http://togogenome.org/gene/9597:MINDY4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGQ9 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM188 subfamily.|||Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. http://togogenome.org/gene/9597:MPHOSPH10 ^@ http://purl.uniprot.org/uniprot/A0A2R9ARM6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MPP10 family.|||Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.|||nucleolus http://togogenome.org/gene/9597:PPIL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ATX8 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9597:SEPSECS ^@ http://purl.uniprot.org/uniprot/A0A2R9BML0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SepSecS family.|||Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.|||Cytoplasm|||Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer. http://togogenome.org/gene/9597:MPV17L2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/9597:IRAK1BP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B404 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRAK1BP1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:SHBG ^@ http://purl.uniprot.org/uniprot/A0A2R9C134 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:P2RX3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BII3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9597:CDK5RAP3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A907 ^@ Similarity ^@ Belongs to the CDK5RAP3 family. http://togogenome.org/gene/9597:SPI1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BGS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9597:FER1L5 ^@ http://purl.uniprot.org/uniprot/A0A2R9A500 ^@ Similarity ^@ Belongs to the ferlin family. http://togogenome.org/gene/9597:ARHGEF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C015 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:LPAR5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEH5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9597:IDO1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A3G1 ^@ Similarity ^@ Belongs to the indoleamine 2,3-dioxygenase family. http://togogenome.org/gene/9597:AMER3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AY54 ^@ Similarity ^@ Belongs to the Amer family. http://togogenome.org/gene/9597:SYNCRIP ^@ http://purl.uniprot.org/uniprot/A0A2R9AVY9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:LOC100968432 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9R6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCR10/QCR9 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9597:CTBP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AUN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Nucleus http://togogenome.org/gene/9597:STX16 ^@ http://purl.uniprot.org/uniprot/A0A2R9BGQ5 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9597:NCOA7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BX20 ^@ Similarity ^@ Belongs to the OXR1 family. http://togogenome.org/gene/9597:METTL14 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9D6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MT-A70-like family.|||Heterodimer; heterodimerizes with METTL3 to form an antiparallel heterodimer that constitutes an active methyltransferase.|||Nucleus|||The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation. In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization. M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis. M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells. http://togogenome.org/gene/9597:FAM174A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM174 family.|||Membrane http://togogenome.org/gene/9597:COPS8 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN8 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:SPRTN ^@ http://purl.uniprot.org/uniprot/A0A2R9BCR3|||http://purl.uniprot.org/uniprot/A0A2R9BGJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Spartan family.|||Chromosome|||Nucleus http://togogenome.org/gene/9597:LUC7L3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPS0 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/9597:PRDM14 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZS07 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:CA11 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1F0 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Does not have a catalytic activity. http://togogenome.org/gene/9597:ERCC5 ^@ http://purl.uniprot.org/uniprot/A0A2R9C1V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.|||Nucleus http://togogenome.org/gene/9597:VAMP5 ^@ http://purl.uniprot.org/uniprot/A0A2R9AEV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9597:EID2B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJ03 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:PGLYRP3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CMU3 ^@ Similarity ^@ Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. http://togogenome.org/gene/9597:HAUS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AWZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HAUS1 family.|||spindle http://togogenome.org/gene/9597:DDX18 ^@ http://purl.uniprot.org/uniprot/A0A2R9AT87 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9597:LDLRAD4 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z883 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMEPA1 family.|||Early endosome membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/9597:UBE4B ^@ http://purl.uniprot.org/uniprot/A0A2R9BSS6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin conjugation factor E4 family.|||Cytoplasm|||The U-box domain is required for the ubiquitin protein ligase activity.|||Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. http://togogenome.org/gene/9597:KLHL21 ^@ http://purl.uniprot.org/uniprot/A0A2R9AC80 ^@ Subcellular Location Annotation ^@ spindle http://togogenome.org/gene/9597:CYP4F3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BI89|||http://purl.uniprot.org/uniprot/A0A2R9BS15 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9597:MAB21L1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQ93 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9597:CKAP2L ^@ http://purl.uniprot.org/uniprot/A0A2R9A109 ^@ Similarity ^@ Belongs to the CKAP2 family. http://togogenome.org/gene/9597:CTNS ^@ http://purl.uniprot.org/uniprot/A0A2R9BNZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cystinosin family.|||Membrane http://togogenome.org/gene/9597:BRF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9APN8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:TPK1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CLA2 ^@ Similarity ^@ Belongs to the thiamine pyrophosphokinase family. http://togogenome.org/gene/9597:CENPL ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-L/IML3 family.|||Nucleus http://togogenome.org/gene/9597:SEC11A ^@ http://purl.uniprot.org/uniprot/A0A2R9C232|||http://purl.uniprot.org/uniprot/A0A2R9C2J8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Component of the signal peptidase complex.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:RAB29 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEE0|||http://purl.uniprot.org/uniprot/A0A2R8ZEE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/9597:AARSD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AN71 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily. http://togogenome.org/gene/9597:LOC100982351 ^@ http://purl.uniprot.org/uniprot/A0A2R9BWJ1 ^@ Subcellular Location Annotation ^@ mitochondrion nucleoid http://togogenome.org/gene/9597:MKS1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTG8 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/9597:LOC100967935 ^@ http://purl.uniprot.org/uniprot/A0A2R9ALS3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:FGF9 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBT9 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9597:CALHM5 ^@ http://purl.uniprot.org/uniprot/A0A2R9BVY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9597:DDX50 ^@ http://purl.uniprot.org/uniprot/A0A2R9CC31 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily. http://togogenome.org/gene/9597:LOC100979972 ^@ http://purl.uniprot.org/uniprot/P61639 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIIc family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Interacts with RAB5IF (By similarity).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:BTG4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CQ48 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9597:LOC100975612 ^@ http://purl.uniprot.org/uniprot/A0A2R9C6F8 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family. eIF4A subfamily.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9597:SENP8 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z824 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/9597:CAMK2N2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZH27 ^@ Similarity ^@ Belongs to the CAMK2N family. http://togogenome.org/gene/9597:BMX ^@ http://purl.uniprot.org/uniprot/A0A2R9BZZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cytoplasm http://togogenome.org/gene/9597:GJA3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQN8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9597:ZACN ^@ http://purl.uniprot.org/uniprot/A0A2R9BAS2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:XG ^@ http://purl.uniprot.org/uniprot/A0A2R9AHM3|||http://purl.uniprot.org/uniprot/A0A2R9APR0 ^@ Similarity ^@ Belongs to the CD99 family. http://togogenome.org/gene/9597:MFN2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZXY7 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9597:SEPTIN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B3R7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cleavage furrow|||Filament-forming cytoskeletal GTPase.|||Midbody|||Septins polymerize into heterooligomeric protein complexes that form filaments.|||cilium membrane|||flagellum|||spindle http://togogenome.org/gene/9597:TIMM8A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZRL5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9597:CDNF ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARMET family.|||Secreted http://togogenome.org/gene/9597:CFL2 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9R1 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. http://togogenome.org/gene/9597:HYAL3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BA36|||http://purl.uniprot.org/uniprot/A0A2R9BCC8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 56 family.|||Cell membrane|||Early endosome|||Endoplasmic reticulum|||Endosome|||Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage.|||Membrane|||acrosome http://togogenome.org/gene/9597:KIF20A ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7U8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9597:PKIG ^@ http://purl.uniprot.org/uniprot/A0A2R9CGG5 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/9597:SLC41A3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BKS9|||http://purl.uniprot.org/uniprot/A0A2R9BTU5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/9597:SGTA ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHE2 ^@ Similarity ^@ Belongs to the SGT family. http://togogenome.org/gene/9597:SATB1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/9597:EDA2R ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCJ5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:LOC100979261 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVB5 ^@ Subcellular Location Annotation|||Subunit ^@ Membrane|||The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta. http://togogenome.org/gene/9597:LOC103786072 ^@ http://purl.uniprot.org/uniprot/A0A2R9A3G6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. http://togogenome.org/gene/9597:LAMB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A2B3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/9597:ENPP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AIM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.|||Secreted http://togogenome.org/gene/9597:LGR5 ^@ http://purl.uniprot.org/uniprot/A0A2R9AWL1|||http://purl.uniprot.org/uniprot/A0A2R9B2G8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:IFNAR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEG7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II cytokine receptor family.|||Cell membrane|||Endosome|||Heterodimer with IFNAR2.|||Late endosome|||Lysosome|||Membrane|||Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway. http://togogenome.org/gene/9597:LOC100969204 ^@ http://purl.uniprot.org/uniprot/A0A2R9CIX3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS21 family.|||Component of the 40S small ribosomal subunit.|||Endoplasmic reticulum|||Rough endoplasmic reticulum|||cytosol http://togogenome.org/gene/9597:VMA21 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z5P5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the V0 complex of the vacuolar ATPase (V-ATPase).|||Belongs to the VMA21 family.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum. http://togogenome.org/gene/9597:SDR9C7 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9Y3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9597:UBE2A ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7N0 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9597:SNX3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AMC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome|||Endosome|||phagosome http://togogenome.org/gene/9597:TSPAN2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9597:GJB1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZC06 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins. Interacts with CNST.|||Belongs to the connexin family. Beta-type (group I) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9597:HSP90B1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BR22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 90 family.|||Melanosome http://togogenome.org/gene/9597:PDK4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9597:TRNAU1AP ^@ http://purl.uniprot.org/uniprot/A0A2R9AW67 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TRSPAP family.|||Cytoplasm|||Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis.|||Nucleus http://togogenome.org/gene/9597:LOC100985167 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQL1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:ACTA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZU8 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9597:CDC42SE1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BGD0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CDC42SE/SPEC family.|||Cell membrane|||Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.|||Membrane|||Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.|||cytoskeleton http://togogenome.org/gene/9597:POU2F3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BHB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-2 subfamily.|||Nucleus http://togogenome.org/gene/9597:EBAG9 ^@ http://purl.uniprot.org/uniprot/A0A2R9B0N6 ^@ Function|||Subcellular Location Annotation ^@ Golgi apparatus membrane|||May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. http://togogenome.org/gene/9597:GMDS ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSP9 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. http://togogenome.org/gene/9597:KCNA1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFZ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:ORC3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BMI2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC3 family.|||Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.|||Nucleus http://togogenome.org/gene/9597:ITPKB ^@ http://purl.uniprot.org/uniprot/A0A2R9AXD5 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9597:ANAPC13 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACC0 ^@ Function|||Similarity ^@ Belongs to the APC13 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. http://togogenome.org/gene/9597:CHSY1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C2N3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9597:ADPRS ^@ http://purl.uniprot.org/uniprot/A0A2R9C936 ^@ Similarity ^@ Belongs to the ADP-ribosylglycohydrolase family. http://togogenome.org/gene/9597:NUP50 ^@ http://purl.uniprot.org/uniprot/A0A2R9ATL1 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/9597:SLC27A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CKC4 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9597:NIPAL3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B3W9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9597:TENT5A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZJ1 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/9597:TIMM22 ^@ http://purl.uniprot.org/uniprot/A0A2R9B4J1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM22 complex.|||Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9597:TLCD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B902 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:HAO1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZF43 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/9597:RAB38 ^@ http://purl.uniprot.org/uniprot/A0A2R9BF11 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/9597:TM4SF4 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9597:LOC100981957 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9597:LOC100984043 ^@ http://purl.uniprot.org/uniprot/A0A2R9A954 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:SNRPG ^@ http://purl.uniprot.org/uniprot/A0A2R9AAU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus|||Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.|||cytosol http://togogenome.org/gene/9597:ZNF444 ^@ http://purl.uniprot.org/uniprot/A0A2R9BZ75 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:MED11 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZI02 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 11 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9597:TMEM135 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZH39|||http://purl.uniprot.org/uniprot/A0A2R8ZJR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM135 family.|||Membrane http://togogenome.org/gene/9597:ACOX3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/9597:SSTR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDJ5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9597:COG7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJ84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG7 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:PSME2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZA22 ^@ Similarity ^@ Belongs to the PA28 family. http://togogenome.org/gene/9597:BCAN ^@ http://purl.uniprot.org/uniprot/A0A2R9BXM3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aggrecan/versican proteoglycan family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9597:GRWD1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUH4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:PTDSS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C088 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphatidyl serine synthase family.|||Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:ARMC9 ^@ http://purl.uniprot.org/uniprot/A0A2R9CMS4 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with TOGARAM1, CCDC66, CEP104, CSPP1 and CEP290.|||centriole|||cilium|||cilium basal body http://togogenome.org/gene/9597:MCM3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A466 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/9597:MAP1LC3B2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZA12 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9597:IL15 ^@ http://purl.uniprot.org/uniprot/A0A2R9CIQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Secreted http://togogenome.org/gene/9597:ZNF12 ^@ http://purl.uniprot.org/uniprot/A0A2R9A3E5 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:EPAS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BIT2 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/9597:CPS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BH47 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:NSMCE1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CHD1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NSE1 family.|||Component of the Smc5-Smc6 complex.|||Nucleus|||RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.|||telomere http://togogenome.org/gene/9597:SCGB2A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C1P9 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9597:ARG2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CNG5 ^@ Cofactor|||Similarity ^@ Belongs to the arginase family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9597:TFAP2C ^@ http://purl.uniprot.org/uniprot/A0A2R9AQD2 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/9597:LMBR1L ^@ http://purl.uniprot.org/uniprot/A0A2R9CHP9 ^@ Similarity ^@ Belongs to the LIMR family. http://togogenome.org/gene/9597:SSR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AMU5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-alpha family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.|||Membrane|||Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. http://togogenome.org/gene/9597:NELL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BHN3|||http://purl.uniprot.org/uniprot/A0A2R9BHP0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:CDC25A ^@ http://purl.uniprot.org/uniprot/A0A2R9B0S6 ^@ Function|||Similarity ^@ Belongs to the MPI phosphatase family.|||Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. http://togogenome.org/gene/9597:PCMTD2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMW6 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/9597:PPM1L ^@ http://purl.uniprot.org/uniprot/A0A2R9CE87 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9597:TLR10 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHQ6|||http://purl.uniprot.org/uniprot/B3Y670 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9597:FAM149A ^@ http://purl.uniprot.org/uniprot/A0A2R9B278 ^@ Similarity ^@ Belongs to the FAM149 family. http://togogenome.org/gene/9597:PWP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BMW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat PWP2 family.|||nucleolus http://togogenome.org/gene/9597:LYZL6 ^@ http://purl.uniprot.org/uniprot/A0A2R9ALD5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9597:EPHB1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZM22 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||dendrite http://togogenome.org/gene/9597:RAD21 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad21 family.|||Nucleus http://togogenome.org/gene/9597:EMG1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXE4 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family. http://togogenome.org/gene/9597:TPST1 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7U4|||http://purl.uniprot.org/uniprot/A0A2R8Z821 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein sulfotransferase family.|||Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.|||Golgi apparatus membrane http://togogenome.org/gene/9597:RANBP17 ^@ http://purl.uniprot.org/uniprot/A0A2R9CHP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:ING2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CAK7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9597:LOC100971602 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXC7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9597:CRBN ^@ http://purl.uniprot.org/uniprot/A0A2R9CKP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRBN family.|||Nucleus http://togogenome.org/gene/9597:GHRHR ^@ http://purl.uniprot.org/uniprot/A0A2R9AAT3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:SEMA4F ^@ http://purl.uniprot.org/uniprot/A0A2R9CL15|||http://purl.uniprot.org/uniprot/A0A2R9CL37|||http://purl.uniprot.org/uniprot/A0A2R9CNB4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:ATP6V1E1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJF0 ^@ Similarity ^@ Belongs to the V-ATPase E subunit family. http://togogenome.org/gene/9597:HYAL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AAT0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/9597:VDAC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BFY0 ^@ Similarity ^@ Belongs to the eukaryotic mitochondrial porin family. http://togogenome.org/gene/9597:SESN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BC26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/9597:ZNF441 ^@ http://purl.uniprot.org/uniprot/A0A2R9BHM1 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:RNF20 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5Y6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BRE1 family.|||Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.|||Nucleus http://togogenome.org/gene/9597:NHEJ1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CEQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XRCC4-XLF family. XLF subfamily.|||Nucleus http://togogenome.org/gene/9597:STAMBPL1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNB1 ^@ Similarity ^@ Belongs to the peptidase M67C family. http://togogenome.org/gene/9597:SDHAF3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BID7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I LYR family. SDHAF3 subfamily.|||Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.|||Mitochondrion matrix|||Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1. http://togogenome.org/gene/9597:GNAT3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVH6 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9597:TSN ^@ http://purl.uniprot.org/uniprot/A0A2R9APV2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the translin family.|||DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.|||Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.|||Nucleus|||Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring. http://togogenome.org/gene/9597:LOC100972374 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLM8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:EIF4E2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B0X3|||http://purl.uniprot.org/uniprot/A0A2R9B2B9|||http://purl.uniprot.org/uniprot/A0A2R9B4S9|||http://purl.uniprot.org/uniprot/A0A2R9B799 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/9597:MTHFR ^@ http://purl.uniprot.org/uniprot/A0A2R9BUM3 ^@ Similarity ^@ Belongs to the methylenetetrahydrofolate reductase family. http://togogenome.org/gene/9597:NEMF ^@ http://purl.uniprot.org/uniprot/A0A2R9ASD9 ^@ Similarity ^@ Belongs to the NEMF family. http://togogenome.org/gene/9597:AURKC ^@ http://purl.uniprot.org/uniprot/A0A2R9C9K6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. http://togogenome.org/gene/9597:HEXB ^@ http://purl.uniprot.org/uniprot/A0A2R9CF26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 20 family.|||Lysosome http://togogenome.org/gene/9597:FRK ^@ http://purl.uniprot.org/uniprot/A0A2R9BRU0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9597:ADH4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDG7|||http://purl.uniprot.org/uniprot/A0A2R9CNV9 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/9597:MAL ^@ http://purl.uniprot.org/uniprot/A0A2R9BS55 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:SERPINB2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BU70 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9597:ZNF205 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABJ3 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:KYNU ^@ http://purl.uniprot.org/uniprot/A0A2R8ZE77 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kynureninase family.|||Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:RNF114 ^@ http://purl.uniprot.org/uniprot/A0A2R9CS64 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.|||Nucleus http://togogenome.org/gene/9597:ISX ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKJ5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:TRIM36 ^@ http://purl.uniprot.org/uniprot/A0A2R9BP33 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9597:HSPB8 ^@ http://purl.uniprot.org/uniprot/A0A2R9AWK4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Cytoplasm|||Displays temperature-dependent chaperone activity.|||Nucleus http://togogenome.org/gene/9597:SMPX ^@ http://purl.uniprot.org/uniprot/A0A2R9A9X5 ^@ Function|||Similarity ^@ Belongs to the SMPX family.|||Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair. http://togogenome.org/gene/9597:SDC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B549 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane http://togogenome.org/gene/9597:RBM48 ^@ http://purl.uniprot.org/uniprot/A0A2R9BU12 ^@ Function|||Similarity|||Subunit ^@ As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.|||Belongs to the RBM48 family.|||Component of the minor spliceosome. Within this complex, interacts with ARMC7 and PRPF8/PRP8. http://togogenome.org/gene/9597:LIMS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BH15 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.|||Cell membrane|||Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.|||focal adhesion http://togogenome.org/gene/9597:OAS1 ^@ http://purl.uniprot.org/uniprot/B6RC68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-5A synthase family.|||Cytoplasm http://togogenome.org/gene/9597:FAM3B ^@ http://purl.uniprot.org/uniprot/A0A2R9AGR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/9597:ENTPD6 ^@ http://purl.uniprot.org/uniprot/A0A2R9ALI8 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9597:NINJ2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ninjurin family.|||Membrane http://togogenome.org/gene/9597:DGAT2L6 ^@ http://purl.uniprot.org/uniprot/A0A2R9AYH5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:SKIL ^@ http://purl.uniprot.org/uniprot/A0A2R9A8L9|||http://purl.uniprot.org/uniprot/A0A2R9A8M4 ^@ Similarity ^@ Belongs to the SKI family. http://togogenome.org/gene/9597:NOC3L ^@ http://purl.uniprot.org/uniprot/A0A2R9CK72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CBF/MAK21 family.|||nucleolus http://togogenome.org/gene/9597:NDUFA12 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLF4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA12 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:MOCS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CEX6 ^@ Similarity ^@ In the C-terminal section; belongs to the MoaC family.|||In the N-terminal section; belongs to the radical SAM superfamily. MoaA family. http://togogenome.org/gene/9597:CWF19L1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ASJ2 ^@ Similarity ^@ Belongs to the CWF19 family. http://togogenome.org/gene/9597:TNS4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTEN phosphatase protein family.|||focal adhesion http://togogenome.org/gene/9597:TMCC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ADG7 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/9597:CTNNA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BZX4|||http://purl.uniprot.org/uniprot/A0A2R9C0I6|||http://purl.uniprot.org/uniprot/A0A2R9CA35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vinculin/alpha-catenin family.|||Cell membrane|||Membrane|||adherens junction http://togogenome.org/gene/9597:SLC39A9 ^@ http://purl.uniprot.org/uniprot/A0A2R9AF04|||http://purl.uniprot.org/uniprot/A0A2R9AJU5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Cell membrane|||Membrane|||Mitochondrion|||Nucleus|||Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process.|||perinuclear region|||trans-Golgi network membrane http://togogenome.org/gene/9597:TRMT61A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZL0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.|||Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.|||Nucleus http://togogenome.org/gene/9597:PSMG2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACY4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PSMG2 family.|||Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.|||Forms a heterodimer with PSMG1. http://togogenome.org/gene/9597:SKA3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BI31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SKA3 family.|||kinetochore|||spindle http://togogenome.org/gene/9597:SAP130 ^@ http://purl.uniprot.org/uniprot/A0A2R9BNT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAP130 family.|||Nucleus http://togogenome.org/gene/9597:ZNF449 ^@ http://purl.uniprot.org/uniprot/A1YFW6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9597:ETV3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A6A5|||http://purl.uniprot.org/uniprot/A1YG91 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus|||Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity (By similarity). http://togogenome.org/gene/9597:APOC3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZG19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the apolipoprotein C3 family.|||Secreted http://togogenome.org/gene/9597:ACSM4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AFR0 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9597:ROCK1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BZ36 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by RHOA binding. Inhibited by Y-27632.|||Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.|||Cytoplasm|||Homodimer.|||Membrane|||Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. http://togogenome.org/gene/9597:IVD ^@ http://purl.uniprot.org/uniprot/A0A2R9A7H7 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9597:LOC100974724 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBM6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:TNFRSF10A ^@ http://purl.uniprot.org/uniprot/A0A2R9C3Q3 ^@ Caution|||Function ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. http://togogenome.org/gene/9597:TLR1 ^@ http://purl.uniprot.org/uniprot/B3Y607 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane|||Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. http://togogenome.org/gene/9597:LOC100971127 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYI1 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the lipoxygenase family.|||Binds 1 Fe cation per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:PLCB3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CAD8 ^@ Cofactor|||Function ^@ Binds 1 Ca(2+) ion per subunit.|||The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. http://togogenome.org/gene/9597:RBM22 ^@ http://purl.uniprot.org/uniprot/A0A2R9B305 ^@ Similarity ^@ Belongs to the SLT11 family. http://togogenome.org/gene/9597:PARK7 ^@ http://purl.uniprot.org/uniprot/A0A2R9AGT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C56 family.|||Membrane raft http://togogenome.org/gene/9597:PRKAA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B7U6|||http://purl.uniprot.org/uniprot/A0A2R9BBM3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. http://togogenome.org/gene/9597:LOC106635432 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9M6 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9597:HIGD1B ^@ http://purl.uniprot.org/uniprot/A0A2R9BGG4 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/9597:LOC103783978 ^@ http://purl.uniprot.org/uniprot/A0A2R9CPL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 6A family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9597:LOC100972994 ^@ http://purl.uniprot.org/uniprot/A0A2R9CFN7 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Lysosome membrane http://togogenome.org/gene/9597:GFAP ^@ http://purl.uniprot.org/uniprot/A0A2R9CBF8 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9597:ADCY7 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZW57 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/9597:CLPP ^@ http://purl.uniprot.org/uniprot/A0A2R9CDX0 ^@ Similarity ^@ Belongs to the peptidase S14 family. http://togogenome.org/gene/9597:COPA ^@ http://purl.uniprot.org/uniprot/A0A2R9A2F0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. http://togogenome.org/gene/9597:NDP ^@ http://purl.uniprot.org/uniprot/A0A2R9A195 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9597:CDC42EP3 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z776 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/9597:APEH ^@ http://purl.uniprot.org/uniprot/A0A2R9C4F1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S9C family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/9597:HINT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUQ1 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/9597:MAPK7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BV16 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9597:IK ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RED family.|||Nucleus http://togogenome.org/gene/9597:IRF6 ^@ http://purl.uniprot.org/uniprot/A0A2R9AW22 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:OOEP ^@ http://purl.uniprot.org/uniprot/A0A2R9BPN2 ^@ Similarity ^@ Belongs to the KHDC1 family. http://togogenome.org/gene/9597:CTSA ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSD6|||http://purl.uniprot.org/uniprot/A0A2R8ZV77 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/9597:IDH1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BW49 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Homodimer. http://togogenome.org/gene/9597:CALCRL ^@ http://purl.uniprot.org/uniprot/A0A2R9BXQ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.|||Membrane|||Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. http://togogenome.org/gene/9597:XPR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SYG1 (TC 2.A.94) family.|||Membrane http://togogenome.org/gene/9597:FH ^@ http://purl.uniprot.org/uniprot/A0A2R9A8K1 ^@ Function|||Similarity ^@ Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.|||Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. http://togogenome.org/gene/9597:TMEM94 ^@ http://purl.uniprot.org/uniprot/A0A2R9CNB1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:NFYB ^@ http://purl.uniprot.org/uniprot/A0A2R9C725 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NFYB/HAP3 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.|||Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP. http://togogenome.org/gene/9597:ASB10 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4I6|||http://purl.uniprot.org/uniprot/A0A2R9C4X4|||http://purl.uniprot.org/uniprot/A0A2R9C7H8 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9597:ACSS3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C396 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9597:ACER2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BD30 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:BRS3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AGX3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with C6orf89.|||Membrane http://togogenome.org/gene/9597:CHMP4A ^@ http://purl.uniprot.org/uniprot/A0A2R9CC56 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9597:SGK3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BP29 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/9597:PTPN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BT42 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. http://togogenome.org/gene/9597:RAP2A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLW6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Palmitoylated.|||Recycling endosome membrane|||Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. http://togogenome.org/gene/9597:ELMO2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A3F4 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. http://togogenome.org/gene/9597:ATP5MC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C6Y9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/9597:RARG ^@ http://purl.uniprot.org/uniprot/A0A2R9A872 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9597:FAM210A ^@ http://purl.uniprot.org/uniprot/A0A2R9BGK8 ^@ Similarity ^@ Belongs to the FAM210 family. http://togogenome.org/gene/9597:RCAN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A2S3|||http://purl.uniprot.org/uniprot/A0A2R9A643 ^@ Function|||Similarity ^@ Belongs to the RCAN family.|||Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. http://togogenome.org/gene/9597:CNNM3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CGX7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ACDP family.|||Cell membrane|||Metal transporter. http://togogenome.org/gene/9597:DNAJC24 ^@ http://purl.uniprot.org/uniprot/A0A2R9ANH5 ^@ Similarity ^@ Belongs to the DPH4 family. http://togogenome.org/gene/9597:JAGN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the jagunal family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:RFT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B8R5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RFT1 family.|||May be involved in N-linked oligosaccharide assembly.|||Membrane http://togogenome.org/gene/9597:RGS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BEH1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||nucleolus http://togogenome.org/gene/9597:LCORL ^@ http://purl.uniprot.org/uniprot/A0A2R9BTZ1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:ALG11 ^@ http://purl.uniprot.org/uniprot/A0A2R9B5J5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.|||Endoplasmic reticulum membrane|||Required for N-linked oligosaccharide assembly. http://togogenome.org/gene/9597:PRPF4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CB33 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/9597:PADI4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AGC3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein arginine deiminase family.|||Catalyzes the deimination of arginine residues of proteins.|||Cytoplasm http://togogenome.org/gene/9597:CYFIP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYFIP family.|||synaptosome http://togogenome.org/gene/9597:DSCC1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGV0 ^@ Similarity ^@ Belongs to the DCC1 family. http://togogenome.org/gene/9597:S100A6 ^@ http://purl.uniprot.org/uniprot/A0A2R9A6E4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the S-100 family.|||May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.|||Nucleus envelope http://togogenome.org/gene/9597:IL10 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZE59 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/9597:ANXA3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXV0 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9597:ATP1B4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BY14 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9597:CNTFR ^@ http://purl.uniprot.org/uniprot/A0A2R9C7G4 ^@ Similarity ^@ Belongs to the type I cytokine receptor family. Type 3 subfamily. http://togogenome.org/gene/9597:GABRA2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZ28|||http://purl.uniprot.org/uniprot/A0A2R9A081 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||dendrite http://togogenome.org/gene/9597:HSD17B11 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZH80 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9597:CCL5 ^@ http://purl.uniprot.org/uniprot/A0A2R9CSX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9597:OGT ^@ http://purl.uniprot.org/uniprot/A0A2R9AEH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.|||Cell projection|||Mitochondrion membrane http://togogenome.org/gene/9597:VPS45 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUS7 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9597:KBTBD8 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7L2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KBTBD8 family.|||Golgi apparatus|||spindle http://togogenome.org/gene/9597:GPR3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:ATG4A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNT9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/9597:RFTN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the raftlin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:IRF9 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDH2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:SEPHS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTM4 ^@ Function ^@ Synthesizes selenophosphate from selenide and ATP. http://togogenome.org/gene/9597:LOC100973061 ^@ http://purl.uniprot.org/uniprot/A0A2R9CIL5 ^@ Similarity ^@ Belongs to the cytochrome c oxidase VIIa family. http://togogenome.org/gene/9597:SNX17 ^@ http://purl.uniprot.org/uniprot/A0A2R9CN12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane|||Early endosome|||Endosome|||Membrane http://togogenome.org/gene/9597:ZNF382 ^@ http://purl.uniprot.org/uniprot/A0A2R9ASL8 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:TMED1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9597:MAPK4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAT0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9597:HSCB ^@ http://purl.uniprot.org/uniprot/A0A2R9ALN2 ^@ Similarity ^@ Belongs to the HscB family. http://togogenome.org/gene/9597:LOC100983379 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6H2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:AGPAT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BV35 ^@ Domain|||Function|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/9597:TMEM144 ^@ http://purl.uniprot.org/uniprot/A0A2R9AD68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM144 family.|||Membrane http://togogenome.org/gene/9597:STK10 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Cell membrane http://togogenome.org/gene/9597:UPK1B ^@ http://purl.uniprot.org/uniprot/A0A2R9BNL6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:HTN1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histatin/statherin family.|||Secreted http://togogenome.org/gene/9597:GADD45B ^@ http://purl.uniprot.org/uniprot/A0A2R9CMK8 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/9597:NPY1R ^@ http://purl.uniprot.org/uniprot/A0A2R9CMK6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9597:Papa-A ^@ http://purl.uniprot.org/uniprot/Q30900 ^@ Similarity|||Subunit ^@ Belongs to the MHC class I family.|||Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). http://togogenome.org/gene/9597:BSX ^@ http://purl.uniprot.org/uniprot/A0A2R9C627 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:AMD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CP40 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic AdoMetDC family.|||Binds 1 pyruvoyl group covalently per subunit.|||Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.|||Heterotetramer of two alpha and two beta chains. http://togogenome.org/gene/9597:NR0B2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR0 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:ACTL10 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZWT6 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9597:LOC100974904 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDN1 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:TFB1M ^@ http://purl.uniprot.org/uniprot/A0A2R9ADI6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.|||Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.|||S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. http://togogenome.org/gene/9597:SDC4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSI0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane http://togogenome.org/gene/9597:ACTL6A ^@ http://purl.uniprot.org/uniprot/A0A2R9AKF6 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9597:EEF1AKMT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C8B4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.|||Cytoplasm|||Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.|||Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure. http://togogenome.org/gene/9597:PRPSAP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ANY8 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/9597:UBA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AE16 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ubiquitin-activating E1 family.|||Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.|||Nucleus|||The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. http://togogenome.org/gene/9597:LOC100987164 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJ63 ^@ Similarity ^@ Belongs to the SKP1 family. http://togogenome.org/gene/9597:NTN4 ^@ http://purl.uniprot.org/uniprot/A0A2R9A3J5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:TBPL1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHH2 ^@ Similarity|||Subunit ^@ Belongs to the TBP family.|||Binds TFIIA and TFIIB. http://togogenome.org/gene/9597:ITGAV ^@ http://purl.uniprot.org/uniprot/A0A2R9B7W7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9597:MGME1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A2R5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGME1 family.|||Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair.|||Mitochondrion http://togogenome.org/gene/9597:LOC100987460 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCN6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:SASS6 ^@ http://purl.uniprot.org/uniprot/A0A2R9ALG5 ^@ Subcellular Location Annotation ^@ centrosome http://togogenome.org/gene/9597:ZNF667 ^@ http://purl.uniprot.org/uniprot/A0A2R9C868 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:HOXA7 ^@ http://purl.uniprot.org/uniprot/A0A2R9AYE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9597:FOXJ2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C3N6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:ERLEC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C749|||http://purl.uniprot.org/uniprot/A0A2R9C9X8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OS-9 family.|||Endoplasmic reticulum lumen|||Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation. http://togogenome.org/gene/9597:PARPBP ^@ http://purl.uniprot.org/uniprot/A0A2R9BME9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PARI family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:AK5 ^@ http://purl.uniprot.org/uniprot/A0A2R9AW32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylate kinase family.|||Cytoplasm http://togogenome.org/gene/9597:WNT1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPY6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9597:MRPS18B ^@ http://purl.uniprot.org/uniprot/A0A2R9BVF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.|||Mitochondrion http://togogenome.org/gene/9597:DEFB114 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABV6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9597:OTOP3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AFC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the otopetrin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:CEBPZ ^@ http://purl.uniprot.org/uniprot/A0A2R9CR99 ^@ Similarity ^@ Belongs to the CBF/MAK21 family. http://togogenome.org/gene/9597:GDPD2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGG7 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9597:NLRP14 ^@ http://purl.uniprot.org/uniprot/A0A2R9C0B5 ^@ Similarity ^@ Belongs to the NLRP family. http://togogenome.org/gene/9597:LOC100987260 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9597:HK2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BNP9 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/9597:GPT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BCX8 ^@ Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/9597:SNAPIN ^@ http://purl.uniprot.org/uniprot/A0A2R9BL68 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAPIN family.|||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.|||synaptic vesicle membrane http://togogenome.org/gene/9597:GTF2A2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BP38 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 2 family.|||Nucleus|||TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. http://togogenome.org/gene/9597:ABI1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BPX0|||http://purl.uniprot.org/uniprot/A0A2R9BPY7|||http://purl.uniprot.org/uniprot/A0A2R9BQM8|||http://purl.uniprot.org/uniprot/A0A2R9BTE7|||http://purl.uniprot.org/uniprot/A0A2R9BYZ2|||http://purl.uniprot.org/uniprot/A0A2R9BYZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABI family.|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/9597:SLC28A3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BPV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Membrane http://togogenome.org/gene/9597:AVPR1B ^@ http://purl.uniprot.org/uniprot/A0A2R9BIK4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane|||Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. http://togogenome.org/gene/9597:TM4SF18 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9597:MRPL50 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZV16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL50 family.|||Mitochondrion http://togogenome.org/gene/9597:ALKBH6 ^@ http://purl.uniprot.org/uniprot/A0A2R9BCU9|||http://purl.uniprot.org/uniprot/A0A2R9BGS0 ^@ Similarity ^@ Belongs to the alkB family. http://togogenome.org/gene/9597:ARF4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BFR6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/9597:RNGTT ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMZ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.|||In the C-terminal section; belongs to the eukaryotic GTase family.|||In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.|||Nucleus http://togogenome.org/gene/9597:SERPINB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CF34 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9597:PER1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C274 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9597:ELAC2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase Z family.|||mitochondrion nucleoid http://togogenome.org/gene/9597:LSM6 ^@ http://purl.uniprot.org/uniprot/A0A2R9BKB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/9597:CNIH3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CBU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/9597:ARL6 ^@ http://purl.uniprot.org/uniprot/A0A2R9CMQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||cilium membrane http://togogenome.org/gene/9597:PCOLCE2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AA73 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9597:UBE2G2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AH46 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9597:GPM6A ^@ http://purl.uniprot.org/uniprot/A0A2R9CEY0|||http://purl.uniprot.org/uniprot/A0A2R9CF51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/9597:TUT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BGB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B-like family.|||Nucleus speckle|||nucleolus http://togogenome.org/gene/9597:BMP10 ^@ http://purl.uniprot.org/uniprot/A0A2R9CI72 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9597:PEX16 ^@ http://purl.uniprot.org/uniprot/A0A2R9CBX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-16 family.|||Peroxisome membrane http://togogenome.org/gene/9597:GRHPR ^@ http://purl.uniprot.org/uniprot/A0A2R9BIX8 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/9597:SLC25A53 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9597:LOC100982531 ^@ http://purl.uniprot.org/uniprot/A0A2R9A4U4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:POMT1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUX0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/9597:GDPD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AYR7 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9597:AXL ^@ http://purl.uniprot.org/uniprot/A0A2R9BJ67|||http://purl.uniprot.org/uniprot/A0A2R9BLV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.|||Membrane http://togogenome.org/gene/9597:BZW1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A2I6 ^@ Similarity ^@ Belongs to the BZW family. http://togogenome.org/gene/9597:FGF14 ^@ http://purl.uniprot.org/uniprot/A0A2R9BRI2 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9597:GALK1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVN8 ^@ Similarity ^@ Belongs to the GHMP kinase family. GalK subfamily. http://togogenome.org/gene/9597:CRYAB ^@ http://purl.uniprot.org/uniprot/A0A2R9CGA6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.|||Nucleus http://togogenome.org/gene/9597:IFI27 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFI6/IFI27 family.|||Membrane http://togogenome.org/gene/9597:ACOX2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A996 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/9597:TADA3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NGG1 family.|||Nucleus http://togogenome.org/gene/9597:METTL4 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACH1 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/9597:GGH ^@ http://purl.uniprot.org/uniprot/A0A2R9BLC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C26 family.|||extracellular space http://togogenome.org/gene/9597:FAM98B ^@ http://purl.uniprot.org/uniprot/A0A2R9BM14 ^@ Similarity ^@ Belongs to the FAM98 family. http://togogenome.org/gene/9597:FNTB ^@ http://purl.uniprot.org/uniprot/A0A2R9AQT6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the protein prenyltransferase subunit beta family.|||Binds 1 zinc ion per subunit.|||Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.|||Heterodimer of FNTA and FNTB. http://togogenome.org/gene/9597:LOC100985779 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPM7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9597:S100PBP ^@ http://purl.uniprot.org/uniprot/A0A2R9ABU9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:BCL2A1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJX9 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9597:XRCC4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BZA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XRCC4-XLF family. XRCC4 subfamily.|||Nucleus http://togogenome.org/gene/9597:CCL15 ^@ http://purl.uniprot.org/uniprot/A0A2R9B897 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9597:SZRD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJF1|||http://purl.uniprot.org/uniprot/A0A2R9ARK1 ^@ Similarity ^@ Belongs to the SZRD1 family. http://togogenome.org/gene/9597:TMEM178B ^@ http://purl.uniprot.org/uniprot/A0A2R8Z743 ^@ Similarity ^@ Belongs to the TMEM178 family. http://togogenome.org/gene/9597:CCR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9597:MINDY2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C0C7 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM63 subfamily.|||Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover. http://togogenome.org/gene/9597:VHL ^@ http://purl.uniprot.org/uniprot/A0A2R9B5S8|||http://purl.uniprot.org/uniprot/A0A2R9BCX6 ^@ Similarity ^@ Belongs to the VHL family. http://togogenome.org/gene/9597:WDR55 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDN7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR55 family.|||Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis.|||nucleolus http://togogenome.org/gene/9597:PSMD13 ^@ http://purl.uniprot.org/uniprot/A0A2R9CM00 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S11 family.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. http://togogenome.org/gene/9597:KCNAB3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZH61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shaker potassium channel beta subunit family.|||Cytoplasm http://togogenome.org/gene/9597:CCDC103 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZE44 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CCDC103/PR46b family.|||Cytoplasm|||Dynein-attachment factor required for cilia motility.|||Homodimer.|||flagellum http://togogenome.org/gene/9597:SLC25A13 ^@ http://purl.uniprot.org/uniprot/A0A2R9B4H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9597:CXCL16 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZR36 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:LAMP5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZH08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9597:TAS2R10 ^@ http://purl.uniprot.org/uniprot/Q646D7 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane|||Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.|||Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). http://togogenome.org/gene/9597:CORO2A ^@ http://purl.uniprot.org/uniprot/A0A2R9C3A8 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/9597:SMPD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ANF2 ^@ Similarity ^@ Belongs to the neutral sphingomyelinase family. http://togogenome.org/gene/9597:LOC100967790 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJ20 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:CENPJ ^@ http://purl.uniprot.org/uniprot/A0A2R9AAS2 ^@ Similarity ^@ Belongs to the TCP10 family. http://togogenome.org/gene/9597:CREG1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CREG family.|||Secreted http://togogenome.org/gene/9597:FUNDC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FUN14 family.|||Mitochondrion outer membrane http://togogenome.org/gene/9597:MTFR2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C2G0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission. http://togogenome.org/gene/9597:REEP4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BBT2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:SEMA3E ^@ http://purl.uniprot.org/uniprot/A0A2R9A876 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:BCCIP ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMB1|||http://purl.uniprot.org/uniprot/A0A2R8ZQI1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCP1 family.|||May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).|||Nucleus|||spindle pole http://togogenome.org/gene/9597:CCL22 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9597:ELOVL6 ^@ http://purl.uniprot.org/uniprot/A0A2R9AUT1 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL6 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||N-Glycosylated. http://togogenome.org/gene/9597:EXTL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BBV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:LOC100980365 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDY2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:BCLAF3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7Q7 ^@ Similarity ^@ Belongs to the BCLAF1/THRAP3 family. http://togogenome.org/gene/9597:RBKS ^@ http://purl.uniprot.org/uniprot/A0A2R9AXG3 ^@ Activity Regulation|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Belongs to the carbohydrate kinase pfkB family.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Nucleus|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/9597:TAF11 ^@ http://purl.uniprot.org/uniprot/A0A2R9C8S6|||http://purl.uniprot.org/uniprot/A0A2R9CGM7 ^@ Similarity ^@ Belongs to the TAF11 family. http://togogenome.org/gene/9597:UTP11 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9M7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UTP11 family.|||Component of the ribosomal small subunit (SSU) processome.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/9597:LOC103784619 ^@ http://purl.uniprot.org/uniprot/A0A2R9AL82 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:MTNR1B ^@ http://purl.uniprot.org/uniprot/A0A2R9ADD5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.|||Membrane http://togogenome.org/gene/9597:ZNF112 ^@ http://purl.uniprot.org/uniprot/A0A2R9C319|||http://purl.uniprot.org/uniprot/A0A2R9CA15 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:AKAP12 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZT05|||http://purl.uniprot.org/uniprot/A0A2R8ZYS7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:GEM ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMM8 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/9597:MRPL16 ^@ http://purl.uniprot.org/uniprot/A0A2R9BS01 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/9597:MOGAT3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CLU9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:TEC ^@ http://purl.uniprot.org/uniprot/A0A2R9AFD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cytoplasm http://togogenome.org/gene/9597:LOC100976323 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGF2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:CAPN12 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTR5 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9597:PLSCR2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPV5 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/9597:AMPD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BAW9|||http://purl.uniprot.org/uniprot/A0A2R9BD70 ^@ Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.|||Homotetramer. http://togogenome.org/gene/9597:ROMO1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQZ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGR2 family.|||Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.|||Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:NQO1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ATE6 ^@ Similarity ^@ Belongs to the NAD(P)H dehydrogenase (quinone) family. http://togogenome.org/gene/9597:TLL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C077 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:DPH2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BW78 ^@ Function|||Similarity ^@ Belongs to the DPH1/DPH2 family. DPH2 subfamily.|||Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit. http://togogenome.org/gene/9597:ALKAL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C248 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALKAL family.|||Secreted http://togogenome.org/gene/9597:CSRNP3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B103 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AXUD1 family.|||Nucleus http://togogenome.org/gene/9597:MAP3K12 ^@ http://purl.uniprot.org/uniprot/A0A2R9C1I8 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||May be an activator of the JNK/SAPK pathway. http://togogenome.org/gene/9597:MMP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYR5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||extracellular matrix http://togogenome.org/gene/9597:POSTN ^@ http://purl.uniprot.org/uniprot/A0A2R9ABE0|||http://purl.uniprot.org/uniprot/A0A2R9ABE4|||http://purl.uniprot.org/uniprot/A0A2R9ABW4|||http://purl.uniprot.org/uniprot/A0A2R9ABY3 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9597:EXOSC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B0Y2|||http://purl.uniprot.org/uniprot/A0A2R9B7H9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP4 family.|||Cytoplasm http://togogenome.org/gene/9597:ESYT3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZI25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the extended synaptotagmin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:CFAP91 ^@ http://purl.uniprot.org/uniprot/A0A2R9A165 ^@ Similarity ^@ Belongs to the CFAP91 family. http://togogenome.org/gene/9597:IL17F ^@ http://purl.uniprot.org/uniprot/A0A2R9BY33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/9597:FMO5 ^@ http://purl.uniprot.org/uniprot/A0A2R9AK06 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters.|||Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9597:ZNF135 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z708|||http://purl.uniprot.org/uniprot/A0A2R8ZAS0|||http://purl.uniprot.org/uniprot/A0A2R8ZD90 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:SLC27A5 ^@ http://purl.uniprot.org/uniprot/A0A2R9C256 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9597:LOC100988821 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZH37 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:SNX5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIM8|||http://purl.uniprot.org/uniprot/A0A2R8ZL06 ^@ Function|||Similarity ^@ Belongs to the sorting nexin family.|||Involved in several stages of intracellular trafficking. http://togogenome.org/gene/9597:LOC100993580 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1F7 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:MAP3K13 ^@ http://purl.uniprot.org/uniprot/A0A2R9AUE9 ^@ Function|||Similarity ^@ Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7.|||Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/9597:BID ^@ http://purl.uniprot.org/uniprot/A0A2R9A786 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2.|||Induces caspases and apoptosis. Counters the protective effect of BCL2.|||Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9597:SNRNP200 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7E7 ^@ Similarity ^@ Belongs to the helicase family. SKI2 subfamily. http://togogenome.org/gene/9597:RPL23A ^@ http://purl.uniprot.org/uniprot/A0A2R9A5I1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/9597:NGB ^@ http://purl.uniprot.org/uniprot/A0A2R9C3L3 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9597:DDO ^@ http://purl.uniprot.org/uniprot/A0A2R9B5I8|||http://purl.uniprot.org/uniprot/A0A2R9B716 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAMOX/DASOX family.|||Peroxisome http://togogenome.org/gene/9597:FAM114A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYV1 ^@ Similarity ^@ Belongs to the FAM114 family. http://togogenome.org/gene/9597:PRPF4B ^@ http://purl.uniprot.org/uniprot/A0A2R9BYC3 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.|||Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF. http://togogenome.org/gene/9597:AKR1E2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C2D6|||http://purl.uniprot.org/uniprot/A0A2R9C2E4 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9597:CFLAR ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTA9 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9597:HSD17B13 ^@ http://purl.uniprot.org/uniprot/A0A2R9CFD9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9597:LOC100992022 ^@ http://purl.uniprot.org/uniprot/A0A2R9B884 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:SPIN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A2A6 ^@ Similarity ^@ Belongs to the SPIN/STSY family. http://togogenome.org/gene/9597:SLC6A9 ^@ http://purl.uniprot.org/uniprot/A0A2R9CHG2|||http://purl.uniprot.org/uniprot/A0A2R9CR51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:GPR15 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKQ7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9597:ELF2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZG81|||http://purl.uniprot.org/uniprot/A0A2R8ZGN5|||http://purl.uniprot.org/uniprot/A0A2R8ZGP0|||http://purl.uniprot.org/uniprot/A0A2R8ZML2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9597:CEPT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CGQ3 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/9597:LOC100981066 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z963 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:CDCA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ARS7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:MTHFD1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEG2 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.|||In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. http://togogenome.org/gene/9597:ORMDL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C6X7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/9597:LOC100994024 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHV4 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:ORC6 ^@ http://purl.uniprot.org/uniprot/A0A2R9BQP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC6 family.|||Nucleus http://togogenome.org/gene/9597:CTSC ^@ http://purl.uniprot.org/uniprot/A0A2R9BWH9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C1 family.|||Lysosome|||Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains. http://togogenome.org/gene/9597:RNASET2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AMM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase T2 family.|||Lysosome lumen http://togogenome.org/gene/9597:AK6 ^@ http://purl.uniprot.org/uniprot/A0A2R9CGZ2|||http://purl.uniprot.org/uniprot/A0A2R9CJQ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.|||Cajal body|||Monomer and homodimer. Interacts with COIL (via C-terminus).|||nucleoplasm http://togogenome.org/gene/9597:LYRM2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BG06 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9597:ITGA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BDD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9597:UGT8 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEX4 ^@ Similarity ^@ Belongs to the UDP-glycosyltransferase family. http://togogenome.org/gene/9597:CLGN ^@ http://purl.uniprot.org/uniprot/A0A2R9BZR0 ^@ Similarity ^@ Belongs to the calreticulin family. http://togogenome.org/gene/9597:TFE3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A329 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/9597:LOC100980404 ^@ http://purl.uniprot.org/uniprot/A0A2R9C518 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase IV family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9597:STARD3NL ^@ http://purl.uniprot.org/uniprot/A0A2R9BSN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STARD3 family.|||Membrane http://togogenome.org/gene/9597:CRYAA ^@ http://purl.uniprot.org/uniprot/A0A2R9AZW0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.|||Nucleus http://togogenome.org/gene/9597:FUT8 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 23 family.|||Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9597:CHST3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C0K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/9597:EEIG2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BI51 ^@ Similarity ^@ Belongs to the EEIG family. http://togogenome.org/gene/9597:ZNF470 ^@ http://purl.uniprot.org/uniprot/A0A2R9C2R2 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:DCTPP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B350 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Homotetramer.|||Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.|||cytosol http://togogenome.org/gene/9597:ZPBP ^@ http://purl.uniprot.org/uniprot/A0A2R9AF12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the zona pellucida-binding protein Sp38 family.|||Secreted|||acrosome http://togogenome.org/gene/9597:FAM32A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZRV6 ^@ Similarity ^@ Belongs to the FAM32 family. http://togogenome.org/gene/9597:PARP3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C2I5|||http://purl.uniprot.org/uniprot/A0A2R9C302 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARTD/PARP family.|||Nucleus http://togogenome.org/gene/9597:REC8 ^@ http://purl.uniprot.org/uniprot/A0A2R9AFN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad21 family.|||Nucleus http://togogenome.org/gene/9597:RPS6KA5 ^@ http://purl.uniprot.org/uniprot/A0A2R9BP98 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9597:SLC25A32 ^@ http://purl.uniprot.org/uniprot/A0A2R9C2T3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9597:HEATR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HEATR1/UTP10 family.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/9597:CDK20 ^@ http://purl.uniprot.org/uniprot/A0A2R9BAB7|||http://purl.uniprot.org/uniprot/A0A2R9BBN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily.|||Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.|||cilium http://togogenome.org/gene/9597:BEX4 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z8F7 ^@ Similarity ^@ Belongs to the BEX family. http://togogenome.org/gene/9597:ATP6V1H ^@ http://purl.uniprot.org/uniprot/A0A2R9BM13|||http://purl.uniprot.org/uniprot/A0A2R9BQN8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase H subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9597:TMEM216 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFR4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:CYP1A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B5W8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9597:SET ^@ http://purl.uniprot.org/uniprot/A0A2R9A757 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9597:C22H22orf39 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJ26|||http://purl.uniprot.org/uniprot/A0A2R9AR96 ^@ Similarity ^@ Belongs to the UPF0545 family. http://togogenome.org/gene/9597:VPS37A ^@ http://purl.uniprot.org/uniprot/A0A2R9B4U7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9597:NDUFV2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ASJ9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. http://togogenome.org/gene/9597:RPL27A ^@ http://purl.uniprot.org/uniprot/A0A2R9A3H5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/9597:PUS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C3S2 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/9597:C7H7orf25 ^@ http://purl.uniprot.org/uniprot/A0A2R9C777 ^@ Similarity ^@ Belongs to the UPF0415 family. http://togogenome.org/gene/9597:MRFAP1L1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFY6 ^@ Similarity ^@ Belongs to the MORF4 family-associated protein family. http://togogenome.org/gene/9597:LOC100989841 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKC5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9597:DVL3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C8L5 ^@ Similarity ^@ Belongs to the DSH family. http://togogenome.org/gene/9597:PPARG ^@ http://purl.uniprot.org/uniprot/A0A2R9A3D9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Cytoplasm|||Heterodimer with other nuclear receptors.|||Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.|||Nucleus http://togogenome.org/gene/9597:SCGB1D2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCD0 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9597:KRT15 ^@ http://purl.uniprot.org/uniprot/A0A2R9C995 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9597:TOM1L2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNF3|||http://purl.uniprot.org/uniprot/A0A2R8ZRE5 ^@ Similarity ^@ Belongs to the TOM1 family. http://togogenome.org/gene/9597:ZNF551 ^@ http://purl.uniprot.org/uniprot/A0A2R9AIX6 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:ERCC4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BAH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPF family.|||Nucleus http://togogenome.org/gene/9597:HEXIM2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HEXIM family.|||Nucleus http://togogenome.org/gene/9597:THEMIS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AF64 ^@ Similarity ^@ Belongs to the themis family. http://togogenome.org/gene/9597:RPS11 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSU4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/9597:LIAS ^@ http://purl.uniprot.org/uniprot/A0A2R9C0M6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Mitochondrion http://togogenome.org/gene/9597:LOXL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AG59 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/9597:DDIT4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZU89 ^@ Similarity ^@ Belongs to the DDIT4 family. http://togogenome.org/gene/9597:GATC ^@ http://purl.uniprot.org/uniprot/A0A2R9A3N2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/9597:HCST ^@ http://purl.uniprot.org/uniprot/A0A2R9B2P6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAP10 family.|||Membrane http://togogenome.org/gene/9597:RNASE12 ^@ http://purl.uniprot.org/uniprot/A0A2R9AWY8 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9597:MDM2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQ86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM2/MDM4 family.|||Cytoplasm|||nucleolus|||nucleoplasm http://togogenome.org/gene/9597:TIMM10B ^@ http://purl.uniprot.org/uniprot/A0A2R9BXW4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9597:LOC100978488 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZN32 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:AMFR ^@ http://purl.uniprot.org/uniprot/A0A2R9CF69 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:NAP1L4 ^@ http://purl.uniprot.org/uniprot/A0A2R9ALN5|||http://purl.uniprot.org/uniprot/A0A2R9ALP1 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9597:CXCR2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:MAT2A ^@ http://purl.uniprot.org/uniprot/A0A2R9C4C8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/9597:LOC100988443 ^@ http://purl.uniprot.org/uniprot/A0A2R9BB48 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:CNTNAP5 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJA0 ^@ Caution|||Similarity ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:SRPRA ^@ http://purl.uniprot.org/uniprot/A0A2R9AEJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding SRP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:SPDL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BEM9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Spindly family.|||Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect.|||Nucleus|||Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.|||centrosome|||kinetochore|||spindle pole http://togogenome.org/gene/9597:TMOD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A154 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9597:DNAAF8 ^@ http://purl.uniprot.org/uniprot/A0A2R9C6N9 ^@ Function|||Subcellular Location Annotation ^@ Dynein axonemal particle|||In cyliated cells, dynein axonemal particle-specific protein required for deployment of ODA to the axoneme. Interacts with outer dynein arm (ODA) subunits. http://togogenome.org/gene/9597:FLCN ^@ http://purl.uniprot.org/uniprot/A0A2R9CNN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the folliculin family.|||Lysosome membrane|||Membrane|||Nucleus|||centrosome|||cilium|||cytosol|||spindle http://togogenome.org/gene/9597:IL4I1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BZW6 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/9597:CMAS ^@ http://purl.uniprot.org/uniprot/A0A2R9BYY4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CMP-NeuNAc synthase family.|||Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).|||Homotetramer; the active enzyme is formed by a dimer of dimers. http://togogenome.org/gene/9597:TMED7 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1N0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9597:SMU1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SMU1 family.|||Nucleus speckle http://togogenome.org/gene/9597:ISM2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AX37 ^@ Similarity ^@ Belongs to the isthmin family. http://togogenome.org/gene/9597:OTUB2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A3M9 ^@ Similarity ^@ Belongs to the peptidase C65 family. http://togogenome.org/gene/9597:AK1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AYN7 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK1 subfamily.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/9597:NCBP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BE18 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRM NCBP2 family.|||Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.|||Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.|||Nucleus http://togogenome.org/gene/9597:SPECC1L ^@ http://purl.uniprot.org/uniprot/A0A2R9AC63 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytospin-A family.|||Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.|||May interact with both microtubules and actin cytoskeleton.|||cytoskeleton|||gap junction|||spindle http://togogenome.org/gene/9597:TMEM17 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZC99 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:TNFSF13 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPT3|||http://purl.uniprot.org/uniprot/A0A2R8ZVN2 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9597:BLMH ^@ http://purl.uniprot.org/uniprot/A0A2R9B0W3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Cytoplasm http://togogenome.org/gene/9597:SORL1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUE8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS10-related sortilin family. SORL1 subfamily.|||Cell membrane|||Early endosome membrane|||Endoplasmic reticulum membrane|||Endosome membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Recycling endosome membrane|||Secreted|||multivesicular body membrane|||secretory vesicle membrane|||trans-Golgi network membrane http://togogenome.org/gene/9597:CIAO1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CNN0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the WD repeat CIA1 family.|||Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.|||Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. http://togogenome.org/gene/9597:FSCN3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CGH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fascin family.|||cytoskeleton http://togogenome.org/gene/9597:AQR ^@ http://purl.uniprot.org/uniprot/A0A2R9AK31 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CWF11 family.|||Identified in the spliceosome C complex. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE.|||Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.|||Nucleus http://togogenome.org/gene/9597:DIPK2B ^@ http://purl.uniprot.org/uniprot/A0A2R9BES5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Secreted http://togogenome.org/gene/9597:SEPTIN9 ^@ http://purl.uniprot.org/uniprot/A0A2R9B1S7|||http://purl.uniprot.org/uniprot/A0A2R9B211|||http://purl.uniprot.org/uniprot/A0A2R9B3S7|||http://purl.uniprot.org/uniprot/A0A2R9B5U0 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/9597:CTNND1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CFR2|||http://purl.uniprot.org/uniprot/A0A2R9CNM6 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/9597:ZNF480 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDR3 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:HOXB4 ^@ http://purl.uniprot.org/uniprot/A0A2R9C1W2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9597:MFAP5 ^@ http://purl.uniprot.org/uniprot/A0A2R9BT75|||http://purl.uniprot.org/uniprot/A0A2R9BT81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MFAP family.|||extracellular matrix http://togogenome.org/gene/9597:LOC100973205 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMZ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:LOC100972888 ^@ http://purl.uniprot.org/uniprot/A0A2R9AY07 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/9597:PTPN22 ^@ http://purl.uniprot.org/uniprot/A0A2R9B9T0 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. http://togogenome.org/gene/9597:SLC4A2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJA6 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:QRSL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ADE5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/9597:PSME4 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9E5 ^@ Similarity ^@ Belongs to the BLM10 family. http://togogenome.org/gene/9597:IL33 ^@ http://purl.uniprot.org/uniprot/A0A2R9A3H2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family. Highly divergent.|||Chromosome|||Nucleus|||Secreted|||Vesicle|||secretory vesicle http://togogenome.org/gene/9597:ALAS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CAD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:ZNF132 ^@ http://purl.uniprot.org/uniprot/A0A2R9C8I9 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:FLI1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C1G7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9597:DPM2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CL82 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPM2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum membrane|||Membrane|||Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. http://togogenome.org/gene/9597:COPS6 ^@ http://purl.uniprot.org/uniprot/A0A2R9CNJ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M67A family. CSN6 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:GLB1L ^@ http://purl.uniprot.org/uniprot/A0A2R9BEV6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 35 family. http://togogenome.org/gene/9597:ETNPPL ^@ http://purl.uniprot.org/uniprot/A0A2R9AQ91 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9597:STK32A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYM2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:GPNMB ^@ http://purl.uniprot.org/uniprot/A0A2R9AQ34 ^@ Similarity ^@ Belongs to the PMEL/NMB family. http://togogenome.org/gene/9597:DOK3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AEB1 ^@ Similarity ^@ Belongs to the DOK family. Type A subfamily. http://togogenome.org/gene/9597:INHBE ^@ http://purl.uniprot.org/uniprot/A0A2R9CQH3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/9597:FUCA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BGD3 ^@ Function|||Similarity|||Subunit ^@ Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.|||Belongs to the glycosyl hydrolase 29 family.|||Homotetramer. http://togogenome.org/gene/9597:TOB1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZD48 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9597:TAS1R3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B4E3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:MED10 ^@ http://purl.uniprot.org/uniprot/A0A2R9ALB0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 10 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9597:USO1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VDP/USO1/EDE1 family.|||Membrane http://togogenome.org/gene/9597:BMP4 ^@ http://purl.uniprot.org/uniprot/A0A2R9A169 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9597:TMEM14A ^@ http://purl.uniprot.org/uniprot/A0A2R9B801 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/9597:TMEM120A ^@ http://purl.uniprot.org/uniprot/A0A2R9B2S8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM120 family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/9597:ETFA ^@ http://purl.uniprot.org/uniprot/A0A2R9BWF3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ETF alpha-subunit/FixB family.|||Binds 1 FAD per dimer.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion matrix|||The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). http://togogenome.org/gene/9597:TMEM138 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z879 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM138 family.|||Membrane|||Required for ciliogenesis.|||Vacuole membrane|||cilium http://togogenome.org/gene/9597:POLR3GL ^@ http://purl.uniprot.org/uniprot/A0A2R9AY48 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPC7 RNA polymerase subunit family.|||Component of the RNA polymerase III (Pol III) complex.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/9597:APPL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BK75 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Endosome membrane|||Membrane|||Nucleus|||phagosome|||ruffle http://togogenome.org/gene/9597:LOC100968447 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZB01 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:GPR161 ^@ http://purl.uniprot.org/uniprot/A0A2R9A4J3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9597:ESX1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPQ1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:HR ^@ http://purl.uniprot.org/uniprot/A0A2R9APB1|||http://purl.uniprot.org/uniprot/A0A2R9AVM6 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the JHDM2 histone demethylase family.|||Binds 1 Fe(2+) ion per subunit.|||Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.|||Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.|||Nucleus|||The JmjC domain and the C6-type zinc-finger are required for the demethylation activity. http://togogenome.org/gene/9597:HS2ST1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 3 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:MED29 ^@ http://purl.uniprot.org/uniprot/A0A2R9BE52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 29 family.|||Nucleus http://togogenome.org/gene/9597:HKDC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B419 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/9597:SCAI ^@ http://purl.uniprot.org/uniprot/A0A2R9B9Q3|||http://purl.uniprot.org/uniprot/A0A2R9BD35 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCAI family.|||Cytoplasm|||Interacts with DIAPH1. Forms a nuclear ternary complex with MRTFA and SRF.|||Nucleus|||Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity. http://togogenome.org/gene/9597:EIF5 ^@ http://purl.uniprot.org/uniprot/A0A2R9BWK1 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/9597:PELI1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CTL4 ^@ Function|||Similarity ^@ Belongs to the pellino family.|||E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. http://togogenome.org/gene/9597:SPR ^@ http://purl.uniprot.org/uniprot/A0A2R9BYA7 ^@ Similarity ^@ Belongs to the sepiapterin reductase family. http://togogenome.org/gene/9597:KIF23 ^@ http://purl.uniprot.org/uniprot/A0A2R9BM71|||http://purl.uniprot.org/uniprot/A0A2R9BVE2 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9597:NEU4 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z5M6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/9597:CCDC153 ^@ http://purl.uniprot.org/uniprot/A0A2R9BL48 ^@ Similarity ^@ Belongs to the UPF0610 family. http://togogenome.org/gene/9597:SLC5A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:RUVBL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYI0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RuvB family.|||Dynein axonemal particle|||Nucleus|||Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. http://togogenome.org/gene/9597:ELK1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CFX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9597:TMEM50A ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane http://togogenome.org/gene/9597:VASN ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7P3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:TTC38 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZN90 ^@ Similarity ^@ Belongs to the TTC38 family. http://togogenome.org/gene/9597:LOC100984482 ^@ http://purl.uniprot.org/uniprot/A0A2R9BFV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMN family.|||Cajal body|||Perikaryon|||Z line|||gem|||neuron projection http://togogenome.org/gene/9597:LOC100996035 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUL1 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9597:GCFC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7L6 ^@ Similarity ^@ Belongs to the GCF family. http://togogenome.org/gene/9597:TMEM200A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM200 family.|||Membrane http://togogenome.org/gene/9597:DCAF11 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTA7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the WD repeat LEC14B family.|||Interacts with DDB1 and CUL4A.|||May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. http://togogenome.org/gene/9597:MRPS12 ^@ http://purl.uniprot.org/uniprot/A0A2R9CA13 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS12 family. http://togogenome.org/gene/9597:SLC27A3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJU9 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9597:MNAT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B0C8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with CDK7 and cyclin H.|||Nucleus|||Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. http://togogenome.org/gene/9597:LOC100990258 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYL4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase F subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9597:TRIM32 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPX3 ^@ Similarity ^@ Belongs to the TRIM/RBCC family. http://togogenome.org/gene/9597:GPAT4 ^@ http://purl.uniprot.org/uniprot/A0A2R9A7F5 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9597:CBX8 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1E3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:DNAAF6 ^@ http://purl.uniprot.org/uniprot/A0A2R9CAC2 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/9597:EXT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C8P8|||http://purl.uniprot.org/uniprot/A0A2R9CGJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:FGF23 ^@ http://purl.uniprot.org/uniprot/A0A2R9AWI6 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9597:CXCL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BNX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9597:LOC100981375 ^@ http://purl.uniprot.org/uniprot/A0A2R9AUL5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:LEP ^@ http://purl.uniprot.org/uniprot/A0A2R9B6N0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the leptin family.|||Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways. May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells. Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 wich promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38. In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses. Increases CD4(+)CD25(-) T-cell proliferation and reduces autophagy during TCR (T-cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation.|||Secreted http://togogenome.org/gene/9597:STRADA ^@ http://purl.uniprot.org/uniprot/A0A2R9A6A2|||http://purl.uniprot.org/uniprot/A0A2R9A7H1 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. http://togogenome.org/gene/9597:SLC17A6 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACE7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:GABRG1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1L5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9597:AFF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A544 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/9597:LOC100985834 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIY0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:SDHAF4 ^@ http://purl.uniprot.org/uniprot/A0A2R9ALB3 ^@ Similarity ^@ Belongs to the SDHAF4 family. http://togogenome.org/gene/9597:RPS15A ^@ http://purl.uniprot.org/uniprot/A0A2R9ALI7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS8 family. http://togogenome.org/gene/9597:LOC100977118 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZW54 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/9597:ABCC9 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZ28 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with KCNJ11.|||Membrane http://togogenome.org/gene/9597:RPLP2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZWV3 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/9597:PLN ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJ06 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phospholamban family.|||Endoplasmic reticulum membrane|||Homopentamer.|||Membrane|||Mitochondrion membrane|||Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/9597:CD52 ^@ http://purl.uniprot.org/uniprot/A0A2R9BPG1 ^@ Function|||Subcellular Location Annotation ^@ May play a role in carrying and orienting carbohydrate, as well as having a more specific role.|||Membrane http://togogenome.org/gene/9597:MRPL33 ^@ http://purl.uniprot.org/uniprot/A0A2R9AMU4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/9597:GOLM1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLM family.|||Membrane http://togogenome.org/gene/9597:LOC100990880 ^@ http://purl.uniprot.org/uniprot/A0A2R9B3Y8 ^@ Similarity ^@ Belongs to the UQCC4 family. http://togogenome.org/gene/9597:PROK1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AVIT (prokineticin) family.|||Secreted http://togogenome.org/gene/9597:PITHD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AD35 ^@ Similarity ^@ Belongs to the PITHD1 family. http://togogenome.org/gene/9597:INTS10 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 10 family.|||Nucleus http://togogenome.org/gene/9597:TMEM35B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZD25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Membrane http://togogenome.org/gene/9597:ST13 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7Y4 ^@ Similarity ^@ Belongs to the FAM10 family. http://togogenome.org/gene/9597:BCO2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4N2 ^@ Cofactor|||Similarity ^@ Belongs to the carotenoid oxygenase family.|||Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/9597:KLC4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQJ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kinesin light chain family.|||Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.|||Oligomeric complex composed of two heavy chains and two light chains.|||cytoskeleton http://togogenome.org/gene/9597:CD68 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTV8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9597:DNAL4 ^@ http://purl.uniprot.org/uniprot/A0A2R9APM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/9597:DOP1A ^@ http://purl.uniprot.org/uniprot/A0A2R9CE30|||http://purl.uniprot.org/uniprot/A0A2R9CM96 ^@ Similarity ^@ Belongs to the dopey family. http://togogenome.org/gene/9597:PAX4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AS32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/9597:CSF3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJQ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-6 superfamily.|||Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.|||Secreted http://togogenome.org/gene/9597:TOMM40L ^@ http://purl.uniprot.org/uniprot/A0A2R9C7B2|||http://purl.uniprot.org/uniprot/A0A2R9C7B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom40 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9597:RXFP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CC12 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:NECAP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CPP5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NECAP family.|||Involved in endocytosis.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9597:KCNE3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZR49 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/9597:SUCLA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BKF1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.|||Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.|||Mitochondrion http://togogenome.org/gene/9597:LIPG ^@ http://purl.uniprot.org/uniprot/A0A2R9B1A7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9597:HTR1E ^@ http://purl.uniprot.org/uniprot/A0A2R8ZA08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:ALDH3A2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXA2|||http://purl.uniprot.org/uniprot/A0A2R9AZE0 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9597:EPOR ^@ http://purl.uniprot.org/uniprot/A0A2R9AWD4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||Forms homodimers on EPO stimulation.|||Membrane|||Receptor for erythropoietin. http://togogenome.org/gene/9597:LOC100987845 ^@ http://purl.uniprot.org/uniprot/A0A2R9A3S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CIBAR family.|||centriole|||cilium basal body http://togogenome.org/gene/9597:SOAT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9S9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:MRC2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZ20 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:RNF13 ^@ http://purl.uniprot.org/uniprot/A0A2R9BEY4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:KLHL40 ^@ http://purl.uniprot.org/uniprot/A0A2R9CTD9 ^@ Similarity|||Subcellular Location Annotation ^@ A band|||Belongs to the KLHL40 family.|||I band http://togogenome.org/gene/9597:BBS7 ^@ http://purl.uniprot.org/uniprot/A0A2R9A8B3 ^@ Function|||Subunit ^@ Part of BBSome complex.|||The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. http://togogenome.org/gene/9597:ZSCAN25 ^@ http://purl.uniprot.org/uniprot/A0A2R9CHA0 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9597:XYLB ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTH1 ^@ Function|||Similarity ^@ Belongs to the FGGY kinase family.|||Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis. http://togogenome.org/gene/9597:HBEGF ^@ http://purl.uniprot.org/uniprot/A0A2R9BV62 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:PLPPR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4A7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9597:LOC100976052 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNH1 ^@ Similarity ^@ Belongs to the CD200R family. http://togogenome.org/gene/9597:B3GNT5 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z615 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:UBE3D ^@ http://purl.uniprot.org/uniprot/A0A2R9C4M9 ^@ Function ^@ E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. http://togogenome.org/gene/9597:SMC1B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC1 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/9597:ENO1 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7M2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/9597:UBAP2L ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDM8|||http://purl.uniprot.org/uniprot/A0A2R8ZDN9|||http://purl.uniprot.org/uniprot/A0A2R8ZDP0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:PMP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A080 ^@ Function|||Similarity|||Subunit ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||May play a role in lipid transport protein in Schwann cells. May bind cholesterol.|||Monomer. http://togogenome.org/gene/9597:EPO ^@ http://purl.uniprot.org/uniprot/A0A2R9CD53 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPO/TPO family.|||Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.|||Secreted http://togogenome.org/gene/9597:FGF17 ^@ http://purl.uniprot.org/uniprot/A0A2R9CFH6 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9597:CSN3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B910 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the kappa-casein family.|||Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.|||Secreted http://togogenome.org/gene/9597:MLLT3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZRG2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:FAM234B ^@ http://purl.uniprot.org/uniprot/A0A2R9CBW9 ^@ Similarity ^@ Belongs to the FAM234 family. http://togogenome.org/gene/9597:NKX2-3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B6R3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:CNTNAP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9Y5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||paranodal septate junction http://togogenome.org/gene/9597:IL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACE1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-2 family.|||Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.|||Secreted http://togogenome.org/gene/9597:LOC100980448 ^@ http://purl.uniprot.org/uniprot/A0A2R9A5J7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin family.|||cytoskeleton http://togogenome.org/gene/9597:RBBP7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BC22 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:MRPL11 ^@ http://purl.uniprot.org/uniprot/A0A2R9A3R3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL11 family. http://togogenome.org/gene/9597:FMO2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B464 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9597:SLC25A44 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZWJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9597:RFC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9P3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the activator 1 large subunit family.|||Nucleus http://togogenome.org/gene/9597:OSTC ^@ http://purl.uniprot.org/uniprot/A0A2R9CSU8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OSTC family.|||Component of the oligosaccharyltransferase (OST) complex.|||Membrane|||Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1. http://togogenome.org/gene/9597:TOMM22 ^@ http://purl.uniprot.org/uniprot/A0A2R9AR74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom22 family.|||Mitochondrion outer membrane http://togogenome.org/gene/9597:RPL24 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIX4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/9597:TM6SF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4W8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TM6SF family.|||Membrane http://togogenome.org/gene/9597:SIX6 ^@ http://purl.uniprot.org/uniprot/A0A2R9CLP7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:TMEM39B ^@ http://purl.uniprot.org/uniprot/A0A2R9AFI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM39 family.|||Membrane http://togogenome.org/gene/9597:DNAJC10 ^@ http://purl.uniprot.org/uniprot/A0A2R9C0F0 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9597:POLG ^@ http://purl.uniprot.org/uniprot/A0A2R9CIN0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DNA polymerase type-A family.|||Heterotrimer composed of a catalytic subunit and a homodimer of accessory subunits.|||Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA.|||mitochondrion nucleoid http://togogenome.org/gene/9597:LOC100992158 ^@ http://purl.uniprot.org/uniprot/A0A2R9C257 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.|||Belongs to the universal ribosomal protein uS2 family.|||Cell membrane|||Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.|||Cytoplasm|||Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.|||Nucleus|||Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.|||This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. http://togogenome.org/gene/9597:MSRB3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B061 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Binds 1 zinc ion per subunit.|||Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. http://togogenome.org/gene/9597:TSEN34 ^@ http://purl.uniprot.org/uniprot/A0A2R9BDN0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA-intron endonuclease family.|||Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.|||Nucleus http://togogenome.org/gene/9597:CENPK ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-K/MCM22 family.|||Nucleus|||centromere http://togogenome.org/gene/9597:GLI1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CQM3 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/9597:ENPP3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBQ0 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9597:LALBA ^@ http://purl.uniprot.org/uniprot/A0A2R9ACU0 ^@ Function|||Similarity ^@ Belongs to the glycosyl hydrolase 22 family.|||Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins. http://togogenome.org/gene/9597:OXER1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIX0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9597:CD79B ^@ http://purl.uniprot.org/uniprot/A0A2R9C3B1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:JPH1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AM33 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the junctophilin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.|||Membrane http://togogenome.org/gene/9597:CLSPN ^@ http://purl.uniprot.org/uniprot/A0A2R9A3S2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:KEAP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BRR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KEAP1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:LOC100984084 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHH0 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:PANX3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A6D7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Structural component of the gap junctions and the hemichannels.|||gap junction http://togogenome.org/gene/9597:DYNLRB2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZV49 ^@ Similarity ^@ Belongs to the GAMAD family. http://togogenome.org/gene/9597:PEA15 ^@ http://purl.uniprot.org/uniprot/A0A2R9A7G9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:SIAH3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AIW9 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/9597:SLC19A2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CL39 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.|||Cell membrane|||High-affinity transporter for the intake of thiamine. http://togogenome.org/gene/9597:GRM3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BG51 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.|||Interacts with TAMALIN.|||Membrane http://togogenome.org/gene/9597:C18H18orf32 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZU84 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UPF0729 family.|||Interacts with DERL1 and AMFR.|||Lipid droplet|||May activate the NF-kappa-B signaling pathway. http://togogenome.org/gene/9597:MTO1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A193|||http://purl.uniprot.org/uniprot/A0A2R9A5L3 ^@ Function|||Similarity ^@ Belongs to the MnmG family.|||Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. http://togogenome.org/gene/9597:LOC100980884 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z8L0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:ALPP ^@ http://purl.uniprot.org/uniprot/A0A2R9BU96 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alkaline phosphatase family.|||Binds 1 Mg(2+) ion.|||Binds 2 Zn(2+) ions.|||Cell membrane|||Homodimer.|||Membrane http://togogenome.org/gene/9597:SLC27A2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CFT6|||http://purl.uniprot.org/uniprot/A0A2R9CIF1 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9597:RGS14 ^@ http://purl.uniprot.org/uniprot/A0A2R9AP20 ^@ Subcellular Location Annotation ^@ dendrite http://togogenome.org/gene/9597:MAPK1IP1L ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYD7 ^@ Similarity ^@ Belongs to the MISS family. http://togogenome.org/gene/9597:ARGLU1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACG3 ^@ Similarity ^@ Belongs to the UPF0430 family. http://togogenome.org/gene/9597:CALR ^@ http://purl.uniprot.org/uniprot/A0A2R8Z933 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calreticulin family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9597:SLC31A2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CTC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9597:ATG7 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9V9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG7 family.|||Cytoplasm|||E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress.|||Homodimer.|||Preautophagosomal structure http://togogenome.org/gene/9597:SS18L2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZX6 ^@ Similarity ^@ Belongs to the SS18 family. http://togogenome.org/gene/9597:MFSD6L ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. MFSD6 family.|||Membrane http://togogenome.org/gene/9597:TOMM40 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom40 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9597:CPNE3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A005 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9597:NR2C1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CK29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9597:APOL6 ^@ http://purl.uniprot.org/uniprot/A0A2R9BVD4 ^@ Similarity ^@ Belongs to the apolipoprotein L family. http://togogenome.org/gene/9597:HSPB7 ^@ http://purl.uniprot.org/uniprot/A0A2R9AL15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Nucleus http://togogenome.org/gene/9597:PRKCI ^@ http://purl.uniprot.org/uniprot/A0A2R9B127 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cytoplasm http://togogenome.org/gene/9597:IFI44 ^@ http://purl.uniprot.org/uniprot/A0A2R9CQT3 ^@ Similarity ^@ Belongs to the IFI44 family. http://togogenome.org/gene/9597:ITIH1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9J6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/9597:SLC25A34 ^@ http://purl.uniprot.org/uniprot/A0A2R9CBL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9597:SNX33 ^@ http://purl.uniprot.org/uniprot/A0A2R9CCK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane http://togogenome.org/gene/9597:POMT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AB99 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/9597:C6 ^@ http://purl.uniprot.org/uniprot/A0A2R9B8Y5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complement C6/C7/C8/C9 family.|||Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and 12-14 copies of the pore-forming subunit C9.|||Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9597:TMEFF2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAT1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:KHDC1L ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQ44 ^@ Similarity ^@ Belongs to the KHDC1 family. http://togogenome.org/gene/9597:TNFRSF19 ^@ http://purl.uniprot.org/uniprot/A0A2R9ANY2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:TAF12 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZV65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF12 family.|||Nucleus http://togogenome.org/gene/9597:PPP1R10 ^@ http://purl.uniprot.org/uniprot/A0A2R9BPN9 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers. http://togogenome.org/gene/9597:RETREG3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CEP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RETREG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:ATP6V0D2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AWS1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9597:TBX15 ^@ http://purl.uniprot.org/uniprot/A0A2R9B7V9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9597:SLC25A35 ^@ http://purl.uniprot.org/uniprot/A0A2R9AUY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9597:TYK2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C1D6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. http://togogenome.org/gene/9597:STC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CC17 ^@ Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9597:CD37 ^@ http://purl.uniprot.org/uniprot/A0A2R9BM06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9597:DHRS3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CHQ5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9597:MX2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AMN8 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/9597:ATP1A4 ^@ http://purl.uniprot.org/uniprot/A0A2R9A102 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:MPEG1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MPEG1 family.|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/9597:PRDM10 ^@ http://purl.uniprot.org/uniprot/A0A2R9CFJ6 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9597:GOLT1A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZS45 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||May be involved in fusion of ER-derived transport vesicles with the Golgi complex.|||Membrane http://togogenome.org/gene/9597:TAS2R7 ^@ http://purl.uniprot.org/uniprot/Q646D6 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).|||Membrane|||Several bitter taste receptors are expressed in a single taste receptor cell. http://togogenome.org/gene/9597:CER1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BLX9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9597:SUGP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BII1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:NPAS4 ^@ http://purl.uniprot.org/uniprot/A0A2R9B797 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:TRAPPC6A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||cis-Golgi network http://togogenome.org/gene/9597:TMEM225B ^@ http://purl.uniprot.org/uniprot/A0A2R9C3T4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:S100B ^@ http://purl.uniprot.org/uniprot/A0A2R9ADJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the S-100 family.|||Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/9597:KCNH3 ^@ http://purl.uniprot.org/uniprot/A0A2R9ANM2 ^@ Subcellular Location Annotation|||Subunit ^@ Membrane|||The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. http://togogenome.org/gene/9597:ZNF333 ^@ http://purl.uniprot.org/uniprot/A0A2R9A239 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:ABCD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C0A2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9597:ELP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZU92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELP1/IKA1 family.|||Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:TTYH2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A8B4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tweety family.|||Cell membrane|||Membrane|||Probable chloride channel. http://togogenome.org/gene/9597:LOC100982405 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCY2 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:CSK ^@ http://purl.uniprot.org/uniprot/A0A2R9A3Q5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9597:PAPSS2 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6U3 ^@ Similarity ^@ In the C-terminal section; belongs to the sulfate adenylyltransferase family.|||In the N-terminal section; belongs to the APS kinase family. http://togogenome.org/gene/9597:LOC100983778 ^@ http://purl.uniprot.org/uniprot/A8HDH0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/9597:CCS ^@ http://purl.uniprot.org/uniprot/A0A2R9AT42 ^@ Similarity ^@ In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family. http://togogenome.org/gene/9597:ABRAXAS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AK64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM175 family. Abro1 subfamily.|||Nucleus|||spindle pole http://togogenome.org/gene/9597:TLR4 ^@ http://purl.uniprot.org/uniprot/B3Y628 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9597:AP2B1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AN06|||http://purl.uniprot.org/uniprot/A0A2R9AN11 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/9597:CXCL11 ^@ http://purl.uniprot.org/uniprot/A0A2R9AGS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9597:LOC100991696 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLH9 ^@ Similarity|||Subunit ^@ Belongs to the GST superfamily. Theta family.|||Homodimer. http://togogenome.org/gene/9597:CAP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AT50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAP family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:PSMF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B9F3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the proteasome inhibitor PI31 family.|||Cytoplasm|||Endoplasmic reticulum|||Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28. http://togogenome.org/gene/9597:PPP2R5E ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLW4 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9597:IRF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B110 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Nucleus http://togogenome.org/gene/9597:USP20 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJ76 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family. USP20/USP33 subfamily.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||centrosome|||perinuclear region http://togogenome.org/gene/9597:KRT222 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTS0 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9597:SLC10A6 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9D4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/9597:ZNF330 ^@ http://purl.uniprot.org/uniprot/A0A2R9C733 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOA36 family.|||centromere|||nucleolus http://togogenome.org/gene/9597:AOC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BA23 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the copper/topaquinone oxidase family.|||Contains 1 topaquinone per subunit.|||Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. http://togogenome.org/gene/9597:HDAC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AS16 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.|||Nucleus http://togogenome.org/gene/9597:NFE2L2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BKQ1 ^@ Similarity ^@ Belongs to the bZIP family. CNC subfamily. http://togogenome.org/gene/9597:ATG16L2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CA16 ^@ Similarity ^@ Belongs to the WD repeat ATG16 family. http://togogenome.org/gene/9597:PMM2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C751 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic PMM family.|||Cytoplasm|||Homodimer.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/9597:ZFP30 ^@ http://purl.uniprot.org/uniprot/A0A2R9AKC8 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:ISCU ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZT4 ^@ Function|||Similarity ^@ Belongs to the NifU family.|||Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5. Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form. May modulate NFS1 desulfurase activity in a zinc-dependent manner. Modulates the interaction between FXN and the cysteine desulfurase complex. http://togogenome.org/gene/9597:BLCAP ^@ http://purl.uniprot.org/uniprot/A0A2R8ZG41 ^@ Function|||Similarity ^@ Belongs to the BLCAP family.|||May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B. http://togogenome.org/gene/9597:PLA2G4F ^@ http://purl.uniprot.org/uniprot/A0A2R9AYX5 ^@ Domain|||Subcellular Location Annotation ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding.|||cytosol http://togogenome.org/gene/9597:PKM ^@ http://purl.uniprot.org/uniprot/A0A2R9C424|||http://purl.uniprot.org/uniprot/A0A2R9CED5 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/9597:MEF2A ^@ http://purl.uniprot.org/uniprot/A0A2R9B3E7|||http://purl.uniprot.org/uniprot/A0A2R9B3G6|||http://purl.uniprot.org/uniprot/A0A2R9BA52 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:TMBIM6 ^@ http://purl.uniprot.org/uniprot/A0A2R9B016 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9597:SOAT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BQK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:CTNNA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vinculin/alpha-catenin family.|||Cell membrane|||Membrane|||adherens junction http://togogenome.org/gene/9597:ACSL4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AT86 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9597:KIF15 ^@ http://purl.uniprot.org/uniprot/A0A2R9B9F4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-12 subfamily.|||spindle http://togogenome.org/gene/9597:GPC4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BDY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/9597:OPTN ^@ http://purl.uniprot.org/uniprot/A0A2R9BNA4 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Golgi apparatus|||May act by regulating membrane trafficking and cellular morphogenesis.|||Recycling endosome|||autophagosome|||perinuclear region|||trans-Golgi network http://togogenome.org/gene/9597:TMBIM4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9597:MAS1 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7J2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9597:LYRM4 ^@ http://purl.uniprot.org/uniprot/A0A2R9A3H3 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9597:RPAP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BAV3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD.|||Belongs to the RPAP2 family.|||Nucleus|||Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes. http://togogenome.org/gene/9597:LOC100993258 ^@ http://purl.uniprot.org/uniprot/A0A2R9AM66 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:TRIAP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9I0 ^@ Similarity ^@ Belongs to the TRIAP1/MDM35 family. http://togogenome.org/gene/9597:UNK ^@ http://purl.uniprot.org/uniprot/A0A2R9APG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unkempt family.|||Cytoplasm http://togogenome.org/gene/9597:H1-2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9597:TMCO3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B7P5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:CTH ^@ http://purl.uniprot.org/uniprot/A0A2R9AB45 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/9597:TEKT3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B626 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/9597:PABIR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCM8 ^@ Similarity ^@ Belongs to the FAM122 family. http://togogenome.org/gene/9597:INPP5D ^@ http://purl.uniprot.org/uniprot/A0A2R9AEZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.|||Membrane http://togogenome.org/gene/9597:PDRG1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A910 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.|||Cytoplasm|||May play a role in chaperone-mediated protein folding. http://togogenome.org/gene/9597:DNAJB14 ^@ http://purl.uniprot.org/uniprot/A0A2R9B0H0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:ANG ^@ http://purl.uniprot.org/uniprot/A0A2R9AQ17 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9597:SLITRK5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZM48 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9597:CFAP68 ^@ http://purl.uniprot.org/uniprot/A0A2R9AP44 ^@ Function|||Subcellular Location Annotation ^@ Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.|||cilium axoneme http://togogenome.org/gene/9597:CNOT1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT1 family.|||Nucleus http://togogenome.org/gene/9597:SLC46A3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B8A4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:ARL6IP5 ^@ http://purl.uniprot.org/uniprot/A0A2R9AYA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/9597:CLCN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ALT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:SYP ^@ http://purl.uniprot.org/uniprot/A0A2R9AYF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/9597:CAPZA3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLK0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/9597:UBL3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZU73 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:STRA6 ^@ http://purl.uniprot.org/uniprot/A0A2R9B7F3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:CDKN2AIP ^@ http://purl.uniprot.org/uniprot/A0A2R9BXZ8 ^@ Similarity ^@ Belongs to the CARF family. http://togogenome.org/gene/9597:RPS6KA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BPU4|||http://purl.uniprot.org/uniprot/A0A2R9BYY6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9597:DGKZ ^@ http://purl.uniprot.org/uniprot/A0A2R9BS78|||http://purl.uniprot.org/uniprot/A0A2R9BSA8 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/9597:CZIB ^@ http://purl.uniprot.org/uniprot/A0A2R9BU24 ^@ Similarity ^@ Belongs to the UPF0587 family. http://togogenome.org/gene/9597:GSDMB ^@ http://purl.uniprot.org/uniprot/A0A2R9C0Q1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gasdermin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:CHRNG ^@ http://purl.uniprot.org/uniprot/A0A2R9CRT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9597:HAP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZXS7|||http://purl.uniprot.org/uniprot/A0A2R8ZYW3 ^@ Subcellular Location Annotation ^@ Early endosome|||Mitochondrion http://togogenome.org/gene/9597:POLR1E ^@ http://purl.uniprot.org/uniprot/A0A2R9AZN3|||http://purl.uniprot.org/uniprot/A0A2R9B0X1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.|||nucleolus http://togogenome.org/gene/9597:SLITRK2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTJ6 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9597:POLR1A ^@ http://purl.uniprot.org/uniprot/A0A2R9CCE6 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta' chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/9597:IRAK2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BPE6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.|||Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.|||Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. http://togogenome.org/gene/9597:WDR46 ^@ http://purl.uniprot.org/uniprot/A0A2R9AB91 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9597:LOC100973658 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAQ6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL6 family. http://togogenome.org/gene/9597:TRAPPC11 ^@ http://purl.uniprot.org/uniprot/A0A2R9A614 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPPC11 family.|||Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.|||cis-Golgi network http://togogenome.org/gene/9597:GSTT2B ^@ http://purl.uniprot.org/uniprot/A0A2R9B3V8 ^@ Similarity|||Subunit ^@ Belongs to the GST superfamily. Theta family.|||Homodimer. http://togogenome.org/gene/9597:LOC100978482 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZP43 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9597:CPPED1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B663 ^@ Function|||Similarity ^@ Belongs to the metallophosphoesterase superfamily. CPPED1 family.|||Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes. http://togogenome.org/gene/9597:PYROXD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.|||sarcomere http://togogenome.org/gene/9597:RBM42 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJY1|||http://purl.uniprot.org/uniprot/A0A2R9BJZ8 ^@ Similarity ^@ Belongs to the RRM RBM42 family. http://togogenome.org/gene/9597:TLR2 ^@ http://purl.uniprot.org/uniprot/B3Y614 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Toll-like receptor family.