^@ http://purl.uniprot.org/uniprot/G3SGU6 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/9595:DPH5 ^@ http://purl.uniprot.org/uniprot/G3RMY5 ^@ Function|||Similarity ^@ Belongs to the diphthine synthase family.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/9595:SV2B ^@ http://purl.uniprot.org/uniprot/G3RFJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/9595:SERPINA4 ^@ http://purl.uniprot.org/uniprot/G3RLE0 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9595:ARMC8 ^@ http://purl.uniprot.org/uniprot/G3RV63 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9595:MS4A15 ^@ http://purl.uniprot.org/uniprot/G3R845 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9595:GAMT ^@ http://purl.uniprot.org/uniprot/G3QK08 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.|||Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor.|||Monomer. http://togogenome.org/gene/9595:HSD17B13 ^@ http://purl.uniprot.org/uniprot/G3QKD0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9595:GRK6 ^@ http://purl.uniprot.org/uniprot/G3R2J6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9595:FZD9 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZM69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ETFB ^@ http://purl.uniprot.org/uniprot/G3R168|||http://purl.uniprot.org/uniprot/G3SIW7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ETF beta-subunit/FixA family.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion matrix|||The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). http://togogenome.org/gene/9595:NIM1K ^@ http://purl.uniprot.org/uniprot/G3QFP4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:CCR2 ^@ http://purl.uniprot.org/uniprot/G3RP68 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:AFM ^@ http://purl.uniprot.org/uniprot/G3RCD3 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9595:TGFB1 ^@ http://purl.uniprot.org/uniprot/G3SE85 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.|||extracellular matrix http://togogenome.org/gene/9595:SBK3 ^@ http://purl.uniprot.org/uniprot/G3SHI9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:PPARGC1A ^@ http://purl.uniprot.org/uniprot/G3R2X2 ^@ Subcellular Location Annotation ^@ PML body http://togogenome.org/gene/9595:MAP3K7 ^@ http://purl.uniprot.org/uniprot/G3RXU7 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation.|||Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Cytoplasm http://togogenome.org/gene/9595:KCNK12 ^@ http://purl.uniprot.org/uniprot/A0A2I2YZD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9595:LOC101132458 ^@ http://purl.uniprot.org/uniprot/G3RZJ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCRH/QCR6 family.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:FOXN4 ^@ http://purl.uniprot.org/uniprot/G3R1N1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:ERBB2 ^@ http://purl.uniprot.org/uniprot/G3QPD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/9595:ERG ^@ http://purl.uniprot.org/uniprot/A0A2I2YSF9|||http://purl.uniprot.org/uniprot/A0A2I2ZDB4|||http://purl.uniprot.org/uniprot/G3R6Y6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9595:BRMS1L ^@ http://purl.uniprot.org/uniprot/G3QU57 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:ANKH ^@ http://purl.uniprot.org/uniprot/A0A2I2ZWN9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANKH family.|||Membrane|||Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter. http://togogenome.org/gene/9595:UCK1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YLV8|||http://purl.uniprot.org/uniprot/A0A2I2Z2K5 ^@ Similarity ^@ Belongs to the uridine kinase family. http://togogenome.org/gene/9595:SFT2D2 ^@ http://purl.uniprot.org/uniprot/G3S316 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.|||Membrane http://togogenome.org/gene/9595:CDC25A ^@ http://purl.uniprot.org/uniprot/A0A2I2YPZ4|||http://purl.uniprot.org/uniprot/G3S7V2 ^@ Function|||Similarity ^@ Belongs to the MPI phosphatase family.|||Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. http://togogenome.org/gene/9595:CCT8 ^@ http://purl.uniprot.org/uniprot/G3QU21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||cilium basal body http://togogenome.org/gene/9595:GABRR1 ^@ http://purl.uniprot.org/uniprot/G3RJC9|||http://purl.uniprot.org/uniprot/G3RXD5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9595:GAB1 ^@ http://purl.uniprot.org/uniprot/G3QCS4 ^@ Similarity ^@ Belongs to the GAB family. http://togogenome.org/gene/9595:MTM1 ^@ http://purl.uniprot.org/uniprot/G3RAB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/9595:CPA6 ^@ http://purl.uniprot.org/uniprot/G3QSV0 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9595:RAB3B ^@ http://purl.uniprot.org/uniprot/G3QGS6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/9595:F8 ^@ http://purl.uniprot.org/uniprot/G3QM23 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/9595:FUT9 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZMW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9595:LOC101153542 ^@ http://purl.uniprot.org/uniprot/G3RAV9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:DPH6 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZDW5|||http://purl.uniprot.org/uniprot/G3RHL7 ^@ Function|||Similarity ^@ Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.|||Belongs to the Diphthine--ammonia ligase family. http://togogenome.org/gene/9595:TAF10 ^@ http://purl.uniprot.org/uniprot/A0A2I2YXR6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF10 family.|||Nucleus|||The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. http://togogenome.org/gene/9595:LOC101154556 ^@ http://purl.uniprot.org/uniprot/G3R7J7 ^@ Function|||Subcellular Location Annotation ^@ Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:PFN4 ^@ http://purl.uniprot.org/uniprot/G3RUG6 ^@ Similarity ^@ Belongs to the profilin family. http://togogenome.org/gene/9595:NAA25 ^@ http://purl.uniprot.org/uniprot/G3QW63 ^@ Similarity ^@ Belongs to the MDM20/NAA25 family. http://togogenome.org/gene/9595:ASIC3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YA49|||http://purl.uniprot.org/uniprot/G3RL27 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:C12H12orf57 ^@ http://purl.uniprot.org/uniprot/G3QNR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0456 family.|||Cytoplasm http://togogenome.org/gene/9595:GJC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZQJ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins. Interacts with CNST.|||Belongs to the connexin family. Gamma-type subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9595:MPC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z5H9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9595:LOC101136923 ^@ http://purl.uniprot.org/uniprot/G3SBQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:RSBN1L ^@ http://purl.uniprot.org/uniprot/G3QVW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the round spermatid basic protein 1 family.|||Nucleus http://togogenome.org/gene/9595:ABI1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZA54|||http://purl.uniprot.org/uniprot/A0A2I2ZHH5|||http://purl.uniprot.org/uniprot/G3R7N7|||http://purl.uniprot.org/uniprot/G3RZG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABI family.|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/9595:GPR65 ^@ http://purl.uniprot.org/uniprot/G3RXN3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:ATG2B ^@ http://purl.uniprot.org/uniprot/G3RCD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG2 family.|||Endoplasmic reticulum membrane|||Lipid droplet|||Preautophagosomal structure membrane http://togogenome.org/gene/9595:WNT5A ^@ http://purl.uniprot.org/uniprot/G3QWY6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9595:IL5 ^@ http://purl.uniprot.org/uniprot/G3RWE7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-5 family.|||Homodimer; disulfide-linked.|||Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively.|||Secreted http://togogenome.org/gene/9595:CA14 ^@ http://purl.uniprot.org/uniprot/G3RLP6 ^@ Similarity ^@ Belongs to the alpha-carbonic anhydrase family. http://togogenome.org/gene/9595:DDB2 ^@ http://purl.uniprot.org/uniprot/G3QZR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat DDB2/WDR76 family.|||Nucleus http://togogenome.org/gene/9595:CAV1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TIY4|||http://purl.uniprot.org/uniprot/Q2IBF0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||Homooligomer. Interacts (via the N-terminus) with DPP4; the interaction is direct. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Interacts with PACSIN2; this interaction induces membrane tubulation (By similarity). Interacts with BMX, BTK, CTNNB1, CDH1, GLIPR2, JUP, NOSTRIN, SNAP25 and STX1A. Interacts with SLC7A9. Interacts with TGFBR1. Interacts with CAVIN3 (via leucine-zipper domain) in a cholesterol-sensitive manner. Interacts with CAVIN1. Interacts with EHD2 in a cholesterol-dependent manner. Forms a ternary complex with UBXN6 and VCP; mediates CAV1 targeting to lysosomes for degradation. Interacts with ABCG1; this interaction regulates ABCG1-mediated cholesterol efflux (By similarity). Interacts with NEU3; this interaction enhances NEU3 sialidase activity within caveola. Interacts (via C-terminus) with SPRY1, SPRY2 (via C-terminus), SPRY3, and SPRY4 (By similarity).|||May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity).|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||Membrane raft|||Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.|||Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination. Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation. Ubiquitinated by ZNRF1; leading to degradation and modulation of the TLR4-mediated immune response.|||caveola http://togogenome.org/gene/9595:MED19 ^@ http://purl.uniprot.org/uniprot/G3RN27 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 19 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9595:CWC25 ^@ http://purl.uniprot.org/uniprot/G3QVZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CWC25 family.|||Nucleus http://togogenome.org/gene/9595:CD99L2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YBL0|||http://purl.uniprot.org/uniprot/G3RN63 ^@ Similarity ^@ Belongs to the CD99 family. http://togogenome.org/gene/9595:LOC101127406 ^@ http://purl.uniprot.org/uniprot/G3QM51 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9595:TMEM183A ^@ http://purl.uniprot.org/uniprot/G3R2Z3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM183 family.|||Membrane http://togogenome.org/gene/9595:EIF2D ^@ http://purl.uniprot.org/uniprot/A0A2I2ZR02|||http://purl.uniprot.org/uniprot/G3RGZ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF2D family.|||Cytoplasm|||Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. http://togogenome.org/gene/9595:TSPAN33 ^@ http://purl.uniprot.org/uniprot/G3S9J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9595:GINS4 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZYR7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GINS4/SLD5 family.|||Chromosome|||Nucleus|||Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. http://togogenome.org/gene/9595:FGFR4 ^@ http://purl.uniprot.org/uniprot/G3RPD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:RRP8 ^@ http://purl.uniprot.org/uniprot/G3QDQ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methyltransferase superfamily. RRP8 family.|||Component of the eNoSC complex.|||Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase.|||nucleolus http://togogenome.org/gene/9595:CKLF ^@ http://purl.uniprot.org/uniprot/G3SGW3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:TRAF5 ^@ http://purl.uniprot.org/uniprot/G3RAK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/9595:SLC34A2 ^@ http://purl.uniprot.org/uniprot/G3SH16 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the SLC34A transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:MBOAT7 ^@ http://purl.uniprot.org/uniprot/G3RTU0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:HAPLN4 ^@ http://purl.uniprot.org/uniprot/G3QKF6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:RHBDF2 ^@ http://purl.uniprot.org/uniprot/G3RHH8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S54 family.|||Endoplasmic reticulum membrane|||Membrane|||Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. http://togogenome.org/gene/9595:SLC33A1 ^@ http://purl.uniprot.org/uniprot/G3RB72 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:MYCL ^@ http://purl.uniprot.org/uniprot/G3QH47 ^@ Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Nucleus http://togogenome.org/gene/9595:KCNK7 ^@ http://purl.uniprot.org/uniprot/G3R7Y0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9595:PPY ^@ http://purl.uniprot.org/uniprot/G3RAQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Secreted http://togogenome.org/gene/9595:GLUL ^@ http://purl.uniprot.org/uniprot/G3SJV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamine synthetase family.|||Cell membrane|||Membrane|||Microsome|||Mitochondrion http://togogenome.org/gene/9595:XDH ^@ http://purl.uniprot.org/uniprot/G3R727 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters.|||Homodimer. Interacts with BTN1A1.|||Peroxisome http://togogenome.org/gene/9595:NMNAT2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZG10 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/9595:CLCN6 ^@ http://purl.uniprot.org/uniprot/G3SCD3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:NDUFB11 ^@ http://purl.uniprot.org/uniprot/Q0MQJ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB11 subunit family.|||Complex I is composed of 45 different subunits. Interacts with BCAP31.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:ATP1A2 ^@ http://purl.uniprot.org/uniprot/G3S409 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:CSNK2A1 ^@ http://purl.uniprot.org/uniprot/G3RVT9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:NAP1L4 ^@ http://purl.uniprot.org/uniprot/A0A2I2YBN5 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9595:MRPL50 ^@ http://purl.uniprot.org/uniprot/G3SHW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL50 family.|||Mitochondrion http://togogenome.org/gene/9595:NT5DC1 ^@ http://purl.uniprot.org/uniprot/G3QWY4 ^@ Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family. http://togogenome.org/gene/9595:SLC39A3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YG18 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:MED4 ^@ http://purl.uniprot.org/uniprot/G3RE20 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 4 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9595:GPR137B ^@ http://purl.uniprot.org/uniprot/G3QT50 ^@ Subcellular Location Annotation ^@ Lysosome membrane|||Membrane http://togogenome.org/gene/9595:BRIX1 ^@ http://purl.uniprot.org/uniprot/G3QNM9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BRX1 family.|||Required for biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/9595:LOC101134485 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z6F9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:UFL1 ^@ http://purl.uniprot.org/uniprot/G3RD68 ^@ Similarity ^@ Belongs to the UFL1 family. http://togogenome.org/gene/9595:OSGEP ^@ http://purl.uniprot.org/uniprot/G3QI87 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:ERGIC3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZED1|||http://purl.uniprot.org/uniprot/G3S6Z8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/9595:ZFTRAF1 ^@ http://purl.uniprot.org/uniprot/G3RJG2 ^@ Similarity ^@ Belongs to the ZFTRAF1 family. http://togogenome.org/gene/9595:GPD2 ^@ http://purl.uniprot.org/uniprot/G3RU77 ^@ Function|||Similarity ^@ Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.|||Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device. http://togogenome.org/gene/9595:ATG4A ^@ http://purl.uniprot.org/uniprot/G3RTG5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/9595:RDX ^@ http://purl.uniprot.org/uniprot/A0A2I2YBU5 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/9595:TMEM167B ^@ http://purl.uniprot.org/uniprot/A0A2I2ZV03 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KISH family.|||Golgi apparatus membrane|||Involved in the early part of the secretory pathway.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:MARCHF4 ^@ http://purl.uniprot.org/uniprot/G3QD63 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:NINJ1 ^@ http://purl.uniprot.org/uniprot/G3RN89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ninjurin family.|||Membrane http://togogenome.org/gene/9595:CHGA ^@ http://purl.uniprot.org/uniprot/G3SJY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromogranin/secretogranin protein family.|||Secreted http://togogenome.org/gene/9595:SEM1 ^@ http://purl.uniprot.org/uniprot/G3S3V4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DSS1/SEM1 family.|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.|||Nucleus http://togogenome.org/gene/9595:TCEANC2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZSS0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:WFDC12 ^@ http://purl.uniprot.org/uniprot/A4K2R5 ^@ Function|||Subcellular Location Annotation ^@ Antibacterial protein. Putative acid-stable proteinase inhibitor (By similarity).|||Secreted http://togogenome.org/gene/9595:TUBA8 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y1Q4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9595:ARSB ^@ http://purl.uniprot.org/uniprot/A0A2I2YTP9 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9595:UROD ^@ http://purl.uniprot.org/uniprot/G3QGP9|||http://purl.uniprot.org/uniprot/G3SGL6 ^@ Similarity|||Subunit ^@ Belongs to the uroporphyrinogen decarboxylase family.|||Homodimer. http://togogenome.org/gene/9595:TIMP4 ^@ http://purl.uniprot.org/uniprot/G3R2S3 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/9595:FICD ^@ http://purl.uniprot.org/uniprot/G3R7D2 ^@ Similarity ^@ Belongs to the fic family. http://togogenome.org/gene/9595:TMEM201 ^@ http://purl.uniprot.org/uniprot/G3QV62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM201 family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/9595:PSPH ^@ http://purl.uniprot.org/uniprot/G3RH53 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. SerB family. http://togogenome.org/gene/9595:CFL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZWK6|||http://purl.uniprot.org/uniprot/G3RMM9 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. http://togogenome.org/gene/9595:NSUN3 ^@ http://purl.uniprot.org/uniprot/G3RBS6 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/9595:ZSCAN20 ^@ http://purl.uniprot.org/uniprot/G3QSE2 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9595:TIMM22 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y419 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM22 complex.|||Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9595:GRHL1 ^@ http://purl.uniprot.org/uniprot/G3QJQ4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:ACTL7A ^@ http://purl.uniprot.org/uniprot/G3S9F1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the actin family.|||Golgi apparatus|||May play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis.|||Nucleus|||cytoskeleton http://togogenome.org/gene/9595:PDE7A ^@ http://purl.uniprot.org/uniprot/G3SFP7 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9595:PIF1 ^@ http://purl.uniprot.org/uniprot/G3S8K9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the helicase family. PIF1 subfamily.|||DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity.|||Mitochondrion|||Monomer. Interacts with telomerase.|||Nucleus http://togogenome.org/gene/9595:LOC101149806 ^@ http://purl.uniprot.org/uniprot/G3S4Y3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9595:TRIM56 ^@ http://purl.uniprot.org/uniprot/G3QDS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm http://togogenome.org/gene/9595:POLR3F ^@ http://purl.uniprot.org/uniprot/G3R7C7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/9595:SLC10A6 ^@ http://purl.uniprot.org/uniprot/G3QX25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/9595:TAC4 ^@ http://purl.uniprot.org/uniprot/G3QWZ2 ^@ Similarity ^@ Belongs to the tachykinin family. http://togogenome.org/gene/9595:NR4A1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YDL5|||http://purl.uniprot.org/uniprot/A0A2I2Z5G2|||http://purl.uniprot.org/uniprot/G3SE60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR4 subfamily.|||In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7.|||Nucleus|||cytosol http://togogenome.org/gene/9595:PTK7 ^@ http://purl.uniprot.org/uniprot/G3R4V7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:PBX1 ^@ http://purl.uniprot.org/uniprot/G3R6Q4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/PBX homeobox family.|||Nucleus http://togogenome.org/gene/9595:BAAT ^@ http://purl.uniprot.org/uniprot/G3RHU9 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/9595:CNOT1 ^@ http://purl.uniprot.org/uniprot/G3R2A2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT1 family.|||Nucleus http://togogenome.org/gene/9595:FAM83G ^@ http://purl.uniprot.org/uniprot/G3RAE3 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9595:ITGB1 ^@ http://purl.uniprot.org/uniprot/G3QTG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:LOC101148343 ^@ http://purl.uniprot.org/uniprot/G3S0S4 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9595:TMPRSS11A ^@ http://purl.uniprot.org/uniprot/G3R9V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Membrane http://togogenome.org/gene/9595:LITAF ^@ http://purl.uniprot.org/uniprot/A0A2I2YKF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/9595:HEBP1 ^@ http://purl.uniprot.org/uniprot/G3QF27 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/9595:TMEM245 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZYY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/9595:CDK2AP2 ^@ http://purl.uniprot.org/uniprot/G3R3T4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDK2AP family.|||Nucleus http://togogenome.org/gene/9595:TAFA1 ^@ http://purl.uniprot.org/uniprot/G3R7U2 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/9595:RORC ^@ http://purl.uniprot.org/uniprot/G3RVZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9595:CA9 ^@ http://purl.uniprot.org/uniprot/A0A2I2YMA5 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9595:FAM110A ^@ http://purl.uniprot.org/uniprot/G3RAH6 ^@ Similarity ^@ Belongs to the FAM110 family. http://togogenome.org/gene/9595:LOC101126932 ^@ http://purl.uniprot.org/uniprot/P02024 ^@ Function|||Similarity|||Subunit|||Tissue Specificity ^@ Belongs to the globin family.|||Heterotetramer of two alpha chains and two beta chains.|||Involved in oxygen transport from the lung to the various peripheral tissues.|||Red blood cells. http://togogenome.org/gene/9595:IL1RN ^@ http://purl.uniprot.org/uniprot/A0A2I2YA94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9595:TIMM8A ^@ http://purl.uniprot.org/uniprot/G3S6N4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9595:CLDN11 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZIY0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9595:PARPBP ^@ http://purl.uniprot.org/uniprot/A0A2I2YQ07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PARI family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:LRP8 ^@ http://purl.uniprot.org/uniprot/A0A2I2YGF2|||http://purl.uniprot.org/uniprot/A0A2I2ZJL4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:SLC39A10 ^@ http://purl.uniprot.org/uniprot/A0A2I2YX43 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:TFEB ^@ http://purl.uniprot.org/uniprot/G3QJP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/9595:SEPTIN3 ^@ http://purl.uniprot.org/uniprot/G3R0S2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cytoplasm|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9595:UBN2 ^@ http://purl.uniprot.org/uniprot/G3QPE0 ^@ Similarity ^@ Belongs to the ubinuclein family. http://togogenome.org/gene/9595:ACSL6 ^@ http://purl.uniprot.org/uniprot/A0A2I2YTF5|||http://purl.uniprot.org/uniprot/A0A2I2Z156 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion outer membrane http://togogenome.org/gene/9595:IFT57 ^@ http://purl.uniprot.org/uniprot/G3QVA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFT57 family.|||cilium basal body http://togogenome.org/gene/9595:VWC2L ^@ http://purl.uniprot.org/uniprot/G3RJ39 ^@ Subcellular Location Annotation ^@ Synapse http://togogenome.org/gene/9595:TIMM17A ^@ http://purl.uniprot.org/uniprot/G3QZB6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9595:LOC101133052 ^@ http://purl.uniprot.org/uniprot/G3RPG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MHC class I family.|||Endosome membrane|||Lysosome membrane http://togogenome.org/gene/9595:AGT ^@ http://purl.uniprot.org/uniprot/Q9GLP6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Acts by binding to angiotensin receptors AGTR1 and AGTR2. Also binds the DEAR/FBXW7-AS1 receptor.|||Belongs to the serpin family.|||Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.|||In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin) (By similarity).|||Is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.|||Secreted|||Stimulates aldosterone release.|||The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin (By similarity). http://togogenome.org/gene/9595:TMPRSS2 ^@ http://purl.uniprot.org/uniprot/G3SFM5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:SCGN ^@ http://purl.uniprot.org/uniprot/G3QEN6 ^@ Subcellular Location Annotation ^@ secretory vesicle membrane http://togogenome.org/gene/9595:TPRG1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z4N0 ^@ Similarity ^@ Belongs to the TPRG1 family. http://togogenome.org/gene/9595:KCNJ14 ^@ http://purl.uniprot.org/uniprot/G3RC96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9595:PHKB ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1V1|||http://purl.uniprot.org/uniprot/A0A2I2Z262|||http://purl.uniprot.org/uniprot/G3QKJ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphorylase b kinase regulatory chain family.|||Cell membrane|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.|||Membrane|||Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. http://togogenome.org/gene/9595:MAP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZUJ7|||http://purl.uniprot.org/uniprot/G3RLX2 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9595:RARRES2 ^@ http://purl.uniprot.org/uniprot/G3R6C5 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9595:HAPLN1 ^@ http://purl.uniprot.org/uniprot/G3SAS2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:SYNPR ^@ http://purl.uniprot.org/uniprot/G3QJ88|||http://purl.uniprot.org/uniprot/G3RUY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/9595:MRPS25 ^@ http://purl.uniprot.org/uniprot/G3R5Y9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS25 family.|||Mitochondrion http://togogenome.org/gene/9595:HGS ^@ http://purl.uniprot.org/uniprot/G3R1Q6 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Early endosome membrane|||Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.|||multivesicular body membrane http://togogenome.org/gene/9595:HOOK1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZFL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hook family.|||cytoskeleton http://togogenome.org/gene/9595:CAV2 ^@ http://purl.uniprot.org/uniprot/Q2IBF3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the caveolin family.|||Cell membrane|||Cytoplasm|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).|||Monomer or homodimer (By similarity). Interacts with CAV1; the interaction forms a stable heterooligomeric complex that is required for targeting to lipid rafts and for caveolae formation. Tyrosine phosphorylated forms do not form heterooligomers with the Tyr-19-phosphorylated form existing as a monomer or dimer, and the Tyr-27-form as a monomer only. Interacts (tyrosine phosphorylated form) with the SH2 domain-containing proteins, RASA1, NCK1 and SRC. Interacts (tyrosine phosphorylated form) with INSR, the interaction (Tyr-27-phosphorylated form) is increased on insulin stimulation. Interacts (Tyr-19 phosphorylated form) with MAPK1 (phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with STAT3; the interaction is increased on insulin-induced tyrosine phosphorylation leading to STAT activation (By similarity).|||Nucleus|||Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells (By similarity). Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced 'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin (By. similarity).|||caveola http://togogenome.org/gene/9595:LY6D ^@ http://purl.uniprot.org/uniprot/G3RKS8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:RAD17 ^@ http://purl.uniprot.org/uniprot/G3RHP7|||http://purl.uniprot.org/uniprot/G3RR37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad17/RAD24 family.|||Nucleus http://togogenome.org/gene/9595:ALDH3B1 ^@ http://purl.uniprot.org/uniprot/G3S3W6 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9595:BBOX1 ^@ http://purl.uniprot.org/uniprot/G3R1Y7 ^@ Function|||Similarity ^@ Belongs to the gamma-BBH/TMLD family.|||Catalyzes the formation of L-carnitine from gamma-butyrobetaine. http://togogenome.org/gene/9595:SHMT2 ^@ http://purl.uniprot.org/uniprot/G3R410 ^@ Function|||Similarity ^@ Belongs to the SHMT family.|||Interconversion of serine and glycine. http://togogenome.org/gene/9595:MTHFR ^@ http://purl.uniprot.org/uniprot/A0A2I2Y6Y9 ^@ Similarity ^@ Belongs to the methylenetetrahydrofolate reductase family. http://togogenome.org/gene/9595:FABP4 ^@ http://purl.uniprot.org/uniprot/G3QWM2 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9595:SLC13A3 ^@ http://purl.uniprot.org/uniprot/G3QP81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/9595:FGA ^@ http://purl.uniprot.org/uniprot/G3RWD8 ^@ Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted http://togogenome.org/gene/9595:SNRPB ^@ http://purl.uniprot.org/uniprot/G3S6A6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP SmB/SmN family.|||Nucleus http://togogenome.org/gene/9595:ASB4 ^@ http://purl.uniprot.org/uniprot/G3QUG4 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9595:RSPO2 ^@ http://purl.uniprot.org/uniprot/G3S4G7 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/9595:ULK2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z864 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.|||Serine/threonine-protein kinase involved in autophagy in response to starvation. http://togogenome.org/gene/9595:MAN2B2 ^@ http://purl.uniprot.org/uniprot/G3QYG2 ^@ Cofactor|||Similarity ^@ Belongs to the glycosyl hydrolase 38 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9595:SEZ6L ^@ http://purl.uniprot.org/uniprot/G3QQK8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:GALNT1 ^@ http://purl.uniprot.org/uniprot/G3QVC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:APOA2 ^@ http://purl.uniprot.org/uniprot/P0DJG2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the apolipoprotein A2 family.|||Homodimer; disulfide-linked (PubMed:21298813). Interacts with NAXE and NDRG1 (By similarity).|||May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.|||Plasma.|||Secreted http://togogenome.org/gene/9595:POGLUT3 ^@ http://purl.uniprot.org/uniprot/G3R4Z5 ^@ Similarity ^@ Belongs to the KDELC family. http://togogenome.org/gene/9595:PLIN3 ^@ http://purl.uniprot.org/uniprot/G3S2C7 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/9595:EVX1 ^@ http://purl.uniprot.org/uniprot/G3RR05 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:MIDN ^@ http://purl.uniprot.org/uniprot/G3S8C0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SIAH3 ^@ http://purl.uniprot.org/uniprot/G3QHJ8 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/9595:IDE ^@ http://purl.uniprot.org/uniprot/A0A2I2Z3K6|||http://purl.uniprot.org/uniprot/G3R5E6 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/9595:EDEM1 ^@ http://purl.uniprot.org/uniprot/G3QI15 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9595:SLC8A3 ^@ http://purl.uniprot.org/uniprot/G3RTP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:TACR3 ^@ http://purl.uniprot.org/uniprot/G3QJF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:TTC38 ^@ http://purl.uniprot.org/uniprot/G3QFK0 ^@ Similarity ^@ Belongs to the TTC38 family. http://togogenome.org/gene/9595:ZDHHC6 ^@ http://purl.uniprot.org/uniprot/G3SHQ9 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Endoplasmic reticulum membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9595:ALDH1A1 ^@ http://purl.uniprot.org/uniprot/G3QZR0 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9595:GOSR1 ^@ http://purl.uniprot.org/uniprot/G3S538 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GOSR1 family.|||Component of several multiprotein Golgi SNARE complexes.|||Golgi apparatus membrane|||Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.|||Membrane http://togogenome.org/gene/9595:FGF12 ^@ http://purl.uniprot.org/uniprot/A0A2I2YDP8|||http://purl.uniprot.org/uniprot/A0A2I2YRP7 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9595:SLC13A4 ^@ http://purl.uniprot.org/uniprot/G3QDP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/9595:B9D1 ^@ http://purl.uniprot.org/uniprot/G3QFK5|||http://purl.uniprot.org/uniprot/G3SJC3 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/9595:LETMD1 ^@ http://purl.uniprot.org/uniprot/G3R8T4 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9595:MAPK1IP1L ^@ http://purl.uniprot.org/uniprot/A0A2I2Y506 ^@ Similarity ^@ Belongs to the MISS family. http://togogenome.org/gene/9595:LOC101138925 ^@ http://purl.uniprot.org/uniprot/G3QZ29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:KCNAB1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z0Y2|||http://purl.uniprot.org/uniprot/G3QX04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shaker potassium channel beta subunit family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9595:SEMA4F ^@ http://purl.uniprot.org/uniprot/A0A2I2ZT63|||http://purl.uniprot.org/uniprot/G3RBD9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:NEXMIF ^@ http://purl.uniprot.org/uniprot/G3QRF1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:AP2M1 ^@ http://purl.uniprot.org/uniprot/G3QWW1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cell membrane|||Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.|||coated pit http://togogenome.org/gene/9595:KLC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z2G1|||http://purl.uniprot.org/uniprot/A0A2I2Z5J7|||http://purl.uniprot.org/uniprot/A0A2I2ZL18 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kinesin light chain family.|||Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.|||Oligomeric complex composed of two heavy chains and two light chains.|||cytoskeleton http://togogenome.org/gene/9595:COQ8B ^@ http://purl.uniprot.org/uniprot/G3QQJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family.|||Membrane http://togogenome.org/gene/9595:SERPINB2 ^@ http://purl.uniprot.org/uniprot/G3SJ51 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9595:C16H16orf87 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y569|||http://purl.uniprot.org/uniprot/A0A2I2ZFU9 ^@ Similarity ^@ Belongs to the UPF0547 family. http://togogenome.org/gene/9595:AP1M2 ^@ http://purl.uniprot.org/uniprot/G3QPN0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Golgi apparatus|||Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9595:AUP1 ^@ http://purl.uniprot.org/uniprot/G3RV77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AUP1 family.|||Membrane http://togogenome.org/gene/9595:CLDN4 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZD15 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9595:SMAGP ^@ http://purl.uniprot.org/uniprot/G3QVA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMAGP family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/9595:SLX4 ^@ http://purl.uniprot.org/uniprot/G3RKC9 ^@ Similarity ^@ Belongs to the SLX4 family. http://togogenome.org/gene/9595:KCNG1 ^@ http://purl.uniprot.org/uniprot/G3QEX6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:ADISSP ^@ http://purl.uniprot.org/uniprot/G3RLD5 ^@ Similarity ^@ Belongs to the ADISSP family. http://togogenome.org/gene/9595:MRPL18 ^@ http://purl.uniprot.org/uniprot/G3RDW2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL18 family. http://togogenome.org/gene/9595:TIMM17B ^@ http://purl.uniprot.org/uniprot/G3R716 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9595:MARVELD3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YCW7|||http://purl.uniprot.org/uniprot/G3R0G0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:TAF4B ^@ http://purl.uniprot.org/uniprot/G3QN01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF4 family.|||Nucleus http://togogenome.org/gene/9595:RPE65 ^@ http://purl.uniprot.org/uniprot/G3R2K3 ^@ Cofactor|||Similarity ^@ Belongs to the carotenoid oxygenase family.|||Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/9595:GNA13 ^@ http://purl.uniprot.org/uniprot/G3R3I9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-alpha family. G(12) subfamily.|||Membrane http://togogenome.org/gene/9595:SEC23A ^@ http://purl.uniprot.org/uniprot/G3QFP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9595:CBLIF ^@ http://purl.uniprot.org/uniprot/G3QYP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic cobalamin transport proteins family.|||Secreted http://togogenome.org/gene/9595:S100G ^@ http://purl.uniprot.org/uniprot/A0A2I2ZVR9 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9595:CENPU ^@ http://purl.uniprot.org/uniprot/G3SGZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-U/AME1 family.|||Nucleus http://togogenome.org/gene/9595:TMEM91 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZY29 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9595:RBM48 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y675 ^@ Function|||Similarity|||Subunit ^@ As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.|||Belongs to the RBM48 family.|||Component of the minor spliceosome. Within this complex, interacts with ARMC7 and PRPF8/PRP8. http://togogenome.org/gene/9595:MAPK9 ^@ http://purl.uniprot.org/uniprot/A0A2I2YL40|||http://purl.uniprot.org/uniprot/G3S624 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/9595:C19H19orf53 ^@ http://purl.uniprot.org/uniprot/G3RW91 ^@ Function|||Similarity ^@ Belongs to the UPF0390 family.|||May have a potential role in hypercalcemia of malignancy. http://togogenome.org/gene/9595:DENND11 ^@ http://purl.uniprot.org/uniprot/G3S350 ^@ Similarity ^@ Belongs to the DENND11 family. http://togogenome.org/gene/9595:LOC101133676 ^@ http://purl.uniprot.org/uniprot/G3RKL7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:PDCL3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YTV8 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9595:ACOT4 ^@ http://purl.uniprot.org/uniprot/G3QGT1 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/9595:ZNF330 ^@ http://purl.uniprot.org/uniprot/G3QTD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOA36 family.|||centromere|||nucleolus http://togogenome.org/gene/9595:AGAP1 ^@ http://purl.uniprot.org/uniprot/G3QRY4 ^@ Similarity ^@ Belongs to the centaurin gamma-like family. http://togogenome.org/gene/9595:GPR107 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZIG7|||http://purl.uniprot.org/uniprot/A0A2I2ZY99 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:A4GALT ^@ http://purl.uniprot.org/uniprot/G3R1Q4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 32 family.|||Golgi apparatus membrane http://togogenome.org/gene/9595:SORCS2 ^@ http://purl.uniprot.org/uniprot/G3RID4 ^@ Similarity ^@ Belongs to the VPS10-related sortilin family. SORCS subfamily. http://togogenome.org/gene/9595:CLIC2 ^@ http://purl.uniprot.org/uniprot/G3S4N2 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/9595:THTPA ^@ http://purl.uniprot.org/uniprot/G3RFP6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ThTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Hydrolase highly specific for thiamine triphosphate (ThTP).|||Monomer. http://togogenome.org/gene/9595:ST7 ^@ http://purl.uniprot.org/uniprot/A0A2I2YR23|||http://purl.uniprot.org/uniprot/A0A2I2ZW51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ST7 family.|||Membrane http://togogenome.org/gene/9595:FMO1 ^@ http://purl.uniprot.org/uniprot/G3R5S9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:RNF111 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZY67|||http://purl.uniprot.org/uniprot/G3RLF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Arkadia family.|||PML body http://togogenome.org/gene/9595:SLC39A9 ^@ http://purl.uniprot.org/uniprot/A0A2I2YAB4|||http://purl.uniprot.org/uniprot/G3QQ00 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Cell membrane|||Membrane|||Mitochondrion|||Nucleus|||Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process.|||perinuclear region|||trans-Golgi network membrane http://togogenome.org/gene/9595:OLFML1 ^@ http://purl.uniprot.org/uniprot/G3RFU2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:NOTCH4 ^@ http://purl.uniprot.org/uniprot/G3QIT2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOTCH family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Nucleus http://togogenome.org/gene/9595:POU2F1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YMW8|||http://purl.uniprot.org/uniprot/G3RJF8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-2 subfamily.|||Nucleus|||Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. http://togogenome.org/gene/9595:FITM2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y8H2 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:LOC101152773 ^@ http://purl.uniprot.org/uniprot/G3S254 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative pheromone receptor. http://togogenome.org/gene/9595:RND3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YTX1 ^@ Function ^@ Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. http://togogenome.org/gene/9595:LOC109024612 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y4J7 ^@ Similarity ^@ Belongs to the MIF family. http://togogenome.org/gene/9595:POP7 ^@ http://purl.uniprot.org/uniprot/G3RK28 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone-like Alba family.|||Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA.|||Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.|||Cytoplasmic granule|||nucleolus http://togogenome.org/gene/9595:LOC101153670 ^@ http://purl.uniprot.org/uniprot/Q7YRP1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Putative pheromone receptor. http://togogenome.org/gene/9595:SERPINB13 ^@ http://purl.uniprot.org/uniprot/G3RH08 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9595:ASB10 ^@ http://purl.uniprot.org/uniprot/G3QDI7 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9595:DOK6 ^@ http://purl.uniprot.org/uniprot/G3QLB4 ^@ Similarity ^@ Belongs to the DOK family. Type B subfamily. http://togogenome.org/gene/9595:SLC16A9 ^@ http://purl.uniprot.org/uniprot/G3QNE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:C22H22orf39 ^@ http://purl.uniprot.org/uniprot/A0A2I2YAN1|||http://purl.uniprot.org/uniprot/G3QNB3 ^@ Similarity ^@ Belongs to the UPF0545 family. http://togogenome.org/gene/9595:FES ^@ http://purl.uniprot.org/uniprot/A0A2I2Y925|||http://purl.uniprot.org/uniprot/G3QYQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.|||Cell membrane|||Membrane|||cytoskeleton http://togogenome.org/gene/9595:FUT10 ^@ http://purl.uniprot.org/uniprot/G3RYS5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Membrane|||Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. http://togogenome.org/gene/9595:XKR7 ^@ http://purl.uniprot.org/uniprot/G3QR93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9595:SEMA4C ^@ http://purl.uniprot.org/uniprot/G3RF86 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:TOR1B ^@ http://purl.uniprot.org/uniprot/G3RC05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ClpA/ClpB family. Torsin subfamily.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9595:ADGRF4 ^@ http://purl.uniprot.org/uniprot/G3S419 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:SERPINH1 ^@ http://purl.uniprot.org/uniprot/G3QRM5 ^@ Function|||Similarity ^@ Belongs to the serpin family.|||Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. http://togogenome.org/gene/9595:TPD52 ^@ http://purl.uniprot.org/uniprot/A0A2I2YVH2|||http://purl.uniprot.org/uniprot/A0A2I2YZK1|||http://purl.uniprot.org/uniprot/A0A2I2ZCD5|||http://purl.uniprot.org/uniprot/A0A2I2ZN07 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/9595:NCDN ^@ http://purl.uniprot.org/uniprot/G3R2R9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the neurochondrin family.|||Postsynapse http://togogenome.org/gene/9595:DGKB ^@ http://purl.uniprot.org/uniprot/G3RD41 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/9595:DDX59 ^@ http://purl.uniprot.org/uniprot/G3RF94 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX59 subfamily. http://togogenome.org/gene/9595:LOC101142073 ^@ http://purl.uniprot.org/uniprot/G3RI59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:LOC101151014 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZKF5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:TADA1 ^@ http://purl.uniprot.org/uniprot/G3QYP6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TADA1 family.|||Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.|||Nucleus|||Probably involved in transcriptional regulation. http://togogenome.org/gene/9595:TSSK6 ^@ http://purl.uniprot.org/uniprot/A0A2I2YMX2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:UBE4B ^@ http://purl.uniprot.org/uniprot/A0A2I2YLT5|||http://purl.uniprot.org/uniprot/G3SJP0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin conjugation factor E4 family.|||Cytoplasm|||The U-box domain is required for the ubiquitin protein ligase activity.|||Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. http://togogenome.org/gene/9595:MAPK13 ^@ http://purl.uniprot.org/uniprot/G3QMX6 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Interacts with MAPK8IP2. http://togogenome.org/gene/9595:CCNA1 ^@ http://purl.uniprot.org/uniprot/G3SD32 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin AB subfamily. http://togogenome.org/gene/9595:HYAL3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1W2|||http://purl.uniprot.org/uniprot/G3QVY8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 56 family.|||Cell membrane|||Early endosome|||Endoplasmic reticulum|||Endosome|||Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage.|||Membrane|||acrosome http://togogenome.org/gene/9595:CBFB ^@ http://purl.uniprot.org/uniprot/A0A2I2ZPC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CBF-beta family.|||Nucleus http://togogenome.org/gene/9595:SCTR ^@ http://purl.uniprot.org/uniprot/G3SA07 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:PDYN ^@ http://purl.uniprot.org/uniprot/G3QNZ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the opioid neuropeptide precursor family.|||Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin.|||Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.|||Leumorphin has a typical opioid activity and may have anti-apoptotic effect.|||Secreted http://togogenome.org/gene/9595:CNOT2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YKY8|||http://purl.uniprot.org/uniprot/A0A2I2YMV9 ^@ Similarity ^@ Belongs to the CNOT2/3/5 family. http://togogenome.org/gene/9595:SH3RF2 ^@ http://purl.uniprot.org/uniprot/G3QYX0 ^@ Similarity ^@ Belongs to the SH3RF family. http://togogenome.org/gene/9595:GSC ^@ http://purl.uniprot.org/uniprot/A1YEY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus|||Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity). Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals (By similarity). http://togogenome.org/gene/9595:PHACTR3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YCF8 ^@ Similarity|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin. http://togogenome.org/gene/9595:SMAD4 ^@ http://purl.uniprot.org/uniprot/G3RCU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:CDT1 ^@ http://purl.uniprot.org/uniprot/G3SII6 ^@ Similarity ^@ Belongs to the Cdt1 family. http://togogenome.org/gene/9595:NRDE2 ^@ http://purl.uniprot.org/uniprot/G3R0F7 ^@ Similarity ^@ Belongs to the NRDE2 family. http://togogenome.org/gene/9595:NDRG1 ^@ http://purl.uniprot.org/uniprot/G3RGT6 ^@ Similarity ^@ Belongs to the NDRG family. http://togogenome.org/gene/9595:KCNK2 ^@ http://purl.uniprot.org/uniprot/G3S7X7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9595:ADGRB3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZXA9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:CXCR3 ^@ http://purl.uniprot.org/uniprot/G3SIC0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Homomer. Forms heteromers with ACKR4.|||Membrane http://togogenome.org/gene/9595:CDC45 ^@ http://purl.uniprot.org/uniprot/G3QNC9|||http://purl.uniprot.org/uniprot/G3S0K0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC45 family.|||Nucleus http://togogenome.org/gene/9595:IP6K2 ^@ http://purl.uniprot.org/uniprot/G3S2C6 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9595:LOC109028938 ^@ http://purl.uniprot.org/uniprot/G3RV74 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:VSX1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZMR4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:LOC101143171 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZBD5 ^@ Similarity ^@ Belongs to the COX20 family. http://togogenome.org/gene/9595:INSRR ^@ http://purl.uniprot.org/uniprot/G3RD72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Membrane http://togogenome.org/gene/9595:ATG5 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZSN8|||http://purl.uniprot.org/uniprot/G3RKG2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG5 family.|||Conjugated with ATG12.|||Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.|||May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.|||Preautophagosomal structure membrane http://togogenome.org/gene/9595:DCSTAMP ^@ http://purl.uniprot.org/uniprot/G3QHW0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:STK10 ^@ http://purl.uniprot.org/uniprot/G3R9P8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Cell membrane http://togogenome.org/gene/9595:QPCTL ^@ http://purl.uniprot.org/uniprot/G3RR07 ^@ Similarity ^@ Belongs to the glutaminyl-peptide cyclotransferase family. http://togogenome.org/gene/9595:KCNJ11 ^@ http://purl.uniprot.org/uniprot/G3QMA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.|||Membrane http://togogenome.org/gene/9595:LOC101151489 ^@ http://purl.uniprot.org/uniprot/G3RM83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:SEMA3A ^@ http://purl.uniprot.org/uniprot/G3RGH7 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:NKX2-6 ^@ http://purl.uniprot.org/uniprot/G3REM7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:EXOSC2 ^@ http://purl.uniprot.org/uniprot/G3R4V1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP4 family.|||Cytoplasm http://togogenome.org/gene/9595:OOEP ^@ http://purl.uniprot.org/uniprot/G3RKY9 ^@ Similarity ^@ Belongs to the KHDC1 family. http://togogenome.org/gene/9595:ACTG2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YVV7 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9595:GPCPD1 ^@ http://purl.uniprot.org/uniprot/G3R799 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9595:SERPINB7 ^@ http://purl.uniprot.org/uniprot/G3R4Q2 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9595:LOC101141197 ^@ http://purl.uniprot.org/uniprot/G3QW96 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:TET3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZVI3|||http://purl.uniprot.org/uniprot/G3R9M3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TET family.|||Binds 1 Fe(2+) ion per subunit.|||Chromosome|||Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.|||The zinc ions have a structural role. http://togogenome.org/gene/9595:LIMS2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZTS6|||http://purl.uniprot.org/uniprot/G3QPZ6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.|||Cell membrane|||Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.|||focal adhesion http://togogenome.org/gene/9595:PIAS1 ^@ http://purl.uniprot.org/uniprot/G3SEZ4 ^@ Similarity ^@ Belongs to the PIAS family. http://togogenome.org/gene/9595:ADCY8 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZTJ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/9595:GABBR1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z6U7|||http://purl.uniprot.org/uniprot/G3S7N5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:TFCP2L1 ^@ http://purl.uniprot.org/uniprot/G3RZF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus http://togogenome.org/gene/9595:CNTNAP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YT94 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||paranodal septate junction http://togogenome.org/gene/9595:PSMD13 ^@ http://purl.uniprot.org/uniprot/G3RBH4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S11 family.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. http://togogenome.org/gene/9595:LOC101141204 ^@ http://purl.uniprot.org/uniprot/G3QMM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:SLC25A16 ^@ http://purl.uniprot.org/uniprot/G3SAL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9595:LOC101127921 ^@ http://purl.uniprot.org/uniprot/G3QL15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ZAR1L ^@ http://purl.uniprot.org/uniprot/G3RIB7 ^@ Similarity|||Subunit ^@ Belongs to the ZAR1 family.|||Interacts with YBX2. http://togogenome.org/gene/9595:ORMDL3 ^@ http://purl.uniprot.org/uniprot/G3QZ09 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/9595:MAGOH ^@ http://purl.uniprot.org/uniprot/G3QX92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mago nashi family.|||Nucleus http://togogenome.org/gene/9595:NELFE ^@ http://purl.uniprot.org/uniprot/G3QIL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM NELF-E family.|||Chromosome|||Nucleus http://togogenome.org/gene/9595:SLC20A2 ^@ http://purl.uniprot.org/uniprot/G3RFR5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter. http://togogenome.org/gene/9595:HOXA7 ^@ http://purl.uniprot.org/uniprot/G3QIH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9595:LSM12 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y1P3 ^@ Similarity ^@ Belongs to the LSM12 family. http://togogenome.org/gene/9595:ME3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZR73 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/9595:PSKH1 ^@ http://purl.uniprot.org/uniprot/G3RDE0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:CRYAB ^@ http://purl.uniprot.org/uniprot/G3QR27 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.|||Nucleus http://togogenome.org/gene/9595:GSDMA ^@ http://purl.uniprot.org/uniprot/G3QQR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gasdermin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:AGRP ^@ http://purl.uniprot.org/uniprot/G3RB26 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9595:KDM5C ^@ http://purl.uniprot.org/uniprot/G3QXH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JARID1 histone demethylase family.|||Nucleus http://togogenome.org/gene/9595:SLC66A3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z450|||http://purl.uniprot.org/uniprot/G3QGR7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:HSPA4 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y3A1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 70 family.|||Cytoplasm|||Interacts with TJP1/ZO-1. http://togogenome.org/gene/9595:FAM118B ^@ http://purl.uniprot.org/uniprot/G3RK42 ^@ Similarity ^@ Belongs to the FAM118 family. http://togogenome.org/gene/9595:MAB21L2 ^@ http://purl.uniprot.org/uniprot/G3RDX9 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9595:SEPTIN5 ^@ http://purl.uniprot.org/uniprot/G3S5Y8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9595:TAF15 ^@ http://purl.uniprot.org/uniprot/G3SB91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TET family.|||Nucleus http://togogenome.org/gene/9595:PEX13 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1K5 ^@ Similarity ^@ Belongs to the peroxin-13 family. http://togogenome.org/gene/9595:CD247 ^@ http://purl.uniprot.org/uniprot/G3RQW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD3Z/FCER1G family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ITGB4 ^@ http://purl.uniprot.org/uniprot/G3S7A9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:GAPDHS ^@ http://purl.uniprot.org/uniprot/A0A2I2ZPL6|||http://purl.uniprot.org/uniprot/G3QD23 ^@ Similarity|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/9595:LOC101148972 ^@ http://purl.uniprot.org/uniprot/G3RMA0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9595:CDC42SE1 ^@ http://purl.uniprot.org/uniprot/G3QYT6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CDC42SE/SPEC family.|||Cell membrane|||Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.|||Membrane|||Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.|||cytoskeleton http://togogenome.org/gene/9595:MYMK ^@ http://purl.uniprot.org/uniprot/G3RFK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:PLCG2 ^@ http://purl.uniprot.org/uniprot/G3SIE4 ^@ Function ^@ Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. http://togogenome.org/gene/9595:CKMT2 ^@ http://purl.uniprot.org/uniprot/G3QT01 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/9595:RPGRIP1L ^@ http://purl.uniprot.org/uniprot/G3RSN7 ^@ Similarity ^@ Belongs to the RPGRIP1 family. http://togogenome.org/gene/9595:SLC22A2 ^@ http://purl.uniprot.org/uniprot/G3RCS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.|||Cell membrane http://togogenome.org/gene/9595:RFFL ^@ http://purl.uniprot.org/uniprot/G3QNH3 ^@ Subcellular Location Annotation ^@ Cell membrane|||cytosol http://togogenome.org/gene/9595:LOC101129483 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZNI8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:GPR50 ^@ http://purl.uniprot.org/uniprot/G3RAM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:UCP2 ^@ http://purl.uniprot.org/uniprot/G3QMN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9595:SENP1 ^@ http://purl.uniprot.org/uniprot/G3SH09 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/9595:POU2F3 ^@ http://purl.uniprot.org/uniprot/G3R046 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-2 subfamily.|||Nucleus http://togogenome.org/gene/9595:TBX22 ^@ http://purl.uniprot.org/uniprot/G3R0U6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9595:MSH6 ^@ http://purl.uniprot.org/uniprot/G3RSZ9 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||Component of the post-replicative DNA mismatch repair system (MMR). http://togogenome.org/gene/9595:HMGN1 ^@ http://purl.uniprot.org/uniprot/G3RCV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/9595:SI ^@ http://purl.uniprot.org/uniprot/G3SAD6 ^@ Caution|||Similarity ^@ Belongs to the glycosyl hydrolase 31 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:MBD4 ^@ http://purl.uniprot.org/uniprot/G3S7S7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with MLH1.|||Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.|||Nucleus http://togogenome.org/gene/9595:UXS1 ^@ http://purl.uniprot.org/uniprot/G3SKK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9595:SLC12A3 ^@ http://purl.uniprot.org/uniprot/G3R3N4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9595:ING1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z748|||http://purl.uniprot.org/uniprot/G3R714|||http://purl.uniprot.org/uniprot/G3RB52 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9595:PIK3CG ^@ http://purl.uniprot.org/uniprot/G3S7D1 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9595:NCOA7 ^@ http://purl.uniprot.org/uniprot/G3S9J5 ^@ Similarity ^@ Belongs to the OXR1 family. http://togogenome.org/gene/9595:NAA35 ^@ http://purl.uniprot.org/uniprot/G3R7B4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.|||Belongs to the MAK10 family.|||Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.|||Cytoplasm http://togogenome.org/gene/9595:PHACTR4 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y9Y9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin.|||Cytoplasm|||Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway.|||lamellipodium http://togogenome.org/gene/9595:NAGK ^@ http://purl.uniprot.org/uniprot/G3RVS8 ^@ Similarity ^@ Belongs to the eukaryotic-type N-acetylglucosamine kinase family. http://togogenome.org/gene/9595:SLC5A2 ^@ http://purl.uniprot.org/uniprot/G3QP83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:AGPAT5 ^@ http://purl.uniprot.org/uniprot/G3S173 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9595:SEC61A2 ^@ http://purl.uniprot.org/uniprot/G3R0J3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:NEUROD2 ^@ http://purl.uniprot.org/uniprot/G3SDZ7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:CLDN10 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y969|||http://purl.uniprot.org/uniprot/G3SE82 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9595:CNIH2 ^@ http://purl.uniprot.org/uniprot/G3R2S2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/9595:PNLIPRP3 ^@ http://purl.uniprot.org/uniprot/G3RQH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9595:TGFBR2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z3A0|||http://purl.uniprot.org/uniprot/G3RL67 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Cell membrane|||Membrane|||Membrane raft|||Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. http://togogenome.org/gene/9595:ARRDC2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YLQ2|||http://purl.uniprot.org/uniprot/G3QSN6 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9595:SDR16C5 ^@ http://purl.uniprot.org/uniprot/G3QN45 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9595:PEDS1 ^@ http://purl.uniprot.org/uniprot/G3SK25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase CarF family.|||Membrane http://togogenome.org/gene/9595:SSTR1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YYN4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:PNLIP ^@ http://purl.uniprot.org/uniprot/G3RIW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9595:GTF2F2 ^@ http://purl.uniprot.org/uniprot/G3QUV7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIF beta subunit family.|||Nucleus|||TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. http://togogenome.org/gene/9595:HSPB1 ^@ http://purl.uniprot.org/uniprot/G3QJQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Nucleus|||spindle http://togogenome.org/gene/9595:IL6 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZVU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-6 superfamily.|||Secreted http://togogenome.org/gene/9595:STMN3 ^@ http://purl.uniprot.org/uniprot/G3QQ21 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/9595:TPT1 ^@ http://purl.uniprot.org/uniprot/G3RPB3 ^@ Similarity ^@ Belongs to the TCTP family. http://togogenome.org/gene/9595:NIBAN3 ^@ http://purl.uniprot.org/uniprot/G3R801|||http://purl.uniprot.org/uniprot/G3RZK1 ^@ Similarity ^@ Belongs to the Niban family. http://togogenome.org/gene/9595:LOC101133653 ^@ http://purl.uniprot.org/uniprot/G3S3T1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:SDC2 ^@ http://purl.uniprot.org/uniprot/G3R6Y9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane http://togogenome.org/gene/9595:DTNBP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YMU0 ^@ Similarity ^@ Belongs to the dysbindin family. http://togogenome.org/gene/9595:PPP2R2C ^@ http://purl.uniprot.org/uniprot/A0A2I2ZV54|||http://purl.uniprot.org/uniprot/G3QLS1 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/9595:PTGDR ^@ http://purl.uniprot.org/uniprot/G3R4K5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:CRY2 ^@ http://purl.uniprot.org/uniprot/G3QIP3 ^@ Cofactor|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/9595:GNRHR ^@ http://purl.uniprot.org/uniprot/G3RJ87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:CDH1 ^@ http://purl.uniprot.org/uniprot/G3QT90 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:NCF2 ^@ http://purl.uniprot.org/uniprot/G3QFC9 ^@ Similarity ^@ Belongs to the NCF2/NOXA1 family. http://togogenome.org/gene/9595:NME3 ^@ http://purl.uniprot.org/uniprot/G3QTR3 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9595:SRD5A2 ^@ http://purl.uniprot.org/uniprot/G3RPI7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.|||Membrane|||Microsome membrane http://togogenome.org/gene/9595:ETS2 ^@ http://purl.uniprot.org/uniprot/G3RHG5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus|||Transcription factor. http://togogenome.org/gene/9595:ELF2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YZF6|||http://purl.uniprot.org/uniprot/G3RIQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9595:ADAM30 ^@ http://purl.uniprot.org/uniprot/G3QN27 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:PGBD1 ^@ http://purl.uniprot.org/uniprot/G3QHA8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9595:TEKT1 ^@ http://purl.uniprot.org/uniprot/G3RGY1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/9595:MAP2K4 ^@ http://purl.uniprot.org/uniprot/A0A2I2YYX3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:FAM90A1 ^@ http://purl.uniprot.org/uniprot/G3RBI7 ^@ Similarity ^@ Belongs to the FAM90 family. http://togogenome.org/gene/9595:MTMR10 ^@ http://purl.uniprot.org/uniprot/G3QHT1 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9595:SNRPD3 ^@ http://purl.uniprot.org/uniprot/G3RHX9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.|||cytosol http://togogenome.org/gene/9595:LOC101128940 ^@ http://purl.uniprot.org/uniprot/G3QJA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:LOC101154164 ^@ http://purl.uniprot.org/uniprot/G3SAR3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:NAPA ^@ http://purl.uniprot.org/uniprot/G3RUI1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/9595:RPS2 ^@ http://purl.uniprot.org/uniprot/G3R1S4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS5 family. http://togogenome.org/gene/9595:CA4 ^@ http://purl.uniprot.org/uniprot/G3R792 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9595:ATP2C1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZCG7|||http://purl.uniprot.org/uniprot/G3S1X4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:KARS1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZRC2|||http://purl.uniprot.org/uniprot/G3QRY3 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9595:GNPDA1 ^@ http://purl.uniprot.org/uniprot/G3R0S4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/9595:LYPD5 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZQ19 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:BEX4 ^@ http://purl.uniprot.org/uniprot/A0A2I2YSJ6 ^@ Similarity ^@ Belongs to the BEX family. http://togogenome.org/gene/9595:QKI ^@ http://purl.uniprot.org/uniprot/G3QEM5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9595:KCNE4 ^@ http://purl.uniprot.org/uniprot/G3RLT2 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/9595:C11H11orf87 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y2H1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:ASPM ^@ http://purl.uniprot.org/uniprot/G3S2N2|||http://purl.uniprot.org/uniprot/P62289 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Nucleus|||Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).|||spindle http://togogenome.org/gene/9595:GPNMB ^@ http://purl.uniprot.org/uniprot/G3RNQ2 ^@ Similarity ^@ Belongs to the PMEL/NMB family. http://togogenome.org/gene/9595:KRT76 ^@ http://purl.uniprot.org/uniprot/G3R730 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:CASP2 ^@ http://purl.uniprot.org/uniprot/G3QLZ6 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9595:TATDN1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZH97|||http://purl.uniprot.org/uniprot/G3S4C4 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. http://togogenome.org/gene/9595:MRGPRX2 ^@ http://purl.uniprot.org/uniprot/Q4QXU0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Mas subfamily.|||Cell membrane|||Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction. http://togogenome.org/gene/9595:PHC1 ^@ http://purl.uniprot.org/uniprot/G3RWP3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:CFAP299 ^@ http://purl.uniprot.org/uniprot/A0A2I2YHQ8 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in spermatogenesis.|||Nucleus http://togogenome.org/gene/9595:PRRC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z4B8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRRC1 family.|||Golgi apparatus http://togogenome.org/gene/9595:RNF20 ^@ http://purl.uniprot.org/uniprot/G3QN72 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BRE1 family.|||Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.|||Nucleus http://togogenome.org/gene/9595:EIF4E ^@ http://purl.uniprot.org/uniprot/A0A2I2YJ03 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/9595:CCL16 ^@ http://purl.uniprot.org/uniprot/A0A2I2YNA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9595:RPS9 ^@ http://purl.uniprot.org/uniprot/G3S5K1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/9595:SLITRK6 ^@ http://purl.uniprot.org/uniprot/G3SHZ6 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9595:WDR48 ^@ http://purl.uniprot.org/uniprot/G3QIE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR48 family.