|||Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (By similarity).|||Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12.|||Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.|||In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity.|||Interacts with LY96, TLR1 and TLR6 (via extracellular domain). TLR2 seems to exist in heterodimers with either TLR1 or TLR6 before stimulation by the ligand. The heterodimers form bigger oligomers in response to their corresponding ligands as well as further heterotypic associations with other receptors such as CD14 and/or CD36. Binds MYD88 (via TIR domain). Interacts with TICAM1. Interacts with CNPY3. Interacts with ATG16L1. Interacts with PPP1R11. Interacts with TICAM2. Interacts with TIRAP (By similarity).|||Membrane|||Membrane raft|||The ATG16L1-binding motif mediates interaction with ATG16L1.|||Ubiquitinated at Lys-754 by PPP1R11, leading to its degradation. Deubiquitinated by USP2.|||phagosome membrane http://togogenome.org/gene/9597:TCP11L2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C876 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/9597:PIN4 ^@ http://purl.uniprot.org/uniprot/A0A2R9B5P5 ^@ Similarity ^@ Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily. http://togogenome.org/gene/9597:ARFGEF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B2G6 ^@ Subcellular Location Annotation ^@ Golgi apparatus|||perinuclear region http://togogenome.org/gene/9597:SPSB3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKW4 ^@ Function|||Similarity ^@ Belongs to the SPSB family.|||May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/9597:FAM83B ^@ http://purl.uniprot.org/uniprot/A0A2R9A0A2 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9597:ST7 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZXR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ST7 family.|||Membrane http://togogenome.org/gene/9597:USP9X ^@ http://purl.uniprot.org/uniprot/A0A2R9BVD0 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/9597:CCDC65 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJ03 ^@ Subcellular Location Annotation ^@ flagellum axoneme http://togogenome.org/gene/9597:NKX6-2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A5N8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:PLXNB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BXJ1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the plexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:PDIA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A4R3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9597:BCAT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A4U2|||http://purl.uniprot.org/uniprot/A0A2R9A4U7 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9597:PLAU ^@ http://purl.uniprot.org/uniprot/A0A2R9B7X2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:CRYL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJ69 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/9597:PHYHIPL ^@ http://purl.uniprot.org/uniprot/A0A2R9BWY6 ^@ Similarity ^@ Belongs to the PHYHIP family. http://togogenome.org/gene/9597:SLC6A7 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9597:FBXO48 ^@ http://purl.uniprot.org/uniprot/A0A2R9AFG0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2.|||Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1. Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway. Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation. http://togogenome.org/gene/9597:PRPSAP2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZC92 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/9597:IMMP1L ^@ http://purl.uniprot.org/uniprot/A0A2R9CKA4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26 family.|||Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.|||Heterodimer of 2 subunits, IMMPL1 and IMMPL2.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:ST6GALNAC5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9597:DNAJB12 ^@ http://purl.uniprot.org/uniprot/A0A2R9BHL0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:PDIA3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9597:LOC100978613 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCD5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.|||Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/9597:LOC100988094 ^@ http://purl.uniprot.org/uniprot/B0VYX2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 5A family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Interacts with AFG1L (By similarity). Interacts with RAB5IF (By similarity).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:SLC18A2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZND4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:WNT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AB51 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9597:CSF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4M7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GM-CSF family.|||Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.|||Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.|||Secreted http://togogenome.org/gene/9597:CADM3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CIJ2|||http://purl.uniprot.org/uniprot/A0A2R9CL84 ^@ Similarity ^@ Belongs to the nectin family. http://togogenome.org/gene/9597:CD5 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYS6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:CBX1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AGT2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:SPTSSB ^@ http://purl.uniprot.org/uniprot/A0A2R8ZA07 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:ZKSCAN5 ^@ http://purl.uniprot.org/uniprot/A0A2R9B6Z1 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9597:ACE ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYP1 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M2 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9597:ANXA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CNI1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||Membrane|||basement membrane http://togogenome.org/gene/9597:CACHD1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDU7 ^@ Similarity ^@ Belongs to the calcium channel subunit alpha-2/delta family. http://togogenome.org/gene/9597:KIF12 ^@ http://purl.uniprot.org/uniprot/A0A2R9C130 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9597:DEFB126 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSS3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9597:KIF11 ^@ http://purl.uniprot.org/uniprot/A0A2R9CQJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.|||spindle pole http://togogenome.org/gene/9597:PPP2R5C ^@ http://purl.uniprot.org/uniprot/A0A2R9BML8|||http://purl.uniprot.org/uniprot/A0A2R9BNF8 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9597:HSD17B4 ^@ http://purl.uniprot.org/uniprot/A0A2R9C8G1|||http://purl.uniprot.org/uniprot/A0A2R9CB89 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/9597:LOC100987402 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUA2 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:PEX3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZY46 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with PEX19.|||Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.|||Peroxisome membrane http://togogenome.org/gene/9597:FAR2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUJ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acyl-CoA reductase family.|||Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.|||Peroxisome membrane http://togogenome.org/gene/9597:RAB43 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane http://togogenome.org/gene/9597:CLDN34 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZI17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9597:PPP1R3B ^@ http://purl.uniprot.org/uniprot/A0A2R9AP01 ^@ Subunit ^@ Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity. http://togogenome.org/gene/9597:OPN1SW ^@ http://purl.uniprot.org/uniprot/P60573 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Cell membrane|||Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.|||Photoreceptor inner segment|||Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal (By similarity). Required for the maintenance of cone outer segment organization in the ventral retina, but not essential for the maintenance of functioning cone photoreceptors (By similarity). Involved in ensuring correct abundance and localization of retinal membrane proteins (By similarity). May increase spectral sensitivity in dim light (By similarity).|||perinuclear region|||photoreceptor outer segment http://togogenome.org/gene/9597:SATB2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CTC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/9597:FAM241B ^@ http://purl.uniprot.org/uniprot/A0A2R9B1J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM241 family.|||Membrane http://togogenome.org/gene/9597:LIPK ^@ http://purl.uniprot.org/uniprot/A0A2R9AIS3 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9597:EIF3H ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9B3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit H family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm http://togogenome.org/gene/9597:TSPAN4 ^@ http://purl.uniprot.org/uniprot/A0A2R9B448 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9597:AGMAT ^@ http://purl.uniprot.org/uniprot/A0A2R9A166 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/9597:PKP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZE41 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/9597:ASPN ^@ http://purl.uniprot.org/uniprot/A0A2R9B818 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||extracellular matrix http://togogenome.org/gene/9597:STAC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ADP0 ^@ Subcellular Location Annotation ^@ sarcolemma http://togogenome.org/gene/9597:AREG ^@ http://purl.uniprot.org/uniprot/A0A2R9CBP5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:HTR6 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAV3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9597:MYO1C ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVX3 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9597:MED24 ^@ http://purl.uniprot.org/uniprot/A0A2R9AK79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 24 family.|||Nucleus http://togogenome.org/gene/9597:BDNF ^@ http://purl.uniprot.org/uniprot/A0A2R9A467 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NGF-beta family.|||During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.|||Monomers and homodimers. Binds to NTRK2/TRKB.|||Secreted http://togogenome.org/gene/9597:CA8 ^@ http://purl.uniprot.org/uniprot/A0A2R9BI01 ^@ Similarity ^@ Belongs to the alpha-carbonic anhydrase family. http://togogenome.org/gene/9597:LDHC ^@ http://purl.uniprot.org/uniprot/A0A2R9BKE8|||http://purl.uniprot.org/uniprot/A0A2R9BUA1 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/9597:RPL13A ^@ http://purl.uniprot.org/uniprot/A0A2R9BPU7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/9597:PEX2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ARI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pex2/pex10/pex12 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9597:PSMB8 ^@ http://purl.uniprot.org/uniprot/A0A2R9CBN1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:HACD4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BPY9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:VASP ^@ http://purl.uniprot.org/uniprot/A0A2R9BN03 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Ena/VASP family.|||Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.|||cytoskeleton http://togogenome.org/gene/9597:PSMB6 ^@ http://purl.uniprot.org/uniprot/A0A2R9CGY9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:AMT ^@ http://purl.uniprot.org/uniprot/A0A2R9BRU1|||http://purl.uniprot.org/uniprot/A0A2R9BVB8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvT family.|||Mitochondrion|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/9597:CIAO2A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZR21|||http://purl.uniprot.org/uniprot/A0A2R8ZVQ9 ^@ Similarity ^@ Belongs to the MIP18 family. http://togogenome.org/gene/9597:PIK3C2A ^@ http://purl.uniprot.org/uniprot/A0A2R9BSX3 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9597:ACADS ^@ http://purl.uniprot.org/uniprot/A0A2R8ZI63 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9597:RPS26 ^@ http://purl.uniprot.org/uniprot/A0A2R9BFK5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS26 family. http://togogenome.org/gene/9597:B4GAT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BXA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 49 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:CXCL6 ^@ http://purl.uniprot.org/uniprot/A0A2R9BGM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9597:ITGB2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B178 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane|||Membrane raft http://togogenome.org/gene/9597:LRP10 ^@ http://purl.uniprot.org/uniprot/A0A2R9AA34 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:PPP2R2B ^@ http://purl.uniprot.org/uniprot/A0A2R9CFA8|||http://purl.uniprot.org/uniprot/A0A2R9CI09 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/9597:GTF2A1L ^@ http://purl.uniprot.org/uniprot/A0A2R8ZRW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 1 family.|||Nucleus http://togogenome.org/gene/9597:RBBP4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BXZ7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:ERGIC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABJ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/9597:ACTR5 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z991 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9597:SH3GL3 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z992|||http://purl.uniprot.org/uniprot/A0A2R8Z996 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Membrane http://togogenome.org/gene/9597:CSTF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJ77|||http://purl.uniprot.org/uniprot/A0A2R9AJ87 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:CLSTN3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AML8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calsyntenin family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Postsynaptic cell membrane http://togogenome.org/gene/9597:BBS5 ^@ http://purl.uniprot.org/uniprot/A0A2R9BW62|||http://purl.uniprot.org/uniprot/A0A2R9BWT6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BBS5 family.|||Membrane|||Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10.|||The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.|||centriolar satellite|||cilium membrane http://togogenome.org/gene/9597:BUD13 ^@ http://purl.uniprot.org/uniprot/A0A2R9C569 ^@ Similarity ^@ Belongs to the CWC26 family. http://togogenome.org/gene/9597:CNTNAP4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDR2 ^@ Caution|||Similarity ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:BET1L ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEA9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:RPS6KA6 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZB76|||http://purl.uniprot.org/uniprot/A0A2R8ZI06 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9597:MON1A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDN4|||http://purl.uniprot.org/uniprot/A0A2R8ZJV7 ^@ Function|||Similarity ^@ Belongs to the MON1/SAND family.|||Plays an important role in membrane trafficking through the secretory apparatus. http://togogenome.org/gene/9597:GABARAP ^@ http://purl.uniprot.org/uniprot/A0A2R9AE68 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9597:LOC100976343 ^@ http://purl.uniprot.org/uniprot/A0A2R9C308 ^@ Function|||Subcellular Location Annotation ^@ Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:BTK ^@ http://purl.uniprot.org/uniprot/A0A2R9BPC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cytoplasm http://togogenome.org/gene/9597:GAL ^@ http://purl.uniprot.org/uniprot/A0A2R9ADP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the galanin family.|||Secreted http://togogenome.org/gene/9597:NDUFB7 ^@ http://purl.uniprot.org/uniprot/A0A2R9CLC2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB7 subunit family.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/9597:VPS25 ^@ http://purl.uniprot.org/uniprot/A0A2R9B279 ^@ Similarity ^@ Belongs to the VPS25 family. http://togogenome.org/gene/9597:ESRRA ^@ http://purl.uniprot.org/uniprot/A0A2R9BL88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/9597:INSL5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZN15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/9597:PTPRG ^@ http://purl.uniprot.org/uniprot/A0A2R9BDA7|||http://purl.uniprot.org/uniprot/A0A2R9BLW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.|||Membrane http://togogenome.org/gene/9597:GABRE ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSJ9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9597:CEP19 ^@ http://purl.uniprot.org/uniprot/A0A2R9BMC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP19 family.|||centriole|||cilium basal body|||spindle pole http://togogenome.org/gene/9597:SMARCB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A3R9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNF5 family.|||Component of the multiprotein chromatin-remodeling complexes SWI/SNF.|||Nucleus http://togogenome.org/gene/9597:VPS52 ^@ http://purl.uniprot.org/uniprot/A0A2R9BVC3 ^@ Similarity ^@ Belongs to the VPS52 family. http://togogenome.org/gene/9597:TASP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C3Z2 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/9597:LOC100988840 ^@ http://purl.uniprot.org/uniprot/A0A2R9B807 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9597:ATP2B4 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7M1|||http://purl.uniprot.org/uniprot/A0A2R9CF82 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:HOOK2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hook family.|||cytoskeleton http://togogenome.org/gene/9597:EME1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CGG2 ^@ Similarity ^@ Belongs to the EME1/MMS4 family. http://togogenome.org/gene/9597:CXXC5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZN63 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:NEK9 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZH82 ^@ Similarity ^@ Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. http://togogenome.org/gene/9597:RUNX1T1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AHT1|||http://purl.uniprot.org/uniprot/A0A2R9APW9|||http://purl.uniprot.org/uniprot/A0A2R9APX5 ^@ Similarity ^@ Belongs to the CBFA2T family. http://togogenome.org/gene/9597:UBE2E2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AB22 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9597:GUCY1A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B7A6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Cytoplasm http://togogenome.org/gene/9597:RIC8A ^@ http://purl.uniprot.org/uniprot/A0A2R9C423 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the synembryn family.|||Cytoplasm|||Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.|||Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. http://togogenome.org/gene/9597:AIPL1 ^@ http://purl.uniprot.org/uniprot/Q95MN9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with NUB1.|||May be important in protein trafficking and/or protein folding and stabilization.|||Nucleus http://togogenome.org/gene/9597:PSMA4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZRW7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9597:PMCH ^@ http://purl.uniprot.org/uniprot/B5LWR6 ^@ Similarity ^@ Belongs to the melanin-concentrating hormone family. http://togogenome.org/gene/9597:RPL10A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCW8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL1 family. http://togogenome.org/gene/9597:LOC100994493 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z791 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP53 family.|||May play a role in ribosome biogenesis.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9597:LOC100986643 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPT0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9597:PEDS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A6Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase CarF family.|||Membrane http://togogenome.org/gene/9597:VRTN ^@ http://purl.uniprot.org/uniprot/A0A2R8ZG53 ^@ Similarity ^@ Belongs to the vertnin family. http://togogenome.org/gene/9597:RPS19 ^@ http://purl.uniprot.org/uniprot/A0A2R9C3Q8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS19 family. http://togogenome.org/gene/9597:ABHD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CQN6 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/9597:EFNA4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSX4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:IL6R ^@ http://purl.uniprot.org/uniprot/A0A2R9A372 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 3 subfamily.|||Membrane http://togogenome.org/gene/9597:AASS ^@ http://purl.uniprot.org/uniprot/A0A2R9CGH5 ^@ Similarity ^@ In the C-terminal section; belongs to the saccharopine dehydrogenase family.|||In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/9597:SLC7A11 ^@ http://purl.uniprot.org/uniprot/A0A2R9C3C2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:CLEC12A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZC44 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:LOC100976988 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPB9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:VPS11 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZI53 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS11 family.|||Cytoplasmic vesicle|||Early endosome|||Late endosome membrane|||Lysosome membrane|||Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.|||autophagosome|||clathrin-coated vesicle http://togogenome.org/gene/9597:BRMS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B3T4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:SRFBP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B8L8 ^@ Function|||Subunit ^@ Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4.|||May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells. http://togogenome.org/gene/9597:LOC100973863 ^@ http://purl.uniprot.org/uniprot/A0A2R9A6B4|||http://purl.uniprot.org/uniprot/A0A2R9A6C2|||http://purl.uniprot.org/uniprot/A0A2R9ABM0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neuregulin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Secreted http://togogenome.org/gene/9597:SIRT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B8Q6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the sirtuin family. Class I subfamily.|||Binds 1 zinc ion per subunit.|||NAD-dependent protein deacetylase. http://togogenome.org/gene/9597:OXSM ^@ http://purl.uniprot.org/uniprot/A0A2R9APM2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.|||Mitochondrion http://togogenome.org/gene/9597:CD82 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZRD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9597:SERPINA7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BCB8 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9597:RPL37 ^@ http://purl.uniprot.org/uniprot/A0A2R9AFB3 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/9597:TADA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CFK1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TADA1 family.|||Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.|||Nucleus|||Probably involved in transcriptional regulation. http://togogenome.org/gene/9597:LOC100983089 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZRU3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:ROM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B4T6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRPH2/ROM1 family.|||Membrane http://togogenome.org/gene/9597:RHOT1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZU1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial Rho GTPase family.|||Membrane|||Mitochondrial GTPase involved in mitochondrial trafficking.|||Mitochondrion outer membrane http://togogenome.org/gene/9597:SFMBT1 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z8J9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:GTF2E1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AIJ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIE alpha subunit family.|||Nucleus|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. http://togogenome.org/gene/9597:DDX43 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXQ3 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9597:LOC100971765 ^@ http://purl.uniprot.org/uniprot/A0A2R9ASP0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:SNX21 ^@ http://purl.uniprot.org/uniprot/A0A2R9A0Y2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome membrane|||Membrane http://togogenome.org/gene/9597:MCM2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Chromosome|||Nucleus http://togogenome.org/gene/9597:GALNT5 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4V9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:TBX5 ^@ http://purl.uniprot.org/uniprot/A0A2R9A5H2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9597:CFB ^@ http://purl.uniprot.org/uniprot/A0A2R9CIE9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9597:SLC35B3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BWX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/9597:VTI1B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZP56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/9597:HINT2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZB15 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/9597:BEX5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIF4 ^@ Similarity ^@ Belongs to the BEX family. http://togogenome.org/gene/9597:ZNF500 ^@ http://purl.uniprot.org/uniprot/A0A2R9B9G5 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9597:SCP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CE57|||http://purl.uniprot.org/uniprot/A0A2R9CP81 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. Thiolase family.|||Cytoplasm|||Interacts with PEX5; the interaction is essential for peroxisomal import.|||Mitochondrion http://togogenome.org/gene/9597:PTP4A3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUK7 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9597:TAGLN ^@ http://purl.uniprot.org/uniprot/A0A2R9CFE8 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/9597:INO80C ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHV8|||http://purl.uniprot.org/uniprot/A0A2R8ZKZ6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:LOC100972512 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLR5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||Mitochondrion|||The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/9597:ZC2HC1C ^@ http://purl.uniprot.org/uniprot/A0A2R9AN57 ^@ Similarity ^@ Belongs to the ZC2HC1 family. http://togogenome.org/gene/9597:ECHS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BD22 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9597:PRUNE1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AX72 ^@ Similarity ^@ Belongs to the PPase class C family. Prune subfamily. http://togogenome.org/gene/9597:ICOS ^@ http://purl.uniprot.org/uniprot/A0A2R9BIK8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.|||Homodimer; disulfide-linked.|||Membrane http://togogenome.org/gene/9597:CCNB2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSA0 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9597:ANXA6 ^@ http://purl.uniprot.org/uniprot/A0A2R9ALV5|||http://purl.uniprot.org/uniprot/A0A2R9AMH2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.|||Melanosome http://togogenome.org/gene/9597:NFYA ^@ http://purl.uniprot.org/uniprot/A0A2R9C7U1|||http://purl.uniprot.org/uniprot/A0A2R9CID0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NFYA/HAP2 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.|||Heterotrimer.|||Nucleus http://togogenome.org/gene/9597:EDN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Secreted http://togogenome.org/gene/9597:UCN3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEH6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Binds with high affinity to CRF receptors 2-alpha and 2-beta.|||Secreted|||Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. http://togogenome.org/gene/9597:SLC6A6 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9K0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:MBD4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJD0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with MLH1.|||Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.|||Nucleus http://togogenome.org/gene/9597:PDE10A ^@ http://purl.uniprot.org/uniprot/A0A2R9AYB4 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9597:RNF40 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZS60 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BRE1 family.|||Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.|||Nucleus http://togogenome.org/gene/9597:CAV3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7C2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||caveola http://togogenome.org/gene/9597:NPPA ^@ http://purl.uniprot.org/uniprot/A0A2R9BL40 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the natriuretic peptide family.|||Cell projection|||Homodimer; disulfide-linked antiparallel dimer.|||May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips.|||May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips.|||May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.|||May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips.|||Secreted http://togogenome.org/gene/9597:LOC100977661 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDU8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:CLU ^@ http://purl.uniprot.org/uniprot/A0A2R9AC29 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Antiparallel disulfide-linked heterodimer of an alpha chain and a beta chain. Self-associates and forms higher oligomers.|||Belongs to the clusterin family.|||Endoplasmic reticulum|||Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.|||Membrane|||Microsome|||Mitochondrion membrane|||Nucleus|||Secreted|||chromaffin granule|||cytosol|||perinuclear region http://togogenome.org/gene/9597:SLC16A4 ^@ http://purl.uniprot.org/uniprot/A0A2R9B6J2|||http://purl.uniprot.org/uniprot/A0A2R9B803|||http://purl.uniprot.org/uniprot/A0A2R9B808 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:RIBC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CGR9|||http://purl.uniprot.org/uniprot/A0A2R9CJG0 ^@ Similarity ^@ Belongs to the RIB43A family. http://togogenome.org/gene/9597:ZNF432 ^@ http://purl.uniprot.org/uniprot/A0A2R9B526 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:CYP2S1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AFV4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9597:GLRX ^@ http://purl.uniprot.org/uniprot/A0A2R9CS70 ^@ Function|||Similarity ^@ Belongs to the glutaredoxin family.|||Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. http://togogenome.org/gene/9597:GINS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BV29 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS1/PSF1 family.|||Chromosome|||Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex.|||Nucleus|||Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. http://togogenome.org/gene/9597:INPP5K ^@ http://purl.uniprot.org/uniprot/A0A2R9CCA5 ^@ Similarity ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family. http://togogenome.org/gene/9597:ALDH6A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AAJ7 ^@ Function|||Similarity ^@ Belongs to the aldehyde dehydrogenase family.|||Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA. http://togogenome.org/gene/9597:HIGD1A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSI2 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/9597:SETD7 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZT30 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.|||Chromosome|||Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.|||Nucleus http://togogenome.org/gene/9597:MTX2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CH73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metaxin family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9597:LOC100972317 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDW3 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:LYSET ^@ http://purl.uniprot.org/uniprot/A0A2R9B5M6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LYSET family.|||Membrane http://togogenome.org/gene/9597:ABITRAM ^@ http://purl.uniprot.org/uniprot/A0A2R9A253 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABITRAM family.|||growth cone|||lamellipodium http://togogenome.org/gene/9597:SCN3A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIK3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel (TC 1.A.1.10) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.|||Membrane http://togogenome.org/gene/9597:DOCK4 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4S8 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9597:SMPDL3A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKG5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acid sphingomyelinase family.|||Binds 2 Zn(2+) per subunit.|||Secreted http://togogenome.org/gene/9597:ALOX5 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5L7 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the lipoxygenase family.|||Binds 1 Fe cation per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:QTRT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABY7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family.|||Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.|||Cytoplasm|||Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.|||Mitochondrion outer membrane http://togogenome.org/gene/9597:PARP6 ^@ http://purl.uniprot.org/uniprot/A0A2R9CPY3 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9597:AQP9 ^@ http://purl.uniprot.org/uniprot/A0A2R9CLD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9597:EVX1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPS1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:ILVBL ^@ http://purl.uniprot.org/uniprot/A0A2R9AGX9 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/9597:STK4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Nucleus http://togogenome.org/gene/9597:GAD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B9E1 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9597:SLC7A8 ^@ http://purl.uniprot.org/uniprot/A0A2R9A4Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:ERAP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A7J6 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9597:ADGRG1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZWN6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Membrane raft|||Secreted http://togogenome.org/gene/9597:SAMM50 ^@ http://purl.uniprot.org/uniprot/A0A2R9A8J6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAM50/omp85 family.|||Mitochondrion outer membrane http://togogenome.org/gene/9597:XKR9 ^@ http://purl.uniprot.org/uniprot/A0A2R9B9M6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9597:SVEP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABC8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9597:IBSP ^@ http://purl.uniprot.org/uniprot/A0A2R9BPW7 ^@ Function|||Subcellular Location Annotation ^@ Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.|||Secreted http://togogenome.org/gene/9597:STK38 ^@ http://purl.uniprot.org/uniprot/A0A2R9BT32 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:RUVBL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BQN2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RuvB family.|||Dynein axonemal particle|||Nucleus|||Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. http://togogenome.org/gene/9597:NFKB2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACD8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9597:TMTC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/9597:FGF12 ^@ http://purl.uniprot.org/uniprot/A0A2R9BAP4 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9597:ZNF776 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSR4 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:UROS ^@ http://purl.uniprot.org/uniprot/A0A2R9A8M7 ^@ Similarity ^@ Belongs to the uroporphyrinogen-III synthase family. http://togogenome.org/gene/9597:PFKFB2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CAA0|||http://purl.uniprot.org/uniprot/A0A2R9CI35 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/9597:DIS3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C8K9|||http://purl.uniprot.org/uniprot/A0A2R9CB13 ^@ Similarity ^@ Belongs to the RNR ribonuclease family. http://togogenome.org/gene/9597:FABP2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZM56 ^@ Function|||Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor. http://togogenome.org/gene/9597:TM9SF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9P5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/9597:TMEM33 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z5N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PER33/POM33 family.|||Membrane http://togogenome.org/gene/9597:RPAIN ^@ http://purl.uniprot.org/uniprot/A0A2R9AGI4|||http://purl.uniprot.org/uniprot/A0A2R9AGJ0|||http://purl.uniprot.org/uniprot/A0A2R9ANB9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:B4GALT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BWS7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9597:UBIAD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CKG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family.|||Membrane http://togogenome.org/gene/9597:PIK3CG ^@ http://purl.uniprot.org/uniprot/A0A2R9CFV4 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9597:STX6 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Golgi apparatus membrane http://togogenome.org/gene/9597:PAPOLG ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJ86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the poly(A) polymerase family.|||Nucleus http://togogenome.org/gene/9597:ZNF263 ^@ http://purl.uniprot.org/uniprot/A0A2R9ATI4 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9597:LYRM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AIH7 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9597:VIP ^@ http://purl.uniprot.org/uniprot/A0A2R9AEX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/9597:IL13 ^@ http://purl.uniprot.org/uniprot/A0A2R9AD54|||http://purl.uniprot.org/uniprot/A0A2R9AD95 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-4/IL-13 family.|||Interacts with IL13RA2.|||Secreted http://togogenome.org/gene/9597:AS3MT ^@ http://purl.uniprot.org/uniprot/A0A2R9CA94 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Arsenite methyltransferase family. http://togogenome.org/gene/9597:CBL ^@ http://purl.uniprot.org/uniprot/A0A2R9BP66 ^@ Domain|||Function ^@ E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.|||The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain. http://togogenome.org/gene/9597:BST1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B8H2 ^@ Similarity ^@ Belongs to the ADP-ribosyl cyclase family. http://togogenome.org/gene/9597:NUPR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQR1 ^@ Similarity ^@ Belongs to the NUPR family. http://togogenome.org/gene/9597:UCMA ^@ http://purl.uniprot.org/uniprot/A0A2R9A5B0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UCMA family.|||May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.|||extracellular matrix http://togogenome.org/gene/9597:AGA ^@ http://purl.uniprot.org/uniprot/A0A2R9BM07 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/9597:NCBP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZS19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NCBP1 family.|||Nucleus http://togogenome.org/gene/9597:LOC100975235 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAW7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:KRT72 ^@ http://purl.uniprot.org/uniprot/A0A2R9CPA3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9597:CSNK1A1L ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLE3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:APOH ^@ http://purl.uniprot.org/uniprot/A0A2R9C3R2 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9597:PPP2R3C ^@ http://purl.uniprot.org/uniprot/A0A2R9AFJ5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:CACNA2D1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZS28 ^@ Similarity ^@ Belongs to the calcium channel subunit alpha-2/delta family. http://togogenome.org/gene/9597:LOC100994139 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABR9 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/9597:NOX5 ^@ http://purl.uniprot.org/uniprot/A0A2R9BPS1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:IARS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A7Y9 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9597:ATG101 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUP9 ^@ Similarity ^@ Belongs to the ATG101 family. http://togogenome.org/gene/9597:SPP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYD7|||http://purl.uniprot.org/uniprot/A0A2R9BYZ3|||http://purl.uniprot.org/uniprot/A0A2R9C8E8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the osteopontin family.|||Secreted http://togogenome.org/gene/9597:CRK ^@ http://purl.uniprot.org/uniprot/A0A2R9A9X4 ^@ Similarity ^@ Belongs to the CRK family. http://togogenome.org/gene/9597:GRK3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A3T4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9597:GLO1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BBA5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the glyoxalase I family.|||Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.|||Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. http://togogenome.org/gene/9597:GPRC5A ^@ http://purl.uniprot.org/uniprot/A0A2R9AIZ2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:GPN1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZRV0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II.|||Cytoplasm|||Nucleus|||Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/9597:ADH1B ^@ http://purl.uniprot.org/uniprot/A0A2R9BG66 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/9597:PDGFB ^@ http://purl.uniprot.org/uniprot/A0A2R9ACQ2 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/9597:B4GALT3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AR93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9597:LOC100995923 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TOR1AIP family.|||Membrane http://togogenome.org/gene/9597:GFM2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BBQ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.|||Mitochondrion http://togogenome.org/gene/9597:PHB1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZR25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Cell membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9597:SEMA3F ^@ http://purl.uniprot.org/uniprot/A0A2R9CH72|||http://purl.uniprot.org/uniprot/A0A2R9CH76 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:LOC100993304 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFL1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:ZNF655 ^@ http://purl.uniprot.org/uniprot/A0A2R9CHV3 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:RNF7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BAE1 ^@ Similarity ^@ Belongs to the RING-box family. http://togogenome.org/gene/9597:ADGRL4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CMJ5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:TGFBI ^@ http://purl.uniprot.org/uniprot/A0A2R9B390 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9597:DNASE2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXV7 ^@ Similarity ^@ Belongs to the DNase II family. http://togogenome.org/gene/9597:PGS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AEN2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-II family.|||Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.|||Mitochondrion http://togogenome.org/gene/9597:AP1G2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AE73 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/9597:MLST8 ^@ http://purl.uniprot.org/uniprot/A0A2R9ASY7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat LST8 family.|||Cytoplasm|||Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB. Interacts with MEAK7. Interacts with SIK3.|||Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1. mTORC2 also modulates the phosphorylation of PRKCA. http://togogenome.org/gene/9597:REV3L ^@ http://purl.uniprot.org/uniprot/A0A2R9B4X2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B family.|||Nucleus http://togogenome.org/gene/9597:TECRL ^@ http://purl.uniprot.org/uniprot/A0A2R9BR07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Membrane http://togogenome.org/gene/9597:MTOR ^@ http://purl.uniprot.org/uniprot/A0A2R9BI87 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. http://togogenome.org/gene/9597:HBA2 ^@ http://purl.uniprot.org/uniprot/P69906 ^@ Function|||Miscellaneous|||Similarity|||Subunit|||Tissue Specificity ^@ Belongs to the globin family.|||Gives blood its red color.|||Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1. Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.|||Heterotetramer of two alpha chains and two beta chains in adult hemoglobin A (HbA); two alpha chains and two delta chains in adult hemoglobin A2 (HbA2); two alpha chains and two epsilon chains in early embryonic hemoglobin Gower-2; two alpha chains and two gamma chains in fetal hemoglobin F (HbF).|||Involved in oxygen transport from the lung to the various peripheral tissues.|||Red blood cells. http://togogenome.org/gene/9597:METTL8 ^@ http://purl.uniprot.org/uniprot/A0A2R9AB17 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/9597:SCAMP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A3R5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/9597:MTMR9 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTD2 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9597:RSRP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACL1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RSRP family.|||Nucleus|||Probably acts as a spliceosomal factor that contributes to spliceosome assembly and regulates the isoform switching of proteins such as PARP6. http://togogenome.org/gene/9597:PTPN21 ^@ http://purl.uniprot.org/uniprot/A0A2R9B463 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||cytoskeleton http://togogenome.org/gene/9597:IGFBP5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQV0 ^@ Caution|||Function|||Subcellular Location Annotation ^@ IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9597:B4GALT7 ^@ http://purl.uniprot.org/uniprot/A0A2R9CIW6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9597:INTS12 ^@ http://purl.uniprot.org/uniprot/A0A2R9C2D4 ^@ Similarity|||Subunit ^@ Belongs to the Integrator subunit 12 family.|||Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12. http://togogenome.org/gene/9597:DUSP13B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDD0 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/9597:TH ^@ http://purl.uniprot.org/uniprot/A0A2R9BE28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.|||axon|||perinuclear region|||synaptic vesicle http://togogenome.org/gene/9597:PHGDH ^@ http://purl.uniprot.org/uniprot/A0A2R9C2H1 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/9597:TNFSF8 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJ75 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9597:GHRH ^@ http://purl.uniprot.org/uniprot/A0A2R9B5V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/9597:CDX2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQ68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Caudal homeobox family.|||Nucleus http://togogenome.org/gene/9597:ADSS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B5Q0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Mitochondrion|||Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.|||Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. http://togogenome.org/gene/9597:EIF2B5 ^@ http://purl.uniprot.org/uniprot/A0A2R9AD93 ^@ Similarity ^@ Belongs to the eIF-2B gamma/epsilon subunits family. http://togogenome.org/gene/9597:CDR2L ^@ http://purl.uniprot.org/uniprot/A0A2R9C5B2 ^@ Similarity ^@ Belongs to the CDR2 family. http://togogenome.org/gene/9597:ATG9A ^@ http://purl.uniprot.org/uniprot/A0A2R9BA63 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.|||Preautophagosomal structure membrane http://togogenome.org/gene/9597:TMEM230 ^@ http://purl.uniprot.org/uniprot/A0A2R9AAV7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM134/TMEM230 family.|||Early endosome|||Endosome|||Involved in trafficking and recycling of synaptic vesicles.|||Late endosome|||Membrane|||Recycling endosome|||autophagosome|||synaptic vesicle|||trans-Golgi network http://togogenome.org/gene/9597:AGXT ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTW4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||Peroxisome http://togogenome.org/gene/9597:VCP ^@ http://purl.uniprot.org/uniprot/A0A2R9C1U9 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9597:EXOG ^@ http://purl.uniprot.org/uniprot/A0A2R9AWM6 ^@ Similarity ^@ Belongs to the DNA/RNA non-specific endonuclease family. http://togogenome.org/gene/9597:NTHL1 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7L4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nth/MutY family.|||Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.|||Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.|||Interacts with YBX1.|||Mitochondrion|||Nucleus http://togogenome.org/gene/9597:SLC6A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CH47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9597:PARP8 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9J6|||http://purl.uniprot.org/uniprot/A0A2R9AF07 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9597:QPCT ^@ http://purl.uniprot.org/uniprot/A0A2R9AL20 ^@ Similarity ^@ Belongs to the glutaminyl-peptide cyclotransferase family. http://togogenome.org/gene/9597:UBP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZJ8|||http://purl.uniprot.org/uniprot/A0A2R9A0P3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus http://togogenome.org/gene/9597:CPA6 ^@ http://purl.uniprot.org/uniprot/A0A2R9BZG7 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9597:UST ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 3 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:DCAF1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPRBP/DCAF1 family.|||Nucleus http://togogenome.org/gene/9597:DMGDH ^@ http://purl.uniprot.org/uniprot/A0A2R8ZK34 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/9597:HMOX2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZ65 ^@ Similarity ^@ Belongs to the heme oxygenase family. http://togogenome.org/gene/9597:HESX1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZ78|||http://purl.uniprot.org/uniprot/A1YGA2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ANF homeobox family.|||Can form heterodimers with PROP1 in binding to DNA. Interacts with TLE1 (By similarity).|||Nucleus|||Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity). http://togogenome.org/gene/9597:EFHC1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBJ6|||http://purl.uniprot.org/uniprot/A0A2R8ZBM0 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9597:VWCE ^@ http://purl.uniprot.org/uniprot/A0A2R9B0G7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:STARD6 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABZ8 ^@ Function ^@ May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols. http://togogenome.org/gene/9597:RTN4IP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AN49 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/9597:LCE3A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEP1 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9597:MEA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CF16 ^@ Function ^@ May play an important role in spermatogenesis and/or testis development. http://togogenome.org/gene/9597:MANBA ^@ http://purl.uniprot.org/uniprot/A0A2R9A4B3|||http://purl.uniprot.org/uniprot/A0A2R9A5H7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 2 family.|||Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.|||Lysosome|||Monomer. http://togogenome.org/gene/9597:C9H9orf131 ^@ http://purl.uniprot.org/uniprot/A0A2R9BGE3 ^@ Similarity ^@ Belongs to the SPATA31 family. http://togogenome.org/gene/9597:ATP6V0D1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BWI2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9597:CDK5RAP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEK1 ^@ Similarity ^@ Belongs to the methylthiotransferase family. MiaB subfamily. http://togogenome.org/gene/9597:PIWIL2 ^@ http://purl.uniprot.org/uniprot/W0HFS1 ^@ Similarity ^@ Belongs to the argonaute family. http://togogenome.org/gene/9597:IL17B ^@ http://purl.uniprot.org/uniprot/A0A2R9AYH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/9597:SCFD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CCU5 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9597:IRF8 ^@ http://purl.uniprot.org/uniprot/A0A2R9B2H7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:CAPRIN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C6B2|||http://purl.uniprot.org/uniprot/A0A2R9C8Q1 ^@ Similarity ^@ Belongs to the caprin family. http://togogenome.org/gene/9597:DDR2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ADM8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:MYD88 ^@ http://purl.uniprot.org/uniprot/B3Y679 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses, induces IL1B release through NLRP3 inflammasome activation (By similarity). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity).|||Cytoplasm|||Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their respective TIR domains. Interacts with IL18R1. Interacts with BMX, IL1RL1, IKBKE and IRF7. Interacts with LRRFIP1 and LRRFIP2; this interaction positively regulates Toll-like receptor (TLR) signaling in response to agonist. Interacts with FLII. LRRFIP1 and LRRFIP2 compete with FLII for MYD88-binding. Interacts with IRF1. Upon IL1B treatment, forms a complex with PELI1, IRAK1, IRAK4 and TRAF6; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression. May interact with PIK3AP1. Interacts (via TIR domain) with DHX9 (via H2A and OB-fold regions); this interaction is direct. Interacts with OTUD4 deubiquitinase; the interaction is direct.|||Nucleus|||The intermediate domain (ID) is required for the phosphorylation and activation of IRAK.|||Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination. OTUD4 specifically hydrolyzes 'Lys-63'-linked polyubiquitinated MYD88. http://togogenome.org/gene/9597:SH3BP5L ^@ http://purl.uniprot.org/uniprot/A0A2R9APA4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SH3BP5 family.|||Cytoplasm|||Functions as guanine nucleotide exchange factor (GEF) for RAB11A.|||Interacts with GDP-bound and nucleotide-free forms of RAB11A.|||The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape. http://togogenome.org/gene/9597:FUT7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BCR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9597:DGAT2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFN0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:LPL ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTC4 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Cell membrane|||Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.|||Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted|||Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.|||extracellular matrix http://togogenome.org/gene/9597:TRPM7 ^@ http://purl.uniprot.org/uniprot/A0A2R9B3G2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.|||Membrane http://togogenome.org/gene/9597:ADORA3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B2Z6|||http://purl.uniprot.org/uniprot/A0A2R9B9K4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. http://togogenome.org/gene/9597:ADAMTS6 ^@ http://purl.uniprot.org/uniprot/A0A2R9B0X2 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9597:KCNAB2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shaker potassium channel beta subunit family.|||Cell membrane|||Membrane|||axon|||cytoskeleton|||synaptosome http://togogenome.org/gene/9597:LOC100987236 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJZ7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. Interacts with RNPS1. Interacts with the SRP receptor subunit SRPRA.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development.|||Cytoplasm|||Endoplasmic reticulum|||Nucleus speckle|||The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.|||The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER. http://togogenome.org/gene/9597:MYORG ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJA4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/9597:NF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AF69|||http://purl.uniprot.org/uniprot/A0A2R9ALW4 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/9597:NMBR ^@ http://purl.uniprot.org/uniprot/A0A2R9CMF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:PLSCR5 ^@ http://purl.uniprot.org/uniprot/A0A2R9B5H2 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/9597:ATAD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CHR1 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9597:H1-1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJ78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9597:RBM8A ^@ http://purl.uniprot.org/uniprot/A0A2R9A8V1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RBM8A family.|||Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.|||Cytoplasm|||Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.|||Nucleus|||Nucleus speckle http://togogenome.org/gene/9597:SLC2A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AVB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Cell membrane|||Membrane|||Photoreceptor inner segment http://togogenome.org/gene/9597:IL3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B411 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-3 family.|||Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB. Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program. Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK.|||Secreted http://togogenome.org/gene/9597:PPCS ^@ http://purl.uniprot.org/uniprot/A0A2R9C4I9 ^@ Similarity ^@ Belongs to the PPC synthetase family. http://togogenome.org/gene/9597:KHDC4 ^@ http://purl.uniprot.org/uniprot/A0A2R9A3L3 ^@ Similarity ^@ Belongs to the KHDC4 family. http://togogenome.org/gene/9597:ICAM2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B837 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. ICAM family.|||Membrane http://togogenome.org/gene/9597:CBS ^@ http://purl.uniprot.org/uniprot/A0A2R9CEY1 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/9597:LOC106634091 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPL7 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9597:CAMK2A ^@ http://purl.uniprot.org/uniprot/A0A2R9CAY6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9597:DCN ^@ http://purl.uniprot.org/uniprot/A0A2R9BU23 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.|||May affect the rate of fibrils formation.|||extracellular matrix http://togogenome.org/gene/9597:GDF3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B2U4 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9597:SMG8 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1Q9 ^@ Function|||Similarity ^@ Belongs to the SMG8 family.|||Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. http://togogenome.org/gene/9597:NUDT6 ^@ http://purl.uniprot.org/uniprot/A0A2R9C965 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family.|||Cytoplasm|||May contribute to the regulation of cell proliferation.|||Mitochondrion|||Monomer and homodimer.|||Nucleus http://togogenome.org/gene/9597:CNOT7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BER6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/9597:EPHB6 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQ56 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:GBA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CAF1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the non-lysosomal glucosylceramidase family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. http://togogenome.org/gene/9597:EXOSC8 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZU31 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:PHACTR2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C152|||http://purl.uniprot.org/uniprot/A0A2R9C3N9 ^@ Similarity|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin. http://togogenome.org/gene/9597:BRINP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CIU2 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/9597:SUV39H1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AA50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.|||Nucleus|||centromere http://togogenome.org/gene/9597:RIPPLY1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BR24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ripply family.|||Nucleus http://togogenome.org/gene/9597:LOC100987487 ^@ http://purl.uniprot.org/uniprot/A0A2R9BCR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTF2H2 family.|||Nucleus http://togogenome.org/gene/9597:ACTR2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACM5|||http://purl.uniprot.org/uniprot/A0A2R9AHM0 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9597:ZNF267 ^@ http://purl.uniprot.org/uniprot/A0A2R9B2J0|||http://purl.uniprot.org/uniprot/A0A2R9B2J4 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:EVA1C ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFC7 ^@ Similarity ^@ Belongs to the EVA1 family. http://togogenome.org/gene/9597:PHAF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BNC5 ^@ Similarity ^@ Belongs to the PHAF1 family. http://togogenome.org/gene/9597:PPT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C1E5 ^@ Similarity ^@ Belongs to the palmitoyl-protein thioesterase family. http://togogenome.org/gene/9597:ATP6V1G3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B0Y6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9597:SDHB ^@ http://purl.uniprot.org/uniprot/A0A2R9BCD0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster.|||Binds 1 [3Fe-4S] cluster.|||Binds 1 [4Fe-4S] cluster.|||Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/9597:LOC100973697 ^@ http://purl.uniprot.org/uniprot/A0A2R9C8K5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS10 family. http://togogenome.org/gene/9597:PPIB ^@ http://purl.uniprot.org/uniprot/A0A2R9AT23 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9597:ERGIC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ADL5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/9597:CBLIF ^@ http://purl.uniprot.org/uniprot/A0A2R9BIS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic cobalamin transport proteins family.|||Secreted http://togogenome.org/gene/9597:BNIP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AD20 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:DPEP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BIS0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.|||Homodimer; disulfide-linked.|||Membrane http://togogenome.org/gene/9597:EXT1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:UTP3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAS10 family.|||nucleolus http://togogenome.org/gene/9597:TXLNA ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7Q5 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/9597:COPG1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYG8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPG family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/9597:ADGRG6 ^@ http://purl.uniprot.org/uniprot/A0A2R9AAU3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:CCDC124 ^@ http://purl.uniprot.org/uniprot/A0A2R9AG76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC124 family.|||Midbody http://togogenome.org/gene/9597:LRP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A7D0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LDLR family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:THBD ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHT7 ^@ Caution|||Function|||Subunit ^@ Interacts with ITGAL, ITGAM and ITGB2.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. http://togogenome.org/gene/9597:SPSB4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AD32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPSB family.|||Cytoplasm http://togogenome.org/gene/9597:HNMT ^@ http://purl.uniprot.org/uniprot/A0A2R9A9L0 ^@ Function|||Subunit ^@ Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.|||Monomer. http://togogenome.org/gene/9597:DPAGT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C1T0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family.|||Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:CAPN11 ^@ http://purl.uniprot.org/uniprot/A0A2R9BB88 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9597:ZNF622 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the REI1 family.|||Cytoplasm http://togogenome.org/gene/9597:CD93 ^@ http://purl.uniprot.org/uniprot/A0A2R9BXT9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:GSTO1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A5C4 ^@ Function|||Similarity ^@ Belongs to the GST superfamily. Omega family.|||Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). http://togogenome.org/gene/9597:YJU2B ^@ http://purl.uniprot.org/uniprot/A0A2R9A3W3 ^@ Similarity ^@ Belongs to the CWC16 family. http://togogenome.org/gene/9597:KIF17 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQV2 ^@ Caution|||Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:LOC100969266 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZP05 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:ASB4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CA43 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9597:WIF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AG94 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9597:POU4F3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/9597:CCND2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BB92 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9597:LOC100979321 ^@ http://purl.uniprot.org/uniprot/A0A2R9AA81 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. http://togogenome.org/gene/9597:MMP28 ^@ http://purl.uniprot.org/uniprot/A0A2R9A4I7 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9597:LOC100978807 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTJ7 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9597:NFE2L1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AIZ4|||http://purl.uniprot.org/uniprot/A0A2R9ANQ5|||http://purl.uniprot.org/uniprot/A0A2R9ANQ6 ^@ Similarity ^@ Belongs to the bZIP family. CNC subfamily. http://togogenome.org/gene/9597:TNMD ^@ http://purl.uniprot.org/uniprot/A0A2R9B8B7 ^@ Similarity ^@ Belongs to the chondromodulin-1 family. http://togogenome.org/gene/9597:YPEL4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AMH0 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9597:SCD ^@ http://purl.uniprot.org/uniprot/A0A2R9AD04 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Membrane|||The histidine box domains are involved in binding the catalytic metal ions. http://togogenome.org/gene/9597:HLCS ^@ http://purl.uniprot.org/uniprot/A0A2R9AVQ2 ^@ Similarity ^@ Belongs to the biotin--protein ligase family. http://togogenome.org/gene/9597:SLC10A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AN81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/9597:SIAH1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJ65 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/9597:IL23A ^@ http://purl.uniprot.org/uniprot/A0A2R9CIV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-6 superfamily.|||Secreted http://togogenome.org/gene/9597:ADIPOR2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B284 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9597:ZNF613 ^@ http://purl.uniprot.org/uniprot/A0A2R9BLW3 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:TET3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AHE4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TET family.|||Binds 1 Fe(2+) ion per subunit.|||Chromosome|||Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.|||The zinc ions have a structural role. http://togogenome.org/gene/9597:ITIH2 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z603 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/9597:OGDHL ^@ http://purl.uniprot.org/uniprot/A0A2R9B524 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/9597:CRYBG1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AHZ4 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9597:CCL14 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9597:SCML4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCM family.|||Nucleus http://togogenome.org/gene/9597:EARS2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZ88 ^@ Function|||Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). http://togogenome.org/gene/9597:PNKD ^@ http://purl.uniprot.org/uniprot/A0A2R9B600|||http://purl.uniprot.org/uniprot/A0A2R9B8M0 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. http://togogenome.org/gene/9597:RIPOR2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CLI6|||http://purl.uniprot.org/uniprot/A0A2R9CLL9 ^@ Similarity ^@ Belongs to the RIPOR family. http://togogenome.org/gene/9597:ECI1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BNM9 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9597:LOC100973279 ^@ http://purl.uniprot.org/uniprot/A0A2R9CF96 ^@ Similarity ^@ Belongs to the MIX23 family. http://togogenome.org/gene/9597:LOC100977832 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZK39 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DIPP subfamily. http://togogenome.org/gene/9597:ATP10B ^@ http://purl.uniprot.org/uniprot/A0A2R9C7A7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9597:SNRPE ^@ http://purl.uniprot.org/uniprot/A0A2R9C3U6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing.|||cytosol http://togogenome.org/gene/9597:HTR5A ^@ http://purl.uniprot.org/uniprot/A0A2R9BZG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:VPS4B ^@ http://purl.uniprot.org/uniprot/A0A2R9B0V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9597:LIN7C ^@ http://purl.uniprot.org/uniprot/A0A2R9B2V7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the lin-7 family.|||Cell membrane|||Lateral cell membrane|||Membrane|||Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.|||Postsynaptic density membrane|||tight junction http://togogenome.org/gene/9597:SLAIN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C8M5|||http://purl.uniprot.org/uniprot/A0A2R9C8X7 ^@ Similarity ^@ Belongs to the SLAIN motif-containing family. http://togogenome.org/gene/9597:SNRPF ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7G0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/9597:ARL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B1F7 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9597:KIF22 ^@ http://purl.uniprot.org/uniprot/A0A2R9ARP3 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9597:TMED4 ^@ http://purl.uniprot.org/uniprot/A0A2R9B5E4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:RPL35 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZRY3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/9597:ITGB3BP ^@ http://purl.uniprot.org/uniprot/A0A2R9AU50 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Transcription coregulator that can have both coactivator and corepressor functions.|||centromere|||kinetochore http://togogenome.org/gene/9597:ZNF337 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUC8 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:UBXN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BG52|||http://purl.uniprot.org/uniprot/A0A2R9BKR6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:PAPOLA ^@ http://purl.uniprot.org/uniprot/A0A2R9AJ48 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the poly(A) polymerase family.|||Binds 2 magnesium ions. Also active with manganese.|||Nucleus|||Polymerase that creates the 3'-poly(A) tail of mRNA's. http://togogenome.org/gene/9597:CLIC5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZN78 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/9597:PRCP ^@ http://purl.uniprot.org/uniprot/A0A2R9BCQ3 ^@ Similarity ^@ Belongs to the peptidase S28 family. http://togogenome.org/gene/9597:PPIF ^@ http://purl.uniprot.org/uniprot/A0A2R9ARV0 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9597:B2M ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-2-microglobulin family.|||Secreted http://togogenome.org/gene/9597:KIF21B ^@ http://purl.uniprot.org/uniprot/A0A2R9C367|||http://purl.uniprot.org/uniprot/A0A2R9C5Q4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9597:UNC5CL ^@ http://purl.uniprot.org/uniprot/A0A2R9CF24 ^@ Similarity ^@ Belongs to the unc-5 family. http://togogenome.org/gene/9597:SEMA3D ^@ http://purl.uniprot.org/uniprot/A0A2R9BIA1 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:SLC25A42 ^@ http://purl.uniprot.org/uniprot/A0A2R9BC62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9597:LOC103782669 ^@ http://purl.uniprot.org/uniprot/A0A2R9BPX7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9597:HENMT1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZWD2 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. HEN1 family. http://togogenome.org/gene/9597:PNMT ^@ http://purl.uniprot.org/uniprot/A0A2R9ARD0 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. http://togogenome.org/gene/9597:LOC103784470 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACR5 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:ELL3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Nucleus http://togogenome.org/gene/9597:SQLE ^@ http://purl.uniprot.org/uniprot/A0A2R9CMG7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the squalene monooxygenase family.|||Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9597:NDUFB3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C357 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB3 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:PTPA ^@ http://purl.uniprot.org/uniprot/A0A2R9CCS9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTPA-type PPIase family.|||Cytoplasm|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9597:PMVK ^@ http://purl.uniprot.org/uniprot/A0A2R9C6W1 ^@ Subcellular Location Annotation ^@ cytosol http://togogenome.org/gene/9597:NEDD8 ^@ http://purl.uniprot.org/uniprot/A0A2R9BN41 ^@ Similarity ^@ Belongs to the ubiquitin family. http://togogenome.org/gene/9597:LOC100986734 ^@ http://purl.uniprot.org/uniprot/A0A2R9AKZ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:OPHN1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJP9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Postsynapse|||Presynapse|||dendrite http://togogenome.org/gene/9597:PIGS ^@ http://purl.uniprot.org/uniprot/A0A2R9CGJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGS family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:SPA17 ^@ http://purl.uniprot.org/uniprot/A0A2R9BDD1 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates. http://togogenome.org/gene/9597:BEX1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZS10 ^@ Similarity ^@ Belongs to the BEX family. http://togogenome.org/gene/9597:TSPAN15 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4B2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9597:TBL1XR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CPA2 ^@ Similarity ^@ Belongs to the WD repeat EBI family. http://togogenome.org/gene/9597:FAM161B ^@ http://purl.uniprot.org/uniprot/A0A2R9BC30 ^@ Similarity ^@ Belongs to the FAM161 family. http://togogenome.org/gene/9597:CCL23 ^@ http://purl.uniprot.org/uniprot/A0A2R9ANS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9597:PCYT1A ^@ http://purl.uniprot.org/uniprot/A0A2R9AU96 ^@ Function|||Similarity ^@ Belongs to the cytidylyltransferase family.|||Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. http://togogenome.org/gene/9597:FABP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B589 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.|||Cytoplasm|||Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. http://togogenome.org/gene/9597:LOC103784296 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z736 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9597:SLC25A27 ^@ http://purl.uniprot.org/uniprot/A0A2R9A993 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9597:ATRAID ^@ http://purl.uniprot.org/uniprot/A0A2R9BB35 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:MAF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BII4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MAF1 family.|||Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.|||Nucleus http://togogenome.org/gene/9597:OVOL3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A5T5|||http://purl.uniprot.org/uniprot/A0A2R9AAK0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:VIL1 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z8Z4 ^@ Similarity ^@ Belongs to the villin/gelsolin family. http://togogenome.org/gene/9597:EXOC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CKU7|||http://purl.uniprot.org/uniprot/A0A2R9CN68 ^@ Similarity ^@ Belongs to the SEC3 family. http://togogenome.org/gene/9597:ADCK5 ^@ http://purl.uniprot.org/uniprot/A0A2R9C0F7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family. http://togogenome.org/gene/9597:PNCK ^@ http://purl.uniprot.org/uniprot/A0A2R9AEK0|||http://purl.uniprot.org/uniprot/A0A2R9AJZ2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:OSBPL8 ^@ http://purl.uniprot.org/uniprot/A0A2R9CL40 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9597:ZNF74 ^@ http://purl.uniprot.org/uniprot/A0A2R9B443 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:NPL ^@ http://purl.uniprot.org/uniprot/A0A2R9CI64 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family. NanA subfamily.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/9597:TAS2R60 ^@ http://purl.uniprot.org/uniprot/Q646D0 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane|||Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.|||Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). http://togogenome.org/gene/9597:TPM1 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z928|||http://purl.uniprot.org/uniprot/A0A2R8Z970|||http://purl.uniprot.org/uniprot/A0A2R8ZDB4|||http://purl.uniprot.org/uniprot/A0A2R8ZFR5|||http://purl.uniprot.org/uniprot/A0A2R8ZFU2|||http://purl.uniprot.org/uniprot/A0A2R8ZFZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9597:ZER1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B106 ^@ Similarity ^@ Belongs to the zyg-11 family. http://togogenome.org/gene/9597:LOC100973895 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFI4 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:KDM5C ^@ http://purl.uniprot.org/uniprot/A0A2R9BE67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JARID1 histone demethylase family.|||Nucleus http://togogenome.org/gene/9597:COQ3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCE2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Mitochondrion inner membrane|||O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. http://togogenome.org/gene/9597:DISP3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUF0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:DPYSL3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B4M2|||http://purl.uniprot.org/uniprot/A0A2R9B653 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/9597:PSMB10 ^@ http://purl.uniprot.org/uniprot/A0A2R9AV10 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:SEPTIN5 ^@ http://purl.uniprot.org/uniprot/A0A2R9CCR4|||http://purl.uniprot.org/uniprot/A0A2R9CN69 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9597:NXPE3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B367 ^@ Similarity ^@ Belongs to the NXPE family. http://togogenome.org/gene/9597:HDC ^@ http://purl.uniprot.org/uniprot/A0A2R9BKH8 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9597:DNAJC16 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYW5 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Plays an important role in regulating the size of autophagosomes during the formation process. http://togogenome.org/gene/9597:CNPY2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AFI8 ^@ Similarity ^@ Belongs to the canopy family. http://togogenome.org/gene/9597:TUBB4A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJQ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9597:ST8SIA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9597:SLC19A1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVI2|||http://purl.uniprot.org/uniprot/A0A2R8ZWP5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Basolateral cell membrane|||Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.|||Cell membrane|||Transporter that mediates the import of reduced folates. http://togogenome.org/gene/9597:LOC100968043 ^@ http://purl.uniprot.org/uniprot/A0A2R9APT6 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9597:KRT8 ^@ http://purl.uniprot.org/uniprot/A0A2R9A6T6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9597:CFAP300 ^@ http://purl.uniprot.org/uniprot/A0A2R9BP32 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP300 family.|||Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.|||Cytoplasm http://togogenome.org/gene/9597:AQP4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9597:EYA3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BMJ0 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/9597:NIPA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AFM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9597:CTSD ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Lysosome|||extracellular space http://togogenome.org/gene/9597:DNM3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJZ9|||http://purl.uniprot.org/uniprot/A0A2R9ALU9 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/9597:TMEM106A ^@ http://purl.uniprot.org/uniprot/A0A2R9B7T8 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/9597:TSHZ1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AAC2 ^@ Similarity ^@ Belongs to the teashirt C2H2-type zinc-finger protein family. http://togogenome.org/gene/9597:LOC100972703 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5Z0 ^@ Function|||Similarity ^@ Belongs to the cytochrome c oxidase subunit 6B.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. http://togogenome.org/gene/9597:DPEP3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AT60 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:ETV7 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLH3|||http://purl.uniprot.org/uniprot/A0A2R8ZPP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9597:RPLP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTM9 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/9597:WNT8A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAZ9|||http://purl.uniprot.org/uniprot/A0A2R8ZBG9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9597:MYOZ2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BB68 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/9597:EHD4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CKA0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/9597:SV2B ^@ http://purl.uniprot.org/uniprot/A0A2R9A589 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/9597:PTK7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BXV6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:ORMDL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AYK3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/9597:DLX4 ^@ http://purl.uniprot.org/uniprot/A0A2R9C8V4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:STMN4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CHU2|||http://purl.uniprot.org/uniprot/A0A2R9CHX5 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/9597:LOC100981854 ^@ http://purl.uniprot.org/uniprot/A0A2R9BBV2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bZIP family.|||Homodimer; binds DNA as homodimer. Heterodimer; heterodimerizes with other members of ATF family and with JUN family members.|||Nucleus|||Stress-responsive chromatin regulator that plays a role in various biological processes including innate immunological memory, adipocyte differentiation or telomerase regulation. In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di-methyltransferases thus silencing the transcription of target genes such as STAT1 in adipocytes, or genes involved in innate immunity in macrophages and adipocytes. Stress induces ATF7 phosphorylation that disrupts interactions with histone methyltransferase and enhances the association with coactivators containing histone acetyltransferase and/or histone demethylase, leading to disruption of the heterochromatin-like structure and subsequently transcriptional activation. In response to TNF-alpha, which is induced by various stresses, phosphorylated ATF7 and telomerase are released from telomeres leading to telomere shortening. http://togogenome.org/gene/9597:PARD6A ^@ http://purl.uniprot.org/uniprot/A0A2R9BT09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAR6 family.|||Cytoplasm|||tight junction http://togogenome.org/gene/9597:STYXL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ADM9 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9597:RPF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B9K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RPF2 family.|||nucleolus http://togogenome.org/gene/9597:ATP5PD ^@ http://purl.uniprot.org/uniprot/A0A2R9BBD8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase d subunit family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:NRN1L ^@ http://purl.uniprot.org/uniprot/A0A2R9B2T4 ^@ Similarity ^@ Belongs to the neuritin family. http://togogenome.org/gene/9597:SLC25A31 ^@ http://purl.uniprot.org/uniprot/A0A2R9A6Y1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/9597:NUTM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A006 ^@ Similarity ^@ Belongs to the NUT family. http://togogenome.org/gene/9597:CAV2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CAM3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||caveola http://togogenome.org/gene/9597:NKAP ^@ http://purl.uniprot.org/uniprot/A0A2R9AHB2 ^@ Similarity ^@ Belongs to the NKAP family. http://togogenome.org/gene/9597:TMEM161A ^@ http://purl.uniprot.org/uniprot/A0A2R9CJT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM161 family.|||Membrane http://togogenome.org/gene/9597:TECR ^@ http://purl.uniprot.org/uniprot/A0A2R9AIJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:SF3B5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDC0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SF3B5 family.|||Component of the spliceosome B complex.|||Nucleus http://togogenome.org/gene/9597:ADHFE1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CL72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.|||Mitochondrion http://togogenome.org/gene/9597:CRHR2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Membrane http://togogenome.org/gene/9597:VARS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CFL7 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9597:ACER1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7X1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Membrane http://togogenome.org/gene/9597:NPM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C8S0|||http://purl.uniprot.org/uniprot/A0A2R9C8S7 ^@ Similarity ^@ Belongs to the nucleoplasmin family. http://togogenome.org/gene/9597:DPP4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CCY4 ^@ Subcellular Location Annotation ^@ Cell membrane|||invadopodium membrane|||lamellipodium membrane http://togogenome.org/gene/9597:AWAT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BQE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9597:MED8 ^@ http://purl.uniprot.org/uniprot/A0A2R9B3A2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 8 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9597:CMAH ^@ http://purl.uniprot.org/uniprot/A0A2R9B733 ^@ Function|||Similarity ^@ Belongs to the CMP-Neu5Ac hydroxylase family.|||Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells. http://togogenome.org/gene/9597:TM2D2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AYD5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:RPS27 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9M6 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9597:ZNF471 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6X5 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:RAD21L1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad21 family.|||Nucleus http://togogenome.org/gene/9597:NDUFB5 ^@ http://purl.uniprot.org/uniprot/A0A2R9ANK1|||http://purl.uniprot.org/uniprot/A0A2R9ANK8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB5 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:PGM2L1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9G5 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/9597:IRX6 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/IRO homeobox family.|||Nucleus http://togogenome.org/gene/9597:PFDN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A886 ^@ Function|||Similarity ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. http://togogenome.org/gene/9597:LOC100985067 ^@ http://purl.uniprot.org/uniprot/A0A2R9AU08 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:SCGN ^@ http://purl.uniprot.org/uniprot/A0A2R9ANV7 ^@ Subcellular Location Annotation ^@ secretory vesicle membrane http://togogenome.org/gene/9597:TOE1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CR55 ^@ Similarity ^@ Belongs to the CAF1 family. http://togogenome.org/gene/9597:TSPAN13 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9597:LRRC8A ^@ http://purl.uniprot.org/uniprot/A0A2R9CN78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:MED7 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSH4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 7 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9597:ETS1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:KIF14 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z602 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9597:SLC35B4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BBZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/9597:NRP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4B1 ^@ Caution|||Similarity ^@ Belongs to the neuropilin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:ZFP90 ^@ http://purl.uniprot.org/uniprot/A0A2R9B6R8 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:LOC100974973 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQS1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9597:KMO ^@ http://purl.uniprot.org/uniprot/A0A2R9ADQ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aromatic-ring hydroxylase family. KMO subfamily.|||Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.|||Mitochondrion outer membrane http://togogenome.org/gene/9597:LRRC8E ^@ http://purl.uniprot.org/uniprot/A0A2R9BKS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:E2F4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZB04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9597:ZNF124 ^@ http://purl.uniprot.org/uniprot/A0A2R9ATA1 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:SMC1A ^@ http://purl.uniprot.org/uniprot/A0A2R9CBK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC1 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/9597:C6H6orf89 ^@ http://purl.uniprot.org/uniprot/A0A2R9CBD6|||http://purl.uniprot.org/uniprot/A0A2R9CDX3 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:CXCL5 ^@ http://purl.uniprot.org/uniprot/A0A2R9B6D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9597:LOC100980531 ^@ http://purl.uniprot.org/uniprot/A0A2R9A5S2|||http://purl.uniprot.org/uniprot/A0A2R9CBS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9597:LOC100980803 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFE4 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9597:ZC3HC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CQR1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:RSBN1L ^@ http://purl.uniprot.org/uniprot/A0A2R9AC68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the round spermatid basic protein 1 family.|||Nucleus http://togogenome.org/gene/9597:KAT6B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZD29 ^@ Similarity ^@ Belongs to the MYST (SAS/MOZ) family. http://togogenome.org/gene/9597:WARS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AVZ7 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9597:RALY ^@ http://purl.uniprot.org/uniprot/A0A2R9B3Y0|||http://purl.uniprot.org/uniprot/A0A2R9B8X9 ^@ Similarity ^@ Belongs to the RRM HNRPC family. RALY subfamily. http://togogenome.org/gene/9597:MTFR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACU4|||http://purl.uniprot.org/uniprot/A0A2R9AHU2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission. http://togogenome.org/gene/9597:GMNN ^@ http://purl.uniprot.org/uniprot/A0A2R9C717 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the geminin family.|||Nucleus http://togogenome.org/gene/9597:TEKT5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTC2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/9597:CTSV ^@ http://purl.uniprot.org/uniprot/A0A2R9C6I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9597:TRNT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CS35 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/9597:GRPR ^@ http://purl.uniprot.org/uniprot/A0A2R9B7E7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:CSAD ^@ http://purl.uniprot.org/uniprot/A0A2R9CB49 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/9597:CDC42BPA ^@ http://purl.uniprot.org/uniprot/A0A2R9AEW0|||http://purl.uniprot.org/uniprot/A0A2R9AEW7|||http://purl.uniprot.org/uniprot/A0A2R9AEX3|||http://purl.uniprot.org/uniprot/A0A2R9AFX2|||http://purl.uniprot.org/uniprot/A0A2R9AJS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.|||Cytoplasm|||lamellipodium http://togogenome.org/gene/9597:ASTL ^@ http://purl.uniprot.org/uniprot/A0A2R9AP69 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:EMC3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5S0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC3 family.|||Component of the ER membrane protein complex (EMC).|||Membrane http://togogenome.org/gene/9597:ZFYVE16 ^@ http://purl.uniprot.org/uniprot/A0A2R9BVI6 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Early endosome membrane http://togogenome.org/gene/9597:RAB33B ^@ http://purl.uniprot.org/uniprot/A0A2R9CHS4 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Rab family. http://togogenome.org/gene/9597:MSR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BBT3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:IDS ^@ http://purl.uniprot.org/uniprot/A0A2R9BWW8|||http://purl.uniprot.org/uniprot/A0A2R9C0B2 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9597:FAM221B ^@ http://purl.uniprot.org/uniprot/A0A2R9AYK1 ^@ Similarity ^@ Belongs to the FAM221 family. http://togogenome.org/gene/9597:TAS2R42 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZS79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9597:TAF9B ^@ http://purl.uniprot.org/uniprot/A0A2R9CFB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF9 family.|||Nucleus http://togogenome.org/gene/9597:GRIK3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A703 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9597:BRIX1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BLW0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BRX1 family.|||Required for biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/9597:RRAGD ^@ http://purl.uniprot.org/uniprot/A0A2R9A8P0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/9597:SLCO1B1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AN29 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:NEXMIF ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFQ1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:ENGASE ^@ http://purl.uniprot.org/uniprot/A0A2R9C2L2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 85 family.|||cytosol http://togogenome.org/gene/9597:CP ^@ http://purl.uniprot.org/uniprot/A0A2R9AYC2 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/9597:SLC16A14 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSF2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:SMC5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBS8|||http://purl.uniprot.org/uniprot/A0A2R8ZFB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC5 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/9597:CTPS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A533 ^@ Function|||Similarity ^@ Belongs to the CTP synthase family.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. http://togogenome.org/gene/9597:FAM151A ^@ http://purl.uniprot.org/uniprot/A0A2R9A2C3 ^@ Similarity ^@ Belongs to the FAM151 family. http://togogenome.org/gene/9597:BLOC1S2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CI40|||http://purl.uniprot.org/uniprot/A0A2R9CRI6 ^@ Similarity ^@ Belongs to the BLOC1S2 family. http://togogenome.org/gene/9597:MIS18A ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6H4 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.|||centromere http://togogenome.org/gene/9597:CAB39L ^@ http://purl.uniprot.org/uniprot/A0A2R9A8T9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mo25 family.|||Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.|||Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. http://togogenome.org/gene/9597:MRPL20 ^@ http://purl.uniprot.org/uniprot/A0A2R9CBN9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family. http://togogenome.org/gene/9597:RPL14 ^@ http://purl.uniprot.org/uniprot/A0A2R9A518 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL14 family. http://togogenome.org/gene/9597:SLC22A8 ^@ http://purl.uniprot.org/uniprot/A0A2R9C641 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.|||Cell membrane http://togogenome.org/gene/9597:BNIP3L ^@ http://purl.uniprot.org/uniprot/A0A2R9BDM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIP3 family.|||Membrane http://togogenome.org/gene/9597:ALDH3A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CHQ4 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9597:XPOT ^@ http://purl.uniprot.org/uniprot/A0A2R9AGR5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus|||tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. http://togogenome.org/gene/9597:CCNB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CK63 ^@ Function|||Similarity ^@ Belongs to the cyclin family.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition. http://togogenome.org/gene/9597:ALDOB ^@ http://purl.uniprot.org/uniprot/A0A2R9BPJ9 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/9597:LOC100991964 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZL15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9597:SLCO6A1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPZ1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:POU4F2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B3T6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/9597:LOC100988087 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6Q1 ^@ Similarity ^@ Belongs to the PRR23 family. http://togogenome.org/gene/9597:POP4 ^@ http://purl.uniprot.org/uniprot/A0A2R9C2Q3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 1 family.|||Component of nuclear RNase P and RNase MRP.|||Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.|||nucleolus http://togogenome.org/gene/9597:LIX1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B1J2 ^@ Similarity ^@ Belongs to the LIX1 family. http://togogenome.org/gene/9597:PEX14 ^@ http://purl.uniprot.org/uniprot/A0A2R9BLZ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-14 family.|||Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.|||Peroxisome membrane http://togogenome.org/gene/9597:MRRF ^@ http://purl.uniprot.org/uniprot/A0A2R9CH14 ^@ Function|||Similarity ^@ Belongs to the RRF family.|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/9597:CCDC86 ^@ http://purl.uniprot.org/uniprot/A0A2R9CMT4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:CD38 ^@ http://purl.uniprot.org/uniprot/A0A2R9BE63 ^@ Similarity ^@ Belongs to the ADP-ribosyl cyclase family. http://togogenome.org/gene/9597:GPD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AFW8 ^@ Function|||Similarity ^@ Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.|||Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device. http://togogenome.org/gene/9597:LOC100982159 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSL5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:CACNB2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AUD3|||http://purl.uniprot.org/uniprot/A0A2R9AUF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||sarcolemma http://togogenome.org/gene/9597:HBP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CA46 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4. http://togogenome.org/gene/9597:TGFB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AI79 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.|||extracellular matrix http://togogenome.org/gene/9597:NLRP3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCP5 ^@ Similarity ^@ Belongs to the NLRP family. http://togogenome.org/gene/9597:TAS2R8 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZG54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9597:ISCA2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HesB/IscA family.|||Mitochondrion http://togogenome.org/gene/9597:ALKBH1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7C9 ^@ Cofactor|||Similarity ^@ Belongs to the alkB family.|||Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/9597:HMGB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AAV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/9597:SLC11A2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BRS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NRAMP family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/9597:ASB7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BHT5 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9597:FOXS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ARS5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:FGFR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AGY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.|||Cell membrane|||Cytoplasmic vesicle|||Membrane|||Nucleus|||Vesicle|||cytosol http://togogenome.org/gene/9597:MDM4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AGQ3|||http://purl.uniprot.org/uniprot/A0A2R9AHJ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM2/MDM4 family.|||Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.|||Nucleus http://togogenome.org/gene/9597:PDCD10 ^@ http://purl.uniprot.org/uniprot/A0A2R9AWY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDCD10 family.|||Cell membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:DYNLRB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AEC3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.|||Belongs to the GAMAD family.|||Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.|||cytoskeleton http://togogenome.org/gene/9597:NR1H3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BV37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9597:GLE1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AY79 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GLE1 family.|||Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/9597:SDR16C5 ^@ http://purl.uniprot.org/uniprot/A0A2R9AMV2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9597:NKG7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/9597:CPSF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BVW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.|||Nucleus http://togogenome.org/gene/9597:GRIA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BL79|||http://purl.uniprot.org/uniprot/A0A2R9BPR9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9597:TRMT13 ^@ http://purl.uniprot.org/uniprot/A0A2R9CSI6 ^@ Function|||Similarity ^@ Belongs to the methyltransferase TRM13 family.|||tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His). http://togogenome.org/gene/9597:GNGT2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZX90 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9597:KIF2A ^@ http://purl.uniprot.org/uniprot/A0A2R9AXG0|||http://purl.uniprot.org/uniprot/A0A2R9AXY9 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9597:PF4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BF33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9597:CDO1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CIL3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the cysteine dioxygenase family.|||Binds 1 Fe cation per subunit.|||Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen. http://togogenome.org/gene/9597:ATAD2B ^@ http://purl.uniprot.org/uniprot/A0A2R9AS78 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9597:RHBDL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7U2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S54 family.|||Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.|||Membrane http://togogenome.org/gene/9597:GASK1A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHQ5 ^@ Similarity ^@ Belongs to the GASK family. http://togogenome.org/gene/9597:CKS1B ^@ http://purl.uniprot.org/uniprot/A0A2R9BR08 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.|||Forms a homohexamer that can probably bind six kinase subunits. http://togogenome.org/gene/9597:ZDHHC24 ^@ http://purl.uniprot.org/uniprot/A0A2R9CQD4 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9597:ABAT ^@ http://purl.uniprot.org/uniprot/A0A2R8Z656 ^@ Similarity|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9597:TSPO ^@ http://purl.uniprot.org/uniprot/A0A2R8ZE54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TspO/BZRP family.|||Membrane http://togogenome.org/gene/9597:CYRIB ^@ http://purl.uniprot.org/uniprot/A0A2R9CCT6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CYRI family.|||Interacts with RAC1 (GTP-bound form preferentially).|||Membrane http://togogenome.org/gene/9597:MLH1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AM85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||Nucleus http://togogenome.org/gene/9597:JPT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A552|||http://purl.uniprot.org/uniprot/A0A2R9AAF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:LOC100987067 ^@ http://purl.uniprot.org/uniprot/A0A2R9AKJ6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:LOC100969667 ^@ http://purl.uniprot.org/uniprot/A0A2R9ARN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:SEMA3G ^@ http://purl.uniprot.org/uniprot/A0A2R9ASH9 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:ZNF558 ^@ http://purl.uniprot.org/uniprot/A0A2R9BBF3 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:SLC7A9 ^@ http://purl.uniprot.org/uniprot/A0A2R9C2F7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:POU5F2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZF34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/9597:ZNF764 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABZ5 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:SMIM15 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM15 family.|||Membrane http://togogenome.org/gene/9597:JUP ^@ http://purl.uniprot.org/uniprot/A0A2R9C352 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-catenin family.|||adherens junction http://togogenome.org/gene/9597:LOC100990425 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZE65 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:PEX19 ^@ http://purl.uniprot.org/uniprot/A0A2R9BPY5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxin-19 family.|||Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.|||Membrane|||Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.|||Peroxisome membrane http://togogenome.org/gene/9597:PRKAR1B ^@ http://purl.uniprot.org/uniprot/A0A2R9BW82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:ZNF627 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1Y3 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:RND3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CCZ2 ^@ Function ^@ Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. http://togogenome.org/gene/9597:CD79A ^@ http://purl.uniprot.org/uniprot/A0A2R9BXX2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:EIF4G1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CEB6 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4G family. http://togogenome.org/gene/9597:CDH5 ^@ http://purl.uniprot.org/uniprot/A0A2R9B8B3 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:RPL39 ^@ http://purl.uniprot.org/uniprot/A0A2R9CE33 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/9597:NCK1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1S6 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Endoplasmic reticulum http://togogenome.org/gene/9597:WT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B171 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Cytoplasm|||Nucleus speckle http://togogenome.org/gene/9597:TMEM18 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM18 family.|||Membrane|||Nucleus membrane http://togogenome.org/gene/9597:ADAM17 ^@ http://purl.uniprot.org/uniprot/A0A2R9BL62 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:NAP1L1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CHV5 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9597:AGPAT3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AA44 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9597:OLR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSS2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:POLR2I ^@ http://purl.uniprot.org/uniprot/A0A2R9ATB7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/9597:CHCHD4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQL3|||http://purl.uniprot.org/uniprot/A0A2R9AWT2 ^@ Subcellular Location Annotation ^@ Mitochondrion intermembrane space http://togogenome.org/gene/9597:CDC73 ^@ http://purl.uniprot.org/uniprot/A0A2R9B3T2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC73 family.|||Nucleus http://togogenome.org/gene/9597:CMTM8 ^@ http://purl.uniprot.org/uniprot/A0A2R9AGV2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:GK2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FGGY kinase family.|||Cytoplasm http://togogenome.org/gene/9597:NDUFAF3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BLA4 ^@ Function|||Subcellular Location Annotation ^@ Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).|||Membrane|||Mitochondrion inner membrane|||Nucleus http://togogenome.org/gene/9597:LOC100983724 ^@ http://purl.uniprot.org/uniprot/A0A2R9APD7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:TNPO2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIF0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:NEDD9 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1Z2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAS family.|||focal adhesion http://togogenome.org/gene/9597:DDX6 ^@ http://purl.uniprot.org/uniprot/A0A2R9B387 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9597:PDCL ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQ76 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9597:LHFPL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B1N4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:OTOG ^@ http://purl.uniprot.org/uniprot/A0A2R8ZW83|||http://purl.uniprot.org/uniprot/A0A2R8ZW98 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:MRGPRX3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCA6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9597:GTF2F2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B7Z8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIF beta subunit family.|||Nucleus|||TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. http://togogenome.org/gene/9597:CILP ^@ http://purl.uniprot.org/uniprot/A0A2R9CE12 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9597:KCNMB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSK9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KCNMB (TC 8.A.14.1) family.|||Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.|||Membrane|||N-glycosylated.|||Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. http://togogenome.org/gene/9597:ERG ^@ http://purl.uniprot.org/uniprot/A0A2R9ACP1|||http://purl.uniprot.org/uniprot/A0A2R9ACP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9597:ODF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJY7 ^@ Function ^@ Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. http://togogenome.org/gene/9597:NOP16 ^@ http://purl.uniprot.org/uniprot/A0A2R9B8U2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP16 family.|||nucleolus http://togogenome.org/gene/9597:ZPR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BCU3 ^@ Similarity ^@ Belongs to the ZPR1 family. http://togogenome.org/gene/9597:ACVR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BMX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9597:UBE2T ^@ http://purl.uniprot.org/uniprot/A0A2R9B0J5 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9597:TBCC ^@ http://purl.uniprot.org/uniprot/A0A2R8Z8R5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TBCC family.|||Cytoplasm|||Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state. http://togogenome.org/gene/9597:PEX12 ^@ http://purl.uniprot.org/uniprot/A0A2R9BAF6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pex2/pex10/pex12 family.|||Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9597:POLR3F ^@ http://purl.uniprot.org/uniprot/A0A2R9BKK2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/9597:ZNF284 ^@ http://purl.uniprot.org/uniprot/A0A2R9AK22 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:PENK ^@ http://purl.uniprot.org/uniprot/A0A2R9CRY2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the opioid neuropeptide precursor family.|||Increases glutamate release in the striatum and decreases GABA concentration in the striatum.|||Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.|||Secreted|||chromaffin granule lumen http://togogenome.org/gene/9597:SESN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C8E7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/9597:USP2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZT66|||http://purl.uniprot.org/uniprot/A0A2R8ZXT1 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9597:PIANP ^@ http://purl.uniprot.org/uniprot/A0A2R9A3V8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:SULT1C4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BNR2 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9597:IL17A ^@ http://purl.uniprot.org/uniprot/A0A2R9A141 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/9597:MRPS17 ^@ http://purl.uniprot.org/uniprot/A0A2R9BKT7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/9597:GTF2H3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BXP6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB4 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.|||Nucleus|||Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7. http://togogenome.org/gene/9597:LOC100975166 ^@ http://purl.uniprot.org/uniprot/A0A2R9C8K5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS10 family. http://togogenome.org/gene/9597:SAMD8 ^@ http://purl.uniprot.org/uniprot/A0A2R9B5P3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/9597:LOC100982859 ^@ http://purl.uniprot.org/uniprot/A0A220QK08 ^@ Similarity|||Subunit ^@ Belongs to the MHC class I family.|||Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). http://togogenome.org/gene/9597:WRN ^@ http://purl.uniprot.org/uniprot/A0A2R9BLV2 ^@ Similarity ^@ Belongs to the helicase family. RecQ subfamily. http://togogenome.org/gene/9597:LAMTOR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C3K6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR1 family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/9597:EIF4A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C6F8 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family. eIF4A subfamily.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9597:CD74 ^@ http://purl.uniprot.org/uniprot/A0A2R9BGX4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:ATP6V1E2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ARI0 ^@ Similarity ^@ Belongs to the V-ATPase E subunit family. http://togogenome.org/gene/9597:MCCC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CTB8 ^@ Similarity ^@ Belongs to the AccD/PCCB family. http://togogenome.org/gene/9597:TEF ^@ http://purl.uniprot.org/uniprot/A0A2R9B9E5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/9597:TIMM9 ^@ http://purl.uniprot.org/uniprot/A0A2R9A0P7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9597:SRP68 ^@ http://purl.uniprot.org/uniprot/A0A2R9A348 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP68 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.|||Cytoplasm|||nucleolus http://togogenome.org/gene/9597:BUD31 ^@ http://purl.uniprot.org/uniprot/A0A2R9C277 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BUD31 (G10) family.|||Nucleus http://togogenome.org/gene/9597:INA ^@ http://purl.uniprot.org/uniprot/A0A2R9BN98 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9597:HNRNPK ^@ http://purl.uniprot.org/uniprot/A0A2R9CSP4 ^@ Subcellular Location Annotation ^@ Cytoplasm|||nucleoplasm|||podosome http://togogenome.org/gene/9597:MMUT ^@ http://purl.uniprot.org/uniprot/A0A2R9B0C4 ^@ Function|||Similarity ^@ Belongs to the methylmalonyl-CoA mutase family.|||Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle. http://togogenome.org/gene/9597:TMEM88 ^@ http://purl.uniprot.org/uniprot/A0A2R9B5I2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM88 family.|||Membrane http://togogenome.org/gene/9597:FMR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CAG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMR1 family.|||Cell membrane|||Cytoplasmic ribonucleoprotein granule|||Membrane|||Perikaryon|||Presynaptic cell membrane|||Stress granule|||Synaptic cell membrane|||axon|||centromere|||dendrite|||dendritic spine|||filopodium tip|||growth cone|||neuron projection|||nucleolus|||perinuclear region|||synaptosome http://togogenome.org/gene/9597:PHYHIP ^@ http://purl.uniprot.org/uniprot/A0A2R9A0U4 ^@ Similarity ^@ Belongs to the PHYHIP family. http://togogenome.org/gene/9597:DBX2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BB85 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:UBE2E3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A2H1 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9597:MGAT4D ^@ http://purl.uniprot.org/uniprot/A0A2R9BC67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 54 family.|||Golgi apparatus membrane http://togogenome.org/gene/9597:PGAM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1H4 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/9597:PLK2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BY27 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. http://togogenome.org/gene/9597:ATP8B1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CHA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9597:ADAM10 ^@ http://purl.uniprot.org/uniprot/A0A2R9C3C4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:GART ^@ http://purl.uniprot.org/uniprot/A0A2R9AA76 ^@ Similarity ^@ In the C-terminal section; belongs to the GART family.|||In the N-terminal section; belongs to the GARS family.|||In the central section; belongs to the AIR synthase family. http://togogenome.org/gene/9597:NUP93 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYX4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin interacting component (NIC) family.|||Nucleus membrane|||Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.|||nuclear pore complex http://togogenome.org/gene/9597:ANO5 ^@ http://purl.uniprot.org/uniprot/A0A2R9AG47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:YWHAZ ^@ http://purl.uniprot.org/uniprot/A0A2R9BQD0 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9597:LOC100969317 ^@ http://purl.uniprot.org/uniprot/A0A2R9AMX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:TSG101 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQ37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.|||Membrane http://togogenome.org/gene/9597:USB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CAG8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 2H phosphoesterase superfamily. USB1 family.|||Nucleus|||Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. http://togogenome.org/gene/9597:NLK ^@ http://purl.uniprot.org/uniprot/A0A2R9AE67 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9597:SLC25A43 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9597:ABCC5 ^@ http://purl.uniprot.org/uniprot/A0A2R9AB62 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:INHA ^@ http://purl.uniprot.org/uniprot/A0A2R9CFY0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.|||Secreted http://togogenome.org/gene/9597:TCN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CAU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic cobalamin transport proteins family.|||Secreted http://togogenome.org/gene/9597:ARRDC3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B0Y9 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9597:APH1A ^@ http://purl.uniprot.org/uniprot/A0A2R9ASX7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the APH-1 family.|||Component of the gamma-secretase complex.|||Membrane|||Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. http://togogenome.org/gene/9597:RPE65 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDI3 ^@ Cofactor|||Similarity ^@ Belongs to the carotenoid oxygenase family.|||Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/9597:ROPN1L ^@ http://purl.uniprot.org/uniprot/A0A2R9A084 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ropporin family.|||flagellum http://togogenome.org/gene/9597:SIM1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHR3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:ZHX1 ^@ http://purl.uniprot.org/uniprot/A1YG99 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins (By similarity).|||Belongs to the ZHX family.|||Forms homodimers. Heterodimer (via HD1 domain) with ZHX2 (via HD1 domain). Also forms a heterodimer with ZHX3 which is a prerequisite for repressor activity. Interacts with ATF7IP and NFYA. Interacts (via homeobox domains) with DNMT3B (via PWWP domain) (By similarity).|||Nucleus http://togogenome.org/gene/9597:CCL19 ^@ http://purl.uniprot.org/uniprot/A0A2R9ARU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9597:AASDHPPT ^@ http://purl.uniprot.org/uniprot/A0A2R9AEU1 ^@ Similarity ^@ Belongs to the P-Pant transferase superfamily. AcpS family. http://togogenome.org/gene/9597:NOL10 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat NOL10/ENP2 family.|||nucleolus http://togogenome.org/gene/9597:IZUMO1R ^@ http://purl.uniprot.org/uniprot/A0A2R9C5Y0 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/9597:SLC35C1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BVS0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:DTWD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AVC9 ^@ Similarity ^@ Belongs to the TDD superfamily. DTWD2 family. http://togogenome.org/gene/9597:HOXB7 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9597:LIX1L ^@ http://purl.uniprot.org/uniprot/A0A2R9BTI3 ^@ Similarity ^@ Belongs to the LIX1 family. http://togogenome.org/gene/9597:ITIH5 ^@ http://purl.uniprot.org/uniprot/A0A2R9CE35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/9597:HNF1B ^@ http://purl.uniprot.org/uniprot/A0A2R9C2Z9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HNF1 homeobox family.|||Nucleus http://togogenome.org/gene/9597:LOC106634670 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCC0 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9597:ZNF41 ^@ http://purl.uniprot.org/uniprot/A0A2R9B6G9 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:ZNF649 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSF8 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:CNTNAP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A2M7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||paranodal septate junction http://togogenome.org/gene/9597:DCTN4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BKJ4|||http://purl.uniprot.org/uniprot/A0A2R9BQG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunit 4 family.|||cell cortex|||centrosome|||sarcomere|||stress fiber http://togogenome.org/gene/9597:VAMP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B198 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9597:SEC13 ^@ http://purl.uniprot.org/uniprot/A0A2R9CFF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||Lysosome membrane http://togogenome.org/gene/9597:ZSCAN26 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIE1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:CRABP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZL11 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9597:MAB21L3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BGG0 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9597:NHS ^@ http://purl.uniprot.org/uniprot/A0A2R9AJ71|||http://purl.uniprot.org/uniprot/A0A2R9ARC7 ^@ Similarity ^@ Belongs to the NHS family. http://togogenome.org/gene/9597:ZP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B9H1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZP domain family. ZPB subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Zona pellucida http://togogenome.org/gene/9597:NCAPG ^@ http://purl.uniprot.org/uniprot/A0A2R9A1B9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CND3 (condensin subunit 3) family.|||Chromosome http://togogenome.org/gene/9597:BORCS8 ^@ http://purl.uniprot.org/uniprot/A0A2R9B0V0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS8 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9597:CRIPTO ^@ http://purl.uniprot.org/uniprot/A0A2R9ACX4 ^@ Caution|||Similarity ^@ Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:LOC100971436 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNF0 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/9597:LOC100984505 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTY9 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:LOC100977130 ^@ http://purl.uniprot.org/uniprot/A0A2R9B5U7|||http://purl.uniprot.org/uniprot/A0A2R9B8G5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9597:SPTAN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BH53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the spectrin family.|||cell cortex|||cytoskeleton http://togogenome.org/gene/9597:LOC100978630 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine gamma family.|||Secreted http://togogenome.org/gene/9597:DUSP4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/9597:FGD6 ^@ http://purl.uniprot.org/uniprot/A0A2R9CI86 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9597:CDKAL1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMJ9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methylthiotransferase family. CDKAL1 subfamily.|||Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9597:IMPA2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGM8 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/9597:SRD5A3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A807 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).|||Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.|||Endoplasmic reticulum membrane|||Membrane|||Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. http://togogenome.org/gene/9597:MCM7 ^@ http://purl.uniprot.org/uniprot/A0A2R9B174 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Nucleus http://togogenome.org/gene/9597:TFRC ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIZ5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.|||Homodimer; disulfide-linked.|||Melanosome|||Membrane|||Stearoylated. http://togogenome.org/gene/9597:ZNF184 ^@ http://purl.uniprot.org/uniprot/A0A2R9C8X5 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:SF3B6 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1Q4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:TAF13 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUH2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:LOC100969890 ^@ http://purl.uniprot.org/uniprot/A0A2R9C1A7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase IV family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9597:LOC100970658 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9597:CAVIN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C964 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/9597:DUXB ^@ http://purl.uniprot.org/uniprot/A0A2R9A4N4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:TLR3 ^@ http://purl.uniprot.org/uniprot/B3Y621 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9597:TSC22D1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BWG4|||http://purl.uniprot.org/uniprot/A0A2R9BWH4 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/9597:MAP2K1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A4U3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:PAMR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZP49|||http://purl.uniprot.org/uniprot/A0A2R8ZQC7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:QNG1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZH7 ^@ Function|||Similarity ^@ Belongs to the QNG1 protein family.|||Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly. http://togogenome.org/gene/9597:SPTLC2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTG0 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9597:IL4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVJ1|||http://purl.uniprot.org/uniprot/A0A2R8ZXQ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-4/IL-13 family.|||Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.|||Secreted http://togogenome.org/gene/9597:CLDN3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHZ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the claudin family.|||Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9597:PIGK ^@ http://purl.uniprot.org/uniprot/A0A2R9BWH2 ^@ Similarity|||Subunit ^@ Belongs to the peptidase C13 family.|||Forms a complex with PIGT, PIGS, PIGU and GAA1. http://togogenome.org/gene/9597:SCRN1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIV2 ^@ Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily. http://togogenome.org/gene/9597:ZNF45 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z888 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:TYMS ^@ http://purl.uniprot.org/uniprot/A0A2R9BCN0 ^@ Similarity ^@ Belongs to the thymidylate synthase family. http://togogenome.org/gene/9597:RPL9 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDD2 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/9597:DUS4L ^@ http://purl.uniprot.org/uniprot/A0A2R9AM37 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. http://togogenome.org/gene/9597:AADACL2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZ56 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/9597:VIM ^@ http://purl.uniprot.org/uniprot/A0A2R9BXN0 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9597:IGF1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZF45|||http://purl.uniprot.org/uniprot/A0A2R8ZF48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/9597:TG ^@ http://purl.uniprot.org/uniprot/A0A2R9AW86 ^@ Caution|||Similarity ^@ Belongs to the type-B carboxylesterase/lipase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:TMBIM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AYE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9597:ELOVL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDD6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ELO family. ELOVL1 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.|||Endoplasmic reticulum membrane|||Interacts with LASS2, TECR and HSD17B12.|||Membrane|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9597:AP1M2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDJ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Golgi apparatus|||Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9597:PISD ^@ http://purl.uniprot.org/uniprot/A0A2R9C6P1|||http://purl.uniprot.org/uniprot/A0A2R9CH99 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.