|||Late endosome http://togogenome.org/gene/9595:FLOT2 ^@ http://purl.uniprot.org/uniprot/G3S498|||http://purl.uniprot.org/uniprot/G3SC78 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily.|||Cell membrane|||Endosome|||Heterooligomeric complex.|||Membrane|||caveola http://togogenome.org/gene/9595:DCTN1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YZT7|||http://purl.uniprot.org/uniprot/G3RAK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin 150 kDa subunit family.|||cell cortex|||cytoskeleton http://togogenome.org/gene/9595:SFMBT1 ^@ http://purl.uniprot.org/uniprot/G3QSK5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:EXOG ^@ http://purl.uniprot.org/uniprot/A0A2I2YI25 ^@ Similarity ^@ Belongs to the DNA/RNA non-specific endonuclease family. http://togogenome.org/gene/9595:GPAT3 ^@ http://purl.uniprot.org/uniprot/G3QNL4 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9595:SLC22A18 ^@ http://purl.uniprot.org/uniprot/G3QYX3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:KCNH4 ^@ http://purl.uniprot.org/uniprot/G3RHR1 ^@ Subcellular Location Annotation|||Subunit ^@ Membrane|||The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. http://togogenome.org/gene/9595:MAP3K11 ^@ http://purl.uniprot.org/uniprot/G3R7Y7 ^@ Activity Regulation|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Homodimer.|||Homodimerization via the leucine zipper domains is required for autophosphorylation. http://togogenome.org/gene/9595:GDF15 ^@ http://purl.uniprot.org/uniprot/G3RL77 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9595:LPL ^@ http://purl.uniprot.org/uniprot/G3RHE2 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Cell membrane|||Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.|||Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted|||Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.|||extracellular matrix http://togogenome.org/gene/9595:MKS1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YI77|||http://purl.uniprot.org/uniprot/G3QKV3 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/9595:HTR1A ^@ http://purl.uniprot.org/uniprot/Q9N297 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.|||Cell membrane|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli (By similarity).|||Heterodimer; heterodimerizes with GPER1 (By similarity). Interacts with YIF1B (By similarity).|||dendrite http://togogenome.org/gene/9595:ASL ^@ http://purl.uniprot.org/uniprot/A0A2I2YTY7 ^@ Similarity ^@ Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. http://togogenome.org/gene/9595:MYH10 ^@ http://purl.uniprot.org/uniprot/G3SAH0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9595:RNASEH1 ^@ http://purl.uniprot.org/uniprot/G3SKF3 ^@ Function|||Similarity ^@ Belongs to the RNase H family.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. http://togogenome.org/gene/9595:HHIP ^@ http://purl.uniprot.org/uniprot/G3RC18 ^@ Caution|||Similarity ^@ Belongs to the HHIP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:SLC25A31 ^@ http://purl.uniprot.org/uniprot/G3RDN9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/9595:VKORC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y361|||http://purl.uniprot.org/uniprot/A0A2I2Z5N5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VKOR family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:CNTF ^@ http://purl.uniprot.org/uniprot/G3S3R9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNTF family.|||CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.|||Cytoplasm http://togogenome.org/gene/9595:PI4KB ^@ http://purl.uniprot.org/uniprot/G3RGN7 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9595:A1CF ^@ http://purl.uniprot.org/uniprot/G3R2J3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:IRX6 ^@ http://purl.uniprot.org/uniprot/G3SBL6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:DEFB134 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z0N5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9595:UPP2 ^@ http://purl.uniprot.org/uniprot/G3SF17 ^@ Similarity ^@ Belongs to the PNP/UDP phosphorylase family. http://togogenome.org/gene/9595:IGF1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YEV2|||http://purl.uniprot.org/uniprot/A0A2I2Z8G5|||http://purl.uniprot.org/uniprot/A0A2I2ZCP6|||http://purl.uniprot.org/uniprot/G3QQH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/9595:NIP7 ^@ http://purl.uniprot.org/uniprot/G3RX93 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NIP7 family.|||Interacts with pre-ribosome complex.|||Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.|||nucleolus http://togogenome.org/gene/9595:TOB1 ^@ http://purl.uniprot.org/uniprot/G3SFP3 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9595:RPL3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y8T8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/9595:SAG ^@ http://purl.uniprot.org/uniprot/G3R7T0 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9595:CKS1B ^@ http://purl.uniprot.org/uniprot/G3RC66 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.|||Forms a homohexamer that can probably bind six kinase subunits. http://togogenome.org/gene/9595:TINAG ^@ http://purl.uniprot.org/uniprot/G3QIW0 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/9595:PIM2 ^@ http://purl.uniprot.org/uniprot/G3R726 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.|||Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. http://togogenome.org/gene/9595:LOC101152878 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZL90|||http://purl.uniprot.org/uniprot/G3QEF9|||http://purl.uniprot.org/uniprot/G3QVV6|||http://purl.uniprot.org/uniprot/G3QYW5|||http://purl.uniprot.org/uniprot/G3S177|||http://purl.uniprot.org/uniprot/G3SIP1 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. http://togogenome.org/gene/9595:MINDY4 ^@ http://purl.uniprot.org/uniprot/G3RSH1 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM188 subfamily.|||Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. http://togogenome.org/gene/9595:TNFRSF1B ^@ http://purl.uniprot.org/uniprot/G3QXP8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:ERCC3 ^@ http://purl.uniprot.org/uniprot/G3RGX4 ^@ Similarity ^@ Belongs to the helicase family. RAD25/XPB subfamily. http://togogenome.org/gene/9595:SUGT1 ^@ http://purl.uniprot.org/uniprot/G3QV95 ^@ Similarity ^@ Belongs to the SGT1 family. http://togogenome.org/gene/9595:EXOC6 ^@ http://purl.uniprot.org/uniprot/G3RRM3 ^@ Function|||Similarity ^@ Belongs to the SEC15 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/9595:PSMF1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZD11|||http://purl.uniprot.org/uniprot/G3RR56 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the proteasome inhibitor PI31 family.|||Cytoplasm|||Endoplasmic reticulum|||Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28. http://togogenome.org/gene/9595:DSG3 ^@ http://purl.uniprot.org/uniprot/G3QFR0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||desmosome http://togogenome.org/gene/9595:HYOU1 ^@ http://purl.uniprot.org/uniprot/G3QYC5 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9595:PSMA2 ^@ http://purl.uniprot.org/uniprot/G3QUJ3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9595:CCL20 ^@ http://purl.uniprot.org/uniprot/G3S3G7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9595:DR1 ^@ http://purl.uniprot.org/uniprot/G3SFJ8 ^@ Similarity ^@ Belongs to the NC2 beta/DR1 family. http://togogenome.org/gene/9595:TSPOAP1 ^@ http://purl.uniprot.org/uniprot/G3RKP4|||http://purl.uniprot.org/uniprot/G3S991 ^@ Similarity ^@ Belongs to the RIMBP family. http://togogenome.org/gene/9595:RPS13 ^@ http://purl.uniprot.org/uniprot/G3QWW5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/9595:TRMT44 ^@ http://purl.uniprot.org/uniprot/G3QYB3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.|||Belongs to the TRM44 family.|||Cytoplasm|||Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase. http://togogenome.org/gene/9595:WRNIP1 ^@ http://purl.uniprot.org/uniprot/G3RVZ9 ^@ Similarity ^@ Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily. http://togogenome.org/gene/9595:CNTNAP4 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y548 ^@ Caution|||Similarity ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:PIGL ^@ http://purl.uniprot.org/uniprot/A0A2I2ZCE4|||http://purl.uniprot.org/uniprot/G3QJW0 ^@ Function|||Similarity ^@ Belongs to the PIGL family.|||Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol. http://togogenome.org/gene/9595:PARL ^@ http://purl.uniprot.org/uniprot/A0A2I2ZND2|||http://purl.uniprot.org/uniprot/G3QDT3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:TSPYL4 ^@ http://purl.uniprot.org/uniprot/G3RWF3 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9595:CABS1 ^@ http://purl.uniprot.org/uniprot/G3QQX9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Membrane|||Mitochondrion inner membrane|||flagellum http://togogenome.org/gene/9595:ZNF445 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZW14 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:TCP11L1 ^@ http://purl.uniprot.org/uniprot/G3S9C9 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/9595:SLC44A2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YQW2|||http://purl.uniprot.org/uniprot/G3SEU4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/9595:HSDL1 ^@ http://purl.uniprot.org/uniprot/G3RIW2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9595:GABRA4 ^@ http://purl.uniprot.org/uniprot/G3RPF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9595:NHS ^@ http://purl.uniprot.org/uniprot/G3SA46 ^@ Similarity ^@ Belongs to the NHS family. http://togogenome.org/gene/9595:KYNU ^@ http://purl.uniprot.org/uniprot/G3RXV2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kynureninase family.|||Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/9595:CFB ^@ http://purl.uniprot.org/uniprot/Q864V9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S1 family.|||Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes (By similarity).|||Monomer (By similarity). Part of the C3-convertase enzyme complex comprised of Complement C3 beta chain (C3b) and Complement factor B Bb fragment (Bb) and CFP (By similarity). Interacts to C3b; this interaction is dependent on the presence of Mg2+ (By similarity). Interacts to CFP; this interaction contributes to the stabilization of the active C3-convertase enzyme complex (By similarity).|||Secreted|||The unliganded VWA domain has an inactive 'locked' conformation whereby the scissile Arg-259|Lys-260 bond is protected from proteolytic activation. http://togogenome.org/gene/9595:PDCD4 ^@ http://purl.uniprot.org/uniprot/G3S1V1 ^@ Similarity ^@ Belongs to the PDCD4 family. http://togogenome.org/gene/9595:VXN ^@ http://purl.uniprot.org/uniprot/G3QZK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vexin family.|||Cell membrane|||Membrane|||Nucleus http://togogenome.org/gene/9595:HPX ^@ http://purl.uniprot.org/uniprot/G3QMZ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the hemopexin family.|||Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.|||Secreted http://togogenome.org/gene/9595:NRG4 ^@ http://purl.uniprot.org/uniprot/G3SDI0 ^@ Caution|||Similarity ^@ Belongs to the neuregulin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:RSAD1 ^@ http://purl.uniprot.org/uniprot/G3QUI2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.|||May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen-III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Mitochondrion http://togogenome.org/gene/9595:DAZAP2 ^@ http://purl.uniprot.org/uniprot/G3RU69 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus speckle|||nuclear body http://togogenome.org/gene/9595:ZDHHC12 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZHI5 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9595:SLC35A1 ^@ http://purl.uniprot.org/uniprot/G3QT26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:METTL3 ^@ http://purl.uniprot.org/uniprot/G3QT25 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/9595:LZIC ^@ http://purl.uniprot.org/uniprot/G3RET6 ^@ Similarity ^@ Belongs to the CTNNBIP1 family. http://togogenome.org/gene/9595:CACTIN ^@ http://purl.uniprot.org/uniprot/G3R9X4 ^@ Similarity ^@ Belongs to the CACTIN family. http://togogenome.org/gene/9595:SELENBP1 ^@ http://purl.uniprot.org/uniprot/G3SB02 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the selenium-binding protein family.|||Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.|||Interacts with USP33.|||Membrane|||Nucleus|||cytosol http://togogenome.org/gene/9595:ZSCAN12 ^@ http://purl.uniprot.org/uniprot/A0A2I2YPJ7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:FARSA ^@ http://purl.uniprot.org/uniprot/G3QLK6 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily. http://togogenome.org/gene/9595:LOC109025096 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZG17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9595:BCL2A1 ^@ http://purl.uniprot.org/uniprot/G3QTD3 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9595:RRM1 ^@ http://purl.uniprot.org/uniprot/G3S601 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/9595:SLC25A46 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZSH1|||http://purl.uniprot.org/uniprot/G3RWU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9595:SBF2 ^@ http://purl.uniprot.org/uniprot/G3R071 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9595:FBLN5 ^@ http://purl.uniprot.org/uniprot/G3SEY7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:UBR4 ^@ http://purl.uniprot.org/uniprot/G3QCW4 ^@ Similarity ^@ Belongs to the UBR4 family. http://togogenome.org/gene/9595:CDX4 ^@ http://purl.uniprot.org/uniprot/G3QRT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Caudal homeobox family.|||Nucleus http://togogenome.org/gene/9595:ICAM1 ^@ http://purl.uniprot.org/uniprot/Q5NKV9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the immunoglobulin superfamily. ICAM family.|||Homodimer. Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Interacts (on T cell side) with CD81, CD247 and CD9 at immunological synapses between antigen-presenting cells and T cells.|||ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity).|||Membrane|||Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis. http://togogenome.org/gene/9595:ALK ^@ http://purl.uniprot.org/uniprot/G3QP17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Cell membrane http://togogenome.org/gene/9595:ZNF449 ^@ http://purl.uniprot.org/uniprot/A1YEQ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9595:MPPED2 ^@ http://purl.uniprot.org/uniprot/G3R4B9 ^@ Similarity ^@ Belongs to the UPF0046 family. http://togogenome.org/gene/9595:LOC101132889 ^@ http://purl.uniprot.org/uniprot/G3RCM8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/9595:C19H19orf25 ^@ http://purl.uniprot.org/uniprot/A0A2I2YEC3 ^@ Similarity ^@ Belongs to the UPF0449 family. http://togogenome.org/gene/9595:STK32A ^@ http://purl.uniprot.org/uniprot/A0A2I2YKE0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:STAT4 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z2W4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:MRPL40 ^@ http://purl.uniprot.org/uniprot/G3R9E9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL40 family.|||Mitochondrion http://togogenome.org/gene/9595:DDX28 ^@ http://purl.uniprot.org/uniprot/G3QFW9 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9595:SERPINB12 ^@ http://purl.uniprot.org/uniprot/G3RCV8 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9595:IL33 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z316 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family. Highly divergent.|||Chromosome|||Nucleus|||Secreted|||Vesicle|||secretory vesicle http://togogenome.org/gene/9595:ADGRG6 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZJJ8|||http://purl.uniprot.org/uniprot/G3QJJ6|||http://purl.uniprot.org/uniprot/G3SC49 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:TXK ^@ http://purl.uniprot.org/uniprot/G3R0X0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9595:SLF2 ^@ http://purl.uniprot.org/uniprot/G3RR25 ^@ Similarity ^@ Belongs to the FAM178 family. http://togogenome.org/gene/9595:RPN1 ^@ http://purl.uniprot.org/uniprot/G3RDM0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST1 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/9595:TMCO4 ^@ http://purl.uniprot.org/uniprot/G3QRD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMCO4 family.|||Membrane http://togogenome.org/gene/9595:LOC101125134 ^@ http://purl.uniprot.org/uniprot/G3SDT0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9595:SLC18A1 ^@ http://purl.uniprot.org/uniprot/G3QMR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Vesicular transporter family.|||Membrane|||secretory vesicle membrane|||synaptic vesicle membrane http://togogenome.org/gene/9595:DLST ^@ http://purl.uniprot.org/uniprot/G3R7H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Mitochondrion matrix http://togogenome.org/gene/9595:ITGB3BP ^@ http://purl.uniprot.org/uniprot/A0A2I2Y3V7 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Transcription coregulator that can have both coactivator and corepressor functions.|||centromere|||kinetochore http://togogenome.org/gene/9595:TERF2 ^@ http://purl.uniprot.org/uniprot/G3QP07 ^@ Subcellular Location Annotation ^@ Nucleus|||telomere http://togogenome.org/gene/9595:MOG ^@ http://purl.uniprot.org/uniprot/A0A2I2Z2U8|||http://purl.uniprot.org/uniprot/G3S9X6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Homodimer.|||Membrane|||Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion. http://togogenome.org/gene/9595:P2RX7 ^@ http://purl.uniprot.org/uniprot/G3RD86 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P2X receptor family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9595:PARVA ^@ http://purl.uniprot.org/uniprot/G3RFD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the parvin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ALDH1A2 ^@ http://purl.uniprot.org/uniprot/G3QXF4 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9595:TMCC3 ^@ http://purl.uniprot.org/uniprot/G3QX43 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/9595:SPSB2 ^@ http://purl.uniprot.org/uniprot/G3QJI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPSB family.|||Cytoplasm http://togogenome.org/gene/9595:PREP ^@ http://purl.uniprot.org/uniprot/G3RLW9 ^@ Similarity ^@ Belongs to the peptidase S9A family. http://togogenome.org/gene/9595:FAM124A ^@ http://purl.uniprot.org/uniprot/G3SK63 ^@ Similarity ^@ Belongs to the FAM124 family. http://togogenome.org/gene/9595:MND1 ^@ http://purl.uniprot.org/uniprot/G3S610 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MND1 family.|||Nucleus|||Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. http://togogenome.org/gene/9595:TM9SF4 ^@ http://purl.uniprot.org/uniprot/G3R4T4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/9595:BMP8A ^@ http://purl.uniprot.org/uniprot/G3RIA7 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9595:RPSA ^@ http://purl.uniprot.org/uniprot/G3RGD1 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.|||Belongs to the universal ribosomal protein uS2 family.|||Cell membrane|||Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.|||Cytoplasm|||Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.|||Nucleus|||Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.|||This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. http://togogenome.org/gene/9595:ZDHHC13 ^@ http://purl.uniprot.org/uniprot/G3QQ63 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9595:DUXA ^@ http://purl.uniprot.org/uniprot/G3QSA4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:PIGZ ^@ http://purl.uniprot.org/uniprot/G3QUW4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:CSGALNACT1 ^@ http://purl.uniprot.org/uniprot/G3R2I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9595:NCAPG ^@ http://purl.uniprot.org/uniprot/G3RGB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CND3 (condensin subunit 3) family.|||Chromosome http://togogenome.org/gene/9595:TMEM147 ^@ http://purl.uniprot.org/uniprot/G3QD24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM147 family.|||Cell membrane|||Endoplasmic reticulum membrane|||Membrane|||Nucleus membrane http://togogenome.org/gene/9595:ATIC ^@ http://purl.uniprot.org/uniprot/G3QY24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PurH family.|||cytosol http://togogenome.org/gene/9595:PLCB3 ^@ http://purl.uniprot.org/uniprot/G3R963 ^@ Cofactor|||Function ^@ Binds 1 Ca(2+) ion per subunit.|||The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. http://togogenome.org/gene/9595:FFAR1 ^@ http://purl.uniprot.org/uniprot/G3R154 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:STIM1 ^@ http://purl.uniprot.org/uniprot/G3RE38 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:DLX6 ^@ http://purl.uniprot.org/uniprot/G3S8M4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:PPP1R14A ^@ http://purl.uniprot.org/uniprot/G3QTH2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PP1 inhibitor family.|||Cytoplasm|||Inhibitor of PPP1CA. http://togogenome.org/gene/9595:APIP ^@ http://purl.uniprot.org/uniprot/G3RWT9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aldolase class II family. Adducin subfamily.|||Belongs to the aldolase class II family. MtnB subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.|||Cytoplasm|||Homotetramer. Interacts with APAF1. May interact with CASP1. http://togogenome.org/gene/9595:BTK ^@ http://purl.uniprot.org/uniprot/G3SKC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cytoplasm http://togogenome.org/gene/9595:MTX1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZE46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metaxin family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9595:CLCA2 ^@ http://purl.uniprot.org/uniprot/G3QME4 ^@ Similarity ^@ Belongs to the CLCR family. http://togogenome.org/gene/9595:JUP ^@ http://purl.uniprot.org/uniprot/G3R3M9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-catenin family.|||adherens junction http://togogenome.org/gene/9595:GSX1 ^@ http://purl.uniprot.org/uniprot/G3QQN4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:RBM46 ^@ http://purl.uniprot.org/uniprot/G3QHL5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:CSNK1A1L ^@ http://purl.uniprot.org/uniprot/A0A2I2YZI4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:TGIF2LX ^@ http://purl.uniprot.org/uniprot/Q8MIE9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/TGIF homeobox family.|||May have a transcription role in testis.|||Nucleus http://togogenome.org/gene/9595:PPP4R3B ^@ http://purl.uniprot.org/uniprot/A0A2I2YLP1|||http://purl.uniprot.org/uniprot/A0A2I2ZQH2|||http://purl.uniprot.org/uniprot/G3RFF6 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/9595:MUS81 ^@ http://purl.uniprot.org/uniprot/G3R5H8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XPF family.|||Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).|||Interacts with EME1.|||Nucleus http://togogenome.org/gene/9595:STXBP5L ^@ http://purl.uniprot.org/uniprot/A0A2I2ZJA0|||http://purl.uniprot.org/uniprot/G3SKU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat L(2)GL family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9595:WFIKKN2 ^@ http://purl.uniprot.org/uniprot/G3RT83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WFIKKN family.|||Secreted http://togogenome.org/gene/9595:LIX1 ^@ http://purl.uniprot.org/uniprot/G3R9W1 ^@ Similarity ^@ Belongs to the LIX1 family. http://togogenome.org/gene/9595:UGT1A6 ^@ http://purl.uniprot.org/uniprot/G3SFS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9595:NPLOC4 ^@ http://purl.uniprot.org/uniprot/G3SGZ9 ^@ Similarity ^@ Belongs to the NPL4 family. http://togogenome.org/gene/9595:MRPS15 ^@ http://purl.uniprot.org/uniprot/G3RCK0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/9595:WNT5B ^@ http://purl.uniprot.org/uniprot/A0A2I2Z2N4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9595:CRHR1 ^@ http://purl.uniprot.org/uniprot/G3RR87 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.|||Membrane http://togogenome.org/gene/9595:GABARAPL1 ^@ http://purl.uniprot.org/uniprot/G3RMN7 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9595:SPR ^@ http://purl.uniprot.org/uniprot/G3QSC9 ^@ Similarity ^@ Belongs to the sepiapterin reductase family. http://togogenome.org/gene/9595:TNS1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YUW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTEN phosphatase protein family.|||focal adhesion http://togogenome.org/gene/9595:VAT1 ^@ http://purl.uniprot.org/uniprot/G3RZ64 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/9595:GABRA5 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZHK1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9595:SQLE ^@ http://purl.uniprot.org/uniprot/G3QWK3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the squalene monooxygenase family.|||Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9595:SEC11C ^@ http://purl.uniprot.org/uniprot/G3RP59 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Component of the signal peptidase complex.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:RSPO4 ^@ http://purl.uniprot.org/uniprot/G3QV07 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/9595:ABLIM1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YFZ2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:GCDH ^@ http://purl.uniprot.org/uniprot/G3QLJ4 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9595:CDNF ^@ http://purl.uniprot.org/uniprot/G3QEZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARMET family.|||Secreted http://togogenome.org/gene/9595:ORC4 ^@ http://purl.uniprot.org/uniprot/G3S8X6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC4 family.|||Component of the origin recognition complex (ORC) that binds origins of replication.|||Nucleus http://togogenome.org/gene/9595:CHCHD4 ^@ http://purl.uniprot.org/uniprot/A0A2I2YA31|||http://purl.uniprot.org/uniprot/G3RUL9 ^@ Subcellular Location Annotation ^@ Mitochondrion intermembrane space http://togogenome.org/gene/9595:ACSS2 ^@ http://purl.uniprot.org/uniprot/G3QVL5|||http://purl.uniprot.org/uniprot/G3RQA9 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9595:MACIR ^@ http://purl.uniprot.org/uniprot/A0A2I2Z2P1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UNC119-binding protein family.|||Cytoplasm|||cilium http://togogenome.org/gene/9595:RDH5 ^@ http://purl.uniprot.org/uniprot/G3QKX8 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9595:LOC101125840 ^@ http://purl.uniprot.org/uniprot/G3SGM5 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9595:ISY1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZEJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ISY1 family.|||Nucleus http://togogenome.org/gene/9595:TNFRSF11A ^@ http://purl.uniprot.org/uniprot/A0A2I2ZGI0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:STAT3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z8R2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:NFYA ^@ http://purl.uniprot.org/uniprot/A0A2I2Z8C6|||http://purl.uniprot.org/uniprot/G3QZI1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NFYA/HAP2 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.|||Heterotrimer.|||Nucleus http://togogenome.org/gene/9595:CAD ^@ http://purl.uniprot.org/uniprot/G3R7L6 ^@ Similarity ^@ In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily. http://togogenome.org/gene/9595:GTF2H4 ^@ http://purl.uniprot.org/uniprot/G3REB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB2 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.|||Nucleus http://togogenome.org/gene/9595:PARVG ^@ http://purl.uniprot.org/uniprot/G3RK33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the parvin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:CFAP144 ^@ http://purl.uniprot.org/uniprot/G3R5N2 ^@ Similarity ^@ Belongs to the CFAP144 family. http://togogenome.org/gene/9595:LOC101131774 ^@ http://purl.uniprot.org/uniprot/G3QL45 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9595:SUV39H1 ^@ http://purl.uniprot.org/uniprot/G3S7R4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.|||Nucleus|||centromere http://togogenome.org/gene/9595:LOC101125919 ^@ http://purl.uniprot.org/uniprot/G3S4R9 ^@ Similarity ^@ Belongs to the Speedy/Ringo family. http://togogenome.org/gene/9595:SGO1 ^@ http://purl.uniprot.org/uniprot/G3QU50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shugoshin family.|||centromere http://togogenome.org/gene/9595:RPS6KA6 ^@ http://purl.uniprot.org/uniprot/G3RSV7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9595:CX3CL1 ^@ http://purl.uniprot.org/uniprot/G3QE79 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9595:SEPSECS ^@ http://purl.uniprot.org/uniprot/G3RRL9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SepSecS family.|||Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.|||Cytoplasm|||Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer. http://togogenome.org/gene/9595:CAT ^@ http://purl.uniprot.org/uniprot/G3R538 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the catalase family.|||Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.|||Peroxisome http://togogenome.org/gene/9595:NEIL3 ^@ http://purl.uniprot.org/uniprot/G3RKV9 ^@ Similarity ^@ Belongs to the FPG family. http://togogenome.org/gene/9595:INIP ^@ http://purl.uniprot.org/uniprot/A0A2I2YNT7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SOSS-C family.|||Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).|||Component of the SOSS complex.|||Nucleus http://togogenome.org/gene/9595:SMG9 ^@ http://purl.uniprot.org/uniprot/G3QDU3 ^@ Similarity ^@ Belongs to the SMG9 family. http://togogenome.org/gene/9595:PIGC ^@ http://purl.uniprot.org/uniprot/G3RVE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGC family.|||Membrane http://togogenome.org/gene/9595:ADCY7 ^@ http://purl.uniprot.org/uniprot/G3RFS8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/9595:TMEM116 ^@ http://purl.uniprot.org/uniprot/G3QMI8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:ENTPD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZQ76|||http://purl.uniprot.org/uniprot/G3QRI2 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9595:C6 ^@ http://purl.uniprot.org/uniprot/G3QYV7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complement C6/C7/C8/C9 family.|||Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and 12-14 copies of the pore-forming subunit C9.|||Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9595:C4H4orf47 ^@ http://purl.uniprot.org/uniprot/G3SH45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP96 family.|||centrosome http://togogenome.org/gene/9595:UCHL3 ^@ http://purl.uniprot.org/uniprot/G3SEB1 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/9595:ALG13 ^@ http://purl.uniprot.org/uniprot/A0A2I2YN31|||http://purl.uniprot.org/uniprot/A0A2I2ZS30 ^@ Similarity ^@ Belongs to the glycosyltransferase 28 family. http://togogenome.org/gene/9595:PNLDC1 ^@ http://purl.uniprot.org/uniprot/G3RTT7 ^@ Similarity ^@ Belongs to the CAF1 family. http://togogenome.org/gene/9595:GAP43 ^@ http://purl.uniprot.org/uniprot/A0A2I2YYA5|||http://purl.uniprot.org/uniprot/G3SJC5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the neuromodulin family.|||Cell membrane|||Cytoplasm|||Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts (via IQ domain) with calmodulin. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.|||Membrane|||Palmitoylated. Palmitoylation is essential for plasma membrane association.|||Perikaryon|||Synapse|||This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.|||axon|||dendrite|||filopodium membrane|||growth cone membrane http://togogenome.org/gene/9595:SMPD2 ^@ http://purl.uniprot.org/uniprot/G3QLI3 ^@ Similarity ^@ Belongs to the neutral sphingomyelinase family. http://togogenome.org/gene/9595:USP33 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZA16 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family. USP20/USP33 subfamily.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||centrosome|||perinuclear region http://togogenome.org/gene/9595:LOC101140366 ^@ http://purl.uniprot.org/uniprot/G3RAE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:SLC39A1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YJF2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:RAP2A ^@ http://purl.uniprot.org/uniprot/A0A2I2YVG8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Palmitoylated.|||Recycling endosome membrane|||Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. http://togogenome.org/gene/9595:LOC101146638 ^@ http://purl.uniprot.org/uniprot/G3QG39 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9595:TAGLN ^@ http://purl.uniprot.org/uniprot/A0A2I2YBG4 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/9595:OAF ^@ http://purl.uniprot.org/uniprot/G3R041 ^@ Similarity ^@ Belongs to the OAF family. http://togogenome.org/gene/9595:UNC5B ^@ http://purl.uniprot.org/uniprot/G3R7K4|||http://purl.uniprot.org/uniprot/G3RY67 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-5 family.|||Cell membrane|||Membrane|||Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. http://togogenome.org/gene/9595:LOC101149201 ^@ http://purl.uniprot.org/uniprot/G3RHW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ATP6V0D2 ^@ http://purl.uniprot.org/uniprot/G3RD24 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9595:SF1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZUJ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BBP/SF1 family.|||Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.|||Nucleus http://togogenome.org/gene/9595:AGBL5 ^@ http://purl.uniprot.org/uniprot/A0A2I2YHG4|||http://purl.uniprot.org/uniprot/G3RL84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||Midbody|||Nucleus|||cytosol|||spindle http://togogenome.org/gene/9595:JAK2 ^@ http://purl.uniprot.org/uniprot/G3QWD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.