|||Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:PSMD5 ^@ http://purl.uniprot.org/uniprot/A0A2R9C0K4 ^@ Similarity ^@ Belongs to the proteasome subunit S5B/HSM3 family. http://togogenome.org/gene/9597:ATPAF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AH11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP12 family.|||Mitochondrion http://togogenome.org/gene/9597:MPC1L ^@ http://purl.uniprot.org/uniprot/A0A2R8ZL99 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9597:ZNF684 ^@ http://purl.uniprot.org/uniprot/A0A2R9AEE5 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:ILDR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CLH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. LISCH7 family.|||Membrane|||tight junction http://togogenome.org/gene/9597:CASP10 ^@ http://purl.uniprot.org/uniprot/A0A2R9CBU0|||http://purl.uniprot.org/uniprot/A0A2R9CEB3 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9597:NFX1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZWK3|||http://purl.uniprot.org/uniprot/A0A2R8ZXQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NFX1 family.|||Nucleus http://togogenome.org/gene/9597:SCARF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AUW3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:FHL5 ^@ http://purl.uniprot.org/uniprot/A0A2R9BEN0 ^@ Function|||Subcellular Location Annotation ^@ May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.|||Nucleus http://togogenome.org/gene/9597:DNAJC25 ^@ http://purl.uniprot.org/uniprot/A0A2R9C1Z6 ^@ Similarity ^@ Belongs to the DNAJC25 family. http://togogenome.org/gene/9597:MYO19 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXU1 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9597:SYS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUQ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SYS1 family.|||Golgi apparatus membrane|||Interacts with ARFRP1.|||Involved in protein trafficking. May serve as a receptor for ARFRP1.|||Membrane http://togogenome.org/gene/9597:ST7L ^@ http://purl.uniprot.org/uniprot/A0A2R9BHE9|||http://purl.uniprot.org/uniprot/A0A2R9BHF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ST7 family.|||Membrane http://togogenome.org/gene/9597:SLC30A6 ^@ http://purl.uniprot.org/uniprot/A0A2R9BLV1|||http://purl.uniprot.org/uniprot/A0A2R9BV01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9597:FITM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ANF5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FIT family. FIT1 subfamily.|||Endoplasmic reticulum membrane|||Membrane|||Plays an important role in the formation of lipid droplets (LDs), which are storage organelles at the center of lipid and energy homeostasis. Directly binds to diacylglycerol (DAGs) and triacylglycerol. http://togogenome.org/gene/9597:CA3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CFW9 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9597:CASP7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BDG5|||http://purl.uniprot.org/uniprot/A0A2R9BHA8 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9597:DENND5B ^@ http://purl.uniprot.org/uniprot/A0A2R8Z705 ^@ Caution|||Similarity ^@ Belongs to the RAB6IP1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:ASPM ^@ http://purl.uniprot.org/uniprot/A0A2R9CCV8|||http://purl.uniprot.org/uniprot/A0A2R9CFH3 ^@ Subcellular Location Annotation ^@ Nucleus|||spindle http://togogenome.org/gene/9597:LOC100978332 ^@ http://purl.uniprot.org/uniprot/A0A2R9AY18 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. http://togogenome.org/gene/9597:PPIL6 ^@ http://purl.uniprot.org/uniprot/A0A2R9CH22 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9597:STT3A ^@ http://purl.uniprot.org/uniprot/A0A2R9BZA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/9597:TTC21B ^@ http://purl.uniprot.org/uniprot/A0A2R9BJI3 ^@ Similarity ^@ Belongs to the TTC21 family. http://togogenome.org/gene/9597:MFN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CKI6 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9597:HOXB6 ^@ http://purl.uniprot.org/uniprot/A0A2R9ALG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9597:MALSU1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9K7 ^@ Similarity ^@ Belongs to the Iojap/RsfS family. http://togogenome.org/gene/9597:WSCD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ATF8 ^@ Function|||Similarity ^@ Belongs to the WSCD family.|||Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans. http://togogenome.org/gene/9597:SNU13 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZRL7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/9597:UTP6 ^@ http://purl.uniprot.org/uniprot/A0A2R9BKI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP6 family.|||nucleolus http://togogenome.org/gene/9597:PKN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cleavage furrow|||Midbody|||Nucleus http://togogenome.org/gene/9597:LOC100973583 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MHC class II family.|||Endosome membrane|||Lysosome membrane http://togogenome.org/gene/9597:RPS12 ^@ http://purl.uniprot.org/uniprot/A0A2R9CR19 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS12 family. http://togogenome.org/gene/9597:PFAS ^@ http://purl.uniprot.org/uniprot/A0A2R8ZP75 ^@ Similarity ^@ In the N-terminal section; belongs to the FGAMS family. http://togogenome.org/gene/9597:OOSP2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PLAC1 family.|||Secreted http://togogenome.org/gene/9597:ERC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZ11|||http://purl.uniprot.org/uniprot/A0A2R9B2T2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:SRPRB ^@ http://purl.uniprot.org/uniprot/A0A2R8ZST4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP receptor beta subunit family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:SNAP23 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP-25 family.|||Cell membrane|||Membrane|||synaptosome http://togogenome.org/gene/9597:ATF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BP84 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:HS3ST2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B8Q8 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9597:RPL36 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZWN1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL36 family. http://togogenome.org/gene/9597:RIC8B ^@ http://purl.uniprot.org/uniprot/A0A2R9AME9|||http://purl.uniprot.org/uniprot/A0A2R9ATV0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the synembryn family.|||Cytoplasm|||Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.|||Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. http://togogenome.org/gene/9597:LYNX1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BDR1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:DHX8 ^@ http://purl.uniprot.org/uniprot/A0A2R9CCJ7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:HMGCR ^@ http://purl.uniprot.org/uniprot/A0A2R9B572 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMG-CoA reductase family.|||Endoplasmic reticulum membrane|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9597:A2M ^@ http://purl.uniprot.org/uniprot/A0A2R8ZXN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.|||Secreted http://togogenome.org/gene/9597:RAD17 ^@ http://purl.uniprot.org/uniprot/A0A2R9CLE8|||http://purl.uniprot.org/uniprot/A0A2R9CLG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad17/RAD24 family.|||Nucleus http://togogenome.org/gene/9597:CAMK1G ^@ http://purl.uniprot.org/uniprot/A0A2R9CCR5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:DNAJA1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZXS2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:TRAPPC2B ^@ http://purl.uniprot.org/uniprot/A0A2R9BQ93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||perinuclear region http://togogenome.org/gene/9597:HOOK1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BWC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hook family.|||cytoskeleton http://togogenome.org/gene/9597:BLOC1S1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHX5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BLOC1S1 family.|||Lysosome membrane|||May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9.|||Mitochondrion intermembrane space http://togogenome.org/gene/9597:CCND3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A185 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9597:APRT ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCU3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.|||Cytoplasm http://togogenome.org/gene/9597:GPR146 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDK9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:BEST1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1Z6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms calcium-sensitive chloride channels. Permeable to bicarbonate.|||Membrane http://togogenome.org/gene/9597:MTMR8 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEM9 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9597:HMGB2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CNQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/9597:IL7R ^@ http://purl.uniprot.org/uniprot/A0A2R9BVL0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 4 subfamily.|||Membrane|||Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).|||The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R. http://togogenome.org/gene/9597:GNA15 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5A3 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/9597:STX4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AY94 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9597:CHEK1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZM27 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily. http://togogenome.org/gene/9597:CKS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CEU3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.|||Forms a homohexamer that can probably bind six kinase subunits. http://togogenome.org/gene/9597:SARDH ^@ http://purl.uniprot.org/uniprot/A0A2R8ZS08 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/9597:ARHGEF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CGX6 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Golgi apparatus|||Vesicle|||spindle|||tight junction http://togogenome.org/gene/9597:DDX24 ^@ http://purl.uniprot.org/uniprot/A0A2R9BQ89 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9597:DPYD ^@ http://purl.uniprot.org/uniprot/A0A2R9C8R4|||http://purl.uniprot.org/uniprot/A0A2R9C8S4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the dihydropyrimidine dehydrogenase family.|||Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.|||Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. http://togogenome.org/gene/9597:PTCH2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ADQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the patched family.|||Membrane http://togogenome.org/gene/9597:S100A16 ^@ http://purl.uniprot.org/uniprot/A0A2R9CD60 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9597:RAD51 ^@ http://purl.uniprot.org/uniprot/A0A2R9CAJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Nucleus|||Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair. http://togogenome.org/gene/9597:EBPL ^@ http://purl.uniprot.org/uniprot/A0A2R9CDM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:IL24 ^@ http://purl.uniprot.org/uniprot/A0A2R9BHI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Secreted http://togogenome.org/gene/9597:ASB17 ^@ http://purl.uniprot.org/uniprot/A0A2R9BZ94 ^@ Function|||Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family.|||May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/9597:IST1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CMT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IST1 family.|||Cytoplasmic vesicle|||Nucleus envelope http://togogenome.org/gene/9597:ACTG1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BH44 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9597:MMP19 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFY2 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9597:SIGIRR ^@ http://purl.uniprot.org/uniprot/A0A2R8ZY42 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9597:GATAD2B ^@ http://purl.uniprot.org/uniprot/A0A2R9BWZ1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:SVOPL ^@ http://purl.uniprot.org/uniprot/A0A2R9AAU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/9597:TIGD6 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZA19 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:CLDN4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUG6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9597:ATE1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BVX0|||http://purl.uniprot.org/uniprot/A0A2R9C5M4 ^@ Function|||Similarity ^@ Belongs to the R-transferase family.|||Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. http://togogenome.org/gene/9597:TMEM59 ^@ http://purl.uniprot.org/uniprot/A0A2R9AUU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM59 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:CLPTM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BVV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLPTM1 family.|||Membrane http://togogenome.org/gene/9597:ZNF354C ^@ http://purl.uniprot.org/uniprot/A0A2R9C8V9 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:ITK ^@ http://purl.uniprot.org/uniprot/A0A2R9AHL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cytoplasm http://togogenome.org/gene/9597:DHX9 ^@ http://purl.uniprot.org/uniprot/A0A2R9AB38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DEAH subfamily.|||Nucleus http://togogenome.org/gene/9597:GRIA4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZR77|||http://purl.uniprot.org/uniprot/A0A2R8ZUD5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9597:RPS27A ^@ http://purl.uniprot.org/uniprot/A0A2R9B0K9 ^@ Similarity ^@ In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.|||In the N-terminal section; belongs to the ubiquitin family. http://togogenome.org/gene/9597:ARPC4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AFS6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARPC4 family.|||Cell projection|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.|||cytoskeleton http://togogenome.org/gene/9597:EMC8 ^@ http://purl.uniprot.org/uniprot/A0A2R9CBP9 ^@ Similarity ^@ Belongs to the EMC8/EMC9 family. http://togogenome.org/gene/9597:ZNF850 ^@ http://purl.uniprot.org/uniprot/A0A2R9BS37 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:PRKAR2A ^@ http://purl.uniprot.org/uniprot/A0A2R9AKR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:FREM3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A5H1 ^@ Similarity ^@ Belongs to the FRAS1 family. http://togogenome.org/gene/9597:NDRG1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLB2 ^@ Similarity ^@ Belongs to the NDRG family. http://togogenome.org/gene/9597:CCN5 ^@ http://purl.uniprot.org/uniprot/A0A2R9BBC6 ^@ Similarity ^@ Belongs to the CCN family. http://togogenome.org/gene/9597:RNF5 ^@ http://purl.uniprot.org/uniprot/A0A2R9BGT5 ^@ Domain|||Function|||Subcellular Location Annotation ^@ E3 ubiquitin-protein ligase.|||Endoplasmic reticulum membrane|||Mitochondrion membrane|||The RING-type zinc finger domain is responsible for E3 ligase activity. http://togogenome.org/gene/9597:EDNRB ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:HPS5 ^@ http://purl.uniprot.org/uniprot/A0A2R9BX44 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HPS5 family.|||Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.|||May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.|||cytosol http://togogenome.org/gene/9597:LOC100989293 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYG2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Cu-Zn superoxide dismutase family.|||Binds 1 copper ion per subunit.|||Binds 1 zinc ion per subunit.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/9597:DRAM2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ATN2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:NUDC ^@ http://purl.uniprot.org/uniprot/A0A2R8Z5V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nudC family.|||Midbody|||spindle http://togogenome.org/gene/9597:SEZ6L2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ALK9|||http://purl.uniprot.org/uniprot/A0A2R9AR31|||http://purl.uniprot.org/uniprot/A0A2R9AR39 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:MYMK ^@ http://purl.uniprot.org/uniprot/A0A2R9AL72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:CPSF4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CR90 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CPSF4/YTH1 family.|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex.|||Nucleus http://togogenome.org/gene/9597:PIERCE2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CI54 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.|||cilium axoneme http://togogenome.org/gene/9597:MND1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AN51 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MND1 family.|||Nucleus|||Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. http://togogenome.org/gene/9597:VPS36 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFN3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VPS36 family.|||Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II).|||Cytoplasm|||Endosome http://togogenome.org/gene/9597:LYZ ^@ http://purl.uniprot.org/uniprot/P61627 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 22 family.|||Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.|||Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.|||Monomer.|||Secreted http://togogenome.org/gene/9597:IGFBP6 ^@ http://purl.uniprot.org/uniprot/A0A2R9AYI0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9597:CDKN3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CGT3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family.|||May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues.|||perinuclear region http://togogenome.org/gene/9597:ADAM32 ^@ http://purl.uniprot.org/uniprot/A0A2R9AWU9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:KDELR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIU4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:IPO13 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYS1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the importin beta family.|||Cytoplasm|||Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.|||Nucleus http://togogenome.org/gene/9597:RPLP0 ^@ http://purl.uniprot.org/uniprot/A0A2R9AAE7 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL10 family.|||Ribosomal protein P0 is the functional equivalent of E.coli protein L10. http://togogenome.org/gene/9597:ATP6V1G1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZA04 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9597:TMOD3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A378 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9597:FNBP1L ^@ http://purl.uniprot.org/uniprot/A0A2R9A8H9|||http://purl.uniprot.org/uniprot/A0A2R9A8I9|||http://purl.uniprot.org/uniprot/A0A2R9ADU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNBP1 family.|||Cell membrane|||Cytoplasmic vesicle|||Membrane|||Vesicle|||cell cortex|||cytoskeleton http://togogenome.org/gene/9597:ZFP28 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYG1 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:GPKOW ^@ http://purl.uniprot.org/uniprot/A0A2R9BYJ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MOS2 family.|||Nucleus|||RNA-binding protein involved in pre-mRNA splicing. http://togogenome.org/gene/9597:CLCN6 ^@ http://purl.uniprot.org/uniprot/A0A2R9BB90 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:HMGCLL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ALA9 ^@ Similarity ^@ Belongs to the HMG-CoA lyase family. http://togogenome.org/gene/9597:IP6K2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZWR9 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9597:GCNT3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFN8 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:MED4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BPB3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 4 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9597:CCK ^@ http://purl.uniprot.org/uniprot/A0A2R8ZA42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gastrin/cholecystokinin family.|||Secreted http://togogenome.org/gene/9597:LOC100975751 ^@ http://purl.uniprot.org/uniprot/A0A2R9CMH2|||http://purl.uniprot.org/uniprot/A0A2R9CP90|||http://purl.uniprot.org/uniprot/A0A2R9CTL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9597:ERCC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CT99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RAD3/XPD subfamily.|||Nucleus http://togogenome.org/gene/9597:NTMT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BLQ4|||http://purl.uniprot.org/uniprot/A0A2R9BQA2 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. NTM1 family. http://togogenome.org/gene/9597:RPL22L1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B3J2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL22 family. http://togogenome.org/gene/9597:MIEF1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDM6 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9597:NEIL3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BAV7 ^@ Similarity ^@ Belongs to the FPG family. http://togogenome.org/gene/9597:MMP27 ^@ http://purl.uniprot.org/uniprot/A0A2R9AEQ4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9597:RPS6KA3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AC85 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9597:BMP3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C6X0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer.|||Secreted http://togogenome.org/gene/9597:CLNS1A ^@ http://purl.uniprot.org/uniprot/A0A2R9B7R3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pICln (TC 1.A.47) family.|||Nucleus http://togogenome.org/gene/9597:SULT2A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5R7 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9597:IFT43 ^@ http://purl.uniprot.org/uniprot/A0A2R9B5V4 ^@ Similarity ^@ Belongs to the IFT43 family. http://togogenome.org/gene/9597:VPS28 ^@ http://purl.uniprot.org/uniprot/A0A2R9CK01 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS28 family.|||Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.|||Membrane http://togogenome.org/gene/9597:PLA1A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZM37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9597:KCNQ5 ^@ http://purl.uniprot.org/uniprot/A0A2R9C6I5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:TBCCD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BFH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBCC family.|||centrosome|||spindle pole http://togogenome.org/gene/9597:BAG6 ^@ http://purl.uniprot.org/uniprot/A0A2R9A5H6|||http://purl.uniprot.org/uniprot/A0A2R9AA85 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).|||cytosol|||extracellular exosome http://togogenome.org/gene/9597:LOC100975448 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7W2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:SERPINF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJQ5 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9597:LOC100990096 ^@ http://purl.uniprot.org/uniprot/A0A2R9B9J3 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:FOXM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CHJ6|||http://purl.uniprot.org/uniprot/A0A2R9CKA6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:TSR2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJG2 ^@ Function|||Similarity ^@ Belongs to the TSR2 family.|||May be involved in 20S pre-rRNA processing. http://togogenome.org/gene/9597:ELL ^@ http://purl.uniprot.org/uniprot/A0A2R9A3H9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Nucleus http://togogenome.org/gene/9597:NKX2-8 ^@ http://purl.uniprot.org/uniprot/A0A2R9BXM0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:CD28 ^@ http://purl.uniprot.org/uniprot/A0A2R9B2A1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:LOC100977261 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKC5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9597:ANAPC5 ^@ http://purl.uniprot.org/uniprot/A0A2R9AX64 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APC5 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|||spindle http://togogenome.org/gene/9597:ZSCAN22 ^@ http://purl.uniprot.org/uniprot/A0A2R9AFG9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:LYAR ^@ http://purl.uniprot.org/uniprot/A0A2R9BBE0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:RASSF5 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9R2 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9597:SUPV3L1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B196 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family.|||mitochondrion nucleoid http://togogenome.org/gene/9597:CYP4F12 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZH0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9597:ALB ^@ http://purl.uniprot.org/uniprot/A0A2R9CFC1 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9597:PRPF38B ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6J4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP38 family.|||May be required for pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/9597:USP13 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZD09 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9597:SFRP4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AVJ4 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:OSBPL1A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZXG7|||http://purl.uniprot.org/uniprot/A0A2R8ZXG9 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9597:ZNF280B ^@ http://purl.uniprot.org/uniprot/A0A2R9AQT9 ^@ Function|||Subcellular Location Annotation ^@ May function as a transcription factor.|||Nucleus http://togogenome.org/gene/9597:PFN3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZI35 ^@ Similarity ^@ Belongs to the profilin family. http://togogenome.org/gene/9597:OSBPL6 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTB4 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9597:LYPD2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZM16 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:SUSD4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZH6|||http://purl.uniprot.org/uniprot/A0A2R9AZI1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:THBS3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CM69 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:METTL3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BRP7 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/9597:PLIN3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AEN6 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/9597:FFAR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZS24 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:EXOC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9J9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SEC5 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.|||Component of the exocyst complex. http://togogenome.org/gene/9597:ME1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9K1 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/9597:IGF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BAY3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.|||Secreted http://togogenome.org/gene/9597:SCNM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A7C4 ^@ Subcellular Location Annotation ^@ Nucleus speckle|||nucleoplasm http://togogenome.org/gene/9597:ANKRD34C ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCX4 ^@ Similarity ^@ Belongs to the ANKRD34 family. http://togogenome.org/gene/9597:DHFR ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTA3 ^@ Similarity ^@ Belongs to the dihydrofolate reductase family. http://togogenome.org/gene/9597:ASB6 ^@ http://purl.uniprot.org/uniprot/A0A2R9AIR0 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9597:FAM72A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZB43 ^@ Similarity ^@ Belongs to the FAM72 family. http://togogenome.org/gene/9597:GTPBP8 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQX2 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. http://togogenome.org/gene/9597:GNS ^@ http://purl.uniprot.org/uniprot/A0A2R9AU63 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Lysosome|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9597:LOC100973737 ^@ http://purl.uniprot.org/uniprot/A0A2R9BNY3 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the copper/topaquinone oxidase family.|||Contains 1 topaquinone per subunit.|||Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. http://togogenome.org/gene/9597:TTC39A ^@ http://purl.uniprot.org/uniprot/A0A2R9AH31 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/9597:TOR1AIP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUE1|||http://purl.uniprot.org/uniprot/A0A2R9A022 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TOR1AIP family.|||Membrane http://togogenome.org/gene/9597:FERMT3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B3F1 ^@ Similarity ^@ Belongs to the kindlin family. http://togogenome.org/gene/9597:GADD45A ^@ http://purl.uniprot.org/uniprot/A0A2R9CAI8 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/9597:RPF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSD1 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9597:AVPI1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ARR5 ^@ Function ^@ May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling. http://togogenome.org/gene/9597:YIPF5 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane http://togogenome.org/gene/9597:LOC100971082 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSV3 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus http://togogenome.org/gene/9597:SLC45A3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CC87 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:LOC100990610 ^@ http://purl.uniprot.org/uniprot/A0A2R9BW25 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the hcp beta-lactamase family.|||Mitochondrion intermembrane space|||Required for assembly of mitochondrial respiratory chain complexes. http://togogenome.org/gene/9597:FGFR1OP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AL85|||http://purl.uniprot.org/uniprot/A0A2R9AL94 ^@ Similarity ^@ Belongs to the SIKE family. http://togogenome.org/gene/9597:PSMC4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQT0 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9597:MTCH2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CCG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9597:FGD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CM84 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9597:AP2M1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B9X8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cell membrane|||Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.|||coated pit http://togogenome.org/gene/9597:KCND2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B1Q7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.|||Cell junction|||Cell membrane|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane|||dendrite|||dendritic spine http://togogenome.org/gene/9597:LOC100987081 ^@ http://purl.uniprot.org/uniprot/A0A2R9C8E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MHC class II family.|||Endosome membrane|||Lysosome membrane http://togogenome.org/gene/9597:KDM5B ^@ http://purl.uniprot.org/uniprot/A0A2R9C6D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JARID1 histone demethylase family.|||Nucleus http://togogenome.org/gene/9597:RAPSN ^@ http://purl.uniprot.org/uniprot/A0A2R9CCI0 ^@ Similarity ^@ Belongs to the RAPsyn family. http://togogenome.org/gene/9597:ODAM ^@ http://purl.uniprot.org/uniprot/A0A2R9AZ39 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ODAM family.|||Cytoplasm|||Interacts (via C-terminus) with ARHGEF5.|||Nucleus|||Secreted|||Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface. http://togogenome.org/gene/9597:OTP ^@ http://purl.uniprot.org/uniprot/A0A2R9CEY6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:KHDRBS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B8Q7 ^@ Similarity ^@ Belongs to the KHDRBS family. http://togogenome.org/gene/9597:ZNF331 ^@ http://purl.uniprot.org/uniprot/A0A2R9APT9 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:RPGRIP1L ^@ http://purl.uniprot.org/uniprot/A0A2R9BUT1|||http://purl.uniprot.org/uniprot/A0A2R9BUT8 ^@ Similarity ^@ Belongs to the RPGRIP1 family. http://togogenome.org/gene/9597:OS9 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZRP8|||http://purl.uniprot.org/uniprot/A0A2R8ZWD1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OS-9 family.|||Endoplasmic reticulum lumen|||Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation. http://togogenome.org/gene/9597:RPL8 ^@ http://purl.uniprot.org/uniprot/A0A2R9C8R8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/9597:C5AR2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZS57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:IMPA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AGN2 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/9597:CYFIP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CAR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYFIP family.|||synaptosome http://togogenome.org/gene/9597:P2RY1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:BGN ^@ http://purl.uniprot.org/uniprot/A0A2R9AYH9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||May be involved in collagen fiber assembly.|||extracellular matrix http://togogenome.org/gene/9597:BMP7 ^@ http://purl.uniprot.org/uniprot/A0A2R9AT21 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9597:IL17RC ^@ http://purl.uniprot.org/uniprot/A0A2R9C5R4|||http://purl.uniprot.org/uniprot/A0A2R9C5S1|||http://purl.uniprot.org/uniprot/A0A2R9C5S5|||http://purl.uniprot.org/uniprot/A0A2R9C657 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:ARHGEF7 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTS7 ^@ Subcellular Location Annotation ^@ lamellipodium http://togogenome.org/gene/9597:SLC1A2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AD14|||http://purl.uniprot.org/uniprot/A0A2R9AD19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9597:VWC2L ^@ http://purl.uniprot.org/uniprot/A0A2R9BKB5 ^@ Subcellular Location Annotation ^@ Synapse http://togogenome.org/gene/9597:SAR1A ^@ http://purl.uniprot.org/uniprot/A0A2R9AMH1 ^@ Similarity ^@ Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/9597:AXIN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXL2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:LOC100971665 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGM3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:MTRF1 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z5P1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Mitochondrion http://togogenome.org/gene/9597:LOC100969133 ^@ http://purl.uniprot.org/uniprot/A0A2R9ASC3 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/9597:PCYT1B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZXA1 ^@ Function|||Similarity ^@ Belongs to the cytidylyltransferase family.|||Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. http://togogenome.org/gene/9597:CDS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJV4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Membrane http://togogenome.org/gene/9597:LTBP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BKQ5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9597:ZNF24 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDP9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:TBPL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQ02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBP family.|||Nucleus http://togogenome.org/gene/9597:AATF ^@ http://purl.uniprot.org/uniprot/A0A2R9C8A1 ^@ Similarity ^@ Belongs to the AATF family. http://togogenome.org/gene/9597:COPS7B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZR30|||http://purl.uniprot.org/uniprot/A0A2R8ZR35 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:SPICE1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CKR0 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with CEP120.|||centriole|||spindle http://togogenome.org/gene/9597:TBP ^@ http://purl.uniprot.org/uniprot/A0A2R9AGJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBP family.|||Nucleus http://togogenome.org/gene/9597:ATP5IF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CQC9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase inhibitor family.|||Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.|||Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.|||Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.|||Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.|||Mitochondrion http://togogenome.org/gene/9597:GLIPR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BRE0 ^@ Similarity ^@ Belongs to the CRISP family. http://togogenome.org/gene/9597:NFKB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AKQ2|||http://purl.uniprot.org/uniprot/A0A2R9AST7 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9597:CHAF1B ^@ http://purl.uniprot.org/uniprot/A0A2R9ACU3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:RAD9A ^@ http://purl.uniprot.org/uniprot/A0A2R9AJH6 ^@ Similarity ^@ Belongs to the rad9 family. http://togogenome.org/gene/9597:DCBLD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABR2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:LSM7 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZS01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus http://togogenome.org/gene/9597:EML4 ^@ http://purl.uniprot.org/uniprot/A0A2R9B9Y3|||http://purl.uniprot.org/uniprot/A0A2R9BHP8 ^@ Similarity ^@ Belongs to the WD repeat EMAP family. http://togogenome.org/gene/9597:KCNK16 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJT6|||http://purl.uniprot.org/uniprot/A0A2R9CJU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9597:ZNF677 ^@ http://purl.uniprot.org/uniprot/A0A2R9CGP1 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:LOC100978046 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACM3 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9597:MRPL19 ^@ http://purl.uniprot.org/uniprot/A0A2R9C8M3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family. http://togogenome.org/gene/9597:TFIP11 ^@ http://purl.uniprot.org/uniprot/A0A2R9BQY1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFP11/STIP family.|||Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.|||Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.|||Nucleus http://togogenome.org/gene/9597:POT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BKX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the telombin family.|||Nucleus|||telomere http://togogenome.org/gene/9597:SMG5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGF6 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Plays a role in nonsense-mediated mRNA decay. http://togogenome.org/gene/9597:RPL19 ^@ http://purl.uniprot.org/uniprot/A0A2R9B688 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/9597:AQP3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CE25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:DDB2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZA47 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:RRS1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQ17 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRS1 family.|||Involved in ribosomal large subunit assembly.|||Nucleus http://togogenome.org/gene/9597:SCD5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTN7 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Membrane|||The histidine box domains are involved in binding the catalytic metal ions. http://togogenome.org/gene/9597:SYNDIG1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AD82 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9597:APOOL ^@ http://purl.uniprot.org/uniprot/A0A2R9BHR7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:ESS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESS2 family.|||Nucleus http://togogenome.org/gene/9597:MYF5 ^@ http://purl.uniprot.org/uniprot/A0A2R9A5D4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.|||Nucleus http://togogenome.org/gene/9597:ATG4D ^@ http://purl.uniprot.org/uniprot/A0A2R9AJ81 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/9597:TP53RK ^@ http://purl.uniprot.org/uniprot/A0A2R9BNQ8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. BUD32 family. http://togogenome.org/gene/9597:ZNF783 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDR9 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:SLC2A2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BVS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:CBR3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm http://togogenome.org/gene/9597:OTOP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ADD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the otopetrin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:LOC100989678 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPT0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9597:CORO6 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIE2|||http://purl.uniprot.org/uniprot/A0A2R8ZKV5 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/9597:IL13RA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BPA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 5 subfamily.|||Membrane http://togogenome.org/gene/9597:ARPC5 ^@ http://purl.uniprot.org/uniprot/A0A2R9BWR3 ^@ Function|||Similarity ^@ Belongs to the ARPC5 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. http://togogenome.org/gene/9597:DPT ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEN1 ^@ Similarity ^@ Belongs to the dermatopontin family. http://togogenome.org/gene/9597:RNFT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ASA9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:AFM ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLB9 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9597:HARS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BX99 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9597:ST8SIA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CF06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9597:PPARA ^@ http://purl.uniprot.org/uniprot/A0A2R9BY52 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.|||Nucleus http://togogenome.org/gene/9597:CSF1R ^@ http://purl.uniprot.org/uniprot/A0A2R9C866 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:ENKUR ^@ http://purl.uniprot.org/uniprot/A0A2R9BA21 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9597:SMIM24 ^@ http://purl.uniprot.org/uniprot/A0A2R9C6F6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:PIP4P1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1B6 ^@ Function|||Subcellular Location Annotation ^@ Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane|||phagosome membrane http://togogenome.org/gene/9597:SLC43A3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1I3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:SDR42E1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXU6 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9597:ZNF641 ^@ http://purl.uniprot.org/uniprot/A0A2R9CKH3 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:ZNF223 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKM0 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:WDFY1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFX3 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9597:FAM20C ^@ http://purl.uniprot.org/uniprot/A0A2R9C8J1 ^@ Similarity ^@ Belongs to the FAM20 family. http://togogenome.org/gene/9597:HDAC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AMJ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins.|||Nucleus http://togogenome.org/gene/9597:DTD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A540 ^@ Similarity ^@ Belongs to the DTD family. http://togogenome.org/gene/9597:GPRC5B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYF9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:F11R ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9597:NIFK ^@ http://purl.uniprot.org/uniprot/A0A2R9B3P2 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9597:CLCA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BHZ5 ^@ Similarity ^@ Belongs to the CLCR family. http://togogenome.org/gene/9597:PRICKLE3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4Z4 ^@ Similarity ^@ Belongs to the prickle / espinas / testin family. http://togogenome.org/gene/9597:CUL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C048 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9597:CETN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTG6 ^@ Similarity ^@ Belongs to the centrin family. http://togogenome.org/gene/9597:FABP7 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABE2 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9597:CHST12 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:ALDOA ^@ http://purl.uniprot.org/uniprot/A0A2R9BV84 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/9597:GOSR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AEH1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GOSR1 family.|||Component of several multiprotein Golgi SNARE complexes.|||Golgi apparatus membrane|||Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.|||Membrane http://togogenome.org/gene/9597:TRH ^@ http://purl.uniprot.org/uniprot/A0A2R9C4N0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRH family.|||Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.|||Secreted http://togogenome.org/gene/9597:RNF31 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZXR3 ^@ Similarity ^@ Belongs to the RBR family. http://togogenome.org/gene/9597:SLC5A7 ^@ http://purl.uniprot.org/uniprot/A0A2R9A7A0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:AMIGO3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZE50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. AMIGO family.|||Membrane http://togogenome.org/gene/9597:CAVIN4 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/9597:COG1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKL3 ^@ Similarity ^@ Belongs to the COG1 family. http://togogenome.org/gene/9597:FYTTD1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UIF family.|||Nucleus speckle|||nucleoplasm http://togogenome.org/gene/9597:TLCD4 ^@ http://purl.uniprot.org/uniprot/A0A2R9C637 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:LOC100972441 ^@ http://purl.uniprot.org/uniprot/A0A2R9AS38 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:FADS3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZW45 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:LOC100975275 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7E4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:LOC100996206 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9597:ALDH5A1 ^@ http://purl.uniprot.org/uniprot/Q3MSM4 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aldehyde dehydrogenase family.|||Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).|||Homotetramer.|||Mitochondrion|||Redox-regulated. Inhibited under oxydizing conditions (By similarity). http://togogenome.org/gene/9597:IDI2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CAI9 ^@ Function|||Similarity ^@ Belongs to the IPP isomerase type 1 family.|||Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). http://togogenome.org/gene/9597:LOC100986069 ^@ http://purl.uniprot.org/uniprot/A0A2R9AM77 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:UCK1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CFB1|||http://purl.uniprot.org/uniprot/A0A2R9CHS8 ^@ Similarity ^@ Belongs to the uridine kinase family. http://togogenome.org/gene/9597:ZKSCAN3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BX51 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9597:RPL12 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACW1 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL11 family.|||Binds directly to 26S ribosomal RNA. http://togogenome.org/gene/9597:NLE1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJ97 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9597:LOC100980635 ^@ http://purl.uniprot.org/uniprot/A0A2R9AH84 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/9597:RPL21 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJM6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/9597:LOXL2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNC1 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/9597:RHOT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BIP4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial Rho GTPase family.|||Membrane|||Mitochondrial GTPase involved in mitochondrial trafficking.|||Mitochondrion outer membrane http://togogenome.org/gene/9597:PPP2R2A ^@ http://purl.uniprot.org/uniprot/A0A2R9B314 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/9597:MRPL27 ^@ http://purl.uniprot.org/uniprot/A0A2R9BR84 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/9597:FUCA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BZA7 ^@ Function|||Similarity|||Subunit ^@ Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.|||Belongs to the glycosyl hydrolase 29 family.|||Homotetramer. http://togogenome.org/gene/9597:F2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C6W7 ^@ Caution|||Function|||Similarity ^@ Belongs to the peptidase S1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. http://togogenome.org/gene/9597:MINDY3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CE46 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM188 subfamily.|||Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. http://togogenome.org/gene/9597:CCR6 ^@ http://purl.uniprot.org/uniprot/A0A2R9B7I6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9597:CDH9 ^@ http://purl.uniprot.org/uniprot/A0A2R9AV11 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:MRPL10 ^@ http://purl.uniprot.org/uniprot/A0A2R9B000 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL10 family. http://togogenome.org/gene/9597:ATP5F1B ^@ http://purl.uniprot.org/uniprot/A0A2R9BG76 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/9597:AWAT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9597:UGT2B4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9597:TRAPPC6B ^@ http://purl.uniprot.org/uniprot/A0A2R9C0U9|||http://purl.uniprot.org/uniprot/A0A2R9C3Y6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||cis-Golgi network http://togogenome.org/gene/9597:SNX14 ^@ http://purl.uniprot.org/uniprot/A0A2R9BRD1|||http://purl.uniprot.org/uniprot/A0A2R9BUT4 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9597:RAB3C ^@ http://purl.uniprot.org/uniprot/A0A2R8ZB83 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/9597:CHIA ^@ http://purl.uniprot.org/uniprot/A0A2R8ZL98 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. http://togogenome.org/gene/9597:TMEM115 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJV2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:TBRG1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A871 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:GTPBP4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CCI7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.|||Involved in the biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/9597:HACL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CEC8 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/9597:GNPAT ^@ http://purl.uniprot.org/uniprot/A0A2R9CPT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GPAT/DAPAT family.|||Peroxisome membrane http://togogenome.org/gene/9597:PNPLA4 ^@ http://purl.uniprot.org/uniprot/A0A2R9C601 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:CDH11 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZND1 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:STAC ^@ http://purl.uniprot.org/uniprot/A0A2R9C0J1 ^@ Subcellular Location Annotation ^@ sarcolemma http://togogenome.org/gene/9597:LOC100995302 ^@ http://purl.uniprot.org/uniprot/A0A2R9BNY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/9597:DNASE2B ^@ http://purl.uniprot.org/uniprot/A0A2R9AF39 ^@ Similarity ^@ Belongs to the DNase II family. http://togogenome.org/gene/9597:FGFR4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BFK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:AP4B1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BMU2|||http://purl.uniprot.org/uniprot/A0A2R9BMW7 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/9597:PNN ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZ35 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pinin family.|||Found in a mRNA splicing-dependent exon junction complex (EJC). Found in a complex with SR proteins. Found in a mRNP complex with RNPS1. Component of the PSAP complex consisting of RNPS1, SAP18 and PNN. Interacts with PNISR, CTBP1, CTBP2, KRT8, KRT18, KRT19, PS1D/PNO40, PPIG, RNPS1, SFRS4 and SRRM2. Identified in the spliceosome C complex.|||Nucleus speckle|||desmosome http://togogenome.org/gene/9597:SCGB2A2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BRF9 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9597:ORC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BD96 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC1 family.|||Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with CDC6 and KAT7/HBO1. Interacts with LRWD1 predominantly during the G1 phase and with less affinity during mitosis, when phosphorylated.|||Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.|||Nucleus http://togogenome.org/gene/9597:LOC100976465 ^@ http://purl.uniprot.org/uniprot/P68872 ^@ Function|||Similarity|||Subunit|||Tissue Specificity ^@ Belongs to the globin family.|||Heterotetramer of two alpha chains and two beta chains in adult hemoglobin A (HbA).|||Involved in oxygen transport from the lung to the various peripheral tissues.|||Red blood cells. http://togogenome.org/gene/9597:NPR2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ADF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane http://togogenome.org/gene/9597:TMEM175 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6H9|||http://purl.uniprot.org/uniprot/A0A2R8Z6J0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM175 family.|||Membrane http://togogenome.org/gene/9597:ZNF234 ^@ http://purl.uniprot.org/uniprot/A0A2R9AG22 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:ZNF549 ^@ http://purl.uniprot.org/uniprot/A0A2R9BS06 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:RNF112 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1X0 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9597:FZD4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BZZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:ZKSCAN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BG48 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9597:HCN3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel HCN family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:BECN2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFZ4 ^@ Similarity ^@ Belongs to the beclin family. http://togogenome.org/gene/9597:LOC100992942 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLK2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:NDUFS5 ^@ http://purl.uniprot.org/uniprot/A0A2R9A979 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS5 subunit family.|||Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9597:TMEM70 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGM5 ^@ Similarity ^@ Belongs to the TMEM70 family. http://togogenome.org/gene/9597:HEXIM1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HEXIM family.|||Nucleus http://togogenome.org/gene/9597:SERPINB10 ^@ http://purl.uniprot.org/uniprot/A0A2R9CEW8 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9597:ASRGL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BKT4 ^@ Similarity|||Subunit ^@ Belongs to the Ntn-hydrolase family.|||Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer. http://togogenome.org/gene/9597:RNF8 ^@ http://purl.uniprot.org/uniprot/A0A2R9AN67 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ According to a well-established model, RNF8 initiate H2A 'Lys-63'-linked ubiquitination leading to recruitment of RNF168 to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.|||Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger.|||Belongs to the CHFR family.|||Belongs to the RNF8 family.|||Cytoplasm|||E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains. Promotes non-homologous end joining (NHEJ) by promoting the 'Lys-48'-linked ubiquitination and degradation the of KU80/XRCC5. Following DNA damage, mediates the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF168, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Following DNA damage, mediates the ubiquitination and degradation of POLD4/p12, a subunit of DNA polymerase delta. In the absence of POLD4, DNA polymerase delta complex exhibits higher proofreading activity. In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation. Involved in the activation of ATM by promoting histone H2B ubiquitination, which indirectly triggers histone H4 'Lys-16' acetylation (H4K16ac), establishing a chromatin environment that promotes efficient activation of ATM kinase. Required in the testis, where it plays a role in the replacement of histones during spermatogenesis. At uncapped telomeres, promotes the joining of deprotected chromosome ends by inducing H2A ubiquitination and TP53BP1 recruitment, suggesting that it may enhance cancer development by aggravating telomere-induced genome instability in case of telomeric crisis. Promotes the assembly of RAD51 at DNA DSBs in the absence of BRCA1 and TP53BP1 Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. May be required for proper exit from mitosis after spindle checkpoint activation and may regulate cytokinesis. May play a role in the regulation of RXRA-mediated transcriptional activity. Not involved in RXRA ubiquitination by UBE2E2.|||Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N. Interacts with RXRA. Interacts (via FHA domain) with phosphorylated HERC2 (via C-terminus). Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm.|||Midbody|||Nucleus|||The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and phosphorylated HERC2.|||telomere http://togogenome.org/gene/9597:RRAGB ^@ http://purl.uniprot.org/uniprot/A0A2R9B054|||http://purl.uniprot.org/uniprot/A0A2R9B1D3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/9597:AMIGO1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. AMIGO family.|||Membrane http://togogenome.org/gene/9597:SKA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B3G3 ^@ Similarity ^@ Belongs to the SKA1 family. http://togogenome.org/gene/9597:LOC100980458 ^@ http://purl.uniprot.org/uniprot/A0A2R9ALI7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS8 family. http://togogenome.org/gene/9597:HOMER1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AR35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Homer family.|||Cytoplasm|||Postsynaptic density|||Synapse http://togogenome.org/gene/9597:P2RY4 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6L4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:PLOD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B141 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9597:LOC100974278 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:AP3M1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLD4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. http://togogenome.org/gene/9597:LOC100988698 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9U2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. BCS1 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9597:AOC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CKS0 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the copper/topaquinone oxidase family.|||Contains 1 topaquinone per subunit.|||Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. http://togogenome.org/gene/9597:ZC3H12A ^@ http://purl.uniprot.org/uniprot/A0A2R9CE60 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/9597:CIT ^@ http://purl.uniprot.org/uniprot/A0A2R9BDB7|||http://purl.uniprot.org/uniprot/A0A2R9BHA6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.|||Cytoplasm|||Plays a role in cytokinesis. Displays serine/threonine protein kinase activity. http://togogenome.org/gene/9597:XIAP ^@ http://purl.uniprot.org/uniprot/A0A2R9A858 ^@ Similarity ^@ Belongs to the IAP family. http://togogenome.org/gene/9597:FMNL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BRD6 ^@ Similarity ^@ Belongs to the formin homology family. http://togogenome.org/gene/9597:LPIN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ARS1 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/9597:HASPIN ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEN4 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/9597:POLR2H ^@ http://purl.uniprot.org/uniprot/A0A2R9BD68 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RPB8 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. http://togogenome.org/gene/9597:C5AR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZT73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:SMIM18 ^@ http://purl.uniprot.org/uniprot/A0A2R9ARL7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:TMC5 ^@ http://purl.uniprot.org/uniprot/A0A2R9B896 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMC family.|||Membrane http://togogenome.org/gene/9597:IGF2BP3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZ93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM IMP/VICKZ family.|||P-body|||Stress granule http://togogenome.org/gene/9597:FAM135B ^@ http://purl.uniprot.org/uniprot/A0A2R9C4Q5 ^@ Similarity ^@ Belongs to the FAM135 family. http://togogenome.org/gene/9597:PGAP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CF12|||http://purl.uniprot.org/uniprot/A0A2R9CF49 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PGAP2 family.|||Interacts with PGAP2IP.|||Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface.|||Membrane http://togogenome.org/gene/9597:LOC100968816 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCS6 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:GRHL3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZ59 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:DCP1A ^@ http://purl.uniprot.org/uniprot/A0A2R9CJ06|||http://purl.uniprot.org/uniprot/A0A2R9CQK4 ^@ Similarity ^@ Belongs to the DCP1 family. http://togogenome.org/gene/9597:TAC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AR82|||http://purl.uniprot.org/uniprot/A0A2R9AVR6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tachykinin family.|||Secreted|||Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. http://togogenome.org/gene/9597:KATNA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDG2 ^@ Activity Regulation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.|||Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.|||Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.|||Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.|||Cytoplasm|||Midbody|||Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.|||The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.|||Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.|||centrosome|||spindle|||spindle pole http://togogenome.org/gene/9597:LMOD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B0U2 ^@ Subcellular Location Annotation ^@ cytoskeleton|||sarcomere http://togogenome.org/gene/9597:LOC103783475 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPT0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9597:SENP6 ^@ http://purl.uniprot.org/uniprot/A0A2R9AAE8|||http://purl.uniprot.org/uniprot/A0A2R9AAF0 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/9597:DEDD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDV1 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9597:ANAPC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CGV8 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9597:UBE2S ^@ http://purl.uniprot.org/uniprot/A0A2R9C1F7 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9597:FBL ^@ http://purl.uniprot.org/uniprot/A0A2R9B441 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Fibrillarin family. http://togogenome.org/gene/9597:TOMM7 ^@ http://purl.uniprot.org/uniprot/A0A2R9C848 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom7 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9597:SLF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C158 ^@ Similarity ^@ Belongs to the FAM178 family. http://togogenome.org/gene/9597:PDP2 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6Q8 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9597:LOC100984072 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9597:RIDA ^@ http://purl.uniprot.org/uniprot/A0A2R9ABI3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RutC family.|||Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.|||Peroxisome http://togogenome.org/gene/9597:ARHGDIB ^@ http://purl.uniprot.org/uniprot/A0A2R9BGE4 ^@ Similarity ^@ Belongs to the Rho GDI family. http://togogenome.org/gene/9597:RHO ^@ http://purl.uniprot.org/uniprot/A0A2R9C4X0 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Contains one covalently linked retinal chromophore.|||Membrane http://togogenome.org/gene/9597:PMEL ^@ http://purl.uniprot.org/uniprot/A0A2R9B1T8 ^@ Similarity ^@ Belongs to the PMEL/NMB family. http://togogenome.org/gene/9597:MBOAT4 ^@ http://purl.uniprot.org/uniprot/A0A2R9APM1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:TCN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CFW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic cobalamin transport proteins family.|||Secreted http://togogenome.org/gene/9597:LOC129392969 ^@ http://purl.uniprot.org/uniprot/A0A2R9AYQ3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bZIP family.|||Cytoplasm|||Heterodimer.|||Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.|||Nucleus|||Phosphorylation at serine residues by MAPK14 enhances its transcriptional activation activity while phosphorylation at serine residues by CK2 inhibits its transcriptional activation activity.|||Ubiquitinated, leading to its degradation by the proteasome. http://togogenome.org/gene/9597:TLR6 ^@ http://purl.uniprot.org/uniprot/B3Y642 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:HIKESHI ^@ http://purl.uniprot.org/uniprot/A0A2R9BH75 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.|||Belongs to the OPI10 family.|||Cytoplasm|||Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.|||Nucleus|||cytosol http://togogenome.org/gene/9597:SLC66A3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUE9|||http://purl.uniprot.org/uniprot/A0A2R8ZX30 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:FDPS ^@ http://purl.uniprot.org/uniprot/A0A2R8Z608 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9597:RPL26 ^@ http://purl.uniprot.org/uniprot/A0A2R9CF39 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/9597:TMEM106B ^@ http://purl.uniprot.org/uniprot/A0A2R9ABQ4 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/9597:ELK4 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9R9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9597:ENTPD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CEE2 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9597:APOC4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CMV6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the apolipoprotein C4 family.|||May participate in lipoprotein metabolism.|||Secreted http://togogenome.org/gene/9597:HMBS ^@ http://purl.uniprot.org/uniprot/A0A2R8ZI12 ^@ Similarity ^@ Belongs to the HMBS family. http://togogenome.org/gene/9597:GPRC6A ^@ http://purl.uniprot.org/uniprot/A0A2R9APW7|||http://purl.uniprot.org/uniprot/A0A2R9APX1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:ZNF174 ^@ http://purl.uniprot.org/uniprot/A0A2R9ASF3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:MYOZ1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZU40 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/9597:FBP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CH13 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/9597:PLA2G5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJJ9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9597:NHSL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BDC9|||http://purl.uniprot.org/uniprot/A0A2R9BEK9 ^@ Similarity ^@ Belongs to the NHS family. http://togogenome.org/gene/9597:ZNF689 ^@ http://purl.uniprot.org/uniprot/A0A2R9ATC2 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:NXF3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NXF family.|||Cytoplasm http://togogenome.org/gene/9597:CAND2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEN6 ^@ Similarity ^@ Belongs to the CAND family. http://togogenome.org/gene/9597:YPEL5 ^@ http://purl.uniprot.org/uniprot/A0A2R9A6P4 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9597:CXCL13 ^@ http://purl.uniprot.org/uniprot/A0A2R9BK43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9597:RPL39L ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAE4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/9597:BPGM ^@ http://purl.uniprot.org/uniprot/A0A2R9A0W4 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/9597:RP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BVA9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.|||Belongs to the TBCC family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:POLR2F ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPY5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.|||Nucleus http://togogenome.org/gene/9597:AGPAT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTZ0 ^@ Domain|||Function|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/9597:KRBOX4 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABC9 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:PPT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CIZ8 ^@ Similarity ^@ Belongs to the palmitoyl-protein thioesterase family. http://togogenome.org/gene/9597:CFI ^@ http://purl.uniprot.org/uniprot/A0A2R9BVP8|||http://purl.uniprot.org/uniprot/A0A2R9BVQ4|||http://purl.uniprot.org/uniprot/A0A2R9C4V3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:RGS3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AX77|||http://purl.uniprot.org/uniprot/A0A2R9AX90 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:NASP ^@ http://purl.uniprot.org/uniprot/A0A2R9AQM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NASP family.|||Nucleus http://togogenome.org/gene/9597:CRYBA2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZH79 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9597:KAT2A ^@ http://purl.uniprot.org/uniprot/A0A2R9C6Z6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. GCN5 subfamily.|||Nucleus|||centrosome http://togogenome.org/gene/9597:LOC100972759 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZD62 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:LOC100983779 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQV3 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:LOC100975117 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHH7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9597:FCF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CBA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP23/FCF1 family. FCF1 subfamily.|||nucleolus http://togogenome.org/gene/9597:ZNF606 ^@ http://purl.uniprot.org/uniprot/A0A2R9B9N8 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:MRPS21 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9I8 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/9597:TAS1R1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AFU2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:LDHA ^@ http://purl.uniprot.org/uniprot/A0A2R9CIK4 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/9597:DLD ^@ http://purl.uniprot.org/uniprot/A0A2R9AX27 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond.|||acrosome|||flagellum http://togogenome.org/gene/9597:GOT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CFL4 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/9597:ARID3C ^@ http://purl.uniprot.org/uniprot/A0A2R9BT85 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Homodimer.|||Nucleus|||Transcription factor. http://togogenome.org/gene/9597:EPS8 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSG7 ^@ Similarity ^@ Belongs to the EPS8 family. http://togogenome.org/gene/9597:YPEL3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AFN5 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9597:LOC100978707 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZET0 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:ZNF225 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTQ5 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:TRMT11 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABD1 ^@ Function|||Subunit ^@ Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.|||Interacts with TRMT112. http://togogenome.org/gene/9597:RARA ^@ http://purl.uniprot.org/uniprot/A0A2R9CKZ4|||http://purl.uniprot.org/uniprot/A0A2R9CL03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9597:LOC100975092 ^@ http://purl.uniprot.org/uniprot/A0A2R9C257 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.|||Belongs to the universal ribosomal protein uS2 family.|||Cell membrane|||Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.|||Cytoplasm|||Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.|||Nucleus|||Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.|||This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. http://togogenome.org/gene/9597:KRT32 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEN7 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9597:SENP5 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5J3|||http://purl.uniprot.org/uniprot/A0A2R9C5X0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C48 family.|||nucleolus http://togogenome.org/gene/9597:TMEM214 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCE7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TMEM214 family.|||Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.|||Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:DLST ^@ http://purl.uniprot.org/uniprot/A0A2R9AG39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Mitochondrion matrix http://togogenome.org/gene/9597:DAD1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZR60 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DAD/OST2 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/9597:FERMT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B007|||http://purl.uniprot.org/uniprot/A0A2R9B1Z3 ^@ Similarity ^@ Belongs to the kindlin family. http://togogenome.org/gene/9597:LOC100982084 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z858 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:PIK3IP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A0C3|||http://purl.uniprot.org/uniprot/A0A2R9A4N9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:BMT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ALI9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the BMT2 family.|||Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.|||S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/9597:LSM2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AS13 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||Nucleus http://togogenome.org/gene/9597:TMEM205 ^@ http://purl.uniprot.org/uniprot/A0A2R9BS18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM205 family.|||Membrane http://togogenome.org/gene/9597:EIPR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat EIPR1 family.|||trans-Golgi network http://togogenome.org/gene/9597:AKR1D1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CM81 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9597:PIGF ^@ http://purl.uniprot.org/uniprot/A0A2R9CCW6|||http://purl.uniprot.org/uniprot/A0A2R9CD35 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:MDH1B ^@ http://purl.uniprot.org/uniprot/A0A2R9AHF3 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. MDH type 2 family. http://togogenome.org/gene/9597:PDE6G ^@ http://purl.uniprot.org/uniprot/A0A2R9A364 ^@ Function|||Similarity ^@ Belongs to the rod/cone cGMP-PDE gamma subunit family.|||Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. http://togogenome.org/gene/9597:CALCB ^@ http://purl.uniprot.org/uniprot/A0A2R9BXK8 ^@ Similarity ^@ Belongs to the calcitonin family. http://togogenome.org/gene/9597:DDX4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AVW3|||http://purl.uniprot.org/uniprot/A0A2R9AW64 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9597:UCP2 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z8W5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9597:MMAA ^@ http://purl.uniprot.org/uniprot/A0A2R9AIX0 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. http://togogenome.org/gene/9597:CHRNB3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BDF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9597:SLC5A12 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZA67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:KCNG4 ^@ http://purl.uniprot.org/uniprot/A0A2R9C6G9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:ASF1A ^@ http://purl.uniprot.org/uniprot/A0A2R9BUF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/9597:HRH1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZS93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:HARS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BVQ3|||http://purl.uniprot.org/uniprot/A0A2R9BZ56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/9597:WARS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C6X6 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9597:CXCL12 ^@ http://purl.uniprot.org/uniprot/A0A2R9C2C3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9597:RPS17 ^@ http://purl.uniprot.org/uniprot/A0A2R9C0N6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/9597:VAMP4 ^@ http://purl.uniprot.org/uniprot/A0A2R9A3T0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9597:FAM98A ^@ http://purl.uniprot.org/uniprot/A0A2R9BLM0 ^@ Similarity ^@ Belongs to the FAM98 family. http://togogenome.org/gene/9597:STAT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C943 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:LOC103782837 ^@ http://purl.uniprot.org/uniprot/A0A2R9CC67 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9597:DLK2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUJ4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:TJP3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CBY6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9597:EDEM2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B6J8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9597:GABRG2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CM58|||http://purl.uniprot.org/uniprot/A0A2R9CM76 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9597:LOC100973313 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZP55 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:BTG2 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9Z8 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9597:CARMIL3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BAR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CARMIL family.|||Cytoplasm http://togogenome.org/gene/9597:MST1R ^@ http://purl.uniprot.org/uniprot/A0A2R9AIE6|||http://purl.uniprot.org/uniprot/A0A2R9AM93 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:ABCA12 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTD5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:HSF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B097|||http://purl.uniprot.org/uniprot/A0A2R9B0A1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/9597:IDH3A ^@ http://purl.uniprot.org/uniprot/A0A2R9C4H6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.|||Mitochondrion http://togogenome.org/gene/9597:B9D1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVX6 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/9597:EIF3I ^@ http://purl.uniprot.org/uniprot/A0A2R9ADB9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit I family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm|||Phosphorylated by TGF-beta type II receptor. http://togogenome.org/gene/9597:HSDL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C0E3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9597:RNASE4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AR09 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9597:PLA2G12A ^@ http://purl.uniprot.org/uniprot/A0A2R9A9H1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Secreted http://togogenome.org/gene/9597:AP1G1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AGR9 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/9597:ADCK1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CLS1|||http://purl.uniprot.org/uniprot/A0A2R9CT82 ^@ Similarity ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family. http://togogenome.org/gene/9597:DGKB ^@ http://purl.uniprot.org/uniprot/A0A2R9BCL3|||http://purl.uniprot.org/uniprot/A0A2R9BEZ0 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/9597:LAMA4 ^@ http://purl.uniprot.org/uniprot/A0A2R9C435 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/9597:MED6 ^@ http://purl.uniprot.org/uniprot/A0A2R9CA51|||http://purl.uniprot.org/uniprot/A0A2R9CAC7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 6 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9597:C5H5orf24 ^@ http://purl.uniprot.org/uniprot/A0A2R9CPD9 ^@ Similarity ^@ Belongs to the UPF0461 family. http://togogenome.org/gene/9597:KDR ^@ http://purl.uniprot.org/uniprot/A0A2R9CED2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:ENO3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C630 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/9597:PTAFR ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQA4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with ARRB1.|||Membrane|||Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9597:RAP1GDS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AA08|||http://purl.uniprot.org/uniprot/A0A2R9AA23 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum|||Mitochondrion http://togogenome.org/gene/9597:EIF6 ^@ http://purl.uniprot.org/uniprot/A0A2R9ADA3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-6 family.|||Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.|||Cytoplasm|||Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).|||Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.|||nucleolus http://togogenome.org/gene/9597:LOC100982199 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZN48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase VIIb family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9597:DUSP7 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJY9 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9597:RO60 ^@ http://purl.uniprot.org/uniprot/A0A2R9CN56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ro 60 kDa family.|||Cytoplasm http://togogenome.org/gene/9597:NNT ^@ http://purl.uniprot.org/uniprot/A0A2R8ZD06 ^@ Similarity ^@ In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/9597:UNC13B ^@ http://purl.uniprot.org/uniprot/A0A2R9BH08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-13 family.|||Cytoplasm|||Membrane http://togogenome.org/gene/9597:CSE1L ^@ http://purl.uniprot.org/uniprot/A0A2R9BNT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPO2/CSE1 family.|||Cytoplasm http://togogenome.org/gene/9597:IL1RAP ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEL5 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9597:PSMA8 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZX05 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9597:LOC100976704 ^@ http://purl.uniprot.org/uniprot/A0A2R9BLT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9597:CRY2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AVA7 ^@ Cofactor|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/9597:DNTT ^@ http://purl.uniprot.org/uniprot/A0A2R9C288 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||Nucleus|||Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. http://togogenome.org/gene/9597:SLC24A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CF90|||http://purl.uniprot.org/uniprot/A0A2R9CFC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/9597:DNTTIP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVI0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:LOC100980195 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJC7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9597:FAM3C ^@ http://purl.uniprot.org/uniprot/A0A2R9BJ58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/9597:HSPA4 ^@ http://purl.uniprot.org/uniprot/A0A2R9C712 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 70 family.|||Cytoplasm|||Interacts with TJP1/ZO-1. http://togogenome.org/gene/9597:KRT76 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9C9 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9597:RRP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A8G5 ^@ Similarity ^@ Belongs to the RRP1 family. http://togogenome.org/gene/9597:GPR87 ^@ http://purl.uniprot.org/uniprot/A0A2R9BZI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:E2F8 ^@ http://purl.uniprot.org/uniprot/A0A2R9B864 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9597:ZFYVE27 ^@ http://purl.uniprot.org/uniprot/A0A2R9A4L5|||http://purl.uniprot.org/uniprot/A0A2R9A5R8 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Endosome membrane|||Membrane|||Recycling endosome membrane|||growth cone membrane http://togogenome.org/gene/9597:COPB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BT66 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ COPI-coated vesicle membrane|||Cytoplasm|||Endoplasmic reticulum-Golgi intermediate compartment|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/9597:NOP14 ^@ http://purl.uniprot.org/uniprot/A0A2R9BLU8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP14 family.|||Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.|||nucleolus http://togogenome.org/gene/9597:TGFB1I1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BBV8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the paxillin family.|||Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways.|||Nucleus matrix|||The LD (leucine and aspartate-rich) motif 3 mediates interaction with GIT1 and functions as a nuclear export signal.|||cytoskeleton|||focal adhesion http://togogenome.org/gene/9597:OXA1L ^@ http://purl.uniprot.org/uniprot/A0A2R9AX51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OXA1/ALB3/YidC family.|||Membrane http://togogenome.org/gene/9597:LRRFIP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSQ3 ^@ Similarity ^@ Belongs to the LRRFIP family. http://togogenome.org/gene/9597:ETFRF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BVR7 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9597:MYO1B ^@ http://purl.uniprot.org/uniprot/A0A2R9BYI9|||http://purl.uniprot.org/uniprot/A0A2R9C4U5|||http://purl.uniprot.org/uniprot/A0A2R9C4V0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9597:PPP4R3C ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAF7 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/9597:GPR180 ^@ http://purl.uniprot.org/uniprot/A0A2R9C6S9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:ENY2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CM41 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ENY2 family.|||Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.|||Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.|||nucleoplasm http://togogenome.org/gene/9597:NR0B1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNT6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR0 subfamily.|||Cytoplasm|||Nucleus|||Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency. http://togogenome.org/gene/9597:CPT1B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZN01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the carnitine/choline acetyltransferase family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9597:ADAM15 ^@ http://purl.uniprot.org/uniprot/A0A2R9BLW5|||http://purl.uniprot.org/uniprot/A0A2R9BLW9|||http://purl.uniprot.org/uniprot/A0A2R9BM08|||http://purl.uniprot.org/uniprot/A0A2R9BMT1|||http://purl.uniprot.org/uniprot/A0A2R9BVZ8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:SCAMP5 ^@ http://purl.uniprot.org/uniprot/A0A2R9CE85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/9597:HOXC6 ^@ http://purl.uniprot.org/uniprot/A0A2R9BDQ6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:ENPP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJU3|||http://purl.uniprot.org/uniprot/A0A2R9AJU7|||http://purl.uniprot.org/uniprot/A0A2R9APG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.|||Secreted http://togogenome.org/gene/9597:MRPS7 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZN53 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS7 family. http://togogenome.org/gene/9597:LOC100976375 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVA2 ^@ Similarity ^@ Belongs to the PRAME family. http://togogenome.org/gene/9597:PTMA ^@ http://purl.uniprot.org/uniprot/A0A2R9CFU6 ^@ Similarity ^@ Belongs to the pro/parathymosin family. http://togogenome.org/gene/9597:LOC100977815 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCK4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:EGR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A849 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Nucleus|||Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. http://togogenome.org/gene/9597:LOC100990846 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNX0 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:SNRPD3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C1Q4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.|||cytosol http://togogenome.org/gene/9597:KCNE1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIR2 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the potassium channel KCNE family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:CACNG2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZR06 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane|||Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. http://togogenome.org/gene/9597:CIAPIN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C840 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the anamorsin family.|||Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion intermembrane space|||Monomer. Interacts with NDOR1. Interacts with CHCHD4.|||Nucleus|||The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.|||The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.|||The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space. http://togogenome.org/gene/9597:LOC100995405 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZF24 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:MVK ^@ http://purl.uniprot.org/uniprot/A0A2R9CMF3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Mevalonate kinase subfamily.|||Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.|||Cytoplasm http://togogenome.org/gene/9597:ESRRG ^@ http://purl.uniprot.org/uniprot/A0A2R9B322 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/9597:ELOA ^@ http://purl.uniprot.org/uniprot/A0A2R8Z8S5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:CRCP ^@ http://purl.uniprot.org/uniprot/A0A2R9AB98|||http://purl.uniprot.org/uniprot/A0A2R9ACB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC9 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/9597:ZNF586 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUY7|||http://purl.uniprot.org/uniprot/A0A2R8ZW53 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9597:EYA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSL8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/9597:EFTUD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AB34 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:HMGN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AT03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/9597:SLC1A3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQ15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9597:EIF2D ^@ http://purl.uniprot.org/uniprot/A0A2R9AWK3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF2D family.|||Cytoplasm|||Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. http://togogenome.org/gene/9597:LOC100991849 ^@ http://purl.uniprot.org/uniprot/A0A2R9BWP9 ^@ Similarity|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/9597:TSPAN9 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9597:OGFOD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AE79 ^@ Similarity ^@ Belongs to the TPA1 family. http://togogenome.org/gene/9597:CANX ^@ http://purl.uniprot.org/uniprot/A0A2R9AWV7 ^@ Similarity ^@ Belongs to the calreticulin family. http://togogenome.org/gene/9597:PPP2R5A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLU4 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9597:CTSO ^@ http://purl.uniprot.org/uniprot/A0A2R9CA02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9597:RAB21 ^@ http://purl.uniprot.org/uniprot/A0A2R9CLV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cleavage furrow|||Early endosome membrane|||Endoplasmic reticulum membrane|||Endosome membrane|||trans-Golgi network http://togogenome.org/gene/9597:COPS7A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKI9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:MASP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BDE3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:CBLB ^@ http://purl.uniprot.org/uniprot/A0A2R9AMN4 ^@ Domain|||Function ^@ E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.|||The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain. http://togogenome.org/gene/9597:HS6ST2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AKB0|||http://purl.uniprot.org/uniprot/A0A2R9AL13 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.|||Belongs to the sulfotransferase 6 family.|||Membrane http://togogenome.org/gene/9597:TPMT ^@ http://purl.uniprot.org/uniprot/A0A2R9A781 ^@ Similarity|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.|||Monomer. http://togogenome.org/gene/9597:ODF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ARA0|||http://purl.uniprot.org/uniprot/A0A2R9AVZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ODF2 family.|||centrosome http://togogenome.org/gene/9597:RBCK1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ARJ5 ^@ Similarity ^@ Belongs to the RBR family. http://togogenome.org/gene/9597:BRCA1 ^@ http://purl.uniprot.org/uniprot/A0A075VQZ2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Chromosome|||Cytoplasm|||E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Required for FANCD2 targeting to sites of DNA damage. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator.|||Heterodimer with BARD1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the MRE11-RAD50-NBN protein (MRN) complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Interacts (via the BRCT domains) with ABRAXAS1 (phosphorylated form); this is important for recruitment to sites of DNA damage. Can form a heterotetramer with two molecules of ABRAXAS1 (phosphorylated form). Component of the BRCA1-RBBP8 complex. Interacts (via the BRCT domains) with RBBP8 ('Ser-327' phosphorylated form); the interaction ubiquitinates RBBP8, regulates CHEK1 activation, and involves RBBP8 in BRCA1-dependent G2/M checkpoint control on DNA damage. Associates with RNA polymerase II holoenzyme. Interacts with SMC1A, NELFB, DCLRE1C, CLSPN. CHEK1, CHEK2, BAP1, BRCC3, UBXN1 and PCLAF. Interacts (via BRCT domains) with BRIP1 (phosphorylated form). Interacts with FANCD2 (ubiquitinated form). Interacts with H2AX (phosphorylated on 'Ser-140'). Interacts (via the BRCT domains) with ACACA (phosphorylated form); the interaction prevents dephosphorylation of ACACA. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Interacts directly with PALB2; the interaction is essential for its function in HRR. Interacts directly with BRCA2; the interaction occurs only in the presence of PALB2 which serves as the bridging protein. Interacts (via the BRCT domains) with LMO4; the interaction represses the transcriptional activity of BRCA1. Interacts (via the BRCT domains) with CCAR2 (via N-terminus); the interaction represses the transcriptional activator activity of BRCA1. Interacts with EXD2. Interacts (via C-terminus) with DHX9; this interaction is direct and links BRCA1 to the RNA polymerase II holoenzyme.|||Nucleus http://togogenome.org/gene/9597:ICAM1 ^@ http://purl.uniprot.org/uniprot/Q5NKV4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the immunoglobulin superfamily. ICAM family.|||Homodimer. Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Interacts (on T cell side) with CD81, CD247 and CD9 at immunological synapses between antigen-presenting cells and T cells.|||ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity).|||Membrane|||Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis. http://togogenome.org/gene/9597:CHMP2B ^@ http://purl.uniprot.org/uniprot/A0A2R9ARV3 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9597:EGFL7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BNP8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:ZNF274 ^@ http://purl.uniprot.org/uniprot/A0A2R9AMB7 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9597:PTGFR ^@ http://purl.uniprot.org/uniprot/A0A2R9B3G5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:RLN2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZRM0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.|||Secreted http://togogenome.org/gene/9597:LSS ^@ http://purl.uniprot.org/uniprot/A0A2R9B2H2 ^@ Similarity ^@ Belongs to the terpene cyclase/mutase family. http://togogenome.org/gene/9597:SHMT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AVY3 ^@ Function|||Similarity ^@ Belongs to the SHMT family.|||Interconversion of serine and glycine. http://togogenome.org/gene/9597:SUPT5H ^@ http://purl.uniprot.org/uniprot/A0A2R9C9U3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT5 family.|||Nucleus http://togogenome.org/gene/9597:AGPAT4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CBN8 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9597:CSMD3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C8Y9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:WDR76 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMQ6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the WD repeat DDB2/WDR76 family.|||Interacts with CUL4A and/or CUL4B.|||Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. http://togogenome.org/gene/9597:FAAH ^@ http://purl.uniprot.org/uniprot/A0A2R9AN18 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/9597:LOC100992664 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPV1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:SPX ^@ http://purl.uniprot.org/uniprot/A0A2R9A851 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the spexin family.|||Secreted http://togogenome.org/gene/9597:BICD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C2W7|||http://purl.uniprot.org/uniprot/A0A2R9C2W9|||http://purl.uniprot.org/uniprot/A0A2R9C2X1 ^@ Similarity ^@ Belongs to the BicD family. http://togogenome.org/gene/9597:PTPN6 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVQ8|||http://purl.uniprot.org/uniprot/A0A2R8ZWV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.|||Cytoplasm http://togogenome.org/gene/9597:IL12A ^@ http://purl.uniprot.org/uniprot/A0A2R9BQY2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-6 superfamily.|||Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.|||Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes. As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine. Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites.|||Secreted http://togogenome.org/gene/9597:BARHL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B1X9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:NXF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C974 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NXF family.|||Cytoplasm|||nucleoplasm http://togogenome.org/gene/9597:NEK7 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9G9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:YAF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZB3|||http://purl.uniprot.org/uniprot/A0A2R9B1A0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:LOC100974797 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDX8 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9597:GALNT15 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5X3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:PGAP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTW7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI inositol-deacylase family.|||Endoplasmic reticulum membrane|||Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.|||Membrane http://togogenome.org/gene/9597:ZDHHC5 ^@ http://purl.uniprot.org/uniprot/A0A2R9BMP4 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9597:BTG3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CEI1 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9597:KPNA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BX67 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9597:SGSM2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BQQ1|||http://purl.uniprot.org/uniprot/A0A2R9BZT2 ^@ Similarity ^@ Belongs to the RUTBC family. http://togogenome.org/gene/9597:LOC100988794 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEZ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:SMARCA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B0H8|||http://purl.uniprot.org/uniprot/A0A2R9B6Z0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.|||Nucleus http://togogenome.org/gene/9597:LEF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CF20|||http://purl.uniprot.org/uniprot/A0A2R9CPR7|||http://purl.uniprot.org/uniprot/A0A2R9CPR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCF/LEF family.|||Nucleus http://togogenome.org/gene/9597:LDOC1 ^@ http://purl.uniprot.org/uniprot/Q6SEH4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LDOC1 family.|||Interacts with NOD2.|||May have an important role in the development and/or progression of some cancers.|||Nucleus http://togogenome.org/gene/9597:CFAP157 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUB0 ^@ Similarity ^@ Belongs to the CFAP157 family. http://togogenome.org/gene/9597:POLR2M ^@ http://purl.uniprot.org/uniprot/A0A2R8Z958 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRINL1 family.|||Nucleus http://togogenome.org/gene/9597:ZDHHC13 ^@ http://purl.uniprot.org/uniprot/A0A2R9CM25 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9597:PPP4C ^@ http://purl.uniprot.org/uniprot/A0A2R9AX24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/9597:PPIA ^@ http://purl.uniprot.org/uniprot/A0A286QUP5|||http://purl.uniprot.org/uniprot/Q0ZQL2 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization (By similarity). PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition (By similarity). Acetylation at Lys-125 favors the interaction with TARDBP (By similarity).|||Belongs to the cyclophilin-type PPIase family.|||Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.|||Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.|||Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity).|||Cytoplasm|||Interacts with protein phosphatase PPP3CA/calcineurin A (By similarity). Interacts with isoform 2 of BSG/CD147 (By similarity). Interacts with FOXO1; the interaction promotes FOXO1 dephosphorylation, nuclear accumulation and transcriptional activity (By similarity). Interacts with integrin ITGA2B:ITGB3; the interaction is ROS and peptidyl-prolyl cis-trans isomerase (PPIase) activity-dependent and is increased in the presence of thrombin (By similarity). Interacts with MAP3K5 (By similarity). Interacts with TARDBP; the interaction is dependent on the RNA-binding activity of TARDBP and the PPIase activity of PPIA/CYPA and the acetylation of PPIA/CYPA at Lys-125 favors the interaction (By similarity). Interacts with HNRNPA1, HNRNPA2B1, HNRNPC, RBMX, HNRNPK and HNRNPM (By similarity).|||Nucleus|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.|||Secreted http://togogenome.org/gene/9597:EWSR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ARH0|||http://purl.uniprot.org/uniprot/A0A2R9AXK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TET family.|||Nucleus http://togogenome.org/gene/9597:VEZT ^@ http://purl.uniprot.org/uniprot/A0A2R9ASA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vezatin family.|||Cell membrane|||Membrane|||Nucleus|||adherens junction http://togogenome.org/gene/9597:MED9 ^@ http://purl.uniprot.org/uniprot/A0A2R9CSE1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 9 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9597:LOC100979729 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBG7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:FOXP2 ^@ http://purl.uniprot.org/uniprot/Q8HZ00 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1 (By similarity). Interacts with FOXP1 (By similarity). Interacts with TBR1 (By similarity). Interacts with ZMYM2 (By similarity).|||Nucleus|||The leucine-zipper is required for dimerization and transcriptional repression.|||Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels (By similarity). http://togogenome.org/gene/9597:ARPIN ^@ http://purl.uniprot.org/uniprot/A0A2R9C3M6 ^@ Similarity ^@ Belongs to the Arpin family. http://togogenome.org/gene/9597:ADK ^@ http://purl.uniprot.org/uniprot/A0A2R9ARG8|||http://purl.uniprot.org/uniprot/A0A2R9AY42 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.|||Belongs to the carbohydrate kinase PfkB family.|||Binds 3 Mg(2+) ions per subunit.|||Monomer.|||Nucleus http://togogenome.org/gene/9597:MLF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B1C6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MLF family.|||Cytoplasm http://togogenome.org/gene/9597:CCN4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CCT8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9597:KRT82 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZX5 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9597:GAL3ST1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B778 ^@ Similarity ^@ Belongs to the galactose-3-O-sulfotransferase family. http://togogenome.org/gene/9597:DLX3 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7N5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus http://togogenome.org/gene/9597:BAZ2A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBN1|||http://purl.uniprot.org/uniprot/A0A2R8ZBP4 ^@ Similarity ^@ Belongs to the WAL family. http://togogenome.org/gene/9597:LCMT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A988|||http://purl.uniprot.org/uniprot/A0A2R9AD96 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. LCMT family.|||Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. http://togogenome.org/gene/9597:CMTM6 ^@ http://purl.uniprot.org/uniprot/A0A2R9B108 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:RARB ^@ http://purl.uniprot.org/uniprot/A0A2R9BQB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9597:SLC29A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AV25|||http://purl.uniprot.org/uniprot/A0A2R9B164 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Basolateral cell membrane|||Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9597:LOC100982707 ^@ http://purl.uniprot.org/uniprot/A0A2R9AR78 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:KIAA1191 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMV5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P33MONOX family.|||Cytoplasm|||Interacts with NELFB, NOL12 and PRNP.|||Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth. http://togogenome.org/gene/9597:GJB6 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJN9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9597:POLR3K ^@ http://purl.uniprot.org/uniprot/A0A2R9BVX3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/9597:PIERCE1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDG2 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.|||cilium axoneme http://togogenome.org/gene/9597:ADGRG3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJ79 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:CAMSAP2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZV42|||http://purl.uniprot.org/uniprot/A0A2R8ZWB3 ^@ Domain|||Similarity ^@ Belongs to the CAMSAP1 family.|||The CKK domain binds microtubules. http://togogenome.org/gene/9597:CASQ1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AKL1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calsequestrin family.|||Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.|||Sarcoplasmic reticulum lumen http://togogenome.org/gene/9597:CDC14A ^@ http://purl.uniprot.org/uniprot/A0A2R9A7W1 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily. http://togogenome.org/gene/9597:PGBD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BPD9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:CKMT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C757 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/9597:PCK2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AWJ1 ^@ Similarity|||Subunit ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.|||Monomer. http://togogenome.org/gene/9597:FXYD7 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYP9 ^@ Similarity ^@ Belongs to the FXYD family. http://togogenome.org/gene/9597:NCLN ^@ http://purl.uniprot.org/uniprot/A0A2R9CIF4 ^@ Function|||Similarity ^@ Belongs to the nicastrin family.|||May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. http://togogenome.org/gene/9597:ELF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9597:CFL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C8K4 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. http://togogenome.org/gene/9597:SPG7 ^@ http://purl.uniprot.org/uniprot/A0A2R9AEG9 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/9597:LOC100994379 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHK0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:ADCY9 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJ01 ^@ Similarity ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. http://togogenome.org/gene/9597:DARS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BVT7 ^@ Function|||Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. http://togogenome.org/gene/9597:OAT ^@ http://purl.uniprot.org/uniprot/A0A2R9B3M7 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9597:FADS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CGV6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:MTMR2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CCM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/9597:PLPPR4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZRA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9597:SEC23A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZK3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9597:SPESP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C237 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPESP1 family.|||Involved in fertilization ability of sperm.|||acrosome http://togogenome.org/gene/9597:SCUBE3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CN24 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9597:CAMK2N1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CHD7 ^@ Similarity ^@ Belongs to the CAMK2N family. http://togogenome.org/gene/9597:MRPL22 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZV58 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/9597:CRPPA ^@ http://purl.uniprot.org/uniprot/A0A2R9AYY5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.|||Homodimer.|||cytosol http://togogenome.org/gene/9597:FAXC ^@ http://purl.uniprot.org/uniprot/A0A2R9C329 ^@ Similarity ^@ Belongs to the FAX family. http://togogenome.org/gene/9597:MSL3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BVN3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:HDAC10 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5A7|||http://purl.uniprot.org/uniprot/A0A2R9C5B5|||http://purl.uniprot.org/uniprot/A0A2R9C5C1 ^@ Similarity ^@ Belongs to the histone deacetylase family. HD type 2 subfamily. http://togogenome.org/gene/9597:ZNF879 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACJ3 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:TMEM176B ^@ http://purl.uniprot.org/uniprot/A0A2R9B455 ^@ Similarity ^@ Belongs to the TMEM176 family. http://togogenome.org/gene/9597:ITGAX ^@ http://purl.uniprot.org/uniprot/A0A2R9CEB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9597:LOC100989385 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBG5 ^@ Similarity ^@ Belongs to the CTAG/PCC1 family. http://togogenome.org/gene/9597:CDK7 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZV4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. http://togogenome.org/gene/9597:OVOL1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAZ8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:KCNJ8 ^@ http://purl.uniprot.org/uniprot/A0A2R9BZP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9597:LOC100984974 ^@ http://purl.uniprot.org/uniprot/A0A2R9BHM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCRH/QCR6 family.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:BTBD10 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGH8|||http://purl.uniprot.org/uniprot/A0A2R8ZMT5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:CDH6 ^@ http://purl.uniprot.org/uniprot/A0A2R9AUM4 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:LOC100976643 ^@ http://purl.uniprot.org/uniprot/A0A2R9AM62 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:SLU7 ^@ http://purl.uniprot.org/uniprot/A0A2R9ATP1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the SLU7 family.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/9597:NDUFB9 ^@ http://purl.uniprot.org/uniprot/A0A2R9BV43 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I LYR family.|||Mammalian complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:RHBG ^@ http://purl.uniprot.org/uniprot/A0A2R9AUJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/9597:NAPB ^@ http://purl.uniprot.org/uniprot/A0A2R9CL04 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/9597:FBLN2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIS8|||http://purl.uniprot.org/uniprot/A0A2R8ZLT8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fibulin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9597:SLC13A4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BPY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/9597:PDCD5 ^@ http://purl.uniprot.org/uniprot/A0A2R9CB80|||http://purl.uniprot.org/uniprot/A0A2R9CDY4 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/9597:ATP10A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9597:MAN2A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BN84 ^@ Cofactor|||Similarity ^@ Belongs to the glycosyl hydrolase 38 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9597:NKIRAS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B1Q5 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. http://togogenome.org/gene/9597:CDK10 ^@ http://purl.uniprot.org/uniprot/A0A2R9A3I8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:CD40 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4Y2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:KCNMB4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BLF6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KCNMB (TC 8.A.14.1) family.|||Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.|||Membrane|||N-glycosylated.|||Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. http://togogenome.org/gene/9597:EHHADH ^@ http://purl.uniprot.org/uniprot/A0A2R9C5M2|||http://purl.uniprot.org/uniprot/A0A2R9C5M5 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9597:PTPN12 ^@ http://purl.uniprot.org/uniprot/A0A2R9A8Z3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.|||Cytoplasm|||Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. http://togogenome.org/gene/9597:PLXNA3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BG96 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the plexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:FMO3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B212 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.|||Membrane|||Microsome membrane http://togogenome.org/gene/9597:GLMP ^@ http://purl.uniprot.org/uniprot/A0A2R9A1F5|||http://purl.uniprot.org/uniprot/A0A2R9A6V4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GLMP family.|||Interacts (via lumenal domain) with lysosomal protein MFSD1; the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stability and lysosomal localization of MFSD1.|||Lysosome membrane|||Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization. http://togogenome.org/gene/9597:SPACA4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJ98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPACA4/bouncer family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:SERPIND1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4A0 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9597:ARL14 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGM7 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9597:ALLC ^@ http://purl.uniprot.org/uniprot/A0A2R9CJV7 ^@ Function|||Similarity ^@ Belongs to the allantoicase family.|||The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals. http://togogenome.org/gene/9597:SFT2D1 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6F8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.|||Membrane http://togogenome.org/gene/9597:HNRNPC ^@ http://purl.uniprot.org/uniprot/A0A2R9AWL7 ^@ Similarity ^@ Belongs to the RRM HNRPC family. RALY subfamily. http://togogenome.org/gene/9597:VAMP2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZRD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9597:KREMEN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CBG3|||http://purl.uniprot.org/uniprot/A0A2R9CJE4 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. http://togogenome.org/gene/9597:STAG2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTK7|||http://purl.uniprot.org/uniprot/A0A2R9BU86 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||centromere http://togogenome.org/gene/9597:RPS6KA4 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9L7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9597:PSMB9 ^@ http://purl.uniprot.org/uniprot/A0A2R9BXY1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:PTGER2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BKS0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9597:NOTCH4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AC37 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOTCH family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Nucleus http://togogenome.org/gene/9597:ATRX ^@ http://purl.uniprot.org/uniprot/A0A2R9CKN0|||http://purl.uniprot.org/uniprot/A0A2R9CKP8 ^@ Subcellular Location Annotation ^@ Nucleus|||telomere http://togogenome.org/gene/9597:LOC100987488 ^@ http://purl.uniprot.org/uniprot/A0A2R9CHP6 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9597:GRPEL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AM09 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GrpE family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion matrix http://togogenome.org/gene/9597:VPS37B ^@ http://purl.uniprot.org/uniprot/A0A2R9BHG2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9597:SERPINA11 ^@ http://purl.uniprot.org/uniprot/A0A2R9BAT4 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9597:EIF3G ^@ http://purl.uniprot.org/uniprot/A0A2R8ZXP0 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit G family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of FRAP1 and RAPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts (via C-terminus) with AIFM1 (via N-terminus).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Phosphorylated. Phosphorylation is enhanced upon serum stimulation.|||RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA.|||perinuclear region http://togogenome.org/gene/9597:RAD52 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJX7 ^@ Similarity ^@ Belongs to the RAD52 family. http://togogenome.org/gene/9597:LOC100990437 ^@ http://purl.uniprot.org/uniprot/A0A2R9BIH0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NADPH--cytochrome P450 reductase family.|||Binds 1 FAD per monomer.|||Binds 1 FMN per monomer.|||Endoplasmic reticulum membrane|||In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||In the N-terminal section; belongs to the flavodoxin family.|||This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. http://togogenome.org/gene/9597:YWHAE ^@ http://purl.uniprot.org/uniprot/A0A2R9AF76 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9597:PPIH ^@ http://purl.uniprot.org/uniprot/A0A2R9AZ52 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9597:CAMP ^@ http://purl.uniprot.org/uniprot/A0A2R9CDL0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cathelicidin family.|||Exhibits antimicrobial activity against E.coli and B.megaterium (in vitro).|||Secreted|||Vesicle http://togogenome.org/gene/9597:GORAB ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZP2 ^@ Similarity ^@ Belongs to the GORAB family. http://togogenome.org/gene/9597:ASF1B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/9597:GLS2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZ76 ^@ Similarity ^@ Belongs to the glutaminase family. http://togogenome.org/gene/9597:GSDMD ^@ http://purl.uniprot.org/uniprot/A0A2R9BZY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gasdermin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:TCEA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B8I3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family.|||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.|||Nucleus http://togogenome.org/gene/9597:C19H19orf53 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTN2 ^@ Function|||Similarity ^@ Belongs to the UPF0390 family.|||May have a potential role in hypercalcemia of malignancy. http://togogenome.org/gene/9597:LOC100984344 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZ99|||http://purl.uniprot.org/uniprot/A0A2R9B0M1|||http://purl.uniprot.org/uniprot/A0A2R9B3A9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C2 family.|||Calcium-regulated non-lysosomal thiol-protease.|||Cytoplasm|||Homodimer.|||nucleolus http://togogenome.org/gene/9597:PDHX ^@ http://purl.uniprot.org/uniprot/A0A2R9ACF8|||http://purl.uniprot.org/uniprot/A0A2R9AIF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Mitochondrion matrix http://togogenome.org/gene/9597:ALKBH7 ^@ http://purl.uniprot.org/uniprot/A0A2R9A4P4 ^@ Similarity ^@ Belongs to the alkB family. http://togogenome.org/gene/9597:IFNGR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AUN0 ^@ Similarity ^@ Belongs to the type II cytokine receptor family. http://togogenome.org/gene/9597:MPDU1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C0V2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MPDU1 (TC 2.A.43.3) family.|||Membrane|||Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors. http://togogenome.org/gene/9597:SLC6A15 ^@ http://purl.uniprot.org/uniprot/A0A2R9CFW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A15 subfamily.|||Membrane http://togogenome.org/gene/9597:ZEB2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPM1 ^@ Similarity ^@ Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family. http://togogenome.org/gene/9597:ADAMTS3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CC15 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9597:GPR156 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:NAPA ^@ http://purl.uniprot.org/uniprot/A0A2R9AUR4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/9597:PLA2G2D ^@ http://purl.uniprot.org/uniprot/A0A2R9AN17 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9597:TMTC3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CCB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/9597:SERPINB12 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZU00 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9597:TIMM50 ^@ http://purl.uniprot.org/uniprot/A0A2R9CGD7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM50 family.|||Component of the TIM23 complex.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:GATM ^@ http://purl.uniprot.org/uniprot/A0A2R9CTN1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the amidinotransferase family.|||Homodimer.|||Mitochondrion inner membrane|||Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives. Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain. http://togogenome.org/gene/9597:RFTN2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZX69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the raftlin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:SCPEP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CPC7 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/9597:ZNF615 ^@ http://purl.uniprot.org/uniprot/A0A2R9BD23 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:XK ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9597:BCOR ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUV0 ^@ Similarity ^@ Belongs to the BCOR family. http://togogenome.org/gene/9597:VEGFC ^@ http://purl.uniprot.org/uniprot/A0A2R9CHL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDGF/VEGF growth factor family.|||Secreted http://togogenome.org/gene/9597:TINAG ^@ http://purl.uniprot.org/uniprot/A0A2R9AH55 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/9597:RPS7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BWL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eS7 family.|||centrosome http://togogenome.org/gene/9597:NAAA ^@ http://purl.uniprot.org/uniprot/A0A2R9C7X5|||http://purl.uniprot.org/uniprot/A0A2R9CFJ2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acid ceramidase family.|||Heterodimer.|||Lysosome http://togogenome.org/gene/9597:ALDH3B1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9W4 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9597:UCP3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJ16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9597:MTMR7 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/9597:LOC100974064 ^@ http://purl.uniprot.org/uniprot/A0A2R9C3U6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing.|||cytosol http://togogenome.org/gene/9597:CMC4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AEY1 ^@ Similarity ^@ Belongs to the CMC4 family. http://togogenome.org/gene/9597:AMBN ^@ http://purl.uniprot.org/uniprot/A0A2R9CKL8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ameloblastin family.|||Involved in the mineralization and structural organization of enamel.|||extracellular matrix http://togogenome.org/gene/9597:LOC100970460 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9597:LAMTOR5 ^@ http://purl.uniprot.org/uniprot/A0A2R9CGM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR5 family.|||Lysosome http://togogenome.org/gene/9597:LOC100988476 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJC6 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:RGR ^@ http://purl.uniprot.org/uniprot/A0A2R9C9Y3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:CASC3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B9B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CASC3 family.|||Nucleus speckle|||dendrite|||perinuclear region http://togogenome.org/gene/9597:PRAF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CC95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/9597:SLC9A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CKJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9597:LOC100992836 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQ08 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:GAREM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AMT4 ^@ Similarity ^@ Belongs to the GAREM family. http://togogenome.org/gene/9597:LOC100986591 ^@ http://purl.uniprot.org/uniprot/A0A2R9CMD5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:ST6GALNAC4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9597:LOC100992118 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQM2 ^@ Similarity ^@ Belongs to the COX20 family. http://togogenome.org/gene/9597:KIF5C ^@ http://purl.uniprot.org/uniprot/A0A2R9AM90 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9597:BCL2L10 ^@ http://purl.uniprot.org/uniprot/A0A2R9BCD9 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9597:SLC39A10 ^@ http://purl.uniprot.org/uniprot/A0A2R9CCD6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:CCNG2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C0Z0 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9597:INIP ^@ http://purl.uniprot.org/uniprot/A0A2R9CLS5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SOSS-C family.|||Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).|||Component of the SOSS complex.|||Nucleus http://togogenome.org/gene/9597:AURKAIP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B7S4 ^@ Similarity ^@ Belongs to the mitochondrion-specific ribosomal protein mS38 family. http://togogenome.org/gene/9597:IMP4 ^@ http://purl.uniprot.org/uniprot/A0A2R9A6L9 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9597:LOC100986707 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase VIIb family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9597:EPCAM ^@ http://purl.uniprot.org/uniprot/A0A2R9A8B2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPCAM family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lateral cell membrane|||May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.|||Membrane|||tight junction http://togogenome.org/gene/9597:PDIA4 ^@ http://purl.uniprot.org/uniprot/A0A2R9ALF2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen|||Part of a large chaperone multiprotein complex. http://togogenome.org/gene/9597:PRKCE ^@ http://purl.uniprot.org/uniprot/A0A2R9AUU7 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration.|||Cell membrane|||Cytoplasm|||Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.|||Nucleus|||cytoskeleton|||perinuclear region http://togogenome.org/gene/9597:ADAM28 ^@ http://purl.uniprot.org/uniprot/A0A2R9B5R7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:MRPL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C628 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9597:HHATL ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYE8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:PRDX2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B3Q2 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/9597:IL4R ^@ http://purl.uniprot.org/uniprot/A0A2R9C7J4 ^@ Function|||Similarity ^@ Belongs to the type I cytokine receptor family. Type 4 subfamily.|||Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. http://togogenome.org/gene/9597:NSUN7 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLK5|||http://purl.uniprot.org/uniprot/A0A2R8ZMM2 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:DYNC1LI1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BEJ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.|||Belongs to the dynein light intermediate chain family.|||Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).|||cytoskeleton http://togogenome.org/gene/9597:NUDT3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AF93 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DIPP subfamily. http://togogenome.org/gene/9597:GALM ^@ http://purl.uniprot.org/uniprot/A0A2R9BWD9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the aldose epimerase family.|||Monomer.|||Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. http://togogenome.org/gene/9597:GSX2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACH4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:CCT3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CAM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9597:POGK ^@ http://purl.uniprot.org/uniprot/A0A2R9BIY7 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:DEFB119 ^@ http://purl.uniprot.org/uniprot/A0A2R9A5R6|||http://purl.uniprot.org/uniprot/A0A2R9AAI0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9597:CD34 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTK3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:ACAT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B6L3 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/9597:MATK ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAM3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9597:PANX1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7D5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Membrane|||S-nitrosylation inhibits channel currents and ATP release.