|||Cytoplasm|||Endomembrane system|||Nucleus http://togogenome.org/gene/9595:DMGDH ^@ http://purl.uniprot.org/uniprot/G3QL10 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/9595:RPS20 ^@ http://purl.uniprot.org/uniprot/G3QHI2 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Component of the 40S small ribosomal subunit. http://togogenome.org/gene/9595:HSD3B7 ^@ http://purl.uniprot.org/uniprot/G3RIZ9 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9595:DNASE2B ^@ http://purl.uniprot.org/uniprot/G3QY60 ^@ Similarity ^@ Belongs to the DNase II family. http://togogenome.org/gene/9595:MBOAT1 ^@ http://purl.uniprot.org/uniprot/G3REP0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:MMD ^@ http://purl.uniprot.org/uniprot/G3SKA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9595:SLC7A2 ^@ http://purl.uniprot.org/uniprot/G3QWY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:VIRMA ^@ http://purl.uniprot.org/uniprot/G3QVF2 ^@ Similarity ^@ Belongs to the vir family. http://togogenome.org/gene/9595:DNAH7 ^@ http://purl.uniprot.org/uniprot/G3RQK0 ^@ Similarity ^@ Belongs to the dynein heavy chain family. http://togogenome.org/gene/9595:LOC101128282 ^@ http://purl.uniprot.org/uniprot/G3QKK8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:RPS27L ^@ http://purl.uniprot.org/uniprot/G3RVW3 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9595:DUSP5 ^@ http://purl.uniprot.org/uniprot/G3QJK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/9595:LOC101137306 ^@ http://purl.uniprot.org/uniprot/G3RX17 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/9595:CPLX1 ^@ http://purl.uniprot.org/uniprot/G3S2L5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9595:AGO3 ^@ http://purl.uniprot.org/uniprot/G3RD28 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argonaute family. Ago subfamily.|||Interacts with EIF4B, IMP8, PRMT5 and TNRC6B. Interacts with APOBEC3F, APOBEC3G and APOBEC3H.|||P-body|||Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. http://togogenome.org/gene/9595:MYF6 ^@ http://purl.uniprot.org/uniprot/G3QP01 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SARAF ^@ http://purl.uniprot.org/uniprot/G3SGX8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SARAF family.|||Endoplasmic reticulum membrane|||Interacts with STIM1; the interaction is inhibit by th interaction of STIM1 with EFHB.|||Membrane|||Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions. http://togogenome.org/gene/9595:WDR12 ^@ http://purl.uniprot.org/uniprot/G3RQ15 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat WDR12/YTM1 family.|||Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.|||Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9595:TLCD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZNX2|||http://purl.uniprot.org/uniprot/G3RKQ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:TNN ^@ http://purl.uniprot.org/uniprot/G3RBZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tenascin family.|||extracellular matrix http://togogenome.org/gene/9595:FMO2 ^@ http://purl.uniprot.org/uniprot/G3R0K3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9595:ABCC9 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y3H7 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with KCNJ11.|||Membrane http://togogenome.org/gene/9595:HBEGF ^@ http://purl.uniprot.org/uniprot/G3QDG3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:PPM1D ^@ http://purl.uniprot.org/uniprot/G3R0Z4 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9595:CD1C ^@ http://purl.uniprot.org/uniprot/G3QE10 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9595:MRPL1 ^@ http://purl.uniprot.org/uniprot/G3QG37 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9595:AJUBA ^@ http://purl.uniprot.org/uniprot/G3RF25 ^@ Similarity ^@ Belongs to the zyxin/ajuba family. http://togogenome.org/gene/9595:CAVIN2 ^@ http://purl.uniprot.org/uniprot/G3QGZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/9595:KIF26A ^@ http://purl.uniprot.org/uniprot/G3S0V0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9595:CFDP1 ^@ http://purl.uniprot.org/uniprot/G3QG69 ^@ Function|||Subcellular Location Annotation ^@ May play a role during embryogenesis.|||kinetochore http://togogenome.org/gene/9595:CD63 ^@ http://purl.uniprot.org/uniprot/G3QKY3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Cell membrane|||Cell surface|||Endosome membrane|||Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.|||Late endosome membrane|||Lysosome membrane|||Melanosome|||Membrane|||extracellular exosome|||multivesicular body http://togogenome.org/gene/9595:MGME1 ^@ http://purl.uniprot.org/uniprot/G3R0S1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGME1 family.|||Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair.|||Mitochondrion http://togogenome.org/gene/9595:G6PC2 ^@ http://purl.uniprot.org/uniprot/G3RG68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9595:LOC101150373 ^@ http://purl.uniprot.org/uniprot/G3RJE1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:MICOS13 ^@ http://purl.uniprot.org/uniprot/A0A2I2YDU8|||http://purl.uniprot.org/uniprot/G3R662 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic13 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9595:TBPL2 ^@ http://purl.uniprot.org/uniprot/G3QFG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBP family.|||Nucleus http://togogenome.org/gene/9595:MDGA2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YKW2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:SERPINB10 ^@ http://purl.uniprot.org/uniprot/G3RAZ6 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9595:LUC7L ^@ http://purl.uniprot.org/uniprot/A0A2I2YWS1 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/9595:RIPPLY2 ^@ http://purl.uniprot.org/uniprot/G3RZS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ripply family.|||Nucleus http://togogenome.org/gene/9595:HINT1 ^@ http://purl.uniprot.org/uniprot/G3R8F9 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/9595:POMT2 ^@ http://purl.uniprot.org/uniprot/G3QTP2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/9595:RPL22 ^@ http://purl.uniprot.org/uniprot/G3S3C9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL22 family. http://togogenome.org/gene/9595:SMIM7 ^@ http://purl.uniprot.org/uniprot/A0A2I2YH81 ^@ Similarity ^@ Belongs to the SMIM7 family. http://togogenome.org/gene/9595:PPP1R11 ^@ http://purl.uniprot.org/uniprot/G3RNA2 ^@ Subunit ^@ Interacts with TLR2 and UBE2D2. http://togogenome.org/gene/9595:RGS4 ^@ http://purl.uniprot.org/uniprot/G3R6X0 ^@ Function ^@ Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. http://togogenome.org/gene/9595:S100A6 ^@ http://purl.uniprot.org/uniprot/G3QWD2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the S-100 family.|||May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.|||Nucleus envelope http://togogenome.org/gene/9595:MS4A3 ^@ http://purl.uniprot.org/uniprot/G3QGD1 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9595:RABGGTB ^@ http://purl.uniprot.org/uniprot/G3QPT1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit beta family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX. http://togogenome.org/gene/9595:SERINC4 ^@ http://purl.uniprot.org/uniprot/G3RFR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9595:MTMR3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1T1|||http://purl.uniprot.org/uniprot/G3QTV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/9595:ETNPPL ^@ http://purl.uniprot.org/uniprot/G3R9E6 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9595:TXLNG ^@ http://purl.uniprot.org/uniprot/G3QIX7 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/9595:PTGES2 ^@ http://purl.uniprot.org/uniprot/G3SK79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GST superfamily.|||Membrane http://togogenome.org/gene/9595:PRKAB1 ^@ http://purl.uniprot.org/uniprot/G3RB90 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/9595:EXOSC9 ^@ http://purl.uniprot.org/uniprot/G3RUC9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:PRPF38B ^@ http://purl.uniprot.org/uniprot/G3R6P3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP38 family.|||May be required for pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/9595:CEP70 ^@ http://purl.uniprot.org/uniprot/G3R5C7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.|||Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.|||centrosome http://togogenome.org/gene/9595:NUBPL ^@ http://purl.uniprot.org/uniprot/G3R2S8 ^@ Similarity ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. http://togogenome.org/gene/9595:LOC101148641 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y8N9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COA8 family.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:LGSN ^@ http://purl.uniprot.org/uniprot/A0A2I2ZYV7|||http://purl.uniprot.org/uniprot/G3QMX0 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/9595:CBX3 ^@ http://purl.uniprot.org/uniprot/G3RV49 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:DPP4 ^@ http://purl.uniprot.org/uniprot/G3SI68 ^@ Subcellular Location Annotation ^@ Cell membrane|||invadopodium membrane|||lamellipodium membrane http://togogenome.org/gene/9595:CAVIN4 ^@ http://purl.uniprot.org/uniprot/G3R2G8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/9595:MAL ^@ http://purl.uniprot.org/uniprot/G3QTU5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:PACSIN2 ^@ http://purl.uniprot.org/uniprot/G3RJL7|||http://purl.uniprot.org/uniprot/G3SBB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PACSIN family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Early endosome|||Endosome membrane|||Membrane|||Recycling endosome membrane|||caveola|||cytoskeleton|||ruffle membrane http://togogenome.org/gene/9595:CRYGN ^@ http://purl.uniprot.org/uniprot/G3RFE2 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9595:CDK5RAP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y5L0|||http://purl.uniprot.org/uniprot/G3QD67 ^@ Subcellular Location Annotation ^@ Golgi apparatus|||centrosome http://togogenome.org/gene/9595:ADCY3 ^@ http://purl.uniprot.org/uniprot/G3QN93 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/9595:CDCA7L ^@ http://purl.uniprot.org/uniprot/A0A2I2Z875 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9595:APC ^@ http://purl.uniprot.org/uniprot/G3RRG6 ^@ Similarity ^@ Belongs to the adenomatous polyposis coli (APC) family. http://togogenome.org/gene/9595:NMBR ^@ http://purl.uniprot.org/uniprot/G3QF03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:INSL4 ^@ http://purl.uniprot.org/uniprot/G3RYG6 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9595:VIM ^@ http://purl.uniprot.org/uniprot/G3R2A8 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:PPP1R2C ^@ http://purl.uniprot.org/uniprot/A0A2I2ZYY3 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 2 family. http://togogenome.org/gene/9595:LOC101148018 ^@ http://purl.uniprot.org/uniprot/G3RMA8 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9595:ELF1 ^@ http://purl.uniprot.org/uniprot/G3R5C2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9595:CPT1C ^@ http://purl.uniprot.org/uniprot/G3R966 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the carnitine/choline acetyltransferase family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9595:ANG ^@ http://purl.uniprot.org/uniprot/A0A2I2YL38 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9595:PDIA4 ^@ http://purl.uniprot.org/uniprot/G3RY30 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen|||Part of a large chaperone multiprotein complex. http://togogenome.org/gene/9595:CFAP418 ^@ http://purl.uniprot.org/uniprot/G3QXT9 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in photoreceptor outer segment disk morphogenesis.|||Photoreceptor inner segment http://togogenome.org/gene/9595:TTC39C ^@ http://purl.uniprot.org/uniprot/A0A2I2Y9C8 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/9595:NFIA ^@ http://purl.uniprot.org/uniprot/A0A2I2ZR22 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTF/NF-I family.|||Binds DNA as a homodimer.|||Nucleus|||Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. http://togogenome.org/gene/9595:MCM5 ^@ http://purl.uniprot.org/uniprot/G3R2J0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/9595:NUDC ^@ http://purl.uniprot.org/uniprot/G3RH24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nudC family.|||Midbody|||spindle http://togogenome.org/gene/9595:XPO1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZAW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm http://togogenome.org/gene/9595:C12H12orf43 ^@ http://purl.uniprot.org/uniprot/A0A2I2YJN0|||http://purl.uniprot.org/uniprot/G3R8U7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUSTOS family.|||Nucleus envelope http://togogenome.org/gene/9595:ATP5F1D ^@ http://purl.uniprot.org/uniprot/G3QIS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase epsilon chain family.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:LOC101138131 ^@ http://purl.uniprot.org/uniprot/G3RD39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:USB1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YWK7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 2H phosphoesterase superfamily. USB1 family.|||Nucleus|||Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. http://togogenome.org/gene/9595:SERPINA10 ^@ http://purl.uniprot.org/uniprot/G3QJZ0 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9595:RUNDC3B ^@ http://purl.uniprot.org/uniprot/G3SKQ3 ^@ Similarity|||Subunit ^@ Belongs to the RUNDC3 family.|||Interacts with RAP2A. http://togogenome.org/gene/9595:EHD2 ^@ http://purl.uniprot.org/uniprot/G3S6K4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/9595:COPS6 ^@ http://purl.uniprot.org/uniprot/G3QJT5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M67A family. CSN6 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:POLL ^@ http://purl.uniprot.org/uniprot/A0A2I2YH39|||http://purl.uniprot.org/uniprot/G3QQQ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.|||Nucleus http://togogenome.org/gene/9595:ATP5MC1 ^@ http://purl.uniprot.org/uniprot/G3QGY6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/9595:SLC13A2 ^@ http://purl.uniprot.org/uniprot/G3S4A6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/9595:MATN2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZDD6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:DNASE1L1 ^@ http://purl.uniprot.org/uniprot/G3QD27 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/9595:HOXD10 ^@ http://purl.uniprot.org/uniprot/G3QG73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9595:DGLUCY ^@ http://purl.uniprot.org/uniprot/G3RH17 ^@ Similarity ^@ Belongs to the D-glutamate cyclase family. http://togogenome.org/gene/9595:CREM ^@ http://purl.uniprot.org/uniprot/A0A2I2ZBG3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SLC7A11 ^@ http://purl.uniprot.org/uniprot/G3SDE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:FOXH1 ^@ http://purl.uniprot.org/uniprot/G3RJH9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:IL2RA ^@ http://purl.uniprot.org/uniprot/G3S435 ^@ Caution|||Function|||Subunit ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.|||Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. http://togogenome.org/gene/9595:ACVRL1 ^@ http://purl.uniprot.org/uniprot/G3QUV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9595:DGUOK ^@ http://purl.uniprot.org/uniprot/G3QN24|||http://purl.uniprot.org/uniprot/G3SIQ2 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/9595:DCP1A ^@ http://purl.uniprot.org/uniprot/G3RAN0 ^@ Similarity ^@ Belongs to the DCP1 family. http://togogenome.org/gene/9595:TNP2 ^@ http://purl.uniprot.org/uniprot/G3S4Q5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear transition protein 2 family.|||Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.|||nucleolus http://togogenome.org/gene/9595:LONP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YEF8|||http://purl.uniprot.org/uniprot/G3QUL8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.|||Belongs to the peptidase S16 family.|||Interacts with PEX5. Interacts with TYSND1.|||Peroxisome matrix http://togogenome.org/gene/9595:BTF3L4 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZQ01 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/9595:DDIT4L ^@ http://purl.uniprot.org/uniprot/A0A2I2YCQ7 ^@ Similarity ^@ Belongs to the DDIT4 family. http://togogenome.org/gene/9595:TARBP2 ^@ http://purl.uniprot.org/uniprot/G3RA71 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TARBP2 family.|||Cytoplasm|||Nucleus|||Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.|||Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC).|||perinuclear region http://togogenome.org/gene/9595:ESCO1 ^@ http://purl.uniprot.org/uniprot/G3QG44 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:HS6ST1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YYD2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.|||Belongs to the sulfotransferase 6 family.|||Membrane http://togogenome.org/gene/9595:TMEM181 ^@ http://purl.uniprot.org/uniprot/G3QCZ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:TMEM184C ^@ http://purl.uniprot.org/uniprot/G3S4P8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:FGF14 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y2V3|||http://purl.uniprot.org/uniprot/G3QVB3 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9595:FAM53A ^@ http://purl.uniprot.org/uniprot/A0A2I2Z3V3 ^@ Similarity ^@ Belongs to the FAM53 family. http://togogenome.org/gene/9595:PNN ^@ http://purl.uniprot.org/uniprot/G3SBD1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pinin family.|||Found in a mRNA splicing-dependent exon junction complex (EJC). Found in a complex with SR proteins. Found in a mRNP complex with RNPS1. Component of the PSAP complex consisting of RNPS1, SAP18 and PNN. Interacts with PNISR, CTBP1, CTBP2, KRT8, KRT18, KRT19, PS1D/PNO40, PPIG, RNPS1, SFRS4 and SRRM2. Identified in the spliceosome C complex.|||Nucleus speckle|||desmosome http://togogenome.org/gene/9595:SLC30A10 ^@ http://purl.uniprot.org/uniprot/G3R250 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9595:GADD45GIP1 ^@ http://purl.uniprot.org/uniprot/G3RS84 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.|||Belongs to the mitochondrion-specific ribosomal protein mL64 family.|||Mitochondrion|||Nucleus http://togogenome.org/gene/9595:LBH ^@ http://purl.uniprot.org/uniprot/G3QGJ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LBH family.|||Cytoplasm|||Nucleus|||Transcriptional activator. http://togogenome.org/gene/9595:TTC9B ^@ http://purl.uniprot.org/uniprot/G3QGC2 ^@ Similarity ^@ Belongs to the TTC9 family. http://togogenome.org/gene/9595:GRIK2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z6L3|||http://purl.uniprot.org/uniprot/G3QD09 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9595:RNF167 ^@ http://purl.uniprot.org/uniprot/G3QDA6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:BEND6 ^@ http://purl.uniprot.org/uniprot/G3QES8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SLC26A3 ^@ http://purl.uniprot.org/uniprot/G3QUI4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.|||Membrane http://togogenome.org/gene/9595:TMED3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YSV8|||http://purl.uniprot.org/uniprot/G3R3A7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9595:LOC101127189 ^@ http://purl.uniprot.org/uniprot/G3QD36 ^@ Function|||Similarity ^@ Belongs to the peptidase A1 family.|||Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. http://togogenome.org/gene/9595:POLR2K ^@ http://purl.uniprot.org/uniprot/G3RT57 ^@ Similarity ^@ Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family. http://togogenome.org/gene/9595:LHX5 ^@ http://purl.uniprot.org/uniprot/G3R4V4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:CLCC1 ^@ http://purl.uniprot.org/uniprot/G3QR45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel MCLC family.|||Membrane http://togogenome.org/gene/9595:CAB39L ^@ http://purl.uniprot.org/uniprot/G3QE78 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mo25 family.|||Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.|||Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. http://togogenome.org/gene/9595:FUBP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y888 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SHFL ^@ http://purl.uniprot.org/uniprot/G3SE10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SHFL family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:CASP4 ^@ http://purl.uniprot.org/uniprot/A0A2I2YB08 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9595:CNR2 ^@ http://purl.uniprot.org/uniprot/G3SC46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ISOC1 ^@ http://purl.uniprot.org/uniprot/G3RAI7 ^@ Similarity ^@ Belongs to the isochorismatase family. http://togogenome.org/gene/9595:VCL ^@ http://purl.uniprot.org/uniprot/A0A2I2ZYW7|||http://purl.uniprot.org/uniprot/G3R689 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.|||Belongs to the vinculin/alpha-catenin family.|||Cell membrane|||Membrane|||adherens junction|||podosome http://togogenome.org/gene/9595:DCC ^@ http://purl.uniprot.org/uniprot/G3QWN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. DCC family.|||Membrane http://togogenome.org/gene/9595:IRAK4 ^@ http://purl.uniprot.org/uniprot/G3RYR9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.|||Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.|||Cytoplasm|||Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. http://togogenome.org/gene/9595:LYPD2 ^@ http://purl.uniprot.org/uniprot/G3RTI8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:SEC22A ^@ http://purl.uniprot.org/uniprot/A0A2I2Z5V2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||May be involved in vesicle transport between the ER and the Golgi complex.|||Membrane http://togogenome.org/gene/9595:GTF2H5 ^@ http://purl.uniprot.org/uniprot/G3RTK3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB5 family.|||Component of the 7-subunit TFIIH core complex.|||In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.|||Nucleus http://togogenome.org/gene/9595:DRC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y2J8|||http://purl.uniprot.org/uniprot/G3QCR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC1 family.|||cilium axoneme|||flagellum axoneme http://togogenome.org/gene/9595:GLP2R ^@ http://purl.uniprot.org/uniprot/G3QZN1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:MIX23 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZR55 ^@ Similarity ^@ Belongs to the MIX23 family. http://togogenome.org/gene/9595:SLU7 ^@ http://purl.uniprot.org/uniprot/G3QS51 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the SLU7 family.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/9595:BCL2L11 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZL36 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Bcl-2 family.|||Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1.|||Induces apoptosis and anoikis. http://togogenome.org/gene/9595:RRAGC ^@ http://purl.uniprot.org/uniprot/A0A2I2ZGZ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/9595:INHBB ^@ http://purl.uniprot.org/uniprot/G3RH13 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/9595:CFTR ^@ http://purl.uniprot.org/uniprot/G3S0G2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.|||Cell membrane|||Early endosome membrane|||Endoplasmic reticulum membrane|||Endosome membrane|||Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.|||Membrane|||Recycling endosome membrane http://togogenome.org/gene/9595:SDHAF4 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZY75 ^@ Similarity ^@ Belongs to the SDHAF4 family. http://togogenome.org/gene/9595:SNX31 ^@ http://purl.uniprot.org/uniprot/G3SJX2 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9595:CCL18 ^@ http://purl.uniprot.org/uniprot/G3R869 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9595:MICOS10 ^@ http://purl.uniprot.org/uniprot/G3QWM9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic10 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:BRINP2 ^@ http://purl.uniprot.org/uniprot/G3QGV4 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/9595:PHC2 ^@ http://purl.uniprot.org/uniprot/G3S4V0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:TULP2 ^@ http://purl.uniprot.org/uniprot/G3QU03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TUB family.|||Secreted http://togogenome.org/gene/9595:UTP3 ^@ http://purl.uniprot.org/uniprot/G3RXB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAS10 family.|||nucleolus http://togogenome.org/gene/9595:PCYT1B ^@ http://purl.uniprot.org/uniprot/A0A2I2YXF2|||http://purl.uniprot.org/uniprot/A0A2I2ZIJ5|||http://purl.uniprot.org/uniprot/G3QIZ0 ^@ Function|||Similarity ^@ Belongs to the cytidylyltransferase family.|||Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. http://togogenome.org/gene/9595:LOC101129299 ^@ http://purl.uniprot.org/uniprot/G3RVC1 ^@ Similarity ^@ Belongs to the cytochrome c oxidase VIIa family. http://togogenome.org/gene/9595:ODAM ^@ http://purl.uniprot.org/uniprot/G3QY18 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ODAM family.|||Cytoplasm|||Interacts (via C-terminus) with ARHGEF5.|||Nucleus|||Secreted|||Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface. http://togogenome.org/gene/9595:LOC101143962 ^@ http://purl.uniprot.org/uniprot/G3RXM3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9595:SPTA1 ^@ http://purl.uniprot.org/uniprot/G3QE19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the spectrin family.|||cell cortex|||cytoskeleton http://togogenome.org/gene/9595:CD40 ^@ http://purl.uniprot.org/uniprot/G3S851 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:BEST2 ^@ http://purl.uniprot.org/uniprot/G3QS17 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms calcium-sensitive chloride channels. Permeable to bicarbonate.|||Membrane http://togogenome.org/gene/9595:NPM3 ^@ http://purl.uniprot.org/uniprot/G3SF36 ^@ Similarity ^@ Belongs to the nucleoplasmin family. http://togogenome.org/gene/9595:GRIK3 ^@ http://purl.uniprot.org/uniprot/G3R6R5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9595:FAM221B ^@ http://purl.uniprot.org/uniprot/G3R6M7 ^@ Similarity ^@ Belongs to the FAM221 family. http://togogenome.org/gene/9595:RBFOX1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z094|||http://purl.uniprot.org/uniprot/A0A2I2ZYE3 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||RNA-binding protein that regulates alternative splicing events. http://togogenome.org/gene/9595:SLC41A3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YBN2|||http://purl.uniprot.org/uniprot/A0A2I2ZLE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/9595:GGA3 ^@ http://purl.uniprot.org/uniprot/G3QXC9|||http://purl.uniprot.org/uniprot/G3SG97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GGA protein family.|||Early endosome membrane|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9595:B3GAT2 ^@ http://purl.uniprot.org/uniprot/G3S6M8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:SMCO4 ^@ http://purl.uniprot.org/uniprot/G3R6D6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMCO4 family.|||Membrane http://togogenome.org/gene/9595:LOC101141508 ^@ http://purl.uniprot.org/uniprot/G3R2E6 ^@ Similarity ^@ Belongs to the SKP1 family. http://togogenome.org/gene/9595:NRDC ^@ http://purl.uniprot.org/uniprot/G3SK41 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/9595:SGSH ^@ http://purl.uniprot.org/uniprot/G3RBT8 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9595:UBAP2L ^@ http://purl.uniprot.org/uniprot/A0A2I2YEW6|||http://purl.uniprot.org/uniprot/A0A2I2ZBZ6|||http://purl.uniprot.org/uniprot/G3RKS4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:PPIC ^@ http://purl.uniprot.org/uniprot/G3QFM7 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9595:CLPS ^@ http://purl.uniprot.org/uniprot/G3QRE9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.|||Enterostatin has a biological activity as a satiety signal.|||Forms a 1:1 stoichiometric complex with pancreatic lipase.|||Secreted http://togogenome.org/gene/9595:ACTA2 ^@ http://purl.uniprot.org/uniprot/G3RC70 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9595:ADSS1 ^@ http://purl.uniprot.org/uniprot/G3SA31 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.|||Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. http://togogenome.org/gene/9595:LOC101134267 ^@ http://purl.uniprot.org/uniprot/G3SIB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ECHDC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YVU6|||http://purl.uniprot.org/uniprot/A0A2I2ZJM0 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9595:NR1I3 ^@ http://purl.uniprot.org/uniprot/G3QSG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9595:CTNNA1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z4W8 ^@ Similarity ^@ Belongs to the vinculin/alpha-catenin family. http://togogenome.org/gene/9595:MST1 ^@ http://purl.uniprot.org/uniprot/G3R4W6 ^@ Caution|||Similarity ^@ Belongs to the peptidase S1 family. Plasminogen subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:ASB11 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z203|||http://purl.uniprot.org/uniprot/G3QWH5 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9595:PPP1R12B ^@ http://purl.uniprot.org/uniprot/G3QPB2|||http://purl.uniprot.org/uniprot/G3S5C3 ^@ Subcellular Location Annotation|||Subunit ^@ PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.|||stress fiber http://togogenome.org/gene/9595:IGHMBP2 ^@ http://purl.uniprot.org/uniprot/G3R8W9 ^@ Similarity ^@ Belongs to the DNA2/NAM7 helicase family. http://togogenome.org/gene/9595:DYRK3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YH27|||http://purl.uniprot.org/uniprot/G3R9M2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. http://togogenome.org/gene/9595:PPIL6 ^@ http://purl.uniprot.org/uniprot/A0A2I2YLV2 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9595:D2HGDH ^@ http://purl.uniprot.org/uniprot/A0A2I2ZSP4|||http://purl.uniprot.org/uniprot/G3REF1 ^@ Similarity ^@ Belongs to the FAD-binding oxidoreductase/transferase type 4 family. http://togogenome.org/gene/9595:ISX ^@ http://purl.uniprot.org/uniprot/A0A2I2YIM0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:ERI1 ^@ http://purl.uniprot.org/uniprot/G3RBA0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:CCL25 ^@ http://purl.uniprot.org/uniprot/G3QRC6 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9595:COL4A5 ^@ http://purl.uniprot.org/uniprot/A0A2I2YBW5 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.|||basement membrane http://togogenome.org/gene/9595:UTP14A ^@ http://purl.uniprot.org/uniprot/G3RG35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP14 family.|||nucleolus http://togogenome.org/gene/9595:POLD2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YZZ9|||http://purl.uniprot.org/uniprot/A0A2I2ZL09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase delta/II small subunit family.|||Nucleus http://togogenome.org/gene/9595:MNAT1 ^@ http://purl.uniprot.org/uniprot/G3R164 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with CDK7 and cyclin H.|||Nucleus|||Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. http://togogenome.org/gene/9595:GRB7 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZI90|||http://purl.uniprot.org/uniprot/G3RMB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRB7/10/14 family.|||Cytoplasm http://togogenome.org/gene/9595:TPD52L1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y4Z3|||http://purl.uniprot.org/uniprot/A0A2I2YHZ0|||http://purl.uniprot.org/uniprot/A0A2I2YPJ0|||http://purl.uniprot.org/uniprot/A0A2I2Z8J6|||http://purl.uniprot.org/uniprot/A0A2I2ZCI0|||http://purl.uniprot.org/uniprot/G3QQ90 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/9595:MSN ^@ http://purl.uniprot.org/uniprot/G3SAW9 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/9595:DCP2 ^@ http://purl.uniprot.org/uniprot/G3S8R2 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DCP2 subfamily. http://togogenome.org/gene/9595:TSG101 ^@ http://purl.uniprot.org/uniprot/G3R4B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.|||Membrane http://togogenome.org/gene/9595:ZFPL1 ^@ http://purl.uniprot.org/uniprot/G3QJQ6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ZFPL1 family.|||Interacts with GOLGA2/GM130.|||Membrane|||Required for cis-Golgi integrity and efficient ER to Golgi transport.|||The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.|||cis-Golgi network membrane http://togogenome.org/gene/9595:SPOPL ^@ http://purl.uniprot.org/uniprot/G3SJ46 ^@ Similarity ^@ Belongs to the Tdpoz family. http://togogenome.org/gene/9595:NPC1 ^@ http://purl.uniprot.org/uniprot/G3SJE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the patched family.|||Membrane http://togogenome.org/gene/9595:UBA1 ^@ http://purl.uniprot.org/uniprot/G3QX61 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/9595:LOC101140733 ^@ http://purl.uniprot.org/uniprot/A0A2I2YTF8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9595:CHCHD6 ^@ http://purl.uniprot.org/uniprot/G3R116 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic25 subfamily.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9595:CTSW ^@ http://purl.uniprot.org/uniprot/G3R5J8 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/9595:XYLT2 ^@ http://purl.uniprot.org/uniprot/G3RN97 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 14 family. XylT subfamily.|||Golgi apparatus membrane|||Membrane|||Monomer. http://togogenome.org/gene/9595:SERPINA9 ^@ http://purl.uniprot.org/uniprot/G3R098 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9595:LOC101134783 ^@ http://purl.uniprot.org/uniprot/G3QGF9 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9595:PHF19 ^@ http://purl.uniprot.org/uniprot/G3QIN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Polycomblike family.|||Nucleus http://togogenome.org/gene/9595:GHSR ^@ http://purl.uniprot.org/uniprot/G3SFQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:LOC101127173 ^@ http://purl.uniprot.org/uniprot/G3QE29 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9595:SPATA6 ^@ http://purl.uniprot.org/uniprot/A0A2I2YIE2 ^@ Similarity ^@ Belongs to the SPATA6 family. http://togogenome.org/gene/9595:CNRIP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZFD8|||http://purl.uniprot.org/uniprot/G3RQU5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CNRIP family.|||Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.|||Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. http://togogenome.org/gene/9595:CXCL1 ^@ http://purl.uniprot.org/uniprot/G3QLE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9595:CHRNA9 ^@ http://purl.uniprot.org/uniprot/G3RK67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9595:RPL23A ^@ http://purl.uniprot.org/uniprot/G3SDX8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/9595:ENTPD5 ^@ http://purl.uniprot.org/uniprot/G3REN1 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9595:PADI6 ^@ http://purl.uniprot.org/uniprot/G3RGX7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein arginine deiminase family.|||Catalyzes the deimination of arginine residues of proteins.|||Cytoplasm http://togogenome.org/gene/9595:MTG1 ^@ http://purl.uniprot.org/uniprot/G3S223 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.