|||Structural component of the gap junctions and the hemichannels.|||gap junction http://togogenome.org/gene/9597:PRR15L ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7H9 ^@ Similarity ^@ Belongs to the PRR15 family. http://togogenome.org/gene/9597:ANXA11 ^@ http://purl.uniprot.org/uniprot/A0A2R9B7V6|||http://purl.uniprot.org/uniprot/A0A2R9B9B5 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9597:HDAC6 ^@ http://purl.uniprot.org/uniprot/A0A2R9AX84 ^@ Similarity ^@ Belongs to the histone deacetylase family. HD type 2 subfamily. http://togogenome.org/gene/9597:HSPA4L ^@ http://purl.uniprot.org/uniprot/A0A2R9A3Z5 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9597:FHIP1B ^@ http://purl.uniprot.org/uniprot/A0A2R9AI96 ^@ Similarity ^@ Belongs to the FHIP family. http://togogenome.org/gene/9597:PIK3C2B ^@ http://purl.uniprot.org/uniprot/A0A2R9AIX4 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9597:SPO11 ^@ http://purl.uniprot.org/uniprot/A0A2R9B8U8|||http://purl.uniprot.org/uniprot/A0A2R9BGA0 ^@ Similarity ^@ Belongs to the TOP6A family. http://togogenome.org/gene/9597:TSHZ2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AIL8 ^@ Similarity ^@ Belongs to the teashirt C2H2-type zinc-finger protein family. http://togogenome.org/gene/9597:LVRN ^@ http://purl.uniprot.org/uniprot/A0A2R9BDU8 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9597:NAPG ^@ http://purl.uniprot.org/uniprot/A0A2R9B7E9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/9597:GPRIN3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIS6 ^@ Function ^@ May be involved in neurite outgrowth. http://togogenome.org/gene/9597:KIF2C ^@ http://purl.uniprot.org/uniprot/A0A2R9CP97|||http://purl.uniprot.org/uniprot/A0A2R9CTM1 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9597:TMEM91 ^@ http://purl.uniprot.org/uniprot/A0A2R9BNY8 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9597:SLFN5 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJB5 ^@ Similarity ^@ Belongs to the Schlafen family. Subgroup III subfamily. http://togogenome.org/gene/9597:ZNF81 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZW46 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:SULT1E1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSI9 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9597:SLC31A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9597:RGS4 ^@ http://purl.uniprot.org/uniprot/A0A2R9ANC1 ^@ Function ^@ Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. http://togogenome.org/gene/9597:ZNF607 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z8N5 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:KCNS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BES1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:CCL21 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHA3 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9597:HYOU1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZB00 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9597:SEPTIN3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHA8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cytoplasm|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9597:ACP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AGN1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.|||Belongs to the low molecular weight phosphotyrosine protein phosphatase family.|||Cytoplasm http://togogenome.org/gene/9597:GJC1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCV4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins. Interacts with CNST.|||Belongs to the connexin family. Gamma-type subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9597:CRY1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDU0 ^@ Cofactor|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/9597:CDC123 ^@ http://purl.uniprot.org/uniprot/A0A2R9BXU5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC123 family.|||Cytoplasm|||Required for S phase entry of the cell cycle. http://togogenome.org/gene/9597:SELENOS ^@ http://purl.uniprot.org/uniprot/A0A2R9ADX4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the selenoprotein S family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.|||Membrane http://togogenome.org/gene/9597:NIBAN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9APM5 ^@ Similarity ^@ Belongs to the Niban family. http://togogenome.org/gene/9597:LOC100981444 ^@ http://purl.uniprot.org/uniprot/Q646C7 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane|||Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.|||Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). http://togogenome.org/gene/9597:PPM1G ^@ http://purl.uniprot.org/uniprot/A0A2R9BH01 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9597:CRKL ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJE4 ^@ Similarity ^@ Belongs to the CRK family. http://togogenome.org/gene/9597:GFRA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AIA1|||http://purl.uniprot.org/uniprot/A0A2R9AQD8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.|||Belongs to the GDNFR family.|||Cell membrane|||Membrane|||Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. http://togogenome.org/gene/9597:PMPCA ^@ http://purl.uniprot.org/uniprot/A0A2R9BJK8 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/9597:SLC5A5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:DAZAP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4E0 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus speckle|||nuclear body http://togogenome.org/gene/9597:MEGF9 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6A4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:ST8SIA5 ^@ http://purl.uniprot.org/uniprot/A0A2R9ANX6|||http://purl.uniprot.org/uniprot/A0A2R9APF8|||http://purl.uniprot.org/uniprot/A0A2R9ATE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9597:LOC100977675 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJR5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:CYP2A13 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAN8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9597:MTFR1L ^@ http://purl.uniprot.org/uniprot/A0A2R9AG98 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission. http://togogenome.org/gene/9597:TIGD4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZD26 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:MFSD8 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFD7|||http://purl.uniprot.org/uniprot/A0A2R8ZFW1|||http://purl.uniprot.org/uniprot/A0A2R8ZLV6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:SEC61A1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJ95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:ARMC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C8U4 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9597:GABRR3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJ01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9597:SRPX ^@ http://purl.uniprot.org/uniprot/A0A2R9BCH1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:CAV1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BGE7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||caveola http://togogenome.org/gene/9597:CLDN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B835 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9597:PLCD1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZR69 ^@ Cofactor ^@ Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain. http://togogenome.org/gene/9597:GALE ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDL9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family.|||Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.|||Homodimer. http://togogenome.org/gene/9597:C8B ^@ http://purl.uniprot.org/uniprot/A0A2R9C373 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9597:ANTXR2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATR family.|||Membrane http://togogenome.org/gene/9597:CLIC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9APF0 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cell membrane|||Cytoplasm|||Endoplasmic reticulum|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane|||Nucleus membrane http://togogenome.org/gene/9597:SLC4A10 ^@ http://purl.uniprot.org/uniprot/A0A2R9BY66 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9597:CCT6B ^@ http://purl.uniprot.org/uniprot/A0A2R9BEW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9597:LOC100994149 ^@ http://purl.uniprot.org/uniprot/A0A2R9B881 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9597:GBP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4A8 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9597:DEFB121 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABI8|||http://purl.uniprot.org/uniprot/A0A2R9AC16 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9597:OAZ1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B0A3 ^@ Similarity ^@ Belongs to the ODC antizyme family. http://togogenome.org/gene/9597:IFIH1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/9597:GLYAT ^@ http://purl.uniprot.org/uniprot/A0A2R9BLT6 ^@ Similarity ^@ Belongs to the glycine N-acyltransferase family. http://togogenome.org/gene/9597:MID1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BLE9 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9597:TMEM11 ^@ http://purl.uniprot.org/uniprot/A0A2R9CG01|||http://purl.uniprot.org/uniprot/A0A2R9CQB8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM11 family.|||Membrane|||Plays a role in mitochondrial morphogenesis. http://togogenome.org/gene/9597:OLFM4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BC21 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:ALPI ^@ http://purl.uniprot.org/uniprot/A0A2R9AW48 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alkaline phosphatase family.|||Binds 1 Mg(2+) ion.|||Binds 2 Zn(2+) ions.|||Cell membrane|||Homodimer.|||Membrane http://togogenome.org/gene/9597:COPS4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZN25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN4 family.|||Nucleus|||Vesicle|||synaptic vesicle http://togogenome.org/gene/9597:AJUBA ^@ http://purl.uniprot.org/uniprot/A0A2R9AHL0 ^@ Similarity ^@ Belongs to the zyxin/ajuba family. http://togogenome.org/gene/9597:LOC100976130 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAD8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:FTMT ^@ http://purl.uniprot.org/uniprot/A0A2R8ZN40 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/9597:UNC5C ^@ http://purl.uniprot.org/uniprot/A0A2R9C6D2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-5 family.|||Cell membrane|||Membrane|||Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. http://togogenome.org/gene/9597:TRDMT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ATZ5 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. http://togogenome.org/gene/9597:EPC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AP37|||http://purl.uniprot.org/uniprot/A0A2R9ASZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enhancer of polycomb family.|||Nucleus http://togogenome.org/gene/9597:SNW1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C2Z2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNW family.|||Identified in the spliceosome C complex.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/9597:TMEM256 ^@ http://purl.uniprot.org/uniprot/A0A2R9BY16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM256 family.|||Membrane http://togogenome.org/gene/9597:TOR2A ^@ http://purl.uniprot.org/uniprot/A0A2R9C7V2|||http://purl.uniprot.org/uniprot/A0A2R9CIE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ClpA/ClpB family. Torsin subfamily.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9597:POLR2K ^@ http://purl.uniprot.org/uniprot/A0A2R9C346 ^@ Similarity ^@ Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family. http://togogenome.org/gene/9597:HOXC4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BS03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9597:PPP1CC ^@ http://purl.uniprot.org/uniprot/A0A2R9AE39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family. PP-1 subfamily.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9597:TPD52L1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZWU2 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/9597:LECT2 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z767 ^@ Similarity ^@ Belongs to the LECT2/MIM-1 family. http://togogenome.org/gene/9597:SOX14 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCF2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:SNX11 ^@ http://purl.uniprot.org/uniprot/A0A2R9ARH1|||http://purl.uniprot.org/uniprot/A0A2R9ARZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane http://togogenome.org/gene/9597:CAMK2D ^@ http://purl.uniprot.org/uniprot/A0A2R9AEX7|||http://purl.uniprot.org/uniprot/A0A2R9AEY3|||http://purl.uniprot.org/uniprot/A0A2R9AFW6|||http://purl.uniprot.org/uniprot/A0A2R9AJS9|||http://purl.uniprot.org/uniprot/A0A2R9AJT5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9597:SLC30A4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CMM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9597:OSBPL3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B046|||http://purl.uniprot.org/uniprot/A0A2R9B2X6 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9597:VSX1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYB3|||http://purl.uniprot.org/uniprot/A0A2R9BYB8|||http://purl.uniprot.org/uniprot/A0A2R9C1L9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:PSMD4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AIV2 ^@ Similarity ^@ Belongs to the proteasome subunit S5A family. http://togogenome.org/gene/9597:DBNDD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AE53 ^@ Similarity ^@ Belongs to the dysbindin family. http://togogenome.org/gene/9597:SYNGR4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CHQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptogyrin family.|||Membrane http://togogenome.org/gene/9597:GIMAP8 ^@ http://purl.uniprot.org/uniprot/A0A2R9BXT4 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9597:PPIL3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSM7 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9597:CYP11A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AUS6|||http://purl.uniprot.org/uniprot/A0A2R9AYY8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).|||Belongs to the cytochrome P450 family.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:PPA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDE9|||http://purl.uniprot.org/uniprot/A0A2R9CNU0 ^@ Similarity ^@ Belongs to the PPase family. http://togogenome.org/gene/9597:SRP14 ^@ http://purl.uniprot.org/uniprot/A0A2R9CPG2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SRP14 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.|||Cytoplasm|||Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. http://togogenome.org/gene/9597:GNG3 ^@ http://purl.uniprot.org/uniprot/A0A2R9ASX5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9597:IER3IP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A3N8 ^@ Similarity ^@ Belongs to the YOS1 family. http://togogenome.org/gene/9597:TYRO3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BVM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.|||Membrane http://togogenome.org/gene/9597:INTS7 ^@ http://purl.uniprot.org/uniprot/A0A2R9CGY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 7 family.|||Nucleus http://togogenome.org/gene/9597:LOC103784643 ^@ http://purl.uniprot.org/uniprot/A0A2R9BRC2 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:LOC100988170 ^@ http://purl.uniprot.org/uniprot/A0A2R9APD1 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9597:SNX2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJ74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome membrane|||Endosome membrane|||Membrane|||lamellipodium http://togogenome.org/gene/9597:ATP6V1C1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AF38 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits. http://togogenome.org/gene/9597:CCL13 ^@ http://purl.uniprot.org/uniprot/A0A2R9C8T3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9597:CNOT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CD80 ^@ Similarity ^@ Belongs to the CNOT2/3/5 family. http://togogenome.org/gene/9597:MARK2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQR7|||http://purl.uniprot.org/uniprot/A0A2R9AR61|||http://purl.uniprot.org/uniprot/A0A2R9AR77|||http://purl.uniprot.org/uniprot/A0A2R9AV64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||dendrite http://togogenome.org/gene/9597:HHEX ^@ http://purl.uniprot.org/uniprot/A0A2R9B8R3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:LOC100973020 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9A0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Secreted http://togogenome.org/gene/9597:APC ^@ http://purl.uniprot.org/uniprot/A0A2R9AUR0 ^@ Similarity ^@ Belongs to the adenomatous polyposis coli (APC) family. http://togogenome.org/gene/9597:DBNDD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BLB3 ^@ Similarity ^@ Belongs to the dysbindin family. http://togogenome.org/gene/9597:MARK3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AEA1|||http://purl.uniprot.org/uniprot/A0A2R9AJ56|||http://purl.uniprot.org/uniprot/A0A2R9AKV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||dendrite http://togogenome.org/gene/9597:MFGE8 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZY45|||http://purl.uniprot.org/uniprot/A0A2R8ZY53 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:CSNK2A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AMW1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:NONO ^@ http://purl.uniprot.org/uniprot/A0A2R9ANT1 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/9597:AMER1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZC97 ^@ Similarity ^@ Belongs to the Amer family. http://togogenome.org/gene/9597:LOC100974682 ^@ http://purl.uniprot.org/uniprot/A0A2R9BIW8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9597:DMPK ^@ http://purl.uniprot.org/uniprot/A0A2R9CH60|||http://purl.uniprot.org/uniprot/A0A2R9CH69 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily. http://togogenome.org/gene/9597:CASR ^@ http://purl.uniprot.org/uniprot/A0A2R9BDK2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:ZNF230 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZK98 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:RHBDD3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BIW6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:PFKFB4 ^@ http://purl.uniprot.org/uniprot/A0A2R9C0V9 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/9597:GRM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CQ41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:KIZ ^@ http://purl.uniprot.org/uniprot/A0A2R9ALG6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the kizuna family.|||Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.|||centrosome|||cilium basal body http://togogenome.org/gene/9597:CDK1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C1X9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:DMTF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B7A4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:TSPAN17 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9597:PAQR4 ^@ http://purl.uniprot.org/uniprot/A0A2R9A4F9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9597:PDE5A ^@ http://purl.uniprot.org/uniprot/A0A2R9CF87|||http://purl.uniprot.org/uniprot/A0A2R9CFA2 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9597:CUTA ^@ http://purl.uniprot.org/uniprot/A0A2R9BHL2 ^@ Similarity|||Subunit ^@ Belongs to the CutA family.|||Homotrimer. http://togogenome.org/gene/9597:OGN ^@ http://purl.uniprot.org/uniprot/A0A2R9C3Y2 ^@ Similarity ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. http://togogenome.org/gene/9597:SRD5A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BNM1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Microsome membrane http://togogenome.org/gene/9597:MMP8 ^@ http://purl.uniprot.org/uniprot/A0A2R9A8Y9 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9597:DNPEP ^@ http://purl.uniprot.org/uniprot/A0A2R9ARD6 ^@ Similarity|||Subunit ^@ Belongs to the peptidase M18 family.|||Tetrahedron-shaped homododecamer built from six homodimers. http://togogenome.org/gene/9597:NDUFB6 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUN8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB6 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:DLG1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AUP6|||http://purl.uniprot.org/uniprot/A0A2R9AUP8|||http://purl.uniprot.org/uniprot/A0A2R9B0W9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Membrane http://togogenome.org/gene/9597:DCP1B ^@ http://purl.uniprot.org/uniprot/A0A2R9APP8 ^@ Similarity ^@ Belongs to the DCP1 family. http://togogenome.org/gene/9597:ACTL7B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJL1 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9597:THOC7 ^@ http://purl.uniprot.org/uniprot/A0A2R9CM75 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the THOC7 family.|||Nucleus|||Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. http://togogenome.org/gene/9597:IZUMO1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1Y2 ^@ Similarity ^@ Belongs to the Izumo family. http://togogenome.org/gene/9597:DUOXA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AAZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DUOXA family.|||Membrane http://togogenome.org/gene/9597:LDLRAD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BH37 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:RANBP10 ^@ http://purl.uniprot.org/uniprot/A0A2R9BMZ7 ^@ Similarity ^@ Belongs to the RANBP9/10 family. http://togogenome.org/gene/9597:ADRM1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADRM1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:PTGS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CG18 ^@ Caution|||Similarity ^@ Belongs to the prostaglandin G/H synthase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:TBC1D31 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1C1|||http://purl.uniprot.org/uniprot/A0A2R9A5R0 ^@ Function|||Subcellular Location Annotation ^@ Molecular adapter which is involved in cilium biogenesis. Part of a functional complex including OFD1 a centriolar protein involved in cilium assembly. Could regulate the cAMP-dependent phosphorylation of OFD1, and its subsequent ubiquitination by PJA2 which ultimately leads to its proteasomal degradation.|||centriolar satellite|||cilium basal body http://togogenome.org/gene/9597:PRICKLE1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CEK7 ^@ Similarity ^@ Belongs to the prickle / espinas / testin family. http://togogenome.org/gene/9597:BEND6 ^@ http://purl.uniprot.org/uniprot/A0A2R9BQJ0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:TUBE1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTN8 ^@ Similarity ^@ Belongs to the tubulin family. http://togogenome.org/gene/9597:RNASE6 ^@ http://purl.uniprot.org/uniprot/A0A2R9ASD4 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9597:GRK7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BHZ3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9597:NDRG4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BG45|||http://purl.uniprot.org/uniprot/A0A2R9BG55|||http://purl.uniprot.org/uniprot/A0A2R9BH21 ^@ Similarity ^@ Belongs to the NDRG family. http://togogenome.org/gene/9597:DDI1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIX9 ^@ Similarity ^@ Belongs to the DDI1 family. http://togogenome.org/gene/9597:SLC25A1 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7R9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9597:GMPPB ^@ http://purl.uniprot.org/uniprot/A0A2R9ANZ8|||http://purl.uniprot.org/uniprot/A0A2R9ATG2 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/9597:GOLT1B ^@ http://purl.uniprot.org/uniprot/A0A2R9AI84 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||May be involved in fusion of ER-derived transport vesicles with the Golgi complex.|||Membrane http://togogenome.org/gene/9597:MAST1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B7I8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/9597:TNPO1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CNL4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:ALDH1B1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAD4 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9597:TAF7L ^@ http://purl.uniprot.org/uniprot/A0A2R9ACS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF7 family.|||Nucleus http://togogenome.org/gene/9597:ATP10D ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9597:GATA2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVR6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:SLC2A8 ^@ http://purl.uniprot.org/uniprot/A0A2R9AB25 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/9597:COQ8A ^@ http://purl.uniprot.org/uniprot/A0A2R9BPY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family.|||Membrane http://togogenome.org/gene/9597:MAPK10 ^@ http://purl.uniprot.org/uniprot/A0A2R9CES1|||http://purl.uniprot.org/uniprot/A0A2R9CEV4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/9597:LOC100976603 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJR1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:PAGE4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BI72 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9597:SNAP25 ^@ http://purl.uniprot.org/uniprot/A0A2R9A2V1|||http://purl.uniprot.org/uniprot/A0A2R9A2V4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNAP-25 family.|||Cell membrane|||Membrane|||Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.|||Photoreceptor inner segment|||synaptosome|||t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. http://togogenome.org/gene/9597:HTR3A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZL47|||http://purl.uniprot.org/uniprot/A0A2R8ZM85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:NSUN6 ^@ http://purl.uniprot.org/uniprot/A0A2R9CEG7 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/9597:TSC22D4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CRS5 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/9597:PTDSS2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZU87 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphatidyl serine synthase family.|||Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:ETV5 ^@ http://purl.uniprot.org/uniprot/A0A2R9A101 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9597:RAD18 ^@ http://purl.uniprot.org/uniprot/A0A2R9BAL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAD18 family.|||Nucleus http://togogenome.org/gene/9597:LAMC3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AYI2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||basement membrane http://togogenome.org/gene/9597:CSNK2B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZW67 ^@ Function|||Similarity|||Subunit ^@ Belongs to the casein kinase 2 subunit beta family.|||Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/9597:SLC6A20 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9597:PLA2G2A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCM9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9597:TOP1MT ^@ http://purl.uniprot.org/uniprot/A0A2R9AZF9|||http://purl.uniprot.org/uniprot/A0A2R9B3H0 ^@ Function|||Similarity ^@ Belongs to the type IB topoisomerase family.|||Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/9597:SMIM19 ^@ http://purl.uniprot.org/uniprot/A0A2R9B4S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM19 family.|||Membrane http://togogenome.org/gene/9597:PFDN4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CGH9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/9597:GGT6 ^@ http://purl.uniprot.org/uniprot/A0A2R9BVE5|||http://purl.uniprot.org/uniprot/A0A2R9BY67 ^@ Similarity ^@ Belongs to the gamma-glutamyltransferase family. http://togogenome.org/gene/9597:RAMP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B9U4 ^@ Similarity ^@ Belongs to the RAMP family. http://togogenome.org/gene/9597:SDE2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BHI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SDE2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:PIPOX ^@ http://purl.uniprot.org/uniprot/A0A2R9B5D3 ^@ Similarity ^@ Belongs to the MSOX/MTOX family. http://togogenome.org/gene/9597:MPPED2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLC2 ^@ Similarity ^@ Belongs to the UPF0046 family. http://togogenome.org/gene/9597:TRAF3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZXR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/9597:TICAM1 ^@ http://purl.uniprot.org/uniprot/B3Y693 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Homodimer. Found in a multi-helicase-TICAM1 complex at least composed of DHX36, DDX1, DDX21 and TICAM1.|||Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines.|||Mitochondrion|||The N-terminal region is essential for activation of the IFNB promoter activity.|||autophagosome|||cytosol http://togogenome.org/gene/9597:PTGDS ^@ http://purl.uniprot.org/uniprot/A0A2R9C782 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9597:ENO2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C6K1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/9597:SLC16A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AET5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/9597:NR1D1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CEW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9597:LOC100994951 ^@ http://purl.uniprot.org/uniprot/A0A2R9A2P3 ^@ Similarity ^@ Belongs to the ficolin lectin family. http://togogenome.org/gene/9597:B4GALT4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXY0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9597:SSBP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B575 ^@ Subcellular Location Annotation ^@ mitochondrion nucleoid http://togogenome.org/gene/9597:FAM167A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHJ9 ^@ Similarity ^@ Belongs to the FAM167 (SEC) family. http://togogenome.org/gene/9597:GPBP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVE5|||http://purl.uniprot.org/uniprot/A0A2R9A114 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vasculin family.|||Nucleus http://togogenome.org/gene/9597:SYT17 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNJ8|||http://purl.uniprot.org/uniprot/A0A2R8ZT97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Membrane http://togogenome.org/gene/9597:SERPINB8 ^@ http://purl.uniprot.org/uniprot/A0A2R9AD47 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9597:GLCE ^@ http://purl.uniprot.org/uniprot/A0A2R9AWN9 ^@ Similarity ^@ Belongs to the D-glucuronyl C5-epimerase family. http://togogenome.org/gene/9597:TMEM231 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYB0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM231 family.|||Membrane|||Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.|||cilium membrane http://togogenome.org/gene/9597:TUBD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AIX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin family.|||Nucleus|||centriole|||cilium http://togogenome.org/gene/9597:COL4A1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQ62 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.|||basement membrane http://togogenome.org/gene/9597:CNN3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A0L2 ^@ Function|||Similarity ^@ Belongs to the calponin family.|||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. http://togogenome.org/gene/9597:KCNJ6 ^@ http://purl.uniprot.org/uniprot/A0A2R9ASG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.|||Membrane http://togogenome.org/gene/9597:POU3F4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-3 subfamily.|||Nucleus http://togogenome.org/gene/9597:LOC100992550 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJC7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9597:ACKR4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFQ0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9597:KAT5 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9W8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/9597:NAGK ^@ http://purl.uniprot.org/uniprot/A0A2R9BU47 ^@ Similarity ^@ Belongs to the eukaryotic-type N-acetylglucosamine kinase family. http://togogenome.org/gene/9597:ADCY3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BLU9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/9597:LOC100972036 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCU4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:ATP1B1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BHW2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9597:BLOC1S6 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6N0|||http://purl.uniprot.org/uniprot/A0A2R8ZAC9 ^@ Function|||Similarity ^@ Belongs to the BLOC1S6 family.|||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process. http://togogenome.org/gene/9597:PACSIN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BEV2|||http://purl.uniprot.org/uniprot/A0A2R9BHF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PACSIN family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Early endosome|||Endosome membrane|||Membrane|||Recycling endosome membrane|||caveola|||cytoskeleton|||ruffle membrane http://togogenome.org/gene/9597:ACADL ^@ http://purl.uniprot.org/uniprot/A0A2R9B7K7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acyl-CoA dehydrogenase family.|||Homotetramer.|||Mitochondrion matrix http://togogenome.org/gene/9597:ARF6 ^@ http://purl.uniprot.org/uniprot/A0A2R9AS00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||Cell membrane|||Cleavage furrow|||Endosome membrane|||Midbody ring|||Recycling endosome membrane|||filopodium membrane|||ruffle http://togogenome.org/gene/9597:PTS ^@ http://purl.uniprot.org/uniprot/A0A2R9AR91 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the PTPS family.|||Binds 1 zinc ion per subunit.|||Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. http://togogenome.org/gene/9597:SPIN4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMM1 ^@ Similarity ^@ Belongs to the SPIN/STSY family. http://togogenome.org/gene/9597:ALKBH2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AWD5 ^@ Similarity ^@ Belongs to the alkB family. http://togogenome.org/gene/9597:ASB9 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJ65 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9597:SEC24C ^@ http://purl.uniprot.org/uniprot/A0A2R9C4I0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9597:S1PR2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZI74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:MTIF3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZT32 ^@ Similarity ^@ Belongs to the IF-3 family. http://togogenome.org/gene/9597:HOXD3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AIR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9597:PSMD3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A3G8 ^@ Similarity ^@ Belongs to the proteasome subunit S3 family. http://togogenome.org/gene/9597:PLD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AP38 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/9597:RNASEH2A ^@ http://purl.uniprot.org/uniprot/A0A2R9A386 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the RNase HII family. Eukaryotic subfamily.|||Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/9597:C1H1orf174 ^@ http://purl.uniprot.org/uniprot/A0A2R9AGB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0688 family.|||Nucleus http://togogenome.org/gene/9597:ATG5 ^@ http://purl.uniprot.org/uniprot/A0A2R9C3I9|||http://purl.uniprot.org/uniprot/A0A2R9C3J6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG5 family.|||Conjugated with ATG12.|||Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.|||May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.|||Preautophagosomal structure membrane http://togogenome.org/gene/9597:TMED5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVQ1|||http://purl.uniprot.org/uniprot/A0A2R8ZXX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9597:TRUB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJH9 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/9597:NAGA ^@ http://purl.uniprot.org/uniprot/A0A2R9AYK2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 27 family.|||Homodimer.|||Lysosome http://togogenome.org/gene/9597:PPM1D ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJH3 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9597:CUL4B ^@ http://purl.uniprot.org/uniprot/A0A2R9A0U8 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9597:MRAP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AGW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRAP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:STEAP4 ^@ http://purl.uniprot.org/uniprot/A0A2R9ANB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9597:ACTG2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A4B9|||http://purl.uniprot.org/uniprot/A0A2R9A5I8 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9597:CDIP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/9597:UBA5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZX54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.|||Endoplasmic reticulum membrane|||Golgi apparatus http://togogenome.org/gene/9597:DLX2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus http://togogenome.org/gene/9597:ASIC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BGA3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:RECQL5 ^@ http://purl.uniprot.org/uniprot/A0A2R9B0M6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RecQ subfamily.|||Nucleus http://togogenome.org/gene/9597:LOC100991103 ^@ http://purl.uniprot.org/uniprot/A0A2R9CG76|||http://purl.uniprot.org/uniprot/A0A2R9CGD5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Inflammasome http://togogenome.org/gene/9597:LOC100989330 ^@ http://purl.uniprot.org/uniprot/A0A2R9ANA7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9597:KRT19 ^@ http://purl.uniprot.org/uniprot/A0A2R9ALU5 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9597:THTPA ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVM2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ThTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Hydrolase highly specific for thiamine triphosphate (ThTP).|||Monomer. http://togogenome.org/gene/9597:DZIP3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1G2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:CDH3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYH8 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:L3MBTL3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5Z8|||http://purl.uniprot.org/uniprot/A0A2R9C8T6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:FOXI2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTX1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:RPP30 ^@ http://purl.uniprot.org/uniprot/A0A2R9CKB0 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal RNase P protein component 3 family. http://togogenome.org/gene/9597:MON1B ^@ http://purl.uniprot.org/uniprot/A0A2R9A9T8 ^@ Function|||Similarity ^@ Belongs to the MON1/SAND family.|||Plays an important role in membrane trafficking through the secretory apparatus. http://togogenome.org/gene/9597:PIGC ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGC family.|||Membrane http://togogenome.org/gene/9597:RBBP5 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7Y3|||http://purl.uniprot.org/uniprot/A0A2R8ZEB6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:LONP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AV09 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.|||Belongs to the peptidase S16 family.|||Interacts with PEX5. Interacts with TYSND1.|||Peroxisome matrix http://togogenome.org/gene/9597:CCKAR ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVR1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9597:HYCC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C234 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Hyccin family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/9597:ADAM19 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQB2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:TTC39C ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMS9 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/9597:ATP5MC3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BB70 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/9597:CCNY ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQK7 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin Y subfamily. http://togogenome.org/gene/9597:NTS ^@ http://purl.uniprot.org/uniprot/A0A2R9ANN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurotensin family.|||Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.|||Secreted|||Vesicle|||secretory vesicle http://togogenome.org/gene/9597:WAPL ^@ http://purl.uniprot.org/uniprot/A0A2R9CBY1 ^@ Similarity ^@ Belongs to the WAPL family. http://togogenome.org/gene/9597:TBC1D7 ^@ http://purl.uniprot.org/uniprot/A0A2R9CLM0|||http://purl.uniprot.org/uniprot/A0A2R9CS18 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Vesicle http://togogenome.org/gene/9597:PLA2G15 ^@ http://purl.uniprot.org/uniprot/A0A2R9CBJ6 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9597:ABCD4 ^@ http://purl.uniprot.org/uniprot/A0A2R9C8E5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:ZDHHC20 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABG1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9597:LOC100992901 ^@ http://purl.uniprot.org/uniprot/A0A2R9ASN6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:VWF ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVE3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.|||Multimeric. Interacts with F8.|||Secreted|||extracellular matrix http://togogenome.org/gene/9597:SUGCT ^@ http://purl.uniprot.org/uniprot/A0A2R9CG36 ^@ Similarity ^@ Belongs to the CoA-transferase III family. http://togogenome.org/gene/9597:TNFAIP6 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACW6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:ZNF845 ^@ http://purl.uniprot.org/uniprot/A0A2R9B965 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:BAX ^@ http://purl.uniprot.org/uniprot/A0A2R9BX16 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9597:EIF3K ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTV9|||http://purl.uniprot.org/uniprot/A0A2R8ZV29 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit K family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with CCND3, but not with CCND1 and CCND2.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:INSL6 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z728 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||May have a role in sperm development and fertilization.|||Secreted http://togogenome.org/gene/9597:ITGA3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AVE9|||http://purl.uniprot.org/uniprot/A0A2R9AZJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9597:SMG6 ^@ http://purl.uniprot.org/uniprot/A0A2R9CK46 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini.|||Plays a role in nonsense-mediated mRNA decay.|||The PINc domain confers endonuclease activity and is expected to bind the catalytic metal ion.|||cytosol|||nucleolus|||telomere http://togogenome.org/gene/9597:LRWD1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRWD1 family.|||centrosome|||kinetochore|||telomere http://togogenome.org/gene/9597:HOATZ ^@ http://purl.uniprot.org/uniprot/A0A2R9A431|||http://purl.uniprot.org/uniprot/A0A2R9A436 ^@ Similarity ^@ Belongs to the HOATZ family. http://togogenome.org/gene/9597:HOXC12 ^@ http://purl.uniprot.org/uniprot/A0A2R9AD08 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:ZNF460 ^@ http://purl.uniprot.org/uniprot/A0A2R9C8I3 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:NDUFB2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BWD7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB2 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:GOLM2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZY29|||http://purl.uniprot.org/uniprot/A0A2R9A2I0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLM family.|||Membrane http://togogenome.org/gene/9597:ANAPC15 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZH31 ^@ Similarity ^@ Belongs to the APC15 family. http://togogenome.org/gene/9597:USP37 ^@ http://purl.uniprot.org/uniprot/A0A2R9A530 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9597:RPL15 ^@ http://purl.uniprot.org/uniprot/A0A2R9ARX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL15 family.|||Cytoplasm http://togogenome.org/gene/9597:MIEF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CEC2 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9597:TMA16 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9K2 ^@ Function|||Similarity|||Subunit ^@ Associates with pre-60S ribosomal particles.|||Belongs to the TMA16 family.|||Involved in the biogenesis of the 60S ribosomal subunit in the nucleus. http://togogenome.org/gene/9597:ALOX15 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABT1 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the lipoxygenase family.|||Binds 1 Fe cation per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:ELF4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9597:MARVELD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9APH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9597:SLC12A5 ^@ http://purl.uniprot.org/uniprot/A0A2R9CFZ8|||http://purl.uniprot.org/uniprot/A0A2R9CIQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9597:F10 ^@ http://purl.uniprot.org/uniprot/A0A2R9B696 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9597:TAFA3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUI9 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/9597:MRPS18C ^@ http://purl.uniprot.org/uniprot/A0A2R9BEQ3|||http://purl.uniprot.org/uniprot/A0A2R9BIL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Mitochondrion http://togogenome.org/gene/9597:HOMEZ ^@ http://purl.uniprot.org/uniprot/A0A2R9BK87 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:HTR2A ^@ http://purl.uniprot.org/uniprot/A0A2R8Z5S4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasmic vesicle|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin).|||Membrane|||Presynapse|||Synapse|||Vesicle|||axon|||caveola|||dendrite http://togogenome.org/gene/9597:C1H1orf74 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKQ9 ^@ Similarity ^@ Belongs to the UPF0739 family. http://togogenome.org/gene/9597:SARM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B3Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SARM1 family.|||axon http://togogenome.org/gene/9597:ZNF235 ^@ http://purl.uniprot.org/uniprot/A0A2R9AI52 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:ZW10 ^@ http://purl.uniprot.org/uniprot/A0A2R9AI36|||http://purl.uniprot.org/uniprot/A0A2R9ALY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZW10 family.|||kinetochore http://togogenome.org/gene/9597:NECAP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CG30 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NECAP family.|||Involved in endocytosis.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9597:POLL ^@ http://purl.uniprot.org/uniprot/A0A2R9BHW8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.|||Nucleus http://togogenome.org/gene/9597:RIBC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A302 ^@ Similarity ^@ Belongs to the RIB43A family. http://togogenome.org/gene/9597:CCNI ^@ http://purl.uniprot.org/uniprot/A0A2R9C8T1 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9597:SLC27A6 ^@ http://purl.uniprot.org/uniprot/A0A2R9CCJ0 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9597:TFEC ^@ http://purl.uniprot.org/uniprot/A0A2R8Z8K1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/9597:CHMP5 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXJ7 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9597:DUSP26 ^@ http://purl.uniprot.org/uniprot/A0A2R9BXG4 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/9597:TSPAN6 ^@ http://purl.uniprot.org/uniprot/A0A2R9BMU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9597:EHD3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B5I7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/9597:REV1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ALL6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-Y family.|||Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.|||Nucleus http://togogenome.org/gene/9597:SLC10A2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/9597:AMHR2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZS02|||http://purl.uniprot.org/uniprot/A0A2R8ZS13 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane|||On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. http://togogenome.org/gene/9597:NDUFA11 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMW9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA11 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:TSR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BAB2 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9597:CERS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BW56 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9597:THUMPD3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQS5 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/9597:COG6 ^@ http://purl.uniprot.org/uniprot/A0A2R9BPS0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COG6 family.|||Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.|||Golgi apparatus membrane|||Membrane|||Required for normal Golgi function. http://togogenome.org/gene/9597:SNRPB ^@ http://purl.uniprot.org/uniprot/A0A2R9BA24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP SmB/SmN family.|||Nucleus http://togogenome.org/gene/9597:EXO1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BS47 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.|||Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Nucleus http://togogenome.org/gene/9597:LOC100972973 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9P1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:ELOVL5 ^@ http://purl.uniprot.org/uniprot/A0A2R9B7U0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL5 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Membrane|||dendrite http://togogenome.org/gene/9597:LIMK2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BXG1|||http://purl.uniprot.org/uniprot/A0A2R9BY65 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. http://togogenome.org/gene/9597:IFI35 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9X2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NMI family.|||Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/9597:SGSM3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AIN2 ^@ Similarity ^@ Belongs to the small G protein signaling modulator family. http://togogenome.org/gene/9597:SLC20A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A132 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter. http://togogenome.org/gene/9597:SP4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BDR5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:NEK8 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBY5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. http://togogenome.org/gene/9597:CAPN7 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQ47 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9597:TOMM20L ^@ http://purl.uniprot.org/uniprot/A0A2R9CL66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom20 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9597:SLC35B1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BLW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/9597:TSEN15 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJ54 ^@ Similarity ^@ Belongs to the SEN15 family. http://togogenome.org/gene/9597:DDX1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZXC2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DDX1 subfamily.|||Cytoplasmic granule|||RNA helicase.|||The helicase domain is involved in the stimulation of RELA transcriptional activity. http://togogenome.org/gene/9597:CDK2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B4E4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:ORC5 ^@ http://purl.uniprot.org/uniprot/A0A2R9C1S3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:TMEM208 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZ40 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM208 family.|||Endoplasmic reticulum membrane|||May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.|||Membrane http://togogenome.org/gene/9597:NIPBL ^@ http://purl.uniprot.org/uniprot/A0A2R9BVJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCC2/Nipped-B family.|||Nucleus http://togogenome.org/gene/9597:SLC7A4 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9F8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:GPR12 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:ALDH1L1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AW45 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family.|||In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.|||In the N-terminal section; belongs to the GART family. http://togogenome.org/gene/9597:TRAPPC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9B1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/9597:NUP35 ^@ http://purl.uniprot.org/uniprot/A0A2R9BBH7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Nup35 family.|||Functions as a component of the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/9597:LOC103787041 ^@ http://purl.uniprot.org/uniprot/A0A2R9BL81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX16 family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9597:GPR158 ^@ http://purl.uniprot.org/uniprot/A0A2R9AC25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9597:TIGD3 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6K9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:MRPL17 ^@ http://purl.uniprot.org/uniprot/A0A2R9BT89 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL17 family. http://togogenome.org/gene/9597:TINAGL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BGQ9 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/9597:ADAMTS14 ^@ http://purl.uniprot.org/uniprot/A0A2R9A0L5 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9597:EXOC8 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9T0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EXO84 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.|||growth cone|||perinuclear region http://togogenome.org/gene/9597:CLDN25 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9P4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9597:XPNPEP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUH3 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/9597:PPP2R5B ^@ http://purl.uniprot.org/uniprot/A0A2R9AP80 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9597:LOC100986527 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/9597:RPN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C2J7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SWP1 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/9597:PI4KB ^@ http://purl.uniprot.org/uniprot/A0A2R9BCM6 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9597:FERMT1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHS3 ^@ Similarity ^@ Belongs to the kindlin family. http://togogenome.org/gene/9597:RAMAC ^@ http://purl.uniprot.org/uniprot/A0A2R9CM02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAM family.|||Nucleus http://togogenome.org/gene/9597:ZNF529 ^@ http://purl.uniprot.org/uniprot/A0A2R9C1J6 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:CCNC ^@ http://purl.uniprot.org/uniprot/A0A2R9A663 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9597:NDUFA7 ^@ http://purl.uniprot.org/uniprot/A0A2R9CL51 ^@ Function|||Similarity|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA7 subunit family.|||Complex I is composed of 45 different subunits. http://togogenome.org/gene/9597:AP5M1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CB95 ^@ Subcellular Location Annotation|||Subunit ^@ Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane|||Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1. http://togogenome.org/gene/9597:SLC35E4 ^@ http://purl.uniprot.org/uniprot/A0A2R9ANN3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:RUNX1 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7Z3 ^@ Function|||Subcellular Location Annotation ^@ Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.|||Nucleus http://togogenome.org/gene/9597:OASL ^@ http://purl.uniprot.org/uniprot/A0A2R9B9Z2|||http://purl.uniprot.org/uniprot/A0A2R9BFY8 ^@ Similarity ^@ Belongs to the 2-5A synthase family. http://togogenome.org/gene/9597:OCA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BE00 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:SESN3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/9597:POLM ^@ http://purl.uniprot.org/uniprot/A0A2R9BRU2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ).|||Nucleus http://togogenome.org/gene/9597:LOC100980585 ^@ http://purl.uniprot.org/uniprot/A0A2R9BHL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYBC1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:DRD1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZF27 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.|||Membrane|||dendritic spine http://togogenome.org/gene/9597:ACTR8 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACB9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the actin family. ARP8 subfamily.|||Chromosome|||Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core.|||Nucleus|||Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.|||Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. http://togogenome.org/gene/9597:CDCA8 ^@ http://purl.uniprot.org/uniprot/A0A2R9AEW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the borealin family.|||centromere http://togogenome.org/gene/9597:SHCBP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C6W8 ^@ Subcellular Location Annotation ^@ spindle http://togogenome.org/gene/9597:OR7D4 ^@ http://purl.uniprot.org/uniprot/D1MFA4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:ZNF793 ^@ http://purl.uniprot.org/uniprot/A0A2R9BMP2 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:DENND6A ^@ http://purl.uniprot.org/uniprot/A0A2R9AW14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DENND6 family.|||Recycling endosome http://togogenome.org/gene/9597:GPR68 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z941 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9597:ECSIT ^@ http://purl.uniprot.org/uniprot/A0A2R9BGV4|||http://purl.uniprot.org/uniprot/A0A2R9BHU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.|||Belongs to the ECSIT family.|||Cytoplasm|||Mitochondrion|||Nucleus http://togogenome.org/gene/9597:GLIPR1L1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZWZ4 ^@ Similarity ^@ Belongs to the CRISP family. http://togogenome.org/gene/9597:EFNA1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSH1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:FAM133B ^@ http://purl.uniprot.org/uniprot/A0A2R9BKK1 ^@ Similarity ^@ Belongs to the FAM133 family. http://togogenome.org/gene/9597:SMARCAL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CF28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.|||Nucleus http://togogenome.org/gene/9597:MAPT ^@ http://purl.uniprot.org/uniprot/A0A2R8Z985|||http://purl.uniprot.org/uniprot/A0A2R8Z9J4|||http://purl.uniprot.org/uniprot/A0A2R8ZFY4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||axon|||cytoskeleton|||cytosol|||dendrite http://togogenome.org/gene/9597:SLC25A19 ^@ http://purl.uniprot.org/uniprot/A0A2R9BB71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9597:MYLK2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C2Z8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.|||Cytoplasm|||May interact with centrin. http://togogenome.org/gene/9597:PDE2A ^@ http://purl.uniprot.org/uniprot/A0A2R9BH84|||http://purl.uniprot.org/uniprot/A0A2R9BH94 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9597:LOC103785057 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZM75 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/9597:LIG4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent DNA ligase family.|||Nucleus http://togogenome.org/gene/9597:COQ7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BAP6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ7 family.|||Binds 2 iron ions per subunit.|||Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:VANGL2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Vang family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:DMRT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BLJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/9597:SIN3A ^@ http://purl.uniprot.org/uniprot/A0A2R9AMN1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:PPP1R2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CKM6 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 2 family. http://togogenome.org/gene/9597:BMP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/9597:TACC3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4N6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACC family.|||centrosome http://togogenome.org/gene/9597:MPV17 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZ76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/9597:MIOS ^@ http://purl.uniprot.org/uniprot/A0A2R8ZY77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat mio family.|||Lysosome membrane http://togogenome.org/gene/9597:SETDB2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BX57|||http://purl.uniprot.org/uniprot/A0A2R9BZX0 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/9597:TCIRG1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9H4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/9597:PPP6C ^@ http://purl.uniprot.org/uniprot/A0A2R8Z8V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/9597:DDC ^@ http://purl.uniprot.org/uniprot/A0A2R9A9P2 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9597:CDC20 ^@ http://purl.uniprot.org/uniprot/A0A2R9AFL6 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/9597:RPS16 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPD1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/9597:LOC100968476 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z8M8 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:TESMIN ^@ http://purl.uniprot.org/uniprot/A0A2R9CCT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-54 family.|||Nucleus http://togogenome.org/gene/9597:NCL ^@ http://purl.uniprot.org/uniprot/A0A2R8ZC94 ^@ Function|||Subcellular Location Annotation ^@ Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.|||nucleolus http://togogenome.org/gene/9597:ERLIN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B717 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the band 7/mec-2 family.|||Endoplasmic reticulum membrane|||Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.|||Membrane http://togogenome.org/gene/9597:UPP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZ43 ^@ Function|||Similarity ^@ Belongs to the PNP/UDP phosphorylase family.|||Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. http://togogenome.org/gene/9597:CFAP96 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZN92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP96 family.|||centrosome http://togogenome.org/gene/9597:S100A2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B689 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9597:YJU2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZE51 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CWC16 family. YJU2 subfamily.|||Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.|||Nucleus|||Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex. http://togogenome.org/gene/9597:ZNF662 ^@ http://purl.uniprot.org/uniprot/A0A2R9CB85 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:PLBD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AF34 ^@ Function|||Similarity ^@ Belongs to the phospholipase B-like family.|||Putative phospholipase. http://togogenome.org/gene/9597:SART1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNU66/SART1 family.|||Nucleus http://togogenome.org/gene/9597:TTC27 ^@ http://purl.uniprot.org/uniprot/A0A2R9A5I4 ^@ Similarity ^@ Belongs to the TTC27 family. http://togogenome.org/gene/9597:ITGA10 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9597:ADPRM ^@ http://purl.uniprot.org/uniprot/A0A2R9CFU8 ^@ Similarity|||Subunit ^@ Belongs to the ADPRibase-Mn family.|||Monomer. http://togogenome.org/gene/9597:RPS25 ^@ http://purl.uniprot.org/uniprot/A0A2R9A563 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS25 family.|||Component of the small ribosomal subunit. http://togogenome.org/gene/9597:MRPL46 ^@ http://purl.uniprot.org/uniprot/A0A2R9C178 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL46 family.|||Mitochondrion http://togogenome.org/gene/9597:RPL26L1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A6V7|||http://purl.uniprot.org/uniprot/A0A2R9A6W8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/9597:ZDHHC9 ^@ http://purl.uniprot.org/uniprot/A0A2R9BRD8 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9597:DPPA2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZXS6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:LOC100981207 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGN9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:TAGLN3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSF0 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/9597:CX3CL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJ74 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9597:PIGW ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPP6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGW family.|||Endoplasmic reticulum membrane|||Membrane|||Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. http://togogenome.org/gene/9597:PLPP4 ^@ http://purl.uniprot.org/uniprot/A0A2R9C2Y2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9597:ASB16 ^@ http://purl.uniprot.org/uniprot/A0A2R9ARQ9 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9597:ACTR6 ^@ http://purl.uniprot.org/uniprot/A0A2R9B3B3 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9597:MOB1B ^@ http://purl.uniprot.org/uniprot/A0A2R9ARS9|||http://purl.uniprot.org/uniprot/A0A2R9AYC4 ^@ Similarity ^@ Belongs to the MOB1/phocein family. http://togogenome.org/gene/9597:GUCY1B1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Cytoplasm http://togogenome.org/gene/9597:RAD23B ^@ http://purl.uniprot.org/uniprot/A0A2R9C4U2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAD23 family.|||Cytoplasm|||Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.|||Nucleus http://togogenome.org/gene/9597:AVPR1A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZWK4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane|||Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. http://togogenome.org/gene/9597:N4BP3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the N4BP3 family.|||Vesicle|||dendrite http://togogenome.org/gene/9597:LOC100982452 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVS6 ^@ Similarity ^@ Belongs to the apolipoprotein L family. http://togogenome.org/gene/9597:B3GALNT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B8J8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:RNH1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9W9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.|||Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis. http://togogenome.org/gene/9597:TACC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BPI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACC family.|||centrosome http://togogenome.org/gene/9597:HOXC13 ^@ http://purl.uniprot.org/uniprot/A0A2R9B6H9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9597:NDUFA5 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJK0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA5 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:CCL20 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9597:RIF1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPE7 ^@ Subcellular Location Annotation ^@ Nucleus|||telomere http://togogenome.org/gene/9597:MED21 ^@ http://purl.uniprot.org/uniprot/A0A2R9AF15 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 21 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9597:ZNF285 ^@ http://purl.uniprot.org/uniprot/A0A2R9APL1 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:LOC100983382 ^@ http://purl.uniprot.org/uniprot/A0A2R9APA0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:ZNF785 ^@ http://purl.uniprot.org/uniprot/A0A2R9CSC7 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:MRTO4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CMN3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the pre-60S ribosomal particle.|||Belongs to the universal ribosomal protein uL10 family.|||Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.|||Cytoplasm|||nucleolus http://togogenome.org/gene/9597:NGDN ^@ http://purl.uniprot.org/uniprot/A0A2R9BWW2 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9597:DKKL1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYM3 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9597:PLA2G2F ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZ19 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9597:SPOP ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tdpoz family.|||Nucleus speckle http://togogenome.org/gene/9597:RBP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9APR6 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9597:DSC3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C429 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.|||Membrane|||desmosome http://togogenome.org/gene/9597:HK3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BGC9 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/9597:MAGT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BIT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:LOC100992144 ^@ http://purl.uniprot.org/uniprot/A0A2R9B285 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9597:CLEC12B ^@ http://purl.uniprot.org/uniprot/A0A2R9AB46 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:CTSS ^@ http://purl.uniprot.org/uniprot/A0A2R9ABI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9597:FSHB ^@ http://purl.uniprot.org/uniprot/A0A2R9BQ30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/9597:BUD23 ^@ http://purl.uniprot.org/uniprot/A0A2R9CE06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:ACTMAP ^@ http://purl.uniprot.org/uniprot/A0A2R9AIA6 ^@ Similarity ^@ Belongs to the ACTMAP family. http://togogenome.org/gene/9597:TNFRSF1A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZK33 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:ST3GAL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5E6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9597:CELF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AVQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CELF/BRUNOL family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:LOX ^@ http://purl.uniprot.org/uniprot/A0A2R9B5X9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/9597:VPS35L ^@ http://purl.uniprot.org/uniprot/A0A2R9A304 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS35L family.|||Endosome http://togogenome.org/gene/9597:SH3BGRL ^@ http://purl.uniprot.org/uniprot/A0A2R9B7T7 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/9597:OTUB1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEY0 ^@ Similarity ^@ Belongs to the peptidase C65 family. http://togogenome.org/gene/9597:DAPK3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A7I4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:MOSPD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AHI8|||http://purl.uniprot.org/uniprot/A0A2R9AM97 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:HSD3B7 ^@ http://purl.uniprot.org/uniprot/A0A2R9A697 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9597:MDGA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BP11 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:LOC100989257 ^@ http://purl.uniprot.org/uniprot/A0A2R9BK82 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/9597:UBA7 ^@ http://purl.uniprot.org/uniprot/A0A2R9A4T3 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/9597:LOC100971944 ^@ http://purl.uniprot.org/uniprot/A0A2R9BQZ2 ^@ Similarity ^@ Belongs to the BCL7 family. http://togogenome.org/gene/9597:RAG2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZER4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAG2 family.|||Nucleus http://togogenome.org/gene/9597:AQP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B319 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9597:CD46 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZA38|||http://purl.uniprot.org/uniprot/A0A2R8ZGY4 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||acrosome inner membrane http://togogenome.org/gene/9597:TMEM86B ^@ http://purl.uniprot.org/uniprot/A0A2R9A1I0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM86 family.|||Membrane http://togogenome.org/gene/9597:VAX2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQQ8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:IDH3G ^@ http://purl.uniprot.org/uniprot/A0A2R9C9Y4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.|||Mitochondrion http://togogenome.org/gene/9597:GNPDA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BM67 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/9597:RPS6KA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C519|||http://purl.uniprot.org/uniprot/A0A2R9C536 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9597:PIR ^@ http://purl.uniprot.org/uniprot/A0A2R9A827 ^@ Similarity ^@ Belongs to the pirin family. http://togogenome.org/gene/9597:SOD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BMB0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems.|||Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.|||Homotetramer.|||Mitochondrion matrix http://togogenome.org/gene/9597:KDELR3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AB20 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:EIF5A2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BAY0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Endoplasmic reticulum membrane|||Membrane|||Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.|||eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group. http://togogenome.org/gene/9597:DDOST ^@ http://purl.uniprot.org/uniprot/A0A2R9BPC0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DDOST 48 kDa subunit family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). http://togogenome.org/gene/9597:LOC100979289 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGW2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9597:FTSJ1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A0A8|||http://purl.uniprot.org/uniprot/A0A2R9A1G8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.|||Cytoplasm|||Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. http://togogenome.org/gene/9597:USP26 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZF88 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9597:PCYOX1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BF23 ^@ Similarity ^@ Belongs to the prenylcysteine oxidase family. http://togogenome.org/gene/9597:PITX2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CCR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9597:PNPLA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A7L4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:VAC14 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZXL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VAC14 family.|||Endosome membrane|||Microsome membrane http://togogenome.org/gene/9597:LOC100979818 ^@ http://purl.uniprot.org/uniprot/A0A2R9CML0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/9597:PRPF38A ^@ http://purl.uniprot.org/uniprot/A0A2R9AIU8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PRP38 family.|||Component of the spliceosome B complex.|||Involved in pre-mRNA splicing as a component of the spliceosome.|||Nucleus http://togogenome.org/gene/9597:LOC100973935 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIK1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:SLCO5A1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIK4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:TCTN2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZT19 ^@ Similarity|||Subunit ^@ Belongs to the tectonic family.|||Part of the tectonic-like complex (also named B9 complex). http://togogenome.org/gene/9597:HTATSF1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZM86 ^@ Similarity ^@ Belongs to the HTATSF1 family. http://togogenome.org/gene/9597:CCL18 ^@ http://purl.uniprot.org/uniprot/A0A2R9BML7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9597:PKLR ^@ http://purl.uniprot.org/uniprot/A0A2R9C0K5 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/9597:FLNC ^@ http://purl.uniprot.org/uniprot/A0A2R9B668|||http://purl.uniprot.org/uniprot/A0A2R9BDB4 ^@ Similarity ^@ Belongs to the filamin family. http://togogenome.org/gene/9597:ATP5MF ^@ http://purl.uniprot.org/uniprot/A0A2R9BDW8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase F chain family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:BOLA1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNI9 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/9597:PIAS3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AN48 ^@ Similarity ^@ Belongs to the PIAS family. http://togogenome.org/gene/9597:LEFTY2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9G4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/9597:CDK14 ^@ http://purl.uniprot.org/uniprot/A0A2R9CE45|||http://purl.uniprot.org/uniprot/A0A2R9CEA5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:TOM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BZ40 ^@ Similarity ^@ Belongs to the TOM1 family. http://togogenome.org/gene/9597:STN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AF72 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the STN1 family.|||Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.|||Component of the CST complex.|||Nucleus|||telomere http://togogenome.org/gene/9597:FAM229A ^@ http://purl.uniprot.org/uniprot/A0A2R9ARW7 ^@ Similarity ^@ Belongs to the FAM229 family. http://togogenome.org/gene/9597:LOC100993591 ^@ http://purl.uniprot.org/uniprot/A0A2R9A341 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9597:FXYD2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPT9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FXYD family.|||May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.|||Membrane|||Regulatory subunit of the sodium/potassium-transporting ATPase which is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. http://togogenome.org/gene/9597:IREB2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BR28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Cytoplasm http://togogenome.org/gene/9597:SLC16A7 ^@ http://purl.uniprot.org/uniprot/A0A2R9B438 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/9597:CDSN ^@ http://purl.uniprot.org/uniprot/A0A2R8ZXM2 ^@ Function|||Subcellular Location Annotation ^@ Important for the epidermal barrier integrity.|||Secreted http://togogenome.org/gene/9597:CALHM2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AEK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9597:RPL18A ^@ http://purl.uniprot.org/uniprot/A0A2R9BAC1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL20 family. http://togogenome.org/gene/9597:MMP7 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZJ1 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9597:ZNF619 ^@ http://purl.uniprot.org/uniprot/A0A2R9B7B8 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:DGKG ^@ http://purl.uniprot.org/uniprot/A0A2R9AY61|||http://purl.uniprot.org/uniprot/A0A2R9B257 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/9597:EIF3D ^@ http://purl.uniprot.org/uniprot/A0A2R9AH19 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit D family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Cytoplasm|||Phosphorylated upon DNA damage, probably by ATM or ATR.|||The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.|||mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs. http://togogenome.org/gene/9597:STX7 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQ90 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9597:CALHM4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZL72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9597:NNMT ^@ http://purl.uniprot.org/uniprot/A0A2R9A3D6 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. http://togogenome.org/gene/9597:AK8 ^@ http://purl.uniprot.org/uniprot/A0A2R9B4R4 ^@ Similarity ^@ Belongs to the adenylate kinase family. http://togogenome.org/gene/9597:LOC100989288 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIH0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:TRAPPC3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CEI6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||Homodimer.|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||cis-Golgi network http://togogenome.org/gene/9597:MYRF ^@ http://purl.uniprot.org/uniprot/A0A2R9API6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRF family.|||Membrane http://togogenome.org/gene/9597:DCTN5 ^@ http://purl.uniprot.org/uniprot/A0A2R9AFU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.|||cytoskeleton http://togogenome.org/gene/9597:EEF1G ^@ http://purl.uniprot.org/uniprot/A0A2R9CLP5 ^@ Function|||Subunit ^@ EF-1 is composed of four subunits: alpha, beta, delta, and gamma.|||Probably plays a role in anchoring the complex to other cellular components. http://togogenome.org/gene/9597:PEMT ^@ http://purl.uniprot.org/uniprot/A0A2R8Z718 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.|||Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9597:DOLPP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BRC9|||http://purl.uniprot.org/uniprot/A0A2R9BUU0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dolichyldiphosphatase family.|||Endoplasmic reticulum membrane|||Membrane|||Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate. http://togogenome.org/gene/9597:IQCG ^@ http://purl.uniprot.org/uniprot/A0A2R9AK59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC9 family.|||flagellum|||flagellum axoneme http://togogenome.org/gene/9597:MOS ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJ46 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:E2F6 ^@ http://purl.uniprot.org/uniprot/A0A2R9BBC3|||http://purl.uniprot.org/uniprot/A0A2R9BCQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9597:TNP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear transition protein 1 family.|||Chromosome|||Nucleus http://togogenome.org/gene/9597:GPM6B ^@ http://purl.uniprot.org/uniprot/A0A2R9BQI3|||http://purl.uniprot.org/uniprot/A0A2R9BQI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/9597:LGMN ^@ http://purl.uniprot.org/uniprot/A0A2R9BQF5 ^@ Similarity ^@ Belongs to the peptidase C13 family. http://togogenome.org/gene/9597:TIPARP ^@ http://purl.uniprot.org/uniprot/A0A2R9A755 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9597:CLDN18 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z890 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9597:YIPF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B953 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Endosome membrane|||Golgi apparatus membrane|||Late endosome membrane|||Membrane|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/9597:ZNF891 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7T5 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:TFCP2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus http://togogenome.org/gene/9597:TRIM46 ^@ http://purl.uniprot.org/uniprot/A0A2R9A2Q7|||http://purl.uniprot.org/uniprot/A0A2R9A7C6 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9597:TRABD2A ^@ http://purl.uniprot.org/uniprot/A0A2R9BW86|||http://purl.uniprot.org/uniprot/A0A2R9BW90|||http://purl.uniprot.org/uniprot/A0A2R9C5V8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TIKI family.|||Cell membrane|||Divalent metal cations. Mn(2+) or Co(2+).|||Membrane|||Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. http://togogenome.org/gene/9597:EXTL1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZH50|||http://purl.uniprot.org/uniprot/A0A2R8ZH51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:DDX55 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z8Y8 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9597:DLX5 ^@ http://purl.uniprot.org/uniprot/A0A2R9ALQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus http://togogenome.org/gene/9597:RPS29 ^@ http://purl.uniprot.org/uniprot/A0A2R9AK38|||http://purl.uniprot.org/uniprot/A0A2R9AS94 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Component of the 40S small ribosomal subunit. http://togogenome.org/gene/9597:BGLAP ^@ http://purl.uniprot.org/uniprot/A0A2R9CDC0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the osteocalcin/matrix Gla protein family.|||Binds strongly to apatite and calcium.|||Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.|||Secreted http://togogenome.org/gene/9597:LOC100986365 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIQ4 ^@ Similarity ^@ Belongs to the PRAME family. http://togogenome.org/gene/9597:STX1B ^@ http://purl.uniprot.org/uniprot/A0A2R9C7T7 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9597:CCDC25 ^@ http://purl.uniprot.org/uniprot/A0A2R9B6E7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CCDC25 family.|||Cell membrane|||Endomembrane system|||Interacts (via cytoplasmic region) with ILK. http://togogenome.org/gene/9597:PNLDC1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZR07 ^@ Similarity ^@ Belongs to the CAF1 family. http://togogenome.org/gene/9597:ARID5B ^@ http://purl.uniprot.org/uniprot/A0A2R9BMQ4|||http://purl.uniprot.org/uniprot/A0A2R9BWM5 ^@ Similarity ^@ Belongs to the ARID5B family. http://togogenome.org/gene/9597:RDM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9K3 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Homodimer.|||nucleolus http://togogenome.org/gene/9597:RRM2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7C5 ^@ Similarity ^@ Belongs to the ribonucleoside diphosphate reductase small chain family. http://togogenome.org/gene/9597:MT1X ^@ http://purl.uniprot.org/uniprot/A0A2R9CCW2 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9597:RPS6KB2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFT7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9597:ASPH ^@ http://purl.uniprot.org/uniprot/A0A2R9BAX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartyl/asparaginyl beta-hydroxylase family.|||Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/9597:CSF3R ^@ http://purl.uniprot.org/uniprot/A0A2R9BHK1|||http://purl.uniprot.org/uniprot/A0A2R9BQ68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/9597:FOLR3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CP43 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/9597:GRB2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A3I9 ^@ Subcellular Location Annotation ^@ Endosome|||Golgi apparatus|||Nucleus http://togogenome.org/gene/9597:TULP3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A7A1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TUB family.|||Secreted http://togogenome.org/gene/9597:PSMD8 ^@ http://purl.uniprot.org/uniprot/A0A2R9ATM2 ^@ Similarity ^@ Belongs to the proteasome subunit S14 family. http://togogenome.org/gene/9597:AGXT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B5M5 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9597:BTF3L4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPI0 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/9597:PMPCB ^@ http://purl.uniprot.org/uniprot/A0A2R9C334 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/9597:COMTD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A5Z9 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. http://togogenome.org/gene/9597:CHMP3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUG4 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9597:LOC100978953 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZA96 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9597:FBXO34 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNG7 ^@ Function ^@ Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. http://togogenome.org/gene/9597:TMEM170B ^@ http://purl.uniprot.org/uniprot/A0A2R9AXE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM170 family.|||Membrane http://togogenome.org/gene/9597:PRLHR ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDB9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9597:LOC100995944 ^@ http://purl.uniprot.org/uniprot/A0A2R9B4Y5 ^@ Similarity ^@ Belongs to the TACO1 family. http://togogenome.org/gene/9597:TMEM134 ^@ http://purl.uniprot.org/uniprot/A0A2R9BPB8|||http://purl.uniprot.org/uniprot/A0A2R9BYC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM134/TMEM230 family.|||Membrane http://togogenome.org/gene/9597:TGM5 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z5W5|||http://purl.uniprot.org/uniprot/A0A2R8Z9Q4 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9597:CYP4F8 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZP9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9597:TSHB ^@ http://purl.uniprot.org/uniprot/A0A2R9AHW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/9597:LOC100992178 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9M3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:GPR179 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9597:EDEM3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BPZ4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9597:UPF3B ^@ http://purl.uniprot.org/uniprot/A0A2R9BZN2|||http://purl.uniprot.org/uniprot/A0A2R9C080 ^@ Similarity ^@ Belongs to the RENT3 family. http://togogenome.org/gene/9597:MASTL ^@ http://purl.uniprot.org/uniprot/A0A2R9BTF3|||http://purl.uniprot.org/uniprot/A0A2R9BWV6 ^@ Subcellular Location Annotation ^@ Nucleus|||centrosome http://togogenome.org/gene/9597:RPRD1A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVE1|||http://purl.uniprot.org/uniprot/A0A2R8ZWL3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the RNA polymerase II complex.|||Belongs to the UPF0400 (RTT103) family.|||Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.|||Nucleus http://togogenome.org/gene/9597:PDCD4 ^@ http://purl.uniprot.org/uniprot/A0A2R9C3Z6 ^@ Similarity ^@ Belongs to the PDCD4 family. http://togogenome.org/gene/9597:DEUP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A7E8 ^@ Similarity ^@ Belongs to the CEP63 family. http://togogenome.org/gene/9597:CNTN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A0W3 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. Contactin family. http://togogenome.org/gene/9597:AURKA ^@ http://purl.uniprot.org/uniprot/A0A2R9ANX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.|||centrosome http://togogenome.org/gene/9597:SAMHD1 ^@ http://purl.uniprot.org/uniprot/H6WE98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAMHD1 family.|||Chromosome http://togogenome.org/gene/9597:BPNT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AC40 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/9597:SEMA4B ^@ http://purl.uniprot.org/uniprot/A0A2R9BXZ1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:LCAT ^@ http://purl.uniprot.org/uniprot/A0A2R9BD07 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9597:SLC9A8 ^@ http://purl.uniprot.org/uniprot/A0A2R9B3M6 ^@ Similarity ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. http://togogenome.org/gene/9597:GMPR2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BZM2|||http://purl.uniprot.org/uniprot/A0A2R9C072 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.|||Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:VXN ^@ http://purl.uniprot.org/uniprot/A0A2R9CDF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vexin family.|||Cell membrane|||Membrane|||Nucleus http://togogenome.org/gene/9597:LOC100995145 ^@ http://purl.uniprot.org/uniprot/A0A2R9B7Z2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cystatin family.|||Secreted http://togogenome.org/gene/9597:SLC15A2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BFL3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Interacts (via extracellular domain region) with trypsin.|||Membrane http://togogenome.org/gene/9597:KIT ^@ http://purl.uniprot.org/uniprot/A0A2R9AUT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:SFR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BFZ8|||http://purl.uniprot.org/uniprot/A0A2R9BJQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SFR1/MEI5 family.|||Nucleus http://togogenome.org/gene/9597:HOXA6 ^@ http://purl.uniprot.org/uniprot/A0A2R9BXR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9597:LAMTOR2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BH20|||http://purl.uniprot.org/uniprot/A0A2R9BQN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GAMAD family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/9597:PSMB7 ^@ http://purl.uniprot.org/uniprot/A0A2R9CID4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:DRD3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AV93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.|||Membrane http://togogenome.org/gene/9597:B3GAT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AKV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:FAM151B ^@ http://purl.uniprot.org/uniprot/A0A2R9BT92 ^@ Similarity ^@ Belongs to the FAM151 family. http://togogenome.org/gene/9597:POFUT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BCL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 65 family.|||Endoplasmic reticulum http://togogenome.org/gene/9597:MEIS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BFH6|||http://purl.uniprot.org/uniprot/A0A2R9BFJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/9597:TRAPPC4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BV14 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/9597:INPP4B ^@ http://purl.uniprot.org/uniprot/A0A2R9CP85 ^@ Similarity ^@ Belongs to the inositol 3,4-bisphosphate 4-phosphatase family. http://togogenome.org/gene/9597:ZKSCAN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BHM6 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9597:CNIH1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AH71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/9597:TNNI3 ^@ http://purl.uniprot.org/uniprot/A0A2R9ATT7 ^@ Function|||Similarity ^@ Belongs to the troponin I family.|||Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. http://togogenome.org/gene/9597:TPM4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYH4|||http://purl.uniprot.org/uniprot/A0A2R9BZ22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9597:DCK ^@ http://purl.uniprot.org/uniprot/A0A2R9BA40 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/9597:LOC100974743 ^@ http://purl.uniprot.org/uniprot/A0A2R9C869 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:SEPTIN12 ^@ http://purl.uniprot.org/uniprot/A0A2R9B1U5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9597:CFC1B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTX6 ^@ Caution|||Similarity ^@ Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:SDAD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSC6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SDA1 family.|||Required for 60S pre-ribosomal subunits export to the cytoplasm.|||nucleolus http://togogenome.org/gene/9597:EIF2B1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMT4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2B alpha/beta/delta subunits family.|||Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.|||Complex of five different subunits; alpha, beta, gamma, delta and epsilon. http://togogenome.org/gene/9597:RAB3A ^@ http://purl.uniprot.org/uniprot/A0A2R9A383 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/9597:MOSPD3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CHN6|||http://purl.uniprot.org/uniprot/A0A2R9CHS7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:ATP6V1B2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CR87 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits. http://togogenome.org/gene/9597:P2RX1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AHU8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9597:HBS1L ^@ http://purl.uniprot.org/uniprot/A0A2R9AE12|||http://purl.uniprot.org/uniprot/A0A2R9AE88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm http://togogenome.org/gene/9597:WNT10B ^@ http://purl.uniprot.org/uniprot/A0A2R9B5H3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9597:SYNGR3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CD99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptogyrin family.|||Membrane http://togogenome.org/gene/9597:MRGPRX2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJ26 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9597:MFSD9 ^@ http://purl.uniprot.org/uniprot/A0A2R9BZN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/9597:ACTN4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CB79 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/9597:TCAF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CGI0 ^@ Similarity ^@ Belongs to the TCAF family. http://togogenome.org/gene/9597:CYP1A2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZXU3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9597:SMDT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BBB3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMDT1/EMRE family.|||Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.|||Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9597:ACTR3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4Y1 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9597:MIX23 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZ87 ^@ Similarity ^@ Belongs to the MIX23 family. http://togogenome.org/gene/9597:GTF2H4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BWT9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB2 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.|||Nucleus http://togogenome.org/gene/9597:YIPF6 ^@ http://purl.uniprot.org/uniprot/A0A2R9CI42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:AHR ^@ http://purl.uniprot.org/uniprot/A0A2R9AFN6 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9597:TTC4 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9P0 ^@ Similarity ^@ Belongs to the TTC4 family. http://togogenome.org/gene/9597:ZNF197 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEJ1 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9597:ING3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A2Z0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9597:ST6GALNAC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9APX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9597:CGA ^@ http://purl.uniprot.org/uniprot/A0A2R9A0T2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit alpha family.|||Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.|||Secreted http://togogenome.org/gene/9597:EHD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BNU0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/9597:ZNF165 ^@ http://purl.uniprot.org/uniprot/A0A2R9ASP6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:DHRS11 ^@ http://purl.uniprot.org/uniprot/A0A2R9AKF4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9597:ARR3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A5X7 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9597:PRF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5V2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Secreted http://togogenome.org/gene/9597:SLC25A38 ^@ http://purl.uniprot.org/uniprot/A0A2R9AHF2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.|||Membrane|||Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.|||Mitochondrion inner membrane|||Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis. http://togogenome.org/gene/9597:LOC100976806 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBD4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:LOC100987685 ^@ http://purl.uniprot.org/uniprot/A0A2R9B108 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:STX17 ^@ http://purl.uniprot.org/uniprot/A0A2R9BBS0 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9597:MYOD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BB02 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.|||Nucleus http://togogenome.org/gene/9597:TMEM63B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZS96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/9597:SOSTDC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B357 ^@ Caution|||Similarity ^@ Belongs to the sclerostin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:SLC16A9 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:PER2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CHZ7 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9597:DUSP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A4E5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/9597:MRPL58 ^@ http://purl.uniprot.org/uniprot/A0A2R9AR27 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9597:MYO9A ^@ http://purl.uniprot.org/uniprot/A0A2R9BBY5 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9597:PDIK1L ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKW0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:ALG5 ^@ http://purl.uniprot.org/uniprot/A0A2R9BD74 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/9597:KCNA6 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAS1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:ST3GAL6 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6P2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9597:GPR33 ^@ http://purl.uniprot.org/uniprot/Q49SQ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Orphan receptor; could be a chemoattractant receptor. http://togogenome.org/gene/9597:NIPAL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AIH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9597:NR1H2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZW74|||http://purl.uniprot.org/uniprot/A0A2R8ZW79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9597:PSENEN ^@ http://purl.uniprot.org/uniprot/A0A2R9APY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PEN-2 family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9597:CLCA4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AF53 ^@ Similarity ^@ Belongs to the CLCR family. http://togogenome.org/gene/9597:LOC100986336 ^@ http://purl.uniprot.org/uniprot/A0A2R9AR52|||http://purl.uniprot.org/uniprot/B3Y663 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.|||Endoplasmic reticulum membrane|||Lysosome|||Membrane|||cytoskeleton|||phagosome http://togogenome.org/gene/9597:RPS28 ^@ http://purl.uniprot.org/uniprot/A0A2R9A306 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/9597:CCL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ARC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9597:TUBB4B ^@ http://purl.uniprot.org/uniprot/A0A2R9AYQ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9597:NXPH1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B5L4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/9597:SOD1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYG2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Cu-Zn superoxide dismutase family.|||Binds 1 copper ion per subunit.|||Binds 1 zinc ion per subunit.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/9597:SSH2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ATJ6|||http://purl.uniprot.org/uniprot/A0A2R9AXS9 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. http://togogenome.org/gene/9597:CYP4V2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZRT4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9597:OPTC ^@ http://purl.uniprot.org/uniprot/A0A2R9CN77 ^@ Similarity ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. http://togogenome.org/gene/9597:ACTN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BFF0|||http://purl.uniprot.org/uniprot/A0A2R9BFF6|||http://purl.uniprot.org/uniprot/A0A2R9BFG1 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/9597:SIRT5 ^@ http://purl.uniprot.org/uniprot/A0A2R9AH39 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sirtuin family. Class III subfamily.|||Binds 1 zinc ion per subunit.|||In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-102 and Arg-105) that bind to malonylated and succinylated substrates and define the specificity.|||Mitochondrion|||Monomer. Homodimer. Interacts with CPS1.|||NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as Uox.|||Nucleus|||cytosol http://togogenome.org/gene/9597:IL1R1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BU72 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9597:NCAPH ^@ http://purl.uniprot.org/uniprot/A0A2R9BZS9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CND2 (condensin subunit 2) family.|||Chromosome|||Cytoplasm|||Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. http://togogenome.org/gene/9597:DDX31 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZX27 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9597:NDNF ^@ http://purl.uniprot.org/uniprot/A0A2R8ZI86 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9597:MZF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACI4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:ARL4C ^@ http://purl.uniprot.org/uniprot/A0A2R8ZD81 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9597:CEP162 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP162 family.|||centriole http://togogenome.org/gene/9597:TMEM167B ^@ http://purl.uniprot.org/uniprot/A0A2R9BKL3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KISH family.|||Golgi apparatus membrane|||Involved in the early part of the secretory pathway.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:CCDC90B ^@ http://purl.uniprot.org/uniprot/A0A2R9AN53 ^@ Similarity ^@ Belongs to the CCDC90 family. http://togogenome.org/gene/9597:IL9 ^@ http://purl.uniprot.org/uniprot/A0A2R9ANX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-7/IL-9 family.|||Secreted http://togogenome.org/gene/9597:ALDH1A3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDK5|||http://purl.uniprot.org/uniprot/A0A2R9CLP3 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9597:SNRNP27 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSD6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNUT3 family.|||May play a role in mRNA splicing.|||Nucleus|||Part of a tri-snRNP complex. http://togogenome.org/gene/9597:ITPA ^@ http://purl.uniprot.org/uniprot/A0A2R9B6B8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Cytoplasm|||Homodimer.|||Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. http://togogenome.org/gene/9597:IFT20 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZB42 ^@ Subcellular Location Annotation ^@ centriole|||cilium|||cis-Golgi network http://togogenome.org/gene/9597:LOC100986398 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLY5|||http://purl.uniprot.org/uniprot/A0A4Y1JWN7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9597:IRF5 ^@ http://purl.uniprot.org/uniprot/A0A2R9AHU1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:SLC26A8 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/9597:DYNLT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AIG3 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/9597:OTC ^@ http://purl.uniprot.org/uniprot/A0A2R9AD21 ^@ Similarity|||Subunit ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily.|||Homotrimer. http://togogenome.org/gene/9597:HSD17B10 ^@ http://purl.uniprot.org/uniprot/A0A2R9ANQ0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9597:TES ^@ http://purl.uniprot.org/uniprot/A0A2R9B209 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prickle / espinas / testin family.|||Cytoplasm|||focal adhesion http://togogenome.org/gene/9597:ZBTB8OS ^@ http://purl.uniprot.org/uniprot/A0A2R9A793 ^@ Similarity|||Subunit ^@ Belongs to the archease family.|||Component of the tRNA-splicing ligase complex. http://togogenome.org/gene/9597:GET1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B4A2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WRB/GET1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:UTP23 ^@ http://purl.uniprot.org/uniprot/A0A2R9A225 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9597:EMC4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AL49|||http://purl.uniprot.org/uniprot/A0A2R9AL61 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC4 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:CLDN9 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZF85 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9597:CHPF2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9597:EFNB3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZZ1 ^@ Caution|||Similarity ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:AZIN1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZXZ8 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/9597:LOC100984204 ^@ http://purl.uniprot.org/uniprot/A0A2R9B4W3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9597:GABRA6 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQ75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9597:RNF146 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPI6 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Can form homooligomers. Interacts with PARsylated AXIN1, AXIN2, BLZF1, CASC3, H1-2, IPO7, LIG3, NCL, PARP1, XRCC1, XRCC5 and XRCC6. Interacts with DDB1, DHX15, IQGAP1, LRPPRC, PARP2, PRKDC, RUVBL2, TNKS1 and TNKS2. Binding often leads to interactor ubiquitination, in the presence of the appropriate E1 and E2 enzymes, and proteasomal degradation.|||E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.|||The WWE domain mediates non-covalent poly(ADP-ribose)-binding.|||Ubiquitinated; autoubiquitinated.|||cytosol http://togogenome.org/gene/9597:DAP3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AE81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS29 family.|||Mitochondrion http://togogenome.org/gene/9597:FAM174B ^@ http://purl.uniprot.org/uniprot/A0A2R9B0I2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM174 family.|||Membrane http://togogenome.org/gene/9597:SLC26A7 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/9597:MRPS24 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZ51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS3 family.|||Mitochondrion http://togogenome.org/gene/9597:LPCAT4 ^@ http://purl.uniprot.org/uniprot/A0A2R9B1Q1 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9597:HAPLN3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B9J9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:LOC100986914 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJK5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the p22phox family.|||Cell membrane|||Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).|||Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.|||Membrane http://togogenome.org/gene/9597:ZSCAN9 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZM80 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:CYP51A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C313 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9597:RPS4X ^@ http://purl.uniprot.org/uniprot/A0A2R9C5L1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/9597:DPH5 ^@ http://purl.uniprot.org/uniprot/A0A2R9AF90 ^@ Function|||Similarity ^@ Belongs to the diphthine synthase family.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/9597:TRRAP ^@ http://purl.uniprot.org/uniprot/A0A2R9BFY1 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. TRA1 subfamily. http://togogenome.org/gene/9597:TMEM254 ^@ http://purl.uniprot.org/uniprot/A0A2R9BKD0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:LOC103785151 ^@ http://purl.uniprot.org/uniprot/A0A2R9AF17 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/9597:SHMT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9P3|||http://purl.uniprot.org/uniprot/A0A2R9ADM5 ^@ Function|||Similarity ^@ Belongs to the SHMT family.|||Interconversion of serine and glycine. http://togogenome.org/gene/9597:STEAP2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9597:SCNN1B ^@ http://purl.uniprot.org/uniprot/A0A2R9B176 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:RBM10 ^@ http://purl.uniprot.org/uniprot/A0A2R9C265 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:FCER1G ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQ97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD3Z/FCER1G family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:SCTR ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBW6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:MCHR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AFP0 ^@ Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Interacts with NCDN.|||Membrane http://togogenome.org/gene/9597:EVL ^@ http://purl.uniprot.org/uniprot/A0A2R9AR90 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Ena/VASP family.|||Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.|||cytoskeleton http://togogenome.org/gene/9597:B3GNT3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:SUSD3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BM86|||http://purl.uniprot.org/uniprot/A0A2R9BSF1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:TMEM123 ^@ http://purl.uniprot.org/uniprot/A0A2R9CBF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD164 family.|||Membrane http://togogenome.org/gene/9597:RDH12 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7Y4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9597:SLC16A5 ^@ http://purl.uniprot.org/uniprot/A0A2R9AGP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/9597:OXCT1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZA36 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 3-oxoacid CoA-transferase family.|||Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.|||Mitochondrion http://togogenome.org/gene/9597:PARP14 ^@ http://purl.uniprot.org/uniprot/A0A2R9BZN9 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9597:NOL12 ^@ http://purl.uniprot.org/uniprot/A0A2R9AMS3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRP17 family.|||Interacts with KIAA1191.|||nucleolus http://togogenome.org/gene/9597:TRUB2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CGK9 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/9597:PTGDR ^@ http://purl.uniprot.org/uniprot/A0A2R9BPP7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:GAPDH ^@ http://purl.uniprot.org/uniprot/A0A2R9BWP9 ^@ Similarity|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/9597:MAMDC4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJX2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:EFEMP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AUY9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:ATF7IP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCAF family.|||Nucleus http://togogenome.org/gene/9597:LOC100985390 ^@ http://purl.uniprot.org/uniprot/A0A2R9AKG4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:APOO ^@ http://purl.uniprot.org/uniprot/A0A2R9AXK3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:TGIF2LX ^@ http://purl.uniprot.org/uniprot/A1YGI6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/TGIF homeobox family.|||May have a transcription role in testis.|||Nucleus http://togogenome.org/gene/9597:REEP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AKI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/9597:FGF13 ^@ http://purl.uniprot.org/uniprot/A0A2R9BAH5 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9597:DNAAF3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AKX4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNAAF3 family.|||Cytoplasm|||Dynein axonemal particle|||Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia. http://togogenome.org/gene/9597:PABPC4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJF4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyadenylate-binding protein type-1 family.|||Binds the poly(A) tail of mRNA.|||Cytoplasm http://togogenome.org/gene/9597:DNASE1L3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDX2 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/9597:SLC41A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AW46 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/9597:HHIP ^@ http://purl.uniprot.org/uniprot/A0A2R9AW72 ^@ Caution|||Similarity ^@ Belongs to the HHIP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:SRMS ^@ http://purl.uniprot.org/uniprot/A0A2R9ANH4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9597:LPCAT3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BH33 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:GORASP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9APA5 ^@ Similarity ^@ Belongs to the GORASP family. http://togogenome.org/gene/9597:NEURL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BZQ0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:SLC2A4 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z846 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Endomembrane system|||Membrane|||perinuclear region http://togogenome.org/gene/9597:NMI ^@ http://purl.uniprot.org/uniprot/A0A2R9B1A6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NMI family.|||Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/9597:LOC100979614 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNV6 ^@ Similarity ^@ Belongs to the pro/parathymosin family. http://togogenome.org/gene/9597:MMGT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AT41 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane magnesium transporter (TC 1.A.67) family.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport. http://togogenome.org/gene/9597:KCNH5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTW0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:BEST3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B2X5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms calcium-sensitive chloride channels. Permeable to bicarbonate.|||Membrane http://togogenome.org/gene/9597:LOC100988353 ^@ http://purl.uniprot.org/uniprot/A0A2R9A2N3 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/9597:MRPS16 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAM2 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/9597:ZNF232 ^@ http://purl.uniprot.org/uniprot/A0A2R9BW24 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:FLVCR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BHV5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:HSPA14 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHF6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 70 family.|||Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.|||Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.|||cytosol http://togogenome.org/gene/9597:F8 ^@ http://purl.uniprot.org/uniprot/A0A2R9ATQ4 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/9597:A4GNT ^@ http://purl.uniprot.org/uniprot/A0A2R9B7L5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 32 family.|||Golgi apparatus membrane http://togogenome.org/gene/9597:FAM120B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIG7 ^@ Similarity ^@ Belongs to the constitutive coactivator of PPAR-gamma family. http://togogenome.org/gene/9597:PACSIN1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PACSIN family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||cytosol|||ruffle membrane|||synaptosome http://togogenome.org/gene/9597:DCT ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane http://togogenome.org/gene/9597:CEP43 ^@ http://purl.uniprot.org/uniprot/A0A2R9BS82|||http://purl.uniprot.org/uniprot/A0A2R9BVQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP43 family.|||centriole|||cilium basal body http://togogenome.org/gene/9597:NRM ^@ http://purl.uniprot.org/uniprot/A0A2R9C279|||http://purl.uniprot.org/uniprot/A0A2R9C2Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nurim family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/9597:RFLNA ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKB5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Refilin family.|||Interacts with FLNA and FLNB.|||cytoskeleton http://togogenome.org/gene/9597:LOC106634652 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6E0 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9597:DPYSL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B731|||http://purl.uniprot.org/uniprot/A0A2R9BAW2 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/9597:OCEL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AKJ9 ^@ Similarity ^@ Belongs to the ELL/occludin family. http://togogenome.org/gene/9597:AKR1C4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AMJ4 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9597:CCNA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BV77 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin AB subfamily. http://togogenome.org/gene/9597:RDH10 ^@ http://purl.uniprot.org/uniprot/A0A2R9C8G0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9597:MAN1B1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BVG2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9597:METTL6 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTN7|||http://purl.uniprot.org/uniprot/A0A2R9BTP2 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/9597:RAB39A ^@ http://purl.uniprot.org/uniprot/A0A2R9CHT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:LOC100989142 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJ97 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:MSH2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXQ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA mismatch repair MutS family.|||Component of the post-replicative DNA mismatch repair system (MMR).|||Nucleus http://togogenome.org/gene/9597:OSBPL9 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJS2 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9597:CHAC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A270 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.|||Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. http://togogenome.org/gene/9597:ZNF510 ^@ http://purl.uniprot.org/uniprot/A0A2R9BRL3 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:KCNS3 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z5X2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:DGAT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B9G0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Homodimer or homotetramer; both forms have similar enzymatic activities.|||Membrane http://togogenome.org/gene/9597:DSC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BCF9 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.|||Membrane|||desmosome http://togogenome.org/gene/9597:HAPLN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BLD6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:SMC4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CEX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family.|||Chromosome|||Nucleus http://togogenome.org/gene/9597:SV2C ^@ http://purl.uniprot.org/uniprot/A0A2R9CB55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/9597:ZAR1L ^@ http://purl.uniprot.org/uniprot/A0A2R9BCX2 ^@ Similarity|||Subunit ^@ Belongs to the ZAR1 family.|||Interacts with YBX2. http://togogenome.org/gene/9597:GABRB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4H8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9597:GABARAPL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ASH1 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9597:APMAP ^@ http://purl.uniprot.org/uniprot/A0A2R9BGH7 ^@ Similarity ^@ Belongs to the strictosidine synthase family. http://togogenome.org/gene/9597:GPHB5 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z911 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/9597:LOC100976125 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCH7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:AKAP8L ^@ http://purl.uniprot.org/uniprot/A0A2R9A7D9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AKAP95 family.|||Nucleus matrix http://togogenome.org/gene/9597:WNT3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BL18 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9597:L3MBTL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C1E1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Nucleus|||Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, BAT8 and YAF2.|||Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. http://togogenome.org/gene/9597:EBF1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COE family.|||Nucleus http://togogenome.org/gene/9597:AHSA1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMF0 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/9597:TNN ^@ http://purl.uniprot.org/uniprot/A0A2R9C535 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tenascin family.|||extracellular matrix http://togogenome.org/gene/9597:TDP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A582|||http://purl.uniprot.org/uniprot/A0A2R9AAI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosyl-DNA phosphodiesterase family.|||Nucleus http://togogenome.org/gene/9597:PRKAB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AUB1 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/9597:MELK ^@ http://purl.uniprot.org/uniprot/A0A2R9CMJ7|||http://purl.uniprot.org/uniprot/A0A2R9CML8|||http://purl.uniprot.org/uniprot/A0A2R9CPC5|||http://purl.uniprot.org/uniprot/A0A2R9CTN6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. http://togogenome.org/gene/9597:TDO2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQE8 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the tryptophan 2,3-dioxygenase family.|||Binds 1 heme group per subunit.|||Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.|||Homotetramer. Dimer of dimers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:KCNJ2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZA76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.|||Membrane http://togogenome.org/gene/9597:SEMA3B ^@ http://purl.uniprot.org/uniprot/A0A2R9CEH4 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:TMEM186 ^@ http://purl.uniprot.org/uniprot/A0A2R9BFM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM186 family.|||Membrane http://togogenome.org/gene/9597:GSTO2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AHG4 ^@ Function|||Similarity ^@ Belongs to the GST superfamily. Omega family.|||Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). http://togogenome.org/gene/9597:LOC100983651 ^@ http://purl.uniprot.org/uniprot/A0A2R9B5J2|||http://purl.uniprot.org/uniprot/A0A2R9BCL5 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:CLRN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CAI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/9597:NDUFS3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AFM3 ^@ Similarity ^@ Belongs to the complex I 30 kDa subunit family. http://togogenome.org/gene/9597:ACTL6B ^@ http://purl.uniprot.org/uniprot/A0A2R9B2N6 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9597:ACSF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CAF0 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9597:ORMDL3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BAU9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/9597:PPM1K ^@ http://purl.uniprot.org/uniprot/A0A2R9CCF4 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9597:MRPS11 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYN8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/9597:LSM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ARA3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Cytoplasm|||Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.|||P-body|||Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. http://togogenome.org/gene/9597:CLDN15 ^@ http://purl.uniprot.org/uniprot/A0A2R9B8A6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9597:HOXC8 ^@ http://purl.uniprot.org/uniprot/A0A2R9ASM5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:NDUFA6 ^@ http://purl.uniprot.org/uniprot/A0A2R9BP15 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I LYR family.|||Mammalian complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:PEX5 ^@ http://purl.uniprot.org/uniprot/A0A2R9C1R3|||http://purl.uniprot.org/uniprot/A0A2R9C299 ^@ Similarity ^@ Belongs to the peroxisomal targeting signal receptor family. http://togogenome.org/gene/9597:STX5 ^@ http://purl.uniprot.org/uniprot/A0A2R9BX41 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9597:ZNF768 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTQ1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:SLC6A2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJ86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9597:CAP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAP family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:ANKRD13C ^@ http://purl.uniprot.org/uniprot/A0A2R9B0Y8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:ABCD3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BW79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9597:NR5A2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BR60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR5 subfamily.|||Nucleus http://togogenome.org/gene/9597:MARF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C740 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/9597:LYPD5 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABL4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:PPP1R12B ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7L6|||http://purl.uniprot.org/uniprot/A0A2R8Z7M1 ^@ Subcellular Location Annotation|||Subunit ^@ PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.|||stress fiber http://togogenome.org/gene/9597:HEATR5B ^@ http://purl.uniprot.org/uniprot/A0A2R9C824 ^@ Similarity ^@ Belongs to the HEATR5 family. http://togogenome.org/gene/9597:LOC100977135 ^@ http://purl.uniprot.org/uniprot/A0A2R9AC19 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9597:GDF10 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5P7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer.|||Secreted http://togogenome.org/gene/9597:KIF24 ^@ http://purl.uniprot.org/uniprot/A0A2R9A000 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9597:NCDN ^@ http://purl.uniprot.org/uniprot/A0A2R9BZC2|||http://purl.uniprot.org/uniprot/A0A2R9C2I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the neurochondrin family.|||Postsynapse http://togogenome.org/gene/9597:ERN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AFY5 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:FOXI1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMY1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:ACADM ^@ http://purl.uniprot.org/uniprot/A0A2R9BBV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA dehydrogenase family.|||Mitochondrion matrix http://togogenome.org/gene/9597:RMND1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B6V6 ^@ Similarity ^@ Belongs to the RMD1/sif2 family. http://togogenome.org/gene/9597:CD14 ^@ http://purl.uniprot.org/uniprot/B3Y6B4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Interacts with LPAR1.|||Cell membrane|||Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).|||Golgi apparatus|||Membrane raft|||Secreted http://togogenome.org/gene/9597:LOC100987427 ^@ http://purl.uniprot.org/uniprot/A0A2R9A2Z2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCRQ/QCR8 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9597:LOC103785895 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQQ2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space|||Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. http://togogenome.org/gene/9597:ZNF548 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTA0 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:TYR ^@ http://purl.uniprot.org/uniprot/A0A2R9A709 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane http://togogenome.org/gene/9597:PAM ^@ http://purl.uniprot.org/uniprot/A0A2R9A3K2|||http://purl.uniprot.org/uniprot/A0A2R9A917 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Binds 2 Cu(2+) ions per subunit.|||Binds one Zn(2+) ion per subunit.|||In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.|||In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.|||Membrane|||secretory vesicle membrane http://togogenome.org/gene/9597:LOC100970874 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5I9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COA3 family.|||Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.|||Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.