|||Mitochondrion inner membrane|||Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity. http://togogenome.org/gene/9595:CDS2 ^@ http://purl.uniprot.org/uniprot/G3R9G7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Membrane http://togogenome.org/gene/9595:ACAD11 ^@ http://purl.uniprot.org/uniprot/G3RX63 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9595:TFB1M ^@ http://purl.uniprot.org/uniprot/G3R924 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.|||Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.|||S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. http://togogenome.org/gene/9595:MIP ^@ http://purl.uniprot.org/uniprot/G3RKA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9595:SLC25A20 ^@ http://purl.uniprot.org/uniprot/G3RW72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9595:MCL1 ^@ http://purl.uniprot.org/uniprot/G3RJ78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Cytoplasm|||nucleoplasm http://togogenome.org/gene/9595:UPP1 ^@ http://purl.uniprot.org/uniprot/G3RQE9 ^@ Function|||Similarity ^@ Belongs to the PNP/UDP phosphorylase family.|||Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. http://togogenome.org/gene/9595:HJV ^@ http://purl.uniprot.org/uniprot/G3QQH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the repulsive guidance molecule (RGM) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:GEM ^@ http://purl.uniprot.org/uniprot/G3RB61 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/9595:TMEM126A ^@ http://purl.uniprot.org/uniprot/G3RZH3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:MYOZ1 ^@ http://purl.uniprot.org/uniprot/G3RXC8 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/9595:FAM114A1 ^@ http://purl.uniprot.org/uniprot/G3R9J7 ^@ Similarity ^@ Belongs to the FAM114 family. http://togogenome.org/gene/9595:CENPL ^@ http://purl.uniprot.org/uniprot/A0A2I2Z0S5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-L/IML3 family.|||Nucleus http://togogenome.org/gene/9595:SSR2 ^@ http://purl.uniprot.org/uniprot/G3S0V7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-beta family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/9595:RABAC1 ^@ http://purl.uniprot.org/uniprot/G3QMX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/9595:LOC101134441 ^@ http://purl.uniprot.org/uniprot/G3QJR7 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9595:KIF5A ^@ http://purl.uniprot.org/uniprot/A0A2I2Y2E7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9595:LOC101149205 ^@ http://purl.uniprot.org/uniprot/G3QL69 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:WLS ^@ http://purl.uniprot.org/uniprot/G3S8B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the wntless family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:APOC4 ^@ http://purl.uniprot.org/uniprot/G3RP87 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the apolipoprotein C4 family.|||May participate in lipoprotein metabolism.|||Secreted http://togogenome.org/gene/9595:LHX2 ^@ http://purl.uniprot.org/uniprot/G3QZH4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:ELP6 ^@ http://purl.uniprot.org/uniprot/G3R5Z3 ^@ Similarity ^@ Belongs to the ELP6 family. http://togogenome.org/gene/9595:PURG ^@ http://purl.uniprot.org/uniprot/A0A2I2ZCM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PUR DNA-binding protein family.|||Nucleus http://togogenome.org/gene/9595:LOC101128235 ^@ http://purl.uniprot.org/uniprot/G3QLV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:AMDHD1 ^@ http://purl.uniprot.org/uniprot/G3QVE4 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. HutI family. http://togogenome.org/gene/9595:FTH1 ^@ http://purl.uniprot.org/uniprot/G3RMF9 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/9595:SIX2 ^@ http://purl.uniprot.org/uniprot/G3QZU3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:CDS1 ^@ http://purl.uniprot.org/uniprot/G3QJ06 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Membrane http://togogenome.org/gene/9595:EFHB ^@ http://purl.uniprot.org/uniprot/G3S617 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9595:GPR146 ^@ http://purl.uniprot.org/uniprot/G3RAB8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:ACAN ^@ http://purl.uniprot.org/uniprot/G3QRB2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aggrecan/versican proteoglycan family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9595:PLA2G2F ^@ http://purl.uniprot.org/uniprot/G3RD85 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9595:NUCB2 ^@ http://purl.uniprot.org/uniprot/G3QSY6 ^@ Similarity ^@ Belongs to the nucleobindin family. http://togogenome.org/gene/9595:LOC101154437 ^@ http://purl.uniprot.org/uniprot/G3SAS7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin family.|||Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.|||centrosome http://togogenome.org/gene/9595:GTF2H1 ^@ http://purl.uniprot.org/uniprot/G3RPJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB1 family.|||Nucleus http://togogenome.org/gene/9595:LOC101141065 ^@ http://purl.uniprot.org/uniprot/G3S5B3 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9595:TMEM63B ^@ http://purl.uniprot.org/uniprot/A0A2I2ZSJ5|||http://purl.uniprot.org/uniprot/G3QKP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/9595:MUTYH ^@ http://purl.uniprot.org/uniprot/G3SJD1 ^@ Cofactor|||Function|||Similarity ^@ Adenine glycosylase active on G-A mispairs.|||Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/9595:NMUR1 ^@ http://purl.uniprot.org/uniprot/G3RJE8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for the neuromedin-U and neuromedin-S neuropeptides. http://togogenome.org/gene/9595:SENP6 ^@ http://purl.uniprot.org/uniprot/A0A2I2YT14|||http://purl.uniprot.org/uniprot/A0A2I2ZYU6 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/9595:GPR37 ^@ http://purl.uniprot.org/uniprot/G3QP20 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:TPP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YHL1|||http://purl.uniprot.org/uniprot/G3QIR8 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9595:EEF1B2 ^@ http://purl.uniprot.org/uniprot/G3QVR9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the EF-1-beta/EF-1-delta family.|||EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.|||EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. http://togogenome.org/gene/9595:ZFX ^@ http://purl.uniprot.org/uniprot/A0A2I2ZRW7|||http://purl.uniprot.org/uniprot/G3RRZ5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:PRSS36 ^@ http://purl.uniprot.org/uniprot/G3S8C7 ^@ Function|||Subcellular Location Annotation ^@ Serine protease. Has a preference for substrates with an Arg instead of a Lys residue in position P1.|||extracellular matrix http://togogenome.org/gene/9595:RPS15A ^@ http://purl.uniprot.org/uniprot/G3SAR7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS8 family. http://togogenome.org/gene/9595:SERPINE3 ^@ http://purl.uniprot.org/uniprot/G3QFS8 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9595:PRKAB2 ^@ http://purl.uniprot.org/uniprot/G3SCS5 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/9595:TMEM14A ^@ http://purl.uniprot.org/uniprot/G3QER3 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/9595:RNGTT ^@ http://purl.uniprot.org/uniprot/A0A2I2Z5Q8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.|||In the C-terminal section; belongs to the eukaryotic GTase family.|||In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.|||Nucleus http://togogenome.org/gene/9595:NUDT6 ^@ http://purl.uniprot.org/uniprot/G3S5P7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family.|||Cytoplasm|||May contribute to the regulation of cell proliferation.|||Mitochondrion|||Monomer and homodimer.|||Nucleus http://togogenome.org/gene/9595:SMG8 ^@ http://purl.uniprot.org/uniprot/G3QKH4 ^@ Function|||Similarity ^@ Belongs to the SMG8 family.|||Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. http://togogenome.org/gene/9595:CREG1 ^@ http://purl.uniprot.org/uniprot/G3QIA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CREG family.|||Secreted http://togogenome.org/gene/9595:MRGPRF ^@ http://purl.uniprot.org/uniprot/G3QS36 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:ZNF202 ^@ http://purl.uniprot.org/uniprot/G3QVH3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:TAF1D ^@ http://purl.uniprot.org/uniprot/G3SHA0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF.|||Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.|||Nucleus http://togogenome.org/gene/9595:LOC101127721 ^@ http://purl.uniprot.org/uniprot/G3SAJ6 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9595:CER1 ^@ http://purl.uniprot.org/uniprot/G3QGR9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9595:PABPC5 ^@ http://purl.uniprot.org/uniprot/P60047 ^@ Function|||Subcellular Location Annotation ^@ Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).|||Cytoplasm http://togogenome.org/gene/9595:LOC101139253 ^@ http://purl.uniprot.org/uniprot/G3QR02 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/9595:SMARCAD1 ^@ http://purl.uniprot.org/uniprot/G3SH01 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/9595:SLC9A7 ^@ http://purl.uniprot.org/uniprot/G3R0D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/9595:MVB12A ^@ http://purl.uniprot.org/uniprot/G3SFB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MVB12 family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9595:UBE2K ^@ http://purl.uniprot.org/uniprot/G3QL63 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9595:TIMM9 ^@ http://purl.uniprot.org/uniprot/A0A2I2YZF0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9595:MFRP ^@ http://purl.uniprot.org/uniprot/G3SKK7 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:SART1 ^@ http://purl.uniprot.org/uniprot/G3R206 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNU66/SART1 family.|||Nucleus http://togogenome.org/gene/9595:IFNW1 ^@ http://purl.uniprot.org/uniprot/G3R8Q7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9595:PSMD8 ^@ http://purl.uniprot.org/uniprot/G3QP84 ^@ Similarity ^@ Belongs to the proteasome subunit S14 family. http://togogenome.org/gene/9595:ATP13A4 ^@ http://purl.uniprot.org/uniprot/G3QVX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.|||Membrane http://togogenome.org/gene/9595:KCNJ4 ^@ http://purl.uniprot.org/uniprot/G3QE59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9595:PRDM14 ^@ http://purl.uniprot.org/uniprot/G3R6V8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:MNS1 ^@ http://purl.uniprot.org/uniprot/G3QPS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MNS1 family.|||Nucleus|||cilium axoneme|||flagellum axoneme http://togogenome.org/gene/9595:MX1 ^@ http://purl.uniprot.org/uniprot/G3QGS5 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/9595:PKP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YE74|||http://purl.uniprot.org/uniprot/G3RQ65 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/9595:SYT14 ^@ http://purl.uniprot.org/uniprot/A0A2I2YPP3|||http://purl.uniprot.org/uniprot/G3RUY8 ^@ Similarity ^@ Belongs to the synaptotagmin family. http://togogenome.org/gene/9595:RPL32 ^@ http://purl.uniprot.org/uniprot/G3S4Q3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/9595:ITGB3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZY83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:DPH3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YF98|||http://purl.uniprot.org/uniprot/A0A2I2ZEF9 ^@ Similarity ^@ Belongs to the DPH3 family. http://togogenome.org/gene/9595:MCTS1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZX76|||http://purl.uniprot.org/uniprot/G3R1X1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCTS1 family.|||Cytoplasm http://togogenome.org/gene/9595:OLFML2A ^@ http://purl.uniprot.org/uniprot/G3RY25 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:SAP130 ^@ http://purl.uniprot.org/uniprot/A0A2I2YBL8|||http://purl.uniprot.org/uniprot/G3RJ24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAP130 family.|||Nucleus http://togogenome.org/gene/9595:GCHFR ^@ http://purl.uniprot.org/uniprot/G3QCV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GFRP family.|||Membrane|||Nucleus membrane|||cytosol http://togogenome.org/gene/9595:CAMTA2 ^@ http://purl.uniprot.org/uniprot/G3R1C9 ^@ Similarity|||Subunit ^@ Belongs to the CAMTA family.|||May interact with calmodulin. http://togogenome.org/gene/9595:QRFPR ^@ http://purl.uniprot.org/uniprot/G3QYK8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:NAA40 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y7F3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. NAA40 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:GPR55 ^@ http://purl.uniprot.org/uniprot/G3QIJ0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:PSMC2 ^@ http://purl.uniprot.org/uniprot/G3R1A6 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9595:EPHB4 ^@ http://purl.uniprot.org/uniprot/G3RGW7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:FCF1 ^@ http://purl.uniprot.org/uniprot/G3RJM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP23/FCF1 family. FCF1 subfamily.|||nucleolus http://togogenome.org/gene/9595:MUSK ^@ http://purl.uniprot.org/uniprot/A0A2I2YYW2|||http://purl.uniprot.org/uniprot/G3RHZ7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:KIF23 ^@ http://purl.uniprot.org/uniprot/A0A2I2YC58|||http://purl.uniprot.org/uniprot/G3QN02 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9595:RGS9BP ^@ http://purl.uniprot.org/uniprot/A0A2I2YKW4 ^@ Similarity ^@ Belongs to the RGS7BP/RGS9BP family. http://togogenome.org/gene/9595:SEMA6C ^@ http://purl.uniprot.org/uniprot/G3S1I2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:TOR2A ^@ http://purl.uniprot.org/uniprot/A0A2I2Y268|||http://purl.uniprot.org/uniprot/G3R628 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ClpA/ClpB family. Torsin subfamily.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9595:NECAP1 ^@ http://purl.uniprot.org/uniprot/G3R403 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NECAP family.|||Involved in endocytosis.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9595:TLR10 ^@ http://purl.uniprot.org/uniprot/G3S396 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9595:FERMT2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y2T0|||http://purl.uniprot.org/uniprot/A0A2I2YNQ6 ^@ Similarity ^@ Belongs to the kindlin family. http://togogenome.org/gene/9595:MGRN1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YL88|||http://purl.uniprot.org/uniprot/A0A2I2ZPB0 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin ligase. http://togogenome.org/gene/9595:CNOT8 ^@ http://purl.uniprot.org/uniprot/A0A2I2YK27|||http://purl.uniprot.org/uniprot/G3R4J4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/9595:USP22 ^@ http://purl.uniprot.org/uniprot/A0A2I2YU55 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9595:FAM163B ^@ http://purl.uniprot.org/uniprot/A0A2I2YUT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM163 family.|||Membrane http://togogenome.org/gene/9595:ADA ^@ http://purl.uniprot.org/uniprot/G3QVE6|||http://purl.uniprot.org/uniprot/G3SDQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.|||Cell junction|||Cell membrane|||Cytoplasmic vesicle lumen http://togogenome.org/gene/9595:PHPT1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZM03|||http://purl.uniprot.org/uniprot/G3RFK7 ^@ Function|||Similarity ^@ Belongs to the janus family.|||Exhibits phosphohistidine phosphatase activity. http://togogenome.org/gene/9595:EIF3K ^@ http://purl.uniprot.org/uniprot/A0A2I2ZVW5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit K family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with CCND3, but not with CCND1 and CCND2.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:HM13 ^@ http://purl.uniprot.org/uniprot/G3QFB0|||http://purl.uniprot.org/uniprot/G3S6U2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A22B family.|||Membrane http://togogenome.org/gene/9595:LOC101138643 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y664 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:B4GALT3 ^@ http://purl.uniprot.org/uniprot/G3QX18 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9595:ZDHHC15 ^@ http://purl.uniprot.org/uniprot/A0A2I2YGP2|||http://purl.uniprot.org/uniprot/G3S7L3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9595:RAD50 ^@ http://purl.uniprot.org/uniprot/G3QFG8 ^@ Similarity ^@ Belongs to the SMC family. RAD50 subfamily. http://togogenome.org/gene/9595:SFN ^@ http://purl.uniprot.org/uniprot/G3R777 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9595:TSPAN12 ^@ http://purl.uniprot.org/uniprot/G3SKI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9595:BOLA3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZZ20 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/9595:UBE2D1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YMV6 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9595:RPS6 ^@ http://purl.uniprot.org/uniprot/G3QJL6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/9595:RIBC2 ^@ http://purl.uniprot.org/uniprot/G3QH71 ^@ Similarity ^@ Belongs to the RIB43A family. http://togogenome.org/gene/9595:ACAD8 ^@ http://purl.uniprot.org/uniprot/G3QVA8 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9595:MED6 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z7F9|||http://purl.uniprot.org/uniprot/A0A2I2ZB28 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 6 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9595:LOC109028795 ^@ http://purl.uniprot.org/uniprot/G3S6N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:SNRPD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YB48 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP core protein family.|||Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Component of the minor spliceosome, which splices U12-type introns. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP. Interacts (via C-terminus) with SMN1 (via Tudor domain); the interaction is direct. Interacts with GEMIN2; the interaction is direct. Interacts with SNRPD2; the interaction is direct.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.|||cytosol http://togogenome.org/gene/9595:NOL6 ^@ http://purl.uniprot.org/uniprot/G3QN23 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NRAP family.|||Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.|||nucleolus http://togogenome.org/gene/9595:TMEM106B ^@ http://purl.uniprot.org/uniprot/A0A2I2ZVK7 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/9595:GK5 ^@ http://purl.uniprot.org/uniprot/G3QM69 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/9595:PLA2G4F ^@ http://purl.uniprot.org/uniprot/G3S105 ^@ Domain|||Subcellular Location Annotation ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding.|||cytosol http://togogenome.org/gene/9595:CDH8 ^@ http://purl.uniprot.org/uniprot/G3S1A0 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:MYADM ^@ http://purl.uniprot.org/uniprot/A0A2I2ZYW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAL family.|||Membrane http://togogenome.org/gene/9595:CCS ^@ http://purl.uniprot.org/uniprot/G3R2G0 ^@ Similarity ^@ In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family. http://togogenome.org/gene/9595:PIPOX ^@ http://purl.uniprot.org/uniprot/G3R9I2 ^@ Similarity ^@ Belongs to the MSOX/MTOX family. http://togogenome.org/gene/9595:CASK ^@ http://purl.uniprot.org/uniprot/A0A2I2Z2B4|||http://purl.uniprot.org/uniprot/A0A2I2ZHQ2|||http://purl.uniprot.org/uniprot/G3QXT0 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/9595:PLCB2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z4L6|||http://purl.uniprot.org/uniprot/G3QEQ0 ^@ Cofactor|||Function ^@ Binds 1 Ca(2+) ion per subunit.|||The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. http://togogenome.org/gene/9595:TAS2R4 ^@ http://purl.uniprot.org/uniprot/Q645Y8 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity). In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity).|||Membrane|||Several bitter taste receptors are expressed in a single taste receptor cell.|||cilium membrane http://togogenome.org/gene/9595:SLC5A5 ^@ http://purl.uniprot.org/uniprot/G3QS13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:NQO1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZYE4|||http://purl.uniprot.org/uniprot/G3QL89 ^@ Similarity ^@ Belongs to the NAD(P)H dehydrogenase (quinone) family. http://togogenome.org/gene/9595:LCLAT1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z6V6 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9595:HSF2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y5N3|||http://purl.uniprot.org/uniprot/G3SFM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/9595:F2RL3 ^@ http://purl.uniprot.org/uniprot/G3QXM5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:HSD17B2 ^@ http://purl.uniprot.org/uniprot/G3RKG6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9595:HTR4 ^@ http://purl.uniprot.org/uniprot/G3RJU9|||http://purl.uniprot.org/uniprot/G3RNJ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Endosome|||Membrane|||This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. http://togogenome.org/gene/9595:MRPS30 ^@ http://purl.uniprot.org/uniprot/G3RJ29 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9595:MINAR2 ^@ http://purl.uniprot.org/uniprot/G3RUQ4 ^@ Similarity ^@ Belongs to the MINAR family. http://togogenome.org/gene/9595:SHOX2 ^@ http://purl.uniprot.org/uniprot/G3R7K9|||http://purl.uniprot.org/uniprot/G3RNS2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:GPR4 ^@ http://purl.uniprot.org/uniprot/A0A2I2YZ13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:DLC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YYR9|||http://purl.uniprot.org/uniprot/G3S9H8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:GGCX ^@ http://purl.uniprot.org/uniprot/G3QQH6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:ALKBH3 ^@ http://purl.uniprot.org/uniprot/G3QHR7 ^@ Similarity ^@ Belongs to the alkB family. http://togogenome.org/gene/9595:SNX20 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z817 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome membrane|||Membrane http://togogenome.org/gene/9595:SLC43A2 ^@ http://purl.uniprot.org/uniprot/G3RS89 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:RPL26L1 ^@ http://purl.uniprot.org/uniprot/G3RTN1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/9595:MEIS2 ^@ http://purl.uniprot.org/uniprot/G3S663 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/9595:NECAP2 ^@ http://purl.uniprot.org/uniprot/G3RDX4|||http://purl.uniprot.org/uniprot/G3RX69 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NECAP family.|||Involved in endocytosis.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9595:ALDH16A1 ^@ http://purl.uniprot.org/uniprot/G3R3R3 ^@ Similarity|||Subunit ^@ Belongs to the aldehyde dehydrogenase family.|||Interacts with SPG21. http://togogenome.org/gene/9595:GLYATL3 ^@ http://purl.uniprot.org/uniprot/G3S0M6 ^@ Similarity ^@ Belongs to the glycine N-acyltransferase family. http://togogenome.org/gene/9595:INSM2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1D2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:SGCD ^@ http://purl.uniprot.org/uniprot/G3QYJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/9595:CALHM4 ^@ http://purl.uniprot.org/uniprot/A0A2I2YWW7|||http://purl.uniprot.org/uniprot/G3RLR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9595:TSPAN14 ^@ http://purl.uniprot.org/uniprot/A0A2I2YKV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9595:CDC25B ^@ http://purl.uniprot.org/uniprot/G3R749|||http://purl.uniprot.org/uniprot/G3SBV4 ^@ Function|||Similarity ^@ Belongs to the MPI phosphatase family.|||Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. http://togogenome.org/gene/9595:RIN1 ^@ http://purl.uniprot.org/uniprot/G3R4P0 ^@ Similarity ^@ Belongs to the RIN (Ras interaction/interference) family. http://togogenome.org/gene/9595:PIK3CA ^@ http://purl.uniprot.org/uniprot/G3R1S6 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9595:PDGFRB ^@ http://purl.uniprot.org/uniprot/G3QWE1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Cytoplasmic vesicle|||Interacts with homodimeric PDGFB and PDGFD, and with heterodimers formed by PDGFA and PDGFB.|||Lysosome lumen|||Membrane|||Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.|||Vesicle http://togogenome.org/gene/9595:PCMTD2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YGK4|||http://purl.uniprot.org/uniprot/G3SKP0 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/9595:MRPL3 ^@ http://purl.uniprot.org/uniprot/G3SD27 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/9595:TNFSF13B ^@ http://purl.uniprot.org/uniprot/G3RM11 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9595:DCTD ^@ http://purl.uniprot.org/uniprot/G3RJW1 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/9595:DARS2 ^@ http://purl.uniprot.org/uniprot/G3RQA7 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. http://togogenome.org/gene/9595:ASIC4 ^@ http://purl.uniprot.org/uniprot/G3QJT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.|||Membrane http://togogenome.org/gene/9595:ASB3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZE80|||http://purl.uniprot.org/uniprot/G3QE45 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9595:TAS2R39 ^@ http://purl.uniprot.org/uniprot/G3RZB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9595:CDCA2 ^@ http://purl.uniprot.org/uniprot/G3S128 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:PREB ^@ http://purl.uniprot.org/uniprot/A0A2I2YHJ9|||http://purl.uniprot.org/uniprot/G3RWQ4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat SEC12 family.|||Endoplasmic reticulum membrane|||Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.|||Interacts with SAR1B (GDP-bound form). Interacts with MIA2; recruits PREB to endoplasmic reticulum exit sites.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription. http://togogenome.org/gene/9595:LOC101153294 ^@ http://purl.uniprot.org/uniprot/G3QY66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:SRRD ^@ http://purl.uniprot.org/uniprot/G3QQM6 ^@ Similarity ^@ Belongs to the SRR1 family. http://togogenome.org/gene/9595:HTR5A ^@ http://purl.uniprot.org/uniprot/G3RHM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:NDEL1 ^@ http://purl.uniprot.org/uniprot/G3RDB5|||http://purl.uniprot.org/uniprot/G3S5K6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nudE family.|||centrosome|||kinetochore|||spindle http://togogenome.org/gene/9595:FUNDC1 ^@ http://purl.uniprot.org/uniprot/G3SEG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FUN14 family.|||Mitochondrion outer membrane http://togogenome.org/gene/9595:C5H5orf24 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZP93 ^@ Similarity ^@ Belongs to the UPF0461 family. http://togogenome.org/gene/9595:MTNR1B ^@ http://purl.uniprot.org/uniprot/G3RDH2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.|||Membrane http://togogenome.org/gene/9595:KALRN ^@ http://purl.uniprot.org/uniprot/A0A2I2Z083|||http://purl.uniprot.org/uniprot/G3QGW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.|||Cytoplasm http://togogenome.org/gene/9595:HOMER3 ^@ http://purl.uniprot.org/uniprot/G3RT61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Homer family.|||Cytoplasm|||Postsynaptic density|||Synapse http://togogenome.org/gene/9595:LOC109028100 ^@ http://purl.uniprot.org/uniprot/G3R3F3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:NEMP2 ^@ http://purl.uniprot.org/uniprot/G3RIH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NEMP family.|||Nucleus inner membrane http://togogenome.org/gene/9595:HIBADH ^@ http://purl.uniprot.org/uniprot/G3RBS7 ^@ Similarity ^@ Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily. http://togogenome.org/gene/9595:UBE2H ^@ http://purl.uniprot.org/uniprot/A0A2I2YHS9 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9595:ARL6IP5 ^@ http://purl.uniprot.org/uniprot/G3QFA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/9595:CACNG1 ^@ http://purl.uniprot.org/uniprot/G3RAI4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.|||sarcolemma http://togogenome.org/gene/9595:GABPA ^@ http://purl.uniprot.org/uniprot/G3RDF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9595:STX16 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y315 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9595:LOC101144146 ^@ http://purl.uniprot.org/uniprot/Q2QD07 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homodimer.|||It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.|||Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. http://togogenome.org/gene/9595:SPATS2 ^@ http://purl.uniprot.org/uniprot/G3SIH8 ^@ Similarity ^@ Belongs to the SPATS2 family. http://togogenome.org/gene/9595:PAIP2 ^@ http://purl.uniprot.org/uniprot/G3S5H7 ^@ Similarity ^@ Belongs to the PAIP2 family. http://togogenome.org/gene/9595:WTAP ^@ http://purl.uniprot.org/uniprot/A0A2I2Z8M3|||http://purl.uniprot.org/uniprot/G3QT98 ^@ Similarity ^@ Belongs to the fl(2)d family. http://togogenome.org/gene/9595:TUBA1C ^@ http://purl.uniprot.org/uniprot/A0A2I2ZN22 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9595:KCNK13 ^@ http://purl.uniprot.org/uniprot/G3QYK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9595:H1-5 ^@ http://purl.uniprot.org/uniprot/G3QGG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9595:ATP1B4 ^@ http://purl.uniprot.org/uniprot/G3RTJ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9595:TSPAN7 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z7S8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9595:DCLK2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YMA6|||http://purl.uniprot.org/uniprot/G3RDR8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9595:KLHL21 ^@ http://purl.uniprot.org/uniprot/G3QVB9 ^@ Subcellular Location Annotation ^@ spindle http://togogenome.org/gene/9595:ASB8 ^@ http://purl.uniprot.org/uniprot/G3QUD1 ^@ Function|||Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family.|||May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/9595:MGMT ^@ http://purl.uniprot.org/uniprot/G3RKK1 ^@ Function|||Similarity ^@ Belongs to the MGMT family.|||Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. http://togogenome.org/gene/9595:TOP3B ^@ http://purl.uniprot.org/uniprot/G3S8S1 ^@ Function|||Similarity ^@ Belongs to the type IA topoisomerase family.|||Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. http://togogenome.org/gene/9595:UBL3 ^@ http://purl.uniprot.org/uniprot/G3RUC3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:POFUT2 ^@ http://purl.uniprot.org/uniprot/G3RGF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 68 family.|||Endoplasmic reticulum http://togogenome.org/gene/9595:RSPH3 ^@ http://purl.uniprot.org/uniprot/G3QMQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the flagellar radial spoke RSP3 family.|||flagellum axoneme http://togogenome.org/gene/9595:KCNJ8 ^@ http://purl.uniprot.org/uniprot/G3R0Q9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9595:MASTL ^@ http://purl.uniprot.org/uniprot/G3RKT0 ^@ Subcellular Location Annotation ^@ Nucleus|||centrosome http://togogenome.org/gene/9595:POLR1A ^@ http://purl.uniprot.org/uniprot/G3QHD8 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta' chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/9595:SOHLH1 ^@ http://purl.uniprot.org/uniprot/G3QXY2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:S1PR1 ^@ http://purl.uniprot.org/uniprot/G3SKC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:EDN1 ^@ http://purl.uniprot.org/uniprot/G3RBV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Secreted http://togogenome.org/gene/9595:KLHL40 ^@ http://purl.uniprot.org/uniprot/G3QTF3 ^@ Similarity|||Subcellular Location Annotation ^@ A band|||Belongs to the KLHL40 family.|||I band http://togogenome.org/gene/9595:PSMA3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YTJ4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9595:MSANTD7 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZFK4 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9595:OVCA2 ^@ http://purl.uniprot.org/uniprot/G3R1S1 ^@ Similarity ^@ Belongs to the LovG family. http://togogenome.org/gene/9595:DPEP3 ^@ http://purl.uniprot.org/uniprot/G3RA55 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:APLP2 ^@ http://purl.uniprot.org/uniprot/G3R2X8|||http://purl.uniprot.org/uniprot/G3RU73 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APP family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:SPP2 ^@ http://purl.uniprot.org/uniprot/G3QUX2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPP2 family.|||Could coordinate an aspect of bone turnover.|||Secreted http://togogenome.org/gene/9595:ACTL10 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z9K7 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9595:PYY ^@ http://purl.uniprot.org/uniprot/G3R0I9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Secreted http://togogenome.org/gene/9595:CAMK1D ^@ http://purl.uniprot.org/uniprot/G3RK85 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:MESD ^@ http://purl.uniprot.org/uniprot/G3SH61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MESD family.|||Endoplasmic reticulum http://togogenome.org/gene/9595:KCNB2 ^@ http://purl.uniprot.org/uniprot/G3QL66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.|||Cell membrane|||Membrane|||Perikaryon|||dendrite http://togogenome.org/gene/9595:SLC16A10 ^@ http://purl.uniprot.org/uniprot/G3R8F1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:MRPL52 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1I3|||http://purl.uniprot.org/uniprot/G3QH07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL52 family.|||Mitochondrion http://togogenome.org/gene/9595:SLC27A1 ^@ http://purl.uniprot.org/uniprot/G3QQK0 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9595:SLC11A2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZA56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NRAMP family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/9595:DOCK7 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y2I8|||http://purl.uniprot.org/uniprot/A0A2I2ZJD2|||http://purl.uniprot.org/uniprot/G3QK73|||http://purl.uniprot.org/uniprot/G3S0Q6 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9595:NPRL3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZQL9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway.|||Belongs to the NPR3 family.|||Lysosome http://togogenome.org/gene/9595:PLD3 ^@ http://purl.uniprot.org/uniprot/G3R604 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/9595:RPL27A ^@ http://purl.uniprot.org/uniprot/G3QH17 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/9595:SMR3A ^@ http://purl.uniprot.org/uniprot/G3REQ8 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9595:CASQ1 ^@ http://purl.uniprot.org/uniprot/G3RFB8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calsequestrin family.|||Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.|||Sarcoplasmic reticulum lumen http://togogenome.org/gene/9595:RNF112 ^@ http://purl.uniprot.org/uniprot/G3QFE4 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9595:PRKCA ^@ http://purl.uniprot.org/uniprot/G3RIN3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.|||Cell membrane|||Cytoplasm|||Membrane|||Mitochondrion membrane|||Nucleus http://togogenome.org/gene/9595:DUSP9 ^@ http://purl.uniprot.org/uniprot/G3RGY6 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9595:KRT71 ^@ http://purl.uniprot.org/uniprot/G3QKU5 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:TLCD4 ^@ http://purl.uniprot.org/uniprot/G3S2Y8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:SLC7A3 ^@ http://purl.uniprot.org/uniprot/G3QFM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:CPM ^@ http://purl.uniprot.org/uniprot/G3QFY3 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9595:VPS16 ^@ http://purl.uniprot.org/uniprot/G3RJ59 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS16 family.|||Early endosome|||Late endosome membrane|||Lysosome membrane|||Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.|||Vesicle http://togogenome.org/gene/9595:SLC9A2 ^@ http://purl.uniprot.org/uniprot/G3RK34 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Interacts with CHP1 and CHP2.|||Membrane http://togogenome.org/gene/9595:PSMG1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZNL7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PSMG1 family.|||Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.|||Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2.|||Cytoplasm|||Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits.|||Forms a heterodimer with psmg2. http://togogenome.org/gene/9595:SLC4A7 ^@ http://purl.uniprot.org/uniprot/A0A2I2YZ27|||http://purl.uniprot.org/uniprot/G3R6J9 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9595:SEMA4B ^@ http://purl.uniprot.org/uniprot/A0A2I2YH96 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:YWHAH ^@ http://purl.uniprot.org/uniprot/G3QTE1 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9595:SLITRK1 ^@ http://purl.uniprot.org/uniprot/G3S5N8 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9595:AMHR2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZGP1|||http://purl.uniprot.org/uniprot/G3RA34 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane|||On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. http://togogenome.org/gene/9595:LOC101146257 ^@ http://purl.uniprot.org/uniprot/G3QTP1 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9595:IK ^@ http://purl.uniprot.org/uniprot/G3RC30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RED family.|||Nucleus http://togogenome.org/gene/9595:NSMCE2 ^@ http://purl.uniprot.org/uniprot/G3QYQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NSE2 family.|||Nucleus http://togogenome.org/gene/9595:PIAS3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YFU1|||http://purl.uniprot.org/uniprot/G3QWF6 ^@ Similarity ^@ Belongs to the PIAS family. http://togogenome.org/gene/9595:CNIH3 ^@ http://purl.uniprot.org/uniprot/G3QDC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/9595:MCTP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z7K2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:RGN ^@ http://purl.uniprot.org/uniprot/G3SBV7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMP-30/CGR1 family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9595:COQ2 ^@ http://purl.uniprot.org/uniprot/G3QM22 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family.|||Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis. Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl donor (such as all-trans-decaprenyl diphosphate or trans-nonaprenyl diphosphate). The length of the polyprenyl side chain varies depending on the species, in humans, the side chain is comprised of 10 isoprenyls producing CoQ10 (also known as ubiquinone), whereas rodents predominantly generate CoQ9. However, this specificity is not complete, human tissues have low amounts of CoQ9 and rodent organs contain some CoQ10. CoQs are vital molecules that transport electrons from mitochondrial respiratory chain complexes. CoQs also function as cofactors for uncoupling protein and play a role as regulators of the extracellularly-induced ceramide-dependent apoptotic pathway. Regulates mitochondrial permeability transition pore (mPTP) opening and ROS production (pivotal events in cell death) in a tissue specific manner.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:GJB2 ^@ http://purl.uniprot.org/uniprot/Q8MHW5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A hemichannel or connexon is composed of a hexamer of connexins. A functional gap junction is formed by the apposition of two hemichannels (By similarity). Forms heteromeric channels with GJB4. Interacts with CNST (By similarity).|||Belongs to the connexin family. Beta-type (group I) subfamily.|||Cell membrane|||Structural component of gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore.|||gap junction http://togogenome.org/gene/9595:MARCO ^@ http://purl.uniprot.org/uniprot/G3RHS7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:SUPT4H1 ^@ http://purl.uniprot.org/uniprot/G3QWC0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT4 family.|||Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.|||Nucleus http://togogenome.org/gene/9595:LOC101149676 ^@ http://purl.uniprot.org/uniprot/G3QUY7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:MEA1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YBP6|||http://purl.uniprot.org/uniprot/G3QWF2 ^@ Function ^@ May play an important role in spermatogenesis and/or testis development. http://togogenome.org/gene/9595:PPFIBP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YK59|||http://purl.uniprot.org/uniprot/A0A2I2ZFC2 ^@ Similarity ^@ Belongs to the liprin family. Liprin-beta subfamily. http://togogenome.org/gene/9595:WNK3 ^@ http://purl.uniprot.org/uniprot/G3R7G3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. http://togogenome.org/gene/9595:GABARAP ^@ http://purl.uniprot.org/uniprot/G3RD36 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9595:YIPF6 ^@ http://purl.uniprot.org/uniprot/A0A2I2YKX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:ELL3 ^@ http://purl.uniprot.org/uniprot/G3RBP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Nucleus http://togogenome.org/gene/9595:SEMA6D ^@ http://purl.uniprot.org/uniprot/A0A2I2YBL3|||http://purl.uniprot.org/uniprot/G3RK95 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:LGR6 ^@ http://purl.uniprot.org/uniprot/G3QSR1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:PDE7B ^@ http://purl.uniprot.org/uniprot/G3REW8|||http://purl.uniprot.org/uniprot/G3S185 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9595:ADRM1 ^@ http://purl.uniprot.org/uniprot/G3QZF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADRM1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:LOC101124039 ^@ http://purl.uniprot.org/uniprot/G3R178 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:PPP4R2 ^@ http://purl.uniprot.org/uniprot/G3QZA9 ^@ Similarity ^@ Belongs to the PPP4R2 family. http://togogenome.org/gene/9595:HOXC8 ^@ http://purl.uniprot.org/uniprot/G3QTW1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:FAM91A1 ^@ http://purl.uniprot.org/uniprot/G3RUG9 ^@ Similarity ^@ Belongs to the FAM91 family. http://togogenome.org/gene/9595:ASB2 ^@ http://purl.uniprot.org/uniprot/G3RHC1 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9595:RAB38 ^@ http://purl.uniprot.org/uniprot/G3RZI5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/9595:UBE2D3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z6N8|||http://purl.uniprot.org/uniprot/G3QG99 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9595:EFHC1 ^@ http://purl.uniprot.org/uniprot/G3S6D8 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9595:OPTN ^@ http://purl.uniprot.org/uniprot/A0A2I2ZQA1 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Golgi apparatus|||May act by regulating membrane trafficking and cellular morphogenesis.|||Recycling endosome|||autophagosome|||perinuclear region|||trans-Golgi network http://togogenome.org/gene/9595:ADORA2B ^@ http://purl.uniprot.org/uniprot/G3QH04 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. http://togogenome.org/gene/9595:SH3YL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZRD2|||http://purl.uniprot.org/uniprot/G3QF02 ^@ Similarity|||Subunit ^@ Belongs to the SH3YL1 family.|||Interacts with SH3D19. http://togogenome.org/gene/9595:GPHB5 ^@ http://purl.uniprot.org/uniprot/G3QW18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/9595:WFDC5 ^@ http://purl.uniprot.org/uniprot/A4K2R4 ^@ Function|||Subcellular Location Annotation ^@ Putative acid-stable proteinase inhibitor.|||Secreted http://togogenome.org/gene/9595:CFAP36 ^@ http://purl.uniprot.org/uniprot/G3QJP5 ^@ Similarity ^@ Belongs to the CFAP36 family. http://togogenome.org/gene/9595:OST4 ^@ http://purl.uniprot.org/uniprot/A0A2I2YHI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:ALDH1L1 ^@ http://purl.uniprot.org/uniprot/G3QQ24 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family.|||In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.|||In the N-terminal section; belongs to the GART family. http://togogenome.org/gene/9595:NUDT21 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZSS7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family. CPSF5 subfamily.|||Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.|||Cytoplasm|||Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.|||Nucleus http://togogenome.org/gene/9595:SPEN ^@ http://purl.uniprot.org/uniprot/G3R8N9 ^@ Similarity ^@ Belongs to the RRM Spen family. http://togogenome.org/gene/9595:TSPYL1 ^@ http://purl.uniprot.org/uniprot/G3RKQ2 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9595:ETFRF1 ^@ http://purl.uniprot.org/uniprot/G3QZR1 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9595:CDK5 ^@ http://purl.uniprot.org/uniprot/G3RL35 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:FNIP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YM43|||http://purl.uniprot.org/uniprot/A0A2I2ZT35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNIP family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9595:MRFAP1L1 ^@ http://purl.uniprot.org/uniprot/G3RMU4 ^@ Similarity ^@ Belongs to the MORF4 family-associated protein family. http://togogenome.org/gene/9595:GK ^@ http://purl.uniprot.org/uniprot/A0A2I2Z5A3|||http://purl.uniprot.org/uniprot/A0A2I2ZJI3|||http://purl.uniprot.org/uniprot/A0A2I2ZR50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FGGY kinase family.|||Cytoplasm http://togogenome.org/gene/9595:BEST4 ^@ http://purl.uniprot.org/uniprot/G3QS90 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms calcium-sensitive chloride channels. Permeable to bicarbonate.|||Membrane http://togogenome.org/gene/9595:MMUT ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1V9 ^@ Function|||Similarity ^@ Belongs to the methylmalonyl-CoA mutase family.|||Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle. http://togogenome.org/gene/9595:LIN7A ^@ http://purl.uniprot.org/uniprot/A0A2I2YLC3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the lin-7 family.|||Cell membrane|||Lateral cell membrane|||Membrane|||Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.|||Postsynaptic density membrane|||tight junction http://togogenome.org/gene/9595:BMP2 ^@ http://purl.uniprot.org/uniprot/G3RZN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/9595:PLA2G1B ^@ http://purl.uniprot.org/uniprot/G3QUX4 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9595:HGD ^@ http://purl.uniprot.org/uniprot/G3R0Y8 ^@ Similarity ^@ Belongs to the homogentisate dioxygenase family. http://togogenome.org/gene/9595:CNEP1R1 ^@ http://purl.uniprot.org/uniprot/G3RU62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNEP1R1 family.|||Cytoplasm|||Membrane|||Nucleus membrane http://togogenome.org/gene/9595:CCDC188 ^@ http://purl.uniprot.org/uniprot/G3SKC5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:NADK2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z7B5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAD kinase family.|||Homodimer.|||Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.|||Mitochondrion http://togogenome.org/gene/9595:HSD17B7 ^@ http://purl.uniprot.org/uniprot/G3R6M4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily. http://togogenome.org/gene/9595:TCL1A ^@ http://purl.uniprot.org/uniprot/G3QN55 ^@ Similarity ^@ Belongs to the TCL1 family. http://togogenome.org/gene/9595:LOC101148181 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZXC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Membrane http://togogenome.org/gene/9595:GDF6 ^@ http://purl.uniprot.org/uniprot/G3RVU6 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9595:AKAP8 ^@ http://purl.uniprot.org/uniprot/G3RC79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AKAP95 family.|||Nucleus matrix http://togogenome.org/gene/9595:FGF2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YE38 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9595:DPP3 ^@ http://purl.uniprot.org/uniprot/G3RM62 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M49 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9595:ADGRL2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z070|||http://purl.uniprot.org/uniprot/A0A2I2ZX12 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:MALL ^@ http://purl.uniprot.org/uniprot/A0A2I2YY30 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:KRT17 ^@ http://purl.uniprot.org/uniprot/G3RAM5 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:COQ7 ^@ http://purl.uniprot.org/uniprot/A0A2I2YCU9|||http://purl.uniprot.org/uniprot/G3QJN6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ7 family.|||Binds 2 iron ions per subunit.|||Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:RRP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z3L0 ^@ Similarity ^@ Belongs to the RRP1 family. http://togogenome.org/gene/9595:NME9 ^@ http://purl.uniprot.org/uniprot/A0A2I2YW59 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9595:PXN ^@ http://purl.uniprot.org/uniprot/A0A2I2ZNY8|||http://purl.uniprot.org/uniprot/G3S494 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paxillin family.|||cell cortex|||cytoskeleton|||focal adhesion http://togogenome.org/gene/9595:SLC27A4 ^@ http://purl.uniprot.org/uniprot/G3RFR1 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9595:PAX5 ^@ http://purl.uniprot.org/uniprot/G3RPN4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:YWHAB ^@ http://purl.uniprot.org/uniprot/G3QPJ3 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9595:GPRC5D ^@ http://purl.uniprot.org/uniprot/G3QF01 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:CCND3 ^@ http://purl.uniprot.org/uniprot/G3RGP1 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9595:ABCB8 ^@ http://purl.uniprot.org/uniprot/G3RL18 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:HIBCH ^@ http://purl.uniprot.org/uniprot/A0A2I2Z7M5|||http://purl.uniprot.org/uniprot/A0A2I2ZTG9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.|||Mitochondrion http://togogenome.org/gene/9595:ITM2C ^@ http://purl.uniprot.org/uniprot/G3QII8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITM2 family.|||Membrane http://togogenome.org/gene/9595:YPEL4 ^@ http://purl.uniprot.org/uniprot/G3RY61 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9595:CCKBR ^@ http://purl.uniprot.org/uniprot/A0A2I2Y4Q3|||http://purl.uniprot.org/uniprot/G3QWH4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9595:CACFD1 ^@ http://purl.uniprot.org/uniprot/G3RA05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel flower family.|||Membrane http://togogenome.org/gene/9595:TMED2 ^@ http://purl.uniprot.org/uniprot/G3SGK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9595:INTS10 ^@ http://purl.uniprot.org/uniprot/G3RVH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 10 family.|||Nucleus http://togogenome.org/gene/9595:LYZL4 ^@ http://purl.uniprot.org/uniprot/G3RHB9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9595:SERPINA7 ^@ http://purl.uniprot.org/uniprot/G3RVV8 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9595:CLSTN1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZCM8|||http://purl.uniprot.org/uniprot/G3SG87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calsyntenin family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Postsynaptic cell membrane http://togogenome.org/gene/9595:THAP1 ^@ http://purl.uniprot.org/uniprot/G3SK76 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the THAP1 family.|||DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.|||Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.|||nucleoplasm http://togogenome.org/gene/9595:PTPN14 ^@ http://purl.uniprot.org/uniprot/G3QF78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||cytoskeleton http://togogenome.org/gene/9595:MMRN1 ^@ http://purl.uniprot.org/uniprot/G3QX85 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:SGSM2 ^@ http://purl.uniprot.org/uniprot/G3QJ30|||http://purl.uniprot.org/uniprot/G3S4Y6 ^@ Similarity ^@ Belongs to the RUTBC family. http://togogenome.org/gene/9595:MDH2 ^@ http://purl.uniprot.org/uniprot/G3R803 ^@ Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 1 family.|||Homodimer. http://togogenome.org/gene/9595:EYA3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YTG5|||http://purl.uniprot.org/uniprot/G3S1I3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/9595:GPR180 ^@ http://purl.uniprot.org/uniprot/G3RVJ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:STK11 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZPN0|||http://purl.uniprot.org/uniprot/G3R625 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily. http://togogenome.org/gene/9595:XKR8 ^@ http://purl.uniprot.org/uniprot/G3RG17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9595:SLC17A2 ^@ http://purl.uniprot.org/uniprot/G3R8V3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:RITA1 ^@ http://purl.uniprot.org/uniprot/G3R4H5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RITA family.|||Cytoplasm|||Interacts with RBPJ/RBPSUH.|||Nucleus|||Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis. http://togogenome.org/gene/9595:TMEM167A ^@ http://purl.uniprot.org/uniprot/A0A2I2YI11 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KISH family.|||Golgi apparatus membrane|||Involved in the early part of the secretory pathway.|||Membrane http://togogenome.org/gene/9595:ATP10A ^@ http://purl.uniprot.org/uniprot/G3QHC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9595:ACSL1 ^@ http://purl.uniprot.org/uniprot/G3R3B2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.|||Endoplasmic reticulum membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9595:ADGRF5 ^@ http://purl.uniprot.org/uniprot/G3QYW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Membrane http://togogenome.org/gene/9595:ACTR6 ^@ http://purl.uniprot.org/uniprot/G3QEY5 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9595:FAM124B ^@ http://purl.uniprot.org/uniprot/G3QFD1 ^@ Similarity ^@ Belongs to the FAM124 family. http://togogenome.org/gene/9595:GLDC ^@ http://purl.uniprot.org/uniprot/A0A2I2Y3V0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvP family.|||Mitochondrion|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/9595:LAMTOR2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z8G4|||http://purl.uniprot.org/uniprot/G3QVA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GAMAD family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/9595:THRSP ^@ http://purl.uniprot.org/uniprot/G3QM60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPOT14 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:THNSL1 ^@ http://purl.uniprot.org/uniprot/G3RN04 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/9595:DYNLL1 ^@ http://purl.uniprot.org/uniprot/G3RUT1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.|||Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/9595:SEPTIN12 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZWR5|||http://purl.uniprot.org/uniprot/G3QX38 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9595:GPN2 ^@ http://purl.uniprot.org/uniprot/G3RH09 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/9595:DDX24 ^@ http://purl.uniprot.org/uniprot/G3QV31 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9595:CLUL1 ^@ http://purl.uniprot.org/uniprot/G3QG57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clusterin family.|||Secreted http://togogenome.org/gene/9595:MTMR4 ^@ http://purl.uniprot.org/uniprot/G3RD67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/9595:SMIM14 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZXD4 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9595:DLK2 ^@ http://purl.uniprot.org/uniprot/G3QZU4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:C2 ^@ http://purl.uniprot.org/uniprot/G3S5M5 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9595:MAPRE2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YQH5|||http://purl.uniprot.org/uniprot/G3S415 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||cytoskeleton http://togogenome.org/gene/9595:ITGA4 ^@ http://purl.uniprot.org/uniprot/G3S3M3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9595:LIPM ^@ http://purl.uniprot.org/uniprot/G3QWK0 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9595:HOXB13 ^@ http://purl.uniprot.org/uniprot/G3QHS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9595:PRKG2 ^@ http://purl.uniprot.org/uniprot/G3QUQ5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily. http://togogenome.org/gene/9595:IMMP1L ^@ http://purl.uniprot.org/uniprot/G3RG04 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26 family.|||Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.|||Heterodimer of 2 subunits, IMMPL1 and IMMPL2.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:TM7SF2 ^@ http://purl.uniprot.org/uniprot/G3QJR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Membrane http://togogenome.org/gene/9595:NFKB1 ^@ http://purl.uniprot.org/uniprot/G3RSI9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9595:APRT ^@ http://purl.uniprot.org/uniprot/G3RA66 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.|||Cytoplasm http://togogenome.org/gene/9595:ACAA2 ^@ http://purl.uniprot.org/uniprot/G3RA00 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/9595:TEFM ^@ http://purl.uniprot.org/uniprot/G3RXU1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TEFM family.|||Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery.|||mitochondrion nucleoid http://togogenome.org/gene/9595:MAB21L1 ^@ http://purl.uniprot.org/uniprot/G3R7X7 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9595:SLC46A2 ^@ http://purl.uniprot.org/uniprot/G3QNM0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:SLC6A17 ^@ http://purl.uniprot.org/uniprot/G3RBF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9595:NTS ^@ http://purl.uniprot.org/uniprot/G3R405 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurotensin family.|||Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.|||Secreted|||Vesicle|||secretory vesicle http://togogenome.org/gene/9595:KCNAB3 ^@ http://purl.uniprot.org/uniprot/G3QUA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shaker potassium channel beta subunit family.|||Cytoplasm http://togogenome.org/gene/9595:DYNC1I1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y567|||http://purl.uniprot.org/uniprot/G3QDB5 ^@ Similarity ^@ Belongs to the dynein intermediate chain family. http://togogenome.org/gene/9595:HS3ST2 ^@ http://purl.uniprot.org/uniprot/G3RFC1 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9595:KLRK1 ^@ http://purl.uniprot.org/uniprot/G3QVM2 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9595:IL26 ^@ http://purl.uniprot.org/uniprot/G3R6F4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/9595:PRMT5 ^@ http://purl.uniprot.org/uniprot/A0A2I2YIS9|||http://purl.uniprot.org/uniprot/G3R5J7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).|||Belongs to the class I-like SAM-binding methyltransferase superfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:ATRX ^@ http://purl.uniprot.org/uniprot/A0A2I2YRM7|||http://purl.uniprot.org/uniprot/A0A2I2Z161 ^@ Subcellular Location Annotation ^@ Nucleus|||telomere http://togogenome.org/gene/9595:LOC101136203 ^@ http://purl.uniprot.org/uniprot/G3RNS3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:KDM1A ^@ http://purl.uniprot.org/uniprot/G3S4L3|||http://purl.uniprot.org/uniprot/G3SBH6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the flavin monoamine oxidase family.|||Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity.|||Nucleus|||The SWIRM domain may act as an anchor site for a histone tail. http://togogenome.org/gene/9595:DNAJC27 ^@ http://purl.uniprot.org/uniprot/G3QN94 ^@ Function|||Subunit ^@ GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.|||Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms). http://togogenome.org/gene/9595:TM6SF1 ^@ http://purl.uniprot.org/uniprot/G3RGB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TM6SF family.|||Membrane http://togogenome.org/gene/9595:RAB9A ^@ http://purl.uniprot.org/uniprot/G3SA04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||phagosome membrane http://togogenome.org/gene/9595:TMEM258 ^@ http://purl.uniprot.org/uniprot/G3R9Z6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST5 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/9595:SPPL2A ^@ http://purl.uniprot.org/uniprot/G3RBH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A22B family.|||Endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9595:PLTP ^@ http://purl.uniprot.org/uniprot/G3RIP6 ^@ Similarity ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. http://togogenome.org/gene/9595:TRPC3 ^@ http://purl.uniprot.org/uniprot/G3QPH6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:RPF1 ^@ http://purl.uniprot.org/uniprot/G3RIH1 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9595:SLC22A3 ^@ http://purl.uniprot.org/uniprot/G3QHT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:CCT5 ^@ http://purl.uniprot.org/uniprot/G3SG70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9595:TEX261 ^@ http://purl.uniprot.org/uniprot/G3R299 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SVP26 family.|||Membrane http://togogenome.org/gene/9595:GADD45B ^@ http://purl.uniprot.org/uniprot/G3S1I1 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/9595:SIKE1 ^@ http://purl.uniprot.org/uniprot/G3RHY2 ^@ Similarity ^@ Belongs to the SIKE family. http://togogenome.org/gene/9595:NEUROD6 ^@ http://purl.uniprot.org/uniprot/G3SJZ7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:HAT1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZE90 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HAT1 family.|||Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.|||Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac). http://togogenome.org/gene/9595:IMP3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZCU7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/9595:PEPD ^@ http://purl.uniprot.org/uniprot/G3R8Y2 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/9595:LOC101135980 ^@ http://purl.uniprot.org/uniprot/G3R2C5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9595:NT5C3A ^@ http://purl.uniprot.org/uniprot/A0A2I2ZQ04|||http://purl.uniprot.org/uniprot/G3S3P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrimidine 5'-nucleotidase family.|||Cytoplasm http://togogenome.org/gene/9595:S100A9 ^@ http://purl.uniprot.org/uniprot/G3QEY7 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9595:POMC ^@ http://purl.uniprot.org/uniprot/G3QLQ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.|||Belongs to the POMC family.|||Endogenous opiate.|||Endogenous orexigenic opiate.|||Secreted|||Stimulates the adrenal glands to release cortisol. http://togogenome.org/gene/9595:HTR1E ^@ http://purl.uniprot.org/uniprot/G3SG67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:PPA2 ^@ http://purl.uniprot.org/uniprot/G3RSM6 ^@ Similarity ^@ Belongs to the PPase family. http://togogenome.org/gene/9595:RAD51 ^@ http://purl.uniprot.org/uniprot/A0A2I2YW66 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Nucleus|||Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair. http://togogenome.org/gene/9595:B2M ^@ http://purl.uniprot.org/uniprot/P61771 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta-2-microglobulin family.|||Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).|||Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules (By similarity).|||Secreted http://togogenome.org/gene/9595:ABCB10 ^@ http://purl.uniprot.org/uniprot/G3S798 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:OPN4 ^@ http://purl.uniprot.org/uniprot/G3RVR8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:LY6G5C ^@ http://purl.uniprot.org/uniprot/G3R3A3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Forms oligomers.|||May have a role in hematopoietic cell differentiation.|||Secreted http://togogenome.org/gene/9595:PSMB7 ^@ http://purl.uniprot.org/uniprot/G3R8Z6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:SMIM8 ^@ http://purl.uniprot.org/uniprot/G3QJE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM8 family.|||Membrane http://togogenome.org/gene/9595:UHRF2 ^@ http://purl.uniprot.org/uniprot/G3R0H3 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications.|||Nucleus|||The YDG domain mediates the interaction with histone H3.|||The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3). http://togogenome.org/gene/9595:NAMPT ^@ http://purl.uniprot.org/uniprot/A0A2I2Z4X6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAPRTase family.|||Cytoplasm|||Homodimer.|||Nucleus|||Secreted http://togogenome.org/gene/9595:SLFN5 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZFU0 ^@ Similarity ^@ Belongs to the Schlafen family. Subgroup III subfamily. http://togogenome.org/gene/9595:TFAP2D ^@ http://purl.uniprot.org/uniprot/G3QLT1 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/9595:TMEM50A ^@ http://purl.uniprot.org/uniprot/G3R938 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane http://togogenome.org/gene/9595:DEFB126 ^@ http://purl.uniprot.org/uniprot/A0A2I2YWV9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9595:NDUFA13 ^@ http://purl.uniprot.org/uniprot/Q0MQ89 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.|||Belongs to the complex I NDUFA13 subunit family.|||Complex I is composed of 45 different subunits. Interacts with CARD15, but not with CARD4. Interacts with STAT3, but not with STAT1, STAT2 and STAT5A. Interacts with OLFM4.|||Mitochondrion inner membrane|||Nucleus http://togogenome.org/gene/9595:SLC14A1 ^@ http://purl.uniprot.org/uniprot/G3QYN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urea transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:FAAH2 ^@ http://purl.uniprot.org/uniprot/G3SJZ0 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/9595:PIGS ^@ http://purl.uniprot.org/uniprot/G3R2L5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGS family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:LOC101152665 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZVH1 ^@ Similarity ^@ Belongs to the SPIN/STSY family. http://togogenome.org/gene/9595:ACTR1A ^@ http://purl.uniprot.org/uniprot/G3QJD6 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9595:RHBDD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z389 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:RBM22 ^@ http://purl.uniprot.org/uniprot/G3RAZ8 ^@ Similarity ^@ Belongs to the SLT11 family. http://togogenome.org/gene/9595:SEC62 ^@ http://purl.uniprot.org/uniprot/G3RCU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC62 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:CDC42EP3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZB00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/9595:PGLYRP1 ^@ http://purl.uniprot.org/uniprot/G3R6A3 ^@ Function|||Similarity ^@ Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.|||Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. http://togogenome.org/gene/9595:NKX2-3 ^@ http://purl.uniprot.org/uniprot/G3S329 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:FOXA3 ^@ http://purl.uniprot.org/uniprot/G3QMZ7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:LOC101144905 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZTM6|||http://purl.uniprot.org/uniprot/G3QV01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Membrane http://togogenome.org/gene/9595:FGF11 ^@ http://purl.uniprot.org/uniprot/G3RYY2 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9595:CRY1 ^@ http://purl.uniprot.org/uniprot/G3S1D1 ^@ Cofactor|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/9595:SMR3B ^@ http://purl.uniprot.org/uniprot/G3R0L7 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9595:ITPK1 ^@ http://purl.uniprot.org/uniprot/G3QPH0 ^@ Similarity ^@ Belongs to the ITPK1 family. http://togogenome.org/gene/9595:PLCB1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y8M5|||http://purl.uniprot.org/uniprot/A0A2I2Z963 ^@ Cofactor|||Function ^@ Binds 1 Ca(2+) ion per subunit.|||The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. http://togogenome.org/gene/9595:HS3ST3A1 ^@ http://purl.uniprot.org/uniprot/G3RXI3 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9595:NMI ^@ http://purl.uniprot.org/uniprot/G3RCF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NMI family.|||Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/9595:ST6GAL1 ^@ http://purl.uniprot.org/uniprot/G3QUR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9595:STX11 ^@ http://purl.uniprot.org/uniprot/G3R6A4 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9595:DDR2 ^@ http://purl.uniprot.org/uniprot/G3R7H7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:AQP8 ^@ http://purl.uniprot.org/uniprot/G3R630 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9595:CDC37L1 ^@ http://purl.uniprot.org/uniprot/G3QVG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC37 family.