|||Membrane|||Required for assembly of cytochrome c oxidase (complex IV). http://togogenome.org/gene/9597:NETO1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPB0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:ACYP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZV40|||http://purl.uniprot.org/uniprot/A0A2R8ZX98 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/9597:BABAM2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BRV7|||http://purl.uniprot.org/uniprot/A0A2R9C0X7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BABAM2 family.|||Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.|||Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.|||Cytoplasm|||May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.|||Nucleus http://togogenome.org/gene/9597:SGTB ^@ http://purl.uniprot.org/uniprot/A0A2R9BWR2 ^@ Similarity ^@ Belongs to the SGT family. http://togogenome.org/gene/9597:SNRPD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BU17 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.|||cytosol http://togogenome.org/gene/9597:EGFL6 ^@ http://purl.uniprot.org/uniprot/A0A2R9A753 ^@ Caution|||Similarity ^@ Belongs to the nephronectin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:SHKBP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CLG4 ^@ Similarity ^@ Belongs to the KCTD3 family. http://togogenome.org/gene/9597:TIPIN ^@ http://purl.uniprot.org/uniprot/A0A2R9AZ91 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSM3 family.|||Nucleus|||Plays an important role in the control of DNA replication and the maintenance of replication fork stability. http://togogenome.org/gene/9597:CASP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AB18 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9597:SH3RF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CMR3 ^@ Similarity ^@ Belongs to the SH3RF family. http://togogenome.org/gene/9597:TMEM184C ^@ http://purl.uniprot.org/uniprot/A0A2R9AN83 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:SEMA4D ^@ http://purl.uniprot.org/uniprot/A0A2R8Z765 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:ABLIM2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B270 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:MSN ^@ http://purl.uniprot.org/uniprot/A0A2R9AZU4 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/9597:PAF1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZXI6 ^@ Similarity ^@ Belongs to the PAF1 family. http://togogenome.org/gene/9597:MMP3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BCT7 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9597:AGT ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSQ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the serpin family.|||Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.|||Secreted|||Stimulates aldosterone release. http://togogenome.org/gene/9597:ZFPL1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZI90 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ZFPL1 family.|||Interacts with GOLGA2/GM130.|||Membrane|||Required for cis-Golgi integrity and efficient ER to Golgi transport.|||The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.|||cis-Golgi network membrane http://togogenome.org/gene/9597:FAT4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AP84 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:LOC100969885 ^@ http://purl.uniprot.org/uniprot/A0A2R9CFS7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/9597:LOC100980944 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUW8 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9597:LOC103786029 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUE3 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9597:KCNJ15 ^@ http://purl.uniprot.org/uniprot/A0A2R9AKM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9597:EIF4A2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFC3 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family. eIF4A subfamily.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9597:GPBP1L1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BWN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vasculin family.|||Nucleus http://togogenome.org/gene/9597:TMEM14C ^@ http://purl.uniprot.org/uniprot/A0A2R9BX17 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/9597:EFNB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C3A4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:TRAK1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A2T9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the milton family.|||Early endosome|||Mitochondrion http://togogenome.org/gene/9597:CHGB ^@ http://purl.uniprot.org/uniprot/A0A2R9AN01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromogranin/secretogranin protein family.|||Secreted http://togogenome.org/gene/9597:MOCOS ^@ http://purl.uniprot.org/uniprot/A0A2R9AB12 ^@ Function|||Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.|||Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. http://togogenome.org/gene/9597:CHMP4C ^@ http://purl.uniprot.org/uniprot/A0A2R9C9K3 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9597:KCNK13 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9D5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9597:GUCA2B ^@ http://purl.uniprot.org/uniprot/A0A2R9BDN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylin family.|||Secreted http://togogenome.org/gene/9597:SLC18A3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AKG9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:TYW3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CIA4|||http://purl.uniprot.org/uniprot/A0A2R9CKX5 ^@ Function|||Similarity ^@ Belongs to the TYW3 family.|||Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. http://togogenome.org/gene/9597:ACY3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AI91 ^@ Cofactor|||Similarity ^@ Belongs to the AspA/AstE family. Aspartoacylase subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9597:TMEM126A ^@ http://purl.uniprot.org/uniprot/A0A2R9AB75 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:ADAMTS9 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZXK3|||http://purl.uniprot.org/uniprot/A0A2R8ZXK9 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9597:MRPL37 ^@ http://purl.uniprot.org/uniprot/A0A2R9C6B6 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9597:EP300 ^@ http://purl.uniprot.org/uniprot/A0A2R9ATU0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:PFDN5 ^@ http://purl.uniprot.org/uniprot/A0A2R9BEU9 ^@ Similarity ^@ Belongs to the prefoldin subunit alpha family. http://togogenome.org/gene/9597:TAS2R39 ^@ http://purl.uniprot.org/uniprot/Q646C8 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane|||Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.|||Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). http://togogenome.org/gene/9597:CARNMT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BQL8 ^@ Similarity ^@ Belongs to the carnosine N-methyltransferase family. http://togogenome.org/gene/9597:SMPDL3B ^@ http://purl.uniprot.org/uniprot/A0A2R9ASF8|||http://purl.uniprot.org/uniprot/A0A2R9AWT9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acid sphingomyelinase family.|||Binds 2 Zn(2+) per subunit.|||Secreted http://togogenome.org/gene/9597:NDE1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B0A7|||http://purl.uniprot.org/uniprot/A0A2R9B300 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nudE family.|||centrosome|||kinetochore|||spindle http://togogenome.org/gene/9597:ATP6V0C ^@ http://purl.uniprot.org/uniprot/A0A2R9C662 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.|||Vacuole membrane|||clathrin-coated vesicle membrane|||synaptic vesicle membrane http://togogenome.org/gene/9597:ATP2B2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CH85 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:PERP ^@ http://purl.uniprot.org/uniprot/A0A2R9BV32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/9597:SCGB1D1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BL12 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9597:LOC103785741 ^@ http://purl.uniprot.org/uniprot/A0A2R9CHC6 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:CPEB4 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACA4|||http://purl.uniprot.org/uniprot/A0A2R9ACB4|||http://purl.uniprot.org/uniprot/A0A2R9AH90|||http://purl.uniprot.org/uniprot/A0A2R9AH93 ^@ Similarity ^@ Belongs to the RRM CPEB family. http://togogenome.org/gene/9597:CS ^@ http://purl.uniprot.org/uniprot/A0A2R9BCW0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the citrate synthase family.|||Homodimer.|||Mitochondrion matrix http://togogenome.org/gene/9597:SMARCAD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B6H0 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/9597:LOC103782649 ^@ http://purl.uniprot.org/uniprot/A0A2R9C949 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:CCT2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9597:IZUMO2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BH87 ^@ Similarity ^@ Belongs to the Izumo family. http://togogenome.org/gene/9597:GINS4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GINS4/SLD5 family.|||Chromosome|||Nucleus|||Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. http://togogenome.org/gene/9597:CHRM4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNY6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. http://togogenome.org/gene/9597:AMZ2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AVH1 ^@ Function|||Similarity ^@ Belongs to the peptidase M54 family.|||Probable zinc metalloprotease. http://togogenome.org/gene/9597:SSR2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BCX0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-beta family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/9597:APH1B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDL1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the APH-1 family.|||Component of the gamma-secretase complex.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. http://togogenome.org/gene/9597:GINS3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B3X5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS3/PSF3 family.|||Chromosome|||Component of the GINS complex.|||Nucleus|||The GINS complex plays an essential role in the initiation of DNA replication. http://togogenome.org/gene/9597:ZNF875 ^@ http://purl.uniprot.org/uniprot/A0A2R9A6J8 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:F2RL3 ^@ http://purl.uniprot.org/uniprot/A0A2R9ADF6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9597:LOC100991027 ^@ http://purl.uniprot.org/uniprot/A0A2R9APU6 ^@ Function|||Subunit ^@ In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9597:CERS5 ^@ http://purl.uniprot.org/uniprot/A0A2R9B4F4 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9597:ARL11 ^@ http://purl.uniprot.org/uniprot/A0A2R9ART4 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9597:LUC7L ^@ http://purl.uniprot.org/uniprot/A0A2R9C853|||http://purl.uniprot.org/uniprot/A0A2R9C854 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/9597:CCN3 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABL5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9597:SSX2IP ^@ http://purl.uniprot.org/uniprot/A0A2R9AFH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIP family.|||adherens junction|||centriolar satellite http://togogenome.org/gene/9597:KRT77 ^@ http://purl.uniprot.org/uniprot/A0A2R9ANL2 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9597:NDUFB4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZB3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB4 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:CNDP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AT56 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20A family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9597:MIPEP ^@ http://purl.uniprot.org/uniprot/A0A2R9A5P6 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/9597:ZNF202 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7H9 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9597:ZDHHC16 ^@ http://purl.uniprot.org/uniprot/A0A2R9AAW1|||http://purl.uniprot.org/uniprot/A0A2R9AGG3|||http://purl.uniprot.org/uniprot/A0A2R9AGG7 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9597:LOC100971024 ^@ http://purl.uniprot.org/uniprot/A0A2R9ASA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/9597:G6PC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BC93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9597:CHMP1A ^@ http://purl.uniprot.org/uniprot/A0A2R9AMQ0 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9597:DOP1B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMS1 ^@ Similarity ^@ Belongs to the dopey family. http://togogenome.org/gene/9597:SEMA6D ^@ http://purl.uniprot.org/uniprot/A0A2R9AC21|||http://purl.uniprot.org/uniprot/A0A2R9AC34|||http://purl.uniprot.org/uniprot/A0A2R9AH08|||http://purl.uniprot.org/uniprot/A0A2R9AI10 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:CELF3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CELF/BRUNOL family.|||Nucleus http://togogenome.org/gene/9597:SMAGP ^@ http://purl.uniprot.org/uniprot/A0A2R9CAH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMAGP family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/9597:BLM ^@ http://purl.uniprot.org/uniprot/A0A2R9ATE2 ^@ Similarity ^@ Belongs to the helicase family. RecQ subfamily. http://togogenome.org/gene/9597:GDPGP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDP8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GDPGP1 family.|||Cytoplasm|||Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells. http://togogenome.org/gene/9597:FMO4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9597:PTPN13 ^@ http://purl.uniprot.org/uniprot/A0A2R9BND5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||Regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling.|||cytoskeleton http://togogenome.org/gene/9597:SI ^@ http://purl.uniprot.org/uniprot/A0A2R9A1Y1 ^@ Caution|||Similarity ^@ Belongs to the glycosyl hydrolase 31 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:EMP2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMQ7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the PMP-22/EMP/MP20 family.|||Cell membrane|||Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion.|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Membrane raft|||Nucleus|||perinuclear region http://togogenome.org/gene/9597:HMCES ^@ http://purl.uniprot.org/uniprot/A0A2R9AB05 ^@ Function|||Similarity ^@ Belongs to the SOS response-associated peptidase family.|||Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction. http://togogenome.org/gene/9597:NUP188 ^@ http://purl.uniprot.org/uniprot/A0A2R9BL32 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/9597:EFNB2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A2R0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:MFSD11 ^@ http://purl.uniprot.org/uniprot/A0A2R9CD00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/9597:NTRK3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CFI2|||http://purl.uniprot.org/uniprot/A0A2R9CFJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Membrane http://togogenome.org/gene/9597:RPS19BP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AROS family.|||nucleolus http://togogenome.org/gene/9597:OXSR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1K9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. http://togogenome.org/gene/9597:LOC100970104 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZB08 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:SPSB2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B822 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPSB family.|||Cytoplasm http://togogenome.org/gene/9597:LMX1A ^@ http://purl.uniprot.org/uniprot/A0A2R9ASW8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:ARHGEF12 ^@ http://purl.uniprot.org/uniprot/A0A2R9AYK8|||http://purl.uniprot.org/uniprot/A0A2R9AZ06 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Membrane http://togogenome.org/gene/9597:RPL31 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZRE4|||http://purl.uniprot.org/uniprot/A0A2R8ZSL0 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL31 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/9597:HAPLN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AH74 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:LOC100982295 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMB2 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:C11H11orf58 ^@ http://purl.uniprot.org/uniprot/A0A2R9B475 ^@ Similarity ^@ Belongs to the SMAP family. http://togogenome.org/gene/9597:TBL3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C966 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9597:ALDH2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCP2 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9597:TXNL4B ^@ http://purl.uniprot.org/uniprot/A0A2R9ATQ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/9597:ELOF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BVW6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELOF1 family.|||Nucleus|||Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. http://togogenome.org/gene/9597:EIF3M ^@ http://purl.uniprot.org/uniprot/A0A2R9A5V5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Belongs to the eIF-3 subunit M family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm http://togogenome.org/gene/9597:SFMBT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTG2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:PHF5A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAJ0 ^@ Similarity ^@ Belongs to the PHF5 family. http://togogenome.org/gene/9597:TIMM10 ^@ http://purl.uniprot.org/uniprot/A0A2R9C369 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9597:LHX2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZ03 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:NMD3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CKL2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.|||Belongs to the NMD3 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:BDKRB2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXX3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.|||Membrane|||Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9597:TMED2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BB83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9597:PINLYP ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNF-like-inhibitor family.|||Secreted http://togogenome.org/gene/9597:UBAC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A3K3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:KARS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BGP9 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9597:TMEM35A ^@ http://purl.uniprot.org/uniprot/A0A2R9CE54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Membrane http://togogenome.org/gene/9597:TEKT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ALN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/9597:GSTK1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIL0 ^@ Similarity ^@ Belongs to the GST superfamily. Kappa family. http://togogenome.org/gene/9597:GSTP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJA7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GST superfamily. Pi family.|||Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.|||Cytoplasm|||Homodimer.|||Mitochondrion|||Nucleus http://togogenome.org/gene/9597:DYDC1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZH63 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/9597:HTN3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histatin/statherin family.|||Secreted http://togogenome.org/gene/9597:LOC100988316 ^@ http://purl.uniprot.org/uniprot/A0A2R9BY24 ^@ Similarity ^@ Belongs to the LEO1 family. http://togogenome.org/gene/9597:CPVL ^@ http://purl.uniprot.org/uniprot/A0A2R9BS66 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/9597:PTEN ^@ http://purl.uniprot.org/uniprot/A0A024QYR5 ^@ Similarity ^@ Belongs to the PTEN phosphatase protein family. http://togogenome.org/gene/9597:LOC100978529 ^@ http://purl.uniprot.org/uniprot/A0A2R9BP16 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9597:CUL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BAC0 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9597:SEC11C ^@ http://purl.uniprot.org/uniprot/A0A2R9BF01 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Component of the signal peptidase complex.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:TSPYL1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHP2 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9597:IPMK ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTN4 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9597:GSG1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C053 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSG1 family.|||Membrane http://togogenome.org/gene/9597:WLS ^@ http://purl.uniprot.org/uniprot/A0A2R9AVJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the wntless family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:GCH1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C157 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I family. http://togogenome.org/gene/9597:SLC1A6 ^@ http://purl.uniprot.org/uniprot/A0A2R9CH68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9597:MINAR2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4E7 ^@ Similarity ^@ Belongs to the MINAR family. http://togogenome.org/gene/9597:LSM4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CTE0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/9597:NIF3L1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CLA3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family.|||Cytoplasm|||Homodimer. Interacts with COPS2. Interacts with THOC7.|||May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.|||Nucleus http://togogenome.org/gene/9597:ZNF605 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZY11 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:SST ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatostatin family.|||Secreted http://togogenome.org/gene/9597:LOC100988641 ^@ http://purl.uniprot.org/uniprot/A0A2R9B553 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:MCOLN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B5J6 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9597:STAB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BPI7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:SPOPL ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6S0 ^@ Similarity ^@ Belongs to the Tdpoz family. http://togogenome.org/gene/9597:C19H19orf12 ^@ http://purl.uniprot.org/uniprot/A0A2R9A8G0|||http://purl.uniprot.org/uniprot/A0A2R9A9I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the C19orf12 family.|||Mitochondrion membrane http://togogenome.org/gene/9597:DYNLT5 ^@ http://purl.uniprot.org/uniprot/A0A2R9CKD8 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/9597:DEDD ^@ http://purl.uniprot.org/uniprot/A0A2R9A3L7 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9597:GSX1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AN76 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:PRKAR2B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:ARID1A ^@ http://purl.uniprot.org/uniprot/A0A2R9B7U2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:DDX5 ^@ http://purl.uniprot.org/uniprot/A0A2R9CCA6 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily. http://togogenome.org/gene/9597:JPH3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C555|||http://purl.uniprot.org/uniprot/A0A2R9C7Z5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the junctophilin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.|||Membrane http://togogenome.org/gene/9597:ACE2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BKD8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M2 family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Cytoplasm|||Membrane|||Secreted|||cilium http://togogenome.org/gene/9597:MTX3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C611|||http://purl.uniprot.org/uniprot/A0A2R9C6D4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metaxin family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9597:SLC25A11 ^@ http://purl.uniprot.org/uniprot/A0A2R9C729 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9597:DDX41 ^@ http://purl.uniprot.org/uniprot/A0A2R9A779 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX41 subfamily. http://togogenome.org/gene/9597:GALK2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BVL1 ^@ Similarity ^@ Belongs to the GHMP kinase family. GalK subfamily. http://togogenome.org/gene/9597:CTC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CCG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CTC1 family.|||Nucleus|||telomere http://togogenome.org/gene/9597:ZNF84 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDS5 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:PYCR3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZF5 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/9597:TAGLN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AVL5 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/9597:FAM3A ^@ http://purl.uniprot.org/uniprot/A0A2R9A607 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/9597:LOC100985683 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZY13 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCRB/QCR7 family.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:LOC100978251 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9X5|||http://purl.uniprot.org/uniprot/A0A2R9BUC7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COG8 family.|||Belongs to the polypeptide deformylase family.|||Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.|||Golgi apparatus membrane|||Membrane|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. http://togogenome.org/gene/9597:GABRA4 ^@ http://purl.uniprot.org/uniprot/A0A2R9C6M3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9597:RPS18 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z8K8 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Component of the small ribosomal subunit. http://togogenome.org/gene/9597:RAB18 ^@ http://purl.uniprot.org/uniprot/A0A2R9C799 ^@ Subcellular Location Annotation ^@ Apical cell membrane|||Cell membrane|||Lipid droplet http://togogenome.org/gene/9597:GAL3ST4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BPY0 ^@ Similarity ^@ Belongs to the galactose-3-O-sulfotransferase family. http://togogenome.org/gene/9597:CFHR5 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABK5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:PPM1F ^@ http://purl.uniprot.org/uniprot/A0A2R9CLY1 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9597:TPRG1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYR2 ^@ Similarity ^@ Belongs to the TPRG1 family. http://togogenome.org/gene/9597:PCDHB15 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJT3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:ABCG4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/9597:NMUR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZR68 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for the neuromedin-U and neuromedin-S neuropeptides. http://togogenome.org/gene/9597:NDOR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BP41 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.|||In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||In the N-terminal section; belongs to the flavodoxin family.|||Interacts with CIAPIN1; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.|||NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair.|||perinuclear region http://togogenome.org/gene/9597:HAAO ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9N2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 3-HAO family.|||Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/9597:LY6G5C ^@ http://purl.uniprot.org/uniprot/A0A2R9CSZ1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Forms oligomers.|||May have a role in hematopoietic cell differentiation.|||Secreted http://togogenome.org/gene/9597:LOC100977378 ^@ http://purl.uniprot.org/uniprot/A0A2R9BI85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9597:LOC100974786 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAM8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:SLC39A4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BKS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Membrane http://togogenome.org/gene/9597:IL31RA ^@ http://purl.uniprot.org/uniprot/A0A2R9AHA4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:LSM5 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7R7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. http://togogenome.org/gene/9597:SPTBN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A0X1 ^@ Similarity ^@ Belongs to the spectrin family. http://togogenome.org/gene/9597:POU2F1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BCB2|||http://purl.uniprot.org/uniprot/A0A2R9BCB7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-2 subfamily.|||Nucleus|||Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. http://togogenome.org/gene/9597:COL4A6 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6V2 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.|||basement membrane http://togogenome.org/gene/9597:VAT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7T2 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/9597:GJA5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBI8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9597:ALG2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYD4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family.|||Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.|||Membrane http://togogenome.org/gene/9597:CTSH ^@ http://purl.uniprot.org/uniprot/A0A2R9C3Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9597:NT5E ^@ http://purl.uniprot.org/uniprot/A0A2R9B776 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 5'-nucleotidase family.|||Membrane http://togogenome.org/gene/9597:HDAC3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BGK3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.|||Nucleus http://togogenome.org/gene/9597:CDC42BPG ^@ http://purl.uniprot.org/uniprot/A0A2R9AJ27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.|||Cytoplasm http://togogenome.org/gene/9597:NDUFA3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B995 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA3 subunit family.|||Complex I is composed of 45 different subunits.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9597:TLCD5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZP20 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:SLC13A5 ^@ http://purl.uniprot.org/uniprot/A0A2R9CKV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/9597:RRAGA ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGS2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/9597:SPDYE4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CIC7 ^@ Similarity ^@ Belongs to the Speedy/Ringo family. http://togogenome.org/gene/9597:GALNT6 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:ARK2N ^@ http://purl.uniprot.org/uniprot/A0A2R9B092|||http://purl.uniprot.org/uniprot/A0A2R9B0G9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:FXN ^@ http://purl.uniprot.org/uniprot/A0A2R9BWG5 ^@ Similarity ^@ Belongs to the frataxin family. http://togogenome.org/gene/9597:PTK2B ^@ http://purl.uniprot.org/uniprot/A0A2R9BL74 ^@ Subcellular Location Annotation ^@ Cell membrane|||cell cortex|||focal adhesion http://togogenome.org/gene/9597:TIPRL ^@ http://purl.uniprot.org/uniprot/A0A2R9C8P4 ^@ Similarity ^@ Belongs to the TIP41 family. http://togogenome.org/gene/9597:SLC6A12 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z8I0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Basolateral cell membrane|||Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily.|||Cell membrane|||Interacts with LIN7C.|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9597:CASS4 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6A9 ^@ Similarity ^@ Belongs to the CAS family. http://togogenome.org/gene/9597:LOC100978392 ^@ http://purl.uniprot.org/uniprot/A0A2R9A6L2 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9597:MAB21L2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMH1 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9597:ITGA8 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9597:KATNAL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ATJ5 ^@ Activity Regulation|||Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.|||Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.|||Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.|||Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.|||Cytoplasm|||Interacts with KATNB1 and KATNBL1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Midbody|||Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.|||Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.|||The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.|||Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.|||centrosome|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/9597:SGIP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7T5 ^@ Function|||Subcellular Location Annotation ^@ May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis.|||clathrin-coated pit http://togogenome.org/gene/9597:TUBA8 ^@ http://purl.uniprot.org/uniprot/A0A2R9AU66 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9597:CYP27A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CKX8 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9597:CREB5 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACK7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bZIP family.|||Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1.|||Binds to the cAMP response element and activates transcription.|||Nucleus http://togogenome.org/gene/9597:GFRA3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CCY9 ^@ Similarity ^@ Belongs to the GDNFR family. http://togogenome.org/gene/9597:SMAD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B4S1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:CENPX ^@ http://purl.uniprot.org/uniprot/A0A2R9A6P0 ^@ Similarity ^@ Belongs to the CENP-X/MHF2 family. http://togogenome.org/gene/9597:UNC119B ^@ http://purl.uniprot.org/uniprot/A0A2R9CPV0 ^@ Similarity ^@ Belongs to the PDE6D/unc-119 family. http://togogenome.org/gene/9597:WNT11 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIH8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9597:PPA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJJ7 ^@ Similarity ^@ Belongs to the PPase family. http://togogenome.org/gene/9597:BOLA3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BV74 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/9597:MCIDAS ^@ http://purl.uniprot.org/uniprot/A0A2R9B0E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the geminin family.|||Nucleus http://togogenome.org/gene/9597:DTNBP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BPE4|||http://purl.uniprot.org/uniprot/A0A2R9BQ16 ^@ Similarity ^@ Belongs to the dysbindin family. http://togogenome.org/gene/9597:LOC100989095 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAN6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:UCKL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BQC6 ^@ Similarity ^@ Belongs to the uridine kinase family. http://togogenome.org/gene/9597:EIF2B2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AGX7 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/9597:NIT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A3D8 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. http://togogenome.org/gene/9597:MRPL42 ^@ http://purl.uniprot.org/uniprot/A0A2R9BLQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL42 family.|||Mitochondrion http://togogenome.org/gene/9597:CA14 ^@ http://purl.uniprot.org/uniprot/A0A2R9A052 ^@ Similarity ^@ Belongs to the alpha-carbonic anhydrase family. http://togogenome.org/gene/9597:LOC100973858 ^@ http://purl.uniprot.org/uniprot/A0A2R9BU98 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9597:PRIMPOL ^@ http://purl.uniprot.org/uniprot/A0A2R9BM03 ^@ Similarity ^@ Belongs to the eukaryotic-type primase small subunit family. http://togogenome.org/gene/9597:RWDD3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTP1|||http://purl.uniprot.org/uniprot/A0A2R8ZUW1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9597:SPEM2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BV75 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:MARCHF4 ^@ http://purl.uniprot.org/uniprot/A0A2R9B6S4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:KCNJ13 ^@ http://purl.uniprot.org/uniprot/A0A2R9AFS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9597:HIRIP3 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z920 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:RFC4 ^@ http://purl.uniprot.org/uniprot/A0A2R9C3P2 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/9597:TAS2R1 ^@ http://purl.uniprot.org/uniprot/Q646G9 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane|||Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.|||Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). http://togogenome.org/gene/9597:ELF3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B6Y7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9597:HOGA1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPI7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the final step in the metabolic pathway of hydroxyproline.|||Homotetramer. http://togogenome.org/gene/9597:NEU2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJ98 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/9597:LOC100992828 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCH9 ^@ Similarity ^@ Belongs to the MIF family. http://togogenome.org/gene/9597:GBP6 ^@ http://purl.uniprot.org/uniprot/A0A2R9B0K8 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9597:TNFRSF8 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXI5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:CCNE2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A0P4 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9597:METTL15 ^@ http://purl.uniprot.org/uniprot/A0A2R9A2C6 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. RsmH family. http://togogenome.org/gene/9597:RAD9B ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9Z3 ^@ Similarity ^@ Belongs to the rad9 family. http://togogenome.org/gene/9597:PON1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BCI1 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit.|||Glycosylated. http://togogenome.org/gene/9597:KDM4C ^@ http://purl.uniprot.org/uniprot/A0A2R9CC08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JHDM3 histone demethylase family.|||Nucleus http://togogenome.org/gene/9597:INTS3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B031 ^@ Similarity ^@ Belongs to the Integrator subunit 3 family. http://togogenome.org/gene/9597:ZNF397 ^@ http://purl.uniprot.org/uniprot/A0A2R9C8P1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:NANOG ^@ http://purl.uniprot.org/uniprot/A0A2R8ZE61 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:FAM187B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM187 family.|||Membrane http://togogenome.org/gene/9597:MUL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQV9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:LOXL3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPE4 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/9597:IL1A ^@ http://purl.uniprot.org/uniprot/A0A2R9AMR9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-1 family.|||Cytoplasm|||Monomer.|||Nucleus|||Secreted http://togogenome.org/gene/9597:SPAG7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BWI5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:SEPTIN11 ^@ http://purl.uniprot.org/uniprot/A0A2R9CAW2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9597:WNT5B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJI6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9597:FUT11 ^@ http://purl.uniprot.org/uniprot/A0A2R9AWC4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Membrane|||Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. http://togogenome.org/gene/9597:IL26 ^@ http://purl.uniprot.org/uniprot/A0A2R9ADA9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/9597:TFPI2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVX2 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9597:C2BH2orf76 ^@ http://purl.uniprot.org/uniprot/A0A2R9CI96 ^@ Similarity ^@ Belongs to the UPF0538 family. http://togogenome.org/gene/9597:ETV2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BNU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9597:LTF ^@ http://purl.uniprot.org/uniprot/A0A161IL64 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transferrin family.|||Cytoplasmic granule|||Secreted|||Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. http://togogenome.org/gene/9597:MRPL23 ^@ http://purl.uniprot.org/uniprot/A0A2R9AYS2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/9597:CTBS ^@ http://purl.uniprot.org/uniprot/A0A2R9C459 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 18 family.|||Lysosome http://togogenome.org/gene/9597:DERL3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1B8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Membrane http://togogenome.org/gene/9597:B3GNT2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:PPP1R15B ^@ http://purl.uniprot.org/uniprot/A0A2R9BET9 ^@ Similarity ^@ Belongs to the PPP1R15 family. http://togogenome.org/gene/9597:REXO4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZWM2 ^@ Similarity ^@ Belongs to the REXO4 family. http://togogenome.org/gene/9597:SEMA3C ^@ http://purl.uniprot.org/uniprot/A0A2R9CG16 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9597:LOC100984808 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQT5 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:FXYD3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHG9 ^@ Similarity ^@ Belongs to the FXYD family. http://togogenome.org/gene/9597:SLC35D1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZT85 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:TACSTD2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZC40 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPCAM family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:TMEM9 ^@ http://purl.uniprot.org/uniprot/A0A2R9BPC8 ^@ Similarity ^@ Belongs to the TMEM9 family. http://togogenome.org/gene/9597:ERCC3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B901 ^@ Similarity ^@ Belongs to the helicase family. RAD25/XPB subfamily. http://togogenome.org/gene/9597:LOC100969035 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZB40 ^@ Similarity ^@ Belongs to the pro/parathymosin family. http://togogenome.org/gene/9597:TMEM63A ^@ http://purl.uniprot.org/uniprot/A0A2R9B2E1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/9597:ATP6V0E1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BNP6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase e1/e2 subunit family.|||Membrane|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9597:CFAP97 ^@ http://purl.uniprot.org/uniprot/A0A2R9A6I1 ^@ Similarity ^@ Belongs to the CFAP97 family. http://togogenome.org/gene/9597:UVSSA ^@ http://purl.uniprot.org/uniprot/A0A2R9C1F3 ^@ Similarity ^@ Belongs to the UVSSA family. http://togogenome.org/gene/9597:VPS13A ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9J5|||http://purl.uniprot.org/uniprot/A0A2R8ZDI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS13 family.|||Lipid droplet http://togogenome.org/gene/9597:IWS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5I5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:LCK ^@ http://purl.uniprot.org/uniprot/A0A2R9AKH9|||http://purl.uniprot.org/uniprot/A0A2R9AKJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/9597:DSC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BEU8 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.|||Membrane|||desmosome http://togogenome.org/gene/9597:SLC22A18 ^@ http://purl.uniprot.org/uniprot/A0A2R9AMW0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:DIS3L2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ALF7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.|||Belongs to the RNR ribonuclease family. DIS3L2 subfamily.|||Cytoplasm|||P-body|||Specifically recognizes and binds polyuridylated RNAs via 3 RNA-binding regions (named U-zone 1, U-zone 2 and U-zone 3) that form an open funnel on one face of the catalytic domain, allowing RNA to navigate a path to the active site. http://togogenome.org/gene/9597:SSRP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SSRP1 family.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Nucleus http://togogenome.org/gene/9597:CMKLR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AM00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:GPR107 ^@ http://purl.uniprot.org/uniprot/A0A2R9AI35|||http://purl.uniprot.org/uniprot/A0A2R9AMV1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:TMEM41A ^@ http://purl.uniprot.org/uniprot/A0A2R9A2L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM41 family.|||Membrane http://togogenome.org/gene/9597:MPP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B1M1|||http://purl.uniprot.org/uniprot/A0A2R9B1S9 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/9597:MUC13 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYZ7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:DHRS7C ^@ http://purl.uniprot.org/uniprot/A0A2R9A4E4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9597:CXCL10 ^@ http://purl.uniprot.org/uniprot/A0A2R9BLR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9597:CDC26 ^@ http://purl.uniprot.org/uniprot/A0A2R9B2U5 ^@ Function|||Similarity ^@ Belongs to the CDC26 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. http://togogenome.org/gene/9597:FREM2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXU3 ^@ Similarity ^@ Belongs to the FRAS1 family. http://togogenome.org/gene/9597:B3GNT4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:MEGF8 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUW9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:CDX4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BDJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Caudal homeobox family.|||Nucleus http://togogenome.org/gene/9597:LOC100989331 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZP44 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9597:NDUFC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BE82 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFC1 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:SRXN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AHS2 ^@ Similarity ^@ Belongs to the sulfiredoxin family. http://togogenome.org/gene/9597:VTA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A2S5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTA1 family.|||Cytoplasm|||Endosome membrane|||Membrane http://togogenome.org/gene/9597:BAK1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A7S4 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9597:TMEM245 ^@ http://purl.uniprot.org/uniprot/A0A2R9CCB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/9597:PGPEP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABG4|||http://purl.uniprot.org/uniprot/A0A2R9ABG8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C15 family.|||Cytoplasm|||Removes 5-oxoproline from various penultimate amino acid residues except L-proline. http://togogenome.org/gene/9597:TARS1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJH6 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9597:GTPBP3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUU2|||http://purl.uniprot.org/uniprot/A0A2R8ZVY6|||http://purl.uniprot.org/uniprot/A0A2R8ZVZ0 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. http://togogenome.org/gene/9597:DNAJC27 ^@ http://purl.uniprot.org/uniprot/A0A2R9ANF0 ^@ Function|||Subunit ^@ GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.|||Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms). http://togogenome.org/gene/9597:VAPB ^@ http://purl.uniprot.org/uniprot/A0A2R9AZ86|||http://purl.uniprot.org/uniprot/A0A2R9B5E7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:GPR119 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEY9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9597:C5H5orf22 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9A3 ^@ Similarity ^@ Belongs to the UPF0489 family. http://togogenome.org/gene/9597:TPT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CBI8 ^@ Similarity ^@ Belongs to the TCTP family. http://togogenome.org/gene/9597:BZW2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A7N8 ^@ Similarity ^@ Belongs to the BZW family. http://togogenome.org/gene/9597:NFE2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQP3 ^@ Similarity ^@ Belongs to the bZIP family. CNC subfamily. http://togogenome.org/gene/9597:MAPKAP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSF5|||http://purl.uniprot.org/uniprot/A0A2R9BSK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SIN1 family.|||Cytoplasmic vesicle http://togogenome.org/gene/9597:LANCL3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYM5 ^@ Similarity ^@ Belongs to the LanC-like protein family. http://togogenome.org/gene/9597:NDUFS4 ^@ http://purl.uniprot.org/uniprot/A0A2R9ANH0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS4 subunit family.|||Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:PDSS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BBJ7 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9597:LOC100969609 ^@ http://purl.uniprot.org/uniprot/A0A2R9AVQ7 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/9597:CYP4A22 ^@ http://purl.uniprot.org/uniprot/A0A2R9AE72 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9597:ZNF8 ^@ http://purl.uniprot.org/uniprot/A0A2R9A750 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:TXN ^@ http://purl.uniprot.org/uniprot/A0A2R9CE55 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/9597:NOSIP ^@ http://purl.uniprot.org/uniprot/A0A2R9AWT0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOSIP family.|||Cytoplasm|||Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.|||Nucleus http://togogenome.org/gene/9597:CLTA ^@ http://purl.uniprot.org/uniprot/A0A2R9C0H6|||http://purl.uniprot.org/uniprot/A0A2R9C339 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin light chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||coated pit http://togogenome.org/gene/9597:TMC6 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZR91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMC family.|||Membrane http://togogenome.org/gene/9597:L3HYPDH ^@ http://purl.uniprot.org/uniprot/A0A2R9BWA8 ^@ Similarity ^@ Belongs to the proline racemase family. http://togogenome.org/gene/9597:ALX1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B0M3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:MYBL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CF52 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:APOA4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BIY1 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/9597:SMAD7 ^@ http://purl.uniprot.org/uniprot/A0A2R9AGA7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:RPS14 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZV22 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/9597:EXOC6B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJV0 ^@ Function|||Similarity ^@ Belongs to the SEC15 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/9597:VPS26B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZW95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS26 family.|||Endosome http://togogenome.org/gene/9597:CYP27B1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ALD4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9597:UBE2B ^@ http://purl.uniprot.org/uniprot/A0A2R9BYP7 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9597:LHX5 ^@ http://purl.uniprot.org/uniprot/A0A2R9B0Q4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:PTPRM ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLI9|||http://purl.uniprot.org/uniprot/A0A2R8ZRJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.|||Membrane http://togogenome.org/gene/9597:PSMD11 ^@ http://purl.uniprot.org/uniprot/A0A2R9CMB9 ^@ Similarity ^@ Belongs to the proteasome subunit S9 family. http://togogenome.org/gene/9597:LOC100967520 ^@ http://purl.uniprot.org/uniprot/A0A2R9AY06|||http://purl.uniprot.org/uniprot/A0A2R9B3E8 ^@ Function|||Similarity ^@ Belongs to the SSX family.|||May be involved in transcriptional regulation. http://togogenome.org/gene/9597:AP1S3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CBP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||Membrane|||clathrin-coated pit http://togogenome.org/gene/9597:TIMM17A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTT6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9597:ARRDC4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BXP8 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9597:HOXC10 ^@ http://purl.uniprot.org/uniprot/A0A2R9B7Q3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9597:CRB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BCU6|||http://purl.uniprot.org/uniprot/A0A2R9BGM6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:TRIM54 ^@ http://purl.uniprot.org/uniprot/A0A2R9BCG1 ^@ Function|||Subcellular Location Annotation ^@ May bind and stabilize microtubules during myotubes formation.|||Z line http://togogenome.org/gene/9597:GTF2H1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A8M3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB1 family.|||Nucleus http://togogenome.org/gene/9597:GDE1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AFK3 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9597:VAX1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A8I6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:ADAM2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1V7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:PUS7L ^@ http://purl.uniprot.org/uniprot/A0A2R9CDC6 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruD family. http://togogenome.org/gene/9597:NMNAT2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZV83 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/9597:IGF2BP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C8U3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM IMP/VICKZ family.|||Nucleus|||P-body|||Stress granule|||filopodium|||growth cone|||lamellipodium|||perinuclear region http://togogenome.org/gene/9597:FASLG ^@ http://purl.uniprot.org/uniprot/A0A2R9A5R2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tumor necrosis factor family.|||Cell membrane|||Cytoplasmic form induces gene transcription inhibition.|||Cytoplasmic vesicle lumen|||Lysosome lumen|||Nucleus|||Secreted http://togogenome.org/gene/9597:CDC37L1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BNV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC37 family.|||Cytoplasm http://togogenome.org/gene/9597:TSHZ3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BA29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the teashirt C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/9597:COG3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AUL1 ^@ Function|||Similarity ^@ Belongs to the COG3 family.|||Involved in ER-Golgi transport. http://togogenome.org/gene/9597:FAM76B ^@ http://purl.uniprot.org/uniprot/A0A2R9AQT7 ^@ Similarity ^@ Belongs to the FAM76 family. http://togogenome.org/gene/9597:FA2H ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJK9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sterol desaturase family. SCS7 subfamily.|||Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.|||Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:GBF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CF35 ^@ Subcellular Location Annotation ^@ Golgi apparatus http://togogenome.org/gene/9597:TAS2R16 ^@ http://purl.uniprot.org/uniprot/Q646D1 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor T2R family.|||Cell membrane|||Interacts with RTP3 and RTP4.|||Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.|||Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). http://togogenome.org/gene/9597:CHRNA6 ^@ http://purl.uniprot.org/uniprot/A0A2R9BF04|||http://purl.uniprot.org/uniprot/A0A2R9BIW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9597:TASOR2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A7W7 ^@ Similarity ^@ Belongs to the TASOR family. http://togogenome.org/gene/9597:MAP2K6 ^@ http://purl.uniprot.org/uniprot/A0A2R9BGH1|||http://purl.uniprot.org/uniprot/A0A2R9BHG8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:DYDC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BBM7 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/9597:NRN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C746 ^@ Similarity ^@ Belongs to the neuritin family. http://togogenome.org/gene/9597:HPS6 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCG4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6. Interacts with HPS5 and HPS3. Interacts with biogenesis of lysosome-related organelles complex-1 (BLOC1). Interacts with AP-3 complex.|||May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.|||Microsome membrane http://togogenome.org/gene/9597:PIK3C3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AAE5 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9597:PRKX ^@ http://purl.uniprot.org/uniprot/A0A2R9CL70 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:IL1B ^@ http://purl.uniprot.org/uniprot/A0A2R9BYV3 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-1 family.|||IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.|||Lysosome|||Monomer. Interacts with MEFV.|||Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.|||Secreted|||cytosol|||extracellular exosome http://togogenome.org/gene/9597:CHURC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CGZ1|||http://purl.uniprot.org/uniprot/A0A2R9CQT7 ^@ Similarity ^@ Belongs to the Churchill family. http://togogenome.org/gene/9597:PDSS1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSC1 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9597:CDIPT ^@ http://purl.uniprot.org/uniprot/A0A2R9C1W0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/9597:ABCB6 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJX5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Homodimer.|||Late endosome membrane|||Lysosome membrane|||Melanosome membrane|||Membrane|||Mitochondrion outer membrane|||extracellular exosome|||multivesicular body membrane http://togogenome.org/gene/9597:HYAL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BIQ0|||http://purl.uniprot.org/uniprot/A0A2R9BRK8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/9597:EDC3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C828 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EDC3 family.|||P-body http://togogenome.org/gene/9597:LOC129392920 ^@ http://purl.uniprot.org/uniprot/A0A2R9A427 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/9597:ZNF503 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z5P3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Elbow/Noc family.|||Nucleus http://togogenome.org/gene/9597:NLGN3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A3K6|||http://purl.uniprot.org/uniprot/A0A2R9A705|||http://purl.uniprot.org/uniprot/A0A2R9A7T8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:LAMC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B9I9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||basement membrane http://togogenome.org/gene/9597:HSF4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BGS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/9597:CYP3A5 ^@ http://purl.uniprot.org/uniprot/A0A2R9BZX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9597:MAK16 ^@ http://purl.uniprot.org/uniprot/A0A2R9B4H0 ^@ Similarity ^@ Belongs to the MAK16 family. http://togogenome.org/gene/9597:DPEP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AKL5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.|||Homodimer; disulfide-linked.|||Membrane http://togogenome.org/gene/9597:LCLAT1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVQ4 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9597:ASPA ^@ http://purl.uniprot.org/uniprot/A0A2R9C417 ^@ Cofactor|||Similarity ^@ Belongs to the AspA/AstE family. Aspartoacylase subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9597:PLK4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AC53 ^@ Subcellular Location Annotation ^@ Cleavage furrow|||centriole http://togogenome.org/gene/9597:LOC100978202 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABQ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/9597:SUMO1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin family. SUMO subfamily.|||Nucleus http://togogenome.org/gene/9597:ZIC4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BGI1 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/9597:ARHGEF3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BM68|||http://purl.uniprot.org/uniprot/A0A2R9BN46|||http://purl.uniprot.org/uniprot/A0A2R9BQT6 ^@ Function|||Subcellular Location Annotation ^@ Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.|||Cytoplasm http://togogenome.org/gene/9597:SERPINF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BXC9 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9597:MDFI ^@ http://purl.uniprot.org/uniprot/A0A2R9BNA6 ^@ Similarity ^@ Belongs to the MDFI family. http://togogenome.org/gene/9597:N6AMT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B519 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal PrmC-related family. http://togogenome.org/gene/9597:TUB ^@ http://purl.uniprot.org/uniprot/A0A2R9APF1|||http://purl.uniprot.org/uniprot/A0A2R9AW96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TUB family.|||Secreted http://togogenome.org/gene/9597:ZNF670 ^@ http://purl.uniprot.org/uniprot/A0A2R9CAD1 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:PRND ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prion family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:PPAT ^@ http://purl.uniprot.org/uniprot/A0A2R9C821 ^@ Cofactor|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/9597:TRAF5 ^@ http://purl.uniprot.org/uniprot/A0A2R9AKW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/9597:GFUS ^@ http://purl.uniprot.org/uniprot/A0A2R9A8H5 ^@ Function|||Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.|||Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. http://togogenome.org/gene/9597:GGA3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A587|||http://purl.uniprot.org/uniprot/A0A2R9AAJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GGA protein family.|||Early endosome membrane|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9597:TMEM45A ^@ http://purl.uniprot.org/uniprot/A0A2R9ASW0|||http://purl.uniprot.org/uniprot/A0A2R9ASW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/9597:ACTL8 ^@ http://purl.uniprot.org/uniprot/A0A2R9AUX3 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9597:CCL1 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9597:CNDP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C0F8 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20A family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9597:LYPLA2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLB5 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/9597:NKX3-2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUW0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:HADHB ^@ http://purl.uniprot.org/uniprot/A0A2R9CD86 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/9597:CA13 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZC3 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9597:LHFPL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BM39 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:SMIM8 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM8 family.|||Membrane http://togogenome.org/gene/9597:SMARCA5 ^@ http://purl.uniprot.org/uniprot/A0A2R9A065 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.|||Nucleus http://togogenome.org/gene/9597:GPN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BVZ2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/9597:SLC25A40 ^@ http://purl.uniprot.org/uniprot/A0A2R9CIG5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:NMU ^@ http://purl.uniprot.org/uniprot/A0A2R9BKV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NmU family.|||Secreted http://togogenome.org/gene/9597:IFT70B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZI23 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TTC30/dfy-1/fleer family.|||Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.|||cilium http://togogenome.org/gene/9597:EIF1AD ^@ http://purl.uniprot.org/uniprot/A0A2R8Z714 ^@ Function|||Similarity|||Subunit ^@ Belongs to the EIF1AD family.|||Interacts with GAPDH and STAT1.|||Plays a role into cellular response to oxidative stress. Decreases cell proliferation. http://togogenome.org/gene/9597:DSG3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C2V7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||desmosome http://togogenome.org/gene/9597:KRT13 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZB46|||http://purl.uniprot.org/uniprot/A0A2R8ZHV6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9597:CPA3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CLS4 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9597:TM6SF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CIK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TM6SF family.|||Membrane http://togogenome.org/gene/9597:GCNT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5N5|||http://purl.uniprot.org/uniprot/A0A2R9C5P1|||http://purl.uniprot.org/uniprot/A0A2R9C5P6 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:VIPAS39 ^@ http://purl.uniprot.org/uniprot/A0A2R9B1T3|||http://purl.uniprot.org/uniprot/A0A2R9B5K9 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Early endosome|||Endosome|||Late endosome|||Vesicle http://togogenome.org/gene/9597:IARS1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZI5 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9597:LOC100968283 ^@ http://purl.uniprot.org/uniprot/A0A2R9ASE2 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:CDC42SE2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AGB6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CDC42SE/SPEC family.|||Cell membrane|||Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.|||Membrane|||Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.|||cytoskeleton http://togogenome.org/gene/9597:DOCK5 ^@ http://purl.uniprot.org/uniprot/A0A2R9C3Y7 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9597:ABCG2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZM79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/9597:NLRP9 ^@ http://purl.uniprot.org/uniprot/A0A2R9CN71 ^@ Similarity ^@ Belongs to the NLRP family. http://togogenome.org/gene/9597:ID3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZC46 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:LOC100986475 ^@ http://purl.uniprot.org/uniprot/A0A2R9C247 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9597:LOC100985441 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBN8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:RTF2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSA9 ^@ Similarity|||Subunit ^@ Belongs to the rtf2 family.|||Interacts with DDI2; probably also interacts with DDI1. http://togogenome.org/gene/9597:PNPLA7 ^@ http://purl.uniprot.org/uniprot/A0A2R9AT02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NTE family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:RPS13 ^@ http://purl.uniprot.org/uniprot/A0A2R9BWG0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/9597:SERINC5 ^@ http://purl.uniprot.org/uniprot/A0A2R9BWY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9597:SPAM1 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9G5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 56 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:PIM2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4I5 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.|||Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. http://togogenome.org/gene/9597:ATP6V1G2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQA4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9597:HBQ1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BK37 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9597:BDH1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZ51 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9597:LOC100970998 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7P9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin family. SUMO subfamily.|||Nucleus http://togogenome.org/gene/9597:ADAMTS4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CI30 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9597:TSPAN12 ^@ http://purl.uniprot.org/uniprot/A0A2R9AU53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9597:TSSK6 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZN56 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:CHAC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYH5 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.|||Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. http://togogenome.org/gene/9597:APLNR ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9F6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9597:LOC100988550 ^@ http://purl.uniprot.org/uniprot/A0A2R9CAA2|||http://purl.uniprot.org/uniprot/A0A2R9CAH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:LOC100969587 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKU8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:USP5 ^@ http://purl.uniprot.org/uniprot/A0A2R9BK98 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9597:RPL6 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAQ6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL6 family. http://togogenome.org/gene/9597:ZNF18 ^@ http://purl.uniprot.org/uniprot/A0A2R9AE09|||http://purl.uniprot.org/uniprot/A0A2R9AHY7 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9597:IFI6 ^@ http://purl.uniprot.org/uniprot/A0A2R9AKP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFI6/IFI27 family.|||Membrane http://togogenome.org/gene/9597:PGAM2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXF5 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/9597:BTF3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPJ0 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/9597:METTL26 ^@ http://purl.uniprot.org/uniprot/A0A2R9BH99|||http://purl.uniprot.org/uniprot/A0A2R9BHA3 ^@ Similarity ^@ Belongs to the UPF0585 family. http://togogenome.org/gene/9597:CLDN17 ^@ http://purl.uniprot.org/uniprot/A0A2R9AVC4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9597:PRLR ^@ http://purl.uniprot.org/uniprot/A0A2R9CSZ3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||Interacts with SMARCA1. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.|||Membrane|||The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.|||The box 1 motif is required for JAK interaction and/or activation.|||This is a receptor for the anterior pituitary hormone prolactin. http://togogenome.org/gene/9597:POLR3D ^@ http://purl.uniprot.org/uniprot/A0A2R9A6A7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:TEX13A ^@ http://purl.uniprot.org/uniprot/A0A2R9CLL4 ^@ Similarity ^@ Belongs to the TEX13 family. http://togogenome.org/gene/9597:PYM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJC7|||http://purl.uniprot.org/uniprot/A0A2R9CJF1 ^@ Similarity|||Subunit ^@ Belongs to the pym family.|||Interacts (via N-terminus) with magoh and rbm8a; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex. http://togogenome.org/gene/9597:PHOSPHO1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CFT9 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. PHOSPHO family. http://togogenome.org/gene/9597:SLC7A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BE45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:ASPHD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B2F1 ^@ Similarity ^@ Belongs to the aspartyl/asparaginyl beta-hydroxylase family. http://togogenome.org/gene/9597:FADS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BKZ6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:SND1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CFY9 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. http://togogenome.org/gene/9597:SPCS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:THEMIS ^@ http://purl.uniprot.org/uniprot/A0A2R9AW99 ^@ Similarity ^@ Belongs to the themis family. http://togogenome.org/gene/9597:COQ5 ^@ http://purl.uniprot.org/uniprot/A0A2R9A7V4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).|||Mitochondrion inner membrane http://togogenome.org/gene/9597:ZNF214 ^@ http://purl.uniprot.org/uniprot/A0A2R9BNJ0 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:TSPYL6 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHA4 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9597:PITPNM3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZX56 ^@ Similarity ^@ Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily. http://togogenome.org/gene/9597:DKK3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C8R7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/9597:MED20 ^@ http://purl.uniprot.org/uniprot/A0A2R9AU31 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 20 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9597:APOD ^@ http://purl.uniprot.org/uniprot/A0A2R9AZL2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family.|||Homodimer.|||Secreted http://togogenome.org/gene/9597:ESYT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B1G7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the extended synaptotagmin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:USP16 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKJ4 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C19 family. USP16 subfamily.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Homotetramer.|||Nucleus|||Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. Phosphorylation by AURKB enhances the deubiquitinase activity.|||Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.|||The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin. http://togogenome.org/gene/9597:ZNF212 ^@ http://purl.uniprot.org/uniprot/A0A2R9CAE0 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:TNS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5B6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTEN phosphatase protein family.|||focal adhesion http://togogenome.org/gene/9597:LOC100973465 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUA8 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9597:AP4S1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C6K9|||http://purl.uniprot.org/uniprot/A0A2R9C6L8 ^@ Similarity ^@ Belongs to the adaptor complexes small subunit family. http://togogenome.org/gene/9597:NAPEPLD ^@ http://purl.uniprot.org/uniprot/A0A2R9BCK2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAPE-PLD family.|||Binds 2 zinc divalent cations per subunit.|||Homodimer. Bile acids promote the assembly of inactive monomers into an active dimer and enable catalysis.|||Nucleus envelope http://togogenome.org/gene/9597:ACTR1B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZL16 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9597:APOL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BS79 ^@ Similarity ^@ Belongs to the apolipoprotein L family. http://togogenome.org/gene/9597:MGA ^@ http://purl.uniprot.org/uniprot/A0A2R9B6R6|||http://purl.uniprot.org/uniprot/A0A2R9B6S2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9597:MFSD10 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7J9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:OSGEP ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJ76 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:GLA ^@ http://purl.uniprot.org/uniprot/A0A2R9A2F5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 27 family.|||Homodimer.|||Lysosome http://togogenome.org/gene/9597:GFM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AW37|||http://purl.uniprot.org/uniprot/A0A2R9B001 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.|||Mitochondrion http://togogenome.org/gene/9597:CRAT ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEK7 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/9597:MYF6 ^@ http://purl.uniprot.org/uniprot/A0A2R9ALT9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:SOD3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNC2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Cu-Zn superoxide dismutase family.|||Binds 1 copper ion per subunit.|||Binds 1 zinc ion per subunit.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/9597:LTBP4 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9D5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9597:KRT6A ^@ http://purl.uniprot.org/uniprot/A0A2R9B125 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9597:ASB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BHF6 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9597:ELP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A8V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat ELP2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:RARS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CLD1 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9597:LGI3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BDE6 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9597:LOC100971948 ^@ http://purl.uniprot.org/uniprot/A0A2R9ALK8 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/9597:ATP5F1C ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9T1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase gamma chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. http://togogenome.org/gene/9597:SLC5A4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZK16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:SGK2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AH57 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:TNKS ^@ http://purl.uniprot.org/uniprot/A0A2R9A9V7 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9597:STX12 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5C2 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9597:ARSA ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGT3 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9597:CDC37 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC37 family.|||Cytoplasm http://togogenome.org/gene/9597:SYNJ1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZRH4|||http://purl.uniprot.org/uniprot/A0A2R8ZRH7|||http://purl.uniprot.org/uniprot/A0A2R8ZRI4|||http://purl.uniprot.org/uniprot/A0A2R8ZXB5 ^@ Similarity ^@ Belongs to the synaptojanin family.|||In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family. http://togogenome.org/gene/9597:MSX2 ^@ http://purl.uniprot.org/uniprot/A1YG93 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity).|||Belongs to the Msh homeobox family.|||Interacts with MINT, with XRCC6 (Ku70) and XRCC5 (Ku80).|||Nucleus http://togogenome.org/gene/9597:MRPL49 ^@ http://purl.uniprot.org/uniprot/A0A2R9BNA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL49 family.|||Mitochondrion http://togogenome.org/gene/9597:SLC25A22 ^@ http://purl.uniprot.org/uniprot/A0A2R9CEH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9597:CCDC22 ^@ http://purl.uniprot.org/uniprot/A0A2R9BV45 ^@ Similarity ^@ Belongs to the CCDC22 family. http://togogenome.org/gene/9597:RAP2C ^@ http://purl.uniprot.org/uniprot/A0A2R9BPU5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Palmitoylated.|||Recycling endosome membrane|||Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. http://togogenome.org/gene/9597:LOC100988671 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7U5 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9597:SEMA4G ^@ http://purl.uniprot.org/uniprot/A0A2R9C3P0 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:LOC100994763 ^@ http://purl.uniprot.org/uniprot/A0A2R9CA05 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 6c family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:STPG1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDR7|||http://purl.uniprot.org/uniprot/A0A2R8ZE84 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9597:FAM168B ^@ http://purl.uniprot.org/uniprot/A0A2R8Z695 ^@ Similarity ^@ Belongs to the FAM168 family. http://togogenome.org/gene/9597:TM9SF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CC98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/9597:CCSER2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ADT3|||http://purl.uniprot.org/uniprot/A0A2R9AK67 ^@ Similarity ^@ Belongs to the CCSER family. http://togogenome.org/gene/9597:STAM ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKE2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the STAM family.|||Early endosome membrane|||Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. http://togogenome.org/gene/9597:LOC100989472 ^@ http://purl.uniprot.org/uniprot/A0A2R9BRA7 ^@ Similarity ^@ Belongs to the SPAN-X family. http://togogenome.org/gene/9597:GIMAP4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSD2 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9597:NDUFB11 ^@ http://purl.uniprot.org/uniprot/A0A2R9B427 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB11 subunit family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9597:THADA ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFZ5 ^@ Function|||Similarity ^@ Belongs to the THADA family.|||Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 32 of the anticodon loop of substrate tRNAs. http://togogenome.org/gene/9597:NDUFAF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ATC1 ^@ Function|||Similarity ^@ As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.|||Belongs to the CIA30 family. http://togogenome.org/gene/9597:SUB1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIQ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transcriptional coactivator PC4 family.|||General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).|||Homodimer. Interacts with CSTF2.|||Nucleus http://togogenome.org/gene/9597:NNAT ^@ http://purl.uniprot.org/uniprot/A0A2R9C8E9|||http://purl.uniprot.org/uniprot/A0A2R9C8R6 ^@ Similarity ^@ Belongs to the neuronatin family. http://togogenome.org/gene/9597:ELOVL4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CF78 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ELO family. ELOVL4 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.|||Endoplasmic reticulum membrane|||Membrane|||Oligomer.|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9597:SLC10A7 ^@ http://purl.uniprot.org/uniprot/A0A2R9AI89|||http://purl.uniprot.org/uniprot/A0A2R9AI90|||http://purl.uniprot.org/uniprot/A0A2R9AI94 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Cell membrane|||Does not show transport activity towards bile acids or steroid sulfates.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane http://togogenome.org/gene/9597:MTG1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AGP6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.|||Mitochondrion inner membrane|||Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity. http://togogenome.org/gene/9597:RSAD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BXP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RSAD2 family.|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion inner membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9597:SDHAF1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEV3 ^@ Similarity ^@ Belongs to the complex I LYR family. SDHAF1 subfamily. http://togogenome.org/gene/9597:CCT5 ^@ http://purl.uniprot.org/uniprot/A0A2R9A7U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9597:TCTN3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CK10 ^@ Similarity|||Subunit ^@ Belongs to the tectonic family.|||Part of the tectonic-like complex (also named B9 complex). http://togogenome.org/gene/9597:KCNAB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AAC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shaker potassium channel beta subunit family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9597:LOC100988670 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPT0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9597:TCEANC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9F9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:LOC100980782 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZG75 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:TMC3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9L3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMC family.|||Membrane http://togogenome.org/gene/9597:TK1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ADQ5 ^@ Similarity ^@ Belongs to the thymidine kinase family. http://togogenome.org/gene/9597:SENP3 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9E6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C48 family.|||nucleolus http://togogenome.org/gene/9597:GRK1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIW3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9597:LOC100994646 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:HIGD2A ^@ http://purl.uniprot.org/uniprot/A0A2R9BQ37 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/9597:LOC100996092 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7S6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:TUBGCP4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMP3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.|||centrosome http://togogenome.org/gene/9597:HGS ^@ http://purl.uniprot.org/uniprot/A0A2R9CA74 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Early endosome membrane|||Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.|||multivesicular body membrane http://togogenome.org/gene/9597:CHRNB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BBR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9597:ATG13 ^@ http://purl.uniprot.org/uniprot/A0A2R9CLU2|||http://purl.uniprot.org/uniprot/A0A2R9CLU8|||http://purl.uniprot.org/uniprot/A0A2R9CLV1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.|||Belongs to the ATG13 family. Metazoan subfamily.|||Preautophagosomal structure http://togogenome.org/gene/9597:TMEM182 ^@ http://purl.uniprot.org/uniprot/A0A2R9BN66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM182 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:PARVG ^@ http://purl.uniprot.org/uniprot/A0A2R9BC03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the parvin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:OLFM3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B6U0 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/9597:ACO1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ATW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Cytoplasm http://togogenome.org/gene/9597:LIN54 ^@ http://purl.uniprot.org/uniprot/A0A2R9CED1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-54 family.|||Nucleus http://togogenome.org/gene/9597:LCN8 ^@ http://purl.uniprot.org/uniprot/A0A2R9BBZ7 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9597:PELP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RIX1/PELP1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:CORIN ^@ http://purl.uniprot.org/uniprot/A0A2R9ATW5 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:TMEM129 ^@ http://purl.uniprot.org/uniprot/A0A2R9ANL5|||http://purl.uniprot.org/uniprot/A0A2R9AP74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM129 family.|||Membrane http://togogenome.org/gene/9597:AMPD3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AEV2|||http://purl.uniprot.org/uniprot/A0A2R9AEV7 ^@ Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.|||Homotetramer. http://togogenome.org/gene/9597:LSM14A ^@ http://purl.uniprot.org/uniprot/A0A2R9CDQ6|||http://purl.uniprot.org/uniprot/A0A2R9CDR2 ^@ Similarity ^@ Belongs to the LSM14 family. http://togogenome.org/gene/9597:IPO7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTN9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:PAIP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BVP9 ^@ Similarity ^@ Belongs to the PAIP2 family. http://togogenome.org/gene/9597:TRIM56 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9M8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm http://togogenome.org/gene/9597:OTX2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CE23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9597:IL2RB ^@ http://purl.uniprot.org/uniprot/A0A2R9B5X3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 4 subfamily.|||Cell membrane|||Membrane|||Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation. http://togogenome.org/gene/9597:TSPAN16 ^@ http://purl.uniprot.org/uniprot/A0A2R9AUJ0|||http://purl.uniprot.org/uniprot/A0A2R9B0E9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:ISY1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CAA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ISY1 family.|||Nucleus http://togogenome.org/gene/9597:NDRG2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BQT1|||http://purl.uniprot.org/uniprot/A0A2R9BUA2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDRG family.|||Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.|||Cytoplasm http://togogenome.org/gene/9597:CASP8 ^@ http://purl.uniprot.org/uniprot/A0A2R9AE19 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9597:FAM53C ^@ http://purl.uniprot.org/uniprot/A0A2R9CCJ3 ^@ Similarity ^@ Belongs to the FAM53 family. http://togogenome.org/gene/9597:MMP10 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHX4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9597:CLCF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BCG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-6 superfamily.|||Secreted http://togogenome.org/gene/9597:BRK1 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z8Q5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BRK1 family.|||cytoskeleton http://togogenome.org/gene/9597:FOXB1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKY7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:RAD1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad1 family.|||Nucleus http://togogenome.org/gene/9597:ARF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABQ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/9597:ELL2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Nucleus http://togogenome.org/gene/9597:LOC100972169 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPV7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:ALG8 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG6/ALG8 glucosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:MARK1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B216|||http://purl.uniprot.org/uniprot/A0A2R9B5W9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||dendrite http://togogenome.org/gene/9597:RAB19 ^@ http://purl.uniprot.org/uniprot/A0A2R9APQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane http://togogenome.org/gene/9597:PER3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZN1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9597:GGA1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZK51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GGA protein family.|||Early endosome membrane|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9597:FGF10 ^@ http://purl.uniprot.org/uniprot/A0A2R9BWJ8 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9597:INPP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BIM1 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/9597:CLIC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5B1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/9597:IL2RG ^@ http://purl.uniprot.org/uniprot/A0A2R9BYW9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:LOC100978244 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEJ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:HDX ^@ http://purl.uniprot.org/uniprot/A0A2R9AJW6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:FLOT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AGW3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily.|||Cell membrane|||Endosome|||Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.|||May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.|||Membrane|||Membrane raft|||caveola http://togogenome.org/gene/9597:LASP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9S7|||http://purl.uniprot.org/uniprot/A0A2R8ZG60 ^@ Function|||Subcellular Location Annotation ^@ Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.|||cell cortex|||cytoskeleton http://togogenome.org/gene/9597:EXOSC5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZT64 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:GLUL ^@ http://purl.uniprot.org/uniprot/A0A2R9CBD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamine synthetase family.|||Cell membrane|||Membrane|||Microsome|||Mitochondrion http://togogenome.org/gene/9597:CDCA7L ^@ http://purl.uniprot.org/uniprot/A0A2R9BGC1|||http://purl.uniprot.org/uniprot/A0A2R9BK13 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9597:RBL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BEV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the retinoblastoma protein (RB) family.|||Nucleus http://togogenome.org/gene/9597:VARS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AWC1 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9597:ATP5MG ^@ http://purl.uniprot.org/uniprot/A0A2R8Z8D6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase g subunit family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion http://togogenome.org/gene/9597:LOC100979500 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9M4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:CLDN7 ^@ http://purl.uniprot.org/uniprot/A0A2R9B348 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9597:CRYZ ^@ http://purl.uniprot.org/uniprot/A0A2R9CDZ6 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/9597:TNFSF13B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNW2|||http://purl.uniprot.org/uniprot/A0A2R8ZQJ1 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9597:ZRANB2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BEH2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZRANB2 family.|||Nucleus|||Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection. http://togogenome.org/gene/9597:CYP4F22 ^@ http://purl.uniprot.org/uniprot/A0A2R9C8I6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9597:OPA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BC55|||http://purl.uniprot.org/uniprot/A0A2R9BDG8|||http://purl.uniprot.org/uniprot/A0A2R9BFZ6 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion inner membrane|||Mitochondrion membrane http://togogenome.org/gene/9597:LNPK ^@ http://purl.uniprot.org/uniprot/A0A2R9ABG0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the lunapark family.|||Endoplasmic reticulum membrane|||Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.|||Plays a role in determining ER morphology.|||The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation. http://togogenome.org/gene/9597:HOXA9 ^@ http://purl.uniprot.org/uniprot/A0A2R9A8R7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/9597:RNF43 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZ38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZNRF3 family.|||Cell membrane http://togogenome.org/gene/9597:ABCB8 ^@ http://purl.uniprot.org/uniprot/A0A2R9AS88 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:MSH4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BEZ3 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutS family. http://togogenome.org/gene/9597:RNMT ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.|||In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.|||Nucleus http://togogenome.org/gene/9597:YBEY ^@ http://purl.uniprot.org/uniprot/A0A2R9AKQ5 ^@ Similarity ^@ Belongs to the endoribonuclease YbeY family. http://togogenome.org/gene/9597:RBP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZX83 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9597:POGLUT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A598 ^@ Similarity ^@ Belongs to the KDELC family. http://togogenome.org/gene/9597:CNOT10 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSB8|||http://purl.uniprot.org/uniprot/A0A2R8ZY54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT10 family.|||Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:CTSZ ^@ http://purl.uniprot.org/uniprot/A0A2R9CIR6 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/9597:DNAAF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CEY9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PIH1 family. Kintoun subfamily.|||Cytoplasm|||Interacts with CFAP300. Interacts with DNAI2 and HSPA1A. Interacts with DYX1C1. Interacts with PIH1D3.|||Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. http://togogenome.org/gene/9597:LOC100991751 ^@ http://purl.uniprot.org/uniprot/A0A2R9BFK5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS26 family. http://togogenome.org/gene/9597:CLP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C6Y6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Clp1 family. Clp1 subfamily.|||Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54. Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK.|||Nucleus|||Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing. http://togogenome.org/gene/9597:CHRNA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9T0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9597:DPH6 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9F9|||http://purl.uniprot.org/uniprot/A0A2R8ZG56 ^@ Function|||Similarity ^@ Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.|||Belongs to the Diphthine--ammonia ligase family. http://togogenome.org/gene/9597:APEX1 ^@ http://purl.uniprot.org/uniprot/A1YFZ3 ^@ Activity Regulation|||Cofactor|||Domain|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated on Lys-6 and Lys-7. Acetylation is increased by the transcriptional coactivator EP300 acetyltransferase, genotoxic agents like H(2)O(2) and methyl methanesulfonate (MMS). Acetylation increases its binding affinity to the negative calcium response element (nCaRE) DNA promoter. The acetylated form induces a stronger binding of YBX1 to the Y-box sequence in the MDR1 promoter than the unacetylated form. Deacetylated on lysines. Lys-6 and Lys-7 are deacetylated by SIRT1 (By similarity).|||Belongs to the DNA repair enzymes AP/ExoA family.|||Cleaved at Lys-31 by granzyme A to create the mitochondrial form; leading in reduction of binding to DNA, AP endodeoxyribonuclease activity, redox activation of transcription factors and to enhanced cell death. Cleaved by granzyme K; leading to intracellular ROS accumulation and enhanced cell death after oxidative stress (By similarity).|||Cys-69 and Cys-93 are nitrosylated in response to nitric oxide (NO) and lead to the exposure of the nuclear export signal (NES).|||Cytoplasm|||Endoplasmic reticulum|||Mitochondrion|||Monomer. Homodimer; disulfide-linked. Component of the SET complex, composed of at least APEX1, SET, ANP32A, HMGB2, NME1 and TREX1. Associates with the dimer XRCC5/XRCC6 in a DNA-dependent manner. Interacts with SIRT1; the interaction is increased in the context of genotoxic stress. Interacts with HDAC1, HDAC2 and HDAC3; the interactions are not dependent on the APEX1 acetylation status. Interacts with XRCC1; the interaction is induced by SIRT1 and increased with the APEX1 acetylated form. Interacts with NPM1 (via N-terminal domain); the interaction is RNA-dependent and decreases in hydrogen peroxide-damaged cells. Interacts (via N-terminus) with YBX1 (via C-terminus); the interaction is increased in presence of APEX1 acetylated at Lys-6 and Lys-7. Interacts with HNRNPL; the interaction is DNA-dependent. Interacts (via N-terminus) with KPNA1 and KPNA2. Interacts with TXN; the interaction stimulates the FOS/JUN AP-1 complex DNA-binding activity in a redox-dependent manner. Interacts with GZMA, KRT8, MDM2, POLB, PRDX6, PRPF19, RPLP0, TOMM20 and WDR77. Binds to CDK5 (By similarity).|||Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules. Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER. Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3' side of DNA strand breaks. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB. Plays a role in the protection from granzymes-mediated cellular repair leading to cell death. Also involved in the DNA cleavage step of class switch recombination (CSR). On the other hand, APEX1 also exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR. Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs). Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator of transcriptional repression. Stimulates the YBX1-mediated MDR1 promoter activity, when acetylated at Lys-6 and Lys-7, leading to drug resistance. Acts also as an endoribonuclease involved in the control of single-stranded RNA metabolism. Plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA dinucleotides of the MYC coding region determinant (CRD). In association with NMD1, plays a role in the rRNA quality control process during cell cycle progression. Associates, together with YBX1, on the MDR1 promoter. Together with NPM1, associates with rRNA. Binds DNA and RNA (By similarity).|||NPM1 stimulates endodeoxyribonuclease activity on double-stranded DNA with AP sites, but inhibits endoribonuclease activity on single-stranded RNA containing AP sites.|||Nucleus|||Nucleus speckle|||Phosphorylated. Phosphorylation by kinase PKC or casein kinase CK2 results in enhanced redox activity that stimulates binding of the FOS/JUN AP-1 complex to its cognate binding site. AP-endodeoxyribonuclease activity is not affected by CK2-mediated phosphorylation. Phosphorylation of Thr-233 by CDK5 in response to MPP(+)/MPTP (1-methyl-4-phenylpyridinium) reduces AP-endodeoxyribonuclease activity resulting in accumulation of DNA damage and contributing to neuronal death (By similarity).|||Probably binds two magnesium or manganese ions per subunit.|||The N-terminus contains the redox activity while the C-terminus exerts the DNA AP-endodeoxyribonuclease activity; both function are independent in their actions. An unconventional mitochondrial targeting sequence (MTS) is harbored within the C-terminus, that appears to be masked by the N-terminal sequence containing the nuclear localization signal (NLS), that probably blocks the interaction between the MTS and Tom proteins (By similarity).|||The specific activity of the cleaved mitochondrial endodeoxyribonuclease appeared to be about 3-fold higher than of the full-length form. Extract of mitochondria, but not of nuclei or cytosol, cleaves recombinant APEX1 to generate a mitochondrial APEX1-sized product (By similarity).|||Ubiquitinated by MDM2; leading to translocation to the cytoplasm and proteasomal degradation.|||nucleolus http://togogenome.org/gene/9597:PLPPR2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AWN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9597:ZNF671 ^@ http://purl.uniprot.org/uniprot/A0A2R9CHI0 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:TSPAN5 ^@ http://purl.uniprot.org/uniprot/A0A2R9CKV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9597:SMUG1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AUP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.|||Nucleus http://togogenome.org/gene/9597:WNT16 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZ85 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9597:MAOA ^@ http://purl.uniprot.org/uniprot/A0A2R9ARD5 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/9597:RNFT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BE12 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:RPL7A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHQ8 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Component of the ribosome. http://togogenome.org/gene/9597:MYADML2 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z737 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAL family.|||Membrane http://togogenome.org/gene/9597:SBDS ^@ http://purl.uniprot.org/uniprot/A0A2R9CL09 ^@ Function|||Similarity ^@ Belongs to the SDO1/SBDS family.|||Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. http://togogenome.org/gene/9597:GET3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CEY8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.|||Belongs to the arsA ATPase family.|||Cytoplasm|||Endoplasmic reticulum|||Homodimer. Component of a transmembrane domain recognition complex (TRC). Interacts with SERP1 and SEC61B. Interacts with WRB.|||nucleolus http://togogenome.org/gene/9597:MAP3K8 ^@ http://purl.uniprot.org/uniprot/A0A2R9BD20 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/9597:TEKT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ATM3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/9597:TRIP12 ^@ http://purl.uniprot.org/uniprot/A0A2R9CE67|||http://purl.uniprot.org/uniprot/A0A2R9CE74|||http://purl.uniprot.org/uniprot/A0A2R9CPA6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPL family. K-HECT subfamily.|||E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins.|||nucleoplasm http://togogenome.org/gene/9597:SLC17A7 ^@ http://purl.uniprot.org/uniprot/A0A2R9CBP1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:SLC39A2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ATW1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:BSCL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CF10 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:ZSCAN30 ^@ http://purl.uniprot.org/uniprot/A0A2R9CB23 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:EDN3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B636 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Secreted http://togogenome.org/gene/9597:SLC25A5 ^@ http://purl.uniprot.org/uniprot/A0A2R9BII9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/9597:TMIGD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AS87 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:LOC100972442 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9C5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Secreted http://togogenome.org/gene/9597:PRICKLE2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BE32 ^@ Similarity ^@ Belongs to the prickle / espinas / testin family. http://togogenome.org/gene/9597:PHKA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CAS6|||http://purl.uniprot.org/uniprot/A0A2R9CAX2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.|||Belongs to the phosphorylase b kinase regulatory chain family.|||Cell membrane|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.|||Membrane|||Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. http://togogenome.org/gene/9597:PFKFB3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUU5|||http://purl.uniprot.org/uniprot/A0A2R8ZVW9|||http://purl.uniprot.org/uniprot/A0A2R8ZY79 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/9597:VAMP7 ^@ http://purl.uniprot.org/uniprot/A0A2R9ATW9|||http://purl.uniprot.org/uniprot/A0A2R9AW65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9597:TMOD4 ^@ http://purl.uniprot.org/uniprot/A0A2R9ANE4 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9597:SLC50A1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEU0|||http://purl.uniprot.org/uniprot/A0A2R8ZFB0|||http://purl.uniprot.org/uniprot/A0A2R8ZFB3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SWEET sugar transporter family.|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates sugar transport across membranes.|||Membrane http://togogenome.org/gene/9597:CBX5 ^@ http://purl.uniprot.org/uniprot/A0A2R9A4K7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:RIMKLA ^@ http://purl.uniprot.org/uniprot/A0A2R9AR13 ^@ Similarity ^@ Belongs to the RimK family. http://togogenome.org/gene/9597:SMG9 ^@ http://purl.uniprot.org/uniprot/A0A2R9AAK9 ^@ Similarity ^@ Belongs to the SMG9 family. http://togogenome.org/gene/9597:CLTC ^@ http://purl.uniprot.org/uniprot/A0A2R9A1V6|||http://purl.uniprot.org/uniprot/A0A2R9A770 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin heavy chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||Membrane|||coated pit http://togogenome.org/gene/9597:SLC35F2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZG94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/9597:DKC1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSQ5 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/9597:NME5 ^@ http://purl.uniprot.org/uniprot/A0A2R9ADE6 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9597:OPA3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C1S7|||http://purl.uniprot.org/uniprot/A0A2R9C4S4 ^@ Function|||Similarity ^@ Belongs to the OPA3 family.|||May play some role in mitochondrial processes. http://togogenome.org/gene/9597:GIMAP7 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHS2 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9597:VANGL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BKR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Vang family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:DRP2 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9Q8 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Perikaryon|||Postsynaptic density|||Required for normal myelination and for normal organization of the cytoplasm and the formation of Cajal bands in myelinating Schwann cells. Required for normal PRX location at appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane. Possibly involved in membrane-cytoskeleton interactions of the central nervous system.|||dendrite http://togogenome.org/gene/9597:LOC100980208 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGR2 ^@ Similarity ^@ Belongs to the FAM47 family. http://togogenome.org/gene/9597:PARP4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZM55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARTD/PARP family.|||Nucleus http://togogenome.org/gene/9597:PDK1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9597:PGLS ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUQ4 ^@ Function|||Similarity ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.|||Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. http://togogenome.org/gene/9597:KATNB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BH03 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat KATNB1 family.|||Cytoplasm|||Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome. This interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein, microtubules, NDEL1 and PAFAH1B1. Interacts with KATNAL1; this interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.|||Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.|||centrosome|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/9597:ATP5F1E ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJS5 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ATPase epsilon family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. http://togogenome.org/gene/9597:ARF3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AC12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/9597:CPO ^@ http://purl.uniprot.org/uniprot/A0A2R9AYB1 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9597:CYLD ^@ http://purl.uniprot.org/uniprot/A0A2R9A2C5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||centrosome|||cilium basal body|||perinuclear region|||spindle http://togogenome.org/gene/9597:JMJD1C ^@ http://purl.uniprot.org/uniprot/A0A2R9CGF6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:SPOCK3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AUX5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:MALL ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNM6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:PRC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AVZ8|||http://purl.uniprot.org/uniprot/A0A2R9AW51 ^@ Similarity ^@ Belongs to the MAP65/ASE1 family. http://togogenome.org/gene/9597:DYNLT3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFW4 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/9597:OGG1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AA36 ^@ Function|||Similarity ^@ Belongs to the type-1 OGG1 family.|||DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. http://togogenome.org/gene/9597:DCPS ^@ http://purl.uniprot.org/uniprot/A0A2R9AJD1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HIT family.|||Cytoplasm|||Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway.|||Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.|||Nucleus http://togogenome.org/gene/9597:STAM2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BIG8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the STAM family.|||Early endosome membrane|||Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. http://togogenome.org/gene/9597:LOC106635239 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZK78 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9597:GRAMD1C ^@ http://purl.uniprot.org/uniprot/A0A2R9CQY7 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:TPRA1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZU28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0359 family.|||Membrane http://togogenome.org/gene/9597:ARF5 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/9597:NSFL1C ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUQ8 ^@ Subcellular Location Annotation|||Subunit ^@ Golgi stack|||Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Binds ubiquitin and mono-ubiquitinated proteins via its N-terminal UBA-like domain when bound to VCP. http://togogenome.org/gene/9597:AIF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BT36 ^@ Subcellular Location Annotation ^@ ruffle membrane http://togogenome.org/gene/9597:ADGRF1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZWS3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:GUCY2F ^@ http://purl.uniprot.org/uniprot/A0A2R9CI03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane|||Photoreceptor outer segment membrane http://togogenome.org/gene/9597:STMN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTL6 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/9597:MED12 ^@ http://purl.uniprot.org/uniprot/A0A2R9APR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 12 family.|||Nucleus http://togogenome.org/gene/9597:TSSC4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TSSC4 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:ARHGDIA ^@ http://purl.uniprot.org/uniprot/A0A2R9BA66 ^@ Similarity ^@ Belongs to the Rho GDI family. http://togogenome.org/gene/9597:DIABLO ^@ http://purl.uniprot.org/uniprot/A0A2R8ZB90 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9597:RPS20 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z8W6 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Component of the 40S small ribosomal subunit. http://togogenome.org/gene/9597:SSR3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B068 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-gamma family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/9597:PRDX5 ^@ http://purl.uniprot.org/uniprot/A0A2R9AGM7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxiredoxin family. Prx5 subfamily.|||Peroxisome matrix|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. http://togogenome.org/gene/9597:LOC100991035 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 11 family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9597:TGM2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A118 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9597:PPFIA3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQ03|||http://purl.uniprot.org/uniprot/A0A2R8ZT21 ^@ Similarity ^@ Belongs to the liprin family. Liprin-alpha subfamily. http://togogenome.org/gene/9597:CBR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ARG9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9597:NAB1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZD15 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAB family.|||Homomultimers may associate with EGR1 bound to DNA.|||Nucleus http://togogenome.org/gene/9597:THRB ^@ http://purl.uniprot.org/uniprot/A0A2R9A4E1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9597:LOC100983684 ^@ http://purl.uniprot.org/uniprot/A0A2R9BWN2 ^@ Similarity ^@ Belongs to the SERF family. http://togogenome.org/gene/9597:MAPKAPK3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A884 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:MMD ^@ http://purl.uniprot.org/uniprot/A0A2R9C4U9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9597:SPACA3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BWV7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9597:ITIH6 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/9597:TREH ^@ http://purl.uniprot.org/uniprot/A0A2R9C6C2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 37 family. http://togogenome.org/gene/9597:SAP18 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACB7 ^@ Similarity ^@ Belongs to the SAP18 family. http://togogenome.org/gene/9597:SDHAF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CGW0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SDHAF2 family.|||Interacts with SDHA within the SDH catalytic dimer.|||Mitochondrion matrix|||Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. http://togogenome.org/gene/9597:DDAH2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJA1 ^@ Function|||Similarity ^@ Belongs to the DDAH family.|||Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. http://togogenome.org/gene/9597:RETNLB ^@ http://purl.uniprot.org/uniprot/A0A2R9AYS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the resistin/FIZZ family.|||Secreted http://togogenome.org/gene/9597:LITAF ^@ http://purl.uniprot.org/uniprot/A0A2R9CI52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/9597:LOC100967363 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEX9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:LOC106635329 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z624 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9597:LOC100994750 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCB5 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:TMEM229B ^@ http://purl.uniprot.org/uniprot/A0A2R9ARX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM229 family.|||Membrane http://togogenome.org/gene/9597:LIN28A ^@ http://purl.uniprot.org/uniprot/A0A2R9BMX1 ^@ Similarity ^@ Belongs to the lin-28 family. http://togogenome.org/gene/9597:ITPRIPL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BRH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITPRIP family.|||Membrane http://togogenome.org/gene/9597:DESI1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B6Y9 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/9597:LIN9 ^@ http://purl.uniprot.org/uniprot/A0A2R9A8K6|||http://purl.uniprot.org/uniprot/A0A2R9A8M9 ^@ Similarity ^@ Belongs to the lin-9 family. http://togogenome.org/gene/9597:C8A ^@ http://purl.uniprot.org/uniprot/A0A2R9AG52 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Secreted http://togogenome.org/gene/9597:PPP2R2C ^@ http://purl.uniprot.org/uniprot/A0A2R9BXB7 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/9597:CASQ2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYJ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calsequestrin family.|||Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.|||Sarcoplasmic reticulum lumen http://togogenome.org/gene/9597:MMP20 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9L7 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9597:SEH1L ^@ http://purl.uniprot.org/uniprot/A0A2R8ZD69 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.|||Lysosome membrane|||kinetochore http://togogenome.org/gene/9597:KRT16 ^@ http://purl.uniprot.org/uniprot/A0A2R9BE51 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9597:PVALB ^@ http://purl.uniprot.org/uniprot/A0A2R9CGN7 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/9597:CA10 ^@ http://purl.uniprot.org/uniprot/A0A2R9A615 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Does not have a catalytic activity. http://togogenome.org/gene/9597:VENTX ^@ http://purl.uniprot.org/uniprot/A0A2R9C0P0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:SLC4A8 ^@ http://purl.uniprot.org/uniprot/A0A2R9AN33 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9597:SNAPC3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZM08 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNAPC3/SRD2 family.|||Nucleus|||Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.|||Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. http://togogenome.org/gene/9597:MAP4K3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AAI2|||http://purl.uniprot.org/uniprot/A0A2R9AAI7 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. http://togogenome.org/gene/9597:XPO1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AC81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm http://togogenome.org/gene/9597:KRT20 ^@ http://purl.uniprot.org/uniprot/A0A2R9AN97 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9597:LOC100970784 ^@ http://purl.uniprot.org/uniprot/A0A2R9BEQ1 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:RAB3GAP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A2X7|||http://purl.uniprot.org/uniprot/A0A2R9A751 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab3-GAP catalytic subunit family.|||Cytoplasm|||Endoplasmic reticulum http://togogenome.org/gene/9597:SLC47A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CIM8|||http://purl.uniprot.org/uniprot/A0A2R9CLD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.|||Membrane http://togogenome.org/gene/9597:ZFP69 ^@ http://purl.uniprot.org/uniprot/A0A2R9A6H0 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:HSD17B2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJN5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9597:TBX4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BRB8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9597:SHFL ^@ http://purl.uniprot.org/uniprot/A0A2R9BLJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SHFL family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:DUOXA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DUOXA family.|||Membrane http://togogenome.org/gene/9597:LOC100973098 ^@ http://purl.uniprot.org/uniprot/A0A2R9CBI8 ^@ Similarity ^@ Belongs to the TCTP family. http://togogenome.org/gene/9597:GATA3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZRJ9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:LOC100975643 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMP6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:TRAPPC3L ^@ http://purl.uniprot.org/uniprot/A0A2R9CJN9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||Homodimer.|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||cis-Golgi network http://togogenome.org/gene/9597:TMEM150B ^@ http://purl.uniprot.org/uniprot/A0A2R9CAD4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:KRT74 ^@ http://purl.uniprot.org/uniprot/A0A2R9AVZ5 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9597:ACBD5 ^@ http://purl.uniprot.org/uniprot/A0A2R9BMG7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.|||Belongs to the ATG37 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9597:CRISP2 ^@ http://purl.uniprot.org/uniprot/A0A075IM97 ^@ Caution|||Similarity ^@ Belongs to the CRISP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:MANEAL ^@ http://purl.uniprot.org/uniprot/A0A2R9AR19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 99 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:SUMF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJ41|||http://purl.uniprot.org/uniprot/A0A2R9ARB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase-modifying factor family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9597:CERT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CD16 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum|||Golgi apparatus http://togogenome.org/gene/9597:NSMCE2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CF00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NSE2 family.|||Nucleus http://togogenome.org/gene/9597:FRRS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C039 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FRRS1 family.|||Membrane http://togogenome.org/gene/9597:GYS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUZ0 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase 3 family.|||Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. http://togogenome.org/gene/9597:PTPRE ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:NSUN3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A3P8 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/9597:YPEL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ASV6 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9597:RPAP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B7W3|||http://purl.uniprot.org/uniprot/A0A2R9BA33 ^@ Similarity ^@ Belongs to the RPAP1 family. http://togogenome.org/gene/9597:OAZ2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B1C3 ^@ Similarity ^@ Belongs to the ODC antizyme family. http://togogenome.org/gene/9597:ITGA7 ^@ http://purl.uniprot.org/uniprot/A0A2R9B992|||http://purl.uniprot.org/uniprot/A0A2R9B996|||http://purl.uniprot.org/uniprot/A0A2R9BAN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9597:FAM47E ^@ http://purl.uniprot.org/uniprot/A0A2R9C295 ^@ Similarity ^@ Belongs to the FAM47 family. http://togogenome.org/gene/9597:MANEA ^@ http://purl.uniprot.org/uniprot/A0A2R9CIF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 99 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:RELL2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJI3 ^@ Similarity ^@ Belongs to the RELT family. http://togogenome.org/gene/9597:NDC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ARW8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDC1 family.|||Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.|||Membrane|||Nucleus membrane|||nuclear pore complex http://togogenome.org/gene/9597:DRC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9Z6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC1 family.|||cilium axoneme|||flagellum axoneme http://togogenome.org/gene/9597:PLAUR ^@ http://purl.uniprot.org/uniprot/A0A2R9CLY4|||http://purl.uniprot.org/uniprot/A0A2R9CNW1|||http://purl.uniprot.org/uniprot/A0A2R9CTD1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:MYO3A ^@ http://purl.uniprot.org/uniprot/A0A2R9CG26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||cytoskeleton http://togogenome.org/gene/9597:LOC100993752 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIC3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9597:FDXR ^@ http://purl.uniprot.org/uniprot/A0A2R9BBF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ferredoxin--NADP reductase type 1 family.|||Mitochondrion http://togogenome.org/gene/9597:SLC26A6 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZWF2|||http://purl.uniprot.org/uniprot/A0A2R8ZXL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/9597:PTGR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGR9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADP-dependent oxidoreductase L4BD family.|||Cytoplasm|||Monomer or homodimer. http://togogenome.org/gene/9597:TOMM20 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom20 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9597:ZGPAT ^@ http://purl.uniprot.org/uniprot/A0A2R8ZW92|||http://purl.uniprot.org/uniprot/A0A2R8ZXD4 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with CHD4/Mi-2; the interaction is direct.|||Nucleus http://togogenome.org/gene/9597:RIPK2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CNU8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.|||Cytoplasm|||Found in a signaling complex consisting of at least ARHGEF2, NOD2 and RIPK2.|||Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses. Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments. http://togogenome.org/gene/9597:RAMP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BNU3 ^@ Similarity ^@ Belongs to the RAMP family. http://togogenome.org/gene/9597:ATIC ^@ http://purl.uniprot.org/uniprot/A0A2R9AHH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PurH family.|||cytosol http://togogenome.org/gene/9597:ADI1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AS51|||http://purl.uniprot.org/uniprot/A0A2R9AYN6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acireductone dioxygenase (ARD) family.|||Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.|||Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Also down-regulates cell migration mediated by MMP14.|||Cell membrane|||Cytoplasm|||Monomer. Interacts with MMP14.|||Nucleus http://togogenome.org/gene/9597:B4GALT6 ^@ http://purl.uniprot.org/uniprot/A0A2R9B980|||http://purl.uniprot.org/uniprot/A0A2R9BGQ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9597:MAML2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AVW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mastermind family.|||Nucleus speckle http://togogenome.org/gene/9597:LOC100971133 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZP77 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:ETS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A0Z0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus|||Transcription factor. http://togogenome.org/gene/9597:TXNL4A ^@ http://purl.uniprot.org/uniprot/A0A2R9B0Y0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/9597:DAO ^@ http://purl.uniprot.org/uniprot/A0A2R9AD44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAMOX/DASOX family.|||Peroxisome http://togogenome.org/gene/9597:LOC100992458 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMQ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:PPP1R1B ^@ http://purl.uniprot.org/uniprot/A0A2R9A0A7 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 1 family. http://togogenome.org/gene/9597:PICALM ^@ http://purl.uniprot.org/uniprot/A0A2R9B9L3|||http://purl.uniprot.org/uniprot/A0A2R9BH69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PICALM/SNAP91 family.|||Membrane http://togogenome.org/gene/9597:LOC100969871 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z664 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:NR4A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B4U3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR4 subfamily.|||In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7.|||Nucleus|||cytosol http://togogenome.org/gene/9597:DCAF10 ^@ http://purl.uniprot.org/uniprot/A0A2R9CCE8 ^@ Function|||Similarity ^@ Belongs to the WD repeat DCAF10 family.|||May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. http://togogenome.org/gene/9597:MOB4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSS0|||http://purl.uniprot.org/uniprot/A0A2R9CLU1|||http://purl.uniprot.org/uniprot/A0A2R9CLY0 ^@ Similarity ^@ Belongs to the GroES chaperonin family.|||Belongs to the MOB1/phocein family. http://togogenome.org/gene/9597:ARV1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CIA7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARV1 family.|||Endoplasmic reticulum membrane|||Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.|||Membrane http://togogenome.org/gene/9597:NOG ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAH7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the noggin family.|||Homodimer.|||Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.|||Secreted http://togogenome.org/gene/9597:SEC23B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQH3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9597:LDHB ^@ http://purl.uniprot.org/uniprot/A0A2R9AUG7 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/9597:C1D ^@ http://purl.uniprot.org/uniprot/A0A2R9BSU3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the C1D family.|||Cytoplasm|||Monomer and homodimer.|||Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.|||nucleolus http://togogenome.org/gene/9597:NTNG2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B8T1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:GIMAP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9Q1 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9597:CCL25 ^@ http://purl.uniprot.org/uniprot/A0A2R9AG69 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9597:COQ4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BE98 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ4 family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:KIF9 ^@ http://purl.uniprot.org/uniprot/A0A2R9C3D6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9597:MBOAT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A5F8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:TGS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BRR3 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family. http://togogenome.org/gene/9597:HAX1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A4K5 ^@ Function|||Similarity ^@ Belongs to the HAX1 family.|||Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. http://togogenome.org/gene/9597:CPLX2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BKE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9597:NPRL2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGV7 ^@ Similarity ^@ Belongs to the NPR2 family. http://togogenome.org/gene/9597:ZSCAN29 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCT9 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9597:PARN ^@ http://purl.uniprot.org/uniprot/A0A2R9APG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Cytoplasm http://togogenome.org/gene/9597:LOC100980041 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQ92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:TANGO6 ^@ http://purl.uniprot.org/uniprot/A0A2R9C531 ^@ Similarity ^@ Belongs to the Tango6 family. http://togogenome.org/gene/9597:MRPL47 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZX91 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/9597:PHOSPHO2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZP24 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. PHOSPHO family. http://togogenome.org/gene/9597:SPATA20 ^@ http://purl.uniprot.org/uniprot/A0A2R9AID4|||http://purl.uniprot.org/uniprot/A0A2R9AIE2|||http://purl.uniprot.org/uniprot/A0A2R9AIE4 ^@ Function|||Subcellular Location Annotation ^@ May play a role in fertility regulation.|||Secreted http://togogenome.org/gene/9597:SLX1A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZB37 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SLX1 family.|||Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.|||Forms a heterodimer with SLX4.|||Nucleus http://togogenome.org/gene/9597:GABRA3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AHX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9597:LOC100979846 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKC5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9597:RAB33A ^@ http://purl.uniprot.org/uniprot/A0A2R9BLL4 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Rab family. http://togogenome.org/gene/9597:CLPX ^@ http://purl.uniprot.org/uniprot/A0A2R9C105 ^@ Similarity ^@ Belongs to the ClpX chaperone family. http://togogenome.org/gene/9597:CNOT9 ^@ http://purl.uniprot.org/uniprot/A0A2R9BF52|||http://purl.uniprot.org/uniprot/A0A2R9BF69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT9 family.|||P-body http://togogenome.org/gene/9597:BRF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ARC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIB family.|||Nucleus http://togogenome.org/gene/9597:CENPN ^@ http://purl.uniprot.org/uniprot/A0A2R9B8F1|||http://purl.uniprot.org/uniprot/A0A2R9B8F7|||http://purl.uniprot.org/uniprot/A0A2R9B9W8 ^@ Similarity ^@ Belongs to the CENP-N/CHL4 family. http://togogenome.org/gene/9597:C5H5orf63 ^@ http://purl.uniprot.org/uniprot/A0A2R9CNA0 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/9597:ZNF711 ^@ http://purl.uniprot.org/uniprot/A0A2R9BKX2|||http://purl.uniprot.org/uniprot/A0A2R9BPG3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:DPM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CPW5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum|||Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex. http://togogenome.org/gene/9597:RELT ^@ http://purl.uniprot.org/uniprot/A0A2R9AKJ8 ^@ Similarity ^@ Belongs to the RELT family. http://togogenome.org/gene/9597:FAM161A ^@ http://purl.uniprot.org/uniprot/A0A2R9BGS1|||http://purl.uniprot.org/uniprot/A0A2R9BGS6 ^@ Similarity ^@ Belongs to the FAM161 family. http://togogenome.org/gene/9597:ISL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B1B8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:FAM135A ^@ http://purl.uniprot.org/uniprot/A0A2R9AYL5|||http://purl.uniprot.org/uniprot/A0A2R9B1Y3|||http://purl.uniprot.org/uniprot/A0A2R9B1Z4 ^@ Similarity ^@ Belongs to the FAM135 family. http://togogenome.org/gene/9597:ADH1C ^@ http://purl.uniprot.org/uniprot/A0A2R9BG61 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/9597:ARL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7Z2|||http://purl.uniprot.org/uniprot/A0A2R9CI81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||centrosome http://togogenome.org/gene/9597:HGD ^@ http://purl.uniprot.org/uniprot/A0A2R9AGX4 ^@ Similarity ^@ Belongs to the homogentisate dioxygenase family. http://togogenome.org/gene/9597:CSGALNACT1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZH43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9597:LRP6 ^@ http://purl.uniprot.org/uniprot/A0A2R9B648 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LDLR family.|||Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes.|||Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:ADAMTS1 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z755 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9597:NCOA3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRC/p160 nuclear receptor coactivator family.|||Nucleus http://togogenome.org/gene/9597:FPR3 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z8J0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:KCNK2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9597:PPARGC1A ^@ http://purl.uniprot.org/uniprot/A0A2R9B1U3 ^@ Subcellular Location Annotation ^@ PML body http://togogenome.org/gene/9597:ZNF180 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1Z5 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:HOXB2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZG6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:NFS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYF7 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. http://togogenome.org/gene/9597:MMACHC ^@ http://purl.uniprot.org/uniprot/A0A2R9CDN8 ^@ Similarity ^@ Belongs to the MMACHC family. http://togogenome.org/gene/9597:ZNF461 ^@ http://purl.uniprot.org/uniprot/A0A2R9CCK5|||http://purl.uniprot.org/uniprot/A0A2R9CF77 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:GUCA2A ^@ http://purl.uniprot.org/uniprot/A0A2R9AA40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylin family.|||Secreted http://togogenome.org/gene/9597:ACTR1A ^@ http://purl.uniprot.org/uniprot/A0A2R9AD10 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9597:SLC6A17 ^@ http://purl.uniprot.org/uniprot/A0A2R9CBH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9597:KAT8 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFG4|||http://purl.uniprot.org/uniprot/A0A2R8ZLX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/9597:ERCC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJ12|||http://purl.uniprot.org/uniprot/A0A2R9CJ25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERCC1/RAD10/SWI10 family.|||Nucleus http://togogenome.org/gene/9597:TMEM116 ^@ http://purl.uniprot.org/uniprot/A0A2R9B7C8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:RAD50 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACX5 ^@ Similarity ^@ Belongs to the SMC family. RAD50 subfamily. http://togogenome.org/gene/9597:AFF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYY5 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/9597:PEX5L ^@ http://purl.uniprot.org/uniprot/A0A2R9BA15|||http://purl.uniprot.org/uniprot/A0A2R9BB44 ^@ Similarity ^@ Belongs to the peroxisomal targeting signal receptor family. http://togogenome.org/gene/9597:TMPO ^@ http://purl.uniprot.org/uniprot/A0A2R9AK93 ^@ Similarity ^@ Belongs to the LEM family. http://togogenome.org/gene/9597:PIGH ^@ http://purl.uniprot.org/uniprot/A0A2R9C3M8 ^@ Similarity ^@ Belongs to the PIGH family. http://togogenome.org/gene/9597:PDE8B ^@ http://purl.uniprot.org/uniprot/A0A2R9BFR9 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9597:CNRIP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B9K6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CNRIP family.|||Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.|||Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. http://togogenome.org/gene/9597:SLC25A25 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZP57|||http://purl.uniprot.org/uniprot/A0A2R8ZP71|||http://purl.uniprot.org/uniprot/A0A2R8ZQE2|||http://purl.uniprot.org/uniprot/A0A2R8ZS84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9597:CDPF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CEQ5 ^@ Similarity ^@ Belongs to the CDPF1 family. http://togogenome.org/gene/9597:MTMR6 ^@ http://purl.uniprot.org/uniprot/A0A2R9B6J7 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9597:AGTPBP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CLG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||cytosol http://togogenome.org/gene/9597:SYCE1L ^@ http://purl.uniprot.org/uniprot/A0A2R9C0V3 ^@ Similarity ^@ Belongs to the SYCE family. http://togogenome.org/gene/9597:HSPA5 ^@ http://purl.uniprot.org/uniprot/A0A2R9CFE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 70 family.|||Cell surface|||Endoplasmic reticulum lumen|||Melanosome http://togogenome.org/gene/9597:DEFB110 ^@ http://purl.uniprot.org/uniprot/A0A2R9CCY0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9597:ACOT8 ^@ http://purl.uniprot.org/uniprot/A0A2R9B004 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/9597:ZNF445 ^@ http://purl.uniprot.org/uniprot/A0A2R9BHM2 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9597:HNRNPR ^@ http://purl.uniprot.org/uniprot/A0A2R9CCI5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:DUOX1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDG9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.|||In the N-terminal section; belongs to the peroxidase family.|||Membrane http://togogenome.org/gene/9597:PDE4B ^@ http://purl.uniprot.org/uniprot/A0A2R9ASE9|||http://purl.uniprot.org/uniprot/A0A2R9AWP0 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9597:NES ^@ http://purl.uniprot.org/uniprot/A0A2R9B9M3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9597:MAPRE2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||cytoskeleton http://togogenome.org/gene/9597:ADIPOR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7R4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9597:TNFSF10 ^@ http://purl.uniprot.org/uniprot/A0A2R9C2U3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Homotrimer.|||Membrane|||Secreted http://togogenome.org/gene/9597:SCRN2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYA1 ^@ Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily. http://togogenome.org/gene/9597:MOG ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJZ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Homodimer.|||Membrane|||Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion. http://togogenome.org/gene/9597:ITM2A ^@ http://purl.uniprot.org/uniprot/A0A2R9AP45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITM2 family.|||Membrane http://togogenome.org/gene/9597:LOC100976808 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDD4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCO1/2 family.|||Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2.|||Homodimer.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:INTS8 ^@ http://purl.uniprot.org/uniprot/A0A2R9ARS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 8 family.|||Nucleus http://togogenome.org/gene/9597:ATP6V0A2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BD05 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/9597:RABAC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BKB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/9597:APOLD1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFP6|||http://purl.uniprot.org/uniprot/A0A2R8ZM40 ^@ Similarity ^@ Belongs to the apolipoprotein L family. http://togogenome.org/gene/9597:CNOT3 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7Q9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT2/3/5 family.|||Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity.|||Nucleus|||P-body http://togogenome.org/gene/9597:SMIM14 ^@ http://purl.uniprot.org/uniprot/A0A2R9CID6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9597:GRID2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A3M3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9597:EIF2B4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZRJ0 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/9597:REXO2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BWC5 ^@ Similarity ^@ Belongs to the oligoribonuclease family. http://togogenome.org/gene/9597:ATL3 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z5Z9 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9597:MMP14 ^@ http://purl.uniprot.org/uniprot/A0A2R9BFH7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||Cytoplasm|||Melanosome http://togogenome.org/gene/9597:MYADM ^@ http://purl.uniprot.org/uniprot/A0A2R8Z748 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAL family.|||Membrane http://togogenome.org/gene/9597:EPC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BXZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enhancer of polycomb family.|||Nucleus http://togogenome.org/gene/9597:NRXN3 ^@ http://purl.uniprot.org/uniprot/A0A2R9ALZ5|||http://purl.uniprot.org/uniprot/A0A2R9ARK2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Presynaptic cell membrane http://togogenome.org/gene/9597:SMIM12 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z930|||http://purl.uniprot.org/uniprot/A0A2R8ZA15 ^@ Similarity ^@ Belongs to the SMIM12 family. http://togogenome.org/gene/9597:SLC39A14 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDH0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:CEP44 ^@ http://purl.uniprot.org/uniprot/A0A2R9AH85|||http://purl.uniprot.org/uniprot/A0A2R9AI66 ^@ Subcellular Location Annotation ^@ Midbody|||centriole|||spindle pole http://togogenome.org/gene/9597:POLA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CFV7 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/9597:HS3ST1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDV3 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9597:ALPL ^@ http://purl.uniprot.org/uniprot/A0A2R9ABM8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alkaline phosphatase family.|||Binds 1 Mg(2+) ion.|||Binds 2 Zn(2+) ions.|||Cell membrane|||Homodimer.|||Membrane http://togogenome.org/gene/9597:NPPC ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the natriuretic peptide family.|||Secreted http://togogenome.org/gene/9597:PDE4D ^@ http://purl.uniprot.org/uniprot/A0A2R9CIU9 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9597:RTN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BM18|||http://purl.uniprot.org/uniprot/A0A2R9BM21 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:FMO1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CCZ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:MOK ^@ http://purl.uniprot.org/uniprot/A0A2R9A571|||http://purl.uniprot.org/uniprot/A0A2R9A576|||http://purl.uniprot.org/uniprot/A0A2R9A9X7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:ATP5MC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BIL7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/9597:GRIA3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQ00|||http://purl.uniprot.org/uniprot/A0A2R8ZQ21 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9597:TEK ^@ http://purl.uniprot.org/uniprot/A0A2R9AYN0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:POLD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A8G2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase delta/II small subunit family.|||Nucleus http://togogenome.org/gene/9597:GFRAL ^@ http://purl.uniprot.org/uniprot/A0A2R9BKW6 ^@ Similarity ^@ Belongs to the GDNFR family. http://togogenome.org/gene/9597:DHH ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGI4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the hedgehog family.|||Cell membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane|||Multimer.|||The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.|||The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development. http://togogenome.org/gene/9597:STX11 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCY5 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9597:FAM149B1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYZ0 ^@ Similarity ^@ Belongs to the FAM149 family. http://togogenome.org/gene/9597:HCRT ^@ http://purl.uniprot.org/uniprot/A0A2R9A8A9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the orexin family.|||Endoplasmic reticulum|||Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested.|||Rough endoplasmic reticulum|||Synapse|||Vesicle http://togogenome.org/gene/9597:SMIM7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BHA4 ^@ Similarity ^@ Belongs to the SMIM7 family. http://togogenome.org/gene/9597:SLC35E2B ^@ http://purl.uniprot.org/uniprot/A0A2R9BWQ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:MB ^@ http://purl.uniprot.org/uniprot/A0A2R9BL13 ^@ Function|||Similarity ^@ Belongs to the globin family.|||Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. http://togogenome.org/gene/9597:C8H8orf33 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSY3 ^@ Similarity ^@ Belongs to the UPF0488 family. http://togogenome.org/gene/9597:MACO1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDE8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the macoilin family.|||Endoplasmic reticulum membrane|||Membrane|||Nucleus membrane|||Plays a role in the regulation of neuronal activity.|||Rough endoplasmic reticulum membrane http://togogenome.org/gene/9597:BORA ^@ http://purl.uniprot.org/uniprot/A0A2R9B5B9 ^@ Similarity ^@ Belongs to the BORA family. http://togogenome.org/gene/9597:CD36 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z8H3 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/9597:GABARAPL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B8R1 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9597:CHST9 ^@ http://purl.uniprot.org/uniprot/A0A2R9AA59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:LDAF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BD43|||http://purl.uniprot.org/uniprot/A0A2R9BD48|||http://purl.uniprot.org/uniprot/A0A2R9BLM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LDAF1 family.|||Endoplasmic reticulum membrane|||Lipid droplet|||Membrane http://togogenome.org/gene/9597:CCNJ ^@ http://purl.uniprot.org/uniprot/A0A2R9BUV5 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9597:GRB10 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJ58|||http://purl.uniprot.org/uniprot/A0A2R8ZPN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRB7/10/14 family.|||Cytoplasm http://togogenome.org/gene/9597:CMTR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B885 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with POLR2A (via C-terminus).|||Nucleus|||S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).|||S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. http://togogenome.org/gene/9597:ZDHHC12 ^@ http://purl.uniprot.org/uniprot/A0A2R9BRK9 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9597:PAQR3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4Y4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9597:MMP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C2G5 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9597:NKAPL ^@ http://purl.uniprot.org/uniprot/A0A2R8ZU93 ^@ Similarity ^@ Belongs to the NKAP family. http://togogenome.org/gene/9597:AQP10 ^@ http://purl.uniprot.org/uniprot/A0A2R9B3S8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9597:CPLX4 ^@ http://purl.uniprot.org/uniprot/A0A2R9A7Z4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9597:PRPF18 ^@ http://purl.uniprot.org/uniprot/A0A2R9CC00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP18 family.|||Nucleus speckle http://togogenome.org/gene/9597:LOC100994559 ^@ http://purl.uniprot.org/uniprot/A0A2R9AES3 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9597:VEPH1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B0V6 ^@ Similarity ^@ Belongs to the MELT/VEPH family. http://togogenome.org/gene/9597:LOC100972219 ^@ http://purl.uniprot.org/uniprot/A0A2R9B2U7 ^@ Similarity ^@ Belongs to the NipSnap family. http://togogenome.org/gene/9597:NAP1L3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPP2 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9597:ATOSA ^@ http://purl.uniprot.org/uniprot/A0A2R9BIL9|||http://purl.uniprot.org/uniprot/A0A2R9BIM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATOS family.|||Nucleus http://togogenome.org/gene/9597:ARHGEF9 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMA8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.|||Cytoplasm|||Interacts with GPHN.|||Postsynaptic density http://togogenome.org/gene/9597:GOT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CP09 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/9597:TMEM106C ^@ http://purl.uniprot.org/uniprot/A0A2R9ABZ6 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/9597:UCP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A0R9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||May undergo ubiquitin-mediated proteasomal degradation.|||Membrane|||Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:CLUAP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZXU7|||http://purl.uniprot.org/uniprot/A0A2R9A1M6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLUAP1 family.|||cilium http://togogenome.org/gene/9597:IL36RN ^@ http://purl.uniprot.org/uniprot/A0A2R9C432 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9597:FABP3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A8D8 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9597:ABCD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ADA4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:RAB3GAP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7L3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab3-GAP regulatory subunit family.|||Cytoplasm http://togogenome.org/gene/9597:SGK1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CBV4|||http://purl.uniprot.org/uniprot/A0A2R9CBV5|||http://purl.uniprot.org/uniprot/A0A2R9CC20 ^@ Similarity ^@ Belongs to the protein kinase superfamily.|||Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/9597:RTCB ^@ http://purl.uniprot.org/uniprot/A0A2R9A6G0 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Catalytic component of the tRNA-splicing ligase complex.|||Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.|||Cytoplasm|||Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP. http://togogenome.org/gene/9597:APIP ^@ http://purl.uniprot.org/uniprot/A0A2R9B3W4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aldolase class II family. Adducin subfamily.|||Belongs to the aldolase class II family. MtnB subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.|||Cytoplasm|||Homotetramer. Interacts with APAF1. May interact with CASP1. http://togogenome.org/gene/9597:ESD ^@ http://purl.uniprot.org/uniprot/A0A2R9ACC7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the esterase D family.|||Cytoplasmic vesicle|||Serine hydrolase involved in the detoxification of formaldehyde. http://togogenome.org/gene/9597:ZNF688 ^@ http://purl.uniprot.org/uniprot/A0A2R9B8U9 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:NEFL ^@ http://purl.uniprot.org/uniprot/A0A2R9BTF6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9597:BTD ^@ http://purl.uniprot.org/uniprot/A0A2R9B734 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. http://togogenome.org/gene/9597:SERINC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C3I2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9597:STAMBP ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEM7 ^@ Similarity ^@ Belongs to the peptidase M67C family. http://togogenome.org/gene/9597:YTHDC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5J6|||http://purl.uniprot.org/uniprot/A0A2R9CG49 ^@ Function|||Similarity ^@ Belongs to the YTHDF family.|||Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. http://togogenome.org/gene/9597:PLLP ^@ http://purl.uniprot.org/uniprot/A0A2R9A4G7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:ZFYVE28 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZE26 ^@ Similarity ^@ Belongs to the lst-2 family. http://togogenome.org/gene/9597:LOC100995886 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9P2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme c group covalently per subunit.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9597:RAD51D ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQR0|||http://purl.uniprot.org/uniprot/A0A2R8ZQR4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.|||Nucleus http://togogenome.org/gene/9597:BAMBI ^@ http://purl.uniprot.org/uniprot/A0A2R8Z892 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BAMBI family.|||Membrane|||Negatively regulates TGF-beta signaling. http://togogenome.org/gene/9597:EGR3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A862|||http://purl.uniprot.org/uniprot/A0A2R9A866 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/9597:FAM24A ^@ http://purl.uniprot.org/uniprot/A0A2R9A5R9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM24 family.|||Secreted http://togogenome.org/gene/9597:SNAP47 ^@ http://purl.uniprot.org/uniprot/A0A2R9A994 ^@ Similarity ^@ Belongs to the SVAP1 family. http://togogenome.org/gene/9597:CCKBR ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFK2|||http://purl.uniprot.org/uniprot/A0A2R8ZLJ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9597:TAF6 ^@ http://purl.uniprot.org/uniprot/A0A2R9BD84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF6 family.|||Nucleus http://togogenome.org/gene/9597:AK2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BRP4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK2 subfamily.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Mitochondrion intermembrane space|||Monomer. http://togogenome.org/gene/9597:RHBDD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BC47 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:TUBGCP5 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1W0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.|||centrosome http://togogenome.org/gene/9597:AKAP5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNQ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:FMNL3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A721|||http://purl.uniprot.org/uniprot/A0A2R9ABS3 ^@ Similarity ^@ Belongs to the formin homology family. http://togogenome.org/gene/9597:RBM3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXF1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:TLR5 ^@ http://purl.uniprot.org/uniprot/B3Y635 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9597:LOC100991754 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z5N0 ^@ Similarity ^@ Belongs to the HPF1 family. http://togogenome.org/gene/9597:TNFRSF10D ^@ http://purl.uniprot.org/uniprot/A0A2R9B2D6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:CCT8 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZV23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||cilium basal body http://togogenome.org/gene/9597:SMAD5 ^@ http://purl.uniprot.org/uniprot/A0A2R9BFQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:TBXAS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A342 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9597:SLITRK6 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGU8 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9597:VPS72 ^@ http://purl.uniprot.org/uniprot/A0A2R9BHJ9 ^@ Function|||Similarity ^@ Belongs to the VPS72/YL1 family.|||Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. http://togogenome.org/gene/9597:GPATCH11 ^@ http://purl.uniprot.org/uniprot/A0A2R9CR65 ^@ Similarity ^@ Belongs to the GPATCH11 family. http://togogenome.org/gene/9597:KRT18 ^@ http://purl.uniprot.org/uniprot/A0A2R9CIV2 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9597:FGF6 ^@ http://purl.uniprot.org/uniprot/A0A2R9C1N8 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9597:SUPT16H ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBD0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M24 family. SPT16 subfamily.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Component of the FACT complex.|||Nucleus http://togogenome.org/gene/9597:CYSLTR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZA68 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:MRPS14 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABE5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS14 family. http://togogenome.org/gene/9597:NOX1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZK08|||http://purl.uniprot.org/uniprot/A0A2R8ZL32|||http://purl.uniprot.org/uniprot/A0A2R8ZMV9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:ENSA ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6T2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endosulfine family.|||Cytoplasm|||Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. http://togogenome.org/gene/9597:CKM ^@ http://purl.uniprot.org/uniprot/A0A2R9BMI4 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/9597:CLCC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B0F3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel MCLC family.|||Membrane http://togogenome.org/gene/9597:HOXD12 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJK8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:CPM ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7S1 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9597:NHERF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACP3 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9597:STOML3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BA49 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/9597:RDH11 ^@ http://purl.uniprot.org/uniprot/A0A2R9BIG4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9597:FKTN ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LicD transferase family.|||Golgi apparatus membrane http://togogenome.org/gene/9597:SCGB1A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BEN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the secretoglobin family.|||Secreted http://togogenome.org/gene/9597:EYA1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJ88 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/9597:CCNJL ^@ http://purl.uniprot.org/uniprot/A0A2R9BYM4 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9597:NCAPD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CAQ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CND1 (condensin subunit 1) family.|||Chromosome|||Nucleus|||Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. http://togogenome.org/gene/9597:LIPH ^@ http://purl.uniprot.org/uniprot/A0A2R9BPF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9597:TBX6 ^@ http://purl.uniprot.org/uniprot/A0A2R9A6D9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9597:SLC25A12 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9597:IFITM2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BNR3 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9597:HSPB3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZI34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Nucleus http://togogenome.org/gene/9597:NME7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BXY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||cilium axoneme http://togogenome.org/gene/9597:TNFRSF1B ^@ http://purl.uniprot.org/uniprot/A0A2R9AZK3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:LOC100977566 ^@ http://purl.uniprot.org/uniprot/A0A2R9CF58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||Endoplasmic reticulum http://togogenome.org/gene/9597:SH3BGR ^@ http://purl.uniprot.org/uniprot/A0A2R9BED8 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/9597:PLTP ^@ http://purl.uniprot.org/uniprot/A0A2R9BXI2|||http://purl.uniprot.org/uniprot/A0A2R9BY69|||http://purl.uniprot.org/uniprot/A0A2R9C0W4 ^@ Similarity ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. http://togogenome.org/gene/9597:NUDT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BKH4 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/9597:PORCN ^@ http://purl.uniprot.org/uniprot/A0A2R9AQ84|||http://purl.uniprot.org/uniprot/A0A2R9AQT1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:NAALAD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9A7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:BCO1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZE23 ^@ Cofactor|||Similarity ^@ Belongs to the carotenoid oxygenase family.|||Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/9597:RCAN3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AD09 ^@ Similarity ^@ Belongs to the RCAN family. http://togogenome.org/gene/9597:FN3KRP ^@ http://purl.uniprot.org/uniprot/A0A2R9B1Z0 ^@ Similarity ^@ Belongs to the fructosamine kinase family. http://togogenome.org/gene/9597:PRKAB2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BAT5 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/9597:ARPP19 ^@ http://purl.uniprot.org/uniprot/A0A2R9B6P2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endosulfine family.|||Cytoplasm|||Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. http://togogenome.org/gene/9597:CDK2AP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CG83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDK2AP family.|||Nucleus http://togogenome.org/gene/9597:NHP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A0Y9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/9597:P4HA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1T5|||http://purl.uniprot.org/uniprot/A0A2R9A6B6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9597:LAPTM5 ^@ http://purl.uniprot.org/uniprot/A0A2R9ADL0 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/9597:FN3K ^@ http://purl.uniprot.org/uniprot/A0A2R9CI92 ^@ Similarity ^@ Belongs to the fructosamine kinase family. http://togogenome.org/gene/9597:SNX18 ^@ http://purl.uniprot.org/uniprot/A0A2R9AWI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane http://togogenome.org/gene/9597:BROX ^@ http://purl.uniprot.org/uniprot/A0A2R9BSZ2 ^@ Similarity ^@ Belongs to the BROX family. http://togogenome.org/gene/9597:LDHAL6B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGL5 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/9597:MANF ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARMET family.|||Secreted http://togogenome.org/gene/9597:SUV39H2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AED6|||http://purl.uniprot.org/uniprot/A0A2R9AKX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.|||Nucleus|||centromere http://togogenome.org/gene/9597:ITGA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CTC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9597:PDLIM3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZT1 ^@ Subcellular Location Annotation ^@ Z line http://togogenome.org/gene/9597:ADISSP ^@ http://purl.uniprot.org/uniprot/A0A2R9B4I8 ^@ Similarity ^@ Belongs to the ADISSP family. http://togogenome.org/gene/9597:GPR35 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5G3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9597:GBP7 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYF8 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9597:MMAB ^@ http://purl.uniprot.org/uniprot/A0A2R9ANE0 ^@ Similarity ^@ Belongs to the Cob(I)alamin adenosyltransferase family. http://togogenome.org/gene/9597:RAF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B7H5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. http://togogenome.org/gene/9597:EOGT ^@ http://purl.uniprot.org/uniprot/A0A2R9BZ03 ^@ Similarity ^@ Belongs to the glycosyltransferase 61 family. http://togogenome.org/gene/9597:CHM ^@ http://purl.uniprot.org/uniprot/A0A2R9B236 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. http://togogenome.org/gene/9597:ZDHHC22 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHJ0 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9597:GIMAP6 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXZ2 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9597:FNIP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNIP family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9597:FNIP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYV7|||http://purl.uniprot.org/uniprot/A0A2R9C233 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNIP family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9597:TNFRSF25 ^@ http://purl.uniprot.org/uniprot/A0A2R9BER1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:TNFRSF14 ^@ http://purl.uniprot.org/uniprot/A0A2R9C593 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:MRPS25 ^@ http://purl.uniprot.org/uniprot/A0A2R9BU01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS25 family.|||Mitochondrion http://togogenome.org/gene/9597:LYVE1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYT0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:RHCG ^@ http://purl.uniprot.org/uniprot/A0A2R9C1Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/9597:TRAK2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B948 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the milton family.|||Early endosome|||Mitochondrion http://togogenome.org/gene/9597:LOC100977441 ^@ http://purl.uniprot.org/uniprot/A0A2R9AN85 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/9597:KCNG1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AKC5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:UIMC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B8V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAP80 family.|||Nucleus http://togogenome.org/gene/9597:MRPL51 ^@ http://purl.uniprot.org/uniprot/A0A2R9BXA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL51 family.|||Mitochondrion http://togogenome.org/gene/9597:BCHE ^@ http://purl.uniprot.org/uniprot/A0A2R9BEU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Secreted http://togogenome.org/gene/9597:LIN28B ^@ http://purl.uniprot.org/uniprot/A0A2R9BPJ2|||http://purl.uniprot.org/uniprot/A0A2R9BPL2 ^@ Similarity ^@ Belongs to the lin-28 family. http://togogenome.org/gene/9597:PREB ^@ http://purl.uniprot.org/uniprot/A0A2R9A6R4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat SEC12 family.|||Endoplasmic reticulum membrane|||Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.|||Interacts with SAR1B (GDP-bound form). Interacts with MIA2; recruits PREB to endoplasmic reticulum exit sites.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription. http://togogenome.org/gene/9597:DAG1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BAV6 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.|||Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.|||cytoskeleton|||extracellular space|||nucleoplasm|||sarcolemma http://togogenome.org/gene/9597:DGLUCY ^@ http://purl.uniprot.org/uniprot/A0A2R9AQG9|||http://purl.uniprot.org/uniprot/A0A2R9AQH5 ^@ Similarity ^@ Belongs to the D-glutamate cyclase family. http://togogenome.org/gene/9597:STXBP5 ^@ http://purl.uniprot.org/uniprot/A0A2R9AW10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat L(2)GL family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9597:WSCD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDK2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WSCD family.|||Golgi apparatus membrane|||Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans. http://togogenome.org/gene/9597:DDX3X ^@ http://purl.uniprot.org/uniprot/A0A2R9C920 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9597:LOC100974054 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6W3 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:TMEM151A ^@ http://purl.uniprot.org/uniprot/A0A2R9AY98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM151 family.|||Membrane http://togogenome.org/gene/9597:HSD17B6 ^@ http://purl.uniprot.org/uniprot/A0A2R9A4K9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9597:MESD ^@ http://purl.uniprot.org/uniprot/A0A2R8ZE28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MESD family.|||Endoplasmic reticulum http://togogenome.org/gene/9597:CYP2B6 ^@ http://purl.uniprot.org/uniprot/A0A2R9AIM3 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9597:GRIN2A ^@ http://purl.uniprot.org/uniprot/A0A2R9AYV3|||http://purl.uniprot.org/uniprot/A0A2R9AYX0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/9597:DTYMK ^@ http://purl.uniprot.org/uniprot/A0A2R9C564 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/9597:PON2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A6X3 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit.|||Glycosylated. http://togogenome.org/gene/9597:ITGAM ^@ http://purl.uniprot.org/uniprot/A0A2R9BGM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9597:CACNA1D ^@ http://purl.uniprot.org/uniprot/A0A2R9CK68|||http://purl.uniprot.org/uniprot/A0A2R9CK78|||http://purl.uniprot.org/uniprot/A0A2R9CMS6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily.|||Membrane|||Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. http://togogenome.org/gene/9597:SLC16A13 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJE6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:CENPH ^@ http://purl.uniprot.org/uniprot/A0A2R9BSG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-H/MCM16 family.|||Nucleus|||kinetochore http://togogenome.org/gene/9597:XPO6 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZ27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:GSTZ1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C487 ^@ Similarity ^@ Belongs to the GST superfamily. Zeta family. http://togogenome.org/gene/9597:PUS10 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQ34 ^@ Similarity ^@ Belongs to the pseudouridine synthase Pus10 family. http://togogenome.org/gene/9597:RSPO1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CBB0 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/9597:ZNF514 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJR5 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:SERPINA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CIS5 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9597:S100A4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZE71 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9597:PCDHB8 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEH8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:MPP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C400 ^@ Function|||Subcellular Location Annotation ^@ Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity.|||stereocilium http://togogenome.org/gene/9597:ZNF772 ^@ http://purl.uniprot.org/uniprot/A0A2R9A2F1|||http://purl.uniprot.org/uniprot/A0A2R9A3W7 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:FBLN5 ^@ http://purl.uniprot.org/uniprot/A0A2R9BAT7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:CRYBA1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFR9 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9597:NXT1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJN6 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/9597:PPP1R2C ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQ88 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 2 family. http://togogenome.org/gene/9597:NTNG1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CK20|||http://purl.uniprot.org/uniprot/A0A2R9CMN7|||http://purl.uniprot.org/uniprot/A0A2R9CSI1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:LOC100980965 ^@ http://purl.uniprot.org/uniprot/A0A2R9BFF8 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9597:SMAD3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AV36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:NMNAT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C2A2 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/9597:BRINP3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJ41 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/9597:MEOX2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHB4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:HM13 ^@ http://purl.uniprot.org/uniprot/A0A2R9AMI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A22B family.|||Membrane http://togogenome.org/gene/9597:TFAP2B ^@ http://purl.uniprot.org/uniprot/A0A2R9AMI2 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/9597:ZNF543 ^@ http://purl.uniprot.org/uniprot/A0A2R9B0R2 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:MPPE1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZL51|||http://purl.uniprot.org/uniprot/A0A2R8ZL54 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metallophosphoesterase superfamily. MPPE1 family.|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Interacts with GPI-anchor proteins. Interacts with TMED10.|||Membrane|||Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.|||cis-Golgi network membrane http://togogenome.org/gene/9597:SLC25A39 ^@ http://purl.uniprot.org/uniprot/A0A2R9BZD3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:KCNK1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Cell membrane|||Cytoplasmic vesicle|||Endosome|||Membrane|||Perikaryon|||Recycling endosome|||Synaptic cell membrane|||Vesicle|||dendrite http://togogenome.org/gene/9597:ZFP36 ^@ http://purl.uniprot.org/uniprot/A0A2R9AM16 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.|||Cytoplasm|||Nucleus|||Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. http://togogenome.org/gene/9597:SMC3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AH80 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC3 subfamily.|||Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.|||Nucleus|||centromere http://togogenome.org/gene/9597:PAX7 ^@ http://purl.uniprot.org/uniprot/A0A2R9AC01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/9597:OTULINL ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C65 family. Otulin subfamily.|||Cytoplasm http://togogenome.org/gene/9597:CWC25 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZL90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CWC25 family.|||Nucleus http://togogenome.org/gene/9597:KCNJ9 ^@ http://purl.uniprot.org/uniprot/A0A2R9B157 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9597:TXNRD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AKG2 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/9597:NPVF ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FARP (FMRFamide related peptide) family.|||Secreted http://togogenome.org/gene/9597:KPNA4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEY4 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9597:STK40 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTT0 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.|||Nucleus http://togogenome.org/gene/9597:TRIM21 ^@ http://purl.uniprot.org/uniprot/A0A2R9CHV1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:LXN ^@ http://purl.uniprot.org/uniprot/A0A2R9CAF3 ^@ Similarity ^@ Belongs to the protease inhibitor I47 (latexin) family. http://togogenome.org/gene/9597:FAM118B ^@ http://purl.uniprot.org/uniprot/A0A2R9A5B6 ^@ Similarity ^@ Belongs to the FAM118 family. http://togogenome.org/gene/9597:GDF15 ^@ http://purl.uniprot.org/uniprot/A0A2R9BNA9 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9597:LOC100970363 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX17 family.|||Mitochondrion intermembrane space http://togogenome.org/gene/9597:AURKB ^@ http://purl.uniprot.org/uniprot/A0A2R9A9B4|||http://purl.uniprot.org/uniprot/A0A2R9A9Y3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. http://togogenome.org/gene/9597:LOC100983833 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTV5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:TNFSF15 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVZ2 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9597:CABS1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZB06 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Membrane|||Mitochondrion inner membrane|||flagellum http://togogenome.org/gene/9597:LLPH ^@ http://purl.uniprot.org/uniprot/A0A2R9CLC3 ^@ Similarity ^@ Belongs to the learning-associated protein family. http://togogenome.org/gene/9597:MPC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AMQ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9597:MRPS9 ^@ http://purl.uniprot.org/uniprot/A0A2R9BGM3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/9597:SYT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A4D0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.|||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.|||synaptic vesicle membrane http://togogenome.org/gene/9597:LOC103785886 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKJ3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9597:LOC100981041 ^@ http://purl.uniprot.org/uniprot/A0A2R9APZ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:SSTR2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAV2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).|||Membrane|||Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization. http://togogenome.org/gene/9597:PADI2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BZA0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein arginine deiminase family.|||Catalyzes the deimination of arginine residues of proteins.|||Cytoplasm http://togogenome.org/gene/9597:TNNT3 ^@ http://purl.uniprot.org/uniprot/A0A2R9ARJ3 ^@ Function|||Similarity ^@ Belongs to the troponin T family.|||Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. http://togogenome.org/gene/9597:ARCN1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZXI8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/9597:SEC24D ^@ http://purl.uniprot.org/uniprot/A0A2R9A1R5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9597:LOC100995226 ^@ http://purl.uniprot.org/uniprot/A0A2R9CGS3 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Lysosome membrane http://togogenome.org/gene/9597:CSNK1G1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BBQ7|||http://purl.uniprot.org/uniprot/A0A2R9BBS5|||http://purl.uniprot.org/uniprot/A0A2R9BFG2|||http://purl.uniprot.org/uniprot/A0A2R9BFH2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. http://togogenome.org/gene/9597:CRYBG3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BY08 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9597:PCMTD1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZA41|||http://purl.uniprot.org/uniprot/A0A2R8ZAJ3 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/9597:IAPP ^@ http://purl.uniprot.org/uniprot/A0A2R9ATQ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calcitonin family.|||Secreted|||Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. http://togogenome.org/gene/9597:DHDH ^@ http://purl.uniprot.org/uniprot/A0A2R9BFW6 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. http://togogenome.org/gene/9597:VSIG1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B5R4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:FOXN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CR70 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:LOC103784797 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PET117 family.|||Mitochondrion http://togogenome.org/gene/9597:MCMBP ^@ http://purl.uniprot.org/uniprot/A0A2R9C673 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCMBP family.|||Nucleus http://togogenome.org/gene/9597:ZFHX2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BVA3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:CXCL9 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9597:CASP9 ^@ http://purl.uniprot.org/uniprot/A0A2R9CHF2 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9597:FOXN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BEA1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:TYROBP ^@ http://purl.uniprot.org/uniprot/A0A2R9C1E2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TYROBP family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:UBLCP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AF35 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:PF4V1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZN72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9597:MED27 ^@ http://purl.uniprot.org/uniprot/A0A2R9CFW4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 27 family.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9597:TRMU ^@ http://purl.uniprot.org/uniprot/A0A2R9AVX0|||http://purl.uniprot.org/uniprot/A0A2R9AZY4 ^@ Function|||Similarity ^@ Belongs to the MnmA/TRMU family.|||Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base. http://togogenome.org/gene/9597:FAM168A ^@ http://purl.uniprot.org/uniprot/A0A2R9CEJ3 ^@ Similarity ^@ Belongs to the FAM168 family. http://togogenome.org/gene/9597:SMOC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJ17 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:MPP7 ^@ http://purl.uniprot.org/uniprot/A0A2R9AP32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||adherens junction|||tight junction http://togogenome.org/gene/9597:MRPL52 ^@ http://purl.uniprot.org/uniprot/A0A2R9AYJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL52 family.|||Mitochondrion http://togogenome.org/gene/9597:RELL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AH43 ^@ Similarity ^@ Belongs to the RELT family. http://togogenome.org/gene/9597:POLE ^@ http://purl.uniprot.org/uniprot/A0A2R9AX07 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B family.|||DNA polymerase II participates in chromosomal DNA replication.|||Nucleus http://togogenome.org/gene/9597:PLXNB3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A7S3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the plexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:FEN1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQP1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Mitochondrion|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9597:PMS1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZD19|||http://purl.uniprot.org/uniprot/A0A2R8ZD34 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/9597:LOC100993343 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGT5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:GPR89A ^@ http://purl.uniprot.org/uniprot/A0A2R9A501|||http://purl.uniprot.org/uniprot/A0A2R9A672 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Golgi pH regulator (TC 1.A.38) family.|||Membrane http://togogenome.org/gene/9597:PIGN ^@ http://purl.uniprot.org/uniprot/A0A2R9BVL4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.|||Endoplasmic reticulum membrane|||Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:LANCL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BWF6 ^@ Similarity ^@ Belongs to the LanC-like protein family. http://togogenome.org/gene/9597:TJAP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A7C1|||http://purl.uniprot.org/uniprot/A0A2R9A7D7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:SNRPA ^@ http://purl.uniprot.org/uniprot/A0A2R9AYG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM U1 A/B'' family.|||Nucleus http://togogenome.org/gene/9597:SARAF ^@ http://purl.uniprot.org/uniprot/A0A2R9ANW0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SARAF family.|||Endoplasmic reticulum membrane|||Interacts with STIM1; the interaction is inhibit by th interaction of STIM1 with EFHB.|||Membrane|||Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions. http://togogenome.org/gene/9597:NOXA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BG68 ^@ Similarity ^@ Belongs to the NCF2/NOXA1 family. http://togogenome.org/gene/9597:RAD23A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJH2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAD23 family.|||Cytoplasm|||Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.|||Nucleus http://togogenome.org/gene/9597:NCEH1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZF52 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/9597:SGMS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4A6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/9597:MGAM2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B3A5 ^@ Caution|||Similarity ^@ Belongs to the glycosyl hydrolase 31 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:CSRNP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CD71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AXUD1 family.|||Nucleus http://togogenome.org/gene/9597:CREBL2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZR97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. ATF subfamily.|||Nucleus http://togogenome.org/gene/9597:SLC7A2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:SF3A3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AX82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3A3 family.|||Nucleus http://togogenome.org/gene/9597:FGD3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A912 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9597:TAFA4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BU10 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/9597:LOC100976754 ^@ http://purl.uniprot.org/uniprot/A0A2R9C0I3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lambda interferon family.|||Secreted http://togogenome.org/gene/9597:PRMT5 ^@ http://purl.uniprot.org/uniprot/A0A2R9AKS4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).|||Belongs to the class I-like SAM-binding methyltransferase superfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:MCM6 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZL26 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/9597:FAM131A ^@ http://purl.uniprot.org/uniprot/A0A2R9BJG3 ^@ Similarity ^@ Belongs to the FAM131 family. http://togogenome.org/gene/9597:TPPP3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BVJ5 ^@ Similarity ^@ Belongs to the TPPP family. http://togogenome.org/gene/9597:LOC100983071 ^@ http://purl.uniprot.org/uniprot/A0A2R9C1C8 ^@ Similarity ^@ Belongs to the CBP3 family. http://togogenome.org/gene/9597:ING4 ^@ http://purl.uniprot.org/uniprot/A0A2R9B458 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9597:MYOF ^@ http://purl.uniprot.org/uniprot/A0A2R9C196 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ferlin family.|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/9597:CD40LG ^@ http://purl.uniprot.org/uniprot/A0A2R9CD52 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.|||Belongs to the tumor necrosis factor family.|||Cell surface|||Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.|||Homotrimer. http://togogenome.org/gene/9597:ADCY8 ^@ http://purl.uniprot.org/uniprot/A0A2R9BI25|||http://purl.uniprot.org/uniprot/A0A2R9BKQ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/9597:UROD ^@ http://purl.uniprot.org/uniprot/A0A2R9B7D3|||http://purl.uniprot.org/uniprot/A0A2R9BB53 ^@ Similarity|||Subunit ^@ Belongs to the uroporphyrinogen decarboxylase family.|||Homodimer. http://togogenome.org/gene/9597:DHDDS ^@ http://purl.uniprot.org/uniprot/A0A2R9AFF5|||http://purl.uniprot.org/uniprot/A0A2R9AFF8 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/9597:RELN ^@ http://purl.uniprot.org/uniprot/A0A2R9B232 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the reelin family.|||Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Oligomer of disulfide-linked homodimers. Binds to the ectodomains of VLDLR and LRP8/APOER2.|||extracellular matrix http://togogenome.org/gene/9597:RIN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZU9 ^@ Similarity ^@ Belongs to the RIN (Ras interaction/interference) family. http://togogenome.org/gene/9597:DMAP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BEF6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:NTMT2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYR2 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. NTM1 family. http://togogenome.org/gene/9597:LOC100986809 ^@ http://purl.uniprot.org/uniprot/A0A2R9B346 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9597:LOC100974017 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZT84 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:TPD52 ^@ http://purl.uniprot.org/uniprot/A0A2R9BQP3 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/9597:RNF167 ^@ http://purl.uniprot.org/uniprot/A0A2R9BN69 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:NARF ^@ http://purl.uniprot.org/uniprot/A0A2R9BB87 ^@ Similarity ^@ Belongs to the NARF family. http://togogenome.org/gene/9597:CFAP107 ^@ http://purl.uniprot.org/uniprot/A0A2R9ASN0|||http://purl.uniprot.org/uniprot/A0A2R9AX14 ^@ Function|||Subcellular Location Annotation ^@ Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.|||cilium axoneme http://togogenome.org/gene/9597:SLC2A11 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1R2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Cell membrane http://togogenome.org/gene/9597:BEST2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BDZ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms calcium-sensitive chloride channels. Permeable to bicarbonate.|||Membrane http://togogenome.org/gene/9597:CCNDBP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B143 ^@ Similarity|||Subunit ^@ Belongs to the CCNDBP1 family.|||Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3. http://togogenome.org/gene/9597:UGCG ^@ http://purl.uniprot.org/uniprot/A0A2R9CLW0 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/9597:TRAF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C863 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/9597:ERBB2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C656 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/9597:INTS13 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the asunder family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:USP33 ^@ http://purl.uniprot.org/uniprot/A0A2R9CQ86 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family. USP20/USP33 subfamily.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||centrosome|||perinuclear region http://togogenome.org/gene/9597:REN ^@ http://purl.uniprot.org/uniprot/A0A2R9C0Y1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A1 family.|||Interacts with ATP6AP2.|||Membrane|||Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. http://togogenome.org/gene/9597:LOC100993694 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCN1 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:GMPPA ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVG5 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/9597:ERF ^@ http://purl.uniprot.org/uniprot/A0A2R8ZX10|||http://purl.uniprot.org/uniprot/A0A2R9A2L3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9597:LOC103784642 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQR0 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:BRPF1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHL4|||http://purl.uniprot.org/uniprot/A0A2R8ZNV3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:CORO1C ^@ http://purl.uniprot.org/uniprot/A0A2R9APZ3 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/9597:ASPDH ^@ http://purl.uniprot.org/uniprot/A0A2R9A749 ^@ Similarity ^@ Belongs to the L-aspartate dehydrogenase family. http://togogenome.org/gene/9597:EFHB ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVE6 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9597:YME1L1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C161 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/9597:HSDL2 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z825|||http://purl.uniprot.org/uniprot/A0A2R8ZEN0 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/9597:LAMTOR4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJ39 ^@ Similarity ^@ Belongs to the LAMTOR4 family. http://togogenome.org/gene/9597:TMCO4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AHQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMCO4 family.|||Membrane http://togogenome.org/gene/9597:INSIG2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AW28 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INSIG family.|||Endoplasmic reticulum membrane|||Mediates feedback control of cholesterol synthesis.|||Membrane http://togogenome.org/gene/9597:LCA5L ^@ http://purl.uniprot.org/uniprot/A0A2R9B9U9 ^@ Similarity ^@ Belongs to the LCA5 family. http://togogenome.org/gene/9597:RSPH3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the flagellar radial spoke RSP3 family.|||flagellum axoneme http://togogenome.org/gene/9597:SKI ^@ http://purl.uniprot.org/uniprot/A0A2R9AH64 ^@ Similarity ^@ Belongs to the SKI family. http://togogenome.org/gene/9597:BLOC1S5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVX5 ^@ Similarity ^@ Belongs to the BLOC1S5 family. http://togogenome.org/gene/9597:DUSP9 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJK5 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9597:ENDOG ^@ http://purl.uniprot.org/uniprot/A0A2R9C4H9 ^@ Similarity ^@ Belongs to the DNA/RNA non-specific endonuclease family. http://togogenome.org/gene/9597:SLC12A1 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z779|||http://purl.uniprot.org/uniprot/A0A2R8Z783 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9597:CCT4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BDI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9597:PKIA ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIM0 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/9597:SULT1C2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BXP4 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9597:OPRM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C8J8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Endosome|||Membrane|||Perikaryon|||axon|||dendrite http://togogenome.org/gene/9597:PRRC1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRRC1 family.|||Golgi apparatus http://togogenome.org/gene/9597:SH3RF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SH3RF family.|||lamellipodium|||perinuclear region|||trans-Golgi network http://togogenome.org/gene/9597:WTAP ^@ http://purl.uniprot.org/uniprot/A0A2R9A685|||http://purl.uniprot.org/uniprot/A0A2R9A694 ^@ Similarity ^@ Belongs to the fl(2)d family. http://togogenome.org/gene/9597:C15H15orf40 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHU9 ^@ Similarity ^@ Belongs to the UPF0235 family. http://togogenome.org/gene/9597:TAX1BP3 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7U6 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Cytoplasm|||May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.|||Nucleus http://togogenome.org/gene/9597:ZNF136 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEJ9 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:SELP ^@ http://purl.uniprot.org/uniprot/A0A2R9AUS4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the selectin/LECAM family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:CNTN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B3B9|||http://purl.uniprot.org/uniprot/A0A2R9B741 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. Contactin family. http://togogenome.org/gene/9597:GNRHR ^@ http://purl.uniprot.org/uniprot/A0A2R9C7P5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:TEAD4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BKF7|||http://purl.uniprot.org/uniprot/A0A2R9BUD4 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. http://togogenome.org/gene/9597:NUDT12 ^@ http://purl.uniprot.org/uniprot/A0A2R9BGH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Nudix hydrolase family. NudC subfamily.|||Cytoplasmic granule|||Peroxisome http://togogenome.org/gene/9597:CST9 ^@ http://purl.uniprot.org/uniprot/A0A2R9BH73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cystatin family.|||Secreted http://togogenome.org/gene/9597:THOP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AKN5 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/9597:TAC3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tachykinin family.|||Secreted http://togogenome.org/gene/9597:PML ^@ http://purl.uniprot.org/uniprot/A0A2R9A6X2|||http://purl.uniprot.org/uniprot/A0A2R9A6Y4|||http://purl.uniprot.org/uniprot/A0A2R9A800|||http://purl.uniprot.org/uniprot/Q15JE2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:DYNC2H1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BY73|||http://purl.uniprot.org/uniprot/A0A2R9BY90 ^@ Similarity ^@ Belongs to the dynein heavy chain family. http://togogenome.org/gene/9597:POMGNT2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 61 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:CEP63 ^@ http://purl.uniprot.org/uniprot/A0A2R9B461|||http://purl.uniprot.org/uniprot/A0A2R9B465 ^@ Similarity ^@ Belongs to the CEP63 family. http://togogenome.org/gene/9597:TLR7 ^@ http://purl.uniprot.org/uniprot/B3Y649 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9597:RPL32 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDY6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/9597:ERLIN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BCK7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the band 7/mec-2 family.|||Endoplasmic reticulum membrane|||Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.|||Membrane http://togogenome.org/gene/9597:ADGRF5 ^@ http://purl.uniprot.org/uniprot/A0A2R9B2W1|||http://purl.uniprot.org/uniprot/A0A2R9B554 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Membrane http://togogenome.org/gene/9597:AQP11 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJT7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.|||Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.|||Membrane http://togogenome.org/gene/9597:GPR34 ^@ http://purl.uniprot.org/uniprot/Q3SAG9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Orphan receptor. http://togogenome.org/gene/9597:CXCR4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CH84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell junction|||Cell membrane|||Early endosome|||Endosome|||Late endosome|||Lysosome|||Membrane http://togogenome.org/gene/9597:LOC100988752 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z8K8 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Component of the small ribosomal subunit. http://togogenome.org/gene/9597:HPS3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYI6|||http://purl.uniprot.org/uniprot/A0A2R9A2W9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.|||Cytoplasm|||Involved in early stages of melanosome biogenesis and maturation. http://togogenome.org/gene/9597:LOC100970414 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7U5 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9597:KIF3C ^@ http://purl.uniprot.org/uniprot/A0A2R9BZ98 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9597:TIMM8B ^@ http://purl.uniprot.org/uniprot/A0A2R9B6T3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9597:SLC5A8 ^@ http://purl.uniprot.org/uniprot/A0A2R9BLW4 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:LOC100981014 ^@ http://purl.uniprot.org/uniprot/A0A2R9A7B2 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9597:CD99 ^@ http://purl.uniprot.org/uniprot/A0A2R9AC51 ^@ Similarity ^@ Belongs to the CD99 family. http://togogenome.org/gene/9597:ATP6AP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C0U5 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Lysosome membrane|||Membrane|||autophagosome membrane|||clathrin-coated vesicle membrane|||dendritic spine membrane|||synaptic vesicle membrane http://togogenome.org/gene/9597:ACAP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BF19 ^@ Activity Regulation|||Domain|||Function|||Subcellular Location Annotation ^@ Endosome membrane|||GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.|||GTPase-activating protein for the ADP ribosylation factor family.|||PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.|||The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions. http://togogenome.org/gene/9597:FAM221A ^@ http://purl.uniprot.org/uniprot/A0A2R9C541|||http://purl.uniprot.org/uniprot/A0A2R9C7Y7|||http://purl.uniprot.org/uniprot/A0A2R9CFM5 ^@ Similarity ^@ Belongs to the FAM221 family. http://togogenome.org/gene/9597:MMP12 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZA46 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9597:PKIB ^@ http://purl.uniprot.org/uniprot/A0A2R9C8U5|||http://purl.uniprot.org/uniprot/A0A2R9CJI2 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/9597:ST6GAL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BBT5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Golgi stack membrane|||Membrane|||Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids. http://togogenome.org/gene/9597:EAF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CK88 ^@ Similarity ^@ Belongs to the EAF family. http://togogenome.org/gene/9597:PIGO ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMP4|||http://purl.uniprot.org/uniprot/A0A2R8ZNV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:LOC100971931 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIZ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:TAAR6 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZH87 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9597:SBNO1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZN50 ^@ Similarity ^@ Belongs to the SBNO family. http://togogenome.org/gene/9597:LOC100974914 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQ27 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:CALB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CNG8 ^@ Function|||Similarity ^@ Belongs to the calbindin family.|||Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. http://togogenome.org/gene/9597:SLC39A7 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZI2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:SH2B3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C2F4 ^@ Similarity ^@ Belongs to the SH2B adapter family. http://togogenome.org/gene/9597:CASP6 ^@ http://purl.uniprot.org/uniprot/A0A2R9BHM8|||http://purl.uniprot.org/uniprot/A0A2R9BMA1 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9597:TENT5C ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMB3 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/9597:ZKSCAN4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BRT9 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9597:ABCB7 ^@ http://purl.uniprot.org/uniprot/A0A2R9AL60 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:FANCM ^@ http://purl.uniprot.org/uniprot/A0A2R9A3N5 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. http://togogenome.org/gene/9597:EIF2A ^@ http://purl.uniprot.org/uniprot/A0A2R9CKE2 ^@ Function|||Similarity ^@ Belongs to the WD repeat EIF2A family.|||Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. http://togogenome.org/gene/9597:GTF2E2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AHX4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFIIE beta subunit family.|||Nucleus|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.|||Tetramer of two alpha and two beta chains. http://togogenome.org/gene/9597:POP5 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJZ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family.|||Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.|||nucleolus http://togogenome.org/gene/9597:LMNB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intermediate filament family.|||Nucleus lamina http://togogenome.org/gene/9597:HAL ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7Z2 ^@ Similarity ^@ Belongs to the PAL/histidase family. http://togogenome.org/gene/9597:GDI2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A110 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP. http://togogenome.org/gene/9597:PAX6 ^@ http://purl.uniprot.org/uniprot/A0A2R9CK82|||http://purl.uniprot.org/uniprot/A0A2R9CMS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/9597:LOC100976386 ^@ http://purl.uniprot.org/uniprot/A0A2R9BR08 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.|||Forms a homohexamer that can probably bind six kinase subunits. http://togogenome.org/gene/9597:CHRNB2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9597:SLC51A ^@ http://purl.uniprot.org/uniprot/A0A2R9A5Y1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:KXD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CNZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KXD1 family.|||Lysosome membrane http://togogenome.org/gene/9597:RRH ^@ http://purl.uniprot.org/uniprot/A0A2R9C7I2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9597:TATDN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AMK9|||http://purl.uniprot.org/uniprot/A0A2R9AS25 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. http://togogenome.org/gene/9597:GPD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B4E1 ^@ Similarity ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/9597:TRMT2B ^@ http://purl.uniprot.org/uniprot/A0A2R9BQZ0 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:LOC100981889 ^@ http://purl.uniprot.org/uniprot/A0A2R9AR08 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9597:ZNF264 ^@ http://purl.uniprot.org/uniprot/A0A2R9C0V7 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:CALCA ^@ http://purl.uniprot.org/uniprot/A0A2R9C2C6|||http://purl.uniprot.org/uniprot/A0A2R9C976 ^@ Similarity ^@ Belongs to the calcitonin family. http://togogenome.org/gene/9597:LOC100990116 ^@ http://purl.uniprot.org/uniprot/A0A2R9BWF2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kinesin light chain family.|||Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.|||Oligomeric complex composed of two heavy chains and two light chains.|||cytoskeleton http://togogenome.org/gene/9597:APCS ^@ http://purl.uniprot.org/uniprot/A0A2R9C9Y7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pentraxin family.|||Binds 2 calcium ions per subunit.|||Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.|||Secreted http://togogenome.org/gene/9597:WEE2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJE5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.|||Binds 2 magnesium ions per subunit.|||Nucleus http://togogenome.org/gene/9597:RBM5 ^@ http://purl.uniprot.org/uniprot/A0A2R9CIG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RBM5/RBM10 family.|||Nucleus http://togogenome.org/gene/9597:PDE9A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZW91|||http://purl.uniprot.org/uniprot/A0A2R8ZYF4 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9597:NSUN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B8T9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||extracellular exosome http://togogenome.org/gene/9597:LOC106633834 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBU8 ^@ Caution|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.|||Belongs to the universal ribosomal protein uS2 family.|||Cell membrane|||Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.|||Nucleus|||Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.|||This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. http://togogenome.org/gene/9597:VCL ^@ http://purl.uniprot.org/uniprot/A0A2R9CAL0|||http://purl.uniprot.org/uniprot/A0A2R9CAL4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.|||Belongs to the vinculin/alpha-catenin family.|||Cell membrane|||Membrane|||adherens junction|||podosome http://togogenome.org/gene/9597:CENPQ ^@ http://purl.uniprot.org/uniprot/A0A2R9BPQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-Q/OKP1 family.|||Nucleus http://togogenome.org/gene/9597:CREB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CEL5|||http://purl.uniprot.org/uniprot/A0A2R9CPF8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:DDX54 ^@ http://purl.uniprot.org/uniprot/A0A2R9CAD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.|||nucleolus http://togogenome.org/gene/9597:CACFD1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCF5|||http://purl.uniprot.org/uniprot/A0A2R8ZCX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel flower family.|||Membrane http://togogenome.org/gene/9597:MMP26 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNE0 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9597:RPL38 ^@ http://purl.uniprot.org/uniprot/A0A2R9AUE2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL38 family. http://togogenome.org/gene/9597:PPP1R3C ^@ http://purl.uniprot.org/uniprot/A0A2R9CHU8 ^@ Domain|||Function|||Subunit ^@ Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.|||Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.|||The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase. http://togogenome.org/gene/9597:SUPT6H ^@ http://purl.uniprot.org/uniprot/A0A2R9BCW3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT6 family.|||Nucleus|||Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). http://togogenome.org/gene/9597:IGBP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CNN9 ^@ Similarity ^@ Belongs to the IGBP1/TAP42 family. http://togogenome.org/gene/9597:NOL6 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5Z3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NRAP family.|||Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.|||nucleolus http://togogenome.org/gene/9597:SLA ^@ http://purl.uniprot.org/uniprot/A0A2R9C909|||http://purl.uniprot.org/uniprot/A0A2R9CJR3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:LCA5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKA0 ^@ Similarity ^@ Belongs to the LCA5 family. http://togogenome.org/gene/9597:PYGL ^@ http://purl.uniprot.org/uniprot/A0A2R9BC33 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/9597:GSS ^@ http://purl.uniprot.org/uniprot/A0A2R9A4W7 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic GSH synthase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/9597:LOC100974537 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZA82 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:ARSI ^@ http://purl.uniprot.org/uniprot/A0A2R9BT80 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9597:WDR12 ^@ http://purl.uniprot.org/uniprot/A0A2R9AUR9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat WDR12/YTM1 family.|||Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.|||Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9597:LOC100993532 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX15/CtaA family.|||Membrane http://togogenome.org/gene/9597:GOLPH3L ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLPH3/VPS74 family.|||Golgi stack membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9597:SCN3B ^@ http://purl.uniprot.org/uniprot/A0A2R9AKY8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.|||Membrane|||Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. http://togogenome.org/gene/9597:PSMG1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A631 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PSMG1 family.|||Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.|||Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2.|||Cytoplasm|||Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits.|||Forms a heterodimer with psmg2. http://togogenome.org/gene/9597:CHL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CK86 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. http://togogenome.org/gene/9597:YTHDF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AVX2 ^@ Function|||Similarity ^@ Belongs to the YTHDF family.|||Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. http://togogenome.org/gene/9597:RBX1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AIH9 ^@ Similarity ^@ Belongs to the RING-box family. http://togogenome.org/gene/9597:SLC22A2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZD17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.|||Cell membrane http://togogenome.org/gene/9597:TUBA4A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZC21 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9597:KCNA10 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7H3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:PMM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B4G4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic PMM family.|||Cytoplasm|||Homodimer.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/9597:PCK1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BLN9 ^@ Similarity|||Subunit ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.|||Monomer. http://togogenome.org/gene/9597:MSMP ^@ http://purl.uniprot.org/uniprot/A0A2R9BWC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-microseminoprotein family.|||Secreted http://togogenome.org/gene/9597:PPP3CA ^@ http://purl.uniprot.org/uniprot/A0A2R9CDE3 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-2B subfamily. http://togogenome.org/gene/9597:ZFP37 ^@ http://purl.uniprot.org/uniprot/A0A2R9AB19 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:HARBI1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BD15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HARBI1 family.|||Cytoplasm|||Nucleus|||Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity. http://togogenome.org/gene/9597:YARS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BFE5 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9597:AMOT ^@ http://purl.uniprot.org/uniprot/A0A2R9BTE3 ^@ Similarity ^@ Belongs to the angiomotin family. http://togogenome.org/gene/9597:SLC26A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B339 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane|||Sodium-independent sulfate anion transporter. Can transport other anions including bicarbonate, thiosulfate and oxalate. http://togogenome.org/gene/9597:ZNF408 ^@ http://purl.uniprot.org/uniprot/A0A2R9B617 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:POP7 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIK2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone-like Alba family.|||Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA.|||Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.|||Cytoplasmic granule|||nucleolus http://togogenome.org/gene/9597:ZNF57 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZY57 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:MDM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AKK3|||http://purl.uniprot.org/uniprot/A0A2R9AKK6|||http://purl.uniprot.org/uniprot/A0A2R9APH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM1 family.|||Nucleus|||centriole http://togogenome.org/gene/9597:CEP57 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNT7 ^@ Similarity ^@ Belongs to the translokin family. http://togogenome.org/gene/9597:PCSK1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BI06 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S8 family.|||Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.|||Vesicle|||secretory vesicle http://togogenome.org/gene/9597:MRPS33 ^@ http://purl.uniprot.org/uniprot/A0A2R9CQS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS33 family.|||Mitochondrion http://togogenome.org/gene/9597:GFOD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJK1 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. http://togogenome.org/gene/9597:PNP ^@ http://purl.uniprot.org/uniprot/A0A2R8ZI70 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family.|||Homotrimer.|||The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. http://togogenome.org/gene/9597:GJB2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIA2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Beta-type (group I) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9597:LDAH ^@ http://purl.uniprot.org/uniprot/A0A2R8ZM82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. LDAH family.|||Lipid droplet http://togogenome.org/gene/9597:MAT2B ^@ http://purl.uniprot.org/uniprot/A0A2R9CM17|||http://purl.uniprot.org/uniprot/A0A2R9CM31 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.|||Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.|||Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. http://togogenome.org/gene/9597:AEBP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z8D9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||Secreted http://togogenome.org/gene/9597:RPL36A ^@ http://purl.uniprot.org/uniprot/A0A2R9BCS2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/9597:GABRB2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C809|||http://purl.uniprot.org/uniprot/A0A2R9C8C8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9597:API5 ^@ http://purl.uniprot.org/uniprot/A0A2R9B4I5 ^@ Similarity ^@ Belongs to the API5 family. http://togogenome.org/gene/9597:GABRQ ^@ http://purl.uniprot.org/uniprot/A0A2R9ALH2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9597:CPNE8 ^@ http://purl.uniprot.org/uniprot/A0A2R9CL30 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9597:CACNB3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||Cytoplasm http://togogenome.org/gene/9597:LBP ^@ http://purl.uniprot.org/uniprot/A0A2R9B8P9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.|||Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.|||Secreted|||When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14. http://togogenome.org/gene/9597:METTL16 ^@ http://purl.uniprot.org/uniprot/A0A2R9ADH3 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METTL16/RlmF family.|||RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. http://togogenome.org/gene/9597:FAM131B ^@ http://purl.uniprot.org/uniprot/A0A2R9AII7|||http://purl.uniprot.org/uniprot/A0A2R9AMC6 ^@ Similarity ^@ Belongs to the FAM131 family. http://togogenome.org/gene/9597:FAM83C ^@ http://purl.uniprot.org/uniprot/A0A2R9BT29 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9597:SLC44A2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUX2|||http://purl.uniprot.org/uniprot/A0A2R9BYB4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/9597:SF3B3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZRD4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:RAB9B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZB34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||phagosome membrane http://togogenome.org/gene/9597:MOGS ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMA7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 63 family.|||Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9597:COPE ^@ http://purl.uniprot.org/uniprot/A0A2R8ZM06|||http://purl.uniprot.org/uniprot/A0A2R8ZQ74 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPE family.|||Cytoplasm|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. http://togogenome.org/gene/9597:SYN3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AWU4 ^@ Similarity ^@ Belongs to the synapsin family. http://togogenome.org/gene/9597:ATP8B2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AX67|||http://purl.uniprot.org/uniprot/A0A2R9AX93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9597:SFTPC ^@ http://purl.uniprot.org/uniprot/A0A2R9C5L9 ^@ Function|||Subcellular Location Annotation ^@ Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.|||surface film http://togogenome.org/gene/9597:RXRG ^@ http://purl.uniprot.org/uniprot/A0A2R9AKU6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.|||Homodimer. Heterodimer; with a rar molecule.|||Nucleus|||Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. http://togogenome.org/gene/9597:C1QBP ^@ http://purl.uniprot.org/uniprot/A0A2R9AAP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAM33 family.|||Cell membrane http://togogenome.org/gene/9597:SIX2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BZP5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:MTRF1L ^@ http://purl.uniprot.org/uniprot/A0A2R9AG16|||http://purl.uniprot.org/uniprot/A0A2R9AH06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Mitochondrion http://togogenome.org/gene/9597:KCNN4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AAT6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:KRT12 ^@ http://purl.uniprot.org/uniprot/A0A2R9B0H7 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9597:SERPINB5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZM62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the serpin family. Ov-serpin subfamily.|||extracellular space http://togogenome.org/gene/9597:THNSL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C1Y1 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/9597:MRGPRF ^@ http://purl.uniprot.org/uniprot/A0A2R9A3I5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9597:KCNA2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZH38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.|||Cell membrane|||Membrane|||Presynaptic cell membrane|||Synaptic cell membrane|||lamellipodium membrane|||paranodal septate junction|||synaptosome http://togogenome.org/gene/9597:GARS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJK5 ^@ Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Homodimer. http://togogenome.org/gene/9597:SLC37A2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7H5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.|||Membrane http://togogenome.org/gene/9597:DEFB132 ^@ http://purl.uniprot.org/uniprot/A0A2R9C956 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9597:PLSCR4 ^@ http://purl.uniprot.org/uniprot/A0A2R9APN3 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/9597:CHRNA9 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZXQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9597:RBP7 ^@ http://purl.uniprot.org/uniprot/A0A2R9AR81 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9597:DNAJA2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGS7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:ERGIC3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BEJ5|||http://purl.uniprot.org/uniprot/A0A2R9BN15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/9597:LOC100986895 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGI2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:DDRGK1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AVC5 ^@ Similarity ^@ Belongs to the DDRGK1 family. http://togogenome.org/gene/9597:DUSP29 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABZ0 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/9597:ZFP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ARC8 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:THAP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQX0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the THAP1 family.|||DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.|||Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.|||nucleoplasm http://togogenome.org/gene/9597:NDC80 ^@ http://purl.uniprot.org/uniprot/A0A2R9C428 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the NDC80/HEC1 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/9597:UNC50 ^@ http://purl.uniprot.org/uniprot/A0A2R9BCN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-50 family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/9597:TAF8 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7Q1|||http://purl.uniprot.org/uniprot/A0A2R8Z7R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF8 family.|||Nucleus http://togogenome.org/gene/9597:RIPOR3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AYW6 ^@ Similarity ^@ Belongs to the RIPOR family. http://togogenome.org/gene/9597:IFT57 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZS71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFT57 family.|||cilium basal body http://togogenome.org/gene/9597:WDR24 ^@ http://purl.uniprot.org/uniprot/A0A2R9AEW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR24 family.|||Lysosome membrane http://togogenome.org/gene/9597:SH2D1A ^@ http://purl.uniprot.org/uniprot/A0A2R9BY26 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. http://togogenome.org/gene/9597:CCNYL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B0L8|||http://purl.uniprot.org/uniprot/A0A2R9B2L1 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin Y subfamily. http://togogenome.org/gene/9597:PPP1R11 ^@ http://purl.uniprot.org/uniprot/A0A2R9CI82 ^@ Subunit ^@ Interacts with TLR2 and UBE2D2. http://togogenome.org/gene/9597:ELOC ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBZ5 ^@ Similarity ^@ Belongs to the SKP1 family. http://togogenome.org/gene/9597:RPA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BVF9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.|||Belongs to the replication factor A protein 1 family.|||Component of the heterotrimeric canonical replication protein A complex (RPA).|||PML body http://togogenome.org/gene/9597:LAMC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AWQ5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||basement membrane http://togogenome.org/gene/9597:RRP15 ^@ http://purl.uniprot.org/uniprot/A0A2R9CKV5 ^@ Similarity ^@ Belongs to the RRP15 family. http://togogenome.org/gene/9597:SF3B1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B2K6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3B1 family.|||Nucleus http://togogenome.org/gene/9597:MAPK14 ^@ http://purl.uniprot.org/uniprot/A0A2R9C8T7|||http://purl.uniprot.org/uniprot/A0A2R9C8U0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9597:NMUR2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQR8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for the neuromedin-U and neuromedin-S neuropeptides. http://togogenome.org/gene/9597:ARVCF ^@ http://purl.uniprot.org/uniprot/A0A2R8ZT99 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/9597:DHX29 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7X8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.|||Belongs to the DEAD box helicase family. DEAH subfamily.|||Cytoplasm|||Part of the 43S pre-initiation complex (PIC) that contains at least Met-tRNA, EIF1, EIF1A (EIF1AX or EIF1AY), EIF2S1, EIF2S2, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L, EIF3M, DHX29 and the 40S ribosomal subunit. http://togogenome.org/gene/9597:RNASE11 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHT0 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9597:TMEM170A ^@ http://purl.uniprot.org/uniprot/A0A2R9BCJ3|||http://purl.uniprot.org/uniprot/A0A2R9BDW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM170 family.|||Membrane http://togogenome.org/gene/9597:F2R ^@ http://purl.uniprot.org/uniprot/A0A2R9B5R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:VPS18 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS18 family.|||Membrane http://togogenome.org/gene/9597:GIMAP5 ^@ http://purl.uniprot.org/uniprot/A0A2R9CC68 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9597:ATP23 ^@ http://purl.uniprot.org/uniprot/A0A2R9B683 ^@ Similarity ^@ Belongs to the peptidase M76 family. http://togogenome.org/gene/9597:BARX2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A129 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:ETF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C1R8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic release factor 1 family.|||Cytoplasm http://togogenome.org/gene/9597:LOC100976647 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPJ4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9597:EEF1AKMT3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CI70|||http://purl.uniprot.org/uniprot/A0A2R9CI74 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Mitochondrion http://togogenome.org/gene/9597:EIF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B599 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/9597:POFUT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B3F2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 68 family.|||Endoplasmic reticulum http://togogenome.org/gene/9597:S100A9 ^@ http://purl.uniprot.org/uniprot/A0A2R9A6I5 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9597:JUNB ^@ http://purl.uniprot.org/uniprot/A0A2R8ZP35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. Jun subfamily.|||Nucleus http://togogenome.org/gene/9597:RPL27 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL27 family.|||Endoplasmic reticulum|||Rough endoplasmic reticulum http://togogenome.org/gene/9597:GHSR ^@ http://purl.uniprot.org/uniprot/A0A2R9A7D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:ACTL7A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZG05 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the actin family.|||Golgi apparatus|||May play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis.|||Nucleus|||cytoskeleton http://togogenome.org/gene/9597:KCNT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ASQ1|||http://purl.uniprot.org/uniprot/A0A2R9AX18 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:POU1F1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BLP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/9597:NDUFB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CS99 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB1 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:SLC22A7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BNG5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:ATP6V0B ^@ http://purl.uniprot.org/uniprot/A0A2R9BVN4|||http://purl.uniprot.org/uniprot/A0A2R9BZ25 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9597:LOC100970534 ^@ http://purl.uniprot.org/uniprot/A0A2R9B892 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELP5 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:CREM ^@ http://purl.uniprot.org/uniprot/A0A2R9BJV5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:PGF ^@ http://purl.uniprot.org/uniprot/A0A2R9AEK8 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/9597:PDCL3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BVE8 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9597:THG1L ^@ http://purl.uniprot.org/uniprot/A0A2R9CC24 ^@ Cofactor|||Function|||Similarity ^@ Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.|||Belongs to the tRNA(His) guanylyltransferase family.|||Binds 2 magnesium ions per subunit. http://togogenome.org/gene/9597:C10H10orf53 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZX4 ^@ Similarity ^@ Belongs to the UPF0728 family. http://togogenome.org/gene/9597:CPT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BDL0 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/9597:PDGFRA ^@ http://purl.uniprot.org/uniprot/A0A2R9AK21 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.|||Membrane|||Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.|||Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. http://togogenome.org/gene/9597:GPR157 ^@ http://purl.uniprot.org/uniprot/A0A2R9AW71 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:KIF3A ^@ http://purl.uniprot.org/uniprot/A0A2R9BDL2|||http://purl.uniprot.org/uniprot/A0A2R9BKR0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9597:PIK3R1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CCM8|||http://purl.uniprot.org/uniprot/A0A2R9CCN6|||http://purl.uniprot.org/uniprot/A0A2R9CKR4 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/9597:PPFIBP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B1G1|||http://purl.uniprot.org/uniprot/A0A2R9B1G5 ^@ Similarity ^@ Belongs to the liprin family. Liprin-beta subfamily. http://togogenome.org/gene/9597:CEMIP ^@ http://purl.uniprot.org/uniprot/A0A2R9BTS9 ^@ Similarity ^@ Belongs to the CEMIP family. http://togogenome.org/gene/9597:PARP16 ^@ http://purl.uniprot.org/uniprot/A0A2R9AA47 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9597:CTNND2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AW02 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/9597:ACTN3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKX8 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/9597:LOC100993131 ^@ http://purl.uniprot.org/uniprot/A0A2R9AF88 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.|||Cell membrane|||Membrane|||Midbody|||Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. http://togogenome.org/gene/9597:ASXL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C392 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Asx family.|||Nucleus http://togogenome.org/gene/9597:TNFSF4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AKM1 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9597:HVCN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXA4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the hydrogen channel family.|||Homodimer.|||Membrane http://togogenome.org/gene/9597:TVP23A ^@ http://purl.uniprot.org/uniprot/A0A2R9B555 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP23 family.|||Membrane http://togogenome.org/gene/9597:SHOX2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKC9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:CHST8 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:CDC42EP2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHL8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system|||Probably involved in the organization of the actin cytoskeleton.|||cytoskeleton http://togogenome.org/gene/9597:YDJC ^@ http://purl.uniprot.org/uniprot/A0A2R9BHB6 ^@ Function|||Similarity ^@ Belongs to the YdjC deacetylase family.|||Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides. http://togogenome.org/gene/9597:ARAF ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFY7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. http://togogenome.org/gene/9597:ZIC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B6P4 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/9597:MRPL54 ^@ http://purl.uniprot.org/uniprot/A0A2R9CEJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL54 family.|||Mitochondrion http://togogenome.org/gene/9597:ARL3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B1Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||centrosome http://togogenome.org/gene/9597:LOC100992969 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZ24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/9597:USH2A ^@ http://purl.uniprot.org/uniprot/A0A2R9ADY7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:XRN1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBD9|||http://purl.uniprot.org/uniprot/A0A2R8ZI65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 5'-3' exonuclease family.|||Cytoplasm http://togogenome.org/gene/9597:KCNE5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNK6 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/9597:SMIM5 ^@ http://purl.uniprot.org/uniprot/A0A2R9B3M0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:FZD3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AS81 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:MTMR3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BKZ8|||http://purl.uniprot.org/uniprot/A0A2R9BR39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/9597:DRC7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BR68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC7 family.|||cilium axoneme|||flagellum|||flagellum axoneme http://togogenome.org/gene/9597:CLDN11 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNI5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9597:MIF ^@ http://purl.uniprot.org/uniprot/A0A2R9AQ00 ^@ Similarity ^@ Belongs to the MIF family. http://togogenome.org/gene/9597:MAP3K7 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZW71|||http://purl.uniprot.org/uniprot/A0A2R8ZZW1 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation.|||Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Cytoplasm http://togogenome.org/gene/9597:IFI30 ^@ http://purl.uniprot.org/uniprot/A0A2R9AX29 ^@ Similarity|||Subunit ^@ Belongs to the GILT family.|||Dimer; disulfide-linked. http://togogenome.org/gene/9597:HDHD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A4W0 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/9597:FOXP3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZXV7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:TMEM45B ^@ http://purl.uniprot.org/uniprot/A0A2R9AI60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/9597:LHFPL5 ^@ http://purl.uniprot.org/uniprot/A0A2R9AIW5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:RIGI ^@ http://purl.uniprot.org/uniprot/A0A2R9CAP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/9597:ENTPD7 ^@ http://purl.uniprot.org/uniprot/A0A2R9B779 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9597:PSMC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A6J0 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9597:NUP133 ^@ http://purl.uniprot.org/uniprot/A0A2R9B384 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin Nup133 family.|||nuclear pore complex http://togogenome.org/gene/9597:DLGAP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AP48|||http://purl.uniprot.org/uniprot/A0A2R9ATN1|||http://purl.uniprot.org/uniprot/A0A2R9AW07 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/9597:PTCD3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A0B5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS39 family.|||Mitochondrion http://togogenome.org/gene/9597:SPP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AEB6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPP2 family.|||Could coordinate an aspect of bone turnover.|||Secreted http://togogenome.org/gene/9597:ERMN ^@ http://purl.uniprot.org/uniprot/A0A2R9AT88 ^@ Function|||Subunit ^@ Binds actin.|||Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS. http://togogenome.org/gene/9597:VKORC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BGD1|||http://purl.uniprot.org/uniprot/A0A2R9BK20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VKOR family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:BANF1 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z607 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:PDE1C ^@ http://purl.uniprot.org/uniprot/A0A2R9CEK6 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9597:PCLAF ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLE4|||http://purl.uniprot.org/uniprot/A0A2R8ZRF7 ^@ Subcellular Location Annotation ^@ Nucleus|||perinuclear region http://togogenome.org/gene/9597:CLCN4 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z8M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Membrane http://togogenome.org/gene/9597:SYT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BB69 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.|||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.|||synaptic vesicle membrane http://togogenome.org/gene/9597:GDNF ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDG7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family. GDNF subfamily.|||Homodimer; disulfide-linked.|||Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.|||Secreted http://togogenome.org/gene/9597:GNAO1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7L7|||http://purl.uniprot.org/uniprot/A0A2R9CI50 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9597:DDAH1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ATQ6 ^@ Function|||Similarity ^@ Belongs to the DDAH family.|||Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. http://togogenome.org/gene/9597:TNKS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BZG6 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9597:DDI2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BMW9 ^@ Similarity ^@ Belongs to the DDI1 family. http://togogenome.org/gene/9597:CLCN5 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9A7|||http://purl.uniprot.org/uniprot/A0A2R9AD48 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.|||Cell membrane|||Endosome membrane|||Golgi apparatus membrane|||Interacts with NEDD4 and NEDD4L.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:CCBE1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AMQ9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:TSPAN31 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9597:MINAR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BXS2 ^@ Similarity ^@ Belongs to the MINAR family. http://togogenome.org/gene/9597:DKK2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BQD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/9597:TRAM1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZD13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAM family.|||Membrane http://togogenome.org/gene/9597:CHRDL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ASZ3 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9597:PPOX ^@ http://purl.uniprot.org/uniprot/A0A2R9B4Z3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.|||Binds 1 FAD per subunit.|||Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:APEX2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B6M2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Cytoplasm|||Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.|||Mitochondrion|||Nucleus|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/9597:SOST ^@ http://purl.uniprot.org/uniprot/A0A2R9C057 ^@ Similarity ^@ Belongs to the sclerostin family. http://togogenome.org/gene/9597:ZNF3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BXT6 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:PSMB2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CIW3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:ACADSB ^@ http://purl.uniprot.org/uniprot/A0A2R9BHF8 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9597:CCDC47 ^@ http://purl.uniprot.org/uniprot/A0A2R9BY68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC47 family.|||Rough endoplasmic reticulum membrane http://togogenome.org/gene/9597:CFAP298 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP298 family.|||cilium basal body http://togogenome.org/gene/9597:MTFMT ^@ http://purl.uniprot.org/uniprot/A0A2R9B368 ^@ Similarity ^@ Belongs to the Fmt family. http://togogenome.org/gene/9597:PNPO ^@ http://purl.uniprot.org/uniprot/A0A2R9BKX3 ^@ Function|||Similarity ^@ Belongs to the pyridoxamine 5'-phosphate oxidase family.|||Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). http://togogenome.org/gene/9597:SLX4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CIP7 ^@ Similarity ^@ Belongs to the SLX4 family. http://togogenome.org/gene/9597:DYNLT2B ^@ http://purl.uniprot.org/uniprot/A0A2R9AQS6 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/9597:GSN ^@ http://purl.uniprot.org/uniprot/A0A2R9AWD3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the villin/gelsolin family.|||Binds to actin and to fibronectin. Identified in a complex composed of ACTA1, COBL, GSN and TMSB4X. Interacts with the inactive form of EIF2AK2/PKR.|||Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.|||cytoskeleton http://togogenome.org/gene/9597:SLC7A13 ^@ http://purl.uniprot.org/uniprot/A0A2R9B2C4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:RHBDD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CS20 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:AQP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CFL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9597:MCM5 ^@ http://purl.uniprot.org/uniprot/A0A2R9C800 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/9597:MRPL30 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUE6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/9597:UHRF2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZWP2 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications.|||Nucleus|||The YDG domain mediates the interaction with histone H3.|||The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3). http://togogenome.org/gene/9597:RETN ^@ http://purl.uniprot.org/uniprot/A0A2R9BC99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the resistin/FIZZ family.|||Secreted http://togogenome.org/gene/9597:PLRG1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AGK3 ^@ Similarity ^@ Belongs to the WD repeat PRL1/PRL2 family. http://togogenome.org/gene/9597:POC5 ^@ http://purl.uniprot.org/uniprot/A0A2R9BIF3|||http://purl.uniprot.org/uniprot/A0A2R9BLY7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the POC5 family.|||Essential for the assembly of the distal half of centrioles, required for centriole elongation.|||centriole http://togogenome.org/gene/9597:MRPL12 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9I4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL12 family. http://togogenome.org/gene/9597:PPIL4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CL43 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.|||Nucleus|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9597:LOC100977810 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLX2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:ACSM3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BG72 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9597:RAP2B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZU86 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Palmitoylated.|||Recycling endosome membrane|||Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. http://togogenome.org/gene/9597:SNX4 ^@ http://purl.uniprot.org/uniprot/A0A2R9A0S2 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9597:YIF1B ^@ http://purl.uniprot.org/uniprot/A0A2R9ARV2|||http://purl.uniprot.org/uniprot/A0A2R9ASB7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIF1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Has a role in transport between endoplasmic reticulum and Golgi.|||Membrane http://togogenome.org/gene/9597:KRT73 ^@ http://purl.uniprot.org/uniprot/A0A2R9BRC5 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9597:PDZK1IP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ATJ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:PDYN ^@ http://purl.uniprot.org/uniprot/A0A2R9AML7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the opioid neuropeptide precursor family.|||Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin.|||Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.|||Leumorphin has a typical opioid activity and may have anti-apoptotic effect.|||Secreted http://togogenome.org/gene/9597:LOC100973450 ^@ http://purl.uniprot.org/uniprot/A0A2R9ASJ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:STX18 ^@ http://purl.uniprot.org/uniprot/A0A2R9AW89 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Endoplasmic reticulum membrane|||Membrane|||Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. http://togogenome.org/gene/9597:PKD1L3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A437 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polycystin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:LSM3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AX57 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/9597:SPATA6 ^@ http://purl.uniprot.org/uniprot/A0A2R9A2H9 ^@ Similarity ^@ Belongs to the SPATA6 family. http://togogenome.org/gene/9597:NAT9 ^@ http://purl.uniprot.org/uniprot/A0A2R9BZU6 ^@ Similarity ^@ Belongs to the acetyltransferase family. GNAT subfamily. http://togogenome.org/gene/9597:LOC100971814 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z5R5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:XRN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ATM4 ^@ Function|||Similarity ^@ Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.|||Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. http://togogenome.org/gene/9597:APTX ^@ http://purl.uniprot.org/uniprot/A0A2R9ABN2 ^@ Subcellular Location Annotation ^@ nucleolus|||nucleoplasm http://togogenome.org/gene/9597:NMT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BQM1 ^@ Function|||Similarity ^@ Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.|||Belongs to the NMT family. http://togogenome.org/gene/9597:LOC103783322 ^@ http://purl.uniprot.org/uniprot/P60181 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIII family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:LOC100985787 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZE56 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:SYNE4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AW54|||http://purl.uniprot.org/uniprot/A0A2R9AZY2 ^@ Similarity ^@ Belongs to the nesprin family. http://togogenome.org/gene/9597:NOTO ^@ http://purl.uniprot.org/uniprot/A0A2R9B8T8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:MS4A4A ^@ http://purl.uniprot.org/uniprot/A0A2R9A3J7|||http://purl.uniprot.org/uniprot/A0A2R9A7T1 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9597:HDHD3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBN3 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/9597:WNT7A ^@ http://purl.uniprot.org/uniprot/A0A2R9AAY7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9597:NAA60 ^@ http://purl.uniprot.org/uniprot/A0A2R9BVX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. NAA60 subfamily.|||Golgi apparatus membrane http://togogenome.org/gene/9597:LOC100967245 ^@ http://purl.uniprot.org/uniprot/A0A2R9AY08 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/9597:CD55 ^@ http://purl.uniprot.org/uniprot/A0A2R9BRM3|||http://purl.uniprot.org/uniprot/A0A2R9BSA1|||http://purl.uniprot.org/uniprot/A0A2R9C0P9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:TMEM147 ^@ http://purl.uniprot.org/uniprot/A0A2R9BXH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM147 family.|||Cell membrane|||Endoplasmic reticulum membrane|||Membrane|||Nucleus membrane http://togogenome.org/gene/9597:AK4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BKT1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK3 subfamily.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP/ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP/ATP hydrolysis.|||Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.|||Mitochondrion matrix|||Monomer. http://togogenome.org/gene/9597:PGGT1B ^@ http://purl.uniprot.org/uniprot/A0A2R9C2S9 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit beta family. http://togogenome.org/gene/9597:LOC100967703 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJI5 ^@ Function|||Similarity ^@ Belongs to the PET191 family.|||Involved in an early step of the mitochondrial complex IV assembly process. http://togogenome.org/gene/9597:IFNA8 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9597:KIF18A ^@ http://purl.uniprot.org/uniprot/A0A2R9B2F7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9597:CTSK ^@ http://purl.uniprot.org/uniprot/A0A2R9C710 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9597:THNSL1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAN4 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/9597:DIMT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AYI1 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. http://togogenome.org/gene/9597:NPNT ^@ http://purl.uniprot.org/uniprot/A0A2R9AYJ2|||http://purl.uniprot.org/uniprot/A0A2R9AZC1|||http://purl.uniprot.org/uniprot/A0A2R9B4L9|||http://purl.uniprot.org/uniprot/A0A2R9B4M3 ^@ Caution|||Similarity ^@ Belongs to the nephronectin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:FAM133A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJW3 ^@ Similarity ^@ Belongs to the FAM133 family. http://togogenome.org/gene/9597:ZSCAN21 ^@ http://purl.uniprot.org/uniprot/A1YG26 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||Nucleus|||Strong transcriptional activator (By similarity). Plays an important role in spermatogenesis; essential for the progression of meiotic prophase I in spermatocytes (By similarity). http://togogenome.org/gene/9597:GNPNAT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AAM1 ^@ Similarity|||Subunit ^@ Belongs to the acetyltransferase family. GNA1 subfamily.|||Homodimer. http://togogenome.org/gene/9597:PRRX1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AGJ6|||http://purl.uniprot.org/uniprot/A0A2R9AKE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/9597:FAM124B ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6X8 ^@ Similarity ^@ Belongs to the FAM124 family. http://togogenome.org/gene/9597:TEX10 ^@ http://purl.uniprot.org/uniprot/A0A2R9BF55 ^@ Similarity ^@ Belongs to the IPI1/TEX10 family. http://togogenome.org/gene/9597:CYP2G2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C0G5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9597:ABCG1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSK2|||http://purl.uniprot.org/uniprot/A0A2R8ZTR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/9597:CHRM1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHH8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. http://togogenome.org/gene/9597:SLC25A46 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9597:GTDC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZJ0 ^@ Similarity ^@ Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. http://togogenome.org/gene/9597:ARAP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C069 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:GFOD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABE3 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. http://togogenome.org/gene/9597:GPAM ^@ http://purl.uniprot.org/uniprot/A0A2R9BMB6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPAT/DAPAT family.|||Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.|||Mitochondrion outer membrane http://togogenome.org/gene/9597:ZC3H14 ^@ http://purl.uniprot.org/uniprot/A0A2R9B8Q9|||http://purl.uniprot.org/uniprot/A0A2R9B8S2|||http://purl.uniprot.org/uniprot/A0A2R9BB29|||http://purl.uniprot.org/uniprot/A0A2R9BEP3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZC3H14 family.|||Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.|||Nucleus speckle http://togogenome.org/gene/9597:GDI1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZWZ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP. http://togogenome.org/gene/9597:TPRKB ^@ http://purl.uniprot.org/uniprot/A0A2R9ALN7 ^@ Similarity ^@ Belongs to the CGI121/TPRKB family. http://togogenome.org/gene/9597:RGS9 ^@ http://purl.uniprot.org/uniprot/A0A2R9A6Z8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:CNEP1R1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZX45|||http://purl.uniprot.org/uniprot/A0A2R9A0V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNEP1R1 family.|||Cytoplasm|||Membrane|||Nucleus membrane http://togogenome.org/gene/9597:HMBOX1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTM2|||http://purl.uniprot.org/uniprot/A0A2R8ZWC2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:TM7SF3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXP7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:CRYBB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A3H6 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9597:PGLYRP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BV11 ^@ Function|||Similarity ^@ Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.|||Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. http://togogenome.org/gene/9597:AP1S1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ALL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||Membrane|||clathrin-coated pit http://togogenome.org/gene/9597:F2RL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BBE2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9597:C7 ^@ http://purl.uniprot.org/uniprot/A0A2R9AYC3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9597:VPS33B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STXBP/unc-18/SEC1 family.|||Early endosome|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||clathrin-coated vesicle http://togogenome.org/gene/9597:SCG5 ^@ http://purl.uniprot.org/uniprot/A0A2R9CFT8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.|||Belongs to the 7B2 family.|||Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.|||Secreted http://togogenome.org/gene/9597:MVD ^@ http://purl.uniprot.org/uniprot/A0A2R8ZP16 ^@ Function|||Similarity ^@ Belongs to the diphosphomevalonate decarboxylase family.|||Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis. http://togogenome.org/gene/9597:MDH2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZI0 ^@ Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 1 family.|||Homodimer. http://togogenome.org/gene/9597:ADCK2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZ50 ^@ Similarity ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family. http://togogenome.org/gene/9597:FRAS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9U7 ^@ Similarity ^@ Belongs to the FRAS1 family. http://togogenome.org/gene/9597:RABEP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BAQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rabaptin family.|||Cytoplasm|||Early endosome|||Endosome http://togogenome.org/gene/9597:BOLA2B ^@ http://purl.uniprot.org/uniprot/A0A2R9BY10 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/9597:HOXB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BS21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Labial subfamily.|||Nucleus http://togogenome.org/gene/9597:PTCD2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTCD2 family.|||Mitochondrion http://togogenome.org/gene/9597:LOC100991996 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZI62 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:TSPAN18 ^@ http://purl.uniprot.org/uniprot/A0A2R9AHT9|||http://purl.uniprot.org/uniprot/A0A2R9AMI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9597:TAF1A ^@ http://purl.uniprot.org/uniprot/A0A2R9BPT1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits.|||Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.|||Nucleus http://togogenome.org/gene/9597:MGAT1 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z919 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 13 family.|||Golgi apparatus membrane|||Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.|||Membrane|||The cofactor is mostly bound to the substrate. http://togogenome.org/gene/9597:PREPL ^@ http://purl.uniprot.org/uniprot/A0A2R9C8X9 ^@ Similarity ^@ Belongs to the peptidase S9A family. http://togogenome.org/gene/9597:RASGRP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BV52 ^@ Similarity ^@ Belongs to the RASGRP family. http://togogenome.org/gene/9597:GNMT ^@ http://purl.uniprot.org/uniprot/A0A2R8ZA16 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family. http://togogenome.org/gene/9597:GASK1B ^@ http://purl.uniprot.org/uniprot/A0A2R9B2M0 ^@ Similarity ^@ Belongs to the GASK family. http://togogenome.org/gene/9597:FAH ^@ http://purl.uniprot.org/uniprot/A0A2R9CIB9 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/9597:AKAP3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CCE9 ^@ Similarity ^@ Belongs to the AKAP110 family. http://togogenome.org/gene/9597:ANXA9 ^@ http://purl.uniprot.org/uniprot/A0A2R9B3A6 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9597:SLC25A3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A3S8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Interacts with PPIF; the interaction is impaired by CsA.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9597:CASP3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A7H9 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9597:ZZZ3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BW28 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:ZNF280C ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVK6 ^@ Function|||Subcellular Location Annotation ^@ May function as a transcription factor.|||Nucleus http://togogenome.org/gene/9597:MEF2C ^@ http://purl.uniprot.org/uniprot/A0A2R9BUT3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:INMT ^@ http://purl.uniprot.org/uniprot/A0A2R9C720 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. http://togogenome.org/gene/9597:ENPEP ^@ http://purl.uniprot.org/uniprot/A0A2R9AL64 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9597:POLR2G ^@ http://purl.uniprot.org/uniprot/A0A2R9BWD8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.|||DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/9597:ACOT13 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZQ2 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/9597:RAB27A ^@ http://purl.uniprot.org/uniprot/A0A2R9ACB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/9597:STX10 ^@ http://purl.uniprot.org/uniprot/A0A2R9CA96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Golgi apparatus membrane http://togogenome.org/gene/9597:PLCB2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BXS0|||http://purl.uniprot.org/uniprot/A0A2R9BYE2 ^@ Cofactor|||Function ^@ Binds 1 Ca(2+) ion per subunit.|||The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. http://togogenome.org/gene/9597:MDN1 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9Y1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the midasin family.|||Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9597:UGGT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 8 family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9597:RPL18 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL18 family.|||Rough endoplasmic reticulum http://togogenome.org/gene/9597:SRD5A2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ANP5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.|||Membrane|||Microsome membrane http://togogenome.org/gene/9597:BRINP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AL02 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/9597:TAS1R2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CCZ6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:TGFB3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJT4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.