|||Cytoplasm http://togogenome.org/gene/9595:CLDN8 ^@ http://purl.uniprot.org/uniprot/G3S7W7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9595:SLC25A29 ^@ http://purl.uniprot.org/uniprot/G3QPV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9595:AMACR ^@ http://purl.uniprot.org/uniprot/G3RWM7 ^@ Similarity ^@ Belongs to the CoA-transferase III family. http://togogenome.org/gene/9595:RABEP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZNI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rabaptin family.|||Cytoplasm|||Early endosome|||Endosome http://togogenome.org/gene/9595:FOXA2 ^@ http://purl.uniprot.org/uniprot/G3RYD0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:STXBP3 ^@ http://purl.uniprot.org/uniprot/G3QWA1 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9595:PCNX2 ^@ http://purl.uniprot.org/uniprot/G3SKS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pecanex family.|||Membrane http://togogenome.org/gene/9595:AHR ^@ http://purl.uniprot.org/uniprot/G3S4Z4 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9595:KRT12 ^@ http://purl.uniprot.org/uniprot/G3QNR7 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:IRF4 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZLK9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:ATP6V0C ^@ http://purl.uniprot.org/uniprot/G3RR62 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.|||Vacuole membrane|||clathrin-coated vesicle membrane|||synaptic vesicle membrane http://togogenome.org/gene/9595:LOC101153662 ^@ http://purl.uniprot.org/uniprot/G3QF15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:TNPO1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZPQ4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:HTR3B ^@ http://purl.uniprot.org/uniprot/G3QQV8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:GJB4 ^@ http://purl.uniprot.org/uniprot/G3R0R2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9595:F13A1 ^@ http://purl.uniprot.org/uniprot/G3QFU9 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9595:SKA1 ^@ http://purl.uniprot.org/uniprot/G3RKH3 ^@ Similarity ^@ Belongs to the SKA1 family. http://togogenome.org/gene/9595:GDF7 ^@ http://purl.uniprot.org/uniprot/G3QDB1 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9595:LOC101148806 ^@ http://purl.uniprot.org/uniprot/G3QEL1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9595:PRPS2 ^@ http://purl.uniprot.org/uniprot/G3QZ28 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family.|||Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.|||Homodimer. The active form is probably a hexamer composed of 3 homodimers. http://togogenome.org/gene/9595:TFPI2 ^@ http://purl.uniprot.org/uniprot/G3QPC8 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9595:SLC37A4 ^@ http://purl.uniprot.org/uniprot/G3QJL4|||http://purl.uniprot.org/uniprot/G3RSJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Membrane http://togogenome.org/gene/9595:INA ^@ http://purl.uniprot.org/uniprot/G3QK94 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:RTCA ^@ http://purl.uniprot.org/uniprot/G3R285|||http://purl.uniprot.org/uniprot/G3SGY2 ^@ Function|||Similarity ^@ Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.|||Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. http://togogenome.org/gene/9595:CALHM2 ^@ http://purl.uniprot.org/uniprot/G3R7M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9595:KRT19 ^@ http://purl.uniprot.org/uniprot/G3RL54 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:RNASEH2A ^@ http://purl.uniprot.org/uniprot/G3QSS9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the RNase HII family. Eukaryotic subfamily.|||Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/9595:LOC101124310 ^@ http://purl.uniprot.org/uniprot/G3QNF7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:LOC101154497 ^@ http://purl.uniprot.org/uniprot/G3S6R1 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9595:FREM3 ^@ http://purl.uniprot.org/uniprot/G3QZ62 ^@ Similarity ^@ Belongs to the FRAS1 family. http://togogenome.org/gene/9595:SLC9A5 ^@ http://purl.uniprot.org/uniprot/G3R3F7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Membrane|||Recycling endosome membrane http://togogenome.org/gene/9595:CPNE5 ^@ http://purl.uniprot.org/uniprot/G3QSK9 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9595:LOC101138909 ^@ http://purl.uniprot.org/uniprot/G3RFV2 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9595:TUBGCP6 ^@ http://purl.uniprot.org/uniprot/A0A2I2YK02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||centrosome http://togogenome.org/gene/9595:CPSF4 ^@ http://purl.uniprot.org/uniprot/G3RGL8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CPSF4/YTH1 family.|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex.|||Nucleus http://togogenome.org/gene/9595:TNK2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZJI1|||http://purl.uniprot.org/uniprot/G3R096|||http://purl.uniprot.org/uniprot/G3RVW0 ^@ Subcellular Location Annotation ^@ Membrane|||Nucleus http://togogenome.org/gene/9595:ATP1B2 ^@ http://purl.uniprot.org/uniprot/G3QJS3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9595:PIGO ^@ http://purl.uniprot.org/uniprot/G3QL12|||http://purl.uniprot.org/uniprot/G3S324 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:TUBG2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YLY1|||http://purl.uniprot.org/uniprot/A0A2I2ZF66 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin family.|||Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.|||centrosome http://togogenome.org/gene/9595:PLSCR1 ^@ http://purl.uniprot.org/uniprot/G3RTX1 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/9595:PRDX1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZDQ0 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/9595:EIF4EBP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZJX6 ^@ Similarity ^@ Belongs to the eIF4E-binding protein family. http://togogenome.org/gene/9595:ADGRG4 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z089 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:SPARC ^@ http://purl.uniprot.org/uniprot/G3RJ76 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.|||Belongs to the SPARC family.|||Membrane|||basement membrane http://togogenome.org/gene/9595:GDF9 ^@ http://purl.uniprot.org/uniprot/G3R9D6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.|||Secreted http://togogenome.org/gene/9595:LOC101123860 ^@ http://purl.uniprot.org/uniprot/G3RVL7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9595:APOA1 ^@ http://purl.uniprot.org/uniprot/G3QY98 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the apolipoprotein A1/A4/E family.|||Glycosylated.|||Homodimer (By similarity). Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1. Interacts with SCGB3A2 (By similarity). Interacts with NAXE and YJEFN3 (By similarity).|||Major protein of plasma HDL, also found in chylomicrons.|||Palmitoylated.|||Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).|||Phosphorylation sites are present in the extracellular medium.|||Secreted http://togogenome.org/gene/9595:ALKBH1 ^@ http://purl.uniprot.org/uniprot/G3R638 ^@ Cofactor|||Similarity ^@ Belongs to the alkB family.|||Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/9595:AK3 ^@ http://purl.uniprot.org/uniprot/G3S5H3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK3 subfamily.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.|||Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.|||Mitochondrion matrix|||Monomer. http://togogenome.org/gene/9595:ATPSCKMT ^@ http://purl.uniprot.org/uniprot/G3RDZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ANT/ATPSC lysine N-methyltransferase family.|||Mitochondrion membrane http://togogenome.org/gene/9595:NOP56 ^@ http://purl.uniprot.org/uniprot/G3QK68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP5/NOP56 family.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9595:ITGA5 ^@ http://purl.uniprot.org/uniprot/G3QEL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9595:SEMG2 ^@ http://purl.uniprot.org/uniprot/A4K2R8 ^@ Similarity ^@ Belongs to the semenogelin family. http://togogenome.org/gene/9595:PIK3C2G ^@ http://purl.uniprot.org/uniprot/A0A2I2Z7Z4 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9595:DRD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YZU4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.|||Membrane|||dendritic spine http://togogenome.org/gene/9595:VIL1 ^@ http://purl.uniprot.org/uniprot/G3REI7 ^@ Similarity ^@ Belongs to the villin/gelsolin family. http://togogenome.org/gene/9595:LOC101132777 ^@ http://purl.uniprot.org/uniprot/G3RIZ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COA3 family.|||Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.|||Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.|||Membrane|||Required for assembly of cytochrome c oxidase (complex IV). http://togogenome.org/gene/9595:NPTX2 ^@ http://purl.uniprot.org/uniprot/G3RFI7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9595:CLU ^@ http://purl.uniprot.org/uniprot/G3RL83 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Antiparallel disulfide-linked heterodimer of an alpha chain and a beta chain. Self-associates and forms higher oligomers.|||Belongs to the clusterin family.|||Endoplasmic reticulum|||Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.|||Membrane|||Microsome|||Mitochondrion membrane|||Nucleus|||Secreted|||chromaffin granule|||cytosol|||perinuclear region http://togogenome.org/gene/9595:NGFR ^@ http://purl.uniprot.org/uniprot/G3QZD4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:RPL31 ^@ http://purl.uniprot.org/uniprot/G3SDU2 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL31 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/9595:SEPTIN14 ^@ http://purl.uniprot.org/uniprot/G3RXM9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9595:ABCC8 ^@ http://purl.uniprot.org/uniprot/G3RIT5 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with KCNJ11.|||Membrane http://togogenome.org/gene/9595:LOC101130441 ^@ http://purl.uniprot.org/uniprot/G3REB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/9595:ENO2 ^@ http://purl.uniprot.org/uniprot/G3QS64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/9595:MT3 ^@ http://purl.uniprot.org/uniprot/G3QSV7 ^@ Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family. http://togogenome.org/gene/9595:BUD31 ^@ http://purl.uniprot.org/uniprot/G3RGK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BUD31 (G10) family.|||Nucleus http://togogenome.org/gene/9595:MAP1LC3A ^@ http://purl.uniprot.org/uniprot/A0A2I2YGZ5 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9595:LOC101152412 ^@ http://purl.uniprot.org/uniprot/Q0ZQL0 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization (By similarity). PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition (By similarity). Acetylation at Lys-125 favors the interaction with TARDBP (By similarity).|||Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.|||Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.|||Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity).|||Cytoplasm|||Interacts with protein phosphatase PPP3CA/calcineurin A (By similarity). Interacts with isoform 2 of BSG/CD147 (By similarity). Interacts with FOXO1; the interaction promotes FOXO1 dephosphorylation, nuclear accumulation and transcriptional activity (By similarity). Interacts with integrin ITGA2B:ITGB3; the interaction is ROS and peptidyl-prolyl cis-trans isomerase (PPIase) activity-dependent and is increased in the presence of thrombin (By similarity). Interacts with MAP3K5 (By similarity). Interacts with TARDBP; the interaction is dependent on the RNA-binding activity of TARDBP and the PPIase activity of PPIA/CYPA and the acetylation of PPIA/CYPA at Lys-125 favors the interaction (By similarity). Interacts with HNRNPA1, HNRNPA2B1, HNRNPC, RBMX, HNRNPK and HNRNPM (By similarity).|||Nucleus|||Secreted http://togogenome.org/gene/9595:TM9SF1 ^@ http://purl.uniprot.org/uniprot/G3RJ16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/9595:LOC101132106 ^@ http://purl.uniprot.org/uniprot/G3QUH1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:LIF ^@ http://purl.uniprot.org/uniprot/G3SIT4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LIF/OSM family.|||LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.|||Secreted http://togogenome.org/gene/9595:FGF8 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z6C8|||http://purl.uniprot.org/uniprot/G3RGJ3 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9595:KCNV2 ^@ http://purl.uniprot.org/uniprot/G3QDB6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:CDC42SE2 ^@ http://purl.uniprot.org/uniprot/G3R8P0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CDC42SE/SPEC family.|||Cell membrane|||Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.|||Membrane|||Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.|||cytoskeleton http://togogenome.org/gene/9595:TEX13A ^@ http://purl.uniprot.org/uniprot/G3QMH3 ^@ Similarity ^@ Belongs to the TEX13 family. http://togogenome.org/gene/9595:BIRC2 ^@ http://purl.uniprot.org/uniprot/G3QZ38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IAP family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:TRIM32 ^@ http://purl.uniprot.org/uniprot/G3RQW7 ^@ Similarity ^@ Belongs to the TRIM/RBCC family. http://togogenome.org/gene/9595:G6PD ^@ http://purl.uniprot.org/uniprot/G3RMM2 ^@ Function|||Similarity ^@ Belongs to the glucose-6-phosphate dehydrogenase family.|||Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. http://togogenome.org/gene/9595:PLB1 ^@ http://purl.uniprot.org/uniprot/G3RKZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:MYRF ^@ http://purl.uniprot.org/uniprot/G3R9Y7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRF family.|||Membrane http://togogenome.org/gene/9595:AKIRIN2 ^@ http://purl.uniprot.org/uniprot/G3QJ27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus http://togogenome.org/gene/9595:SLC25A40 ^@ http://purl.uniprot.org/uniprot/G3QPT0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:COPZ2 ^@ http://purl.uniprot.org/uniprot/G3SHB6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes small subunit family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. http://togogenome.org/gene/9595:DGAT2L6 ^@ http://purl.uniprot.org/uniprot/G3QG27 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:TTC3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YT81 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:SPIB ^@ http://purl.uniprot.org/uniprot/A0A2I2ZKX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9595:RNF145 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z3K5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:STMN4 ^@ http://purl.uniprot.org/uniprot/G3QLD5|||http://purl.uniprot.org/uniprot/G3SAS9 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/9595:B3GNT4 ^@ http://purl.uniprot.org/uniprot/G3RLN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:LYZ ^@ http://purl.uniprot.org/uniprot/P79179 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the glycosyl hydrolase 22 family.|||Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.|||Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.|||Monomer. http://togogenome.org/gene/9595:SPNS3 ^@ http://purl.uniprot.org/uniprot/G3QU46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.|||Membrane http://togogenome.org/gene/9595:ALDH5A1 ^@ http://purl.uniprot.org/uniprot/Q6A2H1 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aldehyde dehydrogenase family.|||Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).|||Homotetramer.|||Mitochondrion|||Redox-regulated. Inhibited under oxydizing conditions (By similarity). http://togogenome.org/gene/9595:SIX1 ^@ http://purl.uniprot.org/uniprot/A1YER0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SIX/Sine oculis homeobox family.|||Cytoplasm|||Interacts with DACH1 (By similarity). Interacts with EYA1 (By similarity). Interacts with EYA2 (By similarity). Interacts with CDH1 (By similarity). Interacts with TBX18 (By similarity). Interacts with CEBPA (By similarity). Interacts with CEBPB (By similarity). Interacts with EBF2 (By similarity).|||Nucleus|||Phosphorylated during interphase; becomes hyperphosphorylated during mitosis. Hyperphosphorylation impairs binding to promoter elements (By similarity).|||Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development (By similarity). Plays an important role in the development of several organs, including kidney, muscle and inner ear (By similarity). Depending on context, functions as transcriptional repressor or activator (By similarity). Lacks an activation domain, and requires interaction with EYA family members for transcription activation (By similarity). Mediates nuclear translocation of EYA1 and EYA2 (By similarity). Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter and CIDEA enhancer (By similarity). Regulates the expression of numerous genes, including MYC, CCNA1, CCND1 and EZR (By similarity). Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2 (By similarity). Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex (By similarity). During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1 (By similarity). Promotes brown adipocyte differentiation (By similarity).|||Ubiquitinated by the anaphase promoting complex (APC), leading to its proteasomal degradation. http://togogenome.org/gene/9595:HTR2B ^@ http://purl.uniprot.org/uniprot/G3RUA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||synaptosome http://togogenome.org/gene/9595:STING1 ^@ http://purl.uniprot.org/uniprot/G3RJ95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STING family.|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Mitochondrion outer membrane|||autophagosome membrane|||perinuclear region http://togogenome.org/gene/9595:DCBLD2 ^@ http://purl.uniprot.org/uniprot/G3R422 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:RPL29 ^@ http://purl.uniprot.org/uniprot/G3RTN2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL29 family. http://togogenome.org/gene/9595:PSAP ^@ http://purl.uniprot.org/uniprot/G3S0G3 ^@ Function|||Subcellular Location Annotation ^@ Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.|||Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.|||Secreted http://togogenome.org/gene/9595:NAT2 ^@ http://purl.uniprot.org/uniprot/A0A4P8J5B1|||http://purl.uniprot.org/uniprot/G3QP61 ^@ Similarity ^@ Belongs to the arylamine N-acetyltransferase family. http://togogenome.org/gene/9595:EXOC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YXC6|||http://purl.uniprot.org/uniprot/G3RNH4 ^@ Similarity ^@ Belongs to the SEC3 family. http://togogenome.org/gene/9595:CELF2 ^@ http://purl.uniprot.org/uniprot/G3RVT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CELF/BRUNOL family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:ARRDC3 ^@ http://purl.uniprot.org/uniprot/G3QNT9 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9595:GPAT4 ^@ http://purl.uniprot.org/uniprot/G3RIX8 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9595:KAT7 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZH11|||http://purl.uniprot.org/uniprot/G3SCG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/9595:RARG ^@ http://purl.uniprot.org/uniprot/A0A2I2ZFD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9595:FXYD5 ^@ http://purl.uniprot.org/uniprot/G3QRA9 ^@ Similarity ^@ Belongs to the FXYD family. http://togogenome.org/gene/9595:RNASE4 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y5W7 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9595:MRPL10 ^@ http://purl.uniprot.org/uniprot/G3RH60 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL10 family. http://togogenome.org/gene/9595:CXCR1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YD99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:TACC2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YEK5|||http://purl.uniprot.org/uniprot/A0A2I2YUL0|||http://purl.uniprot.org/uniprot/A0A2I2Z1F5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACC family.|||centrosome http://togogenome.org/gene/9595:LOC101131106 ^@ http://purl.uniprot.org/uniprot/Q69BK4 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Rieske iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster per subunit. Fe-S cluster delivery to the Rieske protein is mediated by components of the iron sulfur (Fe-S) cluster assembly machinery that reside in the mitochondrial matrix (including HSC20 and LYRM7) (By similarity).|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Incorporation of the Rieske protein UQCRFS1 is the penultimate step in complex III assembly. Interacts with TTC19, which is involved in the clearance of UQCRFS1 fragments (By similarity).|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII). Subunit 9 corresponds to the mitochondrial targeting sequence (MTS) of Rieske protein UQCRFS1. It is retained after processing and incorporated inside complex III, where it remains bound to the complex and localizes between the 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII). UQCRFS1 undergoes proteolytic processing once it is incorporated in the complex III dimer. One of the fragments, called subunit 9, corresponds to its mitochondrial targeting sequence (MTS) (By similarity). The proteolytic processing is necessary for the correct insertion of UQCRFS1 in the complex III dimer, but the persistence of UQCRFS1-derived fragments may prevent newly imported UQCRFS1 to be processed and assembled into complex III and is detrimental for the complex III structure and function (By similarity).|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. The Rieske protein is a catalytic core subunit containing a [2Fe-2S] iron-sulfur cluster. It cycles between 2 conformational states during catalysis to transfer electrons from the quinol bound in the Q(0) site in cytochrome b to cytochrome c1 (By similarity). Incorporation of UQCRFS1 is the penultimate step in complex III assembly (By similarity).|||Mitochondrion inner membrane|||Proteolytic processing is necessary for the correct insertion of UQCRFS1 in the complex III dimer. Several fragments are generated during UQCRFS1 insertion, most probably due to the endogenous matrix-processing peptidase (MPP) activity of the 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, which are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively. The action of the protease is also necessary for the clearance of the UQCRFS1 fragments.|||Several peptides are generated during UQCRFS1 insertion. According to some authors, the identification of the transit peptide as the subunit 9, does not necessary imply that it must be considered as a structural subunit of the complex III dimer as additional fragments from UQCRFS1 are also present.|||The Rieske protein is a high potential 2Fe-2S protein. http://togogenome.org/gene/9595:HEPHL1 ^@ http://purl.uniprot.org/uniprot/G3SBH1 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/9595:PTP4A2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZXM0 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9595:GSKIP ^@ http://purl.uniprot.org/uniprot/G3RMZ0 ^@ Similarity ^@ Belongs to the GSKIP family. http://togogenome.org/gene/9595:ARHGDIB ^@ http://purl.uniprot.org/uniprot/G3R1T1 ^@ Similarity ^@ Belongs to the Rho GDI family. http://togogenome.org/gene/9595:FABP2 ^@ http://purl.uniprot.org/uniprot/G3S5C9 ^@ Function|||Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor. http://togogenome.org/gene/9595:LOC101134753 ^@ http://purl.uniprot.org/uniprot/G3R122 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:GRHPR ^@ http://purl.uniprot.org/uniprot/G3QMB0 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/9595:PROKR1 ^@ http://purl.uniprot.org/uniprot/G3RJH8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:CYSLTR2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZRR0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:TMEM59 ^@ http://purl.uniprot.org/uniprot/G3QY76|||http://purl.uniprot.org/uniprot/G3S6B3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM59 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:MIOS ^@ http://purl.uniprot.org/uniprot/G3QEE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat mio family.|||Lysosome membrane http://togogenome.org/gene/9595:NDUFS5 ^@ http://purl.uniprot.org/uniprot/Q0MQH3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS5 subunit family.|||Contains two C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds.|||Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/9595:TBXA2R ^@ http://purl.uniprot.org/uniprot/G3S6J9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:IL15 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z0S9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Secreted http://togogenome.org/gene/9595:SCGB2A2 ^@ http://purl.uniprot.org/uniprot/G3QU17 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9595:CSNK2B ^@ http://purl.uniprot.org/uniprot/A0A2I2Y5K6|||http://purl.uniprot.org/uniprot/G3QS09 ^@ Function|||Similarity|||Subunit ^@ Belongs to the casein kinase 2 subunit beta family.|||Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/9595:LOC101125738 ^@ http://purl.uniprot.org/uniprot/G3QKC7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9595:CDK9 ^@ http://purl.uniprot.org/uniprot/G3R636 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9595:SCAMP1 ^@ http://purl.uniprot.org/uniprot/G3RGR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/9595:UBE2D2 ^@ http://purl.uniprot.org/uniprot/G3RPB9 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9595:SNX4 ^@ http://purl.uniprot.org/uniprot/A0A2I2YW17 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9595:CFI ^@ http://purl.uniprot.org/uniprot/A0A2I2Y2K4|||http://purl.uniprot.org/uniprot/G3QLG4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:DEFB132 ^@ http://purl.uniprot.org/uniprot/A4H262 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9595:PATL1 ^@ http://purl.uniprot.org/uniprot/G3QNX6 ^@ Similarity ^@ Belongs to the PAT1 family. http://togogenome.org/gene/9595:ASB5 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z2E6 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9595:STMN2 ^@ http://purl.uniprot.org/uniprot/G3QQ25 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/9595:VIP ^@ http://purl.uniprot.org/uniprot/G3S8F4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/9595:EMSY ^@ http://purl.uniprot.org/uniprot/A0A2I2Y6S8|||http://purl.uniprot.org/uniprot/A0A2I2YKJ0|||http://purl.uniprot.org/uniprot/G3RAY4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:LUC7L3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YXZ3|||http://purl.uniprot.org/uniprot/A0A2I2ZKX8|||http://purl.uniprot.org/uniprot/G3S0S9 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/9595:HMGCR ^@ http://purl.uniprot.org/uniprot/G3R5R7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMG-CoA reductase family.|||Endoplasmic reticulum membrane|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9595:BCL9 ^@ http://purl.uniprot.org/uniprot/G3R1L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BCL9 family.|||Nucleus http://togogenome.org/gene/9595:WASHC3 ^@ http://purl.uniprot.org/uniprot/G3RG72 ^@ Similarity ^@ Belongs to the CCDC53 family. http://togogenome.org/gene/9595:LOC101152035 ^@ http://purl.uniprot.org/uniprot/G3SFC0 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/9595:OLFM4 ^@ http://purl.uniprot.org/uniprot/G3R975 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:KDM6A ^@ http://purl.uniprot.org/uniprot/A0A2I2ZWK4|||http://purl.uniprot.org/uniprot/G3QUS2|||http://purl.uniprot.org/uniprot/G3S4D8|||http://purl.uniprot.org/uniprot/G3S7I8|||http://purl.uniprot.org/uniprot/G3SJL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTX family.|||Nucleus http://togogenome.org/gene/9595:RAD23A ^@ http://purl.uniprot.org/uniprot/G3SC93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAD23 family.|||Cytoplasm|||Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.|||Nucleus http://togogenome.org/gene/9595:CABIN1 ^@ http://purl.uniprot.org/uniprot/G3SDU4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:IL17A ^@ http://purl.uniprot.org/uniprot/G3R2P6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/9595:ADAT2 ^@ http://purl.uniprot.org/uniprot/G3RJA0 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.|||Probably participates in deamination of adenosine-34 to inosine in many tRNAs. http://togogenome.org/gene/9595:SARM1 ^@ http://purl.uniprot.org/uniprot/G3R687 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SARM1 family.|||axon http://togogenome.org/gene/9595:NPY2R ^@ http://purl.uniprot.org/uniprot/G3RAX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:P3H3 ^@ http://purl.uniprot.org/uniprot/G3RTT2 ^@ Similarity ^@ Belongs to the leprecan family. http://togogenome.org/gene/9595:F5 ^@ http://purl.uniprot.org/uniprot/G3R571 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/9595:CTSE ^@ http://purl.uniprot.org/uniprot/A0A2I2ZKJ4|||http://purl.uniprot.org/uniprot/G3QES7 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/9595:RPL35A ^@ http://purl.uniprot.org/uniprot/G3RZ05 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL33 family. http://togogenome.org/gene/9595:FGF3 ^@ http://purl.uniprot.org/uniprot/G3RV80 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9595:B4GALT7 ^@ http://purl.uniprot.org/uniprot/A0A2I2YRF1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9595:RLN2 ^@ http://purl.uniprot.org/uniprot/G3RZY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.|||Secreted http://togogenome.org/gene/9595:TMEM11 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZS05 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM11 family.|||Membrane|||Plays a role in mitochondrial morphogenesis. http://togogenome.org/gene/9595:ADCY9 ^@ http://purl.uniprot.org/uniprot/G3QEG6 ^@ Similarity ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. http://togogenome.org/gene/9595:SATB2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z942 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/9595:ST7L ^@ http://purl.uniprot.org/uniprot/A0A2I2Y7D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ST7 family.|||Membrane http://togogenome.org/gene/9595:KIFBP ^@ http://purl.uniprot.org/uniprot/G3RAK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KIF-binding protein family.|||cytoskeleton http://togogenome.org/gene/9595:LOC101149907 ^@ http://purl.uniprot.org/uniprot/G3R1B6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:UBE2L3 ^@ http://purl.uniprot.org/uniprot/G3RVY8 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9595:SLC17A4 ^@ http://purl.uniprot.org/uniprot/G3QIG1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:LOC101151457 ^@ http://purl.uniprot.org/uniprot/G3QPD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-defensin family.|||Secreted http://togogenome.org/gene/9595:TFAP2C ^@ http://purl.uniprot.org/uniprot/G3QDT6 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/9595:LOC101132438 ^@ http://purl.uniprot.org/uniprot/G3QMI7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCR10/QCR9 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9595:ORM1 ^@ http://purl.uniprot.org/uniprot/G3RUF6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Functions as transport protein in the blood stream.|||Secreted http://togogenome.org/gene/9595:ELAC2 ^@ http://purl.uniprot.org/uniprot/Q9GL73 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase Z family.|||Homodimer. Interacts with PTCD1.|||Mitochondrion|||Nucleus|||Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly.|||mitochondrion nucleoid http://togogenome.org/gene/9595:SYNDIG1 ^@ http://purl.uniprot.org/uniprot/G3QEB6 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9595:TMEM43 ^@ http://purl.uniprot.org/uniprot/G3RKB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM43 family.|||Membrane http://togogenome.org/gene/9595:LOC101128883 ^@ http://purl.uniprot.org/uniprot/A0A2I2YL94 ^@ Similarity ^@ Belongs to the cornifin (SPRR) family. http://togogenome.org/gene/9595:LEFTY2 ^@ http://purl.uniprot.org/uniprot/G3QEZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/9595:ACER1 ^@ http://purl.uniprot.org/uniprot/G3R5N1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Membrane http://togogenome.org/gene/9595:DEFA5 ^@ http://purl.uniprot.org/uniprot/G3RJ35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-defensin family.|||Secreted http://togogenome.org/gene/9595:SPP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z8I2|||http://purl.uniprot.org/uniprot/G3QS39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the osteopontin family.|||Secreted http://togogenome.org/gene/9595:MYH8 ^@ http://purl.uniprot.org/uniprot/G3S8R0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9595:DOLPP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YEE7|||http://purl.uniprot.org/uniprot/G3QU69 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dolichyldiphosphatase family.|||Endoplasmic reticulum membrane|||Membrane|||Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate. http://togogenome.org/gene/9595:PTGER4 ^@ http://purl.uniprot.org/uniprot/G3QXC3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with FEM1A.|||Membrane|||Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. http://togogenome.org/gene/9595:ICAM2 ^@ http://purl.uniprot.org/uniprot/Q5NKV1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the immunoglobulin superfamily. ICAM family.|||ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance (By similarity).|||Interacts with RDX, EZR and MSN.|||Membrane|||microvillus http://togogenome.org/gene/9595:GPR108 ^@ http://purl.uniprot.org/uniprot/G3RBK1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:COQ9 ^@ http://purl.uniprot.org/uniprot/G3R9M1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COQ9 family.|||Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.|||Mitochondrion http://togogenome.org/gene/9595:CDC6 ^@ http://purl.uniprot.org/uniprot/G3RHJ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC6/cdc18 family.|||Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.|||Nucleus http://togogenome.org/gene/9595:FASLG ^@ http://purl.uniprot.org/uniprot/G3S9V6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tumor necrosis factor family.|||Cell membrane|||Cytoplasmic form induces gene transcription inhibition.|||Cytoplasmic vesicle lumen|||Lysosome lumen|||Nucleus|||Secreted http://togogenome.org/gene/9595:SLC12A6 ^@ http://purl.uniprot.org/uniprot/A0A2I2YSB0|||http://purl.uniprot.org/uniprot/A0A2I2Z741|||http://purl.uniprot.org/uniprot/A0A2I2ZT44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9595:TTC27 ^@ http://purl.uniprot.org/uniprot/G3RAF8 ^@ Similarity ^@ Belongs to the TTC27 family. http://togogenome.org/gene/9595:PPBP ^@ http://purl.uniprot.org/uniprot/G3RZ42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9595:DOCK1 ^@ http://purl.uniprot.org/uniprot/G3RGJ8 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9595:MRPL15 ^@ http://purl.uniprot.org/uniprot/G3R4E8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/9595:HCFC2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YK61 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:TRMT11 ^@ http://purl.uniprot.org/uniprot/G3RLG2 ^@ Function|||Subunit ^@ Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.|||Interacts with TRMT112. http://togogenome.org/gene/9595:SFRP4 ^@ http://purl.uniprot.org/uniprot/G3S0Y7 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:GFAP ^@ http://purl.uniprot.org/uniprot/G3RB64 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:RPS4X ^@ http://purl.uniprot.org/uniprot/G3RUZ2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/9595:PPM1G ^@ http://purl.uniprot.org/uniprot/G3R5Y7 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9595:LIN28B ^@ http://purl.uniprot.org/uniprot/G3RHE0 ^@ Similarity ^@ Belongs to the lin-28 family. http://togogenome.org/gene/9595:CLP1 ^@ http://purl.uniprot.org/uniprot/G3SDE3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Clp1 family. Clp1 subfamily.|||Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54. Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK.|||Nucleus|||Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing. http://togogenome.org/gene/9595:CYFIP2 ^@ http://purl.uniprot.org/uniprot/G3RM65|||http://purl.uniprot.org/uniprot/G3SAQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYFIP family.|||synaptosome http://togogenome.org/gene/9595:GBP4 ^@ http://purl.uniprot.org/uniprot/G3RC82 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9595:ARRDC5 ^@ http://purl.uniprot.org/uniprot/G3SH71 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9595:PPP1R21 ^@ http://purl.uniprot.org/uniprot/G3RJS6 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9595:RBFOX2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z2Y8 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||RNA-binding protein that regulates alternative splicing events. http://togogenome.org/gene/9595:ILK ^@ http://purl.uniprot.org/uniprot/G3QDQ9 ^@ Subcellular Location Annotation ^@ focal adhesion|||lamellipodium|||sarcomere http://togogenome.org/gene/9595:ELF5 ^@ http://purl.uniprot.org/uniprot/G3QVG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9595:SPATS2L ^@ http://purl.uniprot.org/uniprot/A0A2I2YBB9|||http://purl.uniprot.org/uniprot/G3QSZ3 ^@ Similarity ^@ Belongs to the SPATS2 family. http://togogenome.org/gene/9595:CTDP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZU92|||http://purl.uniprot.org/uniprot/G3R674 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||This promotes the activity of RNA polymerase II. http://togogenome.org/gene/9595:TAS1R1 ^@ http://purl.uniprot.org/uniprot/G3QVA2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9595:GATA2 ^@ http://purl.uniprot.org/uniprot/G3QTJ7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:MET ^@ http://purl.uniprot.org/uniprot/A0A2I2Z3S5|||http://purl.uniprot.org/uniprot/Q2IBF2 ^@ Activity Regulation|||Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Autophosphorylated in response to ligand binding on Tyr-1234 and Tyr-1235 in the kinase domain leading to further phosphorylation of Tyr-1349 and Tyr-1356 in the C-terminal multifunctional docking site. Dephosphorylated by PTPRJ at Tyr-1349 and Tyr-1365. Dephosphorylated by PTPN1 and PTPN2 (By similarity).|||Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Heterodimer made of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1. Interacts when phosphorylated with downstream effectors including STAT3, PIK3R1, SRC, PCLG1, GRB2 and GAB1. Interacts with SPSB1, SPSB2 and SPSB4. Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation. Interacts with GRB10. Interacts with PTPN1 and PTPN2. Interacts with HSP90AA1 and HSP90AB1; the interaction suppresses MET kinase activity. Interacts with tensin TNS3 (By similarity). Interacts (when phosphorylated) with tensin TNS4 (via SH2 domain); the interaction increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation (By similarity).|||In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity (By similarity).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||O-mannosylation of IPT/TIG domains by TMEM260 is required for protein maturation. O-mannosylated residues are composed of single mannose glycans that are not elongated or modified.|||Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity).|||The beta-propeller Sema domain mediates binding to HGF.|||The kinase domain is involved in SPSB1 binding.|||Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation (By similarity). http://togogenome.org/gene/9595:SUPT5H ^@ http://purl.uniprot.org/uniprot/G3RET7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT5 family.|||Nucleus http://togogenome.org/gene/9595:RGS9 ^@ http://purl.uniprot.org/uniprot/G3RHN0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:RAB3GAP1 ^@ http://purl.uniprot.org/uniprot/G3RGG4|||http://purl.uniprot.org/uniprot/G3SA53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab3-GAP catalytic subunit family.|||Cytoplasm|||Endoplasmic reticulum http://togogenome.org/gene/9595:IFRD1 ^@ http://purl.uniprot.org/uniprot/G3QEL0|||http://purl.uniprot.org/uniprot/G3S2A4 ^@ Similarity ^@ Belongs to the IFRD family. http://togogenome.org/gene/9595:UBE3D ^@ http://purl.uniprot.org/uniprot/G3RKB3 ^@ Function ^@ E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. http://togogenome.org/gene/9595:KRT84 ^@ http://purl.uniprot.org/uniprot/G3QJZ1 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:SCARB1 ^@ http://purl.uniprot.org/uniprot/G3QUG5 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/9595:ZNF326 ^@ http://purl.uniprot.org/uniprot/G3SAC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AKAP95 family.|||Nucleus matrix http://togogenome.org/gene/9595:RDM1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YDT7|||http://purl.uniprot.org/uniprot/G3R4V8 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Homodimer.|||nucleolus http://togogenome.org/gene/9595:RNASE2 ^@ http://purl.uniprot.org/uniprot/P47782 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pancreatic ribonuclease family.|||Cytoplasmic granule|||Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur (By similarity).|||Lysosome|||This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Possesses a wide variety of biological activities. http://togogenome.org/gene/9595:NIPSNAP1 ^@ http://purl.uniprot.org/uniprot/G3QMG9 ^@ Similarity ^@ Belongs to the NipSnap family. http://togogenome.org/gene/9595:LZTFL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YVN9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LZTFL1 family.|||Cytoplasm|||Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.|||Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking. http://togogenome.org/gene/9595:MANEA ^@ http://purl.uniprot.org/uniprot/A0A2I2ZQH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 99 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:VEPH1 ^@ http://purl.uniprot.org/uniprot/G3SKM2 ^@ Similarity ^@ Belongs to the MELT/VEPH family. http://togogenome.org/gene/9595:STAM ^@ http://purl.uniprot.org/uniprot/G3QDI4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the STAM family.|||Early endosome membrane|||Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. http://togogenome.org/gene/9595:OPRK1 ^@ http://purl.uniprot.org/uniprot/G3QEH7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.|||Interacts with NHERF1. Interacts with GABARAPL1.|||Membrane http://togogenome.org/gene/9595:GDF2 ^@ http://purl.uniprot.org/uniprot/G3QSX0 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9595:NXF1 ^@ http://purl.uniprot.org/uniprot/G3RPH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NXF family.|||Cytoplasm|||nucleoplasm http://togogenome.org/gene/9595:SLC46A1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YRU8|||http://purl.uniprot.org/uniprot/G3R696 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:GPR182 ^@ http://purl.uniprot.org/uniprot/G3RRX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ST6GALNAC3 ^@ http://purl.uniprot.org/uniprot/G3QGI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9595:LOC101151678 ^@ http://purl.uniprot.org/uniprot/G3S412 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9595:VPS18 ^@ http://purl.uniprot.org/uniprot/G3QKG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS18 family.|||Membrane http://togogenome.org/gene/9595:ILDR2 ^@ http://purl.uniprot.org/uniprot/G3QYQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. LISCH7 family.|||Membrane|||tight junction http://togogenome.org/gene/9595:ESR2 ^@ http://purl.uniprot.org/uniprot/A0A2I2YL00|||http://purl.uniprot.org/uniprot/G3QKK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/9595:MOV10 ^@ http://purl.uniprot.org/uniprot/G3QJU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.|||P-body http://togogenome.org/gene/9595:CCR4 ^@ http://purl.uniprot.org/uniprot/G3RC17 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:MON1B ^@ http://purl.uniprot.org/uniprot/G3S4E9 ^@ Function|||Similarity ^@ Belongs to the MON1/SAND family.|||Plays an important role in membrane trafficking through the secretory apparatus. http://togogenome.org/gene/9595:BORCS8 ^@ http://purl.uniprot.org/uniprot/G3RN26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS8 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9595:MRPS5 ^@ http://purl.uniprot.org/uniprot/G3QHA0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS5 family. http://togogenome.org/gene/9595:CBX1 ^@ http://purl.uniprot.org/uniprot/G3S830 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:PTGER2 ^@ http://purl.uniprot.org/uniprot/G3R8I2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:LOC101130073 ^@ http://purl.uniprot.org/uniprot/G3SBD8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:LPCAT3 ^@ http://purl.uniprot.org/uniprot/G3QNT5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:BIRC7 ^@ http://purl.uniprot.org/uniprot/G3QZ53 ^@ Similarity ^@ Belongs to the IAP family. http://togogenome.org/gene/9595:MKX ^@ http://purl.uniprot.org/uniprot/G3RJD8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:BEST1 ^@ http://purl.uniprot.org/uniprot/G3R6Z8|||http://purl.uniprot.org/uniprot/G3RQQ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms calcium-sensitive chloride channels. Permeable to bicarbonate.|||Membrane http://togogenome.org/gene/9595:ADPRM ^@ http://purl.uniprot.org/uniprot/G3R101 ^@ Similarity|||Subunit ^@ Belongs to the ADPRibase-Mn family.|||Monomer. http://togogenome.org/gene/9595:RELL2 ^@ http://purl.uniprot.org/uniprot/G3RJT5 ^@ Similarity ^@ Belongs to the RELT family. http://togogenome.org/gene/9595:FOXR1 ^@ http://purl.uniprot.org/uniprot/G3QFT0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:CHST10 ^@ http://purl.uniprot.org/uniprot/G3R7W3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9595:EEF1AKMT1 ^@ http://purl.uniprot.org/uniprot/G3RL82 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.|||Cytoplasm|||Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.|||Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure. http://togogenome.org/gene/9595:SLC25A25 ^@ http://purl.uniprot.org/uniprot/A0A2I2YDS2|||http://purl.uniprot.org/uniprot/G3RCW1|||http://purl.uniprot.org/uniprot/G3RSS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9595:LOXL3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZIZ8 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/9595:CTSL ^@ http://purl.uniprot.org/uniprot/G3SEM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9595:LOC101135431 ^@ http://purl.uniprot.org/uniprot/Q6WUX8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme c group covalently per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).|||Mitochondrion intermembrane space|||Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.|||Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity). http://togogenome.org/gene/9595:AURKB ^@ http://purl.uniprot.org/uniprot/G3QK52 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. http://togogenome.org/gene/9595:PIN4 ^@ http://purl.uniprot.org/uniprot/G3RIU6 ^@ Similarity ^@ Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily. http://togogenome.org/gene/9595:CRLS1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZEC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/9595:RO60 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y4R5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ro 60 kDa family.|||Cytoplasm http://togogenome.org/gene/9595:PRTFDC1 ^@ http://purl.uniprot.org/uniprot/G3RFK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/9595:C4BPA ^@ http://purl.uniprot.org/uniprot/G3R980 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:HSPB9 ^@ http://purl.uniprot.org/uniprot/G3QRU3 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/9595:LOC101151260 ^@ http://purl.uniprot.org/uniprot/G3QJY7 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9595:CACYBP ^@ http://purl.uniprot.org/uniprot/A0A2I2YIG0|||http://purl.uniprot.org/uniprot/A0A2I2Z4R9 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).|||Nucleus http://togogenome.org/gene/9595:VSX2 ^@ http://purl.uniprot.org/uniprot/G3QJF0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:ALG12 ^@ http://purl.uniprot.org/uniprot/G3QR58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:FOXP3 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z9W8|||http://purl.uniprot.org/uniprot/G3RR60 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:STXBP5 ^@ http://purl.uniprot.org/uniprot/G3RL45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat L(2)GL family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9595:PEA15 ^@ http://purl.uniprot.org/uniprot/G3RB66 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:SMIM19 ^@ http://purl.uniprot.org/uniprot/A0A2I2YNB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM19 family.|||Membrane http://togogenome.org/gene/9595:FRK ^@ http://purl.uniprot.org/uniprot/G3SKL2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9595:SNRNP200 ^@ http://purl.uniprot.org/uniprot/G3QR47 ^@ Similarity ^@ Belongs to the helicase family. SKI2 subfamily. http://togogenome.org/gene/9595:LOC109026990 ^@ http://purl.uniprot.org/uniprot/G3QK54 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL20 family. http://togogenome.org/gene/9595:TDRD7 ^@ http://purl.uniprot.org/uniprot/G3RGY8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TDRD7 family.|||Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.|||Cytoplasm|||Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex containing CABLES1, CDK16 and CDK17. Interacts with CABLES1, CDK17 and PIWIL1. http://togogenome.org/gene/9595:HEXIM2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z8E6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HEXIM family.|||Nucleus http://togogenome.org/gene/9595:SLC52A3 ^@ http://purl.uniprot.org/uniprot/G3QQS7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the riboflavin transporter family.|||Cell membrane|||Membrane|||Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. http://togogenome.org/gene/9595:PARD6B ^@ http://purl.uniprot.org/uniprot/G3R493 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAR6 family.|||Cytoplasm|||tight junction http://togogenome.org/gene/9595:CKAP2 ^@ http://purl.uniprot.org/uniprot/G3QT12 ^@ Similarity ^@ Belongs to the CKAP2 family. http://togogenome.org/gene/9595:ADAMTS6 ^@ http://purl.uniprot.org/uniprot/G3RJ61 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9595:SEMA3E ^@ http://purl.uniprot.org/uniprot/A0A2I2Y7L6 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:TTC21B ^@ http://purl.uniprot.org/uniprot/G3SFF5 ^@ Similarity ^@ Belongs to the TTC21 family. http://togogenome.org/gene/9595:ASF1A ^@ http://purl.uniprot.org/uniprot/G3R3I3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/9595:LOC101133388 ^@ http://purl.uniprot.org/uniprot/G3S3R3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9595:KIF20A ^@ http://purl.uniprot.org/uniprot/G3QW17 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9595:EME2 ^@ http://purl.uniprot.org/uniprot/G3QTS0 ^@ Similarity ^@ Belongs to the EME1/MMS4 family. http://togogenome.org/gene/9595:LOC101130358 ^@ http://purl.uniprot.org/uniprot/G3R5K4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9595:CCN1 ^@ http://purl.uniprot.org/uniprot/G3QVP6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9595:MPEG1 ^@ http://purl.uniprot.org/uniprot/G3R8Q4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MPEG1 family.|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/9595:SMARCA4 ^@ http://purl.uniprot.org/uniprot/G3R349 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/9595:EIF3M ^@ http://purl.uniprot.org/uniprot/A0A2I2ZIS0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Belongs to the eIF-3 subunit M family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm http://togogenome.org/gene/9595:CDH3 ^@ http://purl.uniprot.org/uniprot/G3QD40 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:VPS45 ^@ http://purl.uniprot.org/uniprot/G3SCA3 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9595:SNRPF ^@ http://purl.uniprot.org/uniprot/G3QFN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/9595:P2RX3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YYY7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9595:GJA8 ^@ http://purl.uniprot.org/uniprot/G3RX25 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9595:HYCC2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZIU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Hyccin family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/9595:LOC101150648 ^@ http://purl.uniprot.org/uniprot/G3RSQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:ZNF280B ^@ http://purl.uniprot.org/uniprot/G3QWZ1 ^@ Function|||Subcellular Location Annotation ^@ May function as a transcription factor.|||Nucleus http://togogenome.org/gene/9595:UBE2M ^@ http://purl.uniprot.org/uniprot/G3RC12 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9595:GFRA1 ^@ http://purl.uniprot.org/uniprot/G3QZP5|||http://purl.uniprot.org/uniprot/G3RQT9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.|||Belongs to the GDNFR family.|||Cell membrane|||Membrane|||Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. http://togogenome.org/gene/9595:CLTC ^@ http://purl.uniprot.org/uniprot/G3RZC8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin heavy chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||Membrane|||coated pit http://togogenome.org/gene/9595:MAU2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z2H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCC4/mau-2 family.|||nucleoplasm http://togogenome.org/gene/9595:FBLN7 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZS34 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:KCNJ2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z844 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.|||Membrane http://togogenome.org/gene/9595:AQP11 ^@ http://purl.uniprot.org/uniprot/G3R8H6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:C1H1orf43 ^@ http://purl.uniprot.org/uniprot/A0A2I2YQW7|||http://purl.uniprot.org/uniprot/A0A2I2ZYT0|||http://purl.uniprot.org/uniprot/G3S4N8 ^@ Function|||Subcellular Location Annotation ^@ General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.|||Golgi apparatus|||Membrane|||Mitochondrion http://togogenome.org/gene/9595:GOT2 ^@ http://purl.uniprot.org/uniprot/G3QSK6 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/9595:NDNF ^@ http://purl.uniprot.org/uniprot/G3QZV0 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9595:CD36 ^@ http://purl.uniprot.org/uniprot/G3QTG5 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/9595:VPS37C ^@ http://purl.uniprot.org/uniprot/G3RKU8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9595:CNOT3 ^@ http://purl.uniprot.org/uniprot/G3RB45 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT2/3/5 family.|||Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity.|||Nucleus|||P-body http://togogenome.org/gene/9595:PML ^@ http://purl.uniprot.org/uniprot/G3RFT2|||http://purl.uniprot.org/uniprot/G3RPM5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9595:TNFSF15 ^@ http://purl.uniprot.org/uniprot/G3R5G8 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9595:DUSP3 ^@ http://purl.uniprot.org/uniprot/G3SGS9 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/9595:PDGFC ^@ http://purl.uniprot.org/uniprot/G3QZW6 ^@ Caution|||Similarity ^@ Belongs to the PDGF/VEGF growth factor family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:COG4 ^@ http://purl.uniprot.org/uniprot/A0A2I2YQ75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG4 family.|||Golgi apparatus membrane http://togogenome.org/gene/9595:TACSTD2 ^@ http://purl.uniprot.org/uniprot/G3R8Z1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPCAM family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:VTA1 ^@ http://purl.uniprot.org/uniprot/G3RHM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTA1 family.|||Cytoplasm|||Endosome membrane|||Membrane http://togogenome.org/gene/9595:TMEM88B ^@ http://purl.uniprot.org/uniprot/A0A2I2YUP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM88 family.|||Membrane http://togogenome.org/gene/9595:KCNA10 ^@ http://purl.uniprot.org/uniprot/G3QZB3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:RSRP1 ^@ http://purl.uniprot.org/uniprot/G3QRH7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RSRP family.|||Nucleus|||Probably acts as a spliceosomal factor that contributes to spliceosome assembly and regulates the isoform switching of proteins such as PARP6. http://togogenome.org/gene/9595:CRYBB1 ^@ http://purl.uniprot.org/uniprot/G3RCS4 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9595:ATP5MC2 ^@ http://purl.uniprot.org/uniprot/G3RHY1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/9595:ARL2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y999|||http://purl.uniprot.org/uniprot/G3QRA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||centrosome http://togogenome.org/gene/9595:ATG7 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZVZ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG7 family.|||Cytoplasm|||E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress.|||Homodimer.|||Preautophagosomal structure http://togogenome.org/gene/9595:LRWD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YVC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRWD1 family.|||centrosome|||kinetochore|||telomere http://togogenome.org/gene/9595:DLL3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZIN7|||http://purl.uniprot.org/uniprot/G3REV8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9595:FDPS ^@ http://purl.uniprot.org/uniprot/G3QDS5 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9595:STMN1 ^@ http://purl.uniprot.org/uniprot/G3S1A3 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/9595:RAD1 ^@ http://purl.uniprot.org/uniprot/G3QNL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad1 family.|||Nucleus http://togogenome.org/gene/9595:LIPT1 ^@ http://purl.uniprot.org/uniprot/G3S0M5 ^@ Similarity ^@ Belongs to the LplA family. http://togogenome.org/gene/9595:MYOZ3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZHU7 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/9595:PER2 ^@ http://purl.uniprot.org/uniprot/G3QPG7 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9595:ZEB1 ^@ http://purl.uniprot.org/uniprot/G3R3L7 ^@ Similarity ^@ Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family. http://togogenome.org/gene/9595:XK ^@ http://purl.uniprot.org/uniprot/G3RIZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9595:SERPINB1 ^@ http://purl.uniprot.org/uniprot/G3QXP5 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9595:TFRC ^@ http://purl.uniprot.org/uniprot/G3QWC9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.|||Homodimer; disulfide-linked.|||Melanosome|||Membrane|||Stearoylated. http://togogenome.org/gene/9595:KCNK17 ^@ http://purl.uniprot.org/uniprot/A0A2I2YRF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9595:AMPD3 ^@ http://purl.uniprot.org/uniprot/G3RDR3 ^@ Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.|||Homotetramer. http://togogenome.org/gene/9595:SMPDL3A ^@ http://purl.uniprot.org/uniprot/G3S0A8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acid sphingomyelinase family.|||Binds 2 Zn(2+) per subunit.|||Secreted http://togogenome.org/gene/9595:NR0B2 ^@ http://purl.uniprot.org/uniprot/G3RH19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR0 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9595:XG ^@ http://purl.uniprot.org/uniprot/A0A2I2YU09|||http://purl.uniprot.org/uniprot/G3RFE6 ^@ Similarity ^@ Belongs to the CD99 family. http://togogenome.org/gene/9595:CLCN3 ^@ http://purl.uniprot.org/uniprot/A0A2I2YUJ8|||http://purl.uniprot.org/uniprot/A0A2I2ZTH4|||http://purl.uniprot.org/uniprot/G3REC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.|||Cell membrane|||Early endosome membrane|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9595:GPR18 ^@ http://purl.uniprot.org/uniprot/G3RI27 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:STRIP2 ^@ http://purl.uniprot.org/uniprot/G3RKX3 ^@ Similarity ^@ Belongs to the STRIP family. http://togogenome.org/gene/9595:TRAF1 ^@ http://purl.uniprot.org/uniprot/G3QIN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/9595:MRPL53 ^@ http://purl.uniprot.org/uniprot/G3QUG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL53 family.|||Mitochondrion http://togogenome.org/gene/9595:VPS25 ^@ http://purl.uniprot.org/uniprot/G3RIX9 ^@ Similarity ^@ Belongs to the VPS25 family. http://togogenome.org/gene/9595:TRIP12 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZCZ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPL family. K-HECT subfamily.|||E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins.|||nucleoplasm http://togogenome.org/gene/9595:LOC101127788 ^@ http://purl.uniprot.org/uniprot/A0A2I2YLJ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. http://togogenome.org/gene/9595:GRM7 ^@ http://purl.uniprot.org/uniprot/A0A2I2YDB8|||http://purl.uniprot.org/uniprot/G3SKH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:SLC6A11 ^@ http://purl.uniprot.org/uniprot/A0A2I2YL32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9595:TLR8 ^@ http://purl.uniprot.org/uniprot/G3R9E0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9595:FGF4 ^@ http://purl.uniprot.org/uniprot/G3R3L3 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9595:RFX3 ^@ http://purl.uniprot.org/uniprot/G3QMK1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:RECQL5 ^@ http://purl.uniprot.org/uniprot/G3R233 ^@ Similarity ^@ Belongs to the helicase family. RecQ subfamily. http://togogenome.org/gene/9595:IL17RC ^@ http://purl.uniprot.org/uniprot/A0A2I2ZB51|||http://purl.uniprot.org/uniprot/A0A2I2ZVL0|||http://purl.uniprot.org/uniprot/G3R905|||http://purl.uniprot.org/uniprot/G3SA01 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:EPGN ^@ http://purl.uniprot.org/uniprot/A0A2I2Y861 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9595:PCMTD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YGW6|||http://purl.uniprot.org/uniprot/G3S020 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/9595:LOC109025285 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z627 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Component of the 40S small ribosomal subunit. http://togogenome.org/gene/9595:ZDHHC14 ^@ http://purl.uniprot.org/uniprot/G3RAE6 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9595:CAMSAP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Y9P0|||http://purl.uniprot.org/uniprot/G3R5L5 ^@ Domain|||Similarity ^@ Belongs to the CAMSAP1 family.|||The CKK domain binds microtubules. http://togogenome.org/gene/9595:UPK1B ^@ http://purl.uniprot.org/uniprot/G3R766 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9595:SAP30 ^@ http://purl.uniprot.org/uniprot/G3QQV4 ^@ Similarity ^@ Belongs to the SAP30 family. http://togogenome.org/gene/9595:TAAR2 ^@ http://purl.uniprot.org/uniprot/G3RNT7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9595:RSL24D1 ^@ http://purl.uniprot.org/uniprot/G3QR54 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/9595:SEPTIN11 ^@ http://purl.uniprot.org/uniprot/G3RGK5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9595:DNAJC16 ^@ http://purl.uniprot.org/uniprot/G3QJH9 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Plays an important role in regulating the size of autophagosomes during the formation process. http://togogenome.org/gene/9595:CBR3 ^@ http://purl.uniprot.org/uniprot/G3REK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm http://togogenome.org/gene/9595:RPL17 ^@ http://purl.uniprot.org/uniprot/G3RX17 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/9595:NDUFB4 ^@ http://purl.uniprot.org/uniprot/Q0MQD4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB4 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9595:LOC101146324 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z9G0 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9595:DAND5 ^@ http://purl.uniprot.org/uniprot/A0A2I2YQG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Secreted http://togogenome.org/gene/9595:DUSP26 ^@ http://purl.uniprot.org/uniprot/G3REJ5 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/9595:VPS11 ^@ http://purl.uniprot.org/uniprot/G3S6N5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS11 family.|||Cytoplasmic vesicle|||Early endosome|||Late endosome membrane|||Lysosome membrane|||Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.|||autophagosome|||clathrin-coated vesicle http://togogenome.org/gene/9595:PPT1 ^@ http://purl.uniprot.org/uniprot/G3SFD0 ^@ Similarity ^@ Belongs to the palmitoyl-protein thioesterase family. http://togogenome.org/gene/9595:SSH3 ^@ http://purl.uniprot.org/uniprot/G3R6S4 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. http://togogenome.org/gene/9595:VPS35L ^@ http://purl.uniprot.org/uniprot/G3QSB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS35L family.|||Endosome http://togogenome.org/gene/9595:NR5A1 ^@ http://purl.uniprot.org/uniprot/G3R0U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR5 subfamily.|||Nucleus http://togogenome.org/gene/9595:KIF9 ^@ http://purl.uniprot.org/uniprot/G3QM86 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9595:PGK2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z4D3 ^@ Similarity|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Monomer. http://togogenome.org/gene/9595:RTN1 ^@ http://purl.uniprot.org/uniprot/A0A2I2YQS8|||http://purl.uniprot.org/uniprot/A0A2I2ZXC9|||http://purl.uniprot.org/uniprot/G3QST3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9595:IFIH1 ^@ http://purl.uniprot.org/uniprot/G3RIJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/9595:TMEM97 ^@ http://purl.uniprot.org/uniprot/A0A2I2ZIR7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TMEM97/sigma-2 receptor family.|||Endoplasmic reticulum membrane|||Interacts with NPC1.|||Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins.|||Membrane|||Nucleus membrane|||Rough endoplasmic reticulum membrane http://togogenome.org/gene/9595:ILKAP ^@ http://purl.uniprot.org/uniprot/G3QCZ5 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9595:RPS6KA5 ^@ http://purl.uniprot.org/uniprot/G3QNQ7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9595:CKAP5 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z6B4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TOG/XMAP215 family.|||kinetochore http://togogenome.org/gene/9595:TRUB2 ^@ http://purl.uniprot.org/uniprot/G3RFP9 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/9595:GALT ^@ http://purl.uniprot.org/uniprot/G3QKA8 ^@ Cofactor|||Similarity ^@ Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.|||Binds 1 Fe cation per subunit. http://togogenome.org/gene/9595:TAT ^@ http://purl.uniprot.org/uniprot/G3QPU7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. http://togogenome.org/gene/9595:LOC101134211 ^@ http://purl.uniprot.org/uniprot/G3RNP5 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9595:ABT1 ^@ http://purl.uniprot.org/uniprot/G3RRH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESF2/ABP1 family.|||nucleolus http://togogenome.org/gene/9595:PLRG1 ^@ http://purl.uniprot.org/uniprot/G3RZI1 ^@ Similarity ^@ Belongs to the WD repeat PRL1/PRL2 family. http://togogenome.org/gene/9595:ZKSCAN3 ^@ http://purl.uniprot.org/uniprot/G3R228 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:PGGT1B ^@ http://purl.uniprot.org/uniprot/G3QFM5 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit beta family. http://togogenome.org/gene/9595:EDNRB ^@ http://purl.uniprot.org/uniprot/G3RES6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9595:CTSK ^@ http://purl.uniprot.org/uniprot/G3RH85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9595:RNF10 ^@ http://purl.uniprot.org/uniprot/G3S990 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNF10 family.|||Cytoplasm http://togogenome.org/gene/9595:TFDP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2Z1L1|||http://purl.uniprot.org/uniprot/A0A2I2Z4W9|||http://purl.uniprot.org/uniprot/G3QXY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9595:ID1 ^@ http://purl.uniprot.org/uniprot/G3RJ48 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9595:NAB2 ^@ http://purl.uniprot.org/uniprot/G3QGE9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAB family.|||Homomultimers may associate with EGR1 bound to DNA.|||Nucleus http://togogenome.org/gene/9595:ATP1B3 ^@ http://purl.uniprot.org/uniprot/G3RSA6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9595:LOC101137282 ^@ http://purl.uniprot.org/uniprot/G3RGX1 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/9595:ISCU ^@ http://purl.uniprot.org/uniprot/G3R7F6 ^@ Function|||Similarity ^@ Belongs to the NifU family.|||Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5. Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form. May modulate NFS1 desulfurase activity in a zinc-dependent manner. Modulates the interaction between FXN and the cysteine desulfurase complex. http://togogenome.org/gene/9595:DGKA ^@ http://purl.uniprot.org/uniprot/G3RDT9 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic diacylglycerol kinase family.|||Monomer. http://togogenome.org/gene/9595:CASC3 ^@ http://purl.uniprot.org/uniprot/G3QQU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CASC3 family.|||Nucleus speckle|||dendrite|||perinuclear region