|||extracellular matrix http://togogenome.org/gene/9597:GATAD2A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBD1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:CDC42 ^@ http://purl.uniprot.org/uniprot/A0A2R9AF88|||http://purl.uniprot.org/uniprot/A0A2R9AG93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.|||Cell membrane|||Membrane|||Midbody|||Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. http://togogenome.org/gene/9597:LOC100986229 ^@ http://purl.uniprot.org/uniprot/A0A2R9BFK9|||http://purl.uniprot.org/uniprot/A0A2R9CE22|||http://purl.uniprot.org/uniprot/A0A2R9CM92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CELF/BRUNOL family.|||Belongs to the glycosyl hydrolase 20 family.|||Lysosome|||Nucleus http://togogenome.org/gene/9597:LOC100976596 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCU1 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:VAMP8 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9597:PRIM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B7A5 ^@ Similarity ^@ Belongs to the eukaryotic-type primase small subunit family. http://togogenome.org/gene/9597:PHC2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZL28 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:FAM110C ^@ http://purl.uniprot.org/uniprot/A0A2R9AB80 ^@ Similarity ^@ Belongs to the FAM110 family. http://togogenome.org/gene/9597:USP48 ^@ http://purl.uniprot.org/uniprot/A0A2R9A2H4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Nucleus http://togogenome.org/gene/9597:HOXC11 ^@ http://purl.uniprot.org/uniprot/A0A2R9CK06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9597:SELENBP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CG66 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the selenium-binding protein family.|||Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.|||Interacts with USP33.|||Membrane|||Nucleus|||cytosol http://togogenome.org/gene/9597:LIPA ^@ http://purl.uniprot.org/uniprot/A0A2R9BPL4 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9597:SKAP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C2D3 ^@ Similarity ^@ Belongs to the SKAP family. http://togogenome.org/gene/9597:ARRB2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BT61|||http://purl.uniprot.org/uniprot/A0A2R9BWL3 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9597:ETV1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGG3|||http://purl.uniprot.org/uniprot/A0A2R8ZGH7|||http://purl.uniprot.org/uniprot/A0A2R8ZH34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9597:EEF1A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYN3 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/9597:KHDRBS3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CT81 ^@ Similarity ^@ Belongs to the KHDRBS family. http://togogenome.org/gene/9597:CCDC39 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZX89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC39 family.|||cilium axoneme http://togogenome.org/gene/9597:CDK8 ^@ http://purl.uniprot.org/uniprot/A0A2R9B4M4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:ATP1A2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B4R7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:C2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CL13 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9597:DLGAP5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZXB4|||http://purl.uniprot.org/uniprot/A0A2R8ZZL9 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/9597:HOXC5 ^@ http://purl.uniprot.org/uniprot/A0A2R9AR67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9597:ZNF189 ^@ http://purl.uniprot.org/uniprot/A0A2R9AYB6 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:INTS9 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.|||Nucleus http://togogenome.org/gene/9597:BBS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ANA3 ^@ Subcellular Location Annotation ^@ centriolar satellite|||cilium membrane http://togogenome.org/gene/9597:LOC100986481 ^@ http://purl.uniprot.org/uniprot/G4XXM0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space|||Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. http://togogenome.org/gene/9597:CIMIP2C ^@ http://purl.uniprot.org/uniprot/A0A2R9AZY7 ^@ Similarity ^@ Belongs to the CIMIP2 family. http://togogenome.org/gene/9597:OLFML2B ^@ http://purl.uniprot.org/uniprot/A0A2R9A075 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:TAP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A6J2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.|||Membrane http://togogenome.org/gene/9597:PLET1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTB7 ^@ Function ^@ Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle. http://togogenome.org/gene/9597:MFRP ^@ http://purl.uniprot.org/uniprot/A0A2R9CJM3 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:TTC9 ^@ http://purl.uniprot.org/uniprot/A0A2R9B8P3 ^@ Similarity ^@ Belongs to the TTC9 family. http://togogenome.org/gene/9597:SLC25A45 ^@ http://purl.uniprot.org/uniprot/A0A2R9B3B5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9597:ACKR3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZE81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:ZNF679 ^@ http://purl.uniprot.org/uniprot/A0A2R9CG60 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:DCLRE1B ^@ http://purl.uniprot.org/uniprot/A0A2R9AH41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/9597:CDK4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BHC1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:PDE7B ^@ http://purl.uniprot.org/uniprot/A0A2R9BBF1|||http://purl.uniprot.org/uniprot/A0A2R9BJI2 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9597:PEPD ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZT3 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/9597:CRISP1 ^@ http://purl.uniprot.org/uniprot/A0A075IK76 ^@ Caution|||Similarity ^@ Belongs to the CRISP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:KRT7 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJ20 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9597:LOC100974357 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZII4 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:RCL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BKG8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.|||Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.|||nucleolus http://togogenome.org/gene/9597:AMPD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A5P5 ^@ Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.|||Homotetramer. http://togogenome.org/gene/9597:NHERF1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEL3 ^@ Function|||Subcellular Location Annotation ^@ Apical cell membrane|||Cell membrane|||Endomembrane system|||Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. http://togogenome.org/gene/9597:MCF2L ^@ http://purl.uniprot.org/uniprot/A0A2R9BFA8|||http://purl.uniprot.org/uniprot/A0A2R9BFB4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:METTL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CFP9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.|||Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.|||Forms a complex with WDR4.|||Nucleus|||Phosphorylation at Ser-52 inactivates its catalytic activity but does not affect the interaction with WDR4. http://togogenome.org/gene/9597:ZNF213 ^@ http://purl.uniprot.org/uniprot/A0A2R9CB24 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9597:ABCG5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/9597:ACO2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLD7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.|||Mitochondrion http://togogenome.org/gene/9597:CUEDC2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUEDC2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:TRPC3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZ30 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:PUF60 ^@ http://purl.uniprot.org/uniprot/A0A2R9A919|||http://purl.uniprot.org/uniprot/A0A2R9AA46|||http://purl.uniprot.org/uniprot/A0A2R9AEA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM half pint family.|||Nucleus http://togogenome.org/gene/9597:PLOD3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BNE3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9597:FRZB ^@ http://purl.uniprot.org/uniprot/A0A2R9ANQ8 ^@ Caution|||Function|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. http://togogenome.org/gene/9597:PSMD7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYL8 ^@ Similarity ^@ Belongs to the peptidase M67A family. http://togogenome.org/gene/9597:FTHL17 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6I8 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/9597:RPS21 ^@ http://purl.uniprot.org/uniprot/A0A2R9CIX3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS21 family.|||Component of the 40S small ribosomal subunit.|||Endoplasmic reticulum|||Rough endoplasmic reticulum|||cytosol http://togogenome.org/gene/9597:CLRN2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZV37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/9597:ILK ^@ http://purl.uniprot.org/uniprot/A0A2R9ACD3 ^@ Subcellular Location Annotation ^@ focal adhesion|||lamellipodium|||sarcomere http://togogenome.org/gene/9597:RAB5IF ^@ http://purl.uniprot.org/uniprot/A0A2R9A2P5|||http://purl.uniprot.org/uniprot/A0A2R9A3T3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMC6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:CYP4F11 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLE2 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9597:USE1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A2D6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the USE1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:SLC35A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C1A2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:CERS6 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJR2|||http://purl.uniprot.org/uniprot/A0A2R9ARW2 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9597:GLB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BMT9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 35 family. http://togogenome.org/gene/9597:EXOC3L1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZU25 ^@ Similarity ^@ Belongs to the SEC6 family. http://togogenome.org/gene/9597:TAFAZZIN ^@ http://purl.uniprot.org/uniprot/A0A2R9BCD1|||http://purl.uniprot.org/uniprot/A0A2R9BCD4|||http://purl.uniprot.org/uniprot/A0A2R9BDM2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis.|||Associates with multiple protein complexes.|||Belongs to the taffazin family.|||Mitochondrion inner membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9597:TARBP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABA8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TARBP2 family.|||Cytoplasm|||Nucleus|||Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.|||Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC).|||perinuclear region http://togogenome.org/gene/9597:LOC100980586 ^@ http://purl.uniprot.org/uniprot/A0A2R9CE33 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/9597:TONSL ^@ http://purl.uniprot.org/uniprot/A0A2R9AZE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tonsoku family.|||Chromosome http://togogenome.org/gene/9597:TRAM2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAM family.|||Membrane http://togogenome.org/gene/9597:USP30 ^@ http://purl.uniprot.org/uniprot/A0A2R9A415 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9597:HADHA ^@ http://purl.uniprot.org/uniprot/A0A2R9CMA4 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9597:XAGE3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A2R7 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9597:SH3BP5 ^@ http://purl.uniprot.org/uniprot/A0A2R9BWA7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SH3BP5 family.|||Cytoplasm|||Functions as guanine nucleotide exchange factor (GEF) for RAB11A.|||Interacts with GDP-bound and nucleotide-free forms of RAB11A.|||The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape. http://togogenome.org/gene/9597:NOP10 ^@ http://purl.uniprot.org/uniprot/A0A2R9B7C3 ^@ Similarity ^@ Belongs to the NOP10 family. http://togogenome.org/gene/9597:PCSK2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4T7 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9597:KCNH7 ^@ http://purl.uniprot.org/uniprot/A0A2R9AYY0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:NUDCD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CE81 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9597:EGFLAM ^@ http://purl.uniprot.org/uniprot/A0A2R9AZ08 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:LOC100970300 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z8Q0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9597:B3GNT8 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:PEX1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C762 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||cytosol http://togogenome.org/gene/9597:LOC100972491 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCA5 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:GABBR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CEK3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:GCNT1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZI21 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:ZC3HAV1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSP8|||http://purl.uniprot.org/uniprot/B0LB04 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9597:CLK2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJL9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:PPP1R21 ^@ http://purl.uniprot.org/uniprot/A0A2R9AKC2|||http://purl.uniprot.org/uniprot/A0A2R9AKD9 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9597:GNG7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BDV4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9597:CACNB4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZ38|||http://purl.uniprot.org/uniprot/A0A2R8ZZ57|||http://purl.uniprot.org/uniprot/A0A2R9A3E7|||http://purl.uniprot.org/uniprot/A0A2R9A4Q0 ^@ Similarity ^@ Belongs to the calcium channel beta subunit family. http://togogenome.org/gene/9597:NUP88 ^@ http://purl.uniprot.org/uniprot/A0A2R9A5T4 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/9597:PPP5C ^@ http://purl.uniprot.org/uniprot/A0A2R9BNS1 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily. http://togogenome.org/gene/9597:PATZ1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ARW0|||http://purl.uniprot.org/uniprot/A0A2R9ASE3|||http://purl.uniprot.org/uniprot/A0A2R9AYE5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:WNT2B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZR94 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9597:SPPL2A ^@ http://purl.uniprot.org/uniprot/A0A2R9A3S6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A22B family.|||Endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9597:MMS22L ^@ http://purl.uniprot.org/uniprot/A0A2R8ZT58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MMS22 family. MMS22L subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/9597:PYCR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BXA0 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/9597:DLGAP4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJB9 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/9597:RPL28 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTU0|||http://purl.uniprot.org/uniprot/A0A2R9BTV5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL28 family. http://togogenome.org/gene/9597:METAP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C140 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Binds EIF2S1 at low magnesium concentrations. Interacts strongly with the eIF-2 gamma-subunit EIF2S3.|||Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).|||Cytoplasm|||Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis. http://togogenome.org/gene/9597:WDR48 ^@ http://purl.uniprot.org/uniprot/A0A2R9ADG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR48 family.|||Late endosome http://togogenome.org/gene/9597:TIMP4 ^@ http://purl.uniprot.org/uniprot/A0A2R9B8K1 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/9597:PSMA6 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZU34 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9597:MAP3K14 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDF9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Cytoplasm|||Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. http://togogenome.org/gene/9597:FDFT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A4B7 ^@ Function|||Similarity ^@ Belongs to the phytoene/squalene synthase family.|||Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. http://togogenome.org/gene/9597:TP53 ^@ http://purl.uniprot.org/uniprot/A0A2R9A5P4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.|||Belongs to the p53 family.|||Binds 1 zinc ion per subunit.|||Binds DNA as a homotetramer.|||Cytoplasm|||Endoplasmic reticulum|||Mitochondrion matrix|||Nucleus|||PML body|||centrosome http://togogenome.org/gene/9597:AQP6 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9597:ASCC3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJM0 ^@ Similarity ^@ Belongs to the helicase family. http://togogenome.org/gene/9597:TACR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZV24 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with ARRB1.|||Membrane http://togogenome.org/gene/9597:LOC100974890 ^@ http://purl.uniprot.org/uniprot/Q69BK6 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Rieske iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster per subunit. Fe-S cluster delivery to the Rieske protein is mediated by components of the iron sulfur (Fe-S) cluster assembly machinery that reside in the mitochondrial matrix (including HSC20 and LYRM7) (By similarity).|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Incorporation of the Rieske protein UQCRFS1 is the penultimate step in complex III assembly. Interacts with TTC19, which is involved in the clearance of UQCRFS1 fragments (By similarity).|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII). Subunit 9 corresponds to the mitochondrial targeting sequence (MTS) of Rieske protein UQCRFS1. It is retained after processing and incorporated inside complex III, where it remains bound to the complex and localizes between the 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII). UQCRFS1 undergoes proteolytic processing once it is incorporated in the complex III dimer. One of the fragments, called subunit 9, corresponds to its mitochondrial targeting sequence (MTS) (By similarity). The proteolytic processing is necessary for the correct insertion of UQCRFS1 in the complex III dimer, but the persistence of UQCRFS1-derived fragments may prevent newly imported UQCRFS1 to be processed and assembled into complex III and is detrimental for the complex III structure and function (By similarity).|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. The Rieske protein is a catalytic core subunit containing a [2Fe-2S] iron-sulfur cluster. It cycles between 2 conformational states during catalysis to transfer electrons from the quinol bound in the Q(0) site in cytochrome b to cytochrome c1 (By similarity). Incorporation of UQCRFS1 is the penultimate step in complex III assembly (By similarity).|||Mitochondrion inner membrane|||Proteolytic processing is necessary for the correct insertion of UQCRFS1 in the complex III dimer. Several fragments are generated during UQCRFS1 insertion, most probably due to the endogenous matrix-processing peptidase (MPP) activity of the 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, which are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively. The action of the protease is also necessary for the clearance of the UQCRFS1 fragments.|||Several peptides are generated during UQCRFS1 insertion. According to some authors, the identification of the transit peptide as the subunit 9, does not necessary imply that it must be considered as a structural subunit of the complex III dimer as additional fragments from UQCRFS1 are also present.|||The Rieske protein is a high potential 2Fe-2S protein. http://togogenome.org/gene/9597:PPIE ^@ http://purl.uniprot.org/uniprot/A0A2R9CMW0 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.|||Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. http://togogenome.org/gene/9597:CALB2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CAC0 ^@ Function|||Similarity ^@ Belongs to the calbindin family.|||Calretinin is a calcium-binding protein which is abundant in auditory neurons. http://togogenome.org/gene/9597:GABPA ^@ http://purl.uniprot.org/uniprot/A0A2R9B7F0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9597:RNASEH1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXK0 ^@ Function|||Similarity ^@ Belongs to the RNase H family.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. http://togogenome.org/gene/9597:PPIC ^@ http://purl.uniprot.org/uniprot/A0A2R9CNV6 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9597:GCAT ^@ http://purl.uniprot.org/uniprot/A0A2R8ZU53 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9597:ZNF157 ^@ http://purl.uniprot.org/uniprot/A0A2R9CKQ3 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:LOC100982052 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:MED22 ^@ http://purl.uniprot.org/uniprot/A0A2R9CN05 ^@ Function|||Subcellular Location Annotation ^@ Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/9597:KDM4A ^@ http://purl.uniprot.org/uniprot/A0A2R9BW35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JHDM3 histone demethylase family.|||Nucleus http://togogenome.org/gene/9597:SIKE1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AKY9 ^@ Similarity ^@ Belongs to the SIKE family. http://togogenome.org/gene/9597:VPS16 ^@ http://purl.uniprot.org/uniprot/A0A2R9B9X3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS16 family.|||Early endosome|||Late endosome membrane|||Lysosome membrane|||Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.|||Vesicle http://togogenome.org/gene/9597:ATG4C ^@ http://purl.uniprot.org/uniprot/A0A2R9CGE7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/9597:DPP3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5K9 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M49 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9597:KCNJ11 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.|||Membrane http://togogenome.org/gene/9597:SLC25A20 ^@ http://purl.uniprot.org/uniprot/A0A2R9AMS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9597:SAR1B ^@ http://purl.uniprot.org/uniprot/A0A2R9ARW6 ^@ Similarity ^@ Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/9597:DCAF13 ^@ http://purl.uniprot.org/uniprot/A0A2R9AAG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat DCAF13/WDSOF1 family.|||nucleolus http://togogenome.org/gene/9597:CARTPT ^@ http://purl.uniprot.org/uniprot/A0A2R9CBD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CART family.|||Secreted http://togogenome.org/gene/9597:VPS26C ^@ http://purl.uniprot.org/uniprot/A0A2R9ABU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS26 family.|||Endosome http://togogenome.org/gene/9597:HEPH ^@ http://purl.uniprot.org/uniprot/A0A2R9BM31 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/9597:CDA ^@ http://purl.uniprot.org/uniprot/A0A2R9C9Q5 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/9597:EPN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AAA2|||http://purl.uniprot.org/uniprot/A0A2R9AAB0 ^@ Similarity ^@ Belongs to the epsin family. http://togogenome.org/gene/9597:VIPR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:MRPS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A4A5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/9597:UNG ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKC4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.|||Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.|||Mitochondrion|||Monomer. Interacts with FAM72A.|||Nucleus http://togogenome.org/gene/9597:GREM2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBR1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9597:CDH18 ^@ http://purl.uniprot.org/uniprot/A0A2R9C061 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:LOC100976433 ^@ http://purl.uniprot.org/uniprot/A0A2R9BML2 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9597:LCN12 ^@ http://purl.uniprot.org/uniprot/A0A2R9C009 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/9597:SERPINI1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSS5 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9597:EIF2S1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CGS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-2-alpha family.|||Stress granule http://togogenome.org/gene/9597:ZDHHC17 ^@ http://purl.uniprot.org/uniprot/A0A2R9AAL1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9597:NKAIN2 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NKAIN family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:GSK3B ^@ http://purl.uniprot.org/uniprot/A0A2R9C3U2|||http://purl.uniprot.org/uniprot/A0A2R9C6C8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. http://togogenome.org/gene/9597:FN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5U6|||http://purl.uniprot.org/uniprot/A0A2R9C5U9|||http://purl.uniprot.org/uniprot/A0A2R9C8N0|||http://purl.uniprot.org/uniprot/A0A2R9CGF5 ^@ Function ^@ Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling. http://togogenome.org/gene/9597:NAA38 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPZ9|||http://purl.uniprot.org/uniprot/A0A2R8ZQ06 ^@ Function|||Similarity|||Subunit ^@ Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.|||Belongs to the snRNP Sm proteins family.|||Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30. http://togogenome.org/gene/9597:SFT2D2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A4Q2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.|||Membrane http://togogenome.org/gene/9597:MOCS3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAB3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds 1 zinc ion per subunit.|||Cytoplasm|||In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.|||Interacts with NFS1.|||Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions. http://togogenome.org/gene/9597:ABHD1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZY70 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/9597:CAD ^@ http://purl.uniprot.org/uniprot/A0A2R9C7S3 ^@ Similarity ^@ In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily. http://togogenome.org/gene/9597:KCNV2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CCF3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:ITGB7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BLF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:ARSJ ^@ http://purl.uniprot.org/uniprot/A0A2R9CAG4 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9597:ZFP69B ^@ http://purl.uniprot.org/uniprot/A0A2R9C2T6 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9597:VPS35 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKL0 ^@ Function|||Similarity ^@ Belongs to the VPS35 family.|||Plays a role in vesicular protein sorting. http://togogenome.org/gene/9597:GLYR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BC40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HIBADH-related family. NP60 subfamily.|||Chromosome http://togogenome.org/gene/9597:PRPH2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B7L6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRPH2/ROM1 family.|||Membrane http://togogenome.org/gene/9597:ST6GAL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AW76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9597:MTCP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A4E0 ^@ Similarity ^@ Belongs to the TCL1 family. http://togogenome.org/gene/9597:ANK1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AEU3 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/9597:STOM ^@ http://purl.uniprot.org/uniprot/A0A2R9AUH5 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/9597:CHST4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AVP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/9597:RUNDC3B ^@ http://purl.uniprot.org/uniprot/A0A2R9B9D1|||http://purl.uniprot.org/uniprot/A0A2R9BD29 ^@ Similarity|||Subunit ^@ Belongs to the RUNDC3 family.|||Interacts with RAP2A. http://togogenome.org/gene/9597:FGF16 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZR1 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9597:NKX2-5 ^@ http://purl.uniprot.org/uniprot/A0A2R9AEW5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:TCP11L1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A136 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/9597:GAPDHS ^@ http://purl.uniprot.org/uniprot/A0A2R8Z5R8 ^@ Similarity|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/9597:GCDH ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQM3 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9597:NLRP4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AX44 ^@ Similarity ^@ Belongs to the NLRP family. http://togogenome.org/gene/9597:LOC100982404 ^@ http://purl.uniprot.org/uniprot/A0A2R9C0J2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane http://togogenome.org/gene/9597:HAT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CI44|||http://purl.uniprot.org/uniprot/A0A2R9CI71 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HAT1 family.|||Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.|||Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac). http://togogenome.org/gene/9597:BRMS1L ^@ http://purl.uniprot.org/uniprot/A0A2R9ADS1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:RPS3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A443 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS3 family.|||Membrane|||Mitochondrion inner membrane|||spindle http://togogenome.org/gene/9597:NDUFS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AMK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I 75 kDa subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:GHRL ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSX1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the motilin family.|||Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.|||O-octanoylation is essential for ghrelin activity.|||Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.|||Secreted http://togogenome.org/gene/9597:PLAA ^@ http://purl.uniprot.org/uniprot/A0A2R9C7H4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat PLAP family.|||Cytoplasm http://togogenome.org/gene/9597:PLEKHA8 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJM9|||http://purl.uniprot.org/uniprot/A0A2R9BMB7 ^@ Subcellular Location Annotation ^@ trans-Golgi network membrane http://togogenome.org/gene/9597:BBOX1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B329 ^@ Function|||Similarity ^@ Belongs to the gamma-BBH/TMLD family.|||Catalyzes the formation of L-carnitine from gamma-butyrobetaine. http://togogenome.org/gene/9597:CWC15 ^@ http://purl.uniprot.org/uniprot/A0A2R9AU78 ^@ Similarity ^@ Belongs to the CWC15 family. http://togogenome.org/gene/9597:DPH3 ^@ http://purl.uniprot.org/uniprot/A0A2R9ALH4|||http://purl.uniprot.org/uniprot/A0A2R9ALI2 ^@ Similarity ^@ Belongs to the DPH3 family. http://togogenome.org/gene/9597:OLFM2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CHF1 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/9597:GNAI2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ANZ4 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9597:HSPA13 ^@ http://purl.uniprot.org/uniprot/A0A2R9CIK6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 70 family.|||Binds UBQLN2.|||Endoplasmic reticulum|||Has peptide-independent ATPase activity.|||Microsome http://togogenome.org/gene/9597:SUDS3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BME3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:HMGCS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CGL5 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family.|||Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. http://togogenome.org/gene/9597:STXBP5L ^@ http://purl.uniprot.org/uniprot/A0A2R9BF88|||http://purl.uniprot.org/uniprot/A0A2R9BJI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat L(2)GL family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9597:DCLK1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BPD2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:MAN2B1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJC3 ^@ Cofactor|||Similarity ^@ Belongs to the glycosyl hydrolase 38 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9597:TMED10 ^@ http://purl.uniprot.org/uniprot/A0A2R9AN72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:ITPR3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C081 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the InsP3 receptor family.|||Endoplasmic reticulum membrane|||Homotetramer.|||Membrane|||Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.|||The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. http://togogenome.org/gene/9597:TEX13B ^@ http://purl.uniprot.org/uniprot/A0A2R9ATR1 ^@ Similarity ^@ Belongs to the TEX13 family. http://togogenome.org/gene/9597:HS3ST5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZRJ5 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9597:IRGC ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKF0 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. http://togogenome.org/gene/9597:LUC7L2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BL60 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/9597:ZNF556 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLP9 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:KPNA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CLZ4 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9597:EXOSC9 ^@ http://purl.uniprot.org/uniprot/A0A2R9CSV6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:ZNF687 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZXK5 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9597:PFKP ^@ http://purl.uniprot.org/uniprot/A0A2R8Z781 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homo- and heterotetramers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:ZNF707 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJN4 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:U2AF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BWJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the splicing factor SR family.|||Necessary for the splicing of pre-mRNA.|||Nucleus http://togogenome.org/gene/9597:SNX19 ^@ http://purl.uniprot.org/uniprot/A0A2R9B0F0 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9597:LOC100991415 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZN55 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:TSNAX ^@ http://purl.uniprot.org/uniprot/A0A2R9ABA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the translin family.|||Nucleus http://togogenome.org/gene/9597:PADI1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CST9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein arginine deiminase family.|||Catalyzes the deimination of arginine residues of proteins.|||Cytoplasm http://togogenome.org/gene/9597:INTS11 ^@ http://purl.uniprot.org/uniprot/A0A2R9BK81 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.|||Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.|||Nucleus http://togogenome.org/gene/9597:WDR91 ^@ http://purl.uniprot.org/uniprot/A0A2R9CLL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR91 family.|||Early endosome membrane|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9597:KLC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B9F8|||http://purl.uniprot.org/uniprot/A0A2R9B9R2|||http://purl.uniprot.org/uniprot/A0A2R9BAT1|||http://purl.uniprot.org/uniprot/A0A2R9BH40 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kinesin light chain family.|||Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.|||Oligomeric complex composed of two heavy chains and two light chains.|||cytoskeleton http://togogenome.org/gene/9597:SIX4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AAV0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:CASK ^@ http://purl.uniprot.org/uniprot/A0A2R9BZ46|||http://purl.uniprot.org/uniprot/A0A2R9C8M8 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/9597:PRR15 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6T0 ^@ Similarity ^@ Belongs to the PRR15 family. http://togogenome.org/gene/9597:PTTG1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the securin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:LOC100991769 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQ61 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:ZNF565 ^@ http://purl.uniprot.org/uniprot/A0A2R9APP1 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:LOC100971476 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTP8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:NDUFS8 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSV7 ^@ Similarity ^@ Belongs to the complex I 23 kDa subunit family. http://togogenome.org/gene/9597:CHN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AIP2 ^@ Function ^@ GTPase-activating protein for p21-rac. http://togogenome.org/gene/9597:MAP2K5 ^@ http://purl.uniprot.org/uniprot/A0A2R9BFH4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:UFD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B7J8 ^@ Similarity ^@ Belongs to the UFD1 family. http://togogenome.org/gene/9597:CDKN1B ^@ http://purl.uniprot.org/uniprot/A0A2R9A797 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/9597:NSRP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDY8 ^@ Similarity ^@ Belongs to the NSRP1 family. http://togogenome.org/gene/9597:CPSF3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CMZ9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:SUOX ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFM7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids.|||Homodimer.|||Mitochondrion intermembrane space http://togogenome.org/gene/9597:MRPL13 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJ45 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/9597:DRD5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:KPNB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A247 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the importin beta family. Importin beta-1 subfamily.|||Cytoplasm http://togogenome.org/gene/9597:MEP1B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFM8 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:SQSTM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B442 ^@ Subcellular Location Annotation ^@ Lysosome|||autophagosome http://togogenome.org/gene/9597:POLB ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGI5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||Cytoplasm|||DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.|||Nucleus http://togogenome.org/gene/9597:C1S ^@ http://purl.uniprot.org/uniprot/A0A2R9CER8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:ATXN10 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYP8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ataxin-10 family.|||Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.|||perinuclear region http://togogenome.org/gene/9597:CASP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1X3 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9597:LHCGR ^@ http://purl.uniprot.org/uniprot/A0A2R9APW3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||Membrane|||Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. http://togogenome.org/gene/9597:HNRNPA2B1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BIQ7|||http://purl.uniprot.org/uniprot/A0A2R9BRM8 ^@ Subcellular Location Annotation ^@ Cytoplasmic granule http://togogenome.org/gene/9597:GRPEL1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDN6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GrpE family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion matrix http://togogenome.org/gene/9597:MAN1A2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A2C4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9597:UXT ^@ http://purl.uniprot.org/uniprot/A0A2R9A7R1 ^@ Similarity ^@ Belongs to the UXT family. http://togogenome.org/gene/9597:PRDM1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUJ0|||http://purl.uniprot.org/uniprot/A0A2R8ZUJ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily.|||Cytoplasm|||Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.|||Nucleus|||Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions. http://togogenome.org/gene/9597:LOC100995836 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAQ6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL6 family. http://togogenome.org/gene/9597:PROKR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CMI0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9597:ATP4B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBW3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9597:C18H18orf21 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZU42 ^@ Similarity ^@ Belongs to the UPF0711 family. http://togogenome.org/gene/9597:APOA1 ^@ http://purl.uniprot.org/uniprot/P0DM91 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the apolipoprotein A1/A4/E family.|||Glycosylated.|||Homodimer (By similarity). Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1. Interacts with SCGB3A2 (By similarity). Interacts with NAXE and YJEFN3 (By similarity).|||Major protein of plasma HDL, also found in chylomicrons.|||Palmitoylated.|||Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).|||Phosphorylation sites are present in the extracellular medium.|||Secreted http://togogenome.org/gene/9597:MTRFR ^@ http://purl.uniprot.org/uniprot/A0A2R9A6Q3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Mitochondrion http://togogenome.org/gene/9597:OSBPL7 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZWM5 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9597:EGF ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6N6 ^@ Caution|||Function|||Subunit ^@ EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.|||Interacts with EGFR and promotes EGFR dimerization.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:POLR3C ^@ http://purl.uniprot.org/uniprot/A0A2R8ZRI2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/9597:SLC35A5 ^@ http://purl.uniprot.org/uniprot/A0A2R9AYE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:ATP6V0A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B4D4|||http://purl.uniprot.org/uniprot/A0A2R9B4D7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/9597:RPL36AL ^@ http://purl.uniprot.org/uniprot/A0A2R8Z918 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/9597:SULF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A7N9 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Binds 1 Ca(2+) ion per subunit.|||Cell surface|||Endoplasmic reticulum|||Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.|||Golgi stack|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9597:TMEM14B ^@ http://purl.uniprot.org/uniprot/A0A2R9AB04 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/9597:SPATA18 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQE7|||http://purl.uniprot.org/uniprot/A0A2R8ZW89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIEAP family.|||Cytoplasm|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9597:SEPTIN6 ^@ http://purl.uniprot.org/uniprot/A0A2R9C2L1|||http://purl.uniprot.org/uniprot/A0A2R9C2M1|||http://purl.uniprot.org/uniprot/A0A2R9C5L0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9597:LRRC8B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZS38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:DNAJC22 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJ38 ^@ Function|||Subcellular Location Annotation ^@ May function as a co-chaperone.|||Membrane http://togogenome.org/gene/9597:ISM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUD1 ^@ Similarity ^@ Belongs to the isthmin family. http://togogenome.org/gene/9597:MFF ^@ http://purl.uniprot.org/uniprot/A0A2R9CF37 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Tango11 family.|||Membrane|||Mitochondrion outer membrane|||Peroxisome|||Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.|||synaptic vesicle http://togogenome.org/gene/9597:IQCD ^@ http://purl.uniprot.org/uniprot/A0A2R9A4L0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC10 family.|||Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.|||flagellum axoneme http://togogenome.org/gene/9597:TRARG1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACJ5 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9597:COPZ1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B038 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes small subunit family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. http://togogenome.org/gene/9597:LOC100995379 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7D9 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:LOC100980715 ^@ http://purl.uniprot.org/uniprot/A0A2R9AU24 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:ATP6V1B1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSZ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits. http://togogenome.org/gene/9597:AACS ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEK5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Converts acetoacetate to acetoacetyl-CoA in the cytosol.|||cytosol http://togogenome.org/gene/9597:PDP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZRK3 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9597:FABP9 ^@ http://purl.uniprot.org/uniprot/A0A2R9APN4 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9597:ATP2C1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AU76 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:WDR4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BLN6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat TRM82 family.|||Nucleus|||Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. http://togogenome.org/gene/9597:RIOK3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AAJ1 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.|||Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. http://togogenome.org/gene/9597:LOC100980386 ^@ http://purl.uniprot.org/uniprot/A1YG60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9597:SLC38A2 ^@ http://purl.uniprot.org/uniprot/A1YG32 ^@ Activity Regulation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid/polyamine transporter 2 family.|||Cell membrane|||Inhibited by N-methyl-D-glucamine. Inhibited by choline. Allosteric regulation of sodium ions binding by pH.|||Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2.|||Symporter that cotransports neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane. The trasnport is pH-sensitive, Li(+)-intolerant, electrogenic, driven by the Na(+) electrochemical gradient and cotransports of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier (By similarity). May function in the transport of amino acids in the supply of maternal nutrients to the fetus through the placenta (By similarity). Maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate (By similarity). Transports L-proline in differentiating osteoblasts for the efficient synthesis of proline-enriched proteins and provides proline essential for osteoblast differentiation and bone formation during bone development (By similarity).|||The extracellular C-terminal domain controls the voltage dependence for amino acid transports activity. http://togogenome.org/gene/9597:SFN ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKA8 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9597:SERPINB11 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYQ0 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9597:HTR7 ^@ http://purl.uniprot.org/uniprot/A0A2R9C3L5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:NKIRAS2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGS1|||http://purl.uniprot.org/uniprot/A0A2R8ZHD1 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. http://togogenome.org/gene/9597:NDUFV1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CIY9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I 51 kDa subunit family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:VGLL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BF00 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs.|||Nucleus http://togogenome.org/gene/9597:PDE6C ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUN2 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9597:KDM6A ^@ http://purl.uniprot.org/uniprot/A0A2R9ADS3|||http://purl.uniprot.org/uniprot/A0A2R9ADS9|||http://purl.uniprot.org/uniprot/A0A2R9ADT5|||http://purl.uniprot.org/uniprot/A0A2R9ADU5|||http://purl.uniprot.org/uniprot/A0A2R9AEV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTX family.|||Nucleus http://togogenome.org/gene/9597:SLC2A7 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Cell membrane http://togogenome.org/gene/9597:SYF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BBH1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SYF2 family.|||Involved in pre-mRNA splicing.|||May be part of a spliceosome complex.|||Nucleus http://togogenome.org/gene/9597:EGFL8 ^@ http://purl.uniprot.org/uniprot/A0A2R9CS31 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:SEC22C ^@ http://purl.uniprot.org/uniprot/A0A2R9AFZ2|||http://purl.uniprot.org/uniprot/A0A2R9AFZ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||May be involved in vesicle transport between the ER and the Golgi complex.|||Membrane http://togogenome.org/gene/9597:HEBP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BXI3 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/9597:ZNF789 ^@ http://purl.uniprot.org/uniprot/A0A2R9C0B7|||http://purl.uniprot.org/uniprot/A0A2R9C0W9 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:CNOT8 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJP8|||http://purl.uniprot.org/uniprot/A0A2R9CJP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/9597:PARD6B ^@ http://purl.uniprot.org/uniprot/A0A2R9BQ82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAR6 family.|||Cytoplasm|||tight junction http://togogenome.org/gene/9597:STON2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQ58 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating.|||Belongs to the Stoned B family.|||Cytoplasm|||synaptosome http://togogenome.org/gene/9597:IFNA6 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9597:FBXO46 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNE1 ^@ Function ^@ Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. http://togogenome.org/gene/9597:TNRC6C ^@ http://purl.uniprot.org/uniprot/A0A2R8ZY86 ^@ Similarity ^@ Belongs to the GW182 family. http://togogenome.org/gene/9597:MYC ^@ http://purl.uniprot.org/uniprot/A1YG22 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX (By similarity). Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated at Thr-58 and Ser-62) with FBXW7. Interacts with PIM2. Interacts with RIOX1. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity. Interacts with TRIM6 (By similarity). Interacts with NPM1; the binary complex is recruited to the promoter of MYC target genes and enhances their transcription (By similarity). Interacts with CIP2A; leading to the stabilization of MYC (By similarity).|||Phosphorylated by PRKDC (By similarity). Phosphorylation at Ser-329 by PIM2 leads to the stabilization of MYC (By similarity). Phosphorylation at Ser-62 by CDK2 prevents Ras-induced senescence. Phosphorylated at Ser-62 by DYRK2; this primes the protein for subsequent phosphorylation by GSK3B at Thr-58. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome. Dephosphorylation at Ser-62 by protein phosphatase 2A (PPP2CA) promotes its degradation; interaction with PPP2CA is enhanced by AMBRA1 (By similarity).|||The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.|||Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (By similarity).|||Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. Ubiquitination is counteracted by USP28 in the nucleoplasm and USP36 in the nucleolus, both interacting with of FBXW7, leading to its deubiquitination and preventing degradation. Also polyubiquitinated by the DCX(TRPC4AP) complex. Ubiquitinated by TRIM6 in a phosphorylation-independent manner.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9597:ZNF268 ^@ http://purl.uniprot.org/uniprot/A0A2R9A8R9|||http://purl.uniprot.org/uniprot/A0A2R9A8X8 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:TFF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AA66 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:SLC30A5 ^@ http://purl.uniprot.org/uniprot/A0A2R9AVT4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Functions as a zinc transporter.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9597:P2RX6 ^@ http://purl.uniprot.org/uniprot/A0A2R9AU12 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9597:CHMP7 ^@ http://purl.uniprot.org/uniprot/A0A2R9CMM0 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9597:EEF1AKMT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B5Q5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.|||Cytoplasm|||Nucleus|||Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'. http://togogenome.org/gene/9597:LOC100984507 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYZ9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL10 family. http://togogenome.org/gene/9597:ZNF446 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSW2 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9597:PHYKPL ^@ http://purl.uniprot.org/uniprot/A0A2R9BNV3 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9597:TAP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AWW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.|||Membrane http://togogenome.org/gene/9597:LOC100967439 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9V8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9597:CAMK1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B175 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:ERI1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AV92 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:FGR ^@ http://purl.uniprot.org/uniprot/A0A2R9A4Q1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9597:EFNA3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B963 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:TAMM41 ^@ http://purl.uniprot.org/uniprot/A0A2R9BLU1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TAM41 family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:ALDH8A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A816 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9597:ZNF735 ^@ http://purl.uniprot.org/uniprot/A0A2R9AKI5 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:MRM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CQK1 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. http://togogenome.org/gene/9597:HAMP ^@ http://purl.uniprot.org/uniprot/A0A2R9BZJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hepcidin family.|||Secreted http://togogenome.org/gene/9597:WDPCP ^@ http://purl.uniprot.org/uniprot/A0A2R9APJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat fritz family.|||Cell membrane|||Membrane|||cilium axoneme http://togogenome.org/gene/9597:DDR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQ66|||http://purl.uniprot.org/uniprot/A0A2R8ZW08 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:RNASEK ^@ http://purl.uniprot.org/uniprot/A0A2R9BX52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase K family.|||Membrane http://togogenome.org/gene/9597:KDM1A ^@ http://purl.uniprot.org/uniprot/A0A2R9C9V2|||http://purl.uniprot.org/uniprot/A0A2R9CA59 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the flavin monoamine oxidase family.|||Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity.|||Nucleus|||The SWIRM domain may act as an anchor site for a histone tail. http://togogenome.org/gene/9597:THAP10 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZB70 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the THAP1 family.|||DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.|||Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.|||nucleoplasm http://togogenome.org/gene/9597:NSUN4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUP7 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/9597:MICOS10 ^@ http://purl.uniprot.org/uniprot/A0A2R9CHB8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic10 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:FAM91A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ANI6 ^@ Similarity ^@ Belongs to the FAM91 family. http://togogenome.org/gene/9597:ARL8A ^@ http://purl.uniprot.org/uniprot/A0A2R9AMN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||axon|||spindle http://togogenome.org/gene/9597:LOC100975309 ^@ http://purl.uniprot.org/uniprot/A0A2R9CHA8 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9597:STAT3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CC53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:SLC52A3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B4M5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the riboflavin transporter family.|||Cell membrane|||Membrane|||Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. http://togogenome.org/gene/9597:TAF5L ^@ http://purl.uniprot.org/uniprot/A0A2R9AYR3 ^@ Similarity ^@ Belongs to the WD repeat TAF5 family. http://togogenome.org/gene/9597:DBR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AM54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lariat debranching enzyme family.|||Nucleus http://togogenome.org/gene/9597:MTMR11 ^@ http://purl.uniprot.org/uniprot/A0A2R9AFJ1 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9597:CLDN10 ^@ http://purl.uniprot.org/uniprot/A0A2R9CSD6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9597:ARL4D ^@ http://purl.uniprot.org/uniprot/A0A2R8ZRG5 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9597:TRAF6 ^@ http://purl.uniprot.org/uniprot/A0A2R9CI00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family. A subfamily.|||Lipid droplet|||Nucleus|||cell cortex http://togogenome.org/gene/9597:RDH13 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJY5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9597:RPS24 ^@ http://purl.uniprot.org/uniprot/A0A2R9CIG7|||http://purl.uniprot.org/uniprot/A0A2R9CL49 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/9597:C1H1orf52 ^@ http://purl.uniprot.org/uniprot/A0A2R9AX40 ^@ Similarity ^@ Belongs to the UPF0690 family. http://togogenome.org/gene/9597:IYD ^@ http://purl.uniprot.org/uniprot/A0A2R9B3I3 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9597:SNRPD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CD13 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP core protein family.|||Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Component of the minor spliceosome, which splices U12-type introns. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP. Interacts (via C-terminus) with SMN1 (via Tudor domain); the interaction is direct. Interacts with GEMIN2; the interaction is direct. Interacts with SNRPD2; the interaction is direct.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.|||cytosol http://togogenome.org/gene/9597:CMC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion http://togogenome.org/gene/9597:CYP2C19 ^@ http://purl.uniprot.org/uniprot/A0A2R9B7Q9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9597:TIMP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A894 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/9597:TMED9 ^@ http://purl.uniprot.org/uniprot/A0A2R9BQE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:UBA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUW2 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/9597:SMG7 ^@ http://purl.uniprot.org/uniprot/A0A2R9AIN4 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Plays a role in nonsense-mediated mRNA decay. http://togogenome.org/gene/9597:GK5 ^@ http://purl.uniprot.org/uniprot/A0A2R9CAV2 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/9597:STX3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBH3|||http://purl.uniprot.org/uniprot/A0A2R8ZBL1|||http://purl.uniprot.org/uniprot/A0A2R8ZF33 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9597:FAM114A2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZRS0 ^@ Similarity ^@ Belongs to the FAM114 family. http://togogenome.org/gene/9597:CCHCR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZ61 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be a regulator of keratinocyte proliferation or differentiation.|||Nucleus http://togogenome.org/gene/9597:RORC ^@ http://purl.uniprot.org/uniprot/A0A2R8ZY21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9597:GTF3C5 ^@ http://purl.uniprot.org/uniprot/A0A2R9A3I3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:IPO4 ^@ http://purl.uniprot.org/uniprot/A0A2R9B574 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:G0S2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHJ6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Directly interacts with BCL2; this interaction prevents the formation of the anti-apoptotic BAX-BCL2 complex.|||Mitochondrion|||Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers. http://togogenome.org/gene/9597:P2RX4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CK77 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9597:CEP55 ^@ http://purl.uniprot.org/uniprot/A0A2R9C2I3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:LOC100971258 ^@ http://purl.uniprot.org/uniprot/A0A2R9AL68 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9597:AKAP8 ^@ http://purl.uniprot.org/uniprot/A0A2R9B909 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AKAP95 family.|||Nucleus matrix http://togogenome.org/gene/9597:SRP19 ^@ http://purl.uniprot.org/uniprot/A0A2R9BEE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP19 family.|||Cytoplasm http://togogenome.org/gene/9597:SRP9 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDL6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP9 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.|||Cytoplasm http://togogenome.org/gene/9597:CD59 ^@ http://purl.uniprot.org/uniprot/A0A2R9BGD4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:CD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AI45 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:TNFSF14 ^@ http://purl.uniprot.org/uniprot/A0A2R9BFJ8 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9597:HLF ^@ http://purl.uniprot.org/uniprot/A0A2R8ZWB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/9597:NFXL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CRL2 ^@ Similarity ^@ Belongs to the NFX1 family. http://togogenome.org/gene/9597:IP6K3 ^@ http://purl.uniprot.org/uniprot/A0A2R9ALD0 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9597:RUNX3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B517 ^@ Function|||Subcellular Location Annotation ^@ Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.|||Nucleus http://togogenome.org/gene/9597:PTGS1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUM0 ^@ Caution|||Similarity ^@ Belongs to the prostaglandin G/H synthase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:LOC100985735 ^@ http://purl.uniprot.org/uniprot/A0A2R9AUA9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:ZNF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CAP8 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:ATG2A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG2 family.|||Endoplasmic reticulum membrane|||Lipid droplet|||Preautophagosomal structure membrane http://togogenome.org/gene/9597:UBE2L3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQP0 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9597:LOC100995306 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJN8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS26 family. http://togogenome.org/gene/9597:CYP3A43 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLS0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9597:IL16 ^@ http://purl.uniprot.org/uniprot/A0A2R9BD16 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Homotetramer.|||Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.|||Nucleus|||Secreted http://togogenome.org/gene/9597:PEX13 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZY76 ^@ Similarity ^@ Belongs to the peroxin-13 family. http://togogenome.org/gene/9597:CAT ^@ http://purl.uniprot.org/uniprot/A0A2R9BSM0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the catalase family.|||Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.|||Peroxisome http://togogenome.org/gene/9597:ZSCAN10 ^@ http://purl.uniprot.org/uniprot/A0A2R9BWK2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:ORC4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CSN5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC4 family.|||Component of the origin recognition complex (ORC) that binds origins of replication.|||Nucleus http://togogenome.org/gene/9597:SURF6 ^@ http://purl.uniprot.org/uniprot/A0A2R9ARF2 ^@ Similarity ^@ Belongs to the SURF6 family. http://togogenome.org/gene/9597:AFG3L2 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z921 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/9597:LOC100981428 ^@ http://purl.uniprot.org/uniprot/A0A2R9BAN8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:GPR132 ^@ http://purl.uniprot.org/uniprot/A0A2R9C2Y5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9597:TMEM255A ^@ http://purl.uniprot.org/uniprot/A0A2R9B7X7|||http://purl.uniprot.org/uniprot/A0A2R9BF98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM255 family.|||Membrane http://togogenome.org/gene/9597:LOC100974607 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZI48 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:CD27 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJU7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:ILF3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C1L7|||http://purl.uniprot.org/uniprot/A0A2R9C1N5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9597:IFI44L ^@ http://purl.uniprot.org/uniprot/A0A2R9ALC0 ^@ Similarity ^@ Belongs to the IFI44 family. http://togogenome.org/gene/9597:RPS23 ^@ http://purl.uniprot.org/uniprot/A0A2R9CFP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS12 family.|||Rough endoplasmic reticulum http://togogenome.org/gene/9597:S100G ^@ http://purl.uniprot.org/uniprot/A0A2R9B678 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9597:QRFPR ^@ http://purl.uniprot.org/uniprot/A0A2R9C677 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9597:ATRNL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AYS8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:ANAPC16 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSH4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APC16 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|||Cytoplasm|||Nucleus|||kinetochore http://togogenome.org/gene/9597:FLNB ^@ http://purl.uniprot.org/uniprot/A0A2R9ADY8|||http://purl.uniprot.org/uniprot/A0A2R9AJ93 ^@ Similarity ^@ Belongs to the filamin family. http://togogenome.org/gene/9597:BIRC7 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVR3 ^@ Similarity ^@ Belongs to the IAP family. http://togogenome.org/gene/9597:CARMIL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BVM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CARMIL family.|||Cytoplasm http://togogenome.org/gene/9597:LOC100981154 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLT9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9597:GPR155 ^@ http://purl.uniprot.org/uniprot/A0A2R9APP0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:SLC7A3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:LOC100984164 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPX4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:SARS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BM96 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily. http://togogenome.org/gene/9597:MKNK2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7J3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:LOC100971996 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQ45 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:VWC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CMA3 ^@ Subcellular Location Annotation ^@ Synapse http://togogenome.org/gene/9597:DCTN6 ^@ http://purl.uniprot.org/uniprot/A0A2R9BDS5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.|||Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.|||cytoskeleton http://togogenome.org/gene/9597:PSME3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CT29 ^@ Similarity ^@ Belongs to the PA28 family. http://togogenome.org/gene/9597:LOC100971962 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z8X2 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:PUSL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A5N5 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/9597:TNF ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGR1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Cell membrane|||Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.|||Homotrimer. Interacts with SPPL2B.|||Membrane|||O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.|||Secreted|||The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.|||The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.|||The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space. http://togogenome.org/gene/9597:S100A8 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7E2 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9597:MCM10 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM10 family.|||Nucleus http://togogenome.org/gene/9597:ZNF620 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4H0 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:ALKBH3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A6R0 ^@ Similarity ^@ Belongs to the alkB family. http://togogenome.org/gene/9597:TAS2R13 ^@ http://purl.uniprot.org/uniprot/Q646D8 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane|||Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.|||Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). http://togogenome.org/gene/9597:PPP1R16B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZW6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:LOC100991181 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZRL0 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:GML ^@ http://purl.uniprot.org/uniprot/A0A2R9CEJ8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:FABP5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEW7 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9597:NDUFV3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFQ8|||http://purl.uniprot.org/uniprot/A0A2R8ZJ52 ^@ Function|||Similarity|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.|||Belongs to the complex I NDUFV3 subunit family.|||Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme. http://togogenome.org/gene/9597:POLE2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ATT1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase epsilon subunit B family.|||Nucleus|||Participates in DNA repair and in chromosomal DNA replication. http://togogenome.org/gene/9597:CLK4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BIW2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:HOXC9 ^@ http://purl.uniprot.org/uniprot/A0A2R9B7J5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/9597:UTP25 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP25 family.|||nucleolus http://togogenome.org/gene/9597:EIF1B ^@ http://purl.uniprot.org/uniprot/A0A2R9A346 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/9597:GPRASP3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBM1 ^@ Similarity ^@ Belongs to the GPRASP family. http://togogenome.org/gene/9597:TJP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BLV3|||http://purl.uniprot.org/uniprot/A0A2R9BLW8|||http://purl.uniprot.org/uniprot/A0A2R9BQ87|||http://purl.uniprot.org/uniprot/A0A2R9BVR0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9597:TEX261 ^@ http://purl.uniprot.org/uniprot/A0A2R9BQH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SVP26 family.|||Membrane http://togogenome.org/gene/9597:GATB ^@ http://purl.uniprot.org/uniprot/A0A2R9C802 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/9597:CYP39A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BGH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9597:RBM47 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM RBM47 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:PRKACG ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGW9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/9597:APOC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CC44 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the apolipoprotein C2 family.|||Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase.|||Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing.|||Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma.|||Secreted http://togogenome.org/gene/9597:TNFRSF10B ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6H7|||http://purl.uniprot.org/uniprot/A0A2R8Z6I2 ^@ Caution|||Function ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. http://togogenome.org/gene/9597:NQO2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGM2 ^@ Similarity ^@ Belongs to the NAD(P)H dehydrogenase (quinone) family. http://togogenome.org/gene/9597:C9H9orf78 ^@ http://purl.uniprot.org/uniprot/A0A2R9ATK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TLS1 family.|||Nucleus http://togogenome.org/gene/9597:GUK1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AGD7 ^@ Similarity ^@ Belongs to the guanylate kinase family. http://togogenome.org/gene/9597:TNS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B4X9|||http://purl.uniprot.org/uniprot/A0A2R9B4Y4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTEN phosphatase protein family.|||focal adhesion http://togogenome.org/gene/9597:SLC35B2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/9597:CD70 ^@ http://purl.uniprot.org/uniprot/A0A2R9A5Z7 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9597:PACC1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZRW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the proton-activated chloride channel family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:TSSK2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZF39 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:ASB8 ^@ http://purl.uniprot.org/uniprot/A0A2R9B7R6 ^@ Function|||Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family.|||May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/9597:FZD6 ^@ http://purl.uniprot.org/uniprot/A0A2R9B4K7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:FAM13C ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTY4 ^@ Similarity ^@ Belongs to the FAM13 family. http://togogenome.org/gene/9597:ADSL ^@ http://purl.uniprot.org/uniprot/A0A2R9AAB3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.|||Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site. http://togogenome.org/gene/9597:TIE1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BKS1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:TELO2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJG3 ^@ Similarity ^@ Belongs to the TEL2 family. http://togogenome.org/gene/9597:PARP9 ^@ http://purl.uniprot.org/uniprot/A0A2R9CL01 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9597:YPEL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQX1 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9597:TLL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BQX4 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:LOC100971782 ^@ http://purl.uniprot.org/uniprot/A0A2R9CQW6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9597:PATL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AYS4 ^@ Similarity ^@ Belongs to the PAT1 family. http://togogenome.org/gene/9597:TMC4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AC87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMC family.|||Membrane http://togogenome.org/gene/9597:CYP4F2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQU9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9597:MRGPRX4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAG2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9597:LOC100971068 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAE2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:HRH4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BQY6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9597:FLAD1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFY8 ^@ Function|||Similarity ^@ Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.|||In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.|||In the N-terminal section; belongs to the MoaB/Mog family. http://togogenome.org/gene/9597:LTBR ^@ http://purl.uniprot.org/uniprot/A0A2R9BG90 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:SLC9A4 ^@ http://purl.uniprot.org/uniprot/A0A2R9B217 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Interacts with CHP1 and CHP2.|||Membrane http://togogenome.org/gene/9597:ADGRB3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJC0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:MRPL34 ^@ http://purl.uniprot.org/uniprot/A0A2R9APJ7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/9597:EXOC7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BRH7|||http://purl.uniprot.org/uniprot/A0A2R9BRI5 ^@ Function|||Similarity ^@ Belongs to the EXO70 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/9597:CA12 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJN5|||http://purl.uniprot.org/uniprot/A0A2R9CMB8 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9597:APLP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AFK0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APP family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:MOB2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ADL9 ^@ Similarity ^@ Belongs to the MOB1/phocein family. http://togogenome.org/gene/9597:MAPK6 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUR4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9597:LOC100981677 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCQ5 ^@ Similarity ^@ Belongs to the cytochrome c oxidase VIIa family. http://togogenome.org/gene/9597:FGB ^@ http://purl.uniprot.org/uniprot/A0A2R9AN20 ^@ Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted http://togogenome.org/gene/9597:GOSR2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZF05 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOSR2 family.|||Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.|||Membrane http://togogenome.org/gene/9597:GSTCD ^@ http://purl.uniprot.org/uniprot/A0A2R9BT72 ^@ Similarity ^@ Belongs to the GSTCD family. http://togogenome.org/gene/9597:SLC49A3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4V5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:PTGES ^@ http://purl.uniprot.org/uniprot/A0A2R9AKS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Membrane http://togogenome.org/gene/9597:USP49 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNI6 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9597:SERINC4 ^@ http://purl.uniprot.org/uniprot/A0A2R9ARN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9597:DESI2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BD75 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/9597:TADA2A ^@ http://purl.uniprot.org/uniprot/A0A2R9C7T3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:TIMM21 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZH75 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM21 family.|||Component of the TIM23 complex.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion membrane|||Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes. http://togogenome.org/gene/9597:RPL23 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAM1 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/9597:STARD9 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z965 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9597:PDE4C ^@ http://purl.uniprot.org/uniprot/A0A2R9AQF7|||http://purl.uniprot.org/uniprot/A0A2R9AR23 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9597:MANBAL ^@ http://purl.uniprot.org/uniprot/A0A2R9C298 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0239 family.|||Membrane http://togogenome.org/gene/9597:C2AH2orf49 ^@ http://purl.uniprot.org/uniprot/A0A2R9A771 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ashwin family.|||Nucleus http://togogenome.org/gene/9597:AGTRAP ^@ http://purl.uniprot.org/uniprot/A0A2R9C934 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:CLCA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CPF6 ^@ Similarity ^@ Belongs to the CLCR family. http://togogenome.org/gene/9597:MON2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BC32|||http://purl.uniprot.org/uniprot/A0A2R9BKE4 ^@ Similarity ^@ Belongs to the MON2 family. http://togogenome.org/gene/9597:CFAP418 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUZ4 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in photoreceptor outer segment disk morphogenesis.|||Photoreceptor inner segment http://togogenome.org/gene/9597:VEGFD ^@ http://purl.uniprot.org/uniprot/A0A2R9C7K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDGF/VEGF growth factor family.|||Secreted http://togogenome.org/gene/9597:GRB7 ^@ http://purl.uniprot.org/uniprot/A0A2R9AMK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRB7/10/14 family.|||Cytoplasm http://togogenome.org/gene/9597:MRPL36 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJI9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/9597:TM4SF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1M1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9597:RPS9 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZG1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/9597:ACSL6 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9R9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.|||Endoplasmic reticulum membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9597:TACR3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AIG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:AKT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1U2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. http://togogenome.org/gene/9597:PIK3R3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHQ7 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/9597:DTX3L ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Deltex family.|||Cytoplasm http://togogenome.org/gene/9597:CYP46A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B9R6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9597:TSPAN19 ^@ http://purl.uniprot.org/uniprot/A0A2R9CAP1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:ZNF229 ^@ http://purl.uniprot.org/uniprot/A0A2R9B887 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:FGF5 ^@ http://purl.uniprot.org/uniprot/A0A2R9AH42|||http://purl.uniprot.org/uniprot/A0A2R9ALV2 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9597:SPPL2C ^@ http://purl.uniprot.org/uniprot/A0A2R8ZT11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A22B family.|||Membrane http://togogenome.org/gene/9597:SAA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C1G3 ^@ Function|||Similarity ^@ Belongs to the SAA family.|||Major acute phase reactant. Apolipoprotein of the HDL complex. http://togogenome.org/gene/9597:DSG4 ^@ http://purl.uniprot.org/uniprot/A0A2R9C3N0|||http://purl.uniprot.org/uniprot/A0A2R9C6L3 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.|||Membrane|||desmosome http://togogenome.org/gene/9597:ARPC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BBC8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC2 family.|||Cell projection|||Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton|||synaptosome http://togogenome.org/gene/9597:INSIG1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BF15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INSIG family.|||Endoplasmic reticulum membrane|||Mediates feedback control of cholesterol synthesis.|||Membrane http://togogenome.org/gene/9597:GRP ^@ http://purl.uniprot.org/uniprot/A0A2R9CG81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bombesin/neuromedin-B/ranatensin family.|||Secreted|||neuron projection http://togogenome.org/gene/9597:VGLL3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CIY7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs.|||Nucleus http://togogenome.org/gene/9597:FER1L6 ^@ http://purl.uniprot.org/uniprot/A0A2R9ALK2 ^@ Similarity ^@ Belongs to the ferlin family. http://togogenome.org/gene/9597:GRAMD1A ^@ http://purl.uniprot.org/uniprot/A0A2R9BW77 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:CDCA7 ^@ http://purl.uniprot.org/uniprot/A0A2R9CD76|||http://purl.uniprot.org/uniprot/A0A2R9CD81 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9597:PPP6R3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C1Z9|||http://purl.uniprot.org/uniprot/A0A2R9C210|||http://purl.uniprot.org/uniprot/A0A2R9CCA3 ^@ Similarity ^@ Belongs to the SAPS family. http://togogenome.org/gene/9597:USP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZC2 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9597:TNFRSF10C ^@ http://purl.uniprot.org/uniprot/A0A2R9AA07 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:ELOVL7 ^@ http://purl.uniprot.org/uniprot/A0A2R9CE84 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL7 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Membrane|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9597:TGIF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXU2|||http://purl.uniprot.org/uniprot/A0A2R9B1K8|||http://purl.uniprot.org/uniprot/A0A2R9B3I5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:CTSE ^@ http://purl.uniprot.org/uniprot/A0A2R9BHN9|||http://purl.uniprot.org/uniprot/A0A2R9BIL0 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/9597:ATP9B ^@ http://purl.uniprot.org/uniprot/A0A2R9B240|||http://purl.uniprot.org/uniprot/A0A2R9B422 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9597:TOR1B ^@ http://purl.uniprot.org/uniprot/A0A2R9ADY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ClpA/ClpB family. Torsin subfamily.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9597:CHST10 ^@ http://purl.uniprot.org/uniprot/A0A2R9C1M3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:KCND1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B401 ^@ Subcellular Location Annotation ^@ Membrane|||dendrite http://togogenome.org/gene/9597:SLC16A12 ^@ http://purl.uniprot.org/uniprot/A0A2R9BIE1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:EMP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AAF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/9597:NUMB ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKS8|||http://purl.uniprot.org/uniprot/A0A2R8ZNL0|||http://purl.uniprot.org/uniprot/A0A2R8ZRV2 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Plays a role in the process of neurogenesis. http://togogenome.org/gene/9597:PGLYRP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXV5 ^@ Similarity ^@ Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. http://togogenome.org/gene/9597:BTNL3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AMI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Membrane http://togogenome.org/gene/9597:P2RY2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:IMP3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZH97 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/9597:YIPF4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AL91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:REM2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C582 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9597:FAM163A ^@ http://purl.uniprot.org/uniprot/A0A2R9B445 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM163 family.|||Membrane http://togogenome.org/gene/9597:EIF4E ^@ http://purl.uniprot.org/uniprot/A0A2R9CSB0 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/9597:EPHA2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBI9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:EDIL3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B167|||http://purl.uniprot.org/uniprot/A0A2R9B1E7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:HBM ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJR3 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9597:FPR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:TIMM17B ^@ http://purl.uniprot.org/uniprot/A0A2R9BCR4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9597:TMSB15A ^@ http://purl.uniprot.org/uniprot/A0A2R9CQD8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/9597:RPL34 ^@ http://purl.uniprot.org/uniprot/A0A2R9B8N6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/9597:EMP3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CBG2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Probably involved in cell proliferation and cell-cell interactions. http://togogenome.org/gene/9597:CAVIN3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CF66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/9597:PLA2G4A ^@ http://purl.uniprot.org/uniprot/A0A2R9CGU6 ^@ Domain ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding. http://togogenome.org/gene/9597:DCLK2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C3Z7|||http://purl.uniprot.org/uniprot/A0A2R9CEE0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9597:ITPRIPL2 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z835 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITPRIP family.|||Membrane http://togogenome.org/gene/9597:PYCR2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABC1 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/9597:LOC100975217 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEF7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:WAS ^@ http://purl.uniprot.org/uniprot/A0A2R9AUP0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:GALC ^@ http://purl.uniprot.org/uniprot/A0A2R9AG83|||http://purl.uniprot.org/uniprot/A0A2R9AL28 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 59 family. http://togogenome.org/gene/9597:TIMM13 ^@ http://purl.uniprot.org/uniprot/A0A2R9B7J4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9597:MS4A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BLG9 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9597:ATP5F1A ^@ http://purl.uniprot.org/uniprot/A0A2R9AEQ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/9597:LOC100978606 ^@ http://purl.uniprot.org/uniprot/A0A2R9BZY3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9597:MOB3C ^@ http://purl.uniprot.org/uniprot/A0A2R9CFE6 ^@ Similarity ^@ Belongs to the MOB1/phocein family. http://togogenome.org/gene/9597:DYNC2LI1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BAK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light intermediate chain family.|||centrosome|||cilium|||cilium axoneme|||cilium basal body http://togogenome.org/gene/9597:FUNDC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A2M4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FUN14 family.|||Mitochondrion outer membrane http://togogenome.org/gene/9597:NPM3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C0F3 ^@ Similarity ^@ Belongs to the nucleoplasmin family. http://togogenome.org/gene/9597:LOC100988969 ^@ http://purl.uniprot.org/uniprot/A0A2R9A967 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL53 family.|||Mitochondrion http://togogenome.org/gene/9597:CACNG5 ^@ http://purl.uniprot.org/uniprot/A0A2R9C1U1 ^@ Similarity ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. http://togogenome.org/gene/9597:LOC100995326 ^@ http://purl.uniprot.org/uniprot/A0A2R9AG50 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transferrin family.|||Monomer.|||Secreted|||Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. http://togogenome.org/gene/9597:LOC100981824 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZRP3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9597:CNKSR2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BGL9|||http://purl.uniprot.org/uniprot/A0A2R9BP65 ^@ Similarity ^@ Belongs to the CNKSR family. http://togogenome.org/gene/9597:ZNF766 ^@ http://purl.uniprot.org/uniprot/A0A2R9BK10 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:BTAF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CL47 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:QTRT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYF8|||http://purl.uniprot.org/uniprot/A0A2R9C4T1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.|||Mitochondrion outer membrane|||Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). http://togogenome.org/gene/9597:RPL17 ^@ http://purl.uniprot.org/uniprot/A0A2R9A214 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/9597:SLC25A18 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9597:PFN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4K5 ^@ Similarity ^@ Belongs to the profilin family. http://togogenome.org/gene/9597:SLC17A5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTZ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:ERG28 ^@ http://purl.uniprot.org/uniprot/A0A2R9BU36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG28 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:FAM216B ^@ http://purl.uniprot.org/uniprot/A0A2R8Z672 ^@ Similarity ^@ Belongs to the FAM216 family. http://togogenome.org/gene/9597:ERMP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5F1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:RABGGTB ^@ http://purl.uniprot.org/uniprot/A0A2R9AUI7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit beta family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX. http://togogenome.org/gene/9597:BACE1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BN30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Endosome|||Membrane|||Membrane raft|||Recycling endosome|||trans-Golgi network http://togogenome.org/gene/9597:SLC13A2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/9597:CKAP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZI9 ^@ Similarity ^@ Belongs to the CKAP2 family. http://togogenome.org/gene/9597:P2RX7 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZH19 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P2X receptor family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9597:ZFP92 ^@ http://purl.uniprot.org/uniprot/A0A2R9A217 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:LOC100984553 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJ06 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIII family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9597:SLC2A6 ^@ http://purl.uniprot.org/uniprot/A0A2R9BLP3 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/9597:SEC22A ^@ http://purl.uniprot.org/uniprot/A0A2R9AA87 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||May be involved in vesicle transport between the ER and the Golgi complex.|||Membrane http://togogenome.org/gene/9597:ZSCAN20 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZK93 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9597:ADM ^@ http://purl.uniprot.org/uniprot/A0A2R8Z703 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adrenomedullin family.|||Secreted http://togogenome.org/gene/9597:NCSTN ^@ http://purl.uniprot.org/uniprot/A0A2R9ATE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nicastrin family.|||Membrane http://togogenome.org/gene/9597:COQ8B ^@ http://purl.uniprot.org/uniprot/A0A2R9ANL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family.|||Membrane http://togogenome.org/gene/9597:ZDHHC7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTJ2 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9597:MBTPS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CLP8 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9597:SCNN1G ^@ http://purl.uniprot.org/uniprot/A0A2R8ZRP1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:NDUFB8 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUX6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB8 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:DRGX ^@ http://purl.uniprot.org/uniprot/A0A2R8ZN19 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:FUT10 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZ64 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Membrane|||Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. http://togogenome.org/gene/9597:GALNT3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BCK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:SLC1A1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9597:TNFAIP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZN02 ^@ Similarity ^@ Belongs to the BACURD family. http://togogenome.org/gene/9597:CNTF ^@ http://purl.uniprot.org/uniprot/A0A2R9C1K8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNTF family.|||CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.|||Cytoplasm http://togogenome.org/gene/9597:ZNF566 ^@ http://purl.uniprot.org/uniprot/A0A2R9CHP8 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:TTC39B ^@ http://purl.uniprot.org/uniprot/A0A2R9ACE5 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/9597:NOP56 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZU94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP5/NOP56 family.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9597:MRPS10 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS10 family.|||Mitochondrion http://togogenome.org/gene/9597:ZNF630 ^@ http://purl.uniprot.org/uniprot/A0A2R9BA56 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:WDR82 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SWD2 family.|||Nucleus http://togogenome.org/gene/9597:PHKB ^@ http://purl.uniprot.org/uniprot/A0A2R9B2B7|||http://purl.uniprot.org/uniprot/A0A2R9B3W5|||http://purl.uniprot.org/uniprot/A0A2R9B406 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphorylase b kinase regulatory chain family.|||Cell membrane|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.|||Membrane|||Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. http://togogenome.org/gene/9597:CDKN1A ^@ http://purl.uniprot.org/uniprot/A0A2R9BI00 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/9597:HOMER3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BIP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Homer family.|||Cytoplasm|||Postsynaptic density|||Synapse http://togogenome.org/gene/9597:PSMD9 ^@ http://purl.uniprot.org/uniprot/A0A2R9A0N0 ^@ Similarity ^@ Belongs to the proteasome subunit p27 family. http://togogenome.org/gene/9597:IL21 ^@ http://purl.uniprot.org/uniprot/A0A2R9BR35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Secreted http://togogenome.org/gene/9597:AFF4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJU9 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/9597:SUSD5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKE8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:LAPTM4A ^@ http://purl.uniprot.org/uniprot/A0A2R9BEG7 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/9597:MRPS5 ^@ http://purl.uniprot.org/uniprot/A0A2R9BX26 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS5 family. http://togogenome.org/gene/9597:MYG1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C926 ^@ Similarity ^@ Belongs to the MYG1 family. http://togogenome.org/gene/9597:ACAT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJL2 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/9597:EPHB4 ^@ http://purl.uniprot.org/uniprot/A0A2R9B3J8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:COL4A4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BIA2 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.|||basement membrane http://togogenome.org/gene/9597:MIS12 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9A0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mis12 family.|||Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3, CBX5, NDC80 and ZWINT.|||kinetochore http://togogenome.org/gene/9597:PAIP2B ^@ http://purl.uniprot.org/uniprot/A0A2R9BIB4 ^@ Similarity ^@ Belongs to the PAIP2 family. http://togogenome.org/gene/9597:MMRN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CCC2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:TMEM150A ^@ http://purl.uniprot.org/uniprot/A0A2R9A7Y7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:AAR2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BNJ1 ^@ Function|||Similarity ^@ Belongs to the AAR2 family.|||Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. http://togogenome.org/gene/9597:FIS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BAE7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FIS1 family.|||Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.|||Membrane|||Mitochondrion outer membrane|||The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission. http://togogenome.org/gene/9597:ZNF485 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZR33 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:CDH20 ^@ http://purl.uniprot.org/uniprot/A0A2R9ARR9 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:FBXO32 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCU0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:HK1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7F8 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/9597:OSM ^@ http://purl.uniprot.org/uniprot/A0A2R9A1R8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LIF/OSM family.|||Secreted http://togogenome.org/gene/9597:THYN1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTM6 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. http://togogenome.org/gene/9597:CROT ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZX5 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/9597:CRH ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Secreted http://togogenome.org/gene/9597:LOC100995577 ^@ http://purl.uniprot.org/uniprot/A0A2R9AKD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MHC class II family.|||Endosome membrane|||Lysosome membrane http://togogenome.org/gene/9597:LOC100978430 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9P7 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9597:KIF6 ^@ http://purl.uniprot.org/uniprot/A0A2R9BL69 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9597:ATAT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACX9|||http://purl.uniprot.org/uniprot/A0A2R9AD03|||http://purl.uniprot.org/uniprot/A0A2R9ADW2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Autoacetylation strongly increases tubulin acetylation.|||Belongs to the acetyltransferase ATAT1 family.|||Component of the BBSome complex. Interacts with AP2 alpha-adaptins, including AP2A2, but not with AP1 gamma-adaptin (AP1G1/AP1G2); this interaction is required for efficient alpha-tubulin acetylation, hence clathrin-coated pits are sites of microtubule acetylation.|||Cytoplasm|||Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.|||axon|||clathrin-coated pit|||cytoskeleton|||focal adhesion|||spindle http://togogenome.org/gene/9597:AKR1A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the aldo/keto reductase family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/9597:CCL16 ^@ http://purl.uniprot.org/uniprot/A0A2R9BC38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9597:AGL ^@ http://purl.uniprot.org/uniprot/A0A2R9BB14 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycogen debranching enzyme family.|||Cytoplasm|||Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. http://togogenome.org/gene/9597:LOC100992822 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZN98 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9597:LOC100969533 ^@ http://purl.uniprot.org/uniprot/A0A2R9AFU1 ^@ Similarity ^@ Belongs to the histone H2B family. http://togogenome.org/gene/9597:OPRK1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZC4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.|||Interacts with NHERF1. Interacts with GABARAPL1.|||Membrane http://togogenome.org/gene/9597:HEBP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C6L5 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/9597:MS4A10 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9Y9 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9597:RNPEP ^@ http://purl.uniprot.org/uniprot/A0A2R9BNE8 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9597:DSTN ^@ http://purl.uniprot.org/uniprot/A0A2R9CF75 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. http://togogenome.org/gene/9597:RUSF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BAX6 ^@ Similarity ^@ Belongs to the RUS1 family. http://togogenome.org/gene/9597:RANGRF ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQT8 ^@ Similarity ^@ Belongs to the MOG1 family. http://togogenome.org/gene/9597:SLC11A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B2T1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NRAMP family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/9597:NBN ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPC7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.|||Component of the MRN complex.|||Nucleus|||telomere http://togogenome.org/gene/9597:PSIP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HDGF family.|||Nucleus http://togogenome.org/gene/9597:LCE3B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNN4 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9597:LEAP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJ48 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LEAP2 family.|||Has an antimicrobial activity.|||Secreted http://togogenome.org/gene/9597:CAMK4 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7Q5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:GAR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEA1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GAR1 family.|||Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).|||Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.|||nucleolus http://togogenome.org/gene/9597:TGFB2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACA0|||http://purl.uniprot.org/uniprot/A0A2R9AD99 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.|||extracellular matrix http://togogenome.org/gene/9597:POLG2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AS12 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9597:GMFG ^@ http://purl.uniprot.org/uniprot/A0A2R9BS29 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. GMF subfamily. http://togogenome.org/gene/9597:TUBB1 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z962 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9597:GRIN2B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSD1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/9597:B3GNT9 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:ABT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CNU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESF2/ABP1 family.|||nucleolus http://togogenome.org/gene/9597:NAALADL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CKJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:MKX ^@ http://purl.uniprot.org/uniprot/A0A2R9C923 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:APOA5 ^@ http://purl.uniprot.org/uniprot/A0A2R9C0K9 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/9597:GPC3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZID5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/9597:NAPSA ^@ http://purl.uniprot.org/uniprot/A0A2R9BGN3 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/9597:PHKG2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B805 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily.|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin. http://togogenome.org/gene/9597:NT5C3A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZS77|||http://purl.uniprot.org/uniprot/A0A2R8ZWV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrimidine 5'-nucleotidase family.|||Cytoplasm http://togogenome.org/gene/9597:ARPC1A ^@ http://purl.uniprot.org/uniprot/A0A2R9AR18 ^@ Function|||Similarity ^@ Belongs to the WD repeat ARPC1 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. http://togogenome.org/gene/9597:MRPS30 ^@ http://purl.uniprot.org/uniprot/A0A2R9AC55 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9597:IRAK4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZXJ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.|||Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.|||Cytoplasm|||Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. http://togogenome.org/gene/9597:ORC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AA19 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC2 family.|||Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.|||Component of the origin recognition complex (ORC).|||Nucleus http://togogenome.org/gene/9597:PSMB11 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z8M2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:NLGN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:RPS8 ^@ http://purl.uniprot.org/uniprot/A0A2R9BHB1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS8 family. http://togogenome.org/gene/9597:SYNPR ^@ http://purl.uniprot.org/uniprot/A0A2R9BE73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/9597:CCN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BFM8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9597:PSEN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AA90 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A22A family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Homodimer.|||Membrane|||Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.|||The PAL motif is required for normal active site conformation. http://togogenome.org/gene/9597:RXRB ^@ http://purl.uniprot.org/uniprot/A0A2R9BXU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Nucleus http://togogenome.org/gene/9597:MACIR ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UNC119-binding protein family.|||Cytoplasm|||cilium http://togogenome.org/gene/9597:DEFB118 ^@ http://purl.uniprot.org/uniprot/A0A2R9A578 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9597:TALDO1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ARX4 ^@ Function|||Similarity ^@ Belongs to the transaldolase family. Type 1 subfamily.|||Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate. http://togogenome.org/gene/9597:RNF170 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMV7 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:KIF16B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGR0|||http://purl.uniprot.org/uniprot/A0A2R8ZK03 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9597:BCAR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AR95|||http://purl.uniprot.org/uniprot/A0A2R9AXT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAS family.|||focal adhesion http://togogenome.org/gene/9597:TULP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ADG5 ^@ Similarity ^@ Belongs to the TUB family. http://togogenome.org/gene/9597:ACSL5 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7G2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion outer membrane http://togogenome.org/gene/9597:TMEM198 ^@ http://purl.uniprot.org/uniprot/A0A2R9A0U9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM198 family.|||Membrane http://togogenome.org/gene/9597:TRPC6 ^@ http://purl.uniprot.org/uniprot/A0A2R9A5Z2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:LOC100971427 ^@ http://purl.uniprot.org/uniprot/A0A2R9AML4 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:LOC100967430 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJC8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:BCKDK ^@ http://purl.uniprot.org/uniprot/A0A2R9A9S3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9597:GPR20 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDI5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9597:TTI2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AS10|||http://purl.uniprot.org/uniprot/A0A2R9AVY1 ^@ Similarity ^@ Belongs to the TTI2 family. http://togogenome.org/gene/9597:LOC100989831 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJJ5 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:MAOB ^@ http://purl.uniprot.org/uniprot/A0A2R9AU54 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/9597:LOC100978774 ^@ http://purl.uniprot.org/uniprot/A0A2R9AFZ9 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9597:HOXD10 ^@ http://purl.uniprot.org/uniprot/A0A2R9B8B4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9597:ASIP ^@ http://purl.uniprot.org/uniprot/Q1XGV6 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).|||Secreted|||The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. http://togogenome.org/gene/9597:GRN ^@ http://purl.uniprot.org/uniprot/A0A2R9AWY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the granulin family.|||Secreted http://togogenome.org/gene/9597:CDK9 ^@ http://purl.uniprot.org/uniprot/A0A2R9B5G9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:NOL11 ^@ http://purl.uniprot.org/uniprot/A0A2R9AW31 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9597:C2AH2orf68 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZS34 ^@ Similarity ^@ Belongs to the UPF0561 family. http://togogenome.org/gene/9597:SLC39A6 ^@ http://purl.uniprot.org/uniprot/A0A2R9A211 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:PIGG ^@ http://purl.uniprot.org/uniprot/A0A2R9A5W5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:GADD45G ^@ http://purl.uniprot.org/uniprot/A0A2R9A4M5 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/9597:DPCD ^@ http://purl.uniprot.org/uniprot/A0A2R9BL51 ^@ Similarity ^@ Belongs to the DPCD family. http://togogenome.org/gene/9597:SKP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDZ3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SKP1 family.|||Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit.|||Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1.|||The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. http://togogenome.org/gene/9597:ACTRT1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPK0 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9597:IFNG ^@ http://purl.uniprot.org/uniprot/A0A2R9CC85 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II (or gamma) interferon family.|||Homodimer.|||Secreted|||Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL. Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation. http://togogenome.org/gene/9597:DMC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BVM3|||http://purl.uniprot.org/uniprot/A0A2R9BW93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. DMC1 subfamily.|||May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.|||Nucleus http://togogenome.org/gene/9597:CPA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CD62 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9597:CRIPT ^@ http://purl.uniprot.org/uniprot/A0A2R8ZXF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRIPT family.|||Cytoplasm http://togogenome.org/gene/9597:YWHAB ^@ http://purl.uniprot.org/uniprot/A0A2R9BJ33 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9597:ANXA7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJM4|||http://purl.uniprot.org/uniprot/A0A2R9BN76 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9597:EMC6 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPJ3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC6 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:G6PD ^@ http://purl.uniprot.org/uniprot/A0A2R9A9Q3 ^@ Function|||Similarity ^@ Belongs to the glucose-6-phosphate dehydrogenase family.|||Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. http://togogenome.org/gene/9597:CLTRN ^@ http://purl.uniprot.org/uniprot/A0A2R9A7Z1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:CPN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CHK1 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9597:NADK ^@ http://purl.uniprot.org/uniprot/A0A2R9AMP6 ^@ Similarity ^@ Belongs to the NAD kinase family. http://togogenome.org/gene/9597:CSTA ^@ http://purl.uniprot.org/uniprot/A0A2R9CEC6 ^@ Similarity ^@ Belongs to the cystatin family. http://togogenome.org/gene/9597:MGST2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B5L7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:RSBN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A297 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the round spermatid basic protein 1 family.|||Nucleus http://togogenome.org/gene/9597:RAB27B ^@ http://purl.uniprot.org/uniprot/A0A2R9BMZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/9597:LOC100979108 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZB51|||http://purl.uniprot.org/uniprot/A0A2R8ZB67|||http://purl.uniprot.org/uniprot/A0A2R8ZB71|||http://purl.uniprot.org/uniprot/A0A2R8ZBA4|||http://purl.uniprot.org/uniprot/A0A2R8ZBU7|||http://purl.uniprot.org/uniprot/A0A2R8ZF55 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. http://togogenome.org/gene/9597:SEC62 ^@ http://purl.uniprot.org/uniprot/A0A2R9BU28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC62 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:DEGS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:FAM98C ^@ http://purl.uniprot.org/uniprot/A0A2R9CHR7 ^@ Similarity ^@ Belongs to the FAM98 family. http://togogenome.org/gene/9597:TUT7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BNW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B-like family.|||Cytoplasm http://togogenome.org/gene/9597:CENPU ^@ http://purl.uniprot.org/uniprot/A0A2R9C716 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-U/AME1 family.|||Nucleus http://togogenome.org/gene/9597:MBOAT7 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQ32 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:CDK3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSE8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:LOC100972936 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZE68 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:COG4 ^@ http://purl.uniprot.org/uniprot/A0A2R9A7R7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG4 family.|||Golgi apparatus membrane http://togogenome.org/gene/9597:RAB39B ^@ http://purl.uniprot.org/uniprot/A0A2R9C4X7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:LOC100974311 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZE83 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:NR2E1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9597:NID1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXE3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/9597:FAM124A ^@ http://purl.uniprot.org/uniprot/A0A2R9BL58 ^@ Similarity ^@ Belongs to the FAM124 family. http://togogenome.org/gene/9597:HPDL ^@ http://purl.uniprot.org/uniprot/A0A2R8ZR72 ^@ Cofactor|||Similarity ^@ Belongs to the 4HPPD family.|||Binds 1 Fe cation per subunit. http://togogenome.org/gene/9597:PAFAH1B1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A5C1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat LIS1/nudF family.|||Can self-associate. Interacts with DCX, dynein, dynactin, IQGAP1, KATNB1, NDE1, NDEL1, NUDC and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling. Component of cytosolic PAF-AH IB, which is composed of PAFAH1B1 (alpha), PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits. Trimer formation is not essential for the catalytic activity of the enzyme which is contributed solely by the PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits.|||Dimerization mediated by the LisH domain may be required to activate dynein.|||Nucleus membrane|||Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position.|||centrosome|||cytoskeleton|||spindle http://togogenome.org/gene/9597:SLC22A4 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4N8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Basal cell membrane|||Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.|||Cell membrane|||Interacts with PDZK1. http://togogenome.org/gene/9597:EPHA3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AMJ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:OTX1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZS9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:BIRC2 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7Y7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IAP family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:RARRES2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CGZ5 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9597:TDRD3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZI96 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Nucleus|||Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1. http://togogenome.org/gene/9597:HMGCL ^@ http://purl.uniprot.org/uniprot/A0A2R9B522 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HMG-CoA lyase family.|||Homodimer; disulfide-linked. Can also form homotetramers.|||Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. http://togogenome.org/gene/9597:XPA ^@ http://purl.uniprot.org/uniprot/A0A2R9C0L1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPA family.|||Nucleus http://togogenome.org/gene/9597:LIPM ^@ http://purl.uniprot.org/uniprot/A0A2R9CBQ7 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9597:LOC100974683 ^@ http://purl.uniprot.org/uniprot/A0A2R9CBJ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.|||Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity.|||Membrane http://togogenome.org/gene/9597:SGCD ^@ http://purl.uniprot.org/uniprot/A0A2R8ZV78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/9597:COQ9 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFF3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COQ9 family.|||Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.|||Mitochondrion http://togogenome.org/gene/9597:CMBL ^@ http://purl.uniprot.org/uniprot/A0A2R9AQR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dienelactone hydrolase family.|||cytosol http://togogenome.org/gene/9597:GNPDA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BM46 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/9597:RGN ^@ http://purl.uniprot.org/uniprot/A0A2R9B6Z4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMP-30/CGR1 family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9597:BCL9 ^@ http://purl.uniprot.org/uniprot/A0A2R9A031 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BCL9 family.|||Nucleus http://togogenome.org/gene/9597:ADAM9 ^@ http://purl.uniprot.org/uniprot/A0A2R9AIT1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:MX1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZN7|||http://purl.uniprot.org/uniprot/K4JEZ2 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/9597:GPR108 ^@ http://purl.uniprot.org/uniprot/A0A2R9AAP6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:CHRNB4 ^@ http://purl.uniprot.org/uniprot/A0A2R9A6Q4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9597:SNRPC ^@ http://purl.uniprot.org/uniprot/A0A2R9CKX7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the U1 small nuclear ribonucleoprotein C family.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Nucleus|||U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. http://togogenome.org/gene/9597:GOT1L1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BBX8 ^@ Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer. http://togogenome.org/gene/9597:MUS81 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZM69 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XPF family.|||Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).|||Interacts with EME1.|||Nucleus http://togogenome.org/gene/9597:LCN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BEH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/9597:RBBP8 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COM1/SAE2/CtIP family.|||Nucleus http://togogenome.org/gene/9597:DUSP6 ^@ http://purl.uniprot.org/uniprot/A0A2R9A2G0 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9597:SNRPA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ASR3 ^@ Similarity ^@ Belongs to the U2 small nuclear ribonucleoprotein A family. http://togogenome.org/gene/9597:OST4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:VPS37C ^@ http://purl.uniprot.org/uniprot/A0A2R9AQ43 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9597:EIF3L ^@ http://purl.uniprot.org/uniprot/A0A2R9BF51 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit L family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RRN3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm http://togogenome.org/gene/9597:FUT9 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6C2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9597:C1RL ^@ http://purl.uniprot.org/uniprot/A0A2R9BEQ0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:LMOD3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZ59 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9597:OCIAD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CRP9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OCIAD1 family.|||Endosome|||Interacts with STAT3.|||Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.|||The OCIA domain is necessary and sufficient for endosomal localization. http://togogenome.org/gene/9597:BYSL ^@ http://purl.uniprot.org/uniprot/A0A2R9A313 ^@ Similarity ^@ Belongs to the bystin family. http://togogenome.org/gene/9597:SKAP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AI38 ^@ Similarity ^@ Belongs to the SKAP family. http://togogenome.org/gene/9597:MRPL3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZF57|||http://purl.uniprot.org/uniprot/A0A2R8ZLM9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/9597:NUDT7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BVP5 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. PCD1 subfamily. http://togogenome.org/gene/9597:CIBAR2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A3D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CIBAR family.|||centriole|||cilium basal body http://togogenome.org/gene/9597:LOC100969159 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHP5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9597:LOC100991359 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGV8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:PDCL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BN33 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9597:CAVIN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B0V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/9597:ARMT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABL2 ^@ Domain|||Function|||Similarity ^@ Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.|||Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.|||Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine. http://togogenome.org/gene/9597:RIN3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C3W0 ^@ Similarity ^@ Belongs to the RIN (Ras interaction/interference) family. http://togogenome.org/gene/9597:CFAP45 ^@ http://purl.uniprot.org/uniprot/A0A2R9B7G7 ^@ Similarity ^@ Belongs to the CFAP45 family. http://togogenome.org/gene/9597:GHITM ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9597:HEATR5A ^@ http://purl.uniprot.org/uniprot/A0A2R9B3B7 ^@ Similarity ^@ Belongs to the HEATR5 family. http://togogenome.org/gene/9597:ACTRT3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BMZ8 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9597:EIF4G3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BQL1 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4G family. http://togogenome.org/gene/9597:LOC100996179 ^@ http://purl.uniprot.org/uniprot/A0A2R9A046 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin Y subfamily. http://togogenome.org/gene/9597:F3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQY7|||http://purl.uniprot.org/uniprot/A0A2R9AXJ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tissue factor family.|||Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.|||Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.|||Membrane http://togogenome.org/gene/9597:GSC ^@ http://purl.uniprot.org/uniprot/A1YG57 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus|||Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity). Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals (By similarity). http://togogenome.org/gene/9597:FLOT2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJ25 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily.|||Cell membrane|||Endosome|||Heterooligomeric complex.|||Membrane|||caveola http://togogenome.org/gene/9597:KRTCAP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A4P3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KRTCAP2 family.|||Membrane http://togogenome.org/gene/9597:USP44 ^@ http://purl.uniprot.org/uniprot/A0A2R9AI97 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9597:ATOSB ^@ http://purl.uniprot.org/uniprot/A0A2R9AZQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATOS family.|||Nucleus http://togogenome.org/gene/9597:MTMR10 ^@ http://purl.uniprot.org/uniprot/A0A2R9A333 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9597:GPR137 ^@ http://purl.uniprot.org/uniprot/A0A2R9BV34 ^@ Subcellular Location Annotation ^@ Lysosome membrane|||Membrane http://togogenome.org/gene/9597:GSDMC ^@ http://purl.uniprot.org/uniprot/A0A2R9BQV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gasdermin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:SLC39A5 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDT9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:BCKDHA ^@ http://purl.uniprot.org/uniprot/A0A2R9BA51 ^@ Function|||Similarity ^@ Belongs to the BCKDHA family.|||Together with BCKDHB forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction. http://togogenome.org/gene/9597:CUL9 ^@ http://purl.uniprot.org/uniprot/A0A2R9BA71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cullin family.|||Cytoplasm http://togogenome.org/gene/9597:PADI3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CL57 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein arginine deiminase family.|||Catalyzes the deimination of arginine residues of proteins.|||Cytoplasm http://togogenome.org/gene/9597:ZNF394 ^@ http://purl.uniprot.org/uniprot/A0A2R9BCM5|||http://purl.uniprot.org/uniprot/A1YG48 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9597:MRAP ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7E5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRAP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:LOC100988315 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZWF1 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9597:LOC100990186 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZF08 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCRH/QCR6 family.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:SLC24A4 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5V7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/9597:UBE2C ^@ http://purl.uniprot.org/uniprot/A0A2R9AJ19 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9597:MRPL24 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZQ1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/9597:NTAQ1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CD66 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NTAQ1 family.|||Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.|||Monomer. http://togogenome.org/gene/9597:MRPS15 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVI4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/9597:TGIF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B1M5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:CD247 ^@ http://purl.uniprot.org/uniprot/A0A2R9CQ55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD3Z/FCER1G family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:MRPL35 ^@ http://purl.uniprot.org/uniprot/A0A2R9CE68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bL35 family.|||Mitochondrion http://togogenome.org/gene/9597:PAEP ^@ http://purl.uniprot.org/uniprot/A0A2R9AU61 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9597:LOC100972384 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9M6 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9597:LOC100980652 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:ACADVL ^@ http://purl.uniprot.org/uniprot/A0A2R9BXB4|||http://purl.uniprot.org/uniprot/A0A2R9C0N0 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9597:ADGRE1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AYD8 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:MED18 ^@ http://purl.uniprot.org/uniprot/A0A2R9AV56 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 18 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9597:TMEM168 ^@ http://purl.uniprot.org/uniprot/A0A2R9CB71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM168 family.|||Membrane|||Nucleus membrane http://togogenome.org/gene/9597:CHMP2A ^@ http://purl.uniprot.org/uniprot/A0A2R9C0C6 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9597:USP45 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZS7 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9597:C9 ^@ http://purl.uniprot.org/uniprot/A0A2R9BNI9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Secreted http://togogenome.org/gene/9597:AP4M1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CGT6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos. The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal.|||Early endosome|||trans-Golgi network membrane http://togogenome.org/gene/9597:TIMELESS ^@ http://purl.uniprot.org/uniprot/A0A2R9BBH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the timeless family.|||Nucleus http://togogenome.org/gene/9597:LOC100972166 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.|||Nucleus http://togogenome.org/gene/9597:DERL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CK79 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Membrane http://togogenome.org/gene/9597:LZTS2 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7K6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LZTS2 family.|||Cytoplasm|||Interacts with KATNB1. Also interacts with CTNNB1, gamma-tubulin and KIF23.|||Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.|||centrosome http://togogenome.org/gene/9597:SSTR3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZR62 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9597:GPR4 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9Z0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:CCR3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:MRPL14 ^@ http://purl.uniprot.org/uniprot/A0A2R9BD85 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL14 family. http://togogenome.org/gene/9597:TSC22D3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BW34|||http://purl.uniprot.org/uniprot/A0A2R9C5T0 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/9597:SPTLC3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BLL9 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9597:HIF3A ^@ http://purl.uniprot.org/uniprot/A0A2R9CMU0 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/9597:PPM1A ^@ http://purl.uniprot.org/uniprot/A0A2R9BCU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PP2C family.|||Membrane|||cytosol http://togogenome.org/gene/9597:SLC7A10 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9J3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:NEU1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BHA9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/9597:ABI3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZV64 ^@ Similarity ^@ Belongs to the ABI family. http://togogenome.org/gene/9597:MCUB ^@ http://purl.uniprot.org/uniprot/A0A2R9ACB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCU (TC 1.A.77) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9597:PIGU ^@ http://purl.uniprot.org/uniprot/A0A2R9BEA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGU family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:MCEE ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPA7 ^@ Similarity ^@ Belongs to the methylmalonyl-CoA epimerase family. http://togogenome.org/gene/9597:NME3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A983 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9597:DOLK ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFN2 ^@ Similarity ^@ Belongs to the polyprenol kinase family. http://togogenome.org/gene/9597:SSBP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AHG7|||http://purl.uniprot.org/uniprot/A0A2R9AIM6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:WASHC5 ^@ http://purl.uniprot.org/uniprot/A0A2R9BF54 ^@ Similarity ^@ Belongs to the strumpellin family. http://togogenome.org/gene/9597:FAIM2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CH37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9597:HHAT ^@ http://purl.uniprot.org/uniprot/A0A2R9CD92 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:TADA2B ^@ http://purl.uniprot.org/uniprot/A0A2R9B1M9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:TEFM ^@ http://purl.uniprot.org/uniprot/A0A2R9BX78 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TEFM family.|||Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery.|||mitochondrion nucleoid http://togogenome.org/gene/9597:LOC100993710 ^@ http://purl.uniprot.org/uniprot/A0A2R9CCU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OXA1/ALB3/YidC family.|||Membrane http://togogenome.org/gene/9597:GPR50 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:PLD4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJD4 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/9597:LARS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BKK9 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9597:IRX1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BLD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/IRO homeobox family.|||Nucleus http://togogenome.org/gene/9597:LOC100995418 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBR4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:DRAM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CSQ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:SEMA3A ^@ http://purl.uniprot.org/uniprot/A0A2R9BBJ2 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:TP53INP2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCD2 ^@ Subcellular Location Annotation ^@ PML body|||autophagosome|||cytosol http://togogenome.org/gene/9597:MAGOH ^@ http://purl.uniprot.org/uniprot/A0A2R9A9W9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mago nashi family.|||Nucleus http://togogenome.org/gene/9597:ZC3H12C ^@ http://purl.uniprot.org/uniprot/A0A2R9C9A0 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/9597:GDA ^@ http://purl.uniprot.org/uniprot/A0A2R9BNQ9|||http://purl.uniprot.org/uniprot/A0A2R9BPF8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.|||Binds 1 zinc ion per subunit.|||Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. http://togogenome.org/gene/9597:CCNO ^@ http://purl.uniprot.org/uniprot/A0A2R8ZXY8 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9597:CFAP36 ^@ http://purl.uniprot.org/uniprot/A0A2R9BY09 ^@ Similarity ^@ Belongs to the CFAP36 family. http://togogenome.org/gene/9597:SMPD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AIC5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acid sphingomyelinase family.|||Binds 2 Zn(2+) ions per subunit.|||Secreted http://togogenome.org/gene/9597:ATP5MK ^@ http://purl.uniprot.org/uniprot/A0A2R9AGT8 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion membrane http://togogenome.org/gene/9597:DPF3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BH70 ^@ Similarity ^@ Belongs to the requiem/DPF family. http://togogenome.org/gene/9597:BAP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A4W5 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/9597:NLN ^@ http://purl.uniprot.org/uniprot/A0A2R9CP99 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/9597:TOP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CGT5 ^@ Function|||Similarity ^@ Belongs to the type IB topoisomerase family.|||Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/9597:WFIKKN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A6V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WFIKKN family.|||Secreted http://togogenome.org/gene/9597:RITA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A207 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RITA family.|||Cytoplasm|||Interacts with RBPJ/RBPSUH.|||Nucleus|||Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis. http://togogenome.org/gene/9597:GABRA5 ^@ http://purl.uniprot.org/uniprot/A0A2R9BFW8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9597:KIFBP ^@ http://purl.uniprot.org/uniprot/A0A2R9BSH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KIF-binding protein family.|||cytoskeleton http://togogenome.org/gene/9597:HMGCS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ASK2 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family.|||Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. http://togogenome.org/gene/9597:GALNT7 ^@ http://purl.uniprot.org/uniprot/A0A2R9B408 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:ABRACL ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQX7 ^@ Similarity ^@ Belongs to the costars family. http://togogenome.org/gene/9597:JRK ^@ http://purl.uniprot.org/uniprot/A0A2R9BMH4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:LHX1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5I6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:TRMT2A ^@ http://purl.uniprot.org/uniprot/A0A2R9CKD7 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:BIRC3 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IAP family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:BORCS5 ^@ http://purl.uniprot.org/uniprot/A0A2R9AND2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS5 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9597:CD8B ^@ http://purl.uniprot.org/uniprot/A0A2R9C6U7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:ITGA4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BC59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9597:FAM8A1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZU30 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:GAB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTS6|||http://purl.uniprot.org/uniprot/A0A2R9C3B3 ^@ Similarity ^@ Belongs to the GAB family. http://togogenome.org/gene/9597:ABL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BA11|||http://purl.uniprot.org/uniprot/A0A2R9BBG8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9597:CHGA ^@ http://purl.uniprot.org/uniprot/A0A2R8ZES5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromogranin/secretogranin protein family.|||Secreted http://togogenome.org/gene/9597:NAF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B4B3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAF1 family.|||Nucleus http://togogenome.org/gene/9597:MTERF3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A906 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/9597:DPRX ^@ http://purl.uniprot.org/uniprot/A0A2R9CKC3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:KCNH1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDK7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:TMEM38A ^@ http://purl.uniprot.org/uniprot/A0A2R8Z8K2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM38 family.|||Membrane|||Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. http://togogenome.org/gene/9597:RSAD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BU92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.|||May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen-III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Mitochondrion http://togogenome.org/gene/9597:COQ2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BPT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family.|||Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis. Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl donor (such as all-trans-decaprenyl diphosphate or trans-nonaprenyl diphosphate). The length of the polyprenyl side chain varies depending on the species, in humans, the side chain is comprised of 10 isoprenyls producing CoQ10 (also known as ubiquinone), whereas rodents predominantly generate CoQ9. However, this specificity is not complete, human tissues have low amounts of CoQ9 and rodent organs contain some CoQ10. CoQs are vital molecules that transport electrons from mitochondrial respiratory chain complexes. CoQs also function as cofactors for uncoupling protein and play a role as regulators of the extracellularly-induced ceramide-dependent apoptotic pathway. Regulates mitochondrial permeability transition pore (mPTP) opening and ROS production (pivotal events in cell death) in a tissue specific manner.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:RPL7L1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYZ6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/9597:TSPOAP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJ37|||http://purl.uniprot.org/uniprot/A0A2R8ZQC2 ^@ Similarity ^@ Belongs to the RIMBP family. http://togogenome.org/gene/9597:GPX8 ^@ http://purl.uniprot.org/uniprot/A0A2R9B736 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/9597:LETMD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BPZ9|||http://purl.uniprot.org/uniprot/A0A2R9BZ08 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9597:SYBU ^@ http://purl.uniprot.org/uniprot/A0A2R9AQN4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:TMED3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BX70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9597:PLOD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUL7|||http://purl.uniprot.org/uniprot/A0A2R9BV87 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9597:ECHDC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BHI4 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9597:LAMP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A4I2|||http://purl.uniprot.org/uniprot/A0A2R9A4I8|||http://purl.uniprot.org/uniprot/A0A2R9A7Z7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9597:ERBIN ^@ http://purl.uniprot.org/uniprot/A0A2R9B923|||http://purl.uniprot.org/uniprot/A0A2R9B926|||http://purl.uniprot.org/uniprot/A0A2R9BAH0|||http://purl.uniprot.org/uniprot/A0A2R9BCS8 ^@ Similarity ^@ Belongs to the LAP (LRR and PDZ) protein family. http://togogenome.org/gene/9597:DHCR7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Membrane http://togogenome.org/gene/9597:SLC26A2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BLZ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane|||Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development. Mediates electroneutral anion exchange of sulfate ions for oxalate ions, sulfate and oxalate ions for chloride and/or hydroxyl ions and chloride ions for bromide, iodide and nitrate ions. The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange. Essential for chondrocyte proliferation, differentiation and cell size expansion. http://togogenome.org/gene/9597:PLCB1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKZ8|||http://purl.uniprot.org/uniprot/A0A2R8ZNS9 ^@ Cofactor|||Function ^@ Binds 1 Ca(2+) ion per subunit.|||The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. http://togogenome.org/gene/9597:NXPH4 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7W6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/9597:MEOX1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BLY6|||http://purl.uniprot.org/uniprot/A1YGA4 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome.|||Nucleus http://togogenome.org/gene/9597:TMEM107 ^@ http://purl.uniprot.org/uniprot/A0A2R9CCI2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:RPL3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BQK0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/9597:RPS3A ^@ http://purl.uniprot.org/uniprot/A0A2R9CMC4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS1 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.|||Cytoplasm|||May play a role during erythropoiesis through regulation of transcription factor DDIT3.|||Nucleus|||nucleolus http://togogenome.org/gene/9597:BMP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJF6|||http://purl.uniprot.org/uniprot/A0A2R8ZPX7 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:SERPINA3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BT16 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9597:GOLGA5 ^@ http://purl.uniprot.org/uniprot/A0A2R9BM95 ^@ Function|||Subcellular Location Annotation ^@ Golgi apparatus membrane|||Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. http://togogenome.org/gene/9597:WWOX ^@ http://purl.uniprot.org/uniprot/A0A2R9BKA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm|||Golgi apparatus|||Lysosome|||Mitochondrion http://togogenome.org/gene/9597:KRR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFW2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KRR1 family.|||Component of the ribosomal small subunit (SSU) processome.|||Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.|||nucleolus http://togogenome.org/gene/9597:CFAP144 ^@ http://purl.uniprot.org/uniprot/A0A2R9CEL2 ^@ Similarity ^@ Belongs to the CFAP144 family. http://togogenome.org/gene/9597:ENKD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B3C0 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9597:KDM4E ^@ http://purl.uniprot.org/uniprot/A0A2R8ZL50 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:GPR37 ^@ http://purl.uniprot.org/uniprot/A0A2R9AID0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:KAT7 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4N7|||http://purl.uniprot.org/uniprot/A0A2R9CER6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/9597:AGO3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AKL6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argonaute family. Ago subfamily.|||Interacts with EIF4B, IMP8, PRMT5 and TNRC6B. Interacts with APOBEC3F, APOBEC3G and APOBEC3H.|||P-body|||Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. http://togogenome.org/gene/9597:DGUOK ^@ http://purl.uniprot.org/uniprot/A0A2R9BLX3|||http://purl.uniprot.org/uniprot/A0A2R9BMT5 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/9597:PHETA2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCD7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sesquipedalian family.|||Early endosome|||Forms homodimers and heterodimers with PHETA. Interacts with OCRL and INPP5B.|||Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.|||Recycling endosome|||clathrin-coated vesicle|||trans-Golgi network http://togogenome.org/gene/9597:ACKR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AUQ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.|||Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.|||Early endosome|||Membrane|||Recycling endosome http://togogenome.org/gene/9597:PHLDA3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZI68 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:NUBP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A296 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.|||Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.|||Cell projection|||Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.|||Cytoplasm|||Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1. http://togogenome.org/gene/9597:VGLL4 ^@ http://purl.uniprot.org/uniprot/A0A2R9B6G4|||http://purl.uniprot.org/uniprot/A0A2R9B6I2|||http://purl.uniprot.org/uniprot/A0A2R9BDL1 ^@ Function|||Similarity ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs. http://togogenome.org/gene/9597:MGST1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Membrane http://togogenome.org/gene/9597:GTF2A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJ75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 1 family.|||Nucleus http://togogenome.org/gene/9597:PLIN2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBB9|||http://purl.uniprot.org/uniprot/A0A2R8ZI15 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/9597:PRSS16 ^@ http://purl.uniprot.org/uniprot/A0A2R9A5V9 ^@ Similarity ^@ Belongs to the peptidase S28 family. http://togogenome.org/gene/9597:MOCS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B0D2 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MoaE family. MOCS2B subfamily.|||Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.|||Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.|||This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame.|||cytosol http://togogenome.org/gene/9597:SLC52A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BPA1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the riboflavin transporter family.|||Cell membrane|||Membrane|||Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. http://togogenome.org/gene/9597:GLRB ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane http://togogenome.org/gene/9597:CRHR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CMC7|||http://purl.uniprot.org/uniprot/A0A2R9CME9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.|||Membrane http://togogenome.org/gene/9597:LOC100983088 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUK3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/9597:VAT1L ^@ http://purl.uniprot.org/uniprot/A0A2R9A0E9 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/9597:PHKA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BBG6|||http://purl.uniprot.org/uniprot/A0A2R9BFB2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.|||Belongs to the phosphorylase b kinase regulatory chain family.|||Cell membrane|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.|||Membrane|||Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. http://togogenome.org/gene/9597:SLC25A47 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJ61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9597:FAM13B ^@ http://purl.uniprot.org/uniprot/A0A2R9ANS0|||http://purl.uniprot.org/uniprot/A0A2R9AT97 ^@ Similarity ^@ Belongs to the FAM13 family. http://togogenome.org/gene/9597:ZNF674 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSH9 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:APAF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AIY1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Monomer. Oligomerizes upon binding of cytochrome c and dATP.|||Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. http://togogenome.org/gene/9597:ADA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSU9|||http://purl.uniprot.org/uniprot/A0A2R9BSV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.|||Secreted http://togogenome.org/gene/9597:RPL5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZY92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL18 family.|||Cytoplasm http://togogenome.org/gene/9597:CYP2U1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CKC9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9597:DPY30 ^@ http://purl.uniprot.org/uniprot/A0A2R9BZ79 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/9597:ATG16L1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BEF8|||http://purl.uniprot.org/uniprot/A0A2R9BFM6|||http://purl.uniprot.org/uniprot/A0A2R9BMW5 ^@ Similarity ^@ Belongs to the WD repeat ATG16 family. http://togogenome.org/gene/9597:TMEM9B ^@ http://purl.uniprot.org/uniprot/A0A2R9A3N4 ^@ Similarity ^@ Belongs to the TMEM9 family. http://togogenome.org/gene/9597:SLC6A14 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZY55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9597:HSD17B12 ^@ http://purl.uniprot.org/uniprot/A0A2R9C3H2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9597:FIP1L1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FIP1 family.|||Nucleus http://togogenome.org/gene/9597:LOC100967723 ^@ http://purl.uniprot.org/uniprot/A0A2R9BAA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MHC class II family.|||Endosome membrane|||Lysosome membrane http://togogenome.org/gene/9597:EIF4E1B ^@ http://purl.uniprot.org/uniprot/A0A2R9BBA4 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/9597:MICAL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BD02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mical family.|||Cytoplasm http://togogenome.org/gene/9597:ETFDH ^@ http://purl.uniprot.org/uniprot/A0A2R9B258 ^@ Cofactor|||Function ^@ Accepts electrons from ETF and reduces ubiquinone.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/9597:DDA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C6K3 ^@ Similarity ^@ Belongs to the DDA1 family. http://togogenome.org/gene/9597:AHCY ^@ http://purl.uniprot.org/uniprot/A0A2R9BHH3 ^@ Similarity ^@ Belongs to the adenosylhomocysteinase family. http://togogenome.org/gene/9597:PKMYT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BCZ9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:BPNT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDK3 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/9597:TRIT1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPL5 ^@ Function|||Similarity ^@ Belongs to the IPP transferase family.|||Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37. http://togogenome.org/gene/9597:MS4A3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BFU4|||http://purl.uniprot.org/uniprot/A0A2R9BN34 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9597:ALKBH8 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alkB family.|||Cytoplasm http://togogenome.org/gene/9597:RMI1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFQ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RMI1 family.|||Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.|||Nucleus http://togogenome.org/gene/9597:STARD13 ^@ http://purl.uniprot.org/uniprot/A0A2R9BNF4|||http://purl.uniprot.org/uniprot/A0A2R9BNJ2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:NAT1 ^@ http://purl.uniprot.org/uniprot/A0A4P8J1D3 ^@ Similarity ^@ Belongs to the arylamine N-acetyltransferase family. http://togogenome.org/gene/9597:TUBGCP3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBL3|||http://purl.uniprot.org/uniprot/A0A2R8ZID3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.|||centrosome http://togogenome.org/gene/9597:GRK5 ^@ http://purl.uniprot.org/uniprot/A0A2R9A0D5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9597:CD5L ^@ http://purl.uniprot.org/uniprot/A0A2R9CA56 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:SLITRK4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDQ2 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9597:ANXA5 ^@ http://purl.uniprot.org/uniprot/A0A2R9AHE1 ^@ Domain|||Function|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. http://togogenome.org/gene/9597:MIOX ^@ http://purl.uniprot.org/uniprot/A0A2R9BVT3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the myo-inositol oxygenase family.|||Binds 2 iron ions per subunit.|||Cytoplasm http://togogenome.org/gene/9597:LPIN3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C284 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/9597:TRMT112 ^@ http://purl.uniprot.org/uniprot/A0A2R9C609 ^@ Similarity ^@ Belongs to the TRM112 family. http://togogenome.org/gene/9597:TBX22 ^@ http://purl.uniprot.org/uniprot/A0A2R9C3Q1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9597:MARCO ^@ http://purl.uniprot.org/uniprot/A0A2R9BMI0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:TMEM8B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:CACNB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AQ94|||http://purl.uniprot.org/uniprot/A0A2R9AQW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||Membrane|||sarcolemma http://togogenome.org/gene/9597:B9D2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9N0 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/9597:EIF1AX ^@ http://purl.uniprot.org/uniprot/A0A2R9AWQ3 ^@ Function|||Similarity ^@ Belongs to the eIF-1A family.|||Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. http://togogenome.org/gene/9597:MYO1G ^@ http://purl.uniprot.org/uniprot/A0A2R9C381 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9597:CRHBP ^@ http://purl.uniprot.org/uniprot/A0A2R9C566 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CRF-binding protein family.|||Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.|||Secreted http://togogenome.org/gene/9597:CEBPG ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTZ3 ^@ Similarity ^@ Belongs to the bZIP family. C/EBP subfamily. http://togogenome.org/gene/9597:ZNF10 ^@ http://purl.uniprot.org/uniprot/A0A2R9AAE4 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:CDADC1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZP7 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/9597:THBS1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIE8 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:MRPL15 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXT2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/9597:NDUFA1 ^@ http://purl.uniprot.org/uniprot/Q7JGX4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA1 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:ZIC3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A8U8 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/9597:LOC100984360 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZF70 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:ZNF597 ^@ http://purl.uniprot.org/uniprot/A0A2R9AT38 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:EMC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CLQ1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC1 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:SPDEF ^@ http://purl.uniprot.org/uniprot/A0A2R9CCT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9597:GALNT18 ^@ http://purl.uniprot.org/uniprot/A0A2R9C0Y9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:HPX ^@ http://purl.uniprot.org/uniprot/A0A2R9CB08 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the hemopexin family.|||Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.|||Secreted http://togogenome.org/gene/9597:SS18 ^@ http://purl.uniprot.org/uniprot/A0A2R9BHB4|||http://purl.uniprot.org/uniprot/A0A2R9BR14 ^@ Similarity ^@ Belongs to the SS18 family. http://togogenome.org/gene/9597:ZNF398 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUC4 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:LOC100974907 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZG93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:PPME1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BE14 ^@ Function|||Similarity|||Subunit ^@ Belongs to the AB hydrolase superfamily.|||Binds PPP2CA and PPP2CB.|||Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. http://togogenome.org/gene/9597:ABCC8 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZS53 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with KCNJ11.|||Membrane http://togogenome.org/gene/9597:PRDX1 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6R9 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/9597:UBR4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZK63 ^@ Similarity ^@ Belongs to the UBR4 family. http://togogenome.org/gene/9597:DSG1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C939 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.|||Membrane|||desmosome http://togogenome.org/gene/9597:GGACT ^@ http://purl.uniprot.org/uniprot/A0A2R9AWP5 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family.|||Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. http://togogenome.org/gene/9597:CAPZA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B1W8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/9597:NCAPD3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CLG1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the condensin-2 complex.|||Nucleus|||Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. http://togogenome.org/gene/9597:SPEM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CLU4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:NDUFAF4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BNL8 ^@ Similarity|||Subunit ^@ Belongs to the NDUFAF4 family.|||Binds calmodulin. Interacts with NDUFAF3. http://togogenome.org/gene/9597:LOC100992975 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZI20 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:EMC9 ^@ http://purl.uniprot.org/uniprot/A0A2R9BRH6 ^@ Similarity ^@ Belongs to the EMC8/EMC9 family. http://togogenome.org/gene/9597:NPC1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZK38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the patched family.|||Membrane http://togogenome.org/gene/9597:PRR5L ^@ http://purl.uniprot.org/uniprot/A0A2R9CMG1 ^@ Similarity ^@ Belongs to the PROTOR family. http://togogenome.org/gene/9597:BLK ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDG4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9597:VPS26A ^@ http://purl.uniprot.org/uniprot/A0A2R9C7R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS26 family.|||Endosome http://togogenome.org/gene/9597:UBE2H ^@ http://purl.uniprot.org/uniprot/A0A2R9CDK8 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9597:LAMA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AFC7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/9597:SH2B1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BAC4 ^@ Similarity ^@ Belongs to the SH2B adapter family. http://togogenome.org/gene/9597:CILP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BAG9 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9597:LMLN ^@ http://purl.uniprot.org/uniprot/A0A2R9CC25 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M8 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9597:HNRNPDL ^@ http://purl.uniprot.org/uniprot/A0A2R9CQQ7 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9597:DYNC1I1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CKL4|||http://purl.uniprot.org/uniprot/A0A2R9CRF2 ^@ Similarity ^@ Belongs to the dynein intermediate chain family. http://togogenome.org/gene/9597:PHKG1 ^@ http://purl.uniprot.org/uniprot/A0A2R9ASX0 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily.|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin. http://togogenome.org/gene/9597:PKNOX2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CF88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/9597:GSR ^@ http://purl.uniprot.org/uniprot/A0A2R9B7N6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Cytoplasm|||Maintains high levels of reduced glutathione in the cytosol. http://togogenome.org/gene/9597:SLC35A3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C031 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:TMEM199 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZI11 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:IPO8 ^@ http://purl.uniprot.org/uniprot/A0A2R9CAE9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:SH3YL1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFR7|||http://purl.uniprot.org/uniprot/A0A2R8ZG58 ^@ Similarity|||Subunit ^@ Belongs to the SH3YL1 family.|||Interacts with SH3D19. http://togogenome.org/gene/9597:DHODH ^@ http://purl.uniprot.org/uniprot/A0A2R9BWW0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:KPNA6 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHT3 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9597:EMX2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A2P6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:EPS8L2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B3G7 ^@ Similarity ^@ Belongs to the EPS8 family. http://togogenome.org/gene/9597:SLC43A1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFD1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:SNCA ^@ http://purl.uniprot.org/uniprot/P61144 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.|||Belongs to the synuclein family.|||Cytoplasm|||Membrane|||Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (By similarity). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (By similarity). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (By similarity). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (By similarity). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (By similarity). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (By similarity).|||Nucleus|||Phosphorylated, predominantly on serine residues. Phosphorylated on Tyr-125 upon osmotic stress.|||Secreted|||Soluble monomer. Homotetramer. A dynamic intracellular population of tetramers and monomers coexists normally and the tetramer plays an essential role in maintaining homeostasis (By similarity). Interacts with UCHL1 (By similarity). Interacts with phospholipase D and histones. Interacts (via N-terminus) with synphilin-1/SNCAIP; this interaction promotes formation of SNCA inclusions in the cytoplasm. Interacts with CALM1. Interacts with STXBP1; this interaction controls SNCA self-replicating aggregation. Interacts with SNARE components VAMP2 and SNAP25; these interactions allows SNARE complex assembly and integrity (By similarity). Interacts with RPH3A and RAB3A (By similarity). Interacts with SERF1A; this interaction promotes the aggregation of SNCA (By similarity). Interacts with SEPTIN4 (By similarity).|||Synapse|||Ubiquitinated. The predominant conjugate is the diubiquitinated form.|||axon http://togogenome.org/gene/9597:MRPL28 ^@ http://purl.uniprot.org/uniprot/A0A2R9B317 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/9597:ZHX3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZHX family.|||Nucleus http://togogenome.org/gene/9597:SLC17A9 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFI7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:HIF1A ^@ http://purl.uniprot.org/uniprot/A0A2R9A0V2 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus speckle http://togogenome.org/gene/9597:YIF1A ^@ http://purl.uniprot.org/uniprot/A0A2R9C3C9|||http://purl.uniprot.org/uniprot/A0A2R9C6E9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIF1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Has a role in transport between endoplasmic reticulum and Golgi.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:WDR35 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJF8 ^@ Function|||Subcellular Location Annotation ^@ As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking.|||centrosome|||cilium basal body http://togogenome.org/gene/9597:SERPINB7 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1V2 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9597:LIG1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CMP9 ^@ Similarity ^@ Belongs to the ATP-dependent DNA ligase family. http://togogenome.org/gene/9597:PAH ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCI5|||http://purl.uniprot.org/uniprot/A0A2R8ZJB8 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/9597:ANAPC10 ^@ http://purl.uniprot.org/uniprot/A0A2R9B1F2 ^@ Function|||Similarity ^@ Belongs to the APC10 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. http://togogenome.org/gene/9597:GCHFR ^@ http://purl.uniprot.org/uniprot/A0A2R9BAE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GFRP family.|||Membrane|||Nucleus membrane|||cytosol http://togogenome.org/gene/9597:FSHR ^@ http://purl.uniprot.org/uniprot/A0A2R9AR68 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.|||Membrane http://togogenome.org/gene/9597:STEEP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZWA0 ^@ Similarity ^@ Belongs to the STEEP1 family. http://togogenome.org/gene/9597:RAB3D ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZX9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/9597:PGAP3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AYY9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PGAP3 family.|||Golgi apparatus membrane|||Involved in the lipid remodeling steps of GPI-anchor maturation.|||Membrane http://togogenome.org/gene/9597:HTRA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CCL7 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/9597:GLRA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CBB5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane|||dendrite http://togogenome.org/gene/9597:SLC35E3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BVJ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:GADL1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZX33 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9597:ADGRV1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B2B1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:TCEA1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZA45 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family.|||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.|||Nucleus http://togogenome.org/gene/9597:DOK2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BT20 ^@ Similarity ^@ Belongs to the DOK family. Type A subfamily. http://togogenome.org/gene/9597:SCGB1C1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A3G5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the secretoglobin family.|||Secreted http://togogenome.org/gene/9597:PIGV ^@ http://purl.uniprot.org/uniprot/A0A2R9AWR8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGV family.|||Endoplasmic reticulum membrane|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.|||Membrane http://togogenome.org/gene/9597:KCNK7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9597:TBCB ^@ http://purl.uniprot.org/uniprot/A0A2R9CG94 ^@ Similarity ^@ Belongs to the TBCB family. http://togogenome.org/gene/9597:DDX21 ^@ http://purl.uniprot.org/uniprot/A0A2R9BC84 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily. http://togogenome.org/gene/9597:LOC100983218 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCH5 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:IDNK ^@ http://purl.uniprot.org/uniprot/A0A2R8ZXW8 ^@ Similarity ^@ Belongs to the gluconokinase GntK/GntV family. http://togogenome.org/gene/9597:RSPO2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A5T7 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/9597:BTC ^@ http://purl.uniprot.org/uniprot/A0A2R9AUY6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:CENPM ^@ http://purl.uniprot.org/uniprot/A0A2R9BF80|||http://purl.uniprot.org/uniprot/A0A2R9BJ12 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:LLGL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A360|||http://purl.uniprot.org/uniprot/A0A2R9A7D4 ^@ Similarity ^@ Belongs to the WD repeat L(2)GL family. http://togogenome.org/gene/9597:PLAC8 ^@ http://purl.uniprot.org/uniprot/A0A2R9B1N9 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/9597:PIH1D1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BCA5 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/9597:LCN15 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1I4 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9597:DDIT4L ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQW6 ^@ Similarity ^@ Belongs to the DDIT4 family. http://togogenome.org/gene/9597:POMK ^@ http://purl.uniprot.org/uniprot/A0A2R9BAA0 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif. http://togogenome.org/gene/9597:KRI1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C8R9 ^@ Similarity ^@ Belongs to the KRI1 family. http://togogenome.org/gene/9597:STON1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTT3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Stoned B family.|||Cytoplasm|||May be involved in the endocytic machinery. http://togogenome.org/gene/9597:RPE ^@ http://purl.uniprot.org/uniprot/A0A2R9B0Z6 ^@ Cofactor|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/9597:SLC37A4 ^@ http://purl.uniprot.org/uniprot/A0A2R9BE17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Membrane http://togogenome.org/gene/9597:LOC100990756 ^@ http://purl.uniprot.org/uniprot/A0A2R9ALQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9597:NIP7 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZC01 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NIP7 family.|||Interacts with pre-ribosome complex.|||Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.|||nucleolus http://togogenome.org/gene/9597:IP6K1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZG47 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9597:NUF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CF19 ^@ Similarity ^@ Belongs to the NUF2 family. http://togogenome.org/gene/9597:NELFE ^@ http://purl.uniprot.org/uniprot/A0A2R9BWZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM NELF-E family.|||Chromosome|||Nucleus http://togogenome.org/gene/9597:LIM2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C2B7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis. http://togogenome.org/gene/9597:HIGD1C ^@ http://purl.uniprot.org/uniprot/A0A2R9B916 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/9597:LTA ^@ http://purl.uniprot.org/uniprot/A0A2R9BST5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.|||Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. Interacts with TNFRSF14.|||Membrane|||Secreted http://togogenome.org/gene/9597:BCAS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AI83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPF27 family.|||Nucleus http://togogenome.org/gene/9597:PLBD2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZXD7 ^@ Function|||Similarity ^@ Belongs to the phospholipase B-like family.|||Putative phospholipase. http://togogenome.org/gene/9597:CCL8 ^@ http://purl.uniprot.org/uniprot/A0A2R9BZP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9597:PGM2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C685 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/9597:ZCCHC4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AF87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZCCHC4 family.|||Cytoplasm|||nucleolus http://togogenome.org/gene/9597:JOSD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AI59 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:GALNT14 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9597:LOC100975679 ^@ http://purl.uniprot.org/uniprot/A0A2R9AMC4 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/9597:SFXN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AMT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9597:ASZ1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C604 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.|||Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation. http://togogenome.org/gene/9597:SEC61G ^@ http://purl.uniprot.org/uniprot/A0A2R9B504 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecE/SEC61-gamma family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:PIGP ^@ http://purl.uniprot.org/uniprot/A0A2R9B4R2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGP family.|||Membrane|||Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. http://togogenome.org/gene/9597:PTGES3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZD55|||http://purl.uniprot.org/uniprot/A0A2R8ZD59|||http://purl.uniprot.org/uniprot/A0A2R8ZJX3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the p23/wos2 family.|||Cytoplasm|||Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation.|||Forms a complex with HSP70, HSP90 and other chaperones. http://togogenome.org/gene/9597:TMEM38B ^@ http://purl.uniprot.org/uniprot/A0A2R9AXJ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM38 family.|||Membrane|||Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. http://togogenome.org/gene/9597:CCNT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BFQ3|||http://purl.uniprot.org/uniprot/A0A2R9BFR5 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9597:UTP14A ^@ http://purl.uniprot.org/uniprot/A0A2R9CCD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP14 family.|||nucleolus http://togogenome.org/gene/9597:CENPS ^@ http://purl.uniprot.org/uniprot/A0A2R9BKQ0 ^@ Similarity ^@ Belongs to the TAF9 family. CENP-S/MHF1 subfamily. http://togogenome.org/gene/9597:PGM3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AV39 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation. http://togogenome.org/gene/9597:POLR1H ^@ http://purl.uniprot.org/uniprot/A0A2R9AYL4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.|||nucleolus http://togogenome.org/gene/9597:IZUMO3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CKN6 ^@ Similarity ^@ Belongs to the Izumo family. http://togogenome.org/gene/9597:FIGN ^@ http://purl.uniprot.org/uniprot/A0A2R9ARQ6 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9597:APOM ^@ http://purl.uniprot.org/uniprot/A0A2R9AP33 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family. Highly divergent.|||Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.|||Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.|||Secreted http://togogenome.org/gene/9597:SLC35F6 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNR5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SLC35F solute transporter family.|||Interacts with SLC25A5.|||May play a role as a nucleotide-sugar transporter.|||Membrane|||Mitochondrion http://togogenome.org/gene/9597:AZIN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AAQ7 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/9597:PRPS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDT0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family.|||Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.|||Homodimer. The active form is probably a hexamer composed of 3 homodimers. http://togogenome.org/gene/9597:STK17B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLI1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:ART1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A8F9 ^@ Similarity ^@ Belongs to the Arg-specific ADP-ribosyltransferase family. http://togogenome.org/gene/9597:ENTPD3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C6V1 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9597:ENOPH1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B7Z9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.|||Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Monomer.|||Nucleus http://togogenome.org/gene/9597:TRMT1L ^@ http://purl.uniprot.org/uniprot/A0A2R9A3L0 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.|||May play a role in motor coordination and exploratory behavior. http://togogenome.org/gene/9597:CPXM2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BN00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||Secreted http://togogenome.org/gene/9597:ZSCAN16 ^@ http://purl.uniprot.org/uniprot/A0A2R9BE49 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:NSA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CFY4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.|||Component of the pre-66S ribosomal particle.|||Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.|||nucleolus http://togogenome.org/gene/9597:AMIGO2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. AMIGO family.|||Membrane http://togogenome.org/gene/9597:KPNA3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZF8 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9597:ZNF610 ^@ http://purl.uniprot.org/uniprot/A0A2R9B6V9 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:CCNA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDL2|||http://purl.uniprot.org/uniprot/A0A2R9CNX9 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin AB subfamily. http://togogenome.org/gene/9597:POLR3B ^@ http://purl.uniprot.org/uniprot/A0A2R9B527 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/9597:MIP ^@ http://purl.uniprot.org/uniprot/A0A2R9CLF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9597:NAXD ^@ http://purl.uniprot.org/uniprot/A0A2R9AZR9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NnrD/CARKD family.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Mitochondrion http://togogenome.org/gene/9597:NUTF2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CNS8 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/9597:GGCX ^@ http://purl.uniprot.org/uniprot/A0A2R9AHA6|||http://purl.uniprot.org/uniprot/A0A2R9AL65 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:KRBOX1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BRL7 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:UGT2A3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AUB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9597:PICK1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A4R5 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.|||cytoskeleton|||perinuclear region|||synaptosome http://togogenome.org/gene/9597:KIF18B ^@ http://purl.uniprot.org/uniprot/A0A2R9BPR4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9597:ALKBH5 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABJ6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alkB family.|||Monomer.|||Nucleus speckle http://togogenome.org/gene/9597:PLPP3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CLP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9597:PSMA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BBY3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9597:CD44 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJK6|||http://purl.uniprot.org/uniprot/A0A2R9CJL8|||http://purl.uniprot.org/uniprot/A0A2R9CSB7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||microvillus http://togogenome.org/gene/9597:ZNF277 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACZ1 ^@ Similarity ^@ Belongs to the ZNF277 family. http://togogenome.org/gene/9597:TATDN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A5S1 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. http://togogenome.org/gene/9597:SIX1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4R6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:ALDH1A2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B140 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9597:CXCL14 ^@ http://purl.uniprot.org/uniprot/A0A2R9BWC6 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9597:PSMD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BE76 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S2 family.|||Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. http://togogenome.org/gene/9597:FARSB ^@ http://purl.uniprot.org/uniprot/A0A2R9C2A7 ^@ Similarity ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily. http://togogenome.org/gene/9597:LOC100978919 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJG0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:OPRL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5I3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasmic vesicle|||G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.|||Membrane|||Vesicle http://togogenome.org/gene/9597:LOC103784759 ^@ http://purl.uniprot.org/uniprot/A0A2R9BCB9 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:TLCD3B ^@ http://purl.uniprot.org/uniprot/A0A2R9CJL1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:ADCY10 ^@ http://purl.uniprot.org/uniprot/A0A2R9AU90 ^@ Function|||Similarity ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels. Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. Involved in ciliary beat regulation. http://togogenome.org/gene/9597:TMEM267 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z687 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:LIN7A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZX44 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the lin-7 family.|||Cell membrane|||Lateral cell membrane|||Membrane|||Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.|||Postsynaptic density membrane|||tight junction http://togogenome.org/gene/9597:MED17 ^@ http://purl.uniprot.org/uniprot/A0A2R9BM32 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 17 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9597:SETD3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BBP7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.|||Cytoplasm|||Interacts with MYOD1. http://togogenome.org/gene/9597:PYGM ^@ http://purl.uniprot.org/uniprot/A0A2R9A768 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/9597:URM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AE82|||http://purl.uniprot.org/uniprot/A0A2R9AJ31 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.|||Belongs to the URM1 family.|||C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.|||Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.|||Cytoplasm http://togogenome.org/gene/9597:KRT39 ^@ http://purl.uniprot.org/uniprot/A0A2R9CHL9 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9597:IRF3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B6Q3|||http://purl.uniprot.org/uniprot/A0A2R9B856|||http://purl.uniprot.org/uniprot/A0A2R9BDU3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:IL12B ^@ http://purl.uniprot.org/uniprot/A0A2R9BID0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.|||Belongs to the IL-12B family.|||Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.|||Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12.|||Secreted http://togogenome.org/gene/9597:THOC6 ^@ http://purl.uniprot.org/uniprot/A0A2R9ASV0 ^@ Similarity ^@ Belongs to the WD repeat THOC6 family. http://togogenome.org/gene/9597:MVB12A ^@ http://purl.uniprot.org/uniprot/A0A2R9BDD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MVB12 family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9597:ATP7A ^@ http://purl.uniprot.org/uniprot/A0A2R9CJU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9597:EEIG1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7Q0 ^@ Similarity ^@ Belongs to the EEIG family. http://togogenome.org/gene/9597:CD4 ^@ http://purl.uniprot.org/uniprot/A0A2R9B4G7 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9597:CDS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BKA1|||http://purl.uniprot.org/uniprot/A0A2R9BNV0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Membrane http://togogenome.org/gene/9597:FAM219B ^@ http://purl.uniprot.org/uniprot/A0A2R9CM39 ^@ Similarity ^@ Belongs to the FAM219 family. http://togogenome.org/gene/9597:LOC100988669 ^@ http://purl.uniprot.org/uniprot/A0A2R9AS01 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9597:ULK3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZC8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:C11H11orf87 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6R7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:GDPD5 ^@ http://purl.uniprot.org/uniprot/A0A2R9CC92 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9597:TRMO ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDR4 ^@ Similarity ^@ Belongs to the tRNA methyltransferase O family. http://togogenome.org/gene/9597:E2F7 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7E6|||http://purl.uniprot.org/uniprot/A0A2R8ZDR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9597:DHRS7 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPB8 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9597:KCNK5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9597:KCNK18 ^@ http://purl.uniprot.org/uniprot/A0A2R9CE63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9597:SLC33A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A788 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:GYS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CAG3 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase 3 family.|||Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. http://togogenome.org/gene/9597:PDE6D ^@ http://purl.uniprot.org/uniprot/A0A2R9ACJ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PDE6D/unc-119 family.|||Cytoplasmic vesicle membrane|||Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains and two inhibitory chains; has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane.|||Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.|||cilium basal body|||cytosol http://togogenome.org/gene/9597:ACAA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTH0 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/9597:CCSER1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BKW0 ^@ Similarity ^@ Belongs to the CCSER family. http://togogenome.org/gene/9597:SLC37A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXV6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.|||Membrane http://togogenome.org/gene/9597:NDUFS6 ^@ http://purl.uniprot.org/uniprot/A0A2R9BQ40 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS6 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:IL18 ^@ http://purl.uniprot.org/uniprot/A0A2R9A3C8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Cytoplasm|||Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.|||Secreted http://togogenome.org/gene/9597:PRM2 ^@ http://purl.uniprot.org/uniprot/P35299 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the protamine P2 family.|||Chromosome|||Interacts with TDRP.|||Nucleus|||Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.|||Proteolytic processing into mature chains is required for histone eviction during spermatogenesis. Transition proteins (TNP1 and TNP2) are required for processing.|||Testis. http://togogenome.org/gene/9597:FBLN7 ^@ http://purl.uniprot.org/uniprot/A0A2R9AMM3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:IPO9 ^@ http://purl.uniprot.org/uniprot/A0A2R9BK65 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:TBX18 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1N2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9597:C3AR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLW9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Interacts with VGF-derived peptide TLQP-21.|||Membrane|||Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. http://togogenome.org/gene/9597:PSMA3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B530 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9597:MMD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CCE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9597:ARRDC2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AGZ1 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9597:PSMB4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AAM6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1B family.|||Cytoplasm|||Non-catalytic component of the proteasome.|||Nucleus http://togogenome.org/gene/9597:LOC100989931 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z949 ^@ Function|||Similarity ^@ Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis. http://togogenome.org/gene/9597:PARP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5K0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARTD/PARP family.|||Chromosome|||Interacts (when auto-poly-ADP-ribosylated) with AIFM1.|||Nucleus|||Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair.|||This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. http://togogenome.org/gene/9597:DNASE1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B4D1 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/9597:TUFM ^@ http://purl.uniprot.org/uniprot/A0A2R9B376 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/9597:SERF2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZY25 ^@ Similarity ^@ Belongs to the SERF family. http://togogenome.org/gene/9597:FOXR2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLN4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:PPBP ^@ http://purl.uniprot.org/uniprot/A0A2R9CA87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9597:PRPS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B019 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family.|||Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.|||Homodimer. The active form is probably a hexamer composed of 3 homodimers. http://togogenome.org/gene/9597:RAB3IP ^@ http://purl.uniprot.org/uniprot/A0A2R9BQJ4 ^@ Similarity ^@ Belongs to the SEC2 family. http://togogenome.org/gene/9597:PRORP ^@ http://purl.uniprot.org/uniprot/A0A2R9C336|||http://purl.uniprot.org/uniprot/A0A2R9C5M1 ^@ Similarity ^@ Belongs to the PPR family. P subfamily. http://togogenome.org/gene/9597:DEGS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AT49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:DBT ^@ http://purl.uniprot.org/uniprot/A0A2R9A2B9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Mitochondrion matrix http://togogenome.org/gene/9597:CTNNBL1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZG40 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:NFU1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BC51 ^@ Similarity ^@ Belongs to the NifU family. http://togogenome.org/gene/9597:PTPN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A014 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. http://togogenome.org/gene/9597:DLC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BQ18 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:NPPB ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the natriuretic peptide family.|||Secreted http://togogenome.org/gene/9597:GLRA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AUZ5|||http://purl.uniprot.org/uniprot/A0A2R9B148 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/9597:SH3GLB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BH85|||http://purl.uniprot.org/uniprot/A0A2R9BQX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Golgi apparatus membrane|||Midbody|||Mitochondrion outer membrane|||autophagosome membrane http://togogenome.org/gene/9597:CBX3 ^@ http://purl.uniprot.org/uniprot/A0A2R9C2U0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:LOC100992309 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z5M7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9597:HMMR ^@ http://purl.uniprot.org/uniprot/A0A2R9ANT3 ^@ Subcellular Location Annotation ^@ spindle http://togogenome.org/gene/9597:ADPRH ^@ http://purl.uniprot.org/uniprot/A0A2R9BJB4 ^@ Similarity ^@ Belongs to the ADP-ribosylglycohydrolase family. http://togogenome.org/gene/9597:FABP4 ^@ http://purl.uniprot.org/uniprot/A0A2R9APP5 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9597:ACAD11 ^@ http://purl.uniprot.org/uniprot/A0A2R9BXK0 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9597:TFB2M ^@ http://purl.uniprot.org/uniprot/A0A2R9BBG1 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:PSMB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BX98 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:INKA2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INKA family.|||Nucleus http://togogenome.org/gene/9597:THRSP ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPOT14 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:MRPL18 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6M7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL18 family. http://togogenome.org/gene/9597:CAPN6 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZK0 ^@ Caution|||Similarity ^@ Belongs to the peptidase C2 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:TATDN3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJF7 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. http://togogenome.org/gene/9597:EXOC4 ^@ http://purl.uniprot.org/uniprot/A0A2R9B539 ^@ Function|||Similarity ^@ Belongs to the SEC8 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/9597:CYP4X1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B681 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9597:INO80 ^@ http://purl.uniprot.org/uniprot/A0A2R9CAE3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.|||Belongs to the SNF2/RAD54 helicase family.|||Component of the INO80 chromatin-remodeling complex.|||Nucleus|||The DBINO region is involved in binding to DNA. http://togogenome.org/gene/9597:MTMR4 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5A9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/9597:LEPROT ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OB-RGRP/VPS55 family.|||Membrane http://togogenome.org/gene/9597:MAP1LC3C ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQI5 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9597:FUZ ^@ http://purl.uniprot.org/uniprot/A0A2R9CJT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fuzzy family.|||cytoskeleton http://togogenome.org/gene/9597:MEGF10 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUG2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:SPARC ^@ http://purl.uniprot.org/uniprot/A0A2R9BZI6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.|||Belongs to the SPARC family.|||Membrane|||basement membrane http://togogenome.org/gene/9597:IL25 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZT80 ^@ Similarity ^@ Belongs to the IL-17 family. http://togogenome.org/gene/9597:TOP3B ^@ http://purl.uniprot.org/uniprot/A0A2R9BLW1|||http://purl.uniprot.org/uniprot/A0A2R9BLW2 ^@ Function|||Similarity ^@ Belongs to the type IA topoisomerase family.|||Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. http://togogenome.org/gene/9597:FAM83D ^@ http://purl.uniprot.org/uniprot/A0A2R9BBD9 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9597:UGGT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BDQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 8 family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9597:MGMT ^@ http://purl.uniprot.org/uniprot/A0A2R8ZW16 ^@ Function|||Similarity ^@ Belongs to the MGMT family.|||Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. http://togogenome.org/gene/9597:TPM2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AEL6|||http://purl.uniprot.org/uniprot/A0A2R9AEL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9597:LOC100976413 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAQ6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL6 family. http://togogenome.org/gene/9597:ATP5PF ^@ http://purl.uniprot.org/uniprot/A0A2R9B379 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ATPase subunit F6 family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.|||Mitochondrion|||Mitochondrion inner membrane http://togogenome.org/gene/9597:MCL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Cytoplasm|||nucleoplasm http://togogenome.org/gene/9597:TSPAN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4W3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9597:SLC5A6 ^@ http://purl.uniprot.org/uniprot/A0A2R9BV55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:AVIL ^@ http://purl.uniprot.org/uniprot/A0A2R9CR49 ^@ Similarity ^@ Belongs to the villin/gelsolin family. http://togogenome.org/gene/9597:DDX49 ^@ http://purl.uniprot.org/uniprot/A0A2R9BAA4 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9597:DR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZU21 ^@ Similarity ^@ Belongs to the NC2 beta/DR1 family. http://togogenome.org/gene/9597:CORO1B ^@ http://purl.uniprot.org/uniprot/A0A2R9A938 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/9597:CD63 ^@ http://purl.uniprot.org/uniprot/A0A2R9C3C8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Cell membrane|||Cell surface|||Endosome membrane|||Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.|||Late endosome membrane|||Lysosome membrane|||Melanosome|||Membrane|||extracellular exosome|||multivesicular body http://togogenome.org/gene/9597:RRM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BPQ4 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/9597:EDC4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AW25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat EDC4 family.|||P-body http://togogenome.org/gene/9597:HTRA4 ^@ http://purl.uniprot.org/uniprot/A0A2R9ATF4 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/9597:DNMT3B ^@ http://purl.uniprot.org/uniprot/A0A2R9AZX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.|||Nucleus http://togogenome.org/gene/9597:LOC100990167 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6E1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9597:SLC1A7 ^@ http://purl.uniprot.org/uniprot/A0A2R9BL66 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:SCOC ^@ http://purl.uniprot.org/uniprot/A0A2R9CFR9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SCOC family.|||Positive regulator of amino acid starvation-induced autophagy.|||trans-Golgi network http://togogenome.org/gene/9597:CCL24 ^@ http://purl.uniprot.org/uniprot/A0A2R9A0T6 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9597:GANAB ^@ http://purl.uniprot.org/uniprot/A0A2R9CH45|||http://purl.uniprot.org/uniprot/A0A2R9CH92 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/9597:PSMA1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZB28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1A family.|||Nucleus http://togogenome.org/gene/9597:RBP4 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9Q7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family.|||Interacts with TTR.|||Retinol-binding protein that mediates retinol transport in blood plasma.|||Secreted http://togogenome.org/gene/9597:CDH19 ^@ http://purl.uniprot.org/uniprot/A0A2R9BH09 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:ZSCAN18 ^@ http://purl.uniprot.org/uniprot/A0A2R9ALY8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:CC2D1B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZA86|||http://purl.uniprot.org/uniprot/A0A2R8ZGZ6 ^@ Similarity ^@ Belongs to the CC2D1 family. http://togogenome.org/gene/9597:SERPINA6 ^@ http://purl.uniprot.org/uniprot/A0A2R9CH07 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9597:STARD5 ^@ http://purl.uniprot.org/uniprot/A0A2R9C3H0 ^@ Function ^@ May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols. http://togogenome.org/gene/9597:CWF19L2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSA2 ^@ Similarity ^@ Belongs to the CWF19 family. http://togogenome.org/gene/9597:MYH2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C3D0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9597:B4GALT1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BQS0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9597:SLC46A2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C667 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:PTCH1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the patched family.|||Membrane http://togogenome.org/gene/9597:YEATS4 ^@ http://purl.uniprot.org/uniprot/A0A2R9ALU4|||http://purl.uniprot.org/uniprot/A0A2R9ATU1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:LYRM7 ^@ http://purl.uniprot.org/uniprot/A0A2R9AT14 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.|||Belongs to the complex I LYR family.|||Interacts with UQCRFS1.|||Mitochondrion matrix http://togogenome.org/gene/9597:RPIA ^@ http://purl.uniprot.org/uniprot/A0A2R9CP46 ^@ Similarity ^@ Belongs to the ribose 5-phosphate isomerase family. http://togogenome.org/gene/9597:NOB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C8W4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOB1 family.|||May play a role in mRNA degradation.|||Nucleus http://togogenome.org/gene/9597:PXMP4 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1K1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Interacts with PEX19.|||Peroxisome membrane http://togogenome.org/gene/9597:PNRC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C2P9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:RNF185 ^@ http://purl.uniprot.org/uniprot/A0A2R9CA07 ^@ Domain|||Function|||Subcellular Location Annotation ^@ E3 ubiquitin-protein ligase.|||Endoplasmic reticulum membrane|||Mitochondrion membrane|||The RING-type zinc finger domain is responsible for E3 ligase activity. http://togogenome.org/gene/9597:FOXO4 ^@ http://purl.uniprot.org/uniprot/A0A2R9ANH7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:FBP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AWW0 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/9597:RNF34 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBE4 ^@ Subcellular Location Annotation ^@ Cell membrane|||cytosol http://togogenome.org/gene/9597:LOC100979946 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGT9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:PLPP5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZXL0|||http://purl.uniprot.org/uniprot/A0A2R9A220 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9597:KCNE4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AVN5 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/9597:NELL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ANA0|||http://purl.uniprot.org/uniprot/A0A2R9AQI0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:PTGER3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CQ64 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:LRRFIP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZX94 ^@ Similarity ^@ Belongs to the LRRFIP family. http://togogenome.org/gene/9597:PRKG2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C2R9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily. http://togogenome.org/gene/9597:TMEM233 ^@ http://purl.uniprot.org/uniprot/A0A2R9A5H0 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9597:PAQR5 ^@ http://purl.uniprot.org/uniprot/A0A2R9CIC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9597:ARL5A ^@ http://purl.uniprot.org/uniprot/A0A2R9AT82 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9597:FICD ^@ http://purl.uniprot.org/uniprot/A0A2R9AM27 ^@ Similarity ^@ Belongs to the fic family. http://togogenome.org/gene/9597:SFRP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AN78 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:FAN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9I5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAN1 family.|||Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.|||Nucleus http://togogenome.org/gene/9597:CTPS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJL3 ^@ Function|||Similarity ^@ Belongs to the CTP synthase family.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. http://togogenome.org/gene/9597:LCE3C ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHF2 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9597:FTSJ3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZT53 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.|||Interacts with NIP7.|||Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.|||nucleolus http://togogenome.org/gene/9597:SCAMP3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A3I7|||http://purl.uniprot.org/uniprot/A0A2R9A4P8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/9597:LOC100977427 ^@ http://purl.uniprot.org/uniprot/A0A2R9CF39 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/9597:HLX ^@ http://purl.uniprot.org/uniprot/A0A2R9APK8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:DCLRE1A ^@ http://purl.uniprot.org/uniprot/A0A2R9CJR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/9597:CASTOR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AUD1|||http://purl.uniprot.org/uniprot/A0A2R9AUD4 ^@ Similarity ^@ Belongs to the GATS family. http://togogenome.org/gene/9597:ADD3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BHX0|||http://purl.uniprot.org/uniprot/A0A2R9BLF9 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/9597:HECTD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BBJ8 ^@ Function|||Similarity ^@ Belongs to the UPL family. K-HECT subfamily.|||E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. http://togogenome.org/gene/9597:LOC100982788 ^@ http://purl.uniprot.org/uniprot/A0A2R9AE21 ^@ Similarity ^@ Belongs to the PRAME family. http://togogenome.org/gene/9597:IL17RB ^@ http://purl.uniprot.org/uniprot/A0A2R9C6Y5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:SLC10A3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B8V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/9597:TGM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AAS4 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9597:JAK2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.|||Cytoplasm|||Endomembrane system|||Nucleus http://togogenome.org/gene/9597:THBS4 ^@ http://purl.uniprot.org/uniprot/A0A2R9B1Q9 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:CD9 ^@ http://purl.uniprot.org/uniprot/A0A2R9A6U5|||http://purl.uniprot.org/uniprot/A0A2R9A7Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Cell membrane|||Membrane|||extracellular exosome http://togogenome.org/gene/9597:HOXB8 ^@ http://purl.uniprot.org/uniprot/A0A2R9B7H4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:TNFRSF11B ^@ http://purl.uniprot.org/uniprot/A0A2R9AB16 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:ALAS2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZRC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:TMEM225 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZJR8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:B3GALT1 ^@ http://purl.uniprot.org/uniprot/Q7JK25 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins.|||Golgi apparatus membrane http://togogenome.org/gene/9597:ELAVL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7L0 ^@ Similarity ^@ Belongs to the RRM elav family. http://togogenome.org/gene/9597:ABCA8 ^@ http://purl.uniprot.org/uniprot/A0A2R9BXN9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:ISOC2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLI5|||http://purl.uniprot.org/uniprot/A0A2R8ZNA2 ^@ Similarity ^@ Belongs to the isochorismatase family. http://togogenome.org/gene/9597:AARS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C0B8 ^@ Cofactor|||Domain|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||ISGylated.|||Monomer. Interacts with ANKRD16; the interaction is direct. http://togogenome.org/gene/9597:INHBA ^@ http://purl.uniprot.org/uniprot/A0A2R9BD91 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/9597:SERPINA5 ^@ http://purl.uniprot.org/uniprot/A0A2R9AU45 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9597:CSNK1A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4S3|||http://purl.uniprot.org/uniprot/A0A2R9CFB2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:PTAR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZXR4 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family. http://togogenome.org/gene/9597:RPTOR ^@ http://purl.uniprot.org/uniprot/A0A2R9CM07 ^@ Similarity ^@ Belongs to the WD repeat RAPTOR family. http://togogenome.org/gene/9597:ACSL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B8E0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.|||Endoplasmic reticulum membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9597:AATK ^@ http://purl.uniprot.org/uniprot/A0A2R8Z5V2 ^@ Caution|||Similarity ^@ Belongs to the globin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:HOXB13 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9597:PSMC6 ^@ http://purl.uniprot.org/uniprot/A0A2R9AV98 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9597:NR4A2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AK54 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family.|||Cytoplasm|||Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.|||Nucleus http://togogenome.org/gene/9597:ZNF251 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZAD2 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:MICAL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C430 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mical family.|||Cytoplasm http://togogenome.org/gene/9597:MAP4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CE05 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9597:SLITRK3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZS61 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9597:PSEN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSY5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A22A family.|||Cytoplasmic granule|||Early endosome membrane|||Endoplasmic reticulum membrane|||Endosome membrane|||Golgi apparatus membrane|||Homodimer.|||Membrane|||Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.|||Synapse|||The PAL motif is required for normal active site conformation.|||axon|||neuron projection http://togogenome.org/gene/9597:INTS14 ^@ http://purl.uniprot.org/uniprot/A0A2R9AG12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INTS14 family.|||Nucleus|||Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. http://togogenome.org/gene/9597:LDB2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ATR9 ^@ Similarity ^@ Belongs to the LDB family. http://togogenome.org/gene/9597:ALDOC ^@ http://purl.uniprot.org/uniprot/A0A2R9CJB4 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/9597:BMPR1B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9597:AMDHD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C3J0 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. HutI family. http://togogenome.org/gene/9597:TPX2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AHE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TPX2 family.|||Nucleus|||spindle pole http://togogenome.org/gene/9597:MCTS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C406|||http://purl.uniprot.org/uniprot/A0A2R9C412 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCTS1 family.|||Cytoplasm http://togogenome.org/gene/9597:MAPRE1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||cytoskeleton http://togogenome.org/gene/9597:GJB5 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZL18 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9597:GGPS1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AIF6 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9597:LOC100976458 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDA8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:SLC34A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AL66 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the SLC34A transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:ALDH18A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9C489 ^@ Similarity ^@ In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.|||In the N-terminal section; belongs to the glutamate 5-kinase family. http://togogenome.org/gene/9597:TSPAN8 ^@ http://purl.uniprot.org/uniprot/A0A2R9A5W4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9597:PPIL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AF43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.|||Nucleus http://togogenome.org/gene/9597:GPR37L1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BEY8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:PLA2G3 ^@ http://purl.uniprot.org/uniprot/A0A2R9A6K1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Secreted http://togogenome.org/gene/9597:KHDRBS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ANP4 ^@ Similarity ^@ Belongs to the KHDRBS family. http://togogenome.org/gene/9597:CSNK1D ^@ http://purl.uniprot.org/uniprot/A0A2R8ZMP8|||http://purl.uniprot.org/uniprot/A0A2R8ZQJ6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9597:NT5C3B ^@ http://purl.uniprot.org/uniprot/A0A2R9B9B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrimidine 5'-nucleotidase family.|||Cytoplasm http://togogenome.org/gene/9597:UBA6 ^@ http://purl.uniprot.org/uniprot/A0A2R9B8U5 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/9597:FARSA ^@ http://purl.uniprot.org/uniprot/A0A2R9AYM6 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily. http://togogenome.org/gene/9597:LOC100992621 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKJ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:NUP107 ^@ http://purl.uniprot.org/uniprot/A0A2R9AD58 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nucleoporin Nup84/Nup107 family.|||Functions as a component of the nuclear pore complex (NPC).|||Nucleus membrane|||Part of the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/9597:NDUFB10 ^@ http://purl.uniprot.org/uniprot/A0A2R9C0U8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.|||Belongs to the complex I NDUFB10 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9597:LOC100982169 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPT0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9597:ZNF473 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZNU2 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:ACTA2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9G7 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9597:E2F2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C653 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9597:PFDN6 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZT15 ^@ Function|||Similarity ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. http://togogenome.org/gene/9597:SLC7A6OS ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9J6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IWR1/SLC7A6OS family.|||Cytoplasm|||Directs RNA polymerase II nuclear import.|||Nucleus http://togogenome.org/gene/9597:TLE1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BI74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat Groucho/TLE family.|||Nucleus http://togogenome.org/gene/9597:TMEM39A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM39 family.|||Membrane http://togogenome.org/gene/9597:USP14 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFF6|||http://purl.uniprot.org/uniprot/A0A2R8ZLW5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the peptidase C19 family. USP14/UBP6 subfamily.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Interacts with TRIM14; this interaction recruits USP14 to cleave ubiquitin chains of CGAS. http://togogenome.org/gene/9597:PCNA ^@ http://purl.uniprot.org/uniprot/A0A2R9AYV6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PCNA family.|||Nucleus|||This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. http://togogenome.org/gene/9597:CD320 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJ50 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:RAB9A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||phagosome membrane http://togogenome.org/gene/9597:LAMTOR3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B362 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR3 family.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/9597:ERO1A ^@ http://purl.uniprot.org/uniprot/A0A2R9BD26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EROs family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9597:LAPTM4B ^@ http://purl.uniprot.org/uniprot/A0A2R9B9Q7 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/9597:TPH2 ^@ http://purl.uniprot.org/uniprot/A0A2R9ACE6 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/9597:GPR183 ^@ http://purl.uniprot.org/uniprot/A0A2R9AV50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:CPLANE2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A6W2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.|||cilium basal body http://togogenome.org/gene/9597:BECN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BK26 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.|||Belongs to the beclin family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Endosome membrane|||Membrane|||Mitochondrion membrane|||Plays a central role in autophagy.|||autophagosome|||trans-Golgi network membrane http://togogenome.org/gene/9597:MRPL44 ^@ http://purl.uniprot.org/uniprot/A0A2R9AMW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.|||Mitochondrion http://togogenome.org/gene/9597:UBE3A ^@ http://purl.uniprot.org/uniprot/A0A2R9BJP4 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.|||Nucleus http://togogenome.org/gene/9597:LOC100988774 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGQ6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:FITM2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BEX8 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:LOC100993774 ^@ http://purl.uniprot.org/uniprot/A0A2R9A7T2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:ANTXR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BPT3|||http://purl.uniprot.org/uniprot/A0A2R9BPU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATR family.|||Membrane http://togogenome.org/gene/9597:SMIM22 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPC4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:HOXA1 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z5Q4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Labial subfamily.|||Nucleus http://togogenome.org/gene/9597:NAT10 ^@ http://purl.uniprot.org/uniprot/A0A2R9B8I8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.|||Interacts with THUMPD1.|||RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.|||nucleolus http://togogenome.org/gene/9597:HJV ^@ http://purl.uniprot.org/uniprot/A0A2R9C0L7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the repulsive guidance molecule (RGM) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:NFIX ^@ http://purl.uniprot.org/uniprot/A0A2R8ZVN3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTF/NF-I family.|||Binds DNA as a homodimer.|||Nucleus|||Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. http://togogenome.org/gene/9597:DHPS ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKK2 ^@ Similarity ^@ Belongs to the deoxyhypusine synthase family. http://togogenome.org/gene/9597:MRPL32 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSZ9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/9597:MRPL40 ^@ http://purl.uniprot.org/uniprot/A0A2R9AAU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL40 family.|||Mitochondrion http://togogenome.org/gene/9597:WDR83OS ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEE2 ^@ Similarity ^@ Belongs to the Asterix family. http://togogenome.org/gene/9597:TRIQK ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIQK family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:RAB4A ^@ http://purl.uniprot.org/uniprot/A0A2R9BBV5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. http://togogenome.org/gene/9597:LY6D ^@ http://purl.uniprot.org/uniprot/A0A2R9C091 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:ZNF425 ^@ http://purl.uniprot.org/uniprot/A0A2R9CAB5 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:UFM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AIR5|||http://purl.uniprot.org/uniprot/A0A2R9AML1 ^@ Function|||Similarity ^@ Belongs to the UFM1 family.|||Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. http://togogenome.org/gene/9597:SPAG9 ^@ http://purl.uniprot.org/uniprot/A0A2R9B798|||http://purl.uniprot.org/uniprot/A0A2R9B8Q4 ^@ Similarity ^@ Belongs to the JIP scaffold family. http://togogenome.org/gene/9597:RTRAF ^@ http://purl.uniprot.org/uniprot/A0A2R9AEQ8 ^@ Similarity ^@ Belongs to the RTRAF family. http://togogenome.org/gene/9597:LIPN ^@ http://purl.uniprot.org/uniprot/A0A2R9B1I6 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9597:LOC100992900 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZP79 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9597:LOC100969613 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZER1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:CAPN1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZV69 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9597:GKAP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A277 ^@ Similarity ^@ Belongs to the GKAP1 family. http://togogenome.org/gene/9597:DYSF ^@ http://purl.uniprot.org/uniprot/A0A2R9B7D1|||http://purl.uniprot.org/uniprot/A0A2R9BB58|||http://purl.uniprot.org/uniprot/A0A2R9BB65|||http://purl.uniprot.org/uniprot/A0A2R9BB95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ferlin family.|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/9597:EIF5A ^@ http://purl.uniprot.org/uniprot/A0A2R9AUC9|||http://purl.uniprot.org/uniprot/A0A2R9AUE3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Endoplasmic reticulum membrane|||Membrane|||Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.|||eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group. http://togogenome.org/gene/9597:PTHLH ^@ http://purl.uniprot.org/uniprot/A0A2R8ZWR6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the parathyroid hormone family.|||Cytoplasm|||Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath.|||Nucleus|||Osteostatin is a potent inhibitor of osteoclastic bone resorption.|||PTHrP interacts with PTH1R (via N-terminal extracellular domain).|||Secreted|||There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions. http://togogenome.org/gene/9597:SERPING1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BXU2 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9597:TOP3A ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPA3 ^@ Function|||Similarity ^@ Belongs to the type IA topoisomerase family.|||Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. http://togogenome.org/gene/9597:JAG1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZ83 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/9597:ZNF34 ^@ http://purl.uniprot.org/uniprot/A0A2R9AP39 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:PBX1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/PBX homeobox family.|||Nucleus http://togogenome.org/gene/9597:PPP4R3B ^@ http://purl.uniprot.org/uniprot/A0A2R9BBC1 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/9597:SV2A ^@ http://purl.uniprot.org/uniprot/A0A2R9A117 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/9597:AGO1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B1M6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the argonaute family.|||P-body http://togogenome.org/gene/9597:PUS7 ^@ http://purl.uniprot.org/uniprot/A0A2R9CIV4 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruD family. http://togogenome.org/gene/9597:ACVRL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BCM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9597:ITGA2B ^@ http://purl.uniprot.org/uniprot/A0A2R9BZL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9597:TARDBP ^@ http://purl.uniprot.org/uniprot/A0A2R9C1F8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:PUS3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSK3 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/9597:TCEANC ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLV7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:LOC100980196 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZG66 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:KIF20B ^@ http://purl.uniprot.org/uniprot/A0A2R9AGE3 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9597:HNRNPA3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSN7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:MRPS18A ^@ http://purl.uniprot.org/uniprot/A0A2R9B9W1|||http://purl.uniprot.org/uniprot/A0A2R9BDJ8 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9597:TARS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9N8|||http://purl.uniprot.org/uniprot/A0A2R9CCD5 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9597:IRF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BBG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Nucleus http://togogenome.org/gene/9597:ANKZF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AIQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ANKZF1/VMS1 family.|||Cytoplasm http://togogenome.org/gene/9597:SNCB ^@ http://purl.uniprot.org/uniprot/A0A2R9B721 ^@ Similarity ^@ Belongs to the synuclein family. http://togogenome.org/gene/9597:C12H12orf57 ^@ http://purl.uniprot.org/uniprot/A0A2R9CN26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0456 family.|||Cytoplasm http://togogenome.org/gene/9597:SLC17A2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CIB8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:CSTF1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSV4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:ATAD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJ26 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9597:TP53BP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BY56|||http://purl.uniprot.org/uniprot/A0A2R9BY74 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:USP15 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6R4|||http://purl.uniprot.org/uniprot/A0A2R8Z6S5|||http://purl.uniprot.org/uniprot/A0A2R8Z6U6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Cytoplasm|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Nucleus http://togogenome.org/gene/9597:TNFRSF21 ^@ http://purl.uniprot.org/uniprot/A0A2R9ADT6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:TUBG1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A2E7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin family.|||Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.|||centrosome http://togogenome.org/gene/9597:CFAP97D1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZX8 ^@ Similarity ^@ Belongs to the CFAP97 family. http://togogenome.org/gene/9597:ZNF621 ^@ http://purl.uniprot.org/uniprot/A0A2R9CQ47 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:DDX47 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5R5 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9597:ADGRD1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIA6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:PON3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AP95 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit.|||Glycosylated. http://togogenome.org/gene/9597:PRUNE2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AC58 ^@ Similarity ^@ Belongs to the PPase class C family. Prune subfamily. http://togogenome.org/gene/9597:ALG9 ^@ http://purl.uniprot.org/uniprot/A0A2R9BWM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9597:BMP5 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z8H0 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9597:RPS27L ^@ http://purl.uniprot.org/uniprot/A0A2R8ZTE7 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9597:HOXB5 ^@ http://purl.uniprot.org/uniprot/A0A2R9C1J4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9597:BCL2L1 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Membrane|||Mitochondrion matrix|||Nucleus membrane|||centrosome|||cytosol|||synaptic vesicle membrane http://togogenome.org/gene/9597:LOC100975326 ^@ http://purl.uniprot.org/uniprot/A0A2R9B185 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/9597:COQ10B ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBB5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the COQ10 family.|||Interacts with coenzyme Q.|||Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. http://togogenome.org/gene/9597:TAF1L ^@ http://purl.uniprot.org/uniprot/A0A2R8Z796 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF1 family.|||Nucleus http://togogenome.org/gene/9597:NUCB2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7N7 ^@ Similarity ^@ Belongs to the nucleobindin family. http://togogenome.org/gene/9597:ZMYND10 ^@ http://purl.uniprot.org/uniprot/A0A2R9AMK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the ZMYND10 family.|||Dynein axonemal particle|||Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.|||centriolar satellite http://togogenome.org/gene/9597:DNM1L ^@ http://purl.uniprot.org/uniprot/A0A2R9BXC8|||http://purl.uniprot.org/uniprot/A0A2R9C0R1 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/9597:MS4A12 ^@ http://purl.uniprot.org/uniprot/A0A2R9CH32 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9597:HSPA8 ^@ http://purl.uniprot.org/uniprot/A0A2R9C3N8 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9597:DOK5 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJH7 ^@ Similarity ^@ Belongs to the DOK family. Type B subfamily. http://togogenome.org/gene/9597:ZNF552 ^@ http://purl.uniprot.org/uniprot/A0A2R9BZF3 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:LOC100986973 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQM1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9597:LYPLAL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSN0 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/9597:IKBKE ^@ http://purl.uniprot.org/uniprot/A0A2R9BQ59 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:EIF2AK3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BQ98 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9597:CD53 ^@ http://purl.uniprot.org/uniprot/A0A2R9BVP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9597:LOC100987752 ^@ http://purl.uniprot.org/uniprot/A0A2R9A8N7 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9597:MCOLN1 ^@ http://purl.uniprot.org/uniprot/A0A2R9B983 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9597:NAA40 ^@ http://purl.uniprot.org/uniprot/A0A2R9AEI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. NAA40 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:PLAC8L1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BDR7 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/9597:SNX32 ^@ http://purl.uniprot.org/uniprot/A0A2R9C9I1 ^@ Function|||Similarity ^@ Belongs to the sorting nexin family.|||Involved in several stages of intracellular trafficking. http://togogenome.org/gene/9597:EEF1D ^@ http://purl.uniprot.org/uniprot/A0A2R8ZI37|||http://purl.uniprot.org/uniprot/A0A2R8ZI39 ^@ Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family. http://togogenome.org/gene/9597:PSMB5 ^@ http://purl.uniprot.org/uniprot/A0A2R9CFM6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9597:CYP7A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CLT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9597:SLC44A4 ^@ http://purl.uniprot.org/uniprot/A0A2R9C317 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/9597:GPD1L ^@ http://purl.uniprot.org/uniprot/A0A2R9BQF2 ^@ Similarity ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/9597:CPLX3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CGT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9597:ACTL9 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZEN5 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9597:NGFR ^@ http://purl.uniprot.org/uniprot/A0A2R9BW44 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:VDAC3 ^@ http://purl.uniprot.org/uniprot/A0A2R9B3E1 ^@ Similarity ^@ Belongs to the eukaryotic mitochondrial porin family. http://togogenome.org/gene/9597:ZDHHC21 ^@ http://purl.uniprot.org/uniprot/A0A2R9BML4 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9597:KRT35 ^@ http://purl.uniprot.org/uniprot/A0A2R9ATZ6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9597:NME6 ^@ http://purl.uniprot.org/uniprot/A0A2R9BF56 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9597:ZNF26 ^@ http://purl.uniprot.org/uniprot/A0A2R9CFY8|||http://purl.uniprot.org/uniprot/A0A2R9CG19 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:PALS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BAP0 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/9597:MC4R ^@ http://purl.uniprot.org/uniprot/C3U0E1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). http://togogenome.org/gene/9597:ACRBP ^@ http://purl.uniprot.org/uniprot/A0A2R9CE14 ^@ Subcellular Location Annotation ^@ acrosome http://togogenome.org/gene/9597:RC3H2 ^@ http://purl.uniprot.org/uniprot/A0A2R9B867 ^@ Subcellular Location Annotation ^@ P-body http://togogenome.org/gene/9597:PRKAR1A ^@ http://purl.uniprot.org/uniprot/A0A2R9AQD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:PROM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AWA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prominin family.|||Membrane|||microvillus membrane http://togogenome.org/gene/9597:AARS2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZCJ3 ^@ Caution|||Cofactor|||Domain|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||ISGylated.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Interacts with ANKRD16; the interaction is direct. http://togogenome.org/gene/9597:NPBWR2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AT30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:LOC100993494 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDQ9 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9597:PARVA ^@ http://purl.uniprot.org/uniprot/A0A2R9BJD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the parvin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:TRIP10 ^@ http://purl.uniprot.org/uniprot/A0A2R9AWS0|||http://purl.uniprot.org/uniprot/A0A2R9B2P4 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9597:UBE2D1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BEU3 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9597:LOC100987645 ^@ http://purl.uniprot.org/uniprot/A0A2R9AF17 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/9597:ARL6IP4 ^@ http://purl.uniprot.org/uniprot/A0A2R9A6S3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARL6IP4 family.|||Nucleus speckle|||nucleolus http://togogenome.org/gene/9597:CYP2J2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C539 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9597:DARS2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJP7 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. http://togogenome.org/gene/9597:NPY ^@ http://purl.uniprot.org/uniprot/A0A2R8ZG61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Secreted http://togogenome.org/gene/9597:REM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AB90 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/9597:SLC37A3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AVE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Membrane http://togogenome.org/gene/9597:BCL2L11 ^@ http://purl.uniprot.org/uniprot/A0A2R9CA30 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Bcl-2 family.|||Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1.|||Induces apoptosis and anoikis. http://togogenome.org/gene/9597:PIH1D2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CHJ8 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/9597:VCAN ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPX8|||http://purl.uniprot.org/uniprot/A0A2R8ZPY0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aggrecan/versican proteoglycan family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9597:LOC100967331 ^@ http://purl.uniprot.org/uniprot/A0A2R9ADB3|||http://purl.uniprot.org/uniprot/A0A2R9AIA7|||http://purl.uniprot.org/uniprot/A0A2R9AIC2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Cytoplasm|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Nucleus http://togogenome.org/gene/9597:ACTRT2 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z9G4 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9597:UNC5B ^@ http://purl.uniprot.org/uniprot/A0A2R9B4C2|||http://purl.uniprot.org/uniprot/A0A2R9B5X7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-5 family.|||Cell membrane|||Membrane|||Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. http://togogenome.org/gene/9597:TDRD5 ^@ http://purl.uniprot.org/uniprot/A0A2R9AZT9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TDRD5 family.|||Cytoplasm|||Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly. http://togogenome.org/gene/9597:UFC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BT93 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.|||E1-like enzyme which specifically catalyzes the second step in ufmylation. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. http://togogenome.org/gene/9597:EPYC ^@ http://purl.uniprot.org/uniprot/A0A2R9A7S5 ^@ Similarity ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. http://togogenome.org/gene/9597:LOC100991861 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z736 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9597:SRRT ^@ http://purl.uniprot.org/uniprot/A0A2R9C7P4 ^@ Similarity ^@ Belongs to the ARS2 family. http://togogenome.org/gene/9597:CXCR3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CB54 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Homomer. Forms heteromers with ACKR4.|||Membrane http://togogenome.org/gene/9597:PFDN2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AYJ1 ^@ Function|||Similarity ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. http://togogenome.org/gene/9597:POU5F1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BMQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/9597:SLC12A6 ^@ http://purl.uniprot.org/uniprot/A0A2R9AVG1|||http://purl.uniprot.org/uniprot/A0A2R9AVH9|||http://purl.uniprot.org/uniprot/A0A2R9AVR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9597:ACAP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BJS8|||http://purl.uniprot.org/uniprot/A0A2R9BTL9 ^@ Activity Regulation|||Domain|||Function|||Subcellular Location Annotation ^@ Endosome membrane|||GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.|||GTPase-activating protein for the ADP ribosylation factor family.|||PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.|||The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions. http://togogenome.org/gene/9597:CKLF ^@ http://purl.uniprot.org/uniprot/A0A2R8ZV93 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:UBE2D2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDE7 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9597:GNAI3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BVD2 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9597:PLPBP ^@ http://purl.uniprot.org/uniprot/A0A2R9BH12 ^@ Function|||Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.|||Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6. http://togogenome.org/gene/9597:SPDYA ^@ http://purl.uniprot.org/uniprot/A0A2R9BDL4 ^@ Similarity ^@ Belongs to the Speedy/Ringo family. http://togogenome.org/gene/9597:PTPRZ1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDB5|||http://purl.uniprot.org/uniprot/A0A2R9CFS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.|||Membrane http://togogenome.org/gene/9597:CMC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion http://togogenome.org/gene/9597:MS4A5 ^@ http://purl.uniprot.org/uniprot/A0A2R9B1W7 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9597:SHQ1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZWN5 ^@ Similarity ^@ Belongs to the SHQ1 family. http://togogenome.org/gene/9597:ZNF782 ^@ http://purl.uniprot.org/uniprot/A0A2R9BXM1 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:MICOS13 ^@ http://purl.uniprot.org/uniprot/A0A2R9BS88|||http://purl.uniprot.org/uniprot/A0A2R9BS92 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic13 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9597:BCAT2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BPT8|||http://purl.uniprot.org/uniprot/A0A2R9BV83 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9597:LOC100985111 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:LDHD ^@ http://purl.uniprot.org/uniprot/A0A2R8Z654 ^@ Similarity ^@ Belongs to the FAD-binding oxidoreductase/transferase type 4 family. http://togogenome.org/gene/9597:SLC17A8 ^@ http://purl.uniprot.org/uniprot/A0A2R9CII7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:CXCL1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AI50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9597:KIF1C ^@ http://purl.uniprot.org/uniprot/A0A2R9C1I9 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9597:MEIS2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQ82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/9597:AP3M2 ^@ http://purl.uniprot.org/uniprot/A0A2R9C5T5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus http://togogenome.org/gene/9597:IPO11 ^@ http://purl.uniprot.org/uniprot/A0A2R9CB02 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9597:TMEM131L ^@ http://purl.uniprot.org/uniprot/A0A2R9B826 ^@ Similarity ^@ Belongs to the TMEM131 family. http://togogenome.org/gene/9597:ZDHHC4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AK39 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9597:SLC13A1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/9597:FES ^@ http://purl.uniprot.org/uniprot/A0A2R9B5Q6|||http://purl.uniprot.org/uniprot/A0A2R9BB03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.|||Cell membrane|||Membrane|||cytoskeleton http://togogenome.org/gene/9597:LOC100972396 ^@ http://purl.uniprot.org/uniprot/A0A2R9APS1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:GNB5 ^@ http://purl.uniprot.org/uniprot/A0A2R9C4W7 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/9597:SPC25 ^@ http://purl.uniprot.org/uniprot/A0A2R9BSN5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the SPC25 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/9597:LGALS3BP ^@ http://purl.uniprot.org/uniprot/A0A2R9AEC1 ^@ Function|||Subcellular Location Annotation ^@ Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.|||extracellular matrix http://togogenome.org/gene/9597:GRIA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A0F2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9597:ZC3H15 ^@ http://purl.uniprot.org/uniprot/A0A2R9CPC0 ^@ Similarity ^@ Belongs to the ZC3H15/TMA46 family. http://togogenome.org/gene/9597:MCM8 ^@ http://purl.uniprot.org/uniprot/A0A2R9AVA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Chromosome|||Nucleus http://togogenome.org/gene/9597:IRGQ ^@ http://purl.uniprot.org/uniprot/A0A2R9C798 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. http://togogenome.org/gene/9597:MTFP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AYY4 ^@ Similarity ^@ Belongs to the MTFP1 family. http://togogenome.org/gene/9597:ADGRG7 ^@ http://purl.uniprot.org/uniprot/A0A2R9AN92 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:DHX58 ^@ http://purl.uniprot.org/uniprot/A0A2R9AG97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/9597:SLC6A13 ^@ http://purl.uniprot.org/uniprot/A0A2R9BYE3|||http://purl.uniprot.org/uniprot/A0A2R9BYE4 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily.|||Cell membrane|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9597:ITPRIP ^@ http://purl.uniprot.org/uniprot/A0A2R8Z6L9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITPRIP family.|||Membrane http://togogenome.org/gene/9597:POLD1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A9F5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B family.|||Nucleus http://togogenome.org/gene/9597:SCARB2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AV73 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/9597:CTSW ^@ http://purl.uniprot.org/uniprot/A0A2R9APX3 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/9597:IL5RA ^@ http://purl.uniprot.org/uniprot/A0A2R9CJI0|||http://purl.uniprot.org/uniprot/A0A2R9CM51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 5 subfamily.|||Membrane http://togogenome.org/gene/9597:NSDHL ^@ http://purl.uniprot.org/uniprot/A0A2R9BU74 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9597:S1PR1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:AGK ^@ http://purl.uniprot.org/uniprot/A0A2R9CHX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AGK family.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/9597:OLFML3 ^@ http://purl.uniprot.org/uniprot/A0A2R9BK47 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:PGM1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BID9 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/9597:TECPR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BF29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TECPR1 family.|||Lysosome membrane|||autophagosome membrane http://togogenome.org/gene/9597:TLX1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BZH0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:GLP2R ^@ http://purl.uniprot.org/uniprot/A0A2R9BLK3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:UBR2 ^@ http://purl.uniprot.org/uniprot/A0A2R9A119 ^@ Function|||Similarity ^@ Belongs to the UBR1 family.|||Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. http://togogenome.org/gene/9597:NAPRT ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPA0 ^@ Function|||PTM|||Similarity ^@ Belongs to the NAPRTase family.|||Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.|||Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. http://togogenome.org/gene/9597:ZNF75D ^@ http://purl.uniprot.org/uniprot/A0A2R9BDD6 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9597:C11H11orf54 ^@ http://purl.uniprot.org/uniprot/A0A2R9BL85 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.|||Monomer.|||Nucleus http://togogenome.org/gene/9597:GNPTAB ^@ http://purl.uniprot.org/uniprot/A0A2R9CF47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the stealth family.|||Membrane http://togogenome.org/gene/9597:UNC5D ^@ http://purl.uniprot.org/uniprot/A0A2R9CAA5|||http://purl.uniprot.org/uniprot/A0A2R9CCQ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-5 family.|||Cell membrane|||Membrane|||Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. http://togogenome.org/gene/9597:ACY1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDD7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family.|||Binds 2 Zn(2+) ions per subunit.|||Cytoplasm http://togogenome.org/gene/9597:CTLA4 ^@ http://purl.uniprot.org/uniprot/A0A2R9C7H7|||http://purl.uniprot.org/uniprot/A0A2R9CI29 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.|||Membrane http://togogenome.org/gene/9597:FXR1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BTK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMR1 family.|||Cytoplasmic ribonucleoprotein granule|||Nucleus envelope|||Postsynapse|||Synapse|||dendritic spine http://togogenome.org/gene/9597:CISD2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AS09 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CISD protein family. CISD2 subfamily.|||Binds 1 [2Fe-2S] cluster.|||Endoplasmic reticulum membrane|||Homodimer.|||Mitochondrion outer membrane|||Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. http://togogenome.org/gene/9597:PRPF31 ^@ http://purl.uniprot.org/uniprot/A0A2R9ALM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP31 family.|||Cajal body http://togogenome.org/gene/9597:ABL2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CKH6|||http://purl.uniprot.org/uniprot/A0A2R9CMY8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9597:AADACL4 ^@ http://purl.uniprot.org/uniprot/A0A2R9CKS5 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/9597:UTRN ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7A9 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9597:TAS2R38 ^@ http://purl.uniprot.org/uniprot/I0CKB7|||http://purl.uniprot.org/uniprot/Q697L6 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane|||Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.|||Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).|||Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. http://togogenome.org/gene/9597:ZBED1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZDF5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:CPQ ^@ http://purl.uniprot.org/uniprot/A0A2R9ASH8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.|||Endoplasmic reticulum|||Golgi apparatus|||Homodimer. The monomeric form is inactive while the homodimer is active.|||Lysosome http://togogenome.org/gene/9597:YAE1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZYI0 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9597:HAPSTR2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZLQ1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:ADH6 ^@ http://purl.uniprot.org/uniprot/A0A2R9B7L7 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/9597:MRC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CHH0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:TET2 ^@ http://purl.uniprot.org/uniprot/A0A2R9AW30 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TET family.|||Binds 1 Fe(2+) ion per subunit.|||Chromosome|||Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.|||The zinc ions have a structural role. http://togogenome.org/gene/9597:CDC6 ^@ http://purl.uniprot.org/uniprot/A0A2R9BWL4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC6/cdc18 family.|||Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.|||Nucleus http://togogenome.org/gene/9597:MRPL9 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZM47 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family. http://togogenome.org/gene/9597:ADA ^@ http://purl.uniprot.org/uniprot/A0A2R8ZN08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.|||Cell junction|||Cell membrane|||Cytoplasmic vesicle lumen http://togogenome.org/gene/9597:TNC ^@ http://purl.uniprot.org/uniprot/A0A2R9AU43 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tenascin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9597:LOC100971312 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBV4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:LOC103785277 ^@ http://purl.uniprot.org/uniprot/A0A2R9CTM4 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:TRPC4 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZRZ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:STC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9A5G4 ^@ Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9597:LOC100971251 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z742 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:ZNF287 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXM9 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9597:MARK4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AJS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||dendrite http://togogenome.org/gene/9597:LOC100967628 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZPZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9597:SFXN4 ^@ http://purl.uniprot.org/uniprot/A0A2R9B6S0|||http://purl.uniprot.org/uniprot/A0A2R9B890 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Membrane http://togogenome.org/gene/9597:ZNF215 ^@ http://purl.uniprot.org/uniprot/A0A2R9B819 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9597:MAP1LC3A ^@ http://purl.uniprot.org/uniprot/A0A2R9BFU8 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9597:PCDHB5 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z686 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9597:GJD2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZQX9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9597:RNF4 ^@ http://purl.uniprot.org/uniprot/A0A2R9B9L8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:ANO3 ^@ http://purl.uniprot.org/uniprot/A0A2R9AXZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:GSDME ^@ http://purl.uniprot.org/uniprot/A0A2R8ZIJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gasdermin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9597:PLD3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZHK7 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/9597:DKK4 ^@ http://purl.uniprot.org/uniprot/A0A2R9AUV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/9597:GPR18 ^@ http://purl.uniprot.org/uniprot/A0A2R9AP23 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9597:LIMD1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZSS5 ^@ Similarity ^@ Belongs to the zyxin/ajuba family. http://togogenome.org/gene/9597:PRKCH ^@ http://purl.uniprot.org/uniprot/A0A2R9AS27 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis.|||Cytoplasm|||Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-513 (activation loop of the kinase domain), Thr-656 (turn motif) and Ser-675 (hydrophobic region), need to be phosphorylated for its full activation. http://togogenome.org/gene/9597:KHDC1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CIQ5 ^@ Similarity ^@ Belongs to the KHDC1 family. http://togogenome.org/gene/9597:HIBADH ^@ http://purl.uniprot.org/uniprot/A0A2R9CNE8 ^@ Similarity ^@ Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily. http://togogenome.org/gene/9597:KIF5B ^@ http://purl.uniprot.org/uniprot/A0A2R9A2Q6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9597:LOC100985433 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZR86 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9597:LOC100988917 ^@ http://purl.uniprot.org/uniprot/A0A2R9CC73 ^@ Similarity ^@ Belongs to the histone H2B family. http://togogenome.org/gene/9597:PTPRB ^@ http://purl.uniprot.org/uniprot/A0A2R9C722|||http://purl.uniprot.org/uniprot/A0A2R9C9S7 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily. http://togogenome.org/gene/9597:HOXB9 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZZY4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/9597:KIN ^@ http://purl.uniprot.org/uniprot/A0A2R9BFF5 ^@ Similarity ^@ Belongs to the KIN17 family. http://togogenome.org/gene/9597:SYNDIG1L ^@ http://purl.uniprot.org/uniprot/A0A2R9BLP2 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9597:NLRP8 ^@ http://purl.uniprot.org/uniprot/A0A2R9ABB7 ^@ Similarity ^@ Belongs to the NLRP family. http://togogenome.org/gene/9597:GDF2 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZGL7 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9597:SELL ^@ http://purl.uniprot.org/uniprot/A0A2R9AMF2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the selectin/LECAM family.|||Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.|||Cell membrane|||Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9597:GNB1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BKA7 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/9597:LHX9 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z7U1|||http://purl.uniprot.org/uniprot/A0A2R8Z7Z9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9597:GLI2 ^@ http://purl.uniprot.org/uniprot/A0A2R9BF82 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/9597:FGFBP1 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZKV9 ^@ Similarity ^@ Belongs to the fibroblast growth factor-binding protein family. http://togogenome.org/gene/9597:IKBKB ^@ http://purl.uniprot.org/uniprot/A0A2R9B3R9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9597:AKAP4 ^@ http://purl.uniprot.org/uniprot/A0A2R9B4P4 ^@ Similarity ^@ Belongs to the AKAP110 family. http://togogenome.org/gene/9597:LOC100979352 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZT69 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Odorant receptor. http://togogenome.org/gene/9597:MS4A8 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZK50 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9597:GTPBP10 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZUW5 ^@ Similarity ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. http://togogenome.org/gene/9597:ZNF317 ^@ http://purl.uniprot.org/uniprot/A0A2R9B2Z8|||http://purl.uniprot.org/uniprot/A0A2R9B303 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:CLDN19 ^@ http://purl.uniprot.org/uniprot/A0A2R9BUY2|||http://purl.uniprot.org/uniprot/A0A2R9BYC0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9597:RPRD1B ^@ http://purl.uniprot.org/uniprot/A0A2R9AGD3 ^@ Function|||Similarity|||Subunit ^@ Associates with the RNA polymerase II complex.|||Belongs to the UPF0400 (RTT103) family.|||Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. http://togogenome.org/gene/9597:ACER3 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZFR3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Membrane http://togogenome.org/gene/9597:GORASP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9BG14 ^@ Similarity ^@ Belongs to the GORASP family. http://togogenome.org/gene/9597:DNTTIP2 ^@ http://purl.uniprot.org/uniprot/A0A2R9CP59 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9597:ANXA1 ^@ http://purl.uniprot.org/uniprot/A0A2R9AD24 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Basolateral cell membrane|||Belongs to the annexin family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Early endosome|||Endosome membrane|||Lateral cell membrane|||Membrane|||Nucleus|||The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.|||cilium|||extracellular exosome|||extracellular space|||phagocytic cup|||secretory vesicle lumen http://togogenome.org/gene/9597:PDGFC ^@ http://purl.uniprot.org/uniprot/A0A2R9BRW3 ^@ Caution|||Similarity ^@ Belongs to the PDGF/VEGF growth factor family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9597:SVOP ^@ http://purl.uniprot.org/uniprot/A0A2R9A4H1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/9597:LOC100982890 ^@ http://purl.uniprot.org/uniprot/A0A2R9CDG4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c-type heme lyase family.|||Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9597:ZNF227 ^@ http://purl.uniprot.org/uniprot/A0A2R8Z8L3 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:MINPP1 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJN3 ^@ Similarity ^@ Belongs to the histidine acid phosphatase family. MINPP1 subfamily. http://togogenome.org/gene/9597:NDUFA8 ^@ http://purl.uniprot.org/uniprot/A0A2R9A4K1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA8 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/9597:ASB11 ^@ http://purl.uniprot.org/uniprot/A0A2R9A1J0|||http://purl.uniprot.org/uniprot/A0A2R9A2M1 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9597:PDK3 ^@ http://purl.uniprot.org/uniprot/A0A2R9CJ87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9597:HPSE ^@ http://purl.uniprot.org/uniprot/A0A2R9BIC6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 79 family. http://togogenome.org/gene/9597:ZNF878 ^@ http://purl.uniprot.org/uniprot/A0A2R9AE49 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/9597:ANXA4 ^@ http://purl.uniprot.org/uniprot/A0A2R9A478 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||Zymogen granule membrane http://togogenome.org/gene/9597:COQ10A ^@ http://purl.uniprot.org/uniprot/A0A2R9AWX6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the COQ10 family.|||Interacts with coenzyme Q.|||Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. http://togogenome.org/gene/9597:RNF121 ^@ http://purl.uniprot.org/uniprot/A0A2R9AR76|||http://purl.uniprot.org/uniprot/A0A2R9ARS8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9597:ALG14 ^@ http://purl.uniprot.org/uniprot/A0A2R9C2Y9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG14 family.|||Endoplasmic reticulum membrane|||Membrane|||Nucleus membrane http://togogenome.org/gene/9597:TIRAP ^@ http://purl.uniprot.org/uniprot/B3Y686 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Adapter involved in the TLR2 and TLR4 signaling pathways in the innate immune response.|||Cell membrane|||Cytoplasm|||Homodimer.|||Membrane http://togogenome.org/gene/9597:MPI ^@ http://purl.uniprot.org/uniprot/A0A2R9BP04 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the mannose-6-phosphate isomerase type 1 family.|||Binds 1 zinc ion per subunit.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/9597:ACAD8 ^@ http://purl.uniprot.org/uniprot/A0A2R8ZBF2 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9597:MED30 ^@ http://purl.uniprot.org/uniprot/A0A2R9AYC8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 30 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus