http://togogenome.org/gene/9646:LOC100474917 ^@ http://purl.uniprot.org/uniprot/D2HVS6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9646:KPNA6 ^@ http://purl.uniprot.org/uniprot/G1LMT1 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9646:LOC100480317 ^@ http://purl.uniprot.org/uniprot/D2H2C9 ^@ Similarity ^@ Belongs to the arylamine N-acetyltransferase family. http://togogenome.org/gene/9646:GINS2 ^@ http://purl.uniprot.org/uniprot/D2GWN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GINS2/PSF2 family.|||Chromosome|||Nucleus http://togogenome.org/gene/9646:PSMB3 ^@ http://purl.uniprot.org/uniprot/G1LCI0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:PLA2G3 ^@ http://purl.uniprot.org/uniprot/D2H207|||http://purl.uniprot.org/uniprot/G1LKV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Secreted http://togogenome.org/gene/9646:ACSS2 ^@ http://purl.uniprot.org/uniprot/G1LRW3 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9646:TADA3 ^@ http://purl.uniprot.org/uniprot/D2HRA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NGG1 family.|||Nucleus http://togogenome.org/gene/9646:FBN1 ^@ http://purl.uniprot.org/uniprot/G1L4Y3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fibrillin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9646:SRP19 ^@ http://purl.uniprot.org/uniprot/A0A7N5KCS8|||http://purl.uniprot.org/uniprot/G1M1S9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP19 family.|||Cytoplasm http://togogenome.org/gene/9646:TRAPPC2L ^@ http://purl.uniprot.org/uniprot/G1L0B8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||perinuclear region http://togogenome.org/gene/9646:SERPINI1 ^@ http://purl.uniprot.org/uniprot/A0A7N5P375 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9646:PIGU ^@ http://purl.uniprot.org/uniprot/G1LRI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGU family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:TRIT1 ^@ http://purl.uniprot.org/uniprot/A0A7N5P1B0 ^@ Similarity ^@ Belongs to the IPP transferase family. http://togogenome.org/gene/9646:QSOX1 ^@ http://purl.uniprot.org/uniprot/D2HFH1 ^@ Function|||Similarity ^@ Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.|||Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. http://togogenome.org/gene/9646:ACOX2 ^@ http://purl.uniprot.org/uniprot/G1M082 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/9646:STOML2 ^@ http://purl.uniprot.org/uniprot/D2I1Z7 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/9646:RIOK3 ^@ http://purl.uniprot.org/uniprot/A0A7N5K3E3|||http://purl.uniprot.org/uniprot/G1M591 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.|||Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. http://togogenome.org/gene/9646:SEPTIN3 ^@ http://purl.uniprot.org/uniprot/G1LS35 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cytoplasm|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9646:FAM83C ^@ http://purl.uniprot.org/uniprot/D2H448 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9646:TIPARP ^@ http://purl.uniprot.org/uniprot/D2HJI0 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9646:DYNLRB1 ^@ http://purl.uniprot.org/uniprot/G1LRF8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.|||Belongs to the GAMAD family.|||Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.|||cytoskeleton http://togogenome.org/gene/9646:ELMO2 ^@ http://purl.uniprot.org/uniprot/D2I5V9 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. http://togogenome.org/gene/9646:CENPL ^@ http://purl.uniprot.org/uniprot/G1MAT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-L/IML3 family.|||Nucleus http://togogenome.org/gene/9646:UBAC2 ^@ http://purl.uniprot.org/uniprot/G1LCL4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:DDX58 ^@ http://purl.uniprot.org/uniprot/D2HZI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/9646:BPNT1 ^@ http://purl.uniprot.org/uniprot/G1LU04 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/9646:ATP6V0D1 ^@ http://purl.uniprot.org/uniprot/D2H9E6 ^@ Similarity ^@ Belongs to the V-ATPase V0D/AC39 subunit family. http://togogenome.org/gene/9646:YIPF6 ^@ http://purl.uniprot.org/uniprot/A0A7N5P576 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:LOC100468187 ^@ http://purl.uniprot.org/uniprot/D2HUT4 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9646:SLC30A9 ^@ http://purl.uniprot.org/uniprot/G1M2Z1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Endoplasmic reticulum|||Membrane|||Mitochondrion membrane|||Nucleus http://togogenome.org/gene/9646:LOC100466214 ^@ http://purl.uniprot.org/uniprot/D2I7B4 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:ELK4 ^@ http://purl.uniprot.org/uniprot/D2H8T6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9646:ARAP3 ^@ http://purl.uniprot.org/uniprot/D2GUL8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:MLST8 ^@ http://purl.uniprot.org/uniprot/G1MHK1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat LST8 family.|||Cytoplasm|||Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB. Interacts with MEAK7. Interacts with SIK3.|||Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1. mTORC2 also modulates the phosphorylation of PRKCA. http://togogenome.org/gene/9646:CCDC39 ^@ http://purl.uniprot.org/uniprot/G1LX10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC39 family.|||cilium axoneme http://togogenome.org/gene/9646:FAM98A ^@ http://purl.uniprot.org/uniprot/A0A7N5JYR6 ^@ Similarity ^@ Belongs to the FAM98 family. http://togogenome.org/gene/9646:USP30 ^@ http://purl.uniprot.org/uniprot/G1MDL8 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9646:OSBPL7 ^@ http://purl.uniprot.org/uniprot/D2H549 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9646:EPDR1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JG37 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ependymin family.|||Binds anionic lipids and gangliosides at acidic pH.|||Lysosome lumen http://togogenome.org/gene/9646:FUT11 ^@ http://purl.uniprot.org/uniprot/G1MEE7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. http://togogenome.org/gene/9646:SEC11C ^@ http://purl.uniprot.org/uniprot/G1M9R6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Component of the signal peptidase complex.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:LOC100478996 ^@ http://purl.uniprot.org/uniprot/G1LMC8 ^@ Similarity ^@ Belongs to the Tango6 family. http://togogenome.org/gene/9646:LOC100468223 ^@ http://purl.uniprot.org/uniprot/G1LL82 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:CD3G ^@ http://purl.uniprot.org/uniprot/G1M3D4 ^@ Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Membrane|||The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta. http://togogenome.org/gene/9646:EPHB4 ^@ http://purl.uniprot.org/uniprot/A0A7N5KBM2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:ADPRHL1 ^@ http://purl.uniprot.org/uniprot/D2HTS3 ^@ Similarity ^@ Belongs to the ADP-ribosylglycohydrolase family. http://togogenome.org/gene/9646:ST3GAL2 ^@ http://purl.uniprot.org/uniprot/D2HFV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9646:TNFAIP1 ^@ http://purl.uniprot.org/uniprot/D2GU42 ^@ Similarity ^@ Belongs to the BACURD family. http://togogenome.org/gene/9646:TAS2R38 ^@ http://purl.uniprot.org/uniprot/G1M985 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9646:PSMC4 ^@ http://purl.uniprot.org/uniprot/G1M1U5 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9646:ERI1 ^@ http://purl.uniprot.org/uniprot/G1MC25 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:REXO4 ^@ http://purl.uniprot.org/uniprot/G1LYU7 ^@ Similarity ^@ Belongs to the REXO4 family. http://togogenome.org/gene/9646:STEAP2 ^@ http://purl.uniprot.org/uniprot/D2HE08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9646:SNTA1 ^@ http://purl.uniprot.org/uniprot/D2H8Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntrophin family.|||Cell junction|||cytoskeleton http://togogenome.org/gene/9646:ATL1 ^@ http://purl.uniprot.org/uniprot/G1LTT3 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9646:SPDEF ^@ http://purl.uniprot.org/uniprot/D2GYX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9646:CALHM4 ^@ http://purl.uniprot.org/uniprot/D2HNV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9646:CD28 ^@ http://purl.uniprot.org/uniprot/G1L897 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:LOC100477689 ^@ http://purl.uniprot.org/uniprot/D2I5Y1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:TMEM208 ^@ http://purl.uniprot.org/uniprot/G1MG15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM208 family.|||Endoplasmic reticulum membrane|||May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.|||Membrane http://togogenome.org/gene/9646:TRPT1 ^@ http://purl.uniprot.org/uniprot/D2H4U4 ^@ Function|||Similarity ^@ Belongs to the KptA/TPT1 family.|||Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate. http://togogenome.org/gene/9646:CXCL9 ^@ http://purl.uniprot.org/uniprot/A0A7N5K754 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9646:LOC100467946 ^@ http://purl.uniprot.org/uniprot/A0A7N5JI02|||http://purl.uniprot.org/uniprot/D2HXQ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LDAF1 family.|||Endoplasmic reticulum membrane|||Lipid droplet|||Membrane|||Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation. http://togogenome.org/gene/9646:RNF5 ^@ http://purl.uniprot.org/uniprot/D2I367 ^@ Domain|||Function|||Subcellular Location Annotation ^@ E3 ubiquitin-protein ligase.|||Endoplasmic reticulum membrane|||Mitochondrion membrane|||The RING-type zinc finger domain is responsible for E3 ligase activity. http://togogenome.org/gene/9646:RPL10 ^@ http://purl.uniprot.org/uniprot/D3YC00 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/9646:MINDY4 ^@ http://purl.uniprot.org/uniprot/G1LJI6 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM188 subfamily.|||Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. http://togogenome.org/gene/9646:IBSP ^@ http://purl.uniprot.org/uniprot/D2GX57 ^@ Function|||Subcellular Location Annotation ^@ Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.|||Secreted http://togogenome.org/gene/9646:LPCAT4 ^@ http://purl.uniprot.org/uniprot/D2I547 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9646:LOC100464112 ^@ http://purl.uniprot.org/uniprot/D2HWJ0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9646:CHRM2 ^@ http://purl.uniprot.org/uniprot/D2GYP2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. http://togogenome.org/gene/9646:PPP1R14B ^@ http://purl.uniprot.org/uniprot/A0A7N5P2C3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PP1 inhibitor family.|||Cytoplasm|||Inhibitor of PPP1CA. http://togogenome.org/gene/9646:RNF40 ^@ http://purl.uniprot.org/uniprot/D2HQN6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BRE1 family.|||Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.|||Nucleus http://togogenome.org/gene/9646:SEC24C ^@ http://purl.uniprot.org/uniprot/D2HEF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9646:SLC2A1 ^@ http://purl.uniprot.org/uniprot/G1L5P3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Membrane|||Photoreceptor inner segment http://togogenome.org/gene/9646:LOC100465962 ^@ http://purl.uniprot.org/uniprot/D2I6R7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:SLC16A4 ^@ http://purl.uniprot.org/uniprot/G1LYG9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:CDH7 ^@ http://purl.uniprot.org/uniprot/D2HQX2 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:C3H5orf24 ^@ http://purl.uniprot.org/uniprot/D2GVJ9 ^@ Similarity ^@ Belongs to the UPF0461 family. http://togogenome.org/gene/9646:RAB3A ^@ http://purl.uniprot.org/uniprot/D2GV26 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/9646:ELOVL5 ^@ http://purl.uniprot.org/uniprot/G1LGM8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL5 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Membrane|||dendrite http://togogenome.org/gene/9646:PSMA5 ^@ http://purl.uniprot.org/uniprot/G1LDQ6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9646:TACR2 ^@ http://purl.uniprot.org/uniprot/G1MHU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:LOC100474670 ^@ http://purl.uniprot.org/uniprot/G1MN55 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:IP6K1 ^@ http://purl.uniprot.org/uniprot/D2HEU2 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9646:LOC100472203 ^@ http://purl.uniprot.org/uniprot/D2HU47 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:PLAT ^@ http://purl.uniprot.org/uniprot/G1LFI3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9646:ALLC ^@ http://purl.uniprot.org/uniprot/G1MJF8 ^@ Function|||Similarity ^@ Belongs to the allantoicase family.|||The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals. http://togogenome.org/gene/9646:MSRA ^@ http://purl.uniprot.org/uniprot/A0A7N5KKV0 ^@ Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family. http://togogenome.org/gene/9646:LOC100471980 ^@ http://purl.uniprot.org/uniprot/D2I6T7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:ATPAF2 ^@ http://purl.uniprot.org/uniprot/A0A7N5P5K6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP12 family.|||Mitochondrion http://togogenome.org/gene/9646:VTA1 ^@ http://purl.uniprot.org/uniprot/D2GUS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTA1 family.|||Cytoplasm|||Endosome membrane|||Membrane http://togogenome.org/gene/9646:TRAPPC5 ^@ http://purl.uniprot.org/uniprot/D2HI87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||cis-Golgi network http://togogenome.org/gene/9646:DAZL ^@ http://purl.uniprot.org/uniprot/A0A7N5K1Y5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:DCTN5 ^@ http://purl.uniprot.org/uniprot/A0A7N5KKG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.|||cytoskeleton http://togogenome.org/gene/9646:FAM171A1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KIM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM171 family.|||Membrane http://togogenome.org/gene/9646:NPPA ^@ http://purl.uniprot.org/uniprot/G1LTH0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the natriuretic peptide family.|||Cell projection|||Homodimer; disulfide-linked antiparallel dimer.|||Hormone produced in the kidneys that appears to be important for maintaining cardio-renal homeostasis. Mediates vasodilation, natriuresis and diuresis primarily in the renal system, in order to maintain the extracellular fluid volume and control the fluid-electrolyte balance. Specifically binds and stimulates cGMP production by renal transmembrane receptors, likely NPR1. Urodilatin not ANP, may be the natriuretic peptide responsible for the regulation of sodium and water homeostasis in the kidney.|||May have a role in cardio-renal homeostasis through regulation of diuresis and inhibiting aldosterone synthesis. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase. May have a role in potassium excretion but not sodium excretion (natriuresis). Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption.|||May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips.|||May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips.|||May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.|||May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, and vasodilation. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase. However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis. Appears to bind to specific receptors that are distinct from the receptors bound by the atrial natriuretic and long-acting natriuretic peptides. Possibly functions in protein excretion in urine by maintaining the integrity of the proximal tubules and enhancing protein excretion by decreasing proximal tubular protein reabsorption.|||May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, vasodilation, and inhibiting aldosterone synthesis. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase (By similarity). However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report, in vivo it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis (By similarity). Appears to bind to specific receptors that are distinct from the receptors bound by atrial natriuretic peptide and vessel dilator. Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption.|||May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips.|||Secreted http://togogenome.org/gene/9646:IGFBP4 ^@ http://purl.uniprot.org/uniprot/D2HR23 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Binds IGF2 more than IGF1.|||IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9646:LCN2 ^@ http://purl.uniprot.org/uniprot/G1M9R7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/9646:NDUFS2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JDT2 ^@ Similarity ^@ Belongs to the complex I 49 kDa subunit family. http://togogenome.org/gene/9646:PLA2G12A ^@ http://purl.uniprot.org/uniprot/D2I2D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Secreted http://togogenome.org/gene/9646:LOC100476410 ^@ http://purl.uniprot.org/uniprot/G1M598 ^@ Similarity ^@ Belongs to the GST superfamily. Theta family. http://togogenome.org/gene/9646:NUP50 ^@ http://purl.uniprot.org/uniprot/G1LR55 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/9646:OSGEPL1 ^@ http://purl.uniprot.org/uniprot/G1M0Q0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 divalent metal cation per subunit.|||Mitochondrion|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. http://togogenome.org/gene/9646:VSIG1 ^@ http://purl.uniprot.org/uniprot/G1L803 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:SPC24 ^@ http://purl.uniprot.org/uniprot/G1LWB9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the SPC24 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/9646:FAM187A ^@ http://purl.uniprot.org/uniprot/G1MNN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM187 family.|||Membrane http://togogenome.org/gene/9646:YEATS4 ^@ http://purl.uniprot.org/uniprot/A0A7N5J9P1|||http://purl.uniprot.org/uniprot/G1LZE9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:SLC6A6 ^@ http://purl.uniprot.org/uniprot/A0A7N5JZA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:MTMR2 ^@ http://purl.uniprot.org/uniprot/G1LN07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/9646:HEATR1 ^@ http://purl.uniprot.org/uniprot/D2I0E9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HEATR1/UTP10 family.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/9646:GDPD5 ^@ http://purl.uniprot.org/uniprot/D2H1D1|||http://purl.uniprot.org/uniprot/G1MF72 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9646:ZIC3 ^@ http://purl.uniprot.org/uniprot/D2HD88 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/9646:CLRN1 ^@ http://purl.uniprot.org/uniprot/D2H3Z4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/9646:CCN4 ^@ http://purl.uniprot.org/uniprot/A0A7N5K7E9 ^@ Caution|||Similarity ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:KDM3A ^@ http://purl.uniprot.org/uniprot/G1LTS0 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the JHDM2 histone demethylase family.|||Binds 1 Fe(2+) ion per subunit.|||Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.|||Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.|||Nucleus|||The JmjC domain and the C6-type zinc-finger are required for the demethylation activity. http://togogenome.org/gene/9646:LOC100484357 ^@ http://purl.uniprot.org/uniprot/A0A7N5P8J2|||http://purl.uniprot.org/uniprot/G1LJW6 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily. http://togogenome.org/gene/9646:LOC100469028 ^@ http://purl.uniprot.org/uniprot/G1MJL6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:HSD3B7 ^@ http://purl.uniprot.org/uniprot/G1LLV7 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9646:AZGP1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JYI2 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9646:GRM1 ^@ http://purl.uniprot.org/uniprot/G1LHF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:SLC45A2 ^@ http://purl.uniprot.org/uniprot/D2HC23 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:CRCP ^@ http://purl.uniprot.org/uniprot/A0A7N5KMX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC9 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/9646:TBK1 ^@ http://purl.uniprot.org/uniprot/A0A7N5J866 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:TFIP11 ^@ http://purl.uniprot.org/uniprot/D2HKD8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFP11/STIP family.|||Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.|||Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.|||Nucleus http://togogenome.org/gene/9646:CLDN5 ^@ http://purl.uniprot.org/uniprot/D2HEY1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9646:KCNB1 ^@ http://purl.uniprot.org/uniprot/D2GVP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.|||Lateral cell membrane|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synaptic cell membrane|||axon|||dendrite|||sarcolemma|||synaptosome http://togogenome.org/gene/9646:MED22 ^@ http://purl.uniprot.org/uniprot/G1LZ20 ^@ Function|||Subcellular Location Annotation ^@ Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/9646:ARMC1 ^@ http://purl.uniprot.org/uniprot/D2H415 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9646:PSMD13 ^@ http://purl.uniprot.org/uniprot/D2I616 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S11 family.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. http://togogenome.org/gene/9646:GFOD2 ^@ http://purl.uniprot.org/uniprot/D2H9F4 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. http://togogenome.org/gene/9646:DEDD2 ^@ http://purl.uniprot.org/uniprot/D2HNG8 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9646:HVCN1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JFA7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the hydrogen channel family.|||Homodimer.|||Membrane http://togogenome.org/gene/9646:PAPSS1 ^@ http://purl.uniprot.org/uniprot/G1L586 ^@ Similarity ^@ In the C-terminal section; belongs to the sulfate adenylyltransferase family.|||In the N-terminal section; belongs to the APS kinase family. http://togogenome.org/gene/9646:FZD3 ^@ http://purl.uniprot.org/uniprot/D2HAJ0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:EMC8 ^@ http://purl.uniprot.org/uniprot/D2GWN5 ^@ Similarity ^@ Belongs to the EMC8/EMC9 family. http://togogenome.org/gene/9646:PRL ^@ http://purl.uniprot.org/uniprot/Q8HXS1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the somatotropin/prolactin family.|||Interacts with PRLR.|||Prolactin acts primarily on the mammary gland by promoting lactation.|||Secreted http://togogenome.org/gene/9646:SURF6 ^@ http://purl.uniprot.org/uniprot/G1LZ28 ^@ Similarity ^@ Belongs to the SURF6 family. http://togogenome.org/gene/9646:VWC2L ^@ http://purl.uniprot.org/uniprot/G1LAX2 ^@ Subcellular Location Annotation ^@ Synapse http://togogenome.org/gene/9646:MYO5C ^@ http://purl.uniprot.org/uniprot/G1LKY6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9646:RPL21 ^@ http://purl.uniprot.org/uniprot/F2X260 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/9646:KIF15 ^@ http://purl.uniprot.org/uniprot/G1M062 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-12 subfamily.|||spindle http://togogenome.org/gene/9646:ELMO3 ^@ http://purl.uniprot.org/uniprot/G1MG03 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. http://togogenome.org/gene/9646:PSMB10 ^@ http://purl.uniprot.org/uniprot/G1MGU2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:LOC100476268 ^@ http://purl.uniprot.org/uniprot/G1MMP9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:ABCA9 ^@ http://purl.uniprot.org/uniprot/D2HSX8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:LOC100468610 ^@ http://purl.uniprot.org/uniprot/D2HNJ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:CMC4 ^@ http://purl.uniprot.org/uniprot/G1LZR9 ^@ Similarity ^@ Belongs to the CMC4 family. http://togogenome.org/gene/9646:GPRC6A ^@ http://purl.uniprot.org/uniprot/A0A7N5P2X9|||http://purl.uniprot.org/uniprot/D2HNW5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9646:MSR1 ^@ http://purl.uniprot.org/uniprot/D2I0F6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:APEX1 ^@ http://purl.uniprot.org/uniprot/D2I2U8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Cytoplasm|||Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.|||Mitochondrion|||Nucleus|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/9646:CEP55 ^@ http://purl.uniprot.org/uniprot/D2H3D1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:CD151 ^@ http://purl.uniprot.org/uniprot/D2I6I5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9646:LASP1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KS11|||http://purl.uniprot.org/uniprot/D2H536 ^@ Function|||Subcellular Location Annotation ^@ Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.|||cell cortex|||cytoskeleton http://togogenome.org/gene/9646:UBE2E1 ^@ http://purl.uniprot.org/uniprot/D2HKU5|||http://purl.uniprot.org/uniprot/G1L9Y1 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9646:LOC100471390 ^@ http://purl.uniprot.org/uniprot/D2HUM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/9646:IL18 ^@ http://purl.uniprot.org/uniprot/T2C4C0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-1 family.|||Cytoplasm|||Forms a ternary complex with ligand-binding receptor subunit IL18R1 and signaling receptor subunit IL18RAP at the plasma membrane. Mature IL18 first binds to IL18R1 forming a low affinity binary complex, which then interacts with IL18RAP to form a high affinity ternary complex that signals inside the cell. Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion.|||Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.|||Secreted http://togogenome.org/gene/9646:NDUFB10 ^@ http://purl.uniprot.org/uniprot/D2HE03 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.|||Belongs to the complex I NDUFB10 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:UBE2T ^@ http://purl.uniprot.org/uniprot/G1LZJ5 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9646:POLA1 ^@ http://purl.uniprot.org/uniprot/G1M8F8 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/9646:LOC100464625 ^@ http://purl.uniprot.org/uniprot/G1LEG0 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/9646:ATP6V0E1 ^@ http://purl.uniprot.org/uniprot/D2H5F3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase e1/e2 subunit family.|||Membrane http://togogenome.org/gene/9646:GNGT2 ^@ http://purl.uniprot.org/uniprot/D2H579 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9646:TSPAN3 ^@ http://purl.uniprot.org/uniprot/G1LT39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9646:HOXC6 ^@ http://purl.uniprot.org/uniprot/D2HM46 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:UNC119 ^@ http://purl.uniprot.org/uniprot/A0A7N5JE75 ^@ Similarity ^@ Belongs to the PDE6D/unc-119 family. http://togogenome.org/gene/9646:LOC100468044 ^@ http://purl.uniprot.org/uniprot/A0A7N5P8I9 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9646:FSHB ^@ http://purl.uniprot.org/uniprot/D2HUC2|||http://purl.uniprot.org/uniprot/Q8WN19 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit beta family.|||Heterodimer. The active follitropin is a heterodimer composed of an alpha chain/CGA shared with other hormones and a unique beta chain/FSHB shown here.|||Secreted|||Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. http://togogenome.org/gene/9646:SLC30A2 ^@ http://purl.uniprot.org/uniprot/G1LV00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9646:LOC109489291 ^@ http://purl.uniprot.org/uniprot/D2H5W7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/9646:RAD21 ^@ http://purl.uniprot.org/uniprot/D2HZV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad21 family.|||Nucleus http://togogenome.org/gene/9646:USP39 ^@ http://purl.uniprot.org/uniprot/G1L6A4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:LOC100470304 ^@ http://purl.uniprot.org/uniprot/A0A7N5KL41 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/9646:LOC109488460 ^@ http://purl.uniprot.org/uniprot/D2I4Z6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:KCTD20 ^@ http://purl.uniprot.org/uniprot/D2GYV4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:LOC100472672 ^@ http://purl.uniprot.org/uniprot/G1LD28 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/9646:ZNF277 ^@ http://purl.uniprot.org/uniprot/G1LGG7 ^@ Similarity ^@ Belongs to the ZNF277 family. http://togogenome.org/gene/9646:ASPDH ^@ http://purl.uniprot.org/uniprot/G1M2T6 ^@ Similarity ^@ Belongs to the L-aspartate dehydrogenase family. http://togogenome.org/gene/9646:GRM8 ^@ http://purl.uniprot.org/uniprot/G1LD81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:PDE6D ^@ http://purl.uniprot.org/uniprot/G1MCW4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PDE6D/unc-119 family.|||Cytoplasmic vesicle membrane|||Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains and two inhibitory chains; has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane.|||Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.|||cilium basal body|||cytosol http://togogenome.org/gene/9646:LOC100473113 ^@ http://purl.uniprot.org/uniprot/G1M620 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9646:LSM5 ^@ http://purl.uniprot.org/uniprot/A0A7N5K1Z4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. http://togogenome.org/gene/9646:TLR5 ^@ http://purl.uniprot.org/uniprot/D2HJD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9646:DYNLL2 ^@ http://purl.uniprot.org/uniprot/D2H256 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/9646:TCTN3 ^@ http://purl.uniprot.org/uniprot/G1MBW5 ^@ Similarity|||Subunit ^@ Belongs to the tectonic family.|||Part of the tectonic-like complex (also named B9 complex). http://togogenome.org/gene/9646:CGA ^@ http://purl.uniprot.org/uniprot/G1LYF7|||http://purl.uniprot.org/uniprot/Q8WN20 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit alpha family.|||Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.|||Secreted|||Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. http://togogenome.org/gene/9646:ATF7IP2 ^@ http://purl.uniprot.org/uniprot/G1M8L9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCAF family.|||Nucleus http://togogenome.org/gene/9646:NFKB1 ^@ http://purl.uniprot.org/uniprot/G1LQS1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9646:LOC100473570 ^@ http://purl.uniprot.org/uniprot/A0A7N5K5K2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/9646:LOC100481277 ^@ http://purl.uniprot.org/uniprot/G1MLF8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:TMEM256 ^@ http://purl.uniprot.org/uniprot/G1ME39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM256 family.|||Membrane http://togogenome.org/gene/9646:SNRPG ^@ http://purl.uniprot.org/uniprot/G1MC08 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus|||Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.|||cytosol http://togogenome.org/gene/9646:LOC100482795 ^@ http://purl.uniprot.org/uniprot/G1MN63 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL43 family. http://togogenome.org/gene/9646:MUS81 ^@ http://purl.uniprot.org/uniprot/G1MG23 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XPF family.|||Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).|||Interacts with EME1.|||Nucleus http://togogenome.org/gene/9646:ADCY3 ^@ http://purl.uniprot.org/uniprot/D2GXP9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Membrane http://togogenome.org/gene/9646:PPP1R3B ^@ http://purl.uniprot.org/uniprot/D2I1W2|||http://purl.uniprot.org/uniprot/G1MNS0 ^@ Subunit ^@ Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity. http://togogenome.org/gene/9646:HINT1 ^@ http://purl.uniprot.org/uniprot/D2HVN8 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/9646:ANXA13 ^@ http://purl.uniprot.org/uniprot/A0A7N5KLK1|||http://purl.uniprot.org/uniprot/G1LXJ9 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9646:TAT ^@ http://purl.uniprot.org/uniprot/D2HFW4 ^@ Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer. http://togogenome.org/gene/9646:SEH1L ^@ http://purl.uniprot.org/uniprot/D2HKN7|||http://purl.uniprot.org/uniprot/G1MHC8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.|||Lysosome membrane|||kinetochore http://togogenome.org/gene/9646:SPOP ^@ http://purl.uniprot.org/uniprot/D2HMY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tdpoz family.|||Nucleus speckle http://togogenome.org/gene/9646:MRPL35 ^@ http://purl.uniprot.org/uniprot/A0A7N5JHG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bL35 family.|||Mitochondrion http://togogenome.org/gene/9646:OCIAD1 ^@ http://purl.uniprot.org/uniprot/G1LNP7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OCIAD1 family.|||Endosome|||Interacts with STAT3.|||Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.|||The OCIA domain is necessary and sufficient for endosomal localization. http://togogenome.org/gene/9646:LCK ^@ http://purl.uniprot.org/uniprot/G1LMD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/9646:MAK16 ^@ http://purl.uniprot.org/uniprot/G1L801 ^@ Similarity ^@ Belongs to the MAK16 family. http://togogenome.org/gene/9646:PIWIL1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JP18|||http://purl.uniprot.org/uniprot/D2HWM8 ^@ Similarity ^@ Belongs to the argonaute family. http://togogenome.org/gene/9646:SOSTDC1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KQG4 ^@ Caution|||Similarity ^@ Belongs to the sclerostin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:LIPM ^@ http://purl.uniprot.org/uniprot/G1L1Y9 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9646:LOC100475926 ^@ http://purl.uniprot.org/uniprot/D2I565 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:RRS1 ^@ http://purl.uniprot.org/uniprot/D2H419 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRS1 family.|||Involved in ribosomal large subunit assembly.|||Nucleus http://togogenome.org/gene/9646:ARF6 ^@ http://purl.uniprot.org/uniprot/D2HIE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||Cell membrane|||Cleavage furrow|||Endosome membrane|||Midbody ring|||Recycling endosome membrane|||filopodium membrane|||ruffle http://togogenome.org/gene/9646:ASCC3 ^@ http://purl.uniprot.org/uniprot/D2HIC5 ^@ Similarity ^@ Belongs to the helicase family. http://togogenome.org/gene/9646:LOC100465427 ^@ http://purl.uniprot.org/uniprot/A0A7N5JNU6 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9646:ACKR1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KAN7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.|||Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.|||Early endosome|||Membrane|||Recycling endosome http://togogenome.org/gene/9646:PDCD4 ^@ http://purl.uniprot.org/uniprot/A0A7N5JG17 ^@ Similarity ^@ Belongs to the PDCD4 family. http://togogenome.org/gene/9646:PTGER4 ^@ http://purl.uniprot.org/uniprot/D2HJX9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with FEM1A.|||Membrane|||Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. http://togogenome.org/gene/9646:GSDMA ^@ http://purl.uniprot.org/uniprot/A0A7N5K1R2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gasdermin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:MTIF2 ^@ http://purl.uniprot.org/uniprot/D2GY80 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/9646:HSD17B3 ^@ http://purl.uniprot.org/uniprot/A0A7N5K4E2|||http://purl.uniprot.org/uniprot/A0A7N5KLQ4|||http://purl.uniprot.org/uniprot/A0A7N5P9D1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9646:ST6GALNAC3 ^@ http://purl.uniprot.org/uniprot/G1LAB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9646:ADH5 ^@ http://purl.uniprot.org/uniprot/G1M5T4 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. http://togogenome.org/gene/9646:PAX5 ^@ http://purl.uniprot.org/uniprot/G1LU97 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:GNGT1 ^@ http://purl.uniprot.org/uniprot/D2H8V1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9646:CALR3 ^@ http://purl.uniprot.org/uniprot/D2GUZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calreticulin family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9646:ELOVL6 ^@ http://purl.uniprot.org/uniprot/D2H706 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Membrane http://togogenome.org/gene/9646:RPA2 ^@ http://purl.uniprot.org/uniprot/G1LXA5 ^@ Similarity ^@ Belongs to the replication factor A protein 2 family. http://togogenome.org/gene/9646:LAMTOR5 ^@ http://purl.uniprot.org/uniprot/A0A7N5K0Y9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR5 family.|||Lysosome http://togogenome.org/gene/9646:LOC100472383 ^@ http://purl.uniprot.org/uniprot/D2HT44 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9646:MYOD1 ^@ http://purl.uniprot.org/uniprot/D2I0V4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.|||Nucleus http://togogenome.org/gene/9646:PSME3IP1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JF08 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:TARDBP ^@ http://purl.uniprot.org/uniprot/D2HKA5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:PRPH2 ^@ http://purl.uniprot.org/uniprot/D2GZE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRPH2/ROM1 family.|||Membrane http://togogenome.org/gene/9646:ST6GALNAC4 ^@ http://purl.uniprot.org/uniprot/G1M9I3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9646:CAPN2 ^@ http://purl.uniprot.org/uniprot/A0A7N5KEN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C2 family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9646:RPS29 ^@ http://purl.uniprot.org/uniprot/F2X227 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Component of the 40S small ribosomal subunit. http://togogenome.org/gene/9646:RNGTT ^@ http://purl.uniprot.org/uniprot/G1L0L8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.|||In the C-terminal section; belongs to the eukaryotic GTase family.|||In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.|||Nucleus http://togogenome.org/gene/9646:SLC25A3 ^@ http://purl.uniprot.org/uniprot/A0A7N5KC34|||http://purl.uniprot.org/uniprot/D2HE44 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Interacts with PPIF; the interaction is impaired by CsA.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9646:PSMC1 ^@ http://purl.uniprot.org/uniprot/A0A7N5J9R3 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9646:LOC100480394 ^@ http://purl.uniprot.org/uniprot/A0A7N5JJE8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:EXTL1 ^@ http://purl.uniprot.org/uniprot/D2GWF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:ALOX5AP ^@ http://purl.uniprot.org/uniprot/A0A7N5JHE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:TAF8 ^@ http://purl.uniprot.org/uniprot/G1M2Y5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF8 family.|||Nucleus http://togogenome.org/gene/9646:LOC100463816 ^@ http://purl.uniprot.org/uniprot/G1LHT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9646:HAPLN1 ^@ http://purl.uniprot.org/uniprot/G1LLU8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9646:PROX1 ^@ http://purl.uniprot.org/uniprot/G1MBC1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:LCAT ^@ http://purl.uniprot.org/uniprot/A0A7N5JCH2|||http://purl.uniprot.org/uniprot/A0A7N5P0Z6 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9646:NOP58 ^@ http://purl.uniprot.org/uniprot/G1M3K5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP5/NOP56 family.|||nucleolus http://togogenome.org/gene/9646:TJP2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JM83|||http://purl.uniprot.org/uniprot/A0A7N5KNU0|||http://purl.uniprot.org/uniprot/G1LK83 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9646:SLC33A1 ^@ http://purl.uniprot.org/uniprot/D2HT98 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:PGAP3 ^@ http://purl.uniprot.org/uniprot/D2I2F9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PGAP3 family.|||Golgi apparatus membrane|||Involved in the lipid remodeling steps of GPI-anchor maturation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:LOC100470585 ^@ http://purl.uniprot.org/uniprot/A0A7N5P8B3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Belongs to the calycin superfamily. Lipocalin family.|||May play a role in lipid transport protein in Schwann cells. May bind cholesterol.|||Monomer. http://togogenome.org/gene/9646:TRMT1 ^@ http://purl.uniprot.org/uniprot/G1M1S7 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. http://togogenome.org/gene/9646:SVOPL ^@ http://purl.uniprot.org/uniprot/G1MI25 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:KATNAL2 ^@ http://purl.uniprot.org/uniprot/G1M2A8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.|||Cytoplasm|||Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/9646:RRP1 ^@ http://purl.uniprot.org/uniprot/G1LYA4 ^@ Similarity ^@ Belongs to the RRP1 family. http://togogenome.org/gene/9646:TAX1BP3 ^@ http://purl.uniprot.org/uniprot/G1LRM9 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Cytoplasm|||May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.|||Nucleus http://togogenome.org/gene/9646:DAP3 ^@ http://purl.uniprot.org/uniprot/G1KZJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS29 family.|||Mitochondrion http://togogenome.org/gene/9646:PHOSPHO2 ^@ http://purl.uniprot.org/uniprot/D2H4C7 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. PHOSPHO family. http://togogenome.org/gene/9646:EID1 ^@ http://purl.uniprot.org/uniprot/G1MLU6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:BORCS8 ^@ http://purl.uniprot.org/uniprot/G1LYY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS8 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9646:SLC17A4 ^@ http://purl.uniprot.org/uniprot/G1LTU4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:ATP2A2 ^@ http://purl.uniprot.org/uniprot/G1M646 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/9646:ZW10 ^@ http://purl.uniprot.org/uniprot/D2HZX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZW10 family.|||kinetochore http://togogenome.org/gene/9646:ZDHHC4 ^@ http://purl.uniprot.org/uniprot/G1LJG0 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9646:SLC22A5 ^@ http://purl.uniprot.org/uniprot/D2GVH3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Basal cell membrane|||Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.|||Interacts with PDZK1. http://togogenome.org/gene/9646:TOMM40L ^@ http://purl.uniprot.org/uniprot/D2I0S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom40 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9646:LOC100483805 ^@ http://purl.uniprot.org/uniprot/D2I6C4 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:UCN3 ^@ http://purl.uniprot.org/uniprot/D2HEB0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Binds with high affinity to CRF receptors 2-alpha and 2-beta.|||Secreted|||Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. http://togogenome.org/gene/9646:CLK4 ^@ http://purl.uniprot.org/uniprot/D2HGD2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9646:LOC100476603 ^@ http://purl.uniprot.org/uniprot/G1MPD2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:CHRNA1 ^@ http://purl.uniprot.org/uniprot/G1M0T4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9646:USP48 ^@ http://purl.uniprot.org/uniprot/A0A7N5KCA6|||http://purl.uniprot.org/uniprot/G1M752 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Nucleus http://togogenome.org/gene/9646:TMEM150C ^@ http://purl.uniprot.org/uniprot/D2GUF3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:RSPO2 ^@ http://purl.uniprot.org/uniprot/G1M298 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/9646:LOC100481084 ^@ http://purl.uniprot.org/uniprot/A0A7N5JNH5|||http://purl.uniprot.org/uniprot/D2H835|||http://purl.uniprot.org/uniprot/G1MCM1|||http://purl.uniprot.org/uniprot/G1MCM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9646:ATP9B ^@ http://purl.uniprot.org/uniprot/G1LUR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9646:LANCL1 ^@ http://purl.uniprot.org/uniprot/G1LEM2 ^@ Similarity ^@ Belongs to the LanC-like protein family. http://togogenome.org/gene/9646:MYO1A ^@ http://purl.uniprot.org/uniprot/D2H372 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9646:HSF2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JIB3|||http://purl.uniprot.org/uniprot/D2HCP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/9646:CTSE ^@ http://purl.uniprot.org/uniprot/G1M264 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/9646:NMNAT1 ^@ http://purl.uniprot.org/uniprot/D2HA35 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/9646:IL1RAP ^@ http://purl.uniprot.org/uniprot/A0A7N5JIH0 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9646:AWAT1 ^@ http://purl.uniprot.org/uniprot/G1LRB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9646:NUP62 ^@ http://purl.uniprot.org/uniprot/D2H7U0 ^@ Similarity ^@ Belongs to the nucleoporin NSP1/NUP62 family. http://togogenome.org/gene/9646:SEC22B ^@ http://purl.uniprot.org/uniprot/G1LZ42 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Melanosome|||Membrane|||SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/9646:MAPK1IP1L ^@ http://purl.uniprot.org/uniprot/G1LKH2 ^@ Similarity ^@ Belongs to the MISS family. http://togogenome.org/gene/9646:FGF10 ^@ http://purl.uniprot.org/uniprot/D2HSJ5 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9646:AMIGO2 ^@ http://purl.uniprot.org/uniprot/D2HJ35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. AMIGO family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:IMMP1L ^@ http://purl.uniprot.org/uniprot/G1LJZ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26 family.|||Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.|||Heterodimer of 2 subunits, IMMPL1 and IMMPL2.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:PREPL ^@ http://purl.uniprot.org/uniprot/D2GU97 ^@ Similarity ^@ Belongs to the peptidase S9A family. http://togogenome.org/gene/9646:CA8 ^@ http://purl.uniprot.org/uniprot/A0A7N5P2J9|||http://purl.uniprot.org/uniprot/G1LGX2 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9646:B9D1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KF30 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/9646:BABAM1 ^@ http://purl.uniprot.org/uniprot/G1LV77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BABAM1 family.|||Nucleus http://togogenome.org/gene/9646:POLR1C ^@ http://purl.uniprot.org/uniprot/D2GZB5 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/9646:DRGX ^@ http://purl.uniprot.org/uniprot/G1LV28 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:PSMA8 ^@ http://purl.uniprot.org/uniprot/G1M6I4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9646:LOC100468607 ^@ http://purl.uniprot.org/uniprot/G1LEV6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9646:GPR137 ^@ http://purl.uniprot.org/uniprot/G1MI14 ^@ Subcellular Location Annotation ^@ Lysosome membrane|||Membrane http://togogenome.org/gene/9646:INTS11 ^@ http://purl.uniprot.org/uniprot/G1M5A3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.|||Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.|||Nucleus http://togogenome.org/gene/9646:S100PBP ^@ http://purl.uniprot.org/uniprot/G1LLP2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:NDUFA12 ^@ http://purl.uniprot.org/uniprot/D2HBK3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA12 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:SLCO1A2 ^@ http://purl.uniprot.org/uniprot/G1L278 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:MRPL53 ^@ http://purl.uniprot.org/uniprot/D2HH60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL53 family.|||Mitochondrion http://togogenome.org/gene/9646:MAP2K6 ^@ http://purl.uniprot.org/uniprot/G1LLJ8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9646:CBLB ^@ http://purl.uniprot.org/uniprot/A0A7N5P587|||http://purl.uniprot.org/uniprot/D2H3B0 ^@ Domain|||Function ^@ E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.|||The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain. http://togogenome.org/gene/9646:TMX2 ^@ http://purl.uniprot.org/uniprot/G1M7S9 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain.|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9646:CYRIB ^@ http://purl.uniprot.org/uniprot/A0A7N5KPV4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CYRI family.|||Interacts with RAC1 (GTP-bound form preferentially).|||Membrane http://togogenome.org/gene/9646:PEX16 ^@ http://purl.uniprot.org/uniprot/G1L1C6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-16 family.|||Peroxisome membrane http://togogenome.org/gene/9646:PMP22 ^@ http://purl.uniprot.org/uniprot/A0A7N5KNY5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Might be involved in growth regulation, and in myelinization in the peripheral nervous system. http://togogenome.org/gene/9646:ZBTB8OS ^@ http://purl.uniprot.org/uniprot/A0A7N5KLM4|||http://purl.uniprot.org/uniprot/D2HI52 ^@ Similarity|||Subunit ^@ Belongs to the archease family.|||Component of the tRNA-splicing ligase complex. http://togogenome.org/gene/9646:C3H5orf63 ^@ http://purl.uniprot.org/uniprot/A0A7N5JQH7 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/9646:LOC100469388 ^@ http://purl.uniprot.org/uniprot/D2I4W4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:HDAC9 ^@ http://purl.uniprot.org/uniprot/A0A7N5P1Y5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD type 2 subfamily.|||Nucleus|||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. http://togogenome.org/gene/9646:LCTL ^@ http://purl.uniprot.org/uniprot/D2GYU2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/9646:LPAR1 ^@ http://purl.uniprot.org/uniprot/G1MI20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cell surface|||Endosome|||Membrane http://togogenome.org/gene/9646:LBR ^@ http://purl.uniprot.org/uniprot/D2HYY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/9646:LTA4H ^@ http://purl.uniprot.org/uniprot/D2HBJ3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit.|||Cytoplasm http://togogenome.org/gene/9646:MRPS15 ^@ http://purl.uniprot.org/uniprot/G1L3T6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/9646:DIS3L ^@ http://purl.uniprot.org/uniprot/A0A7N5K3I6 ^@ Similarity ^@ Belongs to the RNR ribonuclease family. http://togogenome.org/gene/9646:PRPS1 ^@ http://purl.uniprot.org/uniprot/D2HJV9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family.|||Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.|||Homodimer. The active form is probably a hexamer composed of 3 homodimers. http://togogenome.org/gene/9646:NPRL2 ^@ http://purl.uniprot.org/uniprot/D2HES3 ^@ Similarity ^@ Belongs to the NPR2 family. http://togogenome.org/gene/9646:KCNS2 ^@ http://purl.uniprot.org/uniprot/G1MN46 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:MTTP ^@ http://purl.uniprot.org/uniprot/G1L2K6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:NCOA2 ^@ http://purl.uniprot.org/uniprot/G1LI96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRC/p160 nuclear receptor coactivator family.|||Nucleus http://togogenome.org/gene/9646:LOC100464456 ^@ http://purl.uniprot.org/uniprot/G1M220 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9646:TRIAP1 ^@ http://purl.uniprot.org/uniprot/G1M3T6 ^@ Similarity ^@ Belongs to the TRIAP1/MDM35 family. http://togogenome.org/gene/9646:SLCO5A1 ^@ http://purl.uniprot.org/uniprot/D2H9L3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:MTMR6 ^@ http://purl.uniprot.org/uniprot/G1M6K7 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9646:MTFMT ^@ http://purl.uniprot.org/uniprot/G1L7P1 ^@ Similarity ^@ Belongs to the Fmt family. http://togogenome.org/gene/9646:CAPZA3 ^@ http://purl.uniprot.org/uniprot/D2HI28 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/9646:P4HA1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JLM7|||http://purl.uniprot.org/uniprot/G1MF58 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9646:CHMP2A ^@ http://purl.uniprot.org/uniprot/G1LLY3 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9646:SPINK4 ^@ http://purl.uniprot.org/uniprot/D2HUA7 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9646:LOC100466991 ^@ http://purl.uniprot.org/uniprot/A0A7N5KAP6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCRB/QCR7 family.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:PHLDA3 ^@ http://purl.uniprot.org/uniprot/G1MNM5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:NTAQ1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KLL7|||http://purl.uniprot.org/uniprot/G1LXB1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NTAQ1 family.|||Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.|||Monomer. http://togogenome.org/gene/9646:PRKAR1B ^@ http://purl.uniprot.org/uniprot/D2I2Z1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:LOC100472558 ^@ http://purl.uniprot.org/uniprot/G1MKR6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:GRHL3 ^@ http://purl.uniprot.org/uniprot/G1LTX3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:SLC25A51 ^@ http://purl.uniprot.org/uniprot/D2H0I0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9646:EFHC1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JCS1 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9646:TAAR5 ^@ http://purl.uniprot.org/uniprot/D2HL29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9646:GLOD4 ^@ http://purl.uniprot.org/uniprot/G1LNZ3 ^@ Similarity ^@ Belongs to the glyoxalase I family. http://togogenome.org/gene/9646:ARMCX3 ^@ http://purl.uniprot.org/uniprot/D2I2N2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eutherian X-chromosome-specific Armcx family.|||Membrane http://togogenome.org/gene/9646:EBAG9 ^@ http://purl.uniprot.org/uniprot/G1LHY8 ^@ Function|||Subcellular Location Annotation ^@ Golgi apparatus membrane|||May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. http://togogenome.org/gene/9646:SLC35F6 ^@ http://purl.uniprot.org/uniprot/G1L5T6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SLC35F solute transporter family.|||Interacts with SLC25A5.|||May play a role as a nucleotide-sugar transporter.|||Membrane|||Mitochondrion http://togogenome.org/gene/9646:NDUFAF3 ^@ http://purl.uniprot.org/uniprot/D2HEW2 ^@ Function|||Subcellular Location Annotation ^@ Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).|||Membrane|||Mitochondrion inner membrane|||Nucleus http://togogenome.org/gene/9646:TMEM184A ^@ http://purl.uniprot.org/uniprot/D2HNU1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:FHL5 ^@ http://purl.uniprot.org/uniprot/D2HXV6 ^@ Function|||Subcellular Location Annotation ^@ May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.|||Nucleus http://togogenome.org/gene/9646:LOC100474856 ^@ http://purl.uniprot.org/uniprot/A0A7N5K062 ^@ Similarity ^@ Belongs to the intercrine beta (chemokine CC) family. http://togogenome.org/gene/9646:ZNF174 ^@ http://purl.uniprot.org/uniprot/G1LVR7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:LOC100468460 ^@ http://purl.uniprot.org/uniprot/D2I5M7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane http://togogenome.org/gene/9646:MED29 ^@ http://purl.uniprot.org/uniprot/G1LPH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 29 family.|||Nucleus http://togogenome.org/gene/9646:VAC14 ^@ http://purl.uniprot.org/uniprot/D2HFV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VAC14 family.|||Endosome membrane|||Microsome membrane http://togogenome.org/gene/9646:GSG1L2 ^@ http://purl.uniprot.org/uniprot/G1M092 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSG1 family.|||Membrane http://togogenome.org/gene/9646:LOC100483962 ^@ http://purl.uniprot.org/uniprot/A0A7N5JYF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9646:LOC100465141 ^@ http://purl.uniprot.org/uniprot/G1L9B0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTF2H2 family.|||Nucleus http://togogenome.org/gene/9646:PLPPR2 ^@ http://purl.uniprot.org/uniprot/G1LVU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9646:TSEN15 ^@ http://purl.uniprot.org/uniprot/A0A7N5K8S0 ^@ Similarity ^@ Belongs to the SEN15 family. http://togogenome.org/gene/9646:ACOX1 ^@ http://purl.uniprot.org/uniprot/A0A7N5P608|||http://purl.uniprot.org/uniprot/G1LTX1|||http://purl.uniprot.org/uniprot/G1LTX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/9646:NMBR ^@ http://purl.uniprot.org/uniprot/D2GUS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:LOC100475019 ^@ http://purl.uniprot.org/uniprot/G1MMR1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:GAS6 ^@ http://purl.uniprot.org/uniprot/G1LCY3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:AKR1D1 ^@ http://purl.uniprot.org/uniprot/G1MI75 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9646:CA2 ^@ http://purl.uniprot.org/uniprot/G1L761 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9646:EIF4EBP3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JQS8 ^@ Similarity ^@ Belongs to the eIF4E-binding protein family. http://togogenome.org/gene/9646:AP1S1 ^@ http://purl.uniprot.org/uniprot/G1L7G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||Membrane|||clathrin-coated pit http://togogenome.org/gene/9646:PLP2 ^@ http://purl.uniprot.org/uniprot/D2H7M2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:SEMA4A ^@ http://purl.uniprot.org/uniprot/G1M747 ^@ Similarity ^@ Belongs to the semaphorin family. http://togogenome.org/gene/9646:PAF1 ^@ http://purl.uniprot.org/uniprot/G1LPL2 ^@ Similarity ^@ Belongs to the PAF1 family. http://togogenome.org/gene/9646:RBP2 ^@ http://purl.uniprot.org/uniprot/D2I6R1 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9646:MED23 ^@ http://purl.uniprot.org/uniprot/A0A7N5JTE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 23 family.|||Nucleus http://togogenome.org/gene/9646:GOSR1 ^@ http://purl.uniprot.org/uniprot/G1LB09 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GOSR1 family.|||Component of several multiprotein Golgi SNARE complexes.|||Golgi apparatus membrane|||Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.|||Membrane http://togogenome.org/gene/9646:THNSL1 ^@ http://purl.uniprot.org/uniprot/D2I7J7 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/9646:TPRG1L ^@ http://purl.uniprot.org/uniprot/D2HC11 ^@ Similarity ^@ Belongs to the TPRG1 family. http://togogenome.org/gene/9646:CCNA1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KGS9 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin AB subfamily. http://togogenome.org/gene/9646:SLC25A17 ^@ http://purl.uniprot.org/uniprot/A0A7N5K0T6|||http://purl.uniprot.org/uniprot/G1M5K0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9646:C4H2orf49 ^@ http://purl.uniprot.org/uniprot/A0A7N5K3Z9|||http://purl.uniprot.org/uniprot/G1M3T1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ashwin family.|||Nucleus http://togogenome.org/gene/9646:PRKAR1A ^@ http://purl.uniprot.org/uniprot/D2HSY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:EFEMP1 ^@ http://purl.uniprot.org/uniprot/D2GY76 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:TEX261 ^@ http://purl.uniprot.org/uniprot/G1MBJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SVP26 family.|||Membrane http://togogenome.org/gene/9646:HOXC4 ^@ http://purl.uniprot.org/uniprot/D2HM48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9646:LAMP2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JZT9|||http://purl.uniprot.org/uniprot/G1L021 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9646:MSX2 ^@ http://purl.uniprot.org/uniprot/D2H5G1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:PIGK ^@ http://purl.uniprot.org/uniprot/G1LKX8 ^@ Similarity|||Subunit ^@ Belongs to the peptidase C13 family.|||Forms a complex with PIGT, PIGS, PIGU and GAA1. http://togogenome.org/gene/9646:GPR146 ^@ http://purl.uniprot.org/uniprot/G1MP48 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9646:ALKBH1 ^@ http://purl.uniprot.org/uniprot/D2HUS3 ^@ Cofactor ^@ Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/9646:TSR2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JV56 ^@ Function|||Similarity ^@ Belongs to the TSR2 family.|||May be involved in 20S pre-rRNA processing. http://togogenome.org/gene/9646:KNG1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JWY1 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/9646:PPP5C ^@ http://purl.uniprot.org/uniprot/D2HL56 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily. http://togogenome.org/gene/9646:MTMR10 ^@ http://purl.uniprot.org/uniprot/G1MAA1 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9646:MRPS24 ^@ http://purl.uniprot.org/uniprot/D2HNM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS3 family.|||Mitochondrion http://togogenome.org/gene/9646:CDR2L ^@ http://purl.uniprot.org/uniprot/A0A7N5K7G5 ^@ Similarity ^@ Belongs to the CDR2 family. http://togogenome.org/gene/9646:GABRA6 ^@ http://purl.uniprot.org/uniprot/D2GUJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9646:DDX28 ^@ http://purl.uniprot.org/uniprot/G1MM92 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9646:CCSER1 ^@ http://purl.uniprot.org/uniprot/G1M968 ^@ Similarity ^@ Belongs to the CCSER family. http://togogenome.org/gene/9646:LOC100465480 ^@ http://purl.uniprot.org/uniprot/A0A7N5J826 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Membrane http://togogenome.org/gene/9646:SFMBT1 ^@ http://purl.uniprot.org/uniprot/G1LN74 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:TAFA2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JQF8 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/9646:AMPD2 ^@ http://purl.uniprot.org/uniprot/A0A7N5KLQ8 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/9646:PPM1A ^@ http://purl.uniprot.org/uniprot/A0A7N5JUQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PP2C family.|||Membrane|||cytosol http://togogenome.org/gene/9646:MPZ ^@ http://purl.uniprot.org/uniprot/G1MA37 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the myelin P0 protein family.|||Cell membrane|||Homodimer and homotetramer.|||Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction.|||Membrane http://togogenome.org/gene/9646:INO80C ^@ http://purl.uniprot.org/uniprot/G1L0P4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:MFRP ^@ http://purl.uniprot.org/uniprot/D2GYA3 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:GALNT13 ^@ http://purl.uniprot.org/uniprot/G1LGB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:LOC100468691 ^@ http://purl.uniprot.org/uniprot/G1M9E3 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9646:LYG1 ^@ http://purl.uniprot.org/uniprot/G1M3X2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 23 family. http://togogenome.org/gene/9646:LOC100471205 ^@ http://purl.uniprot.org/uniprot/D2HLN1 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9646:PTPN22 ^@ http://purl.uniprot.org/uniprot/G1L9D3 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. http://togogenome.org/gene/9646:RPL30 ^@ http://purl.uniprot.org/uniprot/D3YBZ7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/9646:TENT5C ^@ http://purl.uniprot.org/uniprot/D2HQ27 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/9646:MTRF1 ^@ http://purl.uniprot.org/uniprot/D2H2S4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Mitochondrion http://togogenome.org/gene/9646:POLR2C ^@ http://purl.uniprot.org/uniprot/D2GTX3 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/9646:LDLRAD4 ^@ http://purl.uniprot.org/uniprot/A0A7N5KQH9|||http://purl.uniprot.org/uniprot/G1MH96 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMEPA1 family.|||Early endosome membrane|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:STXBP5 ^@ http://purl.uniprot.org/uniprot/A0A7N5JD04|||http://purl.uniprot.org/uniprot/A0A7N5JSX7|||http://purl.uniprot.org/uniprot/G1MCW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat L(2)GL family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9646:NEU2 ^@ http://purl.uniprot.org/uniprot/G1MD87 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/9646:ZMYND10 ^@ http://purl.uniprot.org/uniprot/D2HES4 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the ZMYND10 family.|||Dynein axonemal particle|||centriolar satellite http://togogenome.org/gene/9646:MGAT5B ^@ http://purl.uniprot.org/uniprot/A0A7N5P134 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 18 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:PDZK1IP1 ^@ http://purl.uniprot.org/uniprot/A0A7N5K0K0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:LOC100470998 ^@ http://purl.uniprot.org/uniprot/G1MDS2 ^@ Domain|||Subcellular Location Annotation ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding.|||cytosol http://togogenome.org/gene/9646:MLF1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JY32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MLF family.|||Cytoplasm http://togogenome.org/gene/9646:TMEM39A ^@ http://purl.uniprot.org/uniprot/G1LL27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM39 family.|||Membrane http://togogenome.org/gene/9646:SLC1A3 ^@ http://purl.uniprot.org/uniprot/D2HLY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9646:GABRA5 ^@ http://purl.uniprot.org/uniprot/D2HI26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9646:MYH9 ^@ http://purl.uniprot.org/uniprot/D2GZG2 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9646:ISL1 ^@ http://purl.uniprot.org/uniprot/G1LH63 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:SS18L2 ^@ http://purl.uniprot.org/uniprot/D2HSV4 ^@ Similarity ^@ Belongs to the SS18 family. http://togogenome.org/gene/9646:UBE2E2 ^@ http://purl.uniprot.org/uniprot/A0A7N5K1K9 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9646:NPPB ^@ http://purl.uniprot.org/uniprot/A0A7N5JXD8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the natriuretic peptide family.|||Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (By similarity). May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3.|||Secreted http://togogenome.org/gene/9646:COMP ^@ http://purl.uniprot.org/uniprot/D2GV41 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:LOC100469323 ^@ http://purl.uniprot.org/uniprot/D2H861 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9646:FAM3B ^@ http://purl.uniprot.org/uniprot/A0A7N5KR41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/9646:FOXL1 ^@ http://purl.uniprot.org/uniprot/D2GWM9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:LOC100480547 ^@ http://purl.uniprot.org/uniprot/D2I7M3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:TGM7 ^@ http://purl.uniprot.org/uniprot/G1MAE9 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9646:RASGRP4 ^@ http://purl.uniprot.org/uniprot/G1LUU4 ^@ Similarity ^@ Belongs to the RASGRP family. http://togogenome.org/gene/9646:GBF1 ^@ http://purl.uniprot.org/uniprot/D2GXW0 ^@ Subcellular Location Annotation ^@ Golgi apparatus http://togogenome.org/gene/9646:PIAS2 ^@ http://purl.uniprot.org/uniprot/A0A7N5KI91 ^@ Similarity ^@ Belongs to the PIAS family. http://togogenome.org/gene/9646:C16H11orf58 ^@ http://purl.uniprot.org/uniprot/G1L7X6 ^@ Similarity ^@ Belongs to the SMAP family. http://togogenome.org/gene/9646:IFI44L ^@ http://purl.uniprot.org/uniprot/D2HHV1 ^@ Similarity ^@ Belongs to the IFI44 family. http://togogenome.org/gene/9646:DDR1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KTC7|||http://purl.uniprot.org/uniprot/A0A7N5P9Y9|||http://purl.uniprot.org/uniprot/G1M3B9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:PPM1L ^@ http://purl.uniprot.org/uniprot/G1MGQ6 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9646:MYOZ3 ^@ http://purl.uniprot.org/uniprot/G1LD46 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/9646:TSPAN13 ^@ http://purl.uniprot.org/uniprot/G1LVH0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:FAM32A ^@ http://purl.uniprot.org/uniprot/A0A7N5KC65 ^@ Similarity ^@ Belongs to the FAM32 family. http://togogenome.org/gene/9646:C17H9orf64 ^@ http://purl.uniprot.org/uniprot/D2H0P0 ^@ Function|||Similarity ^@ Belongs to the QNG1 protein family.|||Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly. http://togogenome.org/gene/9646:RPS6 ^@ http://purl.uniprot.org/uniprot/F2X207 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/9646:BEX4 ^@ http://purl.uniprot.org/uniprot/D2I6F6 ^@ Similarity ^@ Belongs to the BEX family. http://togogenome.org/gene/9646:ATP6V1E2 ^@ http://purl.uniprot.org/uniprot/D2GUA6 ^@ Similarity ^@ Belongs to the V-ATPase E subunit family. http://togogenome.org/gene/9646:SLC25A20 ^@ http://purl.uniprot.org/uniprot/G1L0V2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9646:GNB2 ^@ http://purl.uniprot.org/uniprot/D2HX06 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/9646:CYFIP2 ^@ http://purl.uniprot.org/uniprot/A0A7N5K9J0|||http://purl.uniprot.org/uniprot/G1LI36 ^@ Similarity ^@ Belongs to the CYFIP family. http://togogenome.org/gene/9646:ETFRF1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JE42 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9646:HECTD1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KQT6|||http://purl.uniprot.org/uniprot/D2H9M5 ^@ Function|||Similarity ^@ Belongs to the UPL family. K-HECT subfamily.|||E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. http://togogenome.org/gene/9646:LPL ^@ http://purl.uniprot.org/uniprot/G1L2A1 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Cell membrane|||Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.|||Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted|||Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.|||extracellular matrix http://togogenome.org/gene/9646:PKIB ^@ http://purl.uniprot.org/uniprot/A0A7N5KFI2 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/9646:MRPS26 ^@ http://purl.uniprot.org/uniprot/D2HAC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS26 family.|||Mitochondrion http://togogenome.org/gene/9646:THOC6 ^@ http://purl.uniprot.org/uniprot/G1LFY6 ^@ Similarity ^@ Belongs to the WD repeat THOC6 family. http://togogenome.org/gene/9646:FGFR1OP2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JX31|||http://purl.uniprot.org/uniprot/D2H5Z7 ^@ Similarity ^@ Belongs to the SIKE family. http://togogenome.org/gene/9646:USP45 ^@ http://purl.uniprot.org/uniprot/G1LQW2 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9646:UCHL3 ^@ http://purl.uniprot.org/uniprot/A0A7N5KM99|||http://purl.uniprot.org/uniprot/G1LY51 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/9646:SH2B1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KRY4 ^@ Similarity ^@ Belongs to the SH2B adapter family. http://togogenome.org/gene/9646:LOC100477680 ^@ http://purl.uniprot.org/uniprot/G1L058 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.|||Homotrimer. Functions as a homotrimer binding the FSH hormone heterodimer composed of CGA and FSHB (By similarity). Interacts with ARRB2 (By similarity). Interacts with APPL2; interaction is independent of follicle stimulating hormone stimulation.|||Membrane http://togogenome.org/gene/9646:XIRP1 ^@ http://purl.uniprot.org/uniprot/D2I4K2 ^@ Domain|||Function|||Similarity ^@ Belongs to the Xin family.|||Protects actin filaments from depolymerization.|||Xin repeats bind F-actin. http://togogenome.org/gene/9646:LOC100483773 ^@ http://purl.uniprot.org/uniprot/D2HNC5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:GPAM ^@ http://purl.uniprot.org/uniprot/G1MAU4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPAT/DAPAT family.|||Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.|||Mitochondrion outer membrane http://togogenome.org/gene/9646:BSCL2 ^@ http://purl.uniprot.org/uniprot/G1LIS1 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:CTSW ^@ http://purl.uniprot.org/uniprot/A0A7N5KF48 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/9646:NDUFS3 ^@ http://purl.uniprot.org/uniprot/G1LM91 ^@ Similarity ^@ Belongs to the complex I 30 kDa subunit family. http://togogenome.org/gene/9646:ARG2 ^@ http://purl.uniprot.org/uniprot/D2HRG3 ^@ Cofactor|||Similarity ^@ Belongs to the arginase family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9646:XRN2 ^@ http://purl.uniprot.org/uniprot/G1M1T0 ^@ Function|||Similarity ^@ Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.|||Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. http://togogenome.org/gene/9646:CMTM5 ^@ http://purl.uniprot.org/uniprot/A0A7N5P7S2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:ZC3HAV1 ^@ http://purl.uniprot.org/uniprot/A0A7N5K4N0 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9646:HMGN4 ^@ http://purl.uniprot.org/uniprot/D2I670 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/9646:DRAM2 ^@ http://purl.uniprot.org/uniprot/D2HXF6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:ACVR1C ^@ http://purl.uniprot.org/uniprot/G1M6Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9646:GOT1 ^@ http://purl.uniprot.org/uniprot/D2I671 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/9646:SLC34A3 ^@ http://purl.uniprot.org/uniprot/G1MDA4 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the SLC34A transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:LOC109490817 ^@ http://purl.uniprot.org/uniprot/D2HWJ2 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9646:PDSS2 ^@ http://purl.uniprot.org/uniprot/G1LN41 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9646:LOC100478626 ^@ http://purl.uniprot.org/uniprot/D2I4D4 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:INSM2 ^@ http://purl.uniprot.org/uniprot/D2HKI4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:TSR1 ^@ http://purl.uniprot.org/uniprot/D2H8B1 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9646:MTO1 ^@ http://purl.uniprot.org/uniprot/G1LMJ9 ^@ Function|||Similarity ^@ Belongs to the MnmG family.|||Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. http://togogenome.org/gene/9646:ATP5MD ^@ http://purl.uniprot.org/uniprot/D2GXX9 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion membrane http://togogenome.org/gene/9646:MTX3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JER4|||http://purl.uniprot.org/uniprot/G1MAX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metaxin family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9646:NR5A1 ^@ http://purl.uniprot.org/uniprot/D2HDG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR5 subfamily.|||Nucleus http://togogenome.org/gene/9646:VPS33A ^@ http://purl.uniprot.org/uniprot/D2GVX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STXBP/unc-18/SEC1 family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||clathrin-coated vesicle http://togogenome.org/gene/9646:PATL2 ^@ http://purl.uniprot.org/uniprot/A0A7N5KRF4 ^@ Similarity ^@ Belongs to the PAT1 family. http://togogenome.org/gene/9646:FGF13 ^@ http://purl.uniprot.org/uniprot/A0A7N5P3Y9|||http://purl.uniprot.org/uniprot/G1MCK0 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9646:E2F7 ^@ http://purl.uniprot.org/uniprot/D2I4G6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9646:APOOL ^@ http://purl.uniprot.org/uniprot/A0A7N5JKU1|||http://purl.uniprot.org/uniprot/A0A7N5KBH6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:LOC100482789 ^@ http://purl.uniprot.org/uniprot/D2HWJ2 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9646:GAREM1 ^@ http://purl.uniprot.org/uniprot/D2HQL4 ^@ Similarity ^@ Belongs to the GAREM family. http://togogenome.org/gene/9646:METAP2 ^@ http://purl.uniprot.org/uniprot/D2HBJ9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M24A family.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/9646:LOC100474000 ^@ http://purl.uniprot.org/uniprot/G1MNB6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:LOC100469047 ^@ http://purl.uniprot.org/uniprot/A0A7N5KL52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9646:LYRM7 ^@ http://purl.uniprot.org/uniprot/G1MHE1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.|||Belongs to the complex I LYR family.|||Interacts with UQCRFS1.|||Mitochondrion matrix http://togogenome.org/gene/9646:SLC25A40 ^@ http://purl.uniprot.org/uniprot/G1L2Y7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:NCAPG ^@ http://purl.uniprot.org/uniprot/D2I3G0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CND3 (condensin subunit 3) family.|||Chromosome http://togogenome.org/gene/9646:LOC100465110 ^@ http://purl.uniprot.org/uniprot/D2HZU2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9646:ACTL7B ^@ http://purl.uniprot.org/uniprot/D2H478 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9646:ZNF532 ^@ http://purl.uniprot.org/uniprot/A0A7N5JA96 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9646:ENKD1 ^@ http://purl.uniprot.org/uniprot/G1MGK6 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9646:LOC100480861 ^@ http://purl.uniprot.org/uniprot/D2HMS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/9646:CDK7 ^@ http://purl.uniprot.org/uniprot/G1L901 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. http://togogenome.org/gene/9646:RHBG ^@ http://purl.uniprot.org/uniprot/A0A7N5KNF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/9646:PGK1 ^@ http://purl.uniprot.org/uniprot/G1MGY6 ^@ Similarity|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Monomer. http://togogenome.org/gene/9646:NDEL1 ^@ http://purl.uniprot.org/uniprot/G1L6P4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nudE family.|||centrosome|||kinetochore|||spindle http://togogenome.org/gene/9646:SNX2 ^@ http://purl.uniprot.org/uniprot/A0A7N5P5U2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome membrane|||Endosome membrane|||Membrane|||lamellipodium http://togogenome.org/gene/9646:TGS1 ^@ http://purl.uniprot.org/uniprot/G1L4R9 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family. http://togogenome.org/gene/9646:NAA35 ^@ http://purl.uniprot.org/uniprot/A0A7N5JJL2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.|||Belongs to the MAK10 family.|||Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.|||Cytoplasm http://togogenome.org/gene/9646:AMBP ^@ http://purl.uniprot.org/uniprot/G1M2K1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family.|||In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.|||Kunitz-type serine protease inhibitor. Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation. Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases.|||Mitochondrion inner membrane|||Monomer. Also occurs as a complex with tryptase in mast cells.|||Nucleus membrane|||extracellular matrix http://togogenome.org/gene/9646:FGF18 ^@ http://purl.uniprot.org/uniprot/A0A7N5JGX8 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9646:ETV1 ^@ http://purl.uniprot.org/uniprot/D2HPJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9646:MRPS12 ^@ http://purl.uniprot.org/uniprot/G1LQ39 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS12 family. http://togogenome.org/gene/9646:CSNK1G1 ^@ http://purl.uniprot.org/uniprot/G1L735 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. http://togogenome.org/gene/9646:NFE2L2 ^@ http://purl.uniprot.org/uniprot/G1LZQ0 ^@ Similarity ^@ Belongs to the bZIP family. CNC subfamily. http://togogenome.org/gene/9646:SLC7A9 ^@ http://purl.uniprot.org/uniprot/G1MAI1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:LOC100479124 ^@ http://purl.uniprot.org/uniprot/D2I0D6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:STARD3NL ^@ http://purl.uniprot.org/uniprot/G1M6S4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STARD3 family.|||Membrane http://togogenome.org/gene/9646:DEFB127 ^@ http://purl.uniprot.org/uniprot/G1LXR3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9646:TEFM ^@ http://purl.uniprot.org/uniprot/G1LG24 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TEFM family.|||Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery.|||mitochondrion nucleoid http://togogenome.org/gene/9646:CENPC ^@ http://purl.uniprot.org/uniprot/G1L9R7 ^@ Similarity ^@ Belongs to the CENP-C/MIF2 family. http://togogenome.org/gene/9646:GPHB5 ^@ http://purl.uniprot.org/uniprot/D2GYJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/9646:LOC100472982 ^@ http://purl.uniprot.org/uniprot/D2I6U0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:IL5RA ^@ http://purl.uniprot.org/uniprot/G1M7H0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:VCAM1 ^@ http://purl.uniprot.org/uniprot/G1LSS1 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9646:FEN1 ^@ http://purl.uniprot.org/uniprot/D2HUF5 ^@ Function ^@ Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. http://togogenome.org/gene/9646:DCLRE1C ^@ http://purl.uniprot.org/uniprot/D2I3V7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/9646:PEX5L ^@ http://purl.uniprot.org/uniprot/A0A7N5JKF0|||http://purl.uniprot.org/uniprot/A0A7N5KI43|||http://purl.uniprot.org/uniprot/A0A7N5KIT8 ^@ Similarity ^@ Belongs to the peroxisomal targeting signal receptor family. http://togogenome.org/gene/9646:PTPRG ^@ http://purl.uniprot.org/uniprot/G1MA58|||http://purl.uniprot.org/uniprot/G1MA60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.|||Membrane http://togogenome.org/gene/9646:TMEM205 ^@ http://purl.uniprot.org/uniprot/D2HGW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM205 family.|||Membrane http://togogenome.org/gene/9646:NDUFAF4 ^@ http://purl.uniprot.org/uniprot/A0A7N5K2H8 ^@ Similarity|||Subunit ^@ Belongs to the NDUFAF4 family.|||Binds calmodulin. Interacts with NDUFAF3. http://togogenome.org/gene/9646:CDC6 ^@ http://purl.uniprot.org/uniprot/D2HR21 ^@ Similarity ^@ Belongs to the CDC6/cdc18 family. http://togogenome.org/gene/9646:POLR2I ^@ http://purl.uniprot.org/uniprot/D2HFU4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.|||nucleolus http://togogenome.org/gene/9646:FAM124A ^@ http://purl.uniprot.org/uniprot/G1LZX6 ^@ Similarity ^@ Belongs to the FAM124 family. http://togogenome.org/gene/9646:LOC100484909 ^@ http://purl.uniprot.org/uniprot/A0A7N5JVU0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:BNIP3 ^@ http://purl.uniprot.org/uniprot/G1LWI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIP3 family.|||Membrane http://togogenome.org/gene/9646:ACTR8 ^@ http://purl.uniprot.org/uniprot/D2I1E3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the actin family. ARP8 subfamily.|||Chromosome|||Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core (By similarity).|||Nucleus|||Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize (By similarity).|||Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex (By similarity). http://togogenome.org/gene/9646:PEX12 ^@ http://purl.uniprot.org/uniprot/D2HML4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pex2/pex10/pex12 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9646:LOC100478510 ^@ http://purl.uniprot.org/uniprot/D2HV38 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/9646:CDC37L1 ^@ http://purl.uniprot.org/uniprot/D2HPJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC37 family.|||Cytoplasm http://togogenome.org/gene/9646:HNRNPC ^@ http://purl.uniprot.org/uniprot/D2HYC2 ^@ Similarity ^@ Belongs to the RRM HNRPC family. RALY subfamily. http://togogenome.org/gene/9646:CHRNG ^@ http://purl.uniprot.org/uniprot/G1MDK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9646:MBTPS2 ^@ http://purl.uniprot.org/uniprot/A0A7N5K4E3 ^@ Similarity ^@ Belongs to the peptidase M50A family. http://togogenome.org/gene/9646:ACADL ^@ http://purl.uniprot.org/uniprot/G1LEE6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acyl-CoA dehydrogenase family.|||Homotetramer.|||Mitochondrion matrix http://togogenome.org/gene/9646:STAC ^@ http://purl.uniprot.org/uniprot/D2GZR9 ^@ Subcellular Location Annotation ^@ sarcolemma http://togogenome.org/gene/9646:ARL4C ^@ http://purl.uniprot.org/uniprot/D2H830 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9646:RBBP7 ^@ http://purl.uniprot.org/uniprot/A0A7N5JLH6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:UBE2S ^@ http://purl.uniprot.org/uniprot/G1LAQ6 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9646:FTSJ1 ^@ http://purl.uniprot.org/uniprot/G1M262 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.|||Cytoplasm|||Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. http://togogenome.org/gene/9646:MGAT2 ^@ http://purl.uniprot.org/uniprot/D2HIE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 16 (GT16) protein family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:BCCIP ^@ http://purl.uniprot.org/uniprot/A0A7N5JPH3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCP1 family.|||May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).|||Nucleus|||spindle pole http://togogenome.org/gene/9646:BCORL1 ^@ http://purl.uniprot.org/uniprot/A0A7N5K2Y5|||http://purl.uniprot.org/uniprot/G1M8Y0 ^@ Similarity ^@ Belongs to the BCOR family. http://togogenome.org/gene/9646:RPL9 ^@ http://purl.uniprot.org/uniprot/D9ZLV7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL6 family. http://togogenome.org/gene/9646:AGTR1 ^@ http://purl.uniprot.org/uniprot/D2HWD9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C. http://togogenome.org/gene/9646:TMPRSS11D ^@ http://purl.uniprot.org/uniprot/G1L9Z8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Membrane http://togogenome.org/gene/9646:ISY1 ^@ http://purl.uniprot.org/uniprot/G1MA22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ISY1 family.|||Nucleus http://togogenome.org/gene/9646:SF3A2 ^@ http://purl.uniprot.org/uniprot/D2HTL8 ^@ Similarity ^@ Belongs to the SF3A2 family. http://togogenome.org/gene/9646:RNFT2 ^@ http://purl.uniprot.org/uniprot/G1M1C9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:UBE2H ^@ http://purl.uniprot.org/uniprot/A0A7N5KHJ1 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9646:LOC100483670 ^@ http://purl.uniprot.org/uniprot/G1LTA5 ^@ Similarity ^@ Belongs to the CBP3 family. http://togogenome.org/gene/9646:MED19 ^@ http://purl.uniprot.org/uniprot/G1M7Q7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 19 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9646:GABRA2 ^@ http://purl.uniprot.org/uniprot/G1L9Q6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||dendrite http://togogenome.org/gene/9646:LOC100464289 ^@ http://purl.uniprot.org/uniprot/G1L379 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. http://togogenome.org/gene/9646:CCDC47 ^@ http://purl.uniprot.org/uniprot/G1L946 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC47 family.|||Rough endoplasmic reticulum membrane http://togogenome.org/gene/9646:EIF4A2 ^@ http://purl.uniprot.org/uniprot/G1L2C1 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family. eIF4A subfamily.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9646:EHD2 ^@ http://purl.uniprot.org/uniprot/D2H814 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/9646:GLI3 ^@ http://purl.uniprot.org/uniprot/D2GYG0 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/9646:CMBL ^@ http://purl.uniprot.org/uniprot/D2H9W7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dienelactone hydrolase family.|||cytosol http://togogenome.org/gene/9646:TCL1A ^@ http://purl.uniprot.org/uniprot/G1LIZ1 ^@ Similarity ^@ Belongs to the TCL1 family. http://togogenome.org/gene/9646:A4GALT ^@ http://purl.uniprot.org/uniprot/D2HVM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 32 family.|||Golgi apparatus membrane http://togogenome.org/gene/9646:DOP1B ^@ http://purl.uniprot.org/uniprot/D2H5T8 ^@ Similarity ^@ Belongs to the dopey family. http://togogenome.org/gene/9646:SCG2 ^@ http://purl.uniprot.org/uniprot/D2H9R7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chromogranin/secretogranin protein family.|||Interacts with Secretogranin III/SCG3.|||Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules.|||Secreted http://togogenome.org/gene/9646:ANAPC1 ^@ http://purl.uniprot.org/uniprot/D2HPH2 ^@ Similarity ^@ Belongs to the APC1 family. http://togogenome.org/gene/9646:MSMP ^@ http://purl.uniprot.org/uniprot/D2HAL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-microseminoprotein family.|||Secreted http://togogenome.org/gene/9646:CRX ^@ http://purl.uniprot.org/uniprot/D2H811 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:NSUN3 ^@ http://purl.uniprot.org/uniprot/G1L6T2 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/9646:LOC100483551 ^@ http://purl.uniprot.org/uniprot/D2I489 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:GPR15 ^@ http://purl.uniprot.org/uniprot/D2HSL3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:ROCK1 ^@ http://purl.uniprot.org/uniprot/G1LJU8 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by RHOA binding. Inhibited by Y-27632.|||Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.|||Cytoplasm|||Homodimer.|||Membrane|||Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. http://togogenome.org/gene/9646:UNC5CL ^@ http://purl.uniprot.org/uniprot/D2I3I3 ^@ Similarity ^@ Belongs to the unc-5 family. http://togogenome.org/gene/9646:ZNF330 ^@ http://purl.uniprot.org/uniprot/D2HWA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOA36 family.|||centromere|||nucleolus http://togogenome.org/gene/9646:EFTUD2 ^@ http://purl.uniprot.org/uniprot/G1MJ97 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:LOC100479852 ^@ http://purl.uniprot.org/uniprot/G1MLP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9646:SKA3 ^@ http://purl.uniprot.org/uniprot/A0A7N5KHW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SKA3 family.|||kinetochore|||spindle http://togogenome.org/gene/9646:SLC22A18 ^@ http://purl.uniprot.org/uniprot/G1L689 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:MC5R ^@ http://purl.uniprot.org/uniprot/G1MLW2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins. http://togogenome.org/gene/9646:PDE1B ^@ http://purl.uniprot.org/uniprot/A0A7N5JNG4|||http://purl.uniprot.org/uniprot/D2HM59|||http://purl.uniprot.org/uniprot/G1L2M9 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9646:MEF2C ^@ http://purl.uniprot.org/uniprot/A0A7N5KD46|||http://purl.uniprot.org/uniprot/G1M3T0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:SGMS1 ^@ http://purl.uniprot.org/uniprot/G1L163 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/9646:ZSCAN30 ^@ http://purl.uniprot.org/uniprot/G1L0Q4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:TRAK2 ^@ http://purl.uniprot.org/uniprot/D2H2Q7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the milton family.|||Early endosome|||Mitochondrion http://togogenome.org/gene/9646:SLC6A7 ^@ http://purl.uniprot.org/uniprot/G1LE93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9646:MYD88 ^@ http://purl.uniprot.org/uniprot/D2GZQ7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:NMI ^@ http://purl.uniprot.org/uniprot/G1M320 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NMI family.|||Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/9646:HSD17B11 ^@ http://purl.uniprot.org/uniprot/G1L975 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9646:CCDC130 ^@ http://purl.uniprot.org/uniprot/G1M2N3 ^@ Similarity ^@ Belongs to the CWC16 family. http://togogenome.org/gene/9646:GALNT7 ^@ http://purl.uniprot.org/uniprot/D2GUW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:KDM5A ^@ http://purl.uniprot.org/uniprot/G1LCY8 ^@ Similarity ^@ Belongs to the JARID1 histone demethylase family. http://togogenome.org/gene/9646:ARL5A ^@ http://purl.uniprot.org/uniprot/G1LQ72 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9646:MLH3 ^@ http://purl.uniprot.org/uniprot/D2GZX5 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/9646:ADORA1 ^@ http://purl.uniprot.org/uniprot/D2HSE9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. http://togogenome.org/gene/9646:ANAPC10 ^@ http://purl.uniprot.org/uniprot/D2H3Q0 ^@ Similarity ^@ Belongs to the APC10 family. http://togogenome.org/gene/9646:LOC100475093 ^@ http://purl.uniprot.org/uniprot/A0A7N5KED1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:HOXD13 ^@ http://purl.uniprot.org/uniprot/D2I1G4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9646:MRPL24 ^@ http://purl.uniprot.org/uniprot/G1M8U4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/9646:DHH ^@ http://purl.uniprot.org/uniprot/D2HWS2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the hedgehog family.|||Cell membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane|||Multimer.|||The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.|||The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development. http://togogenome.org/gene/9646:JOSD2 ^@ http://purl.uniprot.org/uniprot/A0A7N5P4F2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:COQ7 ^@ http://purl.uniprot.org/uniprot/G1LWZ2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ7 family.|||Binds 2 iron ions per subunit.|||Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:LITAFD ^@ http://purl.uniprot.org/uniprot/D2HCQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/9646:SOAT2 ^@ http://purl.uniprot.org/uniprot/G1M0E6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:NSF ^@ http://purl.uniprot.org/uniprot/G1LC54 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. http://togogenome.org/gene/9646:CALB2 ^@ http://purl.uniprot.org/uniprot/D2HFV9 ^@ Function|||Similarity ^@ Belongs to the calbindin family.|||Calretinin is a calcium-binding protein which is abundant in auditory neurons. http://togogenome.org/gene/9646:HMBS ^@ http://purl.uniprot.org/uniprot/G1KZJ1 ^@ Similarity ^@ Belongs to the HMBS family. http://togogenome.org/gene/9646:RGS4 ^@ http://purl.uniprot.org/uniprot/A0A7N5JXW7 ^@ Function ^@ Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. http://togogenome.org/gene/9646:ZAR1L ^@ http://purl.uniprot.org/uniprot/A0A7N5JEW6 ^@ Similarity|||Subunit ^@ Belongs to the ZAR1 family.|||Interacts with YBX2. http://togogenome.org/gene/9646:OSBPL3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JWU7|||http://purl.uniprot.org/uniprot/A0A7N5KNK7|||http://purl.uniprot.org/uniprot/G1LHM0 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9646:ARF3 ^@ http://purl.uniprot.org/uniprot/D2HWS6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/9646:HNRNPH2 ^@ http://purl.uniprot.org/uniprot/D2I2N0 ^@ Subcellular Location Annotation ^@ nucleoplasm http://togogenome.org/gene/9646:LOC100467027 ^@ http://purl.uniprot.org/uniprot/G1LGF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Membrane http://togogenome.org/gene/9646:TSSK6 ^@ http://purl.uniprot.org/uniprot/G1MM19 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9646:LOC100464593 ^@ http://purl.uniprot.org/uniprot/G1LZR3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9646:GALNT11 ^@ http://purl.uniprot.org/uniprot/D2H1U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:KCNV1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KFZ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.|||Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.|||Membrane|||Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes. http://togogenome.org/gene/9646:LOC100484465 ^@ http://purl.uniprot.org/uniprot/A0A7N5K4U1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:PLPPR1 ^@ http://purl.uniprot.org/uniprot/G1L1E5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9646:KCNK10 ^@ http://purl.uniprot.org/uniprot/A0A7N5P8U6|||http://purl.uniprot.org/uniprot/G1L3G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9646:CPD ^@ http://purl.uniprot.org/uniprot/D2GU00 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9646:DNM2 ^@ http://purl.uniprot.org/uniprot/A0A7N5KJC2|||http://purl.uniprot.org/uniprot/G1LX99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.|||Cytoplasm http://togogenome.org/gene/9646:PSME1 ^@ http://purl.uniprot.org/uniprot/G1MDG8 ^@ Similarity ^@ Belongs to the PA28 family. http://togogenome.org/gene/9646:SFXN2 ^@ http://purl.uniprot.org/uniprot/D2GXW8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9646:CTPS2 ^@ http://purl.uniprot.org/uniprot/G1LV08 ^@ Function|||Similarity ^@ Belongs to the CTP synthase family.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. http://togogenome.org/gene/9646:LOC100479104 ^@ http://purl.uniprot.org/uniprot/G1MML8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:CAVIN4 ^@ http://purl.uniprot.org/uniprot/A0A7N5K393 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/9646:LOC100468377 ^@ http://purl.uniprot.org/uniprot/D2HZC2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:GPX5 ^@ http://purl.uniprot.org/uniprot/A0A7N5P2N0|||http://purl.uniprot.org/uniprot/G1M5L9 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/9646:POP5 ^@ http://purl.uniprot.org/uniprot/D2I158 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family. http://togogenome.org/gene/9646:CDC14B ^@ http://purl.uniprot.org/uniprot/A0A7N5KFP6 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily. http://togogenome.org/gene/9646:RPL5 ^@ http://purl.uniprot.org/uniprot/D9ZLV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL18 family.|||Cytoplasm http://togogenome.org/gene/9646:PAQR7 ^@ http://purl.uniprot.org/uniprot/G1MPF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9646:BVES ^@ http://purl.uniprot.org/uniprot/D2H5S1 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/9646:C16H11orf49 ^@ http://purl.uniprot.org/uniprot/A0A7N5JEZ1|||http://purl.uniprot.org/uniprot/G1LKS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSTPP1 family.|||cytoskeleton http://togogenome.org/gene/9646:KRT35 ^@ http://purl.uniprot.org/uniprot/D2HIQ9 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9646:LACTB2 ^@ http://purl.uniprot.org/uniprot/G1LIE5 ^@ Function|||Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.|||Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability. http://togogenome.org/gene/9646:UQCRQ ^@ http://purl.uniprot.org/uniprot/D2GVI2|||http://purl.uniprot.org/uniprot/Q2L897 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCRQ/QCR8 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1 (By similarity). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Interacts with UQCC6 (By similarity).|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9646:ANO6 ^@ http://purl.uniprot.org/uniprot/A0A7N5KRZ0|||http://purl.uniprot.org/uniprot/G1MBD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:NRP2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JBX0 ^@ Caution|||Similarity ^@ Belongs to the neuropilin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:CDKN1B ^@ http://purl.uniprot.org/uniprot/G1LW64 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/9646:TARS1 ^@ http://purl.uniprot.org/uniprot/G1L9U5 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9646:ORC2 ^@ http://purl.uniprot.org/uniprot/G1LHB8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC2 family.|||Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.|||Component of the origin recognition complex (ORC).|||Nucleus http://togogenome.org/gene/9646:GPR155 ^@ http://purl.uniprot.org/uniprot/G1M0P4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:DYNC2LI1 ^@ http://purl.uniprot.org/uniprot/G1LGN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light intermediate chain family.|||centrosome|||cilium|||cilium axoneme|||cilium basal body http://togogenome.org/gene/9646:KRT222 ^@ http://purl.uniprot.org/uniprot/D2HR27 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9646:SEMA5B ^@ http://purl.uniprot.org/uniprot/A0A7N5KF69 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:LOC100466939 ^@ http://purl.uniprot.org/uniprot/D2HZU2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9646:MSN ^@ http://purl.uniprot.org/uniprot/A0A7N5JF56 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton|||microvillus http://togogenome.org/gene/9646:B3GNT8 ^@ http://purl.uniprot.org/uniprot/D2HMT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:PRND ^@ http://purl.uniprot.org/uniprot/D2HQS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prion family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:LOC100473055 ^@ http://purl.uniprot.org/uniprot/G1MJV8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:HIRIP3 ^@ http://purl.uniprot.org/uniprot/D2HX43 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:LOC100467289 ^@ http://purl.uniprot.org/uniprot/G1MP84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9646:SAR1B ^@ http://purl.uniprot.org/uniprot/G1MHM6 ^@ Similarity ^@ Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/9646:CHST10 ^@ http://purl.uniprot.org/uniprot/G1MB03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:CLASP1 ^@ http://purl.uniprot.org/uniprot/G1LF58 ^@ Subcellular Location Annotation ^@ kinetochore http://togogenome.org/gene/9646:TMED1 ^@ http://purl.uniprot.org/uniprot/D2HGX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9646:GLE1 ^@ http://purl.uniprot.org/uniprot/G1MAN3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GLE1 family.|||Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/9646:PSMC2 ^@ http://purl.uniprot.org/uniprot/G1M9S2 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9646:IL6 ^@ http://purl.uniprot.org/uniprot/H2DL91 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-6 superfamily.|||Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; first binds to IL6R to associate with the signaling subunit IL6ST. Interacts with IL6R (via the N-terminal ectodomain); this interaction may be affected by IL6R-binding with SORL1, hence decreasing IL6 cis signaling. Interacts with SORL1 (via the N-terminal ectodomain); this interaction leads to IL6 internalization and lysosomal degradation. May form a trimeric complex with the soluble SORL1 ectodomain and soluble IL6R receptor; this interaction might stabilize circulating IL6, hence promoting IL6 trans signaling.|||Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.|||IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury (By similarity). In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells. Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Required to drive naive CD4(+) T cells to the Th17 lineage. Also required for proliferation of myeloma cells and the survival of plasmablast cells.|||Secreted http://togogenome.org/gene/9646:PNLIPRP3 ^@ http://purl.uniprot.org/uniprot/G1M5Q3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9646:GCNT1 ^@ http://purl.uniprot.org/uniprot/D2HPX9 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:GLRX ^@ http://purl.uniprot.org/uniprot/D2HYF9 ^@ Function|||Similarity ^@ Belongs to the glutaredoxin family.|||Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. http://togogenome.org/gene/9646:TMEM225 ^@ http://purl.uniprot.org/uniprot/G1M061 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:LOC100479287 ^@ http://purl.uniprot.org/uniprot/D2I475 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:TECR ^@ http://purl.uniprot.org/uniprot/G1LY96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:TAF1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KI20|||http://purl.uniprot.org/uniprot/D2I1M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF1 family.|||Nucleus http://togogenome.org/gene/9646:IWS1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KJZ2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:TM9SF1 ^@ http://purl.uniprot.org/uniprot/D2HG51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/9646:CPA4 ^@ http://purl.uniprot.org/uniprot/A0A7N5KHX7|||http://purl.uniprot.org/uniprot/G1LFX7 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9646:STXBP3 ^@ http://purl.uniprot.org/uniprot/G1LCM9 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9646:PEG3 ^@ http://purl.uniprot.org/uniprot/A0A7N5P0T1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:TRMT6 ^@ http://purl.uniprot.org/uniprot/D2HR95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRM6/GCD10 family.|||Nucleus http://togogenome.org/gene/9646:EMP2 ^@ http://purl.uniprot.org/uniprot/A0A7N5P9K1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the PMP-22/EMP/MP20 family.|||Cell membrane|||Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion.|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Membrane raft|||Nucleus|||perinuclear region http://togogenome.org/gene/9646:TBXA2R ^@ http://purl.uniprot.org/uniprot/G1LGK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:KCNJ4 ^@ http://purl.uniprot.org/uniprot/D2GZJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9646:KCNJ11 ^@ http://purl.uniprot.org/uniprot/D2HRL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.|||Membrane http://togogenome.org/gene/9646:RHBDD1 ^@ http://purl.uniprot.org/uniprot/G1LC53 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:MEIG1 ^@ http://purl.uniprot.org/uniprot/D2HVH0 ^@ Function|||Similarity ^@ Belongs to the MEIG1 family.|||Essential for spermiogenesis. http://togogenome.org/gene/9646:MED28 ^@ http://purl.uniprot.org/uniprot/D2H3S5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 28 family.|||Nucleus http://togogenome.org/gene/9646:LYZ ^@ http://purl.uniprot.org/uniprot/G1LZC7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9646:GHRHR ^@ http://purl.uniprot.org/uniprot/G1LJT4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:IGFBP5 ^@ http://purl.uniprot.org/uniprot/D2GXE6 ^@ Caution|||Function|||Subcellular Location Annotation ^@ IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9646:LMX1A ^@ http://purl.uniprot.org/uniprot/G1LJ50 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:SEMA6D ^@ http://purl.uniprot.org/uniprot/A0A7N5K4L6|||http://purl.uniprot.org/uniprot/A0A7N5P8U1|||http://purl.uniprot.org/uniprot/G1L5L8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:KEG54_p13 ^@ http://purl.uniprot.org/uniprot/A5JFJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 1 family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9646:BECN1 ^@ http://purl.uniprot.org/uniprot/A0A7N5K7W5|||http://purl.uniprot.org/uniprot/A0A7N5KHM3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.|||Belongs to the beclin family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Endosome membrane|||Membrane|||Mitochondrion membrane|||Plays a central role in autophagy.|||autophagosome|||trans-Golgi network membrane http://togogenome.org/gene/9646:PTGS1 ^@ http://purl.uniprot.org/uniprot/G1L1M8 ^@ Caution|||Similarity ^@ Belongs to the prostaglandin G/H synthase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:PITX2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JAK8|||http://purl.uniprot.org/uniprot/A0A7N5KBN9|||http://purl.uniprot.org/uniprot/D2H704 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9646:GDF15 ^@ http://purl.uniprot.org/uniprot/D2GV32 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9646:MCM7 ^@ http://purl.uniprot.org/uniprot/A0A7N5JDX4|||http://purl.uniprot.org/uniprot/G1LXH5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Nucleus http://togogenome.org/gene/9646:MCM3 ^@ http://purl.uniprot.org/uniprot/G1LPP7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/9646:TCTN2 ^@ http://purl.uniprot.org/uniprot/D2GW03 ^@ Similarity|||Subunit ^@ Belongs to the tectonic family.|||Part of the tectonic-like complex (also named B9 complex). http://togogenome.org/gene/9646:ATAT1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JHA3|||http://purl.uniprot.org/uniprot/G1M3R3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Autoacetylation strongly increases tubulin acetylation.|||Belongs to the acetyltransferase ATAT1 family.|||Component of the BBSome complex. Interacts with AP2 alpha-adaptins, including AP2A2, but not with AP1 gamma-adaptin (AP1G1/AP1G2); this interaction is required for efficient alpha-tubulin acetylation, hence clathrin-coated pits are sites of microtubule acetylation.|||Cytoplasm|||Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.|||axon|||clathrin-coated pit|||cytoskeleton|||focal adhesion|||spindle http://togogenome.org/gene/9646:TBX5 ^@ http://purl.uniprot.org/uniprot/D2HSK1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9646:LOC100476935 ^@ http://purl.uniprot.org/uniprot/D2I5X4 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:PIGH ^@ http://purl.uniprot.org/uniprot/D2HRG4 ^@ Similarity ^@ Belongs to the PIGH family. http://togogenome.org/gene/9646:MED4 ^@ http://purl.uniprot.org/uniprot/D2HB80 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 4 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9646:PLCB3 ^@ http://purl.uniprot.org/uniprot/G1MI45 ^@ Cofactor|||Function ^@ Binds 1 Ca(2+) ion per subunit.|||The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. http://togogenome.org/gene/9646:LRRC8D ^@ http://purl.uniprot.org/uniprot/D2HJK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:VIM ^@ http://purl.uniprot.org/uniprot/G1LVM5 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9646:TNFSF4 ^@ http://purl.uniprot.org/uniprot/A0A7N5P907 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9646:HSPA4 ^@ http://purl.uniprot.org/uniprot/D2GVI6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 70 family.|||Cytoplasm|||Interacts with TJP1/ZO-1. http://togogenome.org/gene/9646:LHX4 ^@ http://purl.uniprot.org/uniprot/G1L861 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:S100A4 ^@ http://purl.uniprot.org/uniprot/D2HJR5 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9646:FERMT2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JDB0 ^@ Similarity ^@ Belongs to the kindlin family. http://togogenome.org/gene/9646:ACSL1 ^@ http://purl.uniprot.org/uniprot/D2GY67 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.|||Endoplasmic reticulum membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9646:WARS1 ^@ http://purl.uniprot.org/uniprot/A0A7N5P2W1 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9646:DNAJC5B ^@ http://purl.uniprot.org/uniprot/D2H417 ^@ PTM|||Subcellular Location Annotation|||Subunit ^@ Interacts with the chaperone complex consisting of HSC70 and SGTA.|||Membrane|||Palmitoylated. http://togogenome.org/gene/9646:DDX50 ^@ http://purl.uniprot.org/uniprot/G1MI27 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily. http://togogenome.org/gene/9646:DEFB124 ^@ http://purl.uniprot.org/uniprot/G1M577 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9646:ATG2B ^@ http://purl.uniprot.org/uniprot/G1LB52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG2 family.|||Endoplasmic reticulum membrane|||Lipid droplet|||Preautophagosomal structure membrane http://togogenome.org/gene/9646:ELAPOR1 ^@ http://purl.uniprot.org/uniprot/G1LD17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELAPOR family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:NR2C1 ^@ http://purl.uniprot.org/uniprot/G1L677 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9646:STMN2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JT04 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/9646:MARVELD3 ^@ http://purl.uniprot.org/uniprot/A0A7N5P8R5|||http://purl.uniprot.org/uniprot/G1L6I4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:GPNMB ^@ http://purl.uniprot.org/uniprot/G1L9T3 ^@ Similarity ^@ Belongs to the PMEL/NMB family. http://togogenome.org/gene/9646:SLC41A2 ^@ http://purl.uniprot.org/uniprot/D2H1T6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/9646:LRRC8E ^@ http://purl.uniprot.org/uniprot/D2HI92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:MMAA ^@ http://purl.uniprot.org/uniprot/G1ME12 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. http://togogenome.org/gene/9646:CAMK4 ^@ http://purl.uniprot.org/uniprot/G1M260 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9646:GLRA2 ^@ http://purl.uniprot.org/uniprot/A0A7N5K5T1|||http://purl.uniprot.org/uniprot/G1LIA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/9646:ATP10B ^@ http://purl.uniprot.org/uniprot/D2GUJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9646:KRT36 ^@ http://purl.uniprot.org/uniprot/D2HIR0 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9646:LOC100468886 ^@ http://purl.uniprot.org/uniprot/G1MN66 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:LOC100479707 ^@ http://purl.uniprot.org/uniprot/D2I7Y7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:LALBA ^@ http://purl.uniprot.org/uniprot/D2HWT5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glycosyl hydrolase 22 family.|||Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).|||Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins. http://togogenome.org/gene/9646:NAB1 ^@ http://purl.uniprot.org/uniprot/D2H878 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAB family.|||Homomultimers may associate with EGR1 bound to DNA.|||Nucleus http://togogenome.org/gene/9646:TAF11 ^@ http://purl.uniprot.org/uniprot/D2GYX5 ^@ Similarity ^@ Belongs to the TAF11 family. http://togogenome.org/gene/9646:PFKFB4 ^@ http://purl.uniprot.org/uniprot/G1L2T1 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/9646:MCM8 ^@ http://purl.uniprot.org/uniprot/G1LVR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Chromosome|||Nucleus http://togogenome.org/gene/9646:DNTTIP1 ^@ http://purl.uniprot.org/uniprot/D2HZ02 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:NDP ^@ http://purl.uniprot.org/uniprot/D2HZ86 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9646:SUPT6H ^@ http://purl.uniprot.org/uniprot/G1LDR5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT6 family.|||Nucleus|||Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). http://togogenome.org/gene/9646:AP5M1 ^@ http://purl.uniprot.org/uniprot/G1L6I9 ^@ Subcellular Location Annotation|||Subunit ^@ Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane|||Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1. http://togogenome.org/gene/9646:DNAAF3 ^@ http://purl.uniprot.org/uniprot/G1L9X8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNAAF3 family.|||Cytoplasm|||Dynein axonemal particle|||Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia. http://togogenome.org/gene/9646:KCNG1 ^@ http://purl.uniprot.org/uniprot/D2GVM5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:FUNDC2 ^@ http://purl.uniprot.org/uniprot/A0A7N5K165|||http://purl.uniprot.org/uniprot/G1LZQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FUN14 family.|||Mitochondrion outer membrane http://togogenome.org/gene/9646:NT5C3A ^@ http://purl.uniprot.org/uniprot/A0A7N5JMU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrimidine 5'-nucleotidase family.|||Cytoplasm http://togogenome.org/gene/9646:TPRA1 ^@ http://purl.uniprot.org/uniprot/D2H7B4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0359 family.|||Membrane http://togogenome.org/gene/9646:NUTF2 ^@ http://purl.uniprot.org/uniprot/D2H9F9 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/9646:ITPA ^@ http://purl.uniprot.org/uniprot/G1LWZ8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Cytoplasm|||Homodimer.|||Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. http://togogenome.org/gene/9646:ATP6V0C ^@ http://purl.uniprot.org/uniprot/D2HV78 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.|||Vacuole membrane|||clathrin-coated vesicle membrane|||synaptic vesicle membrane http://togogenome.org/gene/9646:S100A2 ^@ http://purl.uniprot.org/uniprot/G1M0I8 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9646:AIF1 ^@ http://purl.uniprot.org/uniprot/G1LS81 ^@ Subcellular Location Annotation ^@ ruffle membrane http://togogenome.org/gene/9646:INHA ^@ http://purl.uniprot.org/uniprot/G1MEP3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.|||Secreted http://togogenome.org/gene/9646:CCNT1 ^@ http://purl.uniprot.org/uniprot/D2HWT3 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9646:TMEM41A ^@ http://purl.uniprot.org/uniprot/D2H294 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM41 family.|||Membrane http://togogenome.org/gene/9646:TM4SF20 ^@ http://purl.uniprot.org/uniprot/D2HCS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9646:RDH16 ^@ http://purl.uniprot.org/uniprot/D2H368 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9646:SULT1B1 ^@ http://purl.uniprot.org/uniprot/D2I2Q5 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9646:ANKRD13C ^@ http://purl.uniprot.org/uniprot/D2I397 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:LOC100475430 ^@ http://purl.uniprot.org/uniprot/G1M060 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:ACTR6 ^@ http://purl.uniprot.org/uniprot/G1M9X8 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9646:RCL1 ^@ http://purl.uniprot.org/uniprot/D2HPJ7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.|||Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.|||nucleolus http://togogenome.org/gene/9646:COQ9 ^@ http://purl.uniprot.org/uniprot/G1MF51 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COQ9 family.|||Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.|||Mitochondrion http://togogenome.org/gene/9646:NFIL3 ^@ http://purl.uniprot.org/uniprot/D2HB66 ^@ Similarity ^@ Belongs to the bZIP family. NFIL3 subfamily. http://togogenome.org/gene/9646:EPO ^@ http://purl.uniprot.org/uniprot/G1M830 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPO/TPO family.|||Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.|||Secreted http://togogenome.org/gene/9646:PHB2 ^@ http://purl.uniprot.org/uniprot/G1M593 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Cell membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9646:MMAB ^@ http://purl.uniprot.org/uniprot/G1MDY1 ^@ Similarity ^@ Belongs to the Cob(I)alamin adenosyltransferase family. http://togogenome.org/gene/9646:PRKCH ^@ http://purl.uniprot.org/uniprot/A0A7N5JK47|||http://purl.uniprot.org/uniprot/G1L8P0 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis.|||Cytoplasm|||Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-513 (activation loop of the kinase domain), Thr-656 (turn motif) and Ser-675 (hydrophobic region), need to be phosphorylated for its full activation. http://togogenome.org/gene/9646:STAC2 ^@ http://purl.uniprot.org/uniprot/D2H530 ^@ Subcellular Location Annotation ^@ sarcolemma http://togogenome.org/gene/9646:WDR83OS ^@ http://purl.uniprot.org/uniprot/D2HG01 ^@ Similarity ^@ Belongs to the Asterix family. http://togogenome.org/gene/9646:CHCHD6 ^@ http://purl.uniprot.org/uniprot/G1LIX6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic25 subfamily.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9646:SEPTIN6 ^@ http://purl.uniprot.org/uniprot/A0A7N5JKF4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9646:IRAK4 ^@ http://purl.uniprot.org/uniprot/G1MG21 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.|||Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.|||Cytoplasm|||Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. http://togogenome.org/gene/9646:SLC35D1 ^@ http://purl.uniprot.org/uniprot/D2HIA6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:EPHA5 ^@ http://purl.uniprot.org/uniprot/A0A7N5K8C7|||http://purl.uniprot.org/uniprot/A0A7N5K9R3|||http://purl.uniprot.org/uniprot/G1LIF2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:FOXN3 ^@ http://purl.uniprot.org/uniprot/G1L490 ^@ Function|||Subcellular Location Annotation ^@ Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).|||Nucleus http://togogenome.org/gene/9646:TUT1 ^@ http://purl.uniprot.org/uniprot/G1LJJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B-like family.|||Nucleus speckle|||nucleolus http://togogenome.org/gene/9646:TM4SF1 ^@ http://purl.uniprot.org/uniprot/G1LX24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9646:CEBPE ^@ http://purl.uniprot.org/uniprot/D2HTW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. C/EBP subfamily.|||Nucleus http://togogenome.org/gene/9646:ERCC4 ^@ http://purl.uniprot.org/uniprot/G1LXW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPF family.|||Nucleus http://togogenome.org/gene/9646:LOC100484315 ^@ http://purl.uniprot.org/uniprot/G1MMT3 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:RNF114 ^@ http://purl.uniprot.org/uniprot/G1M4D3 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.|||Nucleus http://togogenome.org/gene/9646:AGL ^@ http://purl.uniprot.org/uniprot/G1LR84 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycogen debranching enzyme family.|||Cytoplasm|||Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. http://togogenome.org/gene/9646:PPIF ^@ http://purl.uniprot.org/uniprot/D2HJF4 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9646:TIMM8A ^@ http://purl.uniprot.org/uniprot/D2I0C2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9646:LOC100475268 ^@ http://purl.uniprot.org/uniprot/G1LET1 ^@ Similarity ^@ Belongs to the cytochrome c oxidase VIIa family. http://togogenome.org/gene/9646:GSN ^@ http://purl.uniprot.org/uniprot/A0A7N5KBV3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the villin/gelsolin family.|||Binds to actin and to fibronectin. Identified in a complex composed of ACTA1, COBL, GSN and TMSB4X. Interacts with the inactive form of EIF2AK2/PKR.|||Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.|||cytoskeleton http://togogenome.org/gene/9646:DOK6 ^@ http://purl.uniprot.org/uniprot/G1MJ93 ^@ Similarity ^@ Belongs to the DOK family. Type B subfamily. http://togogenome.org/gene/9646:BLOC1S5 ^@ http://purl.uniprot.org/uniprot/G1MG16 ^@ Function|||Similarity ^@ Belongs to the BLOC1S5 family.|||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). http://togogenome.org/gene/9646:LIF ^@ http://purl.uniprot.org/uniprot/A0A7N5JHJ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LIF/OSM family.|||LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.|||Secreted http://togogenome.org/gene/9646:CRHBP ^@ http://purl.uniprot.org/uniprot/A0A7N5JH78|||http://purl.uniprot.org/uniprot/D2HTE8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CRF-binding protein family.|||Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.|||Secreted http://togogenome.org/gene/9646:CHMP5 ^@ http://purl.uniprot.org/uniprot/G1LLT9 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9646:GLRB ^@ http://purl.uniprot.org/uniprot/G1M6Q6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane http://togogenome.org/gene/9646:MAP2K3 ^@ http://purl.uniprot.org/uniprot/G1M0W7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9646:LOC100476812 ^@ http://purl.uniprot.org/uniprot/D2H9N7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9646:PDX1 ^@ http://purl.uniprot.org/uniprot/D2HUX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9646:SCAMP4 ^@ http://purl.uniprot.org/uniprot/G1LF30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/9646:ITPRIPL2 ^@ http://purl.uniprot.org/uniprot/D2HEL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITPRIP family.|||Membrane http://togogenome.org/gene/9646:GAL3ST4 ^@ http://purl.uniprot.org/uniprot/D2HX20 ^@ Similarity ^@ Belongs to the galactose-3-O-sulfotransferase family. http://togogenome.org/gene/9646:RALY ^@ http://purl.uniprot.org/uniprot/G1LR44 ^@ Similarity ^@ Belongs to the RRM HNRPC family. RALY subfamily. http://togogenome.org/gene/9646:UHRF2 ^@ http://purl.uniprot.org/uniprot/D2I1M3 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications.|||Nucleus|||The YDG domain mediates the interaction with histone H3.|||The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3). http://togogenome.org/gene/9646:SNX17 ^@ http://purl.uniprot.org/uniprot/G1L3Y3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane|||Early endosome|||Endosome|||Membrane http://togogenome.org/gene/9646:SNX32 ^@ http://purl.uniprot.org/uniprot/G1MG32 ^@ Function|||Similarity ^@ Belongs to the sorting nexin family.|||Involved in several stages of intracellular trafficking. http://togogenome.org/gene/9646:SNRPB ^@ http://purl.uniprot.org/uniprot/G1LXZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP SmB/SmN family.|||Nucleus http://togogenome.org/gene/9646:CPVL ^@ http://purl.uniprot.org/uniprot/D2GVB0 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/9646:LOC100469977 ^@ http://purl.uniprot.org/uniprot/D2I6S9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:STK4 ^@ http://purl.uniprot.org/uniprot/A0A7N5JI95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Nucleus http://togogenome.org/gene/9646:ATP5MC1 ^@ http://purl.uniprot.org/uniprot/D3JYS0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/9646:AP3B1 ^@ http://purl.uniprot.org/uniprot/D2HE54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes large subunit family.|||Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9646:TVP23B ^@ http://purl.uniprot.org/uniprot/G1LG44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP23 family.|||Membrane http://togogenome.org/gene/9646:GFAP ^@ http://purl.uniprot.org/uniprot/G1MJA2 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9646:LOC100471319 ^@ http://purl.uniprot.org/uniprot/D2HZU2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9646:HSPA5 ^@ http://purl.uniprot.org/uniprot/D2H3W8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 70 family.|||Cell surface|||Endoplasmic reticulum lumen|||Melanosome http://togogenome.org/gene/9646:NFS1 ^@ http://purl.uniprot.org/uniprot/A0A7N5K5N5 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. http://togogenome.org/gene/9646:RNF145 ^@ http://purl.uniprot.org/uniprot/A0A7N5KMS5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:FIP1L1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JWW6|||http://purl.uniprot.org/uniprot/G1LN99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FIP1 family.|||Nucleus http://togogenome.org/gene/9646:EXOC5 ^@ http://purl.uniprot.org/uniprot/G1L6H6 ^@ Similarity ^@ Belongs to the SEC10 family. http://togogenome.org/gene/9646:LOC100464279 ^@ http://purl.uniprot.org/uniprot/G1L6J1 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/9646:SELE ^@ http://purl.uniprot.org/uniprot/G1LXT1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the selectin/LECAM family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:DDX56 ^@ http://purl.uniprot.org/uniprot/G1MH81 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9646:LOC100465782 ^@ http://purl.uniprot.org/uniprot/G1MNU1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:RAD50 ^@ http://purl.uniprot.org/uniprot/G1MH82 ^@ Similarity ^@ Belongs to the SMC family. RAD50 subfamily. http://togogenome.org/gene/9646:CDIPT ^@ http://purl.uniprot.org/uniprot/D2HX36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/9646:SLC13A3 ^@ http://purl.uniprot.org/uniprot/G1KZG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/9646:COQ10B ^@ http://purl.uniprot.org/uniprot/G1M5C4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the COQ10 family.|||Interacts with coenzyme Q.|||Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. http://togogenome.org/gene/9646:TMEM170B ^@ http://purl.uniprot.org/uniprot/D2H2W3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM170 family.|||Membrane http://togogenome.org/gene/9646:PDHX ^@ http://purl.uniprot.org/uniprot/D2HF00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Mitochondrion matrix http://togogenome.org/gene/9646:METTL14 ^@ http://purl.uniprot.org/uniprot/A0A7N5KLA3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MT-A70-like family.|||Heterodimer; heterodimerizes with METTL3 to form an antiparallel heterodimer that constitutes an active methyltransferase.|||Nucleus|||The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation. In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization. M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis. M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells. http://togogenome.org/gene/9646:PIH1D2 ^@ http://purl.uniprot.org/uniprot/D2HG82 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/9646:C12H19orf54 ^@ http://purl.uniprot.org/uniprot/D2HMV0 ^@ Similarity ^@ Belongs to the ACTMAP family. http://togogenome.org/gene/9646:PELO ^@ http://purl.uniprot.org/uniprot/D2HHD0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, pelo recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel.|||Cytoplasm http://togogenome.org/gene/9646:DGKE ^@ http://purl.uniprot.org/uniprot/G1L7T6 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/9646:ELSPBP1 ^@ http://purl.uniprot.org/uniprot/G1M9H3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:TRUB2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JY12 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/9646:CLCN6 ^@ http://purl.uniprot.org/uniprot/G1LTG6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:TIMM22 ^@ http://purl.uniprot.org/uniprot/G1LAL8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM22 complex.|||Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9646:NME5 ^@ http://purl.uniprot.org/uniprot/D2HK89 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9646:SERPINB9 ^@ http://purl.uniprot.org/uniprot/D2I4F0 ^@ Similarity ^@ Belongs to the serpin family. Ov-serpin subfamily. http://togogenome.org/gene/9646:LOC100480908 ^@ http://purl.uniprot.org/uniprot/G1L7T7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. BCS1 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9646:SLC24A3 ^@ http://purl.uniprot.org/uniprot/G1L049 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/9646:GCLC ^@ http://purl.uniprot.org/uniprot/D2HKW5 ^@ Similarity ^@ Belongs to the glutamate--cysteine ligase type 3 family. http://togogenome.org/gene/9646:TPRKB ^@ http://purl.uniprot.org/uniprot/G1MGB1 ^@ Similarity ^@ Belongs to the CGI121/TPRKB family. http://togogenome.org/gene/9646:FOXS1 ^@ http://purl.uniprot.org/uniprot/D2H912 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:RARG ^@ http://purl.uniprot.org/uniprot/G1M0X6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9646:TAF5L ^@ http://purl.uniprot.org/uniprot/D2HHC8 ^@ Similarity ^@ Belongs to the WD repeat TAF5 family. http://togogenome.org/gene/9646:PCSK5 ^@ http://purl.uniprot.org/uniprot/A0A7N5J982 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9646:STT3A ^@ http://purl.uniprot.org/uniprot/G1L2J2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/9646:PPP2R5C ^@ http://purl.uniprot.org/uniprot/A0A7N5KN42 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9646:ABCA12 ^@ http://purl.uniprot.org/uniprot/G1LAR5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:DCLRE1B ^@ http://purl.uniprot.org/uniprot/G1L970 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/9646:LOC100475000 ^@ http://purl.uniprot.org/uniprot/G1M427 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:HIKESHI ^@ http://purl.uniprot.org/uniprot/G1LQD8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.|||Belongs to the OPI10 family.|||Cytoplasm|||Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.|||Nucleus|||cytosol http://togogenome.org/gene/9646:KIF22 ^@ http://purl.uniprot.org/uniprot/G1M8H7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9646:OST4 ^@ http://purl.uniprot.org/uniprot/D2GXM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:JUP ^@ http://purl.uniprot.org/uniprot/D2HIR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-catenin family.|||adherens junction http://togogenome.org/gene/9646:C4BPB ^@ http://purl.uniprot.org/uniprot/G1L9X7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:LOC100476547 ^@ http://purl.uniprot.org/uniprot/G1LCG5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:TFDP2 ^@ http://purl.uniprot.org/uniprot/A0A7N5K2J9|||http://purl.uniprot.org/uniprot/G1M1D9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9646:OSBPL1A ^@ http://purl.uniprot.org/uniprot/D2GUU7 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9646:CLDND2 ^@ http://purl.uniprot.org/uniprot/D2HYM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/9646:ANAPC11 ^@ http://purl.uniprot.org/uniprot/G1MGG2 ^@ Similarity ^@ Belongs to the RING-box family. http://togogenome.org/gene/9646:TRIM2 ^@ http://purl.uniprot.org/uniprot/D2GXS7|||http://purl.uniprot.org/uniprot/G1MJG3 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm|||Forms homooligomers (By similarity). Interacts with TRIM3; this interaction reduces TRIM2 activity (By similarity). Interacts with myosin V; myosin V may not be a substrate for ubiquitination. Interacts with NEFL. Interacts with phosphorylated BCL2L11. Interacts with SIRPA (By similarity).|||RING-type zinc finger-dependent and UBE2D1-dependent autoubiquitination.|||The interaction with myosin V is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain containing six blades.|||UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Plays a role in antiviral immunity and limits New World arenavirus infection independently of its ubiquitin ligase activity. http://togogenome.org/gene/9646:GFOD1 ^@ http://purl.uniprot.org/uniprot/D2H792 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. http://togogenome.org/gene/9646:AATF ^@ http://purl.uniprot.org/uniprot/G1M4N3 ^@ Similarity ^@ Belongs to the AATF family. http://togogenome.org/gene/9646:MED13 ^@ http://purl.uniprot.org/uniprot/G1LQ82 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 13 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9646:DDX18 ^@ http://purl.uniprot.org/uniprot/D2HKQ4 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9646:PKMYT1 ^@ http://purl.uniprot.org/uniprot/G1LP64 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9646:RAD23B ^@ http://purl.uniprot.org/uniprot/G1MF30 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAD23 family.|||Cytoplasm|||Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.|||Nucleus http://togogenome.org/gene/9646:RAF1 ^@ http://purl.uniprot.org/uniprot/D2HGN5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. http://togogenome.org/gene/9646:LHB ^@ http://purl.uniprot.org/uniprot/Q8WN18 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit beta family.|||Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.|||Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.|||Secreted http://togogenome.org/gene/9646:RPS6KB2 ^@ http://purl.uniprot.org/uniprot/G1L1X5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9646:BCKDK ^@ http://purl.uniprot.org/uniprot/D2HQM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9646:LOC100472904 ^@ http://purl.uniprot.org/uniprot/D2I8A4 ^@ Similarity ^@ Belongs to the BEX family. http://togogenome.org/gene/9646:YARS1 ^@ http://purl.uniprot.org/uniprot/G1LLU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Nucleus http://togogenome.org/gene/9646:MRPL10 ^@ http://purl.uniprot.org/uniprot/G1LDK3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL10 family. http://togogenome.org/gene/9646:IFNG ^@ http://purl.uniprot.org/uniprot/C8CBV8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II (or gamma) interferon family.|||Homodimer. Interacts with IFNGR1 (via extracellular domain); this interaction promotes IFNGR1 dimerization.|||Secreted|||Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL. Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation. http://togogenome.org/gene/9646:ARL6 ^@ http://purl.uniprot.org/uniprot/G1M4X8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||cilium membrane http://togogenome.org/gene/9646:TAS2R4 ^@ http://purl.uniprot.org/uniprot/D2HHN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9646:YEATS2 ^@ http://purl.uniprot.org/uniprot/D2H2B5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:TMEM263 ^@ http://purl.uniprot.org/uniprot/G1L7M9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM263 family.|||Membrane http://togogenome.org/gene/9646:NOP2 ^@ http://purl.uniprot.org/uniprot/G1M6U2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||nucleolus http://togogenome.org/gene/9646:RPL22L1 ^@ http://purl.uniprot.org/uniprot/G1LDK9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL22 family. http://togogenome.org/gene/9646:HMGB2 ^@ http://purl.uniprot.org/uniprot/D2GUW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/9646:PDLIM3 ^@ http://purl.uniprot.org/uniprot/A0A7N5K265|||http://purl.uniprot.org/uniprot/D2HM24 ^@ Subcellular Location Annotation ^@ Z line http://togogenome.org/gene/9646:DLX3 ^@ http://purl.uniprot.org/uniprot/D2HMY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus http://togogenome.org/gene/9646:BPGM ^@ http://purl.uniprot.org/uniprot/G1MCI3 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/9646:PPOX ^@ http://purl.uniprot.org/uniprot/D2I0T3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.|||Binds 1 FAD per subunit.|||Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:PFDN5 ^@ http://purl.uniprot.org/uniprot/A0A7N5P899 ^@ Similarity ^@ Belongs to the prefoldin subunit alpha family. http://togogenome.org/gene/9646:GJB4 ^@ http://purl.uniprot.org/uniprot/D2H620 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9646:MAPKAPK3 ^@ http://purl.uniprot.org/uniprot/D2HER6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9646:CCT6B ^@ http://purl.uniprot.org/uniprot/G1M7G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9646:SSTR1 ^@ http://purl.uniprot.org/uniprot/D2HTA1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:ELOA ^@ http://purl.uniprot.org/uniprot/G1LT22 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:IZUMO1R ^@ http://purl.uniprot.org/uniprot/G1LZN7 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/9646:MAPK14 ^@ http://purl.uniprot.org/uniprot/A0A7N5JK52|||http://purl.uniprot.org/uniprot/A0A7N5KIZ5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9646:DPP3 ^@ http://purl.uniprot.org/uniprot/D2HYB0 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M49 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9646:RELL2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JG68 ^@ Similarity ^@ Belongs to the RELT family. http://togogenome.org/gene/9646:FAM160A1 ^@ http://purl.uniprot.org/uniprot/G1MJF1 ^@ Similarity ^@ Belongs to the FHIP family. http://togogenome.org/gene/9646:NDUFB5 ^@ http://purl.uniprot.org/uniprot/D2GUD6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB5 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:TMEM242 ^@ http://purl.uniprot.org/uniprot/G1LSZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM242 family.|||Membrane http://togogenome.org/gene/9646:FAM136A ^@ http://purl.uniprot.org/uniprot/D2H0E1 ^@ Similarity ^@ Belongs to the FAM136 family. http://togogenome.org/gene/9646:LOC100472448 ^@ http://purl.uniprot.org/uniprot/D2HU48 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:TRPV6 ^@ http://purl.uniprot.org/uniprot/D2HP39 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9646:ITGB8 ^@ http://purl.uniprot.org/uniprot/D2H1I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Melanosome|||Membrane|||Recycling endosome|||focal adhesion|||invadopodium membrane|||lamellipodium|||ruffle membrane http://togogenome.org/gene/9646:SHROOM3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JZR7|||http://purl.uniprot.org/uniprot/G1LZB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shroom family.|||cytoskeleton http://togogenome.org/gene/9646:SYNCRIP ^@ http://purl.uniprot.org/uniprot/D2HLE8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:PIGL ^@ http://purl.uniprot.org/uniprot/A0A7N5K667|||http://purl.uniprot.org/uniprot/D2HFN9 ^@ Function|||Similarity ^@ Belongs to the PIGL family.|||Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol. http://togogenome.org/gene/9646:MORF4L2 ^@ http://purl.uniprot.org/uniprot/D2HTN4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:CNGA4 ^@ http://purl.uniprot.org/uniprot/D2HR69 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:PAX9 ^@ http://purl.uniprot.org/uniprot/G1L841 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:WASHC5 ^@ http://purl.uniprot.org/uniprot/A0A7N5JFD5|||http://purl.uniprot.org/uniprot/G1L0H7 ^@ Similarity ^@ Belongs to the strumpellin family. http://togogenome.org/gene/9646:GSC ^@ http://purl.uniprot.org/uniprot/D2HEN0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:MINAR2 ^@ http://purl.uniprot.org/uniprot/G1LDS6 ^@ Similarity ^@ Belongs to the MINAR family. http://togogenome.org/gene/9646:INTS10 ^@ http://purl.uniprot.org/uniprot/A0A7N5P5F5|||http://purl.uniprot.org/uniprot/G1LDX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 10 family.|||Nucleus http://togogenome.org/gene/9646:LOC100475582 ^@ http://purl.uniprot.org/uniprot/A0A7N5JHP7|||http://purl.uniprot.org/uniprot/D2HQM1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Inflammasome http://togogenome.org/gene/9646:DCT ^@ http://purl.uniprot.org/uniprot/D2H9Z1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane http://togogenome.org/gene/9646:OTX2 ^@ http://purl.uniprot.org/uniprot/D2GVQ2|||http://purl.uniprot.org/uniprot/G1L6C5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9646:LOC100477514 ^@ http://purl.uniprot.org/uniprot/D2I465 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:MED8 ^@ http://purl.uniprot.org/uniprot/G1L470 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 8 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9646:WDR48 ^@ http://purl.uniprot.org/uniprot/G1L2W5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR48 family.|||Late endosome http://togogenome.org/gene/9646:RDX ^@ http://purl.uniprot.org/uniprot/A0A7N5J969 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton|||microvillus http://togogenome.org/gene/9646:BRIX1 ^@ http://purl.uniprot.org/uniprot/D2HC18 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BRX1 family.|||Required for biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/9646:C13H20orf27 ^@ http://purl.uniprot.org/uniprot/A0A7N5JRV7 ^@ Similarity ^@ Belongs to the ADISSP family. http://togogenome.org/gene/9646:FYN ^@ http://purl.uniprot.org/uniprot/A0A7N5JD06|||http://purl.uniprot.org/uniprot/A0A7N5JN10|||http://purl.uniprot.org/uniprot/D2H640 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane http://togogenome.org/gene/9646:PARL ^@ http://purl.uniprot.org/uniprot/D2H2B4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:PSMB8 ^@ http://purl.uniprot.org/uniprot/D2GZ14 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:C16H11orf94 ^@ http://purl.uniprot.org/uniprot/D2HJ50 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Endoplasmic reticulum membrane|||Interacts with SPPL2C (via active sites); the interaction stabilizes FREY1 protein and inhibits SPPL2C proteolytic activity. Interacts with IZUMO1; the interaction retains IZUMO1 at the endoplasmic reticulum membrane and coordinates IZUMO1 complex assembly.|||Key regulator for male fertility expressed transiently in round spermatids where it recruits IZUMO1 at the endoplasmic reticulum (ER) membrane and coordinates the oolemmal binding multimeric complex (IZUMO1 complex) assembly. Upon complete assembly of the IZUMO1 complex, its ER retention is released, facilitating IZUMO1 complex export to the acrosome. Through the interaction with SPPL2C, inhibits its intramembrane protease activity directly accessing the catalytic center of an I-CLiP. http://togogenome.org/gene/9646:FABP5 ^@ http://purl.uniprot.org/uniprot/J7FAN4 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9646:CCDC85B ^@ http://purl.uniprot.org/uniprot/D2H4N9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC85 family.|||adherens junction http://togogenome.org/gene/9646:MRPS11 ^@ http://purl.uniprot.org/uniprot/G1M295 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/9646:NPC2 ^@ http://purl.uniprot.org/uniprot/A0A7N5K6P7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPC2 family.|||Secreted http://togogenome.org/gene/9646:GDPD3 ^@ http://purl.uniprot.org/uniprot/D2HX49|||http://purl.uniprot.org/uniprot/G1M9U8 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9646:CX3CR1 ^@ http://purl.uniprot.org/uniprot/G1LQR4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1.|||Membrane http://togogenome.org/gene/9646:AP1G2 ^@ http://purl.uniprot.org/uniprot/D2HG65 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/9646:LOC100465086 ^@ http://purl.uniprot.org/uniprot/D2HI19 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:ATF2 ^@ http://purl.uniprot.org/uniprot/A0A7N5K1Y0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bZIP family.|||Binds DNA as a dimer and can form a homodimer in the absence of DNA.|||Nucleus|||Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). http://togogenome.org/gene/9646:SLC11A2 ^@ http://purl.uniprot.org/uniprot/G1L645 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NRAMP family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Macrophage-specific antiporter that fluxes metal ions in either direction against a proton gradient. Localized to late endosomal lysosomal membranes, delivers bivalent cations from the cytosol into these acidic compartments where they may directly affect antimicrobial activity. Involved in iron metabolism and host natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes. http://togogenome.org/gene/9646:WFIKKN2 ^@ http://purl.uniprot.org/uniprot/D2HTT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WFIKKN family.|||Secreted http://togogenome.org/gene/9646:ESCO1 ^@ http://purl.uniprot.org/uniprot/D2HZR2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:ATAD1 ^@ http://purl.uniprot.org/uniprot/A0A7N5P0A3 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9646:SMIM7 ^@ http://purl.uniprot.org/uniprot/A0A7N5JLY3 ^@ Similarity ^@ Belongs to the SMIM7 family. http://togogenome.org/gene/9646:ENY2 ^@ http://purl.uniprot.org/uniprot/A0A7N5K0V2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ENY2 family.|||Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.|||Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.|||nucleoplasm http://togogenome.org/gene/9646:BLOC1S2 ^@ http://purl.uniprot.org/uniprot/G1LJR2 ^@ Similarity ^@ Belongs to the BLOC1S2 family. http://togogenome.org/gene/9646:TYRO3 ^@ http://purl.uniprot.org/uniprot/A0A7N5P830 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.|||Membrane http://togogenome.org/gene/9646:IL7 ^@ http://purl.uniprot.org/uniprot/G1LMV3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-7/IL-9 family.|||Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis.|||Secreted http://togogenome.org/gene/9646:MGRN1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JKM0|||http://purl.uniprot.org/uniprot/A0A7N5KAF8|||http://purl.uniprot.org/uniprot/A0A7N5KFA3 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin ligase. http://togogenome.org/gene/9646:NEK9 ^@ http://purl.uniprot.org/uniprot/D2GZX8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. http://togogenome.org/gene/9646:DLX4 ^@ http://purl.uniprot.org/uniprot/D2HMY2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:ARRDC5 ^@ http://purl.uniprot.org/uniprot/D2I2H1 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9646:TIGD6 ^@ http://purl.uniprot.org/uniprot/D2H8M5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:TMOD2 ^@ http://purl.uniprot.org/uniprot/G1LRW5 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9646:EIF3G ^@ http://purl.uniprot.org/uniprot/G1LZU6 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit G family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of FRAP1 and RAPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts (via C-terminus) with AIFM1 (via N-terminus).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Phosphorylated. Phosphorylation is enhanced upon serum stimulation.|||RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA.|||perinuclear region http://togogenome.org/gene/9646:LOC100479766 ^@ http://purl.uniprot.org/uniprot/A0A7N5P672 ^@ Similarity ^@ Belongs to the TAF9 family. CENP-S/MHF1 subfamily. http://togogenome.org/gene/9646:LIN28A ^@ http://purl.uniprot.org/uniprot/D2GWG9 ^@ Similarity ^@ Belongs to the lin-28 family. http://togogenome.org/gene/9646:RNF141 ^@ http://purl.uniprot.org/uniprot/D2H3H2 ^@ Function ^@ May be involved in spermatogenesis. http://togogenome.org/gene/9646:TIMM17B ^@ http://purl.uniprot.org/uniprot/A0A7N5P4H4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9646:GATM ^@ http://purl.uniprot.org/uniprot/G1M1W7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the amidinotransferase family.|||Homodimer.|||Mitochondrion inner membrane|||Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives. Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain. http://togogenome.org/gene/9646:PDIA3 ^@ http://purl.uniprot.org/uniprot/D2GW48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9646:LOC100476462 ^@ http://purl.uniprot.org/uniprot/A0A7N5KIH8|||http://purl.uniprot.org/uniprot/G1MKE6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9646:FGF17 ^@ http://purl.uniprot.org/uniprot/G1LA01 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9646:TEKT3 ^@ http://purl.uniprot.org/uniprot/G1LG05 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/9646:LOC100481490 ^@ http://purl.uniprot.org/uniprot/G1ML99 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCO1/2 family.|||Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2.|||Homodimer.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:LOC100471215 ^@ http://purl.uniprot.org/uniprot/D2HU38 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:CHMP2B ^@ http://purl.uniprot.org/uniprot/G1LL36 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9646:LOC100468297 ^@ http://purl.uniprot.org/uniprot/A0A7N5KF74 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9646:GPR34 ^@ http://purl.uniprot.org/uniprot/G1MMN0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Orphan receptor. http://togogenome.org/gene/9646:FOXN4 ^@ http://purl.uniprot.org/uniprot/D2HGL5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:TMEM267 ^@ http://purl.uniprot.org/uniprot/D2HHR2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:NIP7 ^@ http://purl.uniprot.org/uniprot/D2HLI3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NIP7 family.|||Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.|||nucleolus http://togogenome.org/gene/9646:B3GNT9 ^@ http://purl.uniprot.org/uniprot/A0A7N5P783 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:LOC100483898 ^@ http://purl.uniprot.org/uniprot/G1L7C6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Membrane|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. http://togogenome.org/gene/9646:CUL2 ^@ http://purl.uniprot.org/uniprot/D2HSC2 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9646:LOC100479522 ^@ http://purl.uniprot.org/uniprot/G1L2V2 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/9646:FAM183A ^@ http://purl.uniprot.org/uniprot/G1L4S8 ^@ Similarity ^@ Belongs to the CFAP144 family. http://togogenome.org/gene/9646:LOC100471057 ^@ http://purl.uniprot.org/uniprot/G1L971 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:FGF6 ^@ http://purl.uniprot.org/uniprot/D2HEJ8 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9646:SMCO2 ^@ http://purl.uniprot.org/uniprot/G1LYP6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:TUBA8 ^@ http://purl.uniprot.org/uniprot/G1MGF0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9646:CDC42EP4 ^@ http://purl.uniprot.org/uniprot/D2HUC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/9646:RBPJ ^@ http://purl.uniprot.org/uniprot/G1MIC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Su(H) family.|||Nucleus http://togogenome.org/gene/9646:MON2 ^@ http://purl.uniprot.org/uniprot/D2HCH6|||http://purl.uniprot.org/uniprot/G1LTJ1 ^@ Similarity ^@ Belongs to the MON2 family. http://togogenome.org/gene/9646:GSTCD ^@ http://purl.uniprot.org/uniprot/D2HPF3 ^@ Similarity ^@ Belongs to the GSTCD family. http://togogenome.org/gene/9646:TBCCD1 ^@ http://purl.uniprot.org/uniprot/D2H077 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBCC family.|||centrosome|||spindle pole http://togogenome.org/gene/9646:KARS1 ^@ http://purl.uniprot.org/uniprot/D2HY20|||http://purl.uniprot.org/uniprot/G1LFN2 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9646:ACAD8 ^@ http://purl.uniprot.org/uniprot/A0A7N5JHS6 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9646:BPIFC ^@ http://purl.uniprot.org/uniprot/D2HHA9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.|||Monomer. Homodimer; disulfide-linked.|||Secreted|||The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.|||The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.|||The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. http://togogenome.org/gene/9646:FIGN ^@ http://purl.uniprot.org/uniprot/G1M6V6 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9646:ETS1 ^@ http://purl.uniprot.org/uniprot/G1L7C9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:XPNPEP1 ^@ http://purl.uniprot.org/uniprot/D2HRH3 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/9646:SERPINB10 ^@ http://purl.uniprot.org/uniprot/D2HUS9 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9646:RNASE1 ^@ http://purl.uniprot.org/uniprot/D2HYD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pancreatic ribonuclease family.|||Secreted http://togogenome.org/gene/9646:PPIP5K2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JFW0|||http://purl.uniprot.org/uniprot/A0A7N5KC29|||http://purl.uniprot.org/uniprot/A0A7N5KLD3|||http://purl.uniprot.org/uniprot/G1MET4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histidine acid phosphatase family. VIP1 subfamily.|||Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).|||cytosol http://togogenome.org/gene/9646:CLDN1 ^@ http://purl.uniprot.org/uniprot/D2H059 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9646:PHF20L1 ^@ http://purl.uniprot.org/uniprot/G1M2M1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:LOC100484314 ^@ http://purl.uniprot.org/uniprot/A0A7N5KEB3|||http://purl.uniprot.org/uniprot/D2I587 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OXA1/ALB3/YidC family.|||Membrane http://togogenome.org/gene/9646:EHHADH ^@ http://purl.uniprot.org/uniprot/G1MEK3 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9646:FUNDC1 ^@ http://purl.uniprot.org/uniprot/G1LUN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FUN14 family.|||Mitochondrion outer membrane http://togogenome.org/gene/9646:GRIK1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KDP5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9646:TET1 ^@ http://purl.uniprot.org/uniprot/D2GXI8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TET family.|||Binds 1 Fe(2+) ion per subunit.|||Chromosome|||Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.|||The zinc ions have a structural role. http://togogenome.org/gene/9646:ATP5IF1 ^@ http://purl.uniprot.org/uniprot/A0A7N5P989 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase inhibitor family.|||Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.|||Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.|||Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.|||Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.|||Mitochondrion http://togogenome.org/gene/9646:PCID2 ^@ http://purl.uniprot.org/uniprot/G1LUL1 ^@ Similarity ^@ Belongs to the CSN12 family. http://togogenome.org/gene/9646:IER2 ^@ http://purl.uniprot.org/uniprot/D2HG26 ^@ Similarity ^@ Belongs to the IER family. http://togogenome.org/gene/9646:FAM133A ^@ http://purl.uniprot.org/uniprot/G1MLF6 ^@ Similarity ^@ Belongs to the FAM133 family. http://togogenome.org/gene/9646:BMP4 ^@ http://purl.uniprot.org/uniprot/D2HCK9 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9646:ASF1A ^@ http://purl.uniprot.org/uniprot/G1LA84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/9646:PDCD5 ^@ http://purl.uniprot.org/uniprot/D2H3A5 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/9646:CPB1 ^@ http://purl.uniprot.org/uniprot/D2HWE0 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9646:MAPK10 ^@ http://purl.uniprot.org/uniprot/A0A7N5KBI2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/9646:IGF2BP1 ^@ http://purl.uniprot.org/uniprot/D2H577 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM IMP/VICKZ family.|||Nucleus|||P-body|||Stress granule|||filopodium|||growth cone|||lamellipodium|||perinuclear region http://togogenome.org/gene/9646:DAD1 ^@ http://purl.uniprot.org/uniprot/D2HTV2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DAD/OST2 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/9646:CCSER2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JAB1|||http://purl.uniprot.org/uniprot/D2H1J3 ^@ Similarity ^@ Belongs to the CCSER family. http://togogenome.org/gene/9646:JPT2 ^@ http://purl.uniprot.org/uniprot/G1LNM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:METAP1 ^@ http://purl.uniprot.org/uniprot/G1M5Q5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/9646:CCR8 ^@ http://purl.uniprot.org/uniprot/D2HZM8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:ACTL9 ^@ http://purl.uniprot.org/uniprot/D2HZT2 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9646:AGA ^@ http://purl.uniprot.org/uniprot/G1LAI5 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/9646:MMP20 ^@ http://purl.uniprot.org/uniprot/D2HIG8 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9646:USP33 ^@ http://purl.uniprot.org/uniprot/A0A7N5JNV9|||http://purl.uniprot.org/uniprot/G1LL63 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family. USP20/USP33 subfamily.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||centrosome|||perinuclear region http://togogenome.org/gene/9646:CXCL10 ^@ http://purl.uniprot.org/uniprot/A0A7N5JM26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9646:CTPS1 ^@ http://purl.uniprot.org/uniprot/D2I190 ^@ Function|||Similarity ^@ Belongs to the CTP synthase family.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. http://togogenome.org/gene/9646:MINAR1 ^@ http://purl.uniprot.org/uniprot/D2HL04 ^@ Similarity ^@ Belongs to the MINAR family. http://togogenome.org/gene/9646:ATOH7 ^@ http://purl.uniprot.org/uniprot/D2GXJ4 ^@ Subcellular Location Annotation ^@ Nucleus|||Perikaryon|||axon http://togogenome.org/gene/9646:GGT5 ^@ http://purl.uniprot.org/uniprot/G1M5J8 ^@ Similarity ^@ Belongs to the gamma-glutamyltransferase family. http://togogenome.org/gene/9646:LAPTM5 ^@ http://purl.uniprot.org/uniprot/D2HNI0 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/9646:TDRD7 ^@ http://purl.uniprot.org/uniprot/G1LE45 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TDRD7 family.|||Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.|||Cytoplasm|||Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex containing CABLES1, CDK16 and CDK17. Interacts with CABLES1, CDK17 and PIWIL1. http://togogenome.org/gene/9646:POLR2J ^@ http://purl.uniprot.org/uniprot/G1MAF0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.|||Nucleus http://togogenome.org/gene/9646:FAM199X ^@ http://purl.uniprot.org/uniprot/D2I4E6 ^@ Similarity ^@ Belongs to the FAM199 family. http://togogenome.org/gene/9646:AK4 ^@ http://purl.uniprot.org/uniprot/D2HQE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylate kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9646:G6PC ^@ http://purl.uniprot.org/uniprot/D2I4E4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9646:DAPK2 ^@ http://purl.uniprot.org/uniprot/G1L6P1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9646:TOR2A ^@ http://purl.uniprot.org/uniprot/D2H3Y9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ClpA/ClpB family. Torsin subfamily.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9646:DPCD ^@ http://purl.uniprot.org/uniprot/G1MGY5 ^@ Similarity ^@ Belongs to the DPCD family. http://togogenome.org/gene/9646:IL4 ^@ http://purl.uniprot.org/uniprot/Q3S4V6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-4/IL-13 family.|||Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.|||Secreted http://togogenome.org/gene/9646:TMEM168 ^@ http://purl.uniprot.org/uniprot/D2H0S2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM168 family.|||Membrane|||Nucleus membrane http://togogenome.org/gene/9646:SLC25A44 ^@ http://purl.uniprot.org/uniprot/D2HW65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9646:MAT2A ^@ http://purl.uniprot.org/uniprot/A0A7N5JA28 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/9646:TAF9 ^@ http://purl.uniprot.org/uniprot/D2H2U2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF9 family.|||Nucleus http://togogenome.org/gene/9646:TGM1 ^@ http://purl.uniprot.org/uniprot/D2HG44 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9646:CPNE2 ^@ http://purl.uniprot.org/uniprot/D2GTW4 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9646:POLR3K ^@ http://purl.uniprot.org/uniprot/D2HDU8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||nucleolus http://togogenome.org/gene/9646:IER3IP1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JM38 ^@ Similarity ^@ Belongs to the YOS1 family. http://togogenome.org/gene/9646:LOC100478515 ^@ http://purl.uniprot.org/uniprot/A0A7N5K3U2 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9646:SMG1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KD81 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. http://togogenome.org/gene/9646:LOC105241292 ^@ http://purl.uniprot.org/uniprot/A0A7N5JJA2 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9646:PITX3 ^@ http://purl.uniprot.org/uniprot/G1MH59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9646:RAB3C ^@ http://purl.uniprot.org/uniprot/A0A7N5JWR6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/9646:AP3M2 ^@ http://purl.uniprot.org/uniprot/D2H984 ^@ Similarity ^@ Belongs to the adaptor complexes medium subunit family. http://togogenome.org/gene/9646:S100G ^@ http://purl.uniprot.org/uniprot/D2HDU5 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9646:STRADB ^@ http://purl.uniprot.org/uniprot/A0A7N5P4Q9|||http://purl.uniprot.org/uniprot/G1LHX1 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. http://togogenome.org/gene/9646:SLU7 ^@ http://purl.uniprot.org/uniprot/D2GUJ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the SLU7 family.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/9646:LOC100478655 ^@ http://purl.uniprot.org/uniprot/G1LR62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.|||cytoskeleton http://togogenome.org/gene/9646:RFX6 ^@ http://purl.uniprot.org/uniprot/D2HNW6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RFX family.|||Interacts with RFX3.|||Nucleus|||Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes. Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription. http://togogenome.org/gene/9646:OPRL1 ^@ http://purl.uniprot.org/uniprot/D2HT41 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasmic vesicle|||G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.|||Membrane|||Vesicle http://togogenome.org/gene/9646:PPP1R1C ^@ http://purl.uniprot.org/uniprot/A0A7N5P8Q1|||http://purl.uniprot.org/uniprot/G1L8T1 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 1 family. http://togogenome.org/gene/9646:LOC100463617 ^@ http://purl.uniprot.org/uniprot/G1MM28 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9646:DBX1 ^@ http://purl.uniprot.org/uniprot/G1LDD2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:PIK3IP1 ^@ http://purl.uniprot.org/uniprot/G1LKJ6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:TIPRL ^@ http://purl.uniprot.org/uniprot/D2I6H5 ^@ Similarity ^@ Belongs to the TIP41 family. http://togogenome.org/gene/9646:ATE1 ^@ http://purl.uniprot.org/uniprot/G1LWQ0 ^@ Function|||Similarity ^@ Belongs to the R-transferase family.|||Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. http://togogenome.org/gene/9646:LOC100478374 ^@ http://purl.uniprot.org/uniprot/D2I4Z7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:LOC100476759 ^@ http://purl.uniprot.org/uniprot/G1L0V5 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9646:TENT5D ^@ http://purl.uniprot.org/uniprot/G1MKZ1 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/9646:RPL37A ^@ http://purl.uniprot.org/uniprot/A0A7N5JEV2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL43 family. http://togogenome.org/gene/9646:WASF3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JJI1|||http://purl.uniprot.org/uniprot/D2HP85 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCAR/WAVE family.|||Binds actin and the Arp2/3 complex.|||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|||cytoskeleton http://togogenome.org/gene/9646:TXNL4B ^@ http://purl.uniprot.org/uniprot/D2HMK1 ^@ Similarity ^@ Belongs to the DIM1 family. http://togogenome.org/gene/9646:LOC109489374 ^@ http://purl.uniprot.org/uniprot/A0A7N5JF78 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9646:DRD2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JMU2|||http://purl.uniprot.org/uniprot/G1LHT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:LOC100478779 ^@ http://purl.uniprot.org/uniprot/D2I473 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:S1PR1 ^@ http://purl.uniprot.org/uniprot/D2HAQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:PRKACB ^@ http://purl.uniprot.org/uniprot/A0A7N5JV97|||http://purl.uniprot.org/uniprot/A0A7N5P3U8|||http://purl.uniprot.org/uniprot/D2HVX2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/9646:GC ^@ http://purl.uniprot.org/uniprot/G1LHM6 ^@ Function|||Subcellular Location Annotation ^@ Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.|||Secreted http://togogenome.org/gene/9646:ACTL6A ^@ http://purl.uniprot.org/uniprot/G1LWH1 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9646:PPP1R12A ^@ http://purl.uniprot.org/uniprot/A0A7N5P5R6|||http://purl.uniprot.org/uniprot/G1M406 ^@ Subcellular Location Annotation|||Subunit ^@ PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.|||stress fiber http://togogenome.org/gene/9646:SF3B6 ^@ http://purl.uniprot.org/uniprot/G1L7R7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:KEG54_p08 ^@ http://purl.uniprot.org/uniprot/A5JFK1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase A chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with DNAJC30; interaction is direct.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:PRUNE1 ^@ http://purl.uniprot.org/uniprot/G1L2J9 ^@ Similarity ^@ Belongs to the PPase class C family. Prune subfamily. http://togogenome.org/gene/9646:SND1 ^@ http://purl.uniprot.org/uniprot/G1LDP5 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. http://togogenome.org/gene/9646:PISD ^@ http://purl.uniprot.org/uniprot/A0A7N5K2N2 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.|||Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:KCNA2 ^@ http://purl.uniprot.org/uniprot/D2HZL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.|||Cell membrane|||Membrane|||Presynaptic cell membrane|||Synaptic cell membrane|||lamellipodium membrane|||paranodal septate junction|||synaptosome http://togogenome.org/gene/9646:POU1F1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KPA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/9646:CPLANE2 ^@ http://purl.uniprot.org/uniprot/G1LYM1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.|||cilium basal body http://togogenome.org/gene/9646:NTMT1 ^@ http://purl.uniprot.org/uniprot/D2H163 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. NTM1 family.|||Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation. Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.|||Nucleus http://togogenome.org/gene/9646:YPEL3 ^@ http://purl.uniprot.org/uniprot/G1M9S6 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9646:IAPP ^@ http://purl.uniprot.org/uniprot/G1L224 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calcitonin family.|||Secreted|||Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. http://togogenome.org/gene/9646:GLS2 ^@ http://purl.uniprot.org/uniprot/D2H360 ^@ Similarity ^@ Belongs to the glutaminase family. http://togogenome.org/gene/9646:DNMT3B ^@ http://purl.uniprot.org/uniprot/G1M3V4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.|||Nucleus http://togogenome.org/gene/9646:PDE4B ^@ http://purl.uniprot.org/uniprot/A0A7N5P511|||http://purl.uniprot.org/uniprot/G1MI93 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9646:OIP5 ^@ http://purl.uniprot.org/uniprot/A0A7N5K262 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.|||centromere http://togogenome.org/gene/9646:SLC2A12 ^@ http://purl.uniprot.org/uniprot/A0A7N5JNF4|||http://purl.uniprot.org/uniprot/D2HJ42 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. http://togogenome.org/gene/9646:FAM124B ^@ http://purl.uniprot.org/uniprot/D2H9R1 ^@ Similarity ^@ Belongs to the FAM124 family. http://togogenome.org/gene/9646:LOC100474256 ^@ http://purl.uniprot.org/uniprot/D2I7D4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:ING2 ^@ http://purl.uniprot.org/uniprot/D2GY56 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9646:GLMP ^@ http://purl.uniprot.org/uniprot/D2HW69 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GLMP family.|||Interacts (via lumenal domain) with lysosomal protein MFSD1; the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stability and lysosomal localization of MFSD1.|||Lysosome membrane|||Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization. http://togogenome.org/gene/9646:EGFL7 ^@ http://purl.uniprot.org/uniprot/G1LB99 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:FASLG ^@ http://purl.uniprot.org/uniprot/D2H5H5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tumor necrosis factor family.|||Cell membrane|||Cytoplasmic form induces gene transcription inhibition.|||Cytoplasmic vesicle lumen|||Lysosome lumen|||Nucleus|||Secreted http://togogenome.org/gene/9646:CPN1 ^@ http://purl.uniprot.org/uniprot/G1LKA1 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9646:NDUFV3 ^@ http://purl.uniprot.org/uniprot/G1L4V0 ^@ Function|||Similarity|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.|||Belongs to the complex I NDUFV3 subunit family.|||Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme. http://togogenome.org/gene/9646:SLC35E1 ^@ http://purl.uniprot.org/uniprot/D2GUZ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:KCNS3 ^@ http://purl.uniprot.org/uniprot/D2H0L8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:MCM2 ^@ http://purl.uniprot.org/uniprot/G1M927 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Chromosome|||Nucleus http://togogenome.org/gene/9646:KCNJ2 ^@ http://purl.uniprot.org/uniprot/D2HP90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.|||Membrane http://togogenome.org/gene/9646:PRICKLE2 ^@ http://purl.uniprot.org/uniprot/D2HL65 ^@ Similarity ^@ Belongs to the prickle / espinas / testin family. http://togogenome.org/gene/9646:CNFN ^@ http://purl.uniprot.org/uniprot/D2HNH5 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/9646:ADGRG6 ^@ http://purl.uniprot.org/uniprot/A0A7N5K657|||http://purl.uniprot.org/uniprot/A0A7N5P249|||http://purl.uniprot.org/uniprot/G1LZ23 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:UBN1 ^@ http://purl.uniprot.org/uniprot/G1L4E5 ^@ Similarity ^@ Belongs to the ubinuclein family. http://togogenome.org/gene/9646:IL17RA ^@ http://purl.uniprot.org/uniprot/A0A7N5KAM7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9646:SSR3 ^@ http://purl.uniprot.org/uniprot/A0A7N5KN28 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-gamma family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/9646:AHDC1 ^@ http://purl.uniprot.org/uniprot/D2GWJ0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:TOB1 ^@ http://purl.uniprot.org/uniprot/D2HTT8 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9646:REV1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JF38|||http://purl.uniprot.org/uniprot/G1M3Q2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-Y family.|||Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.|||Nucleus http://togogenome.org/gene/9646:GRB2 ^@ http://purl.uniprot.org/uniprot/D2HD44 ^@ Subcellular Location Annotation ^@ Endosome|||Golgi apparatus|||Nucleus http://togogenome.org/gene/9646:FOXO4 ^@ http://purl.uniprot.org/uniprot/G1MBP3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:CA13 ^@ http://purl.uniprot.org/uniprot/A0A7N5J9T4 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9646:MAST3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JQ64|||http://purl.uniprot.org/uniprot/A0A7N5JZE1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/9646:LOC100471975 ^@ http://purl.uniprot.org/uniprot/D2I550 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:TRMT13 ^@ http://purl.uniprot.org/uniprot/D2HFE7 ^@ Function|||Similarity ^@ Belongs to the methyltransferase TRM13 family.|||tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His). http://togogenome.org/gene/9646:LZTFL1 ^@ http://purl.uniprot.org/uniprot/G1M0S6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LZTFL1 family.|||Cytoplasm|||Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.|||Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking. http://togogenome.org/gene/9646:ACTG2 ^@ http://purl.uniprot.org/uniprot/D2HH73 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9646:MIOX ^@ http://purl.uniprot.org/uniprot/G1L848 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the myo-inositol oxygenase family.|||Binds 2 iron ions per subunit.|||Cytoplasm http://togogenome.org/gene/9646:LHX2 ^@ http://purl.uniprot.org/uniprot/D2HDG3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:CCL24 ^@ http://purl.uniprot.org/uniprot/A0A7N5JCF2 ^@ Similarity ^@ Belongs to the intercrine beta (chemokine CC) family. http://togogenome.org/gene/9646:RARRES2 ^@ http://purl.uniprot.org/uniprot/D2HN07 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9646:SDR9C7 ^@ http://purl.uniprot.org/uniprot/D2H367 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9646:TIGD2 ^@ http://purl.uniprot.org/uniprot/D2H7I1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:ALPL ^@ http://purl.uniprot.org/uniprot/G1M6R5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alkaline phosphatase family.|||Binds 1 Mg(2+) ion.|||Binds 2 Zn(2+) ions.|||Cell membrane|||Homodimer.|||Membrane http://togogenome.org/gene/9646:PPP2R2B ^@ http://purl.uniprot.org/uniprot/A0A7N5JQK6 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/9646:ACMSD ^@ http://purl.uniprot.org/uniprot/A0A7N5JHJ2|||http://purl.uniprot.org/uniprot/G1MD21 ^@ Function|||Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.|||Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.|||Monomer. http://togogenome.org/gene/9646:LOC100466688 ^@ http://purl.uniprot.org/uniprot/D2HWJ9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9646:PDE5A ^@ http://purl.uniprot.org/uniprot/G1MET3|||http://purl.uniprot.org/uniprot/G1MET6 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9646:SDHC ^@ http://purl.uniprot.org/uniprot/A0A7N5KM32 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.|||Membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). http://togogenome.org/gene/9646:GPAT3 ^@ http://purl.uniprot.org/uniprot/D2GUE1 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9646:OGDHL ^@ http://purl.uniprot.org/uniprot/D2HUG6 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/9646:STX3 ^@ http://purl.uniprot.org/uniprot/A0A7N5P1Y0 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9646:DCTN6 ^@ http://purl.uniprot.org/uniprot/A0A7N5KK74|||http://purl.uniprot.org/uniprot/A0A7N5P636 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.|||Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.|||cytoskeleton http://togogenome.org/gene/9646:OPALIN ^@ http://purl.uniprot.org/uniprot/A0A7N5KJH9 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation.|||Membrane http://togogenome.org/gene/9646:PPP2R2C ^@ http://purl.uniprot.org/uniprot/A0A7N5K665 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/9646:ADCK2 ^@ http://purl.uniprot.org/uniprot/G1MHJ0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family. http://togogenome.org/gene/9646:RSPO3 ^@ http://purl.uniprot.org/uniprot/G1LSB8 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/9646:PODXL ^@ http://purl.uniprot.org/uniprot/G1LGV4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the podocalyxin family.|||Cell membrane|||Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.|||Membrane|||Membrane raft|||filopodium|||lamellipodium|||microvillus|||ruffle http://togogenome.org/gene/9646:TRUB1 ^@ http://purl.uniprot.org/uniprot/G1M8S5 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/9646:SH2D1A ^@ http://purl.uniprot.org/uniprot/D2HJ45 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:UBE2F ^@ http://purl.uniprot.org/uniprot/A0A7N5KAT6|||http://purl.uniprot.org/uniprot/G1LPN3 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9646:LOC100475277 ^@ http://purl.uniprot.org/uniprot/D2I3R1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:LEP ^@ http://purl.uniprot.org/uniprot/A0A7N5P1L2|||http://purl.uniprot.org/uniprot/B0ZE72 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the leptin family.|||Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways. May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells. Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 wich promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38. In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses. Increases CD4(+)CD25(-) T-cell proliferation and reduces autophagy during TCR (T-cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation.|||Secreted http://togogenome.org/gene/9646:CKS1B ^@ http://purl.uniprot.org/uniprot/A0A7N5JH98 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.|||Forms a homohexamer that can probably bind six kinase subunits. http://togogenome.org/gene/9646:CCT2 ^@ http://purl.uniprot.org/uniprot/G1LZI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9646:SLC17A6 ^@ http://purl.uniprot.org/uniprot/D2GY93 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:AK3 ^@ http://purl.uniprot.org/uniprot/D2HPJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylate kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9646:TCN2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JXU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic cobalamin transport proteins family.|||Secreted http://togogenome.org/gene/9646:TNFRSF14 ^@ http://purl.uniprot.org/uniprot/G1M3X9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:RPS23 ^@ http://purl.uniprot.org/uniprot/F2X222 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS12 family.|||Rough endoplasmic reticulum http://togogenome.org/gene/9646:LGMN ^@ http://purl.uniprot.org/uniprot/G1M534 ^@ Similarity ^@ Belongs to the peptidase C13 family. http://togogenome.org/gene/9646:TTC21B ^@ http://purl.uniprot.org/uniprot/G1MB04 ^@ Similarity ^@ Belongs to the TTC21 family. http://togogenome.org/gene/9646:SSR2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JSZ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-beta family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/9646:ZNF830 ^@ http://purl.uniprot.org/uniprot/D2HMK5 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus speckle http://togogenome.org/gene/9646:CUL4B ^@ http://purl.uniprot.org/uniprot/G1L043 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9646:TAS2R1 ^@ http://purl.uniprot.org/uniprot/D2H9X0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9646:MRFAP1 ^@ http://purl.uniprot.org/uniprot/D2I7X6 ^@ Similarity ^@ Belongs to the MORF4 family-associated protein family. http://togogenome.org/gene/9646:RPL6 ^@ http://purl.uniprot.org/uniprot/D2HRU8|||http://purl.uniprot.org/uniprot/F2X236 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL6 family. http://togogenome.org/gene/9646:GLRA1 ^@ http://purl.uniprot.org/uniprot/G1LMJ3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane|||dendrite http://togogenome.org/gene/9646:PSME4 ^@ http://purl.uniprot.org/uniprot/D2GY87 ^@ Similarity ^@ Belongs to the BLM10 family. http://togogenome.org/gene/9646:AFM ^@ http://purl.uniprot.org/uniprot/G1LE42 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9646:KEG54_p07 ^@ http://purl.uniprot.org/uniprot/A5JFK2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9646:HSD17B10 ^@ http://purl.uniprot.org/uniprot/G1LEJ1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9646:ZC2HC1C ^@ http://purl.uniprot.org/uniprot/G1MJ32 ^@ Similarity ^@ Belongs to the ZC2HC1 family. http://togogenome.org/gene/9646:CCL19 ^@ http://purl.uniprot.org/uniprot/G1LK30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9646:UGDH ^@ http://purl.uniprot.org/uniprot/A0A7N5JAE2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.|||Homohexamer.|||Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. http://togogenome.org/gene/9646:AGPAT1 ^@ http://purl.uniprot.org/uniprot/G1L6S2 ^@ Domain|||Function|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/9646:CHEK1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KJU4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily. http://togogenome.org/gene/9646:TEF ^@ http://purl.uniprot.org/uniprot/A0A7N5JMJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/9646:ASZ1 ^@ http://purl.uniprot.org/uniprot/D2H6R1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.|||Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation. http://togogenome.org/gene/9646:POLR2E ^@ http://purl.uniprot.org/uniprot/G1L8X2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process.|||Nucleus http://togogenome.org/gene/9646:TMEM225B ^@ http://purl.uniprot.org/uniprot/G1LHY2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:FNIP1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JPJ5|||http://purl.uniprot.org/uniprot/G1MGW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNIP family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9646:NUPR1 ^@ http://purl.uniprot.org/uniprot/A0A7N5J9Q0 ^@ Similarity ^@ Belongs to the NUPR family. http://togogenome.org/gene/9646:PTGR1 ^@ http://purl.uniprot.org/uniprot/D2H4E4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADP-dependent oxidoreductase L4BD family.|||Cytoplasm|||Monomer or homodimer. http://togogenome.org/gene/9646:INTS12 ^@ http://purl.uniprot.org/uniprot/D2HPF2 ^@ Similarity|||Subunit ^@ Belongs to the Integrator subunit 12 family.|||Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12. http://togogenome.org/gene/9646:SPRTN ^@ http://purl.uniprot.org/uniprot/D2H5X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Spartan family.|||Chromosome|||Nucleus http://togogenome.org/gene/9646:DDX47 ^@ http://purl.uniprot.org/uniprot/G1LW60 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily. http://togogenome.org/gene/9646:PRC1 ^@ http://purl.uniprot.org/uniprot/A0A7N5P329|||http://purl.uniprot.org/uniprot/G1M4Z4 ^@ Similarity ^@ Belongs to the MAP65/ASE1 family. http://togogenome.org/gene/9646:SSTR5 ^@ http://purl.uniprot.org/uniprot/D2HDY0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:NAT10 ^@ http://purl.uniprot.org/uniprot/A0A7N5KGN4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.|||Interacts with THUMPD1.|||RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.|||nucleolus http://togogenome.org/gene/9646:THEMIS2 ^@ http://purl.uniprot.org/uniprot/G1LX98 ^@ Similarity ^@ Belongs to the themis family. http://togogenome.org/gene/9646:SLC39A1 ^@ http://purl.uniprot.org/uniprot/D2HJQ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:ROMO1 ^@ http://purl.uniprot.org/uniprot/D2H457 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGR2 family.|||Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.|||Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:AK1 ^@ http://purl.uniprot.org/uniprot/G1M9F0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK1 subfamily.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9646:TRAPPC6B ^@ http://purl.uniprot.org/uniprot/G1LB30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||cis-Golgi network http://togogenome.org/gene/9646:INHBC ^@ http://purl.uniprot.org/uniprot/D2H381 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/9646:TMEM106C ^@ http://purl.uniprot.org/uniprot/D2HE74 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/9646:RAB33B ^@ http://purl.uniprot.org/uniprot/D2H3G3 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Rab family. http://togogenome.org/gene/9646:SST ^@ http://purl.uniprot.org/uniprot/D2H067 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatostatin family.|||Secreted http://togogenome.org/gene/9646:RDH10 ^@ http://purl.uniprot.org/uniprot/D2HVD9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9646:DNAJB12 ^@ http://purl.uniprot.org/uniprot/D2HZB1 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:SCAMP3 ^@ http://purl.uniprot.org/uniprot/D2HZL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/9646:NID1 ^@ http://purl.uniprot.org/uniprot/D2HZI0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/9646:CACNG7 ^@ http://purl.uniprot.org/uniprot/D2HYP9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. http://togogenome.org/gene/9646:BMP2 ^@ http://purl.uniprot.org/uniprot/D2HR91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/9646:CTSS ^@ http://purl.uniprot.org/uniprot/G1L3B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9646:NOB1 ^@ http://purl.uniprot.org/uniprot/D2HMP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOB1 family.|||Nucleus http://togogenome.org/gene/9646:TK2 ^@ http://purl.uniprot.org/uniprot/A0A7N5P5F6 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/9646:LOC100467660 ^@ http://purl.uniprot.org/uniprot/A0A7N5JQN9|||http://purl.uniprot.org/uniprot/G1LUN9 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit.|||Glycosylated. http://togogenome.org/gene/9646:CALHM5 ^@ http://purl.uniprot.org/uniprot/G1LGF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9646:TLR8 ^@ http://purl.uniprot.org/uniprot/G1MN77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9646:GJB5 ^@ http://purl.uniprot.org/uniprot/D2H621 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9646:CRP ^@ http://purl.uniprot.org/uniprot/A0A7N5JME2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pentraxin family.|||Binds 2 calcium ions per subunit.|||Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.|||Secreted http://togogenome.org/gene/9646:IDE ^@ http://purl.uniprot.org/uniprot/A0A7N5P7E7|||http://purl.uniprot.org/uniprot/D2H3D7 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/9646:RASGRP2 ^@ http://purl.uniprot.org/uniprot/A0A7N5KR88 ^@ Similarity ^@ Belongs to the RASGRP family. http://togogenome.org/gene/9646:ORC1 ^@ http://purl.uniprot.org/uniprot/D2H2D8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC1 family.|||Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with CDC6 and KAT7/HBO1. Interacts with LRWD1 predominantly during the G1 phase and with less affinity during mitosis, when phosphorylated.|||Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.|||Nucleus http://togogenome.org/gene/9646:MBTPS1 ^@ http://purl.uniprot.org/uniprot/D2HRI4 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9646:BBS7 ^@ http://purl.uniprot.org/uniprot/G1LHM7 ^@ Function|||Subunit ^@ Part of BBSome complex.|||The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. http://togogenome.org/gene/9646:TXK ^@ http://purl.uniprot.org/uniprot/G1L8Z6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane http://togogenome.org/gene/9646:NUDT2 ^@ http://purl.uniprot.org/uniprot/A0A7N5J8G1 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/9646:TMTC3 ^@ http://purl.uniprot.org/uniprot/D2HHQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/9646:GIMD1 ^@ http://purl.uniprot.org/uniprot/G1MGK4 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9646:ODF1 ^@ http://purl.uniprot.org/uniprot/D2HJX0 ^@ Function ^@ Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. http://togogenome.org/gene/9646:MRPS33 ^@ http://purl.uniprot.org/uniprot/G1M9Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS33 family.|||Mitochondrion http://togogenome.org/gene/9646:PPIL4 ^@ http://purl.uniprot.org/uniprot/G1MIY4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.|||Nucleus|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9646:LOC100475112 ^@ http://purl.uniprot.org/uniprot/A0A7N5K1W6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9646:NDUFV2 ^@ http://purl.uniprot.org/uniprot/G1LLJ5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. http://togogenome.org/gene/9646:C1GALT1 ^@ http://purl.uniprot.org/uniprot/D2HD12 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:RPS9 ^@ http://purl.uniprot.org/uniprot/D2HYR2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/9646:ACP7 ^@ http://purl.uniprot.org/uniprot/G1LQ26 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family. http://togogenome.org/gene/9646:PRRX1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KP20|||http://purl.uniprot.org/uniprot/D2H9S2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/9646:C12H12orf43 ^@ http://purl.uniprot.org/uniprot/G1LP35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUSTOS family.|||Nucleus envelope http://togogenome.org/gene/9646:RPL15 ^@ http://purl.uniprot.org/uniprot/D2HKU3|||http://purl.uniprot.org/uniprot/D7RAF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL15 family.|||Cytoplasm http://togogenome.org/gene/9646:CLCN5 ^@ http://purl.uniprot.org/uniprot/G1M083 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.|||Cell membrane|||Endosome membrane|||Golgi apparatus membrane|||Interacts with NEDD4 and NEDD4L.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:ARHGEF3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JI25|||http://purl.uniprot.org/uniprot/A0A7N5KAE6|||http://purl.uniprot.org/uniprot/G1LYX5 ^@ Function|||Subcellular Location Annotation ^@ Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.|||Cytoplasm http://togogenome.org/gene/9646:GTF2E1 ^@ http://purl.uniprot.org/uniprot/D2HTQ9 ^@ Function|||Similarity ^@ Belongs to the TFIIE alpha subunit family.|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. http://togogenome.org/gene/9646:AGO1 ^@ http://purl.uniprot.org/uniprot/G1L139 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the argonaute family.|||P-body http://togogenome.org/gene/9646:NDUFA1 ^@ http://purl.uniprot.org/uniprot/G1KZY3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA1 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:CD38 ^@ http://purl.uniprot.org/uniprot/G1L452 ^@ Similarity ^@ Belongs to the ADP-ribosyl cyclase family. http://togogenome.org/gene/9646:STEAP1 ^@ http://purl.uniprot.org/uniprot/D2HE07 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:ATF7IP ^@ http://purl.uniprot.org/uniprot/D2H859 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCAF family.|||Nucleus http://togogenome.org/gene/9646:LOC100468944 ^@ http://purl.uniprot.org/uniprot/D2HZU2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9646:CPLX3 ^@ http://purl.uniprot.org/uniprot/D2HKY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9646:MFSD8 ^@ http://purl.uniprot.org/uniprot/G1L7J8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:SPTSSB ^@ http://purl.uniprot.org/uniprot/D2I3N4 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:EFNB1 ^@ http://purl.uniprot.org/uniprot/D2H889 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:ACTR2 ^@ http://purl.uniprot.org/uniprot/G1MB95 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9646:GGCX ^@ http://purl.uniprot.org/uniprot/G1L651 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:CNRIP1 ^@ http://purl.uniprot.org/uniprot/D2HS15|||http://purl.uniprot.org/uniprot/G1LE54 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CNRIP family.|||Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.|||Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. http://togogenome.org/gene/9646:KCNF1 ^@ http://purl.uniprot.org/uniprot/D2HH95 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:CCNG1 ^@ http://purl.uniprot.org/uniprot/D2HVU6 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9646:CD79B ^@ http://purl.uniprot.org/uniprot/G1L8H1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9646:TRAPPC4 ^@ http://purl.uniprot.org/uniprot/D2I333 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/9646:SDHA ^@ http://purl.uniprot.org/uniprot/G1LPI9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.|||Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/9646:MAST4 ^@ http://purl.uniprot.org/uniprot/A0A7N5JW90 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/9646:VPS52 ^@ http://purl.uniprot.org/uniprot/G1L4D9 ^@ Similarity ^@ Belongs to the VPS52 family. http://togogenome.org/gene/9646:RAD1 ^@ http://purl.uniprot.org/uniprot/D2HC19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad1 family.|||Nucleus http://togogenome.org/gene/9646:VDR ^@ http://purl.uniprot.org/uniprot/D2HE73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:PARP14 ^@ http://purl.uniprot.org/uniprot/G1LE13 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9646:UTP11 ^@ http://purl.uniprot.org/uniprot/G1L3B8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UTP11 family.|||Component of the ribosomal small subunit (SSU) processome.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/9646:NIPSNAP1 ^@ http://purl.uniprot.org/uniprot/G1LNG5 ^@ Similarity ^@ Belongs to the NipSnap family. http://togogenome.org/gene/9646:REEP4 ^@ http://purl.uniprot.org/uniprot/G1L9I1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:AURKAIP1 ^@ http://purl.uniprot.org/uniprot/D2I3Q9 ^@ Similarity ^@ Belongs to the mitochondrion-specific ribosomal protein mS38 family. http://togogenome.org/gene/9646:SMIM5 ^@ http://purl.uniprot.org/uniprot/G1LSQ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:WEE2 ^@ http://purl.uniprot.org/uniprot/D2HHP1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.|||Nucleus|||Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity).|||Phosphorylation leads to increase its activity. http://togogenome.org/gene/9646:CHPF ^@ http://purl.uniprot.org/uniprot/D2HQR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9646:TMSB4X ^@ http://purl.uniprot.org/uniprot/D2H0S9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||cytoskeleton http://togogenome.org/gene/9646:KCNJ15 ^@ http://purl.uniprot.org/uniprot/D2I6U1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9646:RPL14 ^@ http://purl.uniprot.org/uniprot/F2X251 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL14 family. http://togogenome.org/gene/9646:PPAT ^@ http://purl.uniprot.org/uniprot/D2H8I4 ^@ Cofactor|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/9646:CD3D ^@ http://purl.uniprot.org/uniprot/A0A7N5KGS1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9646:LOC100479867 ^@ http://purl.uniprot.org/uniprot/D2HX52 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9646:EIF4E2 ^@ http://purl.uniprot.org/uniprot/A0A7N5K1J9|||http://purl.uniprot.org/uniprot/G1MDG2|||http://purl.uniprot.org/uniprot/G1MDG4 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/9646:LIN52 ^@ http://purl.uniprot.org/uniprot/A0A7N5JQB2 ^@ Similarity ^@ Belongs to the lin-52 family. http://togogenome.org/gene/9646:HOXB6 ^@ http://purl.uniprot.org/uniprot/D2H568 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9646:GPR65 ^@ http://purl.uniprot.org/uniprot/D2HW49 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:EMC6 ^@ http://purl.uniprot.org/uniprot/D2HZP2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC6 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:CCDC103 ^@ http://purl.uniprot.org/uniprot/D2HCW7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CCDC103/PR46b family.|||Cytoplasm|||Dynein-attachment factor required for cilia motility.|||Homodimer.|||flagellum http://togogenome.org/gene/9646:GRB10 ^@ http://purl.uniprot.org/uniprot/G1LMY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRB7/10/14 family.|||Cytoplasm http://togogenome.org/gene/9646:SOHLH2 ^@ http://purl.uniprot.org/uniprot/G1LD90 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:LOC100474600 ^@ http://purl.uniprot.org/uniprot/A0A7N5JJT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9646:LOC100472050 ^@ http://purl.uniprot.org/uniprot/A0A7N5K2K6|||http://purl.uniprot.org/uniprot/G1LFN5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. http://togogenome.org/gene/9646:EPYC ^@ http://purl.uniprot.org/uniprot/D2HXD5 ^@ Similarity ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. http://togogenome.org/gene/9646:PRKAB2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JAG0|||http://purl.uniprot.org/uniprot/D2I2Z7 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/9646:LOC100477356 ^@ http://purl.uniprot.org/uniprot/D2I0C6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:NCAPD3 ^@ http://purl.uniprot.org/uniprot/G1LL24 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the condensin-2 complex.|||Nucleus|||Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. http://togogenome.org/gene/9646:LTV1 ^@ http://purl.uniprot.org/uniprot/G1LYF8 ^@ Similarity ^@ Belongs to the LTV1 family. http://togogenome.org/gene/9646:LOC100465533 ^@ http://purl.uniprot.org/uniprot/G1MNU0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:PMS1 ^@ http://purl.uniprot.org/uniprot/D2HA18 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/9646:NDUFAF7 ^@ http://purl.uniprot.org/uniprot/D2H088 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).|||Belongs to the NDUFAF7 family.|||Mitochondrion http://togogenome.org/gene/9646:PITPNM1 ^@ http://purl.uniprot.org/uniprot/G1L2C7 ^@ Similarity ^@ Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily. http://togogenome.org/gene/9646:LOC100464523 ^@ http://purl.uniprot.org/uniprot/G1MNT5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:TMBIM6 ^@ http://purl.uniprot.org/uniprot/G1L2E8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9646:PRKCE ^@ http://purl.uniprot.org/uniprot/A0A7N5KCC1 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration.|||Cell membrane|||Cytoplasm|||Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.|||Nucleus|||cytoskeleton|||perinuclear region http://togogenome.org/gene/9646:ATP8A1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KM09|||http://purl.uniprot.org/uniprot/G1M2X4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9646:MASP1 ^@ http://purl.uniprot.org/uniprot/A0A7N5P438 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:WNT3 ^@ http://purl.uniprot.org/uniprot/G1MCZ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9646:TRAPPC13 ^@ http://purl.uniprot.org/uniprot/A0A7N5JKD6|||http://purl.uniprot.org/uniprot/G1LXH6 ^@ Similarity|||Subunit ^@ Belongs to the TRAPPC13 family.|||Part of the multisubunit TRAPP (transport protein particle) complex. http://togogenome.org/gene/9646:BROX ^@ http://purl.uniprot.org/uniprot/G1LJV1 ^@ Similarity ^@ Belongs to the BROX family. http://togogenome.org/gene/9646:CMTM6 ^@ http://purl.uniprot.org/uniprot/D2HSU2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:CXCL11 ^@ http://purl.uniprot.org/uniprot/A0A7N5KP95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9646:MTMR9 ^@ http://purl.uniprot.org/uniprot/D2I0R1 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9646:SLC39A9 ^@ http://purl.uniprot.org/uniprot/D2H5Q7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Cell membrane|||Membrane|||Mitochondrion|||Nucleus|||Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process.|||perinuclear region|||trans-Golgi network membrane http://togogenome.org/gene/9646:SLC25A36 ^@ http://purl.uniprot.org/uniprot/G1MDJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9646:SENP8 ^@ http://purl.uniprot.org/uniprot/G1MP05 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/9646:ZNF263 ^@ http://purl.uniprot.org/uniprot/A0A7N5JF71|||http://purl.uniprot.org/uniprot/D2HQZ6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:CDK5 ^@ http://purl.uniprot.org/uniprot/G1M5B9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9646:RGN ^@ http://purl.uniprot.org/uniprot/G1M307 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMP-30/CGR1 family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9646:SDC2 ^@ http://purl.uniprot.org/uniprot/G1LLB4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane http://togogenome.org/gene/9646:TMEM167B ^@ http://purl.uniprot.org/uniprot/G1LD07 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KISH family.|||Golgi apparatus membrane|||Involved in the early part of the secretory pathway.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:CCDC124 ^@ http://purl.uniprot.org/uniprot/D2GV19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC124 family.|||Midbody http://togogenome.org/gene/9646:DNASE1L3 ^@ http://purl.uniprot.org/uniprot/G1LZS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNase I family.|||Nucleus envelope|||Zymogen granule http://togogenome.org/gene/9646:VAMP4 ^@ http://purl.uniprot.org/uniprot/G1MEX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9646:SHMT1 ^@ http://purl.uniprot.org/uniprot/G1LDK7 ^@ Function|||Similarity ^@ Belongs to the SHMT family.|||Interconversion of serine and glycine. http://togogenome.org/gene/9646:DCAF1 ^@ http://purl.uniprot.org/uniprot/G1LRY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPRBP/DCAF1 family.|||Nucleus http://togogenome.org/gene/9646:BMP15 ^@ http://purl.uniprot.org/uniprot/D2I5P3 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9646:MALL ^@ http://purl.uniprot.org/uniprot/G1LT13 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:PRKCG ^@ http://purl.uniprot.org/uniprot/D2HYP8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.|||Cytoplasm|||Membrane http://togogenome.org/gene/9646:HOXB9 ^@ http://purl.uniprot.org/uniprot/D2H571 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9646:ATP6V0B ^@ http://purl.uniprot.org/uniprot/G1L2P8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9646:NGRN ^@ http://purl.uniprot.org/uniprot/D2HCY6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the neugrin family.|||Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct.|||Mitochondrion membrane|||Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system. http://togogenome.org/gene/9646:SCN1B ^@ http://purl.uniprot.org/uniprot/G1L002 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:CCNA2 ^@ http://purl.uniprot.org/uniprot/D2HN58 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin AB subfamily. http://togogenome.org/gene/9646:CREB1 ^@ http://purl.uniprot.org/uniprot/D2H8G8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:ADTRP ^@ http://purl.uniprot.org/uniprot/G1L7H7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIG1 family.|||Membrane http://togogenome.org/gene/9646:GNL2 ^@ http://purl.uniprot.org/uniprot/G1L2J7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.|||GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.|||nucleolus http://togogenome.org/gene/9646:ZSCAN26 ^@ http://purl.uniprot.org/uniprot/A0A7N5P589 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:DMAP1 ^@ http://purl.uniprot.org/uniprot/G1M614 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:RPL36 ^@ http://purl.uniprot.org/uniprot/F2X284 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL36 family. http://togogenome.org/gene/9646:TPPP3 ^@ http://purl.uniprot.org/uniprot/D2H9E4 ^@ Similarity ^@ Belongs to the TPPP family. http://togogenome.org/gene/9646:HSPB1 ^@ http://purl.uniprot.org/uniprot/G8A3I2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Nucleus|||spindle http://togogenome.org/gene/9646:FBP2 ^@ http://purl.uniprot.org/uniprot/G1LYB9 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/9646:WIF1 ^@ http://purl.uniprot.org/uniprot/D2HDL2 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9646:KRI1 ^@ http://purl.uniprot.org/uniprot/G1LY39 ^@ Similarity ^@ Belongs to the KRI1 family. http://togogenome.org/gene/9646:DOLK ^@ http://purl.uniprot.org/uniprot/D2H154 ^@ Similarity ^@ Belongs to the polyprenol kinase family. http://togogenome.org/gene/9646:NDUFB8 ^@ http://purl.uniprot.org/uniprot/G1LJA4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB8 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:DHFR ^@ http://purl.uniprot.org/uniprot/G1MB80 ^@ Similarity ^@ Belongs to the dihydrofolate reductase family. http://togogenome.org/gene/9646:SYT17 ^@ http://purl.uniprot.org/uniprot/A0A7N5P8E7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Membrane http://togogenome.org/gene/9646:C8A ^@ http://purl.uniprot.org/uniprot/G1LBN3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9646:XKRX ^@ http://purl.uniprot.org/uniprot/G1LRB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9646:GCK ^@ http://purl.uniprot.org/uniprot/A0A7N5JAA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hexokinase family.|||Membrane|||Mitochondrion outer membrane|||cytosol http://togogenome.org/gene/9646:LOC100468655 ^@ http://purl.uniprot.org/uniprot/A0A7N5KE34|||http://purl.uniprot.org/uniprot/A0A7N5KRG0 ^@ Function|||Similarity ^@ Belongs to the CMP-Neu5Ac hydroxylase family.|||Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells. http://togogenome.org/gene/9646:DCP2 ^@ http://purl.uniprot.org/uniprot/G1M1Q3 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DCP2 subfamily. http://togogenome.org/gene/9646:GJB1 ^@ http://purl.uniprot.org/uniprot/D2I1L5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins. Interacts with CNST.|||Belongs to the connexin family. Beta-type (group I) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9646:RRAGB ^@ http://purl.uniprot.org/uniprot/D2I2Z2|||http://purl.uniprot.org/uniprot/G1M2R6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/9646:TMEM199 ^@ http://purl.uniprot.org/uniprot/D2GU40 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:UBE2B ^@ http://purl.uniprot.org/uniprot/G1MHK7 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9646:GSX1 ^@ http://purl.uniprot.org/uniprot/D2HWR5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:ZSCAN20 ^@ http://purl.uniprot.org/uniprot/D2HI41 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9646:DGUOK ^@ http://purl.uniprot.org/uniprot/G1MG75 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/9646:CKAP2L ^@ http://purl.uniprot.org/uniprot/G1LW65 ^@ Similarity ^@ Belongs to the CKAP2 family. http://togogenome.org/gene/9646:DCTN2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JKN4|||http://purl.uniprot.org/uniprot/G1LEL0 ^@ Similarity ^@ Belongs to the dynactin subunit 2 family. http://togogenome.org/gene/9646:HAO2 ^@ http://purl.uniprot.org/uniprot/G1MH58 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/9646:TMCO5A ^@ http://purl.uniprot.org/uniprot/G1LP10 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:LOC100468099 ^@ http://purl.uniprot.org/uniprot/G1MJN4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:HOXC5 ^@ http://purl.uniprot.org/uniprot/D2HM47|||http://purl.uniprot.org/uniprot/G1L1G9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9646:FBLN5 ^@ http://purl.uniprot.org/uniprot/A0A7N5KNP1|||http://purl.uniprot.org/uniprot/G1M8Q7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:SLC8A3 ^@ http://purl.uniprot.org/uniprot/A0A7N5KAA0|||http://purl.uniprot.org/uniprot/G1M7U9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:ART5 ^@ http://purl.uniprot.org/uniprot/G1LWS0 ^@ Similarity ^@ Belongs to the Arg-specific ADP-ribosyltransferase family. http://togogenome.org/gene/9646:POLL ^@ http://purl.uniprot.org/uniprot/A0A7N5JP00|||http://purl.uniprot.org/uniprot/G1MGY1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.|||Nucleus http://togogenome.org/gene/9646:HOOK2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JH74|||http://purl.uniprot.org/uniprot/G1M0S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hook family.|||cytoskeleton http://togogenome.org/gene/9646:NIPBL ^@ http://purl.uniprot.org/uniprot/A0A7N5K622 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCC2/Nipped-B family.|||Nucleus http://togogenome.org/gene/9646:IL26 ^@ http://purl.uniprot.org/uniprot/D2H945 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/9646:LOC100469796 ^@ http://purl.uniprot.org/uniprot/A0A7N5K081|||http://purl.uniprot.org/uniprot/G1LAK9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FXYD family.|||May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.|||Membrane|||Regulatory subunit of the sodium/potassium-transporting ATPase which is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. http://togogenome.org/gene/9646:NHEJ1 ^@ http://purl.uniprot.org/uniprot/G1L712 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XRCC4-XLF family. XLF subfamily.|||Nucleus http://togogenome.org/gene/9646:EBF2 ^@ http://purl.uniprot.org/uniprot/G1L0F2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COE family.|||Nucleus http://togogenome.org/gene/9646:LOC100480936 ^@ http://purl.uniprot.org/uniprot/G1M8F4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP23 family.|||Membrane http://togogenome.org/gene/9646:RAD18 ^@ http://purl.uniprot.org/uniprot/G1M127 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAD18 family.|||Nucleus http://togogenome.org/gene/9646:SLC66A3 ^@ http://purl.uniprot.org/uniprot/D2HH97 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:VPS35 ^@ http://purl.uniprot.org/uniprot/G1MJ51 ^@ Function|||Similarity ^@ Belongs to the VPS35 family.|||Plays a role in vesicular protein sorting. http://togogenome.org/gene/9646:SLC2A3 ^@ http://purl.uniprot.org/uniprot/G1MF91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane http://togogenome.org/gene/9646:ARHGAP26 ^@ http://purl.uniprot.org/uniprot/A0A7N5JKZ3 ^@ Subcellular Location Annotation ^@ cytoskeleton|||focal adhesion http://togogenome.org/gene/9646:E2F8 ^@ http://purl.uniprot.org/uniprot/G1MHY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9646:TIMM9 ^@ http://purl.uniprot.org/uniprot/D2GVR2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9646:DDAH2 ^@ http://purl.uniprot.org/uniprot/D2I498 ^@ Function|||Similarity ^@ Belongs to the DDAH family.|||Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. http://togogenome.org/gene/9646:NR1D1 ^@ http://purl.uniprot.org/uniprot/G1LME6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9646:FABP1 ^@ http://purl.uniprot.org/uniprot/G1LU22 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.|||Cytoplasm|||Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. http://togogenome.org/gene/9646:LOC100474142 ^@ http://purl.uniprot.org/uniprot/D2HJC9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:SUPT4H1 ^@ http://purl.uniprot.org/uniprot/G1LYX7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT4 family.|||Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.|||Nucleus http://togogenome.org/gene/9646:PNPO ^@ http://purl.uniprot.org/uniprot/D2H555|||http://purl.uniprot.org/uniprot/G1LDU2 ^@ Function|||Similarity ^@ Belongs to the pyridoxamine 5'-phosphate oxidase family.|||Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). http://togogenome.org/gene/9646:CDK20 ^@ http://purl.uniprot.org/uniprot/G1L994 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.|||cilium http://togogenome.org/gene/9646:NSUN7 ^@ http://purl.uniprot.org/uniprot/D2HV52 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:CCDC65 ^@ http://purl.uniprot.org/uniprot/G1LKJ8 ^@ Subcellular Location Annotation ^@ flagellum axoneme http://togogenome.org/gene/9646:FAM135A ^@ http://purl.uniprot.org/uniprot/A0A7N5K457 ^@ Similarity ^@ Belongs to the FAM135 family. http://togogenome.org/gene/9646:LOC100481237 ^@ http://purl.uniprot.org/uniprot/D2H3D3 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9646:EXTL3 ^@ http://purl.uniprot.org/uniprot/D2HAJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:NUP107 ^@ http://purl.uniprot.org/uniprot/G1LPV3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nucleoporin Nup84/Nup107 family.|||Functions as a component of the nuclear pore complex (NPC).|||Nucleus membrane|||Part of the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/9646:EIF3I ^@ http://purl.uniprot.org/uniprot/G1LMI2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit I family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm|||Phosphorylated by TGF-beta type II receptor. http://togogenome.org/gene/9646:PLPP5 ^@ http://purl.uniprot.org/uniprot/G1LXN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9646:NSRP1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KN26 ^@ Similarity ^@ Belongs to the NSRP1 family. http://togogenome.org/gene/9646:ATP6V1B1 ^@ http://purl.uniprot.org/uniprot/D2H0D7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the ATPase alpha/beta chains family.|||Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits. http://togogenome.org/gene/9646:SGSH ^@ http://purl.uniprot.org/uniprot/G1M9N9 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9646:FTMT ^@ http://purl.uniprot.org/uniprot/D2HAR2 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/9646:POLR2F ^@ http://purl.uniprot.org/uniprot/G1LUW9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.|||Nucleus http://togogenome.org/gene/9646:CLCN1 ^@ http://purl.uniprot.org/uniprot/G1LJD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Membrane http://togogenome.org/gene/9646:GAD1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JG49 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9646:LOC100470383 ^@ http://purl.uniprot.org/uniprot/D2HTW4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:WDR55 ^@ http://purl.uniprot.org/uniprot/D2GUN6 ^@ Function|||Similarity ^@ Belongs to the WD repeat WDR55 family.|||Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis. http://togogenome.org/gene/9646:FOXF1 ^@ http://purl.uniprot.org/uniprot/G1MIW9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:GPBP1 ^@ http://purl.uniprot.org/uniprot/G1LAJ8|||http://purl.uniprot.org/uniprot/G1LAK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vasculin family.|||Nucleus http://togogenome.org/gene/9646:AQP1 ^@ http://purl.uniprot.org/uniprot/D2HBL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:STX7 ^@ http://purl.uniprot.org/uniprot/G1LVM7 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9646:SNX11 ^@ http://purl.uniprot.org/uniprot/A0A7N5P944|||http://purl.uniprot.org/uniprot/D2H561|||http://purl.uniprot.org/uniprot/G1LE53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane http://togogenome.org/gene/9646:ACOT8 ^@ http://purl.uniprot.org/uniprot/G1M1P2 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/9646:PTS ^@ http://purl.uniprot.org/uniprot/G1LBC1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the PTPS family.|||Binds 1 zinc ion per subunit.|||Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. http://togogenome.org/gene/9646:SLC25A16 ^@ http://purl.uniprot.org/uniprot/G1MI54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9646:SOX14 ^@ http://purl.uniprot.org/uniprot/D2HLV9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:HEXD ^@ http://purl.uniprot.org/uniprot/G1L2Z5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 20 family. http://togogenome.org/gene/9646:SPRING1 ^@ http://purl.uniprot.org/uniprot/D2HFB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPRING family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:ILK ^@ http://purl.uniprot.org/uniprot/D2HR59 ^@ Subcellular Location Annotation ^@ focal adhesion|||lamellipodium|||sarcomere http://togogenome.org/gene/9646:MDK ^@ http://purl.uniprot.org/uniprot/G1LJK9 ^@ Similarity ^@ Belongs to the pleiotrophin family. http://togogenome.org/gene/9646:ETFDH ^@ http://purl.uniprot.org/uniprot/A0A7N5P9U8|||http://purl.uniprot.org/uniprot/G1L6D0 ^@ Cofactor|||Function ^@ Accepts electrons from ETF and reduces ubiquinone.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/9646:ZNF706 ^@ http://purl.uniprot.org/uniprot/D2GY29 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9646:TMEM251 ^@ http://purl.uniprot.org/uniprot/G1M4T9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LYSET family.|||Membrane http://togogenome.org/gene/9646:HEXIM1 ^@ http://purl.uniprot.org/uniprot/D2HCX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HEXIM family.|||Nucleus http://togogenome.org/gene/9646:LYRM1 ^@ http://purl.uniprot.org/uniprot/D2HXQ6 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9646:LOC100477929 ^@ http://purl.uniprot.org/uniprot/D2HVS9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9646:MKS1 ^@ http://purl.uniprot.org/uniprot/D2I2K1 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/9646:AWAT2 ^@ http://purl.uniprot.org/uniprot/G1LR39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9646:CPLX1 ^@ http://purl.uniprot.org/uniprot/G1MEB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9646:FAM53A ^@ http://purl.uniprot.org/uniprot/A0A7N5KEI6 ^@ Similarity ^@ Belongs to the FAM53 family. http://togogenome.org/gene/9646:CA11 ^@ http://purl.uniprot.org/uniprot/G1M8F5 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Does not have a catalytic activity. http://togogenome.org/gene/9646:RFWD3 ^@ http://purl.uniprot.org/uniprot/D2HWM5 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage. Plays a key role in RPA-mediated DNA damage signaling and repair. Acts by mediating ubiquitination of the RPA complex (RPA1, RPA2 and RPA3 subunits) and RAD51 at stalled replication forks, leading to remove them from DNA damage sites and promote homologous recombination. Also mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53.|||Interacts with MDM2 and p53/TP53. Binds to the RPA complex via direct interaction with RPA2. Interacts with RAD51.|||Nucleus|||PML body|||Phosphorylated at Ser-46 and Ser-63 upon DNA damage by ATM or ATR. ATM phosphorylation occurs at early times upon DNA damage, while ATR is the major kinase at later times. Phosphorylation by ATM and ATR is required to stabilize p53/TP53. Part of the phosphorylation depends upon RPA2 presence.|||The coiled coil domain may be involved in RPA2-binding. http://togogenome.org/gene/9646:TMEM41B ^@ http://purl.uniprot.org/uniprot/D2H3H9|||http://purl.uniprot.org/uniprot/G1LBD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM41 family.|||Membrane http://togogenome.org/gene/9646:LOC100483970 ^@ http://purl.uniprot.org/uniprot/A0A7N5K740 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:ATP6V1D ^@ http://purl.uniprot.org/uniprot/G1LNQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase D subunit family.|||cilium|||clathrin-coated vesicle membrane http://togogenome.org/gene/9646:SEC61A1 ^@ http://purl.uniprot.org/uniprot/A0A7N5K9L4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:POLR2K ^@ http://purl.uniprot.org/uniprot/A0A7N5JDZ3 ^@ Similarity ^@ Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family. http://togogenome.org/gene/9646:MPEG1 ^@ http://purl.uniprot.org/uniprot/D2HZE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MPEG1 family.|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/9646:PTH ^@ http://purl.uniprot.org/uniprot/D2HU58 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the parathyroid hormone family.|||Interacts with PTH1R (via N-terminal extracellular domain).|||PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.|||Secreted http://togogenome.org/gene/9646:BRS3 ^@ http://purl.uniprot.org/uniprot/G1L874 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with C6orf89.|||Membrane http://togogenome.org/gene/9646:LIX1 ^@ http://purl.uniprot.org/uniprot/D2HCJ9 ^@ Similarity ^@ Belongs to the LIX1 family. http://togogenome.org/gene/9646:LOC100470307 ^@ http://purl.uniprot.org/uniprot/D2I2B7 ^@ Function|||Subunit ^@ In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9646:SLC1A7 ^@ http://purl.uniprot.org/uniprot/D2H2E9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9646:KRT8 ^@ http://purl.uniprot.org/uniprot/D2HLN8 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9646:LAMA3 ^@ http://purl.uniprot.org/uniprot/A0A7N5KCN7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/9646:MRTO4 ^@ http://purl.uniprot.org/uniprot/G1L8I2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the pre-60S ribosomal particle.|||Belongs to the universal ribosomal protein uL10 family.|||Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.|||Cytoplasm|||nucleolus http://togogenome.org/gene/9646:TBC1D24 ^@ http://purl.uniprot.org/uniprot/D2HV77|||http://purl.uniprot.org/uniprot/G1MI01 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasmic vesicle membrane|||Interacts with ARF6.|||Membrane|||Presynapse http://togogenome.org/gene/9646:IL3RA ^@ http://purl.uniprot.org/uniprot/G1LG96 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:NUDT21 ^@ http://purl.uniprot.org/uniprot/G1MDZ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family. CPSF5 subfamily.|||Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.|||Cytoplasm|||Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.|||Nucleus http://togogenome.org/gene/9646:DDX27 ^@ http://purl.uniprot.org/uniprot/G1M4Y6 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9646:BMS1 ^@ http://purl.uniprot.org/uniprot/G1MEP1 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9646:ZER1 ^@ http://purl.uniprot.org/uniprot/G1MBB1 ^@ Similarity ^@ Belongs to the zyg-11 family. http://togogenome.org/gene/9646:RPS3A ^@ http://purl.uniprot.org/uniprot/F2X201 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS1 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.|||Cytoplasm|||May play a role during erythropoiesis through regulation of transcription factor DDIT3.|||Nucleus|||nucleolus http://togogenome.org/gene/9646:TMEM87A ^@ http://purl.uniprot.org/uniprot/G1MCF8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:KEG54_p02 ^@ http://purl.uniprot.org/uniprot/A5JFK7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 6 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion inner membrane|||Mitochondrion membrane http://togogenome.org/gene/9646:MRPL37 ^@ http://purl.uniprot.org/uniprot/G1LT82 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9646:YWHAG ^@ http://purl.uniprot.org/uniprot/D2HM80 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9646:FAM163A ^@ http://purl.uniprot.org/uniprot/D2H3M1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM163 family.|||Membrane http://togogenome.org/gene/9646:SLC7A8 ^@ http://purl.uniprot.org/uniprot/A0A7N5JCZ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:CTH ^@ http://purl.uniprot.org/uniprot/G1KZI0 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/9646:TAP2 ^@ http://purl.uniprot.org/uniprot/A0A7N5KIX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.|||Membrane http://togogenome.org/gene/9646:TUBD1 ^@ http://purl.uniprot.org/uniprot/D2HLU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin family.|||Nucleus|||centriole|||cilium http://togogenome.org/gene/9646:TEK ^@ http://purl.uniprot.org/uniprot/G1L4T4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:TRMO ^@ http://purl.uniprot.org/uniprot/G1LDL3 ^@ Similarity ^@ Belongs to the tRNA methyltransferase O family. http://togogenome.org/gene/9646:LYPLAL1 ^@ http://purl.uniprot.org/uniprot/G1LWH5 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/9646:EXOG ^@ http://purl.uniprot.org/uniprot/A0A7N5KC43|||http://purl.uniprot.org/uniprot/G1MH57 ^@ Similarity ^@ Belongs to the DNA/RNA non-specific endonuclease family. http://togogenome.org/gene/9646:NSUN4 ^@ http://purl.uniprot.org/uniprot/G1M5U1 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/9646:PSMB7 ^@ http://purl.uniprot.org/uniprot/D2HDG5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:HACD3 ^@ http://purl.uniprot.org/uniprot/D2GYT1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:POLR1B ^@ http://purl.uniprot.org/uniprot/D2HUR1 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft. http://togogenome.org/gene/9646:EXOC3L1 ^@ http://purl.uniprot.org/uniprot/G1MFW1 ^@ Similarity ^@ Belongs to the SEC6 family. http://togogenome.org/gene/9646:TAF5 ^@ http://purl.uniprot.org/uniprot/D2GXX8 ^@ Similarity ^@ Belongs to the WD repeat TAF5 family. http://togogenome.org/gene/9646:MARK2 ^@ http://purl.uniprot.org/uniprot/A0A7N5KA23|||http://purl.uniprot.org/uniprot/G1MIH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||dendrite http://togogenome.org/gene/9646:BICD1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JVD2|||http://purl.uniprot.org/uniprot/A0A7N5P747|||http://purl.uniprot.org/uniprot/G1LQZ6 ^@ Similarity ^@ Belongs to the BicD family. http://togogenome.org/gene/9646:LPCAT3 ^@ http://purl.uniprot.org/uniprot/G1M560 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:SLC35A1 ^@ http://purl.uniprot.org/uniprot/G1LCQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:RPA4 ^@ http://purl.uniprot.org/uniprot/D2HT85 ^@ Similarity ^@ Belongs to the replication factor A protein 2 family. http://togogenome.org/gene/9646:SLC34A2 ^@ http://purl.uniprot.org/uniprot/D2HQ32 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the SLC34A transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:ADAM20 ^@ http://purl.uniprot.org/uniprot/G1MND1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:LOC100472112 ^@ http://purl.uniprot.org/uniprot/D2HGK1 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/9646:TPM3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JMT9|||http://purl.uniprot.org/uniprot/A0A7N5K2R8|||http://purl.uniprot.org/uniprot/D2HJP4|||http://purl.uniprot.org/uniprot/G1LZH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9646:CCN1 ^@ http://purl.uniprot.org/uniprot/D2HBY1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9646:FGF1 ^@ http://purl.uniprot.org/uniprot/D2GUK9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heparin-binding growth factors family.|||Cytoplasm|||Nucleus|||Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.|||Secreted|||cell cortex|||cytosol http://togogenome.org/gene/9646:LARS1 ^@ http://purl.uniprot.org/uniprot/G1MGU6 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9646:MEIS2 ^@ http://purl.uniprot.org/uniprot/A0A7N5KRA6|||http://purl.uniprot.org/uniprot/G1LQR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/9646:CCDC86 ^@ http://purl.uniprot.org/uniprot/D2I0J7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:CTNNBIP1 ^@ http://purl.uniprot.org/uniprot/G1LBW4 ^@ Similarity ^@ Belongs to the CTNNBIP1 family. http://togogenome.org/gene/9646:NTF4 ^@ http://purl.uniprot.org/uniprot/D2H7X3 ^@ Similarity ^@ Belongs to the NGF-beta family. http://togogenome.org/gene/9646:ATP1A3 ^@ http://purl.uniprot.org/uniprot/G1LDE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:LOC100475026 ^@ http://purl.uniprot.org/uniprot/D2I695 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:ISCA2 ^@ http://purl.uniprot.org/uniprot/G1MIX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HesB/IscA family.|||Mitochondrion http://togogenome.org/gene/9646:CENPI ^@ http://purl.uniprot.org/uniprot/D2I0B9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-I/CTF3 family.|||Nucleus|||centromere http://togogenome.org/gene/9646:PHC3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JM00|||http://purl.uniprot.org/uniprot/G1LDC6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:LOC100465694 ^@ http://purl.uniprot.org/uniprot/D2HWJ9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9646:SPTBN1 ^@ http://purl.uniprot.org/uniprot/G1LCP4|||http://purl.uniprot.org/uniprot/G1LCQ9 ^@ Similarity ^@ Belongs to the spectrin family. http://togogenome.org/gene/9646:NEDD9 ^@ http://purl.uniprot.org/uniprot/G1L7H1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAS family.|||focal adhesion http://togogenome.org/gene/9646:DPY30 ^@ http://purl.uniprot.org/uniprot/G1LMF2 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/9646:STON2 ^@ http://purl.uniprot.org/uniprot/A0A7N5P9P6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating.|||Belongs to the Stoned B family.|||Cytoplasm|||synaptosome http://togogenome.org/gene/9646:SRPRA ^@ http://purl.uniprot.org/uniprot/D2HV07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding SRP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:CCN5 ^@ http://purl.uniprot.org/uniprot/G1LBL0 ^@ Similarity ^@ Belongs to the CCN family. http://togogenome.org/gene/9646:SERPINB13 ^@ http://purl.uniprot.org/uniprot/D2H6Z9 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9646:AGRP ^@ http://purl.uniprot.org/uniprot/D2H9E8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9646:SNRPA ^@ http://purl.uniprot.org/uniprot/D2HMU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM U1 A/B'' family.|||Nucleus http://togogenome.org/gene/9646:VPS26A ^@ http://purl.uniprot.org/uniprot/A0A7N5K7U3 ^@ Similarity ^@ Belongs to the VPS26 family. http://togogenome.org/gene/9646:HMBOX1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JJ17 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:UBAP2L ^@ http://purl.uniprot.org/uniprot/A0A7N5K4M2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:CXCR5 ^@ http://purl.uniprot.org/uniprot/G1KZK8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:MSRB3 ^@ http://purl.uniprot.org/uniprot/A0A7N5K7V9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Binds 1 zinc ion per subunit.|||Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. http://togogenome.org/gene/9646:GLB1 ^@ http://purl.uniprot.org/uniprot/A0A7N5K226 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 35 family. http://togogenome.org/gene/9646:RHBDL2 ^@ http://purl.uniprot.org/uniprot/D2HXG7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S54 family.|||Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.|||Membrane http://togogenome.org/gene/9646:SLAIN2 ^@ http://purl.uniprot.org/uniprot/G1L8L6 ^@ Similarity ^@ Belongs to the SLAIN motif-containing family. http://togogenome.org/gene/9646:CZIB ^@ http://purl.uniprot.org/uniprot/G1LSL9 ^@ Similarity ^@ Belongs to the UPF0587 family. http://togogenome.org/gene/9646:TIMP3 ^@ http://purl.uniprot.org/uniprot/D2HHA6 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/9646:NUP93 ^@ http://purl.uniprot.org/uniprot/A0A7N5KEU7|||http://purl.uniprot.org/uniprot/D2GTW0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin interacting component (NIC) family.|||Nucleus membrane|||Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.|||nuclear pore complex http://togogenome.org/gene/9646:UBE4B ^@ http://purl.uniprot.org/uniprot/A0A7N5J9L3|||http://purl.uniprot.org/uniprot/G1LC99 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin conjugation factor E4 family.|||Cytoplasm|||The U-box domain is required for the ubiquitin protein ligase activity.|||Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. http://togogenome.org/gene/9646:SLC35B2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JIH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/9646:MNAT1 ^@ http://purl.uniprot.org/uniprot/D2GVS6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:SLC7A1 ^@ http://purl.uniprot.org/uniprot/D2H021 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:SEMA3G ^@ http://purl.uniprot.org/uniprot/G1LQJ5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the semaphorin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:GJA5 ^@ http://purl.uniprot.org/uniprot/D2HQ38 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9646:SLC25A45 ^@ http://purl.uniprot.org/uniprot/A0A7N5JZ06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9646:LOC100468877 ^@ http://purl.uniprot.org/uniprot/D2HZC3 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:ABCG5 ^@ http://purl.uniprot.org/uniprot/D2GU92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/9646:GNG7 ^@ http://purl.uniprot.org/uniprot/D2HTM6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9646:LTN1 ^@ http://purl.uniprot.org/uniprot/G1LNS1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LTN1 family.|||Component of the ribosome quality control complex (RQC).|||E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.|||cytosol http://togogenome.org/gene/9646:CFAP206 ^@ http://purl.uniprot.org/uniprot/D2HSL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP206 family.|||cilium axoneme http://togogenome.org/gene/9646:IL2 ^@ http://purl.uniprot.org/uniprot/H2DL90 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-2 family.|||Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.|||Secreted http://togogenome.org/gene/9646:DDRGK1 ^@ http://purl.uniprot.org/uniprot/G1LX14 ^@ Similarity ^@ Belongs to the DDRGK1 family. http://togogenome.org/gene/9646:SMAD2 ^@ http://purl.uniprot.org/uniprot/D2H8K9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:DIS3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JEU4 ^@ Similarity ^@ Belongs to the RNR ribonuclease family. http://togogenome.org/gene/9646:HEBP1 ^@ http://purl.uniprot.org/uniprot/G1LW27 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/9646:EDEM3 ^@ http://purl.uniprot.org/uniprot/D2HFM3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9646:SOAT1 ^@ http://purl.uniprot.org/uniprot/G1M7X8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:NSMCE1 ^@ http://purl.uniprot.org/uniprot/G1LBK8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NSE1 family.|||Component of the Smc5-Smc6 complex.|||Nucleus|||RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.|||telomere http://togogenome.org/gene/9646:SGSM2 ^@ http://purl.uniprot.org/uniprot/G1LM18 ^@ Similarity ^@ Belongs to the RUTBC family. http://togogenome.org/gene/9646:MYF6 ^@ http://purl.uniprot.org/uniprot/D2H510 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:ACRBP ^@ http://purl.uniprot.org/uniprot/D2HJ17 ^@ Subcellular Location Annotation ^@ acrosome http://togogenome.org/gene/9646:LOXL3 ^@ http://purl.uniprot.org/uniprot/D2HH53 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/9646:PRIMPOL ^@ http://purl.uniprot.org/uniprot/D2GY65 ^@ Similarity ^@ Belongs to the eukaryotic-type primase small subunit family. http://togogenome.org/gene/9646:FGD4 ^@ http://purl.uniprot.org/uniprot/A0A7N5KGR8 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9646:PPP4R3A ^@ http://purl.uniprot.org/uniprot/G1L480 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/9646:IL19 ^@ http://purl.uniprot.org/uniprot/A0A7N5JCE3|||http://purl.uniprot.org/uniprot/G1MGI7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/9646:ELAVL1 ^@ http://purl.uniprot.org/uniprot/D2HI97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM elav family.|||Cytoplasm http://togogenome.org/gene/9646:CDH5 ^@ http://purl.uniprot.org/uniprot/D2H9B3 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:UBA2 ^@ http://purl.uniprot.org/uniprot/D2HRQ5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ubiquitin-activating E1 family.|||Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.|||Nucleus http://togogenome.org/gene/9646:PHYHIP ^@ http://purl.uniprot.org/uniprot/D2H046 ^@ Similarity ^@ Belongs to the PHYHIP family. http://togogenome.org/gene/9646:HSD17B13 ^@ http://purl.uniprot.org/uniprot/G1L9A8 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9646:LECT2 ^@ http://purl.uniprot.org/uniprot/G1MHS8 ^@ Similarity ^@ Belongs to the LECT2/MIM-1 family. http://togogenome.org/gene/9646:ICOS ^@ http://purl.uniprot.org/uniprot/A0A7N5JDD1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.|||Homodimer; disulfide-linked.|||Membrane http://togogenome.org/gene/9646:TGIF1 ^@ http://purl.uniprot.org/uniprot/G1M1X3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:OSBPL6 ^@ http://purl.uniprot.org/uniprot/G1L214 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9646:DCK ^@ http://purl.uniprot.org/uniprot/G1LH94 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/9646:LOC100465045 ^@ http://purl.uniprot.org/uniprot/D2GV84 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:NTRK2 ^@ http://purl.uniprot.org/uniprot/A0A7N5K4R9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Membrane http://togogenome.org/gene/9646:EEF1AKMT1 ^@ http://purl.uniprot.org/uniprot/G1M856 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.|||Cytoplasm|||Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.|||Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure. http://togogenome.org/gene/9646:C5H15orf65 ^@ http://purl.uniprot.org/uniprot/A0A7N5KAD0 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.|||cilium axoneme http://togogenome.org/gene/9646:LOC100472805 ^@ http://purl.uniprot.org/uniprot/A0A7N5K4H0|||http://purl.uniprot.org/uniprot/A0A7N5KG27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:KCNA10 ^@ http://purl.uniprot.org/uniprot/D2HZL8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:CLIC2 ^@ http://purl.uniprot.org/uniprot/G1LR82 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/9646:CCND3 ^@ http://purl.uniprot.org/uniprot/D2GZE8 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9646:PNKD ^@ http://purl.uniprot.org/uniprot/G1L8N7 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. http://togogenome.org/gene/9646:TPPP ^@ http://purl.uniprot.org/uniprot/D2HVI1 ^@ Similarity ^@ Belongs to the TPPP family. http://togogenome.org/gene/9646:CNIH1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KGJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/9646:LOC100481641 ^@ http://purl.uniprot.org/uniprot/D2I509 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:DISP3 ^@ http://purl.uniprot.org/uniprot/D2HKB1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:MAP2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JBJ7 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9646:CLCA2 ^@ http://purl.uniprot.org/uniprot/D2HBX7 ^@ Similarity ^@ Belongs to the CLCR family. http://togogenome.org/gene/9646:LOC100468789 ^@ http://purl.uniprot.org/uniprot/G1M0K6 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9646:TMED5 ^@ http://purl.uniprot.org/uniprot/D2H826 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9646:LOC100465298 ^@ http://purl.uniprot.org/uniprot/D2HTX3 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9646:MTCP1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JC46 ^@ Similarity ^@ Belongs to the TCL1 family. http://togogenome.org/gene/9646:NDUFB4 ^@ http://purl.uniprot.org/uniprot/A0A7N5KEF1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB4 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:ATP6V0A1 ^@ http://purl.uniprot.org/uniprot/D2HIT6|||http://purl.uniprot.org/uniprot/G1LIT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/9646:PPP4C ^@ http://purl.uniprot.org/uniprot/D2HX48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/9646:GNPNAT1 ^@ http://purl.uniprot.org/uniprot/D2I275 ^@ Similarity|||Subunit ^@ Belongs to the acetyltransferase family. GNA1 subfamily.|||Homodimer. http://togogenome.org/gene/9646:NUP85 ^@ http://purl.uniprot.org/uniprot/G1LRL9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nucleoporin Nup85 family.|||Component of the nuclear pore complex (NPC).|||Functions as a component of the nuclear pore complex (NPC).|||Nucleus membrane|||nuclear pore complex http://togogenome.org/gene/9646:CA14 ^@ http://purl.uniprot.org/uniprot/A0A7N5JRI4 ^@ Similarity ^@ Belongs to the alpha-carbonic anhydrase family. http://togogenome.org/gene/9646:AGT ^@ http://purl.uniprot.org/uniprot/G1LT19 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the serpin family.|||Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.|||Secreted|||Stimulates aldosterone release. http://togogenome.org/gene/9646:TSN ^@ http://purl.uniprot.org/uniprot/G1LEL4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the translin family.|||DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.|||Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.|||Nucleus|||Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring. http://togogenome.org/gene/9646:LOC100470899 ^@ http://purl.uniprot.org/uniprot/D2I1T4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:ZDHHC9 ^@ http://purl.uniprot.org/uniprot/G1M953 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9646:LIG4 ^@ http://purl.uniprot.org/uniprot/D2H2R3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent DNA ligase family.|||Nucleus http://togogenome.org/gene/9646:RPS19BP1 ^@ http://purl.uniprot.org/uniprot/D2GZL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AROS family.|||nucleolus http://togogenome.org/gene/9646:ENPP3 ^@ http://purl.uniprot.org/uniprot/G1LVA2 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9646:PSMD12 ^@ http://purl.uniprot.org/uniprot/A0A7N5JFP7 ^@ Similarity ^@ Belongs to the proteasome subunit p55 family. http://togogenome.org/gene/9646:MRRF ^@ http://purl.uniprot.org/uniprot/G1L1P2 ^@ Function|||Similarity ^@ Belongs to the RRF family.|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/9646:B3GALT4 ^@ http://purl.uniprot.org/uniprot/D2GZ00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:CCK ^@ http://purl.uniprot.org/uniprot/D2HN41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gastrin/cholecystokinin family.|||Secreted http://togogenome.org/gene/9646:EXOC1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KCD9|||http://purl.uniprot.org/uniprot/A0A7N5KRD5|||http://purl.uniprot.org/uniprot/D2H8I0|||http://purl.uniprot.org/uniprot/G1LNU1 ^@ Similarity ^@ Belongs to the SEC3 family. http://togogenome.org/gene/9646:SLC18A3 ^@ http://purl.uniprot.org/uniprot/D2HWL3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:UBA7 ^@ http://purl.uniprot.org/uniprot/G1M0R6 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/9646:TRMT1L ^@ http://purl.uniprot.org/uniprot/D2HFM6|||http://purl.uniprot.org/uniprot/G1M4N2 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.|||May play a role in motor coordination and exploratory behavior. http://togogenome.org/gene/9646:ALG8 ^@ http://purl.uniprot.org/uniprot/D2H3T6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG6/ALG8 glucosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:L3MBTL3 ^@ http://purl.uniprot.org/uniprot/D2HLX1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:LOC100464584 ^@ http://purl.uniprot.org/uniprot/G1MKN6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:CAMK2D ^@ http://purl.uniprot.org/uniprot/A0A7N5P4S6|||http://purl.uniprot.org/uniprot/G1LRN5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9646:VIP ^@ http://purl.uniprot.org/uniprot/G1LWI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/9646:RNF31 ^@ http://purl.uniprot.org/uniprot/D2HG54|||http://purl.uniprot.org/uniprot/G1MD78 ^@ Similarity ^@ Belongs to the RBR family. http://togogenome.org/gene/9646:PSMB6 ^@ http://purl.uniprot.org/uniprot/G1MCA5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:RPL23 ^@ http://purl.uniprot.org/uniprot/F2X264 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/9646:MAPK6 ^@ http://purl.uniprot.org/uniprot/D2HN70 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9646:OLFML3 ^@ http://purl.uniprot.org/uniprot/G1L907 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:HSPB8 ^@ http://purl.uniprot.org/uniprot/D2HCN6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Cytoplasm|||Displays temperature-dependent chaperone activity.|||Nucleus http://togogenome.org/gene/9646:CASP14 ^@ http://purl.uniprot.org/uniprot/G1L6V2 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9646:UBL3 ^@ http://purl.uniprot.org/uniprot/G1LQM0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9646:PHACTR4 ^@ http://purl.uniprot.org/uniprot/A0A7N5KMV8|||http://purl.uniprot.org/uniprot/G1LXV4|||http://purl.uniprot.org/uniprot/G1LXW0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin.|||Cytoplasm|||Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway.|||lamellipodium http://togogenome.org/gene/9646:RPS15 ^@ http://purl.uniprot.org/uniprot/B5KKL3 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS19 family.|||Component of the small ribosomal subunit. http://togogenome.org/gene/9646:NUBP2 ^@ http://purl.uniprot.org/uniprot/G1LP85 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.|||Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.|||Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.|||Cytoplasm|||Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.|||Nucleus|||centrosome http://togogenome.org/gene/9646:RPS17 ^@ http://purl.uniprot.org/uniprot/D3YBZ9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/9646:CENPT ^@ http://purl.uniprot.org/uniprot/G1MGP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-T/CNN1 family.|||Nucleus|||kinetochore http://togogenome.org/gene/9646:IP6K2 ^@ http://purl.uniprot.org/uniprot/G1L0Z4 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9646:DKK1 ^@ http://purl.uniprot.org/uniprot/D2HH81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/9646:DNASE1L1 ^@ http://purl.uniprot.org/uniprot/A0A7N5K9T8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNase I family.|||Nucleus envelope|||Zymogen granule http://togogenome.org/gene/9646:ATP6V1E1 ^@ http://purl.uniprot.org/uniprot/G1MGJ9 ^@ Similarity ^@ Belongs to the V-ATPase E subunit family. http://togogenome.org/gene/9646:RAG2 ^@ http://purl.uniprot.org/uniprot/D2HV50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAG2 family.|||Nucleus http://togogenome.org/gene/9646:LOC100471425 ^@ http://purl.uniprot.org/uniprot/G1LLL8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 35 family. http://togogenome.org/gene/9646:LOC100467890 ^@ http://purl.uniprot.org/uniprot/D2I7P4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:LOC100484936 ^@ http://purl.uniprot.org/uniprot/A0A7N5P5V2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9646:SNAP25 ^@ http://purl.uniprot.org/uniprot/A0A7N5JME4|||http://purl.uniprot.org/uniprot/G1LAD3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNAP-25 family.|||Cell membrane|||Membrane|||Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.|||Photoreceptor inner segment|||synaptosome|||t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. http://togogenome.org/gene/9646:ZDHHC22 ^@ http://purl.uniprot.org/uniprot/G1MJ71 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9646:GALNT5 ^@ http://purl.uniprot.org/uniprot/G1M739 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:CSF2RB ^@ http://purl.uniprot.org/uniprot/G1LTB8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:POLR3C ^@ http://purl.uniprot.org/uniprot/A0A7N5KME8|||http://purl.uniprot.org/uniprot/G1MGP1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/9646:CTNND1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KM95 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/9646:LOC100473409 ^@ http://purl.uniprot.org/uniprot/D2I6L9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:LOC100480798 ^@ http://purl.uniprot.org/uniprot/D2I7M4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:DTD2 ^@ http://purl.uniprot.org/uniprot/D2H9M3 ^@ Similarity ^@ Belongs to the DTD family. http://togogenome.org/gene/9646:MTFR1L ^@ http://purl.uniprot.org/uniprot/G1LUR0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission. http://togogenome.org/gene/9646:OSBPL8 ^@ http://purl.uniprot.org/uniprot/G1LJ33|||http://purl.uniprot.org/uniprot/G1LJ35 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9646:TNS4 ^@ http://purl.uniprot.org/uniprot/D2HR24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTEN phosphatase protein family.|||focal adhesion http://togogenome.org/gene/9646:SLC28A3 ^@ http://purl.uniprot.org/uniprot/G1LBC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Membrane http://togogenome.org/gene/9646:MAP3K7 ^@ http://purl.uniprot.org/uniprot/A0A7N5JGB4|||http://purl.uniprot.org/uniprot/D2HRF5 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation.|||Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Cytoplasm http://togogenome.org/gene/9646:LOC100470813 ^@ http://purl.uniprot.org/uniprot/D2I2B9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9646:BMP5 ^@ http://purl.uniprot.org/uniprot/D2HAN3 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9646:RAB39B ^@ http://purl.uniprot.org/uniprot/D2I6G0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:GYS2 ^@ http://purl.uniprot.org/uniprot/D2I1F2 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase 3 family.|||Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. http://togogenome.org/gene/9646:APTX ^@ http://purl.uniprot.org/uniprot/A0A7N5KGT1 ^@ Subcellular Location Annotation ^@ nucleolus|||nucleoplasm http://togogenome.org/gene/9646:EMP3 ^@ http://purl.uniprot.org/uniprot/D2H802 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Probably involved in cell proliferation and cell-cell interactions. http://togogenome.org/gene/9646:LOC100476803 ^@ http://purl.uniprot.org/uniprot/G1MKN9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:EFNB2 ^@ http://purl.uniprot.org/uniprot/G1LC70 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:CCR9 ^@ http://purl.uniprot.org/uniprot/A0A7N5JVH1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:SLC23A2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JEP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.|||Membrane http://togogenome.org/gene/9646:BORCS5 ^@ http://purl.uniprot.org/uniprot/A0A7N5JU16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS5 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9646:RAB3IL1 ^@ http://purl.uniprot.org/uniprot/A0A7N5K7B0 ^@ Similarity ^@ Belongs to the SEC2 family. http://togogenome.org/gene/9646:TNKS ^@ http://purl.uniprot.org/uniprot/G1LHI1 ^@ Function|||Similarity ^@ Belongs to the ARTD/PARP family.|||Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation. http://togogenome.org/gene/9646:IL1R2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JIR1|||http://purl.uniprot.org/uniprot/G1M392 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9646:TMEM50A ^@ http://purl.uniprot.org/uniprot/A0A7N5JWR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane http://togogenome.org/gene/9646:STAT2 ^@ http://purl.uniprot.org/uniprot/D2H356 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:SMC1A ^@ http://purl.uniprot.org/uniprot/D2HVV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC1 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/9646:HARBI1 ^@ http://purl.uniprot.org/uniprot/D2HHI7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HARBI1 family.|||Cytoplasm|||Nucleus|||Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity. http://togogenome.org/gene/9646:NXPE3 ^@ http://purl.uniprot.org/uniprot/G1LAJ0 ^@ Similarity ^@ Belongs to the NXPE family. http://togogenome.org/gene/9646:HSCB ^@ http://purl.uniprot.org/uniprot/A0A7N5JFF1|||http://purl.uniprot.org/uniprot/A0A7N5P846|||http://purl.uniprot.org/uniprot/G1LPD9 ^@ Similarity ^@ Belongs to the HscB family. http://togogenome.org/gene/9646:USP1 ^@ http://purl.uniprot.org/uniprot/D2H7G9 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9646:CFB ^@ http://purl.uniprot.org/uniprot/D2I358 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9646:ASIC4 ^@ http://purl.uniprot.org/uniprot/G1MEM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.|||Membrane http://togogenome.org/gene/9646:CCN3 ^@ http://purl.uniprot.org/uniprot/D2I2V9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9646:TMEM115 ^@ http://purl.uniprot.org/uniprot/D2HES1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:GABRG1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KNE9|||http://purl.uniprot.org/uniprot/G1MC80 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9646:LOC100476647 ^@ http://purl.uniprot.org/uniprot/G1M580 ^@ Similarity ^@ Belongs to the GroES chaperonin family. http://togogenome.org/gene/9646:PINLYP ^@ http://purl.uniprot.org/uniprot/G1LCA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNF-like-inhibitor family.|||Secreted http://togogenome.org/gene/9646:TM7SF2 ^@ http://purl.uniprot.org/uniprot/D2H4R3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Membrane http://togogenome.org/gene/9646:FEZ1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KKM0|||http://purl.uniprot.org/uniprot/G1L2B6 ^@ Similarity ^@ Belongs to the zygin family. http://togogenome.org/gene/9646:PAQR3 ^@ http://purl.uniprot.org/uniprot/D2GUG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9646:PPM1B ^@ http://purl.uniprot.org/uniprot/A0A7N5JBX3|||http://purl.uniprot.org/uniprot/D2GU95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PP2C family.|||Membrane|||cytosol http://togogenome.org/gene/9646:BMPR2 ^@ http://purl.uniprot.org/uniprot/G1M3F0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. http://togogenome.org/gene/9646:CHMP4C ^@ http://purl.uniprot.org/uniprot/D2H4W1 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9646:MRPL42 ^@ http://purl.uniprot.org/uniprot/G1LTC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL42 family.|||Mitochondrion http://togogenome.org/gene/9646:CASQ2 ^@ http://purl.uniprot.org/uniprot/D2HS21 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calsequestrin family.|||Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.|||Sarcoplasmic reticulum lumen http://togogenome.org/gene/9646:TTC38 ^@ http://purl.uniprot.org/uniprot/G1L9H6 ^@ Similarity ^@ Belongs to the TTC38 family. http://togogenome.org/gene/9646:UPF3B ^@ http://purl.uniprot.org/uniprot/D2HJS9|||http://purl.uniprot.org/uniprot/G1KZX9 ^@ Similarity ^@ Belongs to the RENT3 family. http://togogenome.org/gene/9646:TRAF5 ^@ http://purl.uniprot.org/uniprot/D2H652 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:POLR3F ^@ http://purl.uniprot.org/uniprot/G1LF40 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/9646:FAM151B ^@ http://purl.uniprot.org/uniprot/G1MB76 ^@ Similarity ^@ Belongs to the FAM151 family. http://togogenome.org/gene/9646:ANXA1 ^@ http://purl.uniprot.org/uniprot/G1MAP8 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Basolateral cell membrane|||Belongs to the annexin family.|||Cell membrane|||Early endosome|||Endosome|||Lateral cell membrane|||Membrane|||Nucleus|||The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.|||cilium|||extracellular exosome|||extracellular space|||phagocytic cup|||secretory vesicle lumen http://togogenome.org/gene/9646:METAP1D ^@ http://purl.uniprot.org/uniprot/A0A7N5KF98 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/9646:EEF1D ^@ http://purl.uniprot.org/uniprot/D2HIP6 ^@ Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family. http://togogenome.org/gene/9646:PHF10 ^@ http://purl.uniprot.org/uniprot/A0A7N5JKE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAYP family.|||Nucleus http://togogenome.org/gene/9646:EFNA1 ^@ http://purl.uniprot.org/uniprot/D2HJM2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:FDPS ^@ http://purl.uniprot.org/uniprot/A0A7N5P1A6 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9646:HSPH1 ^@ http://purl.uniprot.org/uniprot/D2H013|||http://purl.uniprot.org/uniprot/G1LQF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 70 family.|||Cytoplasm http://togogenome.org/gene/9646:CHD9 ^@ http://purl.uniprot.org/uniprot/A0A7N5KLU4 ^@ Similarity ^@ Belongs to the SNF2/RAD54 helicase family. http://togogenome.org/gene/9646:PRPF38A ^@ http://purl.uniprot.org/uniprot/G1LRX0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PRP38 family.|||Component of the spliceosome B complex.|||Involved in pre-mRNA splicing as a component of the spliceosome.|||Nucleus http://togogenome.org/gene/9646:GUCA2A ^@ http://purl.uniprot.org/uniprot/G1L184 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylin family.|||Secreted http://togogenome.org/gene/9646:UCP1 ^@ http://purl.uniprot.org/uniprot/D2HWA3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||May undergo ubiquitin-mediated proteasomal degradation.|||Membrane|||Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:NDUFB3 ^@ http://purl.uniprot.org/uniprot/D2H2Q3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB3 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:PARD6A ^@ http://purl.uniprot.org/uniprot/D2H9F1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAR6 family.|||Cytoplasm|||tight junction http://togogenome.org/gene/9646:TTC25 ^@ http://purl.uniprot.org/uniprot/G1LH18 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9646:LRTOMT ^@ http://purl.uniprot.org/uniprot/G1LWE8 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. http://togogenome.org/gene/9646:AZIN1 ^@ http://purl.uniprot.org/uniprot/G1M879 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/9646:ZBED1 ^@ http://purl.uniprot.org/uniprot/D2HFI5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:SMU1 ^@ http://purl.uniprot.org/uniprot/G1LM04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SMU1 family.|||Nucleus speckle http://togogenome.org/gene/9646:LOC100480184 ^@ http://purl.uniprot.org/uniprot/D2HK73 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:SAMM50 ^@ http://purl.uniprot.org/uniprot/A0A7N5KK34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAM50/omp85 family.|||Mitochondrion outer membrane http://togogenome.org/gene/9646:ACSM3 ^@ http://purl.uniprot.org/uniprot/D2HXR0 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9646:EBF1 ^@ http://purl.uniprot.org/uniprot/G1LIN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COE family.|||Nucleus http://togogenome.org/gene/9646:EDN2 ^@ http://purl.uniprot.org/uniprot/G1L102 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Secreted http://togogenome.org/gene/9646:DDX52 ^@ http://purl.uniprot.org/uniprot/G1M3J1 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily. http://togogenome.org/gene/9646:LOC100484125 ^@ http://purl.uniprot.org/uniprot/G1MPL1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCC3 family.|||Membrane|||Mitochondrion inner membrane|||Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology. http://togogenome.org/gene/9646:LOC100474336 ^@ http://purl.uniprot.org/uniprot/G1MP21 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:LOC100469120 ^@ http://purl.uniprot.org/uniprot/A0A7N5P1E8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cystatin family.|||Secreted http://togogenome.org/gene/9646:XCR1 ^@ http://purl.uniprot.org/uniprot/D2GV80 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:TMEM45B ^@ http://purl.uniprot.org/uniprot/D2GUX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/9646:TMEM70 ^@ http://purl.uniprot.org/uniprot/G1M2G9 ^@ Similarity ^@ Belongs to the TMEM70 family. http://togogenome.org/gene/9646:ALOX5 ^@ http://purl.uniprot.org/uniprot/D2HUH1 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the lipoxygenase family.|||Binds 1 Fe cation per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:ELOF1 ^@ http://purl.uniprot.org/uniprot/D2I6N2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELOF1 family.|||Nucleus|||Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. http://togogenome.org/gene/9646:EZH1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KE59 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:XPC ^@ http://purl.uniprot.org/uniprot/G1LS59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPC family.|||Nucleus http://togogenome.org/gene/9646:SELENOS ^@ http://purl.uniprot.org/uniprot/G1LKM6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the selenoprotein S family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.|||Membrane http://togogenome.org/gene/9646:B3GALT5 ^@ http://purl.uniprot.org/uniprot/D2HZR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:SERPINA4 ^@ http://purl.uniprot.org/uniprot/G1LII5 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9646:MTERF4 ^@ http://purl.uniprot.org/uniprot/G1ME26 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/9646:GPR182 ^@ http://purl.uniprot.org/uniprot/D2H369 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:TPD52L1 ^@ http://purl.uniprot.org/uniprot/A0A7N5K7A1 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/9646:PRDM10 ^@ http://purl.uniprot.org/uniprot/G1L6P2 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9646:HAT1 ^@ http://purl.uniprot.org/uniprot/G1LPG0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HAT1 family.|||Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.|||Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac). http://togogenome.org/gene/9646:LOC100481892 ^@ http://purl.uniprot.org/uniprot/D2I658 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:RHOT1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JC54|||http://purl.uniprot.org/uniprot/A0A7N5JXF5|||http://purl.uniprot.org/uniprot/A0A7N5P042|||http://purl.uniprot.org/uniprot/G1LG95 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial Rho GTPase family.|||Membrane|||Mitochondrial GTPase involved in mitochondrial trafficking.|||Mitochondrion outer membrane http://togogenome.org/gene/9646:TGIF2 ^@ http://purl.uniprot.org/uniprot/D2H465 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:INSIG2 ^@ http://purl.uniprot.org/uniprot/G1M1N7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INSIG family.|||Endoplasmic reticulum membrane|||Mediates feedback control of cholesterol synthesis.|||Membrane http://togogenome.org/gene/9646:STAT4 ^@ http://purl.uniprot.org/uniprot/A0A7N5PAF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:NRDC ^@ http://purl.uniprot.org/uniprot/G1LRA6 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/9646:L3MBTL2 ^@ http://purl.uniprot.org/uniprot/G1M634 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Nucleus|||Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, BAT8 and YAF2.|||Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. http://togogenome.org/gene/9646:C1H3orf70 ^@ http://purl.uniprot.org/uniprot/D2H297 ^@ Similarity ^@ Belongs to the UPF0524 family. http://togogenome.org/gene/9646:THG1L ^@ http://purl.uniprot.org/uniprot/D2GUI2 ^@ Cofactor|||Similarity ^@ Belongs to the tRNA(His) guanylyltransferase family.|||Binds 2 magnesium ions per subunit. http://togogenome.org/gene/9646:DCTPP1 ^@ http://purl.uniprot.org/uniprot/G1LML2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Homotetramer.|||Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.|||cytosol http://togogenome.org/gene/9646:DDX43 ^@ http://purl.uniprot.org/uniprot/G1LMN7 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9646:HDAC6 ^@ http://purl.uniprot.org/uniprot/G1M1M5 ^@ Similarity ^@ Belongs to the histone deacetylase family. HD type 2 subfamily. http://togogenome.org/gene/9646:RIOK1 ^@ http://purl.uniprot.org/uniprot/G1MG84 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/9646:NAA10 ^@ http://purl.uniprot.org/uniprot/G1MJH5 ^@ Similarity ^@ Belongs to the acetyltransferase family. ARD1 subfamily. http://togogenome.org/gene/9646:XRCC1 ^@ http://purl.uniprot.org/uniprot/D2HNF1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:KEG54_p09 ^@ http://purl.uniprot.org/uniprot/A5JFK0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase protein 8 family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with PRICKLE3.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion membrane http://togogenome.org/gene/9646:LOC100477672 ^@ http://purl.uniprot.org/uniprot/D2HVS8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9646:SFR1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JI35|||http://purl.uniprot.org/uniprot/G1MI37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SFR1/MEI5 family.|||Nucleus http://togogenome.org/gene/9646:DPYSL4 ^@ http://purl.uniprot.org/uniprot/G1LWE1 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/9646:MMP8 ^@ http://purl.uniprot.org/uniprot/G1LUC1 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9646:DARS2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JWJ3 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. http://togogenome.org/gene/9646:YIF1A ^@ http://purl.uniprot.org/uniprot/G1MFG1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIF1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Has a role in transport between endoplasmic reticulum and Golgi.|||Membrane http://togogenome.org/gene/9646:SARAF ^@ http://purl.uniprot.org/uniprot/A0A7N5JAN9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SARAF family.|||Endoplasmic reticulum membrane|||Interacts with STIM1; the interaction is inhibit by th interaction of STIM1 with EFHB.|||Membrane|||Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions. http://togogenome.org/gene/9646:LOC100474694 ^@ http://purl.uniprot.org/uniprot/D2H366 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9646:SLC20A2 ^@ http://purl.uniprot.org/uniprot/D2H978 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter. http://togogenome.org/gene/9646:LMX1B ^@ http://purl.uniprot.org/uniprot/A0A7N5K9U4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:SEMA4F ^@ http://purl.uniprot.org/uniprot/A0A7N5JQS7|||http://purl.uniprot.org/uniprot/A0A7N5KLW9|||http://purl.uniprot.org/uniprot/D2HH51 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:CPEB4 ^@ http://purl.uniprot.org/uniprot/A0A7N5K4R5|||http://purl.uniprot.org/uniprot/A0A7N5KAC3|||http://purl.uniprot.org/uniprot/A0A7N5P9R6|||http://purl.uniprot.org/uniprot/D2H5F8 ^@ Similarity ^@ Belongs to the RRM CPEB family. http://togogenome.org/gene/9646:P2RY4 ^@ http://purl.uniprot.org/uniprot/D2H897 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:ATP11C ^@ http://purl.uniprot.org/uniprot/A0A7N5KLC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9646:IK ^@ http://purl.uniprot.org/uniprot/G1LWN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RED family.|||Nucleus http://togogenome.org/gene/9646:CACNG4 ^@ http://purl.uniprot.org/uniprot/D2HQ98 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane|||Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. http://togogenome.org/gene/9646:MBOAT4 ^@ http://purl.uniprot.org/uniprot/G1L3V3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:UPF2 ^@ http://purl.uniprot.org/uniprot/D2HRM0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:CORO1A ^@ http://purl.uniprot.org/uniprot/D2HX51 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat coronin family.|||Binds actin.|||Membrane|||cell cortex|||cytoskeleton|||phagosome membrane http://togogenome.org/gene/9646:SMG6 ^@ http://purl.uniprot.org/uniprot/G1LM72 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini.|||Plays a role in nonsense-mediated mRNA decay.|||The PINc domain confers endonuclease activity and is expected to bind the catalytic metal ion.|||cytosol|||nucleolus|||telomere http://togogenome.org/gene/9646:CAVIN3 ^@ http://purl.uniprot.org/uniprot/D2HR67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/9646:PPME1 ^@ http://purl.uniprot.org/uniprot/G1MFP8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the AB hydrolase superfamily.|||Binds PPP2CA and PPP2CB.|||Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. http://togogenome.org/gene/9646:SLC39A14 ^@ http://purl.uniprot.org/uniprot/D2H043 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:EIF1 ^@ http://purl.uniprot.org/uniprot/D2Y399 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/9646:RAB18 ^@ http://purl.uniprot.org/uniprot/G1MC16 ^@ Subcellular Location Annotation ^@ Apical cell membrane|||Cell membrane|||Lipid droplet http://togogenome.org/gene/9646:LOC100464640 ^@ http://purl.uniprot.org/uniprot/G1LMS4 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9646:MYOZ1 ^@ http://purl.uniprot.org/uniprot/G1MEL2 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/9646:TOM1L2 ^@ http://purl.uniprot.org/uniprot/G1LES4 ^@ Similarity ^@ Belongs to the TOM1 family. http://togogenome.org/gene/9646:RBKS ^@ http://purl.uniprot.org/uniprot/G1L2V0 ^@ Activity Regulation|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Belongs to the carbohydrate kinase pfkB family.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Nucleus|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/9646:PPIP5K1 ^@ http://purl.uniprot.org/uniprot/G1M9Y7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histidine acid phosphatase family. VIP1 subfamily.|||Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).|||cytosol http://togogenome.org/gene/9646:PLXNA2 ^@ http://purl.uniprot.org/uniprot/G1LNL6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the plexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:CDH18 ^@ http://purl.uniprot.org/uniprot/G1LMB4 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:SIX2 ^@ http://purl.uniprot.org/uniprot/D2GUA0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:RMND1 ^@ http://purl.uniprot.org/uniprot/G1LX60 ^@ Similarity ^@ Belongs to the RMD1/sif2 family. http://togogenome.org/gene/9646:SQLE ^@ http://purl.uniprot.org/uniprot/D2HFA5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the squalene monooxygenase family.|||Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9646:G6PC3 ^@ http://purl.uniprot.org/uniprot/D2HCU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9646:LOC100482711 ^@ http://purl.uniprot.org/uniprot/D2HW23 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:MAPK9 ^@ http://purl.uniprot.org/uniprot/D2HY90 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/9646:AQP6 ^@ http://purl.uniprot.org/uniprot/G1L2M7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:PES1 ^@ http://purl.uniprot.org/uniprot/A0A7N5K9I3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pescadillo family.|||Chromosome|||Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome. Interacts with IRS1 and UBTF. May interact with MAP1B.|||Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.|||Sumoylated.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9646:IL12RB2 ^@ http://purl.uniprot.org/uniprot/G1LD64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/9646:ID3 ^@ http://purl.uniprot.org/uniprot/D2GWC3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:ORC5 ^@ http://purl.uniprot.org/uniprot/G1LGP5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:HCRTR2 ^@ http://purl.uniprot.org/uniprot/D2HL74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:ELF1 ^@ http://purl.uniprot.org/uniprot/G1LPY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9646:KDM4C ^@ http://purl.uniprot.org/uniprot/A0A7N5JQL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JHDM3 histone demethylase family.|||Nucleus http://togogenome.org/gene/9646:DNAJC16 ^@ http://purl.uniprot.org/uniprot/D2HH14 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Plays an important role in regulating the size of autophagosomes during the formation process. http://togogenome.org/gene/9646:SNX1 ^@ http://purl.uniprot.org/uniprot/G1L6V9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome membrane|||Endosome membrane|||Membrane|||lamellipodium|||trans-Golgi network membrane http://togogenome.org/gene/9646:SGTB ^@ http://purl.uniprot.org/uniprot/G1LXL2 ^@ Similarity ^@ Belongs to the SGT family. http://togogenome.org/gene/9646:PTMA ^@ http://purl.uniprot.org/uniprot/E7CYG5 ^@ Similarity ^@ Belongs to the pro/parathymosin family. http://togogenome.org/gene/9646:ABCD1 ^@ http://purl.uniprot.org/uniprot/G1LQ34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9646:ENO3 ^@ http://purl.uniprot.org/uniprot/D2I1K4|||http://purl.uniprot.org/uniprot/G1LIG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/9646:BRMS1L ^@ http://purl.uniprot.org/uniprot/G1MB84 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:IRGC ^@ http://purl.uniprot.org/uniprot/D2HNE5 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. http://togogenome.org/gene/9646:SLC16A2 ^@ http://purl.uniprot.org/uniprot/G1L7X1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:CD53 ^@ http://purl.uniprot.org/uniprot/G1LVB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9646:LOC100471209 ^@ http://purl.uniprot.org/uniprot/A0A7N5JX83 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9646:HOXB1 ^@ http://purl.uniprot.org/uniprot/D2H564 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Labial subfamily.|||Nucleus http://togogenome.org/gene/9646:UBAP2 ^@ http://purl.uniprot.org/uniprot/G1L0K6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:DYRK4 ^@ http://purl.uniprot.org/uniprot/G1MB05 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. http://togogenome.org/gene/9646:HNRNPF ^@ http://purl.uniprot.org/uniprot/D2H6F1 ^@ Subcellular Location Annotation ^@ nucleoplasm http://togogenome.org/gene/9646:CHUK ^@ http://purl.uniprot.org/uniprot/G1LK22 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9646:FAM83B ^@ http://purl.uniprot.org/uniprot/G1MGE6 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9646:EDNRA ^@ http://purl.uniprot.org/uniprot/D2H5I9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with HDAC7 and KAT5.|||Membrane|||Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. http://togogenome.org/gene/9646:LOC100475916 ^@ http://purl.uniprot.org/uniprot/D2HZD5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:CRY1 ^@ http://purl.uniprot.org/uniprot/D2HXW9 ^@ Cofactor|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/9646:STRA6 ^@ http://purl.uniprot.org/uniprot/D2HKZ5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9646:TMEM175 ^@ http://purl.uniprot.org/uniprot/A0A7N5KBT4|||http://purl.uniprot.org/uniprot/D2HPR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM175 family.|||Membrane http://togogenome.org/gene/9646:MPHOSPH10 ^@ http://purl.uniprot.org/uniprot/D2HNY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MPP10 family.|||nucleolus http://togogenome.org/gene/9646:TPK1 ^@ http://purl.uniprot.org/uniprot/G1LPU3 ^@ Similarity ^@ Belongs to the thiamine pyrophosphokinase family. http://togogenome.org/gene/9646:CLDN11 ^@ http://purl.uniprot.org/uniprot/D2HFL7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9646:LOC100471070 ^@ http://purl.uniprot.org/uniprot/D2I755 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9646:SPAM1 ^@ http://purl.uniprot.org/uniprot/G1LD44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 56 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:TPPP2 ^@ http://purl.uniprot.org/uniprot/G1LIZ2 ^@ Similarity ^@ Belongs to the TPPP family. http://togogenome.org/gene/9646:PLK2 ^@ http://purl.uniprot.org/uniprot/D2H938 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. http://togogenome.org/gene/9646:TMEM129 ^@ http://purl.uniprot.org/uniprot/G1MEU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM129 family.|||Membrane http://togogenome.org/gene/9646:CSE1L ^@ http://purl.uniprot.org/uniprot/G1M575 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPO2/CSE1 family.|||Cytoplasm http://togogenome.org/gene/9646:ERAL1 ^@ http://purl.uniprot.org/uniprot/D2GU20 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.|||Mitochondrion inner membrane|||Mitochondrion matrix|||Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly (By similarity). http://togogenome.org/gene/9646:ALDH6A1 ^@ http://purl.uniprot.org/uniprot/G1MIX0 ^@ Function|||Similarity ^@ Belongs to the aldehyde dehydrogenase family.|||Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA. http://togogenome.org/gene/9646:YARS2 ^@ http://purl.uniprot.org/uniprot/D2H4J9 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9646:TMED10 ^@ http://purl.uniprot.org/uniprot/D2GZX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:DDIT4 ^@ http://purl.uniprot.org/uniprot/D2HZB2 ^@ Similarity ^@ Belongs to the DDIT4 family. http://togogenome.org/gene/9646:ALDOB ^@ http://purl.uniprot.org/uniprot/D2HV23 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/9646:CRYBA4 ^@ http://purl.uniprot.org/uniprot/A0A7N5JYN6 ^@ Function|||Similarity ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens. http://togogenome.org/gene/9646:LPAR2 ^@ http://purl.uniprot.org/uniprot/D2GV63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:TMCC2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JE38 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/9646:EPHA1 ^@ http://purl.uniprot.org/uniprot/G1LJW7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:HTR2C ^@ http://purl.uniprot.org/uniprot/A0A7N5K7X2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:LHFPL6 ^@ http://purl.uniprot.org/uniprot/G1M2I6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:ING3 ^@ http://purl.uniprot.org/uniprot/G1LHC7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9646:RPL18A ^@ http://purl.uniprot.org/uniprot/D7RAF5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL20 family. http://togogenome.org/gene/9646:LOC100474844 ^@ http://purl.uniprot.org/uniprot/G1MP24 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:NHP2 ^@ http://purl.uniprot.org/uniprot/D2HNR8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/9646:SLC39A7 ^@ http://purl.uniprot.org/uniprot/D2GZ05 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:LOC100465804 ^@ http://purl.uniprot.org/uniprot/G1MK93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:LOC100472013 ^@ http://purl.uniprot.org/uniprot/D2HDV4|||http://purl.uniprot.org/uniprot/P18970 ^@ Function|||Similarity|||Subunit|||Tissue Specificity ^@ Belongs to the globin family.|||Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1. Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.|||Heterotetramer of two alpha chains and two beta chains.|||Involved in oxygen transport from the lung to the various peripheral tissues.|||Red blood cells. http://togogenome.org/gene/9646:GTF2I ^@ http://purl.uniprot.org/uniprot/G1M9V8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:PPT1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JR14 ^@ Similarity ^@ Belongs to the palmitoyl-protein thioesterase family. http://togogenome.org/gene/9646:RPL3 ^@ http://purl.uniprot.org/uniprot/F2X234 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/9646:ABHD6 ^@ http://purl.uniprot.org/uniprot/A0A7N5KP14 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family. http://togogenome.org/gene/9646:MS4A14 ^@ http://purl.uniprot.org/uniprot/G1L0N4 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9646:GCSH ^@ http://purl.uniprot.org/uniprot/D2H7J3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||Mitochondrion|||The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/9646:TGM6 ^@ http://purl.uniprot.org/uniprot/G1LY70 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9646:FRK ^@ http://purl.uniprot.org/uniprot/D2I0I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane http://togogenome.org/gene/9646:LPAR4 ^@ http://purl.uniprot.org/uniprot/D2I5D6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:HDHD3 ^@ http://purl.uniprot.org/uniprot/D2H2I8 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/9646:HS2ST1 ^@ http://purl.uniprot.org/uniprot/G1MCN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 3 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:FMR1 ^@ http://purl.uniprot.org/uniprot/A0A7N5K2Z0|||http://purl.uniprot.org/uniprot/A0A7N5K5W9|||http://purl.uniprot.org/uniprot/G1M932 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMR1 family.|||Cell membrane|||Cytoplasmic ribonucleoprotein granule|||Membrane|||Perikaryon|||Presynaptic cell membrane|||Stress granule|||Synapse|||Synaptic cell membrane|||axon|||centromere|||dendrite|||dendritic spine|||filopodium tip|||growth cone|||neuron projection|||nucleolus|||perinuclear region|||synaptosome http://togogenome.org/gene/9646:CNR1 ^@ http://purl.uniprot.org/uniprot/D2HSM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Mitochondrion outer membrane|||Presynapse|||Synapse|||axon http://togogenome.org/gene/9646:PLP1 ^@ http://purl.uniprot.org/uniprot/A0A7N5P3Z2|||http://purl.uniprot.org/uniprot/G1LWQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/9646:MTRF1L ^@ http://purl.uniprot.org/uniprot/G1L353 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Mitochondrion http://togogenome.org/gene/9646:RPAP1 ^@ http://purl.uniprot.org/uniprot/G1ME75 ^@ Similarity ^@ Belongs to the RPAP1 family. http://togogenome.org/gene/9646:FAM166C ^@ http://purl.uniprot.org/uniprot/G1L5V4 ^@ Similarity ^@ Belongs to the CIMIP2 family. http://togogenome.org/gene/9646:MSTO1 ^@ http://purl.uniprot.org/uniprot/D2HZK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the misato family.|||Mitochondrion outer membrane http://togogenome.org/gene/9646:LOC100481664 ^@ http://purl.uniprot.org/uniprot/G1M3M8 ^@ Similarity ^@ Belongs to the HPF1 family. http://togogenome.org/gene/9646:ARFGEF1 ^@ http://purl.uniprot.org/uniprot/D2H429 ^@ Subcellular Location Annotation ^@ Golgi apparatus|||perinuclear region http://togogenome.org/gene/9646:XRCC5 ^@ http://purl.uniprot.org/uniprot/G1L9U0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ku80 family.|||Nucleus http://togogenome.org/gene/9646:KCNJ10 ^@ http://purl.uniprot.org/uniprot/D2I3Z8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9646:IL1B ^@ http://purl.uniprot.org/uniprot/G1LW44 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-1 family.|||IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.|||Lysosome|||Monomer. Interacts with MEFV.|||Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.|||Secreted|||cytosol|||extracellular exosome http://togogenome.org/gene/9646:DNAAF1 ^@ http://purl.uniprot.org/uniprot/G1LIA6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNAAF1 family.|||Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli.|||cilium http://togogenome.org/gene/9646:CLK1 ^@ http://purl.uniprot.org/uniprot/A0A7N5K0W8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9646:CASK ^@ http://purl.uniprot.org/uniprot/G1LJM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Cell membrane http://togogenome.org/gene/9646:BCAS2 ^@ http://purl.uniprot.org/uniprot/D2I0G8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPF27 family.|||Nucleus http://togogenome.org/gene/9646:OXCT1 ^@ http://purl.uniprot.org/uniprot/G1MBJ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 3-oxoacid CoA-transferase family.|||Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.|||Mitochondrion http://togogenome.org/gene/9646:ELF2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JPE3|||http://purl.uniprot.org/uniprot/A0A7N5P6B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9646:GOLPH3L ^@ http://purl.uniprot.org/uniprot/A0A7N5JH38|||http://purl.uniprot.org/uniprot/A0A7N5KTC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLPH3/VPS74 family.|||Golgi stack membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9646:B9D2 ^@ http://purl.uniprot.org/uniprot/D2HMT6 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/9646:KXD1 ^@ http://purl.uniprot.org/uniprot/D2GV36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KXD1 family.|||Lysosome membrane http://togogenome.org/gene/9646:LOC100478188 ^@ http://purl.uniprot.org/uniprot/G1MKZ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:CKM ^@ http://purl.uniprot.org/uniprot/D2HPA6 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/9646:LOC100480781 ^@ http://purl.uniprot.org/uniprot/D2I082 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9646:CA3 ^@ http://purl.uniprot.org/uniprot/G1L714 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9646:SPOCK2 ^@ http://purl.uniprot.org/uniprot/A0A7N5P9C6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:MYO1B ^@ http://purl.uniprot.org/uniprot/A0A7N5JEU6|||http://purl.uniprot.org/uniprot/A0A7N5P711|||http://purl.uniprot.org/uniprot/D2H883 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9646:MELK ^@ http://purl.uniprot.org/uniprot/A0A7N5K5N7|||http://purl.uniprot.org/uniprot/A0A7N5KRB6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. http://togogenome.org/gene/9646:AURKA ^@ http://purl.uniprot.org/uniprot/G1LKV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.|||centrosome http://togogenome.org/gene/9646:EIF4A1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JJ60 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family. eIF4A subfamily.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9646:MPPED2 ^@ http://purl.uniprot.org/uniprot/D2HP03 ^@ Similarity ^@ Belongs to the UPF0046 family. http://togogenome.org/gene/9646:SLC6A14 ^@ http://purl.uniprot.org/uniprot/G1L4M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9646:NPY1R ^@ http://purl.uniprot.org/uniprot/D2HXK2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:EXT1 ^@ http://purl.uniprot.org/uniprot/G1L756 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:PNRC2 ^@ http://purl.uniprot.org/uniprot/D2GWD3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:TRPV1 ^@ http://purl.uniprot.org/uniprot/D2HZN8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:PRKACA ^@ http://purl.uniprot.org/uniprot/G1M3I9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/9646:GNG2 ^@ http://purl.uniprot.org/uniprot/D2HV45 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9646:ZKSCAN2 ^@ http://purl.uniprot.org/uniprot/D2I3U4 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9646:TIMM21 ^@ http://purl.uniprot.org/uniprot/D2HGK0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM21 family.|||Component of the TIM23 complex.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion membrane|||Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes. http://togogenome.org/gene/9646:RNF8 ^@ http://purl.uniprot.org/uniprot/G1MA53 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ According to a well-established model, RNF8 initiate H2A 'Lys-63'-linked ubiquitination leading to recruitment of RNF168 to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.|||Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger.|||Belongs to the CHFR family.|||Belongs to the RNF8 family.|||Cytoplasm|||E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains. Promotes non-homologous end joining (NHEJ) by promoting the 'Lys-48'-linked ubiquitination and degradation the of KU80/XRCC5. Following DNA damage, mediates the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF168, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Following DNA damage, mediates the ubiquitination and degradation of POLD4/p12, a subunit of DNA polymerase delta. In the absence of POLD4, DNA polymerase delta complex exhibits higher proofreading activity. In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation. Involved in the activation of ATM by promoting histone H2B ubiquitination, which indirectly triggers histone H4 'Lys-16' acetylation (H4K16ac), establishing a chromatin environment that promotes efficient activation of ATM kinase. Required in the testis, where it plays a role in the replacement of histones during spermatogenesis. At uncapped telomeres, promotes the joining of deprotected chromosome ends by inducing H2A ubiquitination and TP53BP1 recruitment, suggesting that it may enhance cancer development by aggravating telomere-induced genome instability in case of telomeric crisis. Promotes the assembly of RAD51 at DNA DSBs in the absence of BRCA1 and TP53BP1 Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. May be required for proper exit from mitosis after spindle checkpoint activation and may regulate cytokinesis. May play a role in the regulation of RXRA-mediated transcriptional activity. Not involved in RXRA ubiquitination by UBE2E2.|||Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N. Interacts with RXRA. Interacts (via FHA domain) with phosphorylated HERC2 (via C-terminus). Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm.|||Midbody|||Nucleus|||The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and phosphorylated HERC2.|||telomere http://togogenome.org/gene/9646:PNMT ^@ http://purl.uniprot.org/uniprot/G1LTY9 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. http://togogenome.org/gene/9646:FAM76B ^@ http://purl.uniprot.org/uniprot/D2HT51 ^@ Similarity ^@ Belongs to the FAM76 family. http://togogenome.org/gene/9646:RNPS1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JBP6|||http://purl.uniprot.org/uniprot/A0A7N5KDU8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the splicing factor SR family.|||Found in mRNA splicing-dependent exon junction complexes (EJC). Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively; the ASAP and PSAP complexes probably are formed mutually exclusive. Component of the active spliceosome. Associates with polysomes. Interacts with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1 and TRA2B/SFRS10.|||Nucleus speckle http://togogenome.org/gene/9646:LOC105240680 ^@ http://purl.uniprot.org/uniprot/A0A7N5JVK4|||http://purl.uniprot.org/uniprot/A0A7N5K2D1|||http://purl.uniprot.org/uniprot/A0A7N5K8N1|||http://purl.uniprot.org/uniprot/A0A7N5KKX0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:METTL15 ^@ http://purl.uniprot.org/uniprot/D2HEJ0 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. RsmH family. http://togogenome.org/gene/9646:RRN3 ^@ http://purl.uniprot.org/uniprot/A0A7N5KFY1 ^@ Similarity ^@ Belongs to the RRN3 family. http://togogenome.org/gene/9646:MYOG ^@ http://purl.uniprot.org/uniprot/D2HSE8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:FAM118A ^@ http://purl.uniprot.org/uniprot/G1LR18 ^@ Similarity ^@ Belongs to the FAM118 family. http://togogenome.org/gene/9646:SLC10A7 ^@ http://purl.uniprot.org/uniprot/A0A7N5P367 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Golgi apparatus membrane http://togogenome.org/gene/9646:MMACHC ^@ http://purl.uniprot.org/uniprot/D2HC38 ^@ Similarity ^@ Belongs to the MMACHC family. http://togogenome.org/gene/9646:SCP2 ^@ http://purl.uniprot.org/uniprot/G1LSE3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. Thiolase family.|||Cytoplasm|||Interacts with PEX5; the interaction is essential for peroxisomal import.|||Mitochondrion http://togogenome.org/gene/9646:STXBP1 ^@ http://purl.uniprot.org/uniprot/A0A7N5J998|||http://purl.uniprot.org/uniprot/G1MEC7 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9646:GJB6 ^@ http://purl.uniprot.org/uniprot/D2I264 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9646:APIP ^@ http://purl.uniprot.org/uniprot/G1LMZ8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aldolase class II family. Adducin subfamily.|||Belongs to the aldolase class II family. MtnB subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.|||Cytoplasm|||Homotetramer. Interacts with APAF1. May interact with CASP1. http://togogenome.org/gene/9646:HOXC10 ^@ http://purl.uniprot.org/uniprot/D2HM44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9646:ABRAXAS1 ^@ http://purl.uniprot.org/uniprot/D2GUE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM175 family. Abraxas subfamily.|||Nucleus http://togogenome.org/gene/9646:DCLRE1A ^@ http://purl.uniprot.org/uniprot/D2GX27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/9646:CALB1 ^@ http://purl.uniprot.org/uniprot/D2HLS9 ^@ Function|||Similarity ^@ Belongs to the calbindin family.|||Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. http://togogenome.org/gene/9646:UBE2C ^@ http://purl.uniprot.org/uniprot/G1M1K9 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9646:S100A8 ^@ http://purl.uniprot.org/uniprot/D2HJR9 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9646:SLC35B3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JNS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/9646:GET1 ^@ http://purl.uniprot.org/uniprot/D2HZR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WRB/GET1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:AASDHPPT ^@ http://purl.uniprot.org/uniprot/D2HJ98 ^@ Similarity ^@ Belongs to the P-Pant transferase superfamily. AcpS family. http://togogenome.org/gene/9646:BTG2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JZ37 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9646:ALDOC ^@ http://purl.uniprot.org/uniprot/D2GU33 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/9646:LOC100475108 ^@ http://purl.uniprot.org/uniprot/D2I5C9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:VPS33B ^@ http://purl.uniprot.org/uniprot/D2HCY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STXBP/unc-18/SEC1 family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||clathrin-coated vesicle http://togogenome.org/gene/9646:TM2D1 ^@ http://purl.uniprot.org/uniprot/G1LYZ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:IL20 ^@ http://purl.uniprot.org/uniprot/A0A7N5KH00 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/9646:DHRS3 ^@ http://purl.uniprot.org/uniprot/G1LJL1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9646:SLC30A1 ^@ http://purl.uniprot.org/uniprot/D2H655 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9646:ANK3 ^@ http://purl.uniprot.org/uniprot/A0A7N5KM44 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:USP26 ^@ http://purl.uniprot.org/uniprot/D2HAA6 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9646:FAM83G ^@ http://purl.uniprot.org/uniprot/D2HLB1 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9646:KEG54_p06 ^@ http://purl.uniprot.org/uniprot/A5JFK3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 3 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.|||Mitochondrion membrane http://togogenome.org/gene/9646:RER1 ^@ http://purl.uniprot.org/uniprot/D2HPP4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RER1 family.|||Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.|||Membrane http://togogenome.org/gene/9646:LOC100471579 ^@ http://purl.uniprot.org/uniprot/D2GZI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9646:BMP10 ^@ http://purl.uniprot.org/uniprot/D2I0Z0 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9646:ADH4 ^@ http://purl.uniprot.org/uniprot/A0A7N5P6U3 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/9646:COPS8 ^@ http://purl.uniprot.org/uniprot/D2I3M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN8 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:CPSF3 ^@ http://purl.uniprot.org/uniprot/G1LPK4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:B3GALT1 ^@ http://purl.uniprot.org/uniprot/D2HZZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:LOC100469936 ^@ http://purl.uniprot.org/uniprot/A0A7N5KS00 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:LOC100471322 ^@ http://purl.uniprot.org/uniprot/D2I837 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:B3GNT6 ^@ http://purl.uniprot.org/uniprot/G1MKU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:XK ^@ http://purl.uniprot.org/uniprot/D2GWX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9646:ATP6V1G1 ^@ http://purl.uniprot.org/uniprot/D2H2I0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9646:GJB7 ^@ http://purl.uniprot.org/uniprot/G1MPG3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9646:RUVBL2 ^@ http://purl.uniprot.org/uniprot/G1M7J2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RuvB family.|||Dynein axonemal particle|||Nucleus|||Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. http://togogenome.org/gene/9646:TNNT3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JHF1|||http://purl.uniprot.org/uniprot/A0A7N5P7H2 ^@ Function|||Similarity ^@ Belongs to the troponin T family.|||Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. http://togogenome.org/gene/9646:HSPA14 ^@ http://purl.uniprot.org/uniprot/G1LYF4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 70 family.|||Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.|||Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.|||cytosol http://togogenome.org/gene/9646:RPL26 ^@ http://purl.uniprot.org/uniprot/F2X269|||http://purl.uniprot.org/uniprot/Q2I0I6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||Component of the large ribosomal subunit. Interacts with DHX33.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||Cytoplasm|||Ufmylated by UFL1 in response to endoplasmic reticulum stress, promoting reticulophagy of endoplasmic reticulum sheets. http://togogenome.org/gene/9646:FAM13C ^@ http://purl.uniprot.org/uniprot/A0A7N5P1Q9 ^@ Similarity ^@ Belongs to the FAM13 family. http://togogenome.org/gene/9646:ASF1B ^@ http://purl.uniprot.org/uniprot/D2HFZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/9646:EMC4 ^@ http://purl.uniprot.org/uniprot/D2HRS4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC4 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:PSMD4 ^@ http://purl.uniprot.org/uniprot/G1L1M2 ^@ Similarity ^@ Belongs to the proteasome subunit S5A family. http://togogenome.org/gene/9646:MYOF ^@ http://purl.uniprot.org/uniprot/A0A7N5JXU4|||http://purl.uniprot.org/uniprot/G1M5W2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ferlin family.|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/9646:CDC42 ^@ http://purl.uniprot.org/uniprot/D2HCB2|||http://purl.uniprot.org/uniprot/G1M7S7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.|||Cell membrane|||Membrane|||Midbody|||Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. http://togogenome.org/gene/9646:NDUFS1 ^@ http://purl.uniprot.org/uniprot/G1L8K6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I 75 kDa subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:LOC100469532 ^@ http://purl.uniprot.org/uniprot/G1MJM3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:BANP ^@ http://purl.uniprot.org/uniprot/A0A7N5KGD6 ^@ Similarity ^@ Belongs to the BANP/SMAR1 family. http://togogenome.org/gene/9646:LOC100482800 ^@ http://purl.uniprot.org/uniprot/D2I4T6 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9646:POU4F2 ^@ http://purl.uniprot.org/uniprot/D2H3Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/9646:VSX2 ^@ http://purl.uniprot.org/uniprot/D2GZW4|||http://purl.uniprot.org/uniprot/G1MIX3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:SKAP2 ^@ http://purl.uniprot.org/uniprot/G1LH71 ^@ Similarity ^@ Belongs to the SKAP family. http://togogenome.org/gene/9646:ARL2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JY22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||centrosome http://togogenome.org/gene/9646:GPR18 ^@ http://purl.uniprot.org/uniprot/G1MP70 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:CALR ^@ http://purl.uniprot.org/uniprot/D2HG17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calreticulin family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9646:LOC100483550 ^@ http://purl.uniprot.org/uniprot/D2I3T4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:SLC22A4 ^@ http://purl.uniprot.org/uniprot/A0A7N5KGR7|||http://purl.uniprot.org/uniprot/G1MH36 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Basal cell membrane|||Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.|||Interacts with PDZK1. http://togogenome.org/gene/9646:PIM2 ^@ http://purl.uniprot.org/uniprot/D2H7M9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. http://togogenome.org/gene/9646:TMTC2 ^@ http://purl.uniprot.org/uniprot/G1MEQ3|||http://purl.uniprot.org/uniprot/G1MEQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/9646:LOC100470176 ^@ http://purl.uniprot.org/uniprot/G1M528 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase IV family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9646:PURG ^@ http://purl.uniprot.org/uniprot/G1MM22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PUR DNA-binding protein family.|||Nucleus http://togogenome.org/gene/9646:HDAC2 ^@ http://purl.uniprot.org/uniprot/G1M3K7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.|||Nucleus http://togogenome.org/gene/9646:CUTA ^@ http://purl.uniprot.org/uniprot/G1L3M5|||http://purl.uniprot.org/uniprot/G1L3N1 ^@ Similarity|||Subunit ^@ Belongs to the CutA family.|||Homotrimer. http://togogenome.org/gene/9646:SCD ^@ http://purl.uniprot.org/uniprot/G1LJK5 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Membrane|||The histidine box domains are involved in binding the catalytic metal ions. http://togogenome.org/gene/9646:UNK ^@ http://purl.uniprot.org/uniprot/A0A7N5JPV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unkempt family.|||Cytoplasm http://togogenome.org/gene/9646:CHGB ^@ http://purl.uniprot.org/uniprot/G1LUG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromogranin/secretogranin protein family.|||Secreted http://togogenome.org/gene/9646:ATXN1L ^@ http://purl.uniprot.org/uniprot/D2HFW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATXN1 family.|||Nucleus http://togogenome.org/gene/9646:SLC7A14 ^@ http://purl.uniprot.org/uniprot/D2HFL8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:CDC42EP3 ^@ http://purl.uniprot.org/uniprot/D2H091 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/9646:METTL8 ^@ http://purl.uniprot.org/uniprot/G1LPX4 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/9646:CCR7 ^@ http://purl.uniprot.org/uniprot/G1LNB1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:LOC100471279 ^@ http://purl.uniprot.org/uniprot/D2HK51 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:C16H11orf68 ^@ http://purl.uniprot.org/uniprot/D2H4N7 ^@ Similarity ^@ Belongs to the UPF0696 family. http://togogenome.org/gene/9646:SLC30A3 ^@ http://purl.uniprot.org/uniprot/G1L4C4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9646:MYH10 ^@ http://purl.uniprot.org/uniprot/G1L6J5 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9646:TMED6 ^@ http://purl.uniprot.org/uniprot/D2HLI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:PDGFRL ^@ http://purl.uniprot.org/uniprot/G1M4Z5 ^@ Subunit ^@ Forms a complex composed of PDGFRL, TNK2 and GRB2. http://togogenome.org/gene/9646:LOC100464709 ^@ http://purl.uniprot.org/uniprot/D2I6R3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9646:CACNG3 ^@ http://purl.uniprot.org/uniprot/D2HV93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane http://togogenome.org/gene/9646:PGLYRP2 ^@ http://purl.uniprot.org/uniprot/A0A7N5P7E0 ^@ Similarity ^@ Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. http://togogenome.org/gene/9646:CLSTN3 ^@ http://purl.uniprot.org/uniprot/G1M4J3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calsyntenin family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Postsynaptic cell membrane http://togogenome.org/gene/9646:ARRDC2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JPM3 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9646:DIPK2A ^@ http://purl.uniprot.org/uniprot/D2H596 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Secreted http://togogenome.org/gene/9646:PTP4A3 ^@ http://purl.uniprot.org/uniprot/D2HHH7 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9646:GUCY1B1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JBE8|||http://purl.uniprot.org/uniprot/G1MAB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Cytoplasm http://togogenome.org/gene/9646:PHKG1 ^@ http://purl.uniprot.org/uniprot/D2HTC4 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily.|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin. http://togogenome.org/gene/9646:IGF2BP3 ^@ http://purl.uniprot.org/uniprot/G1L9V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM IMP/VICKZ family.|||P-body|||Stress granule http://togogenome.org/gene/9646:HR ^@ http://purl.uniprot.org/uniprot/D2H051 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the JHDM2 histone demethylase family.|||Binds 1 Fe(2+) ion per subunit.|||Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.|||Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.|||Nucleus|||The JmjC domain and the C6-type zinc-finger are required for the demethylation activity. http://togogenome.org/gene/9646:LGI1 ^@ http://purl.uniprot.org/uniprot/G1M530 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9646:RP2 ^@ http://purl.uniprot.org/uniprot/D2HXE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBCC family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:DEF8 ^@ http://purl.uniprot.org/uniprot/G1L3M3 ^@ Similarity ^@ Belongs to the DEF8 family. http://togogenome.org/gene/9646:AASS ^@ http://purl.uniprot.org/uniprot/D2HAX9 ^@ Similarity ^@ In the C-terminal section; belongs to the saccharopine dehydrogenase family.|||In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/9646:GATAD2B ^@ http://purl.uniprot.org/uniprot/D2HJQ3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:PLPPR4 ^@ http://purl.uniprot.org/uniprot/D2HFF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9646:LOC100477312 ^@ http://purl.uniprot.org/uniprot/D2H9N9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9646:GAD2 ^@ http://purl.uniprot.org/uniprot/D2HYX7 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9646:VPS13A ^@ http://purl.uniprot.org/uniprot/G1LFG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS13 family.|||Lipid droplet http://togogenome.org/gene/9646:CPSF7 ^@ http://purl.uniprot.org/uniprot/G1MDV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM CPSF6/7 family.|||Nucleus http://togogenome.org/gene/9646:TMEM233 ^@ http://purl.uniprot.org/uniprot/G1MC62 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9646:SLC25A13 ^@ http://purl.uniprot.org/uniprot/G1LV59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9646:ADRA1A ^@ http://purl.uniprot.org/uniprot/G1L034 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Membrane|||Nucleus membrane|||caveola http://togogenome.org/gene/9646:VDAC2 ^@ http://purl.uniprot.org/uniprot/G1L4H5 ^@ Similarity ^@ Belongs to the eukaryotic mitochondrial porin family. http://togogenome.org/gene/9646:BDKRB2 ^@ http://purl.uniprot.org/uniprot/G1LAZ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.|||Membrane|||Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9646:HK3 ^@ http://purl.uniprot.org/uniprot/G1LLC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hexokinase family.|||Membrane|||Mitochondrion outer membrane|||cytosol http://togogenome.org/gene/9646:IGBP1 ^@ http://purl.uniprot.org/uniprot/A0A7N5P1T2 ^@ Similarity ^@ Belongs to the IGBP1/TAP42 family. http://togogenome.org/gene/9646:POLD3 ^@ http://purl.uniprot.org/uniprot/G1MFJ5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:MEOX1 ^@ http://purl.uniprot.org/uniprot/D2HCT9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:RPS27A ^@ http://purl.uniprot.org/uniprot/A0A7N5KHN5 ^@ Similarity ^@ In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.|||In the N-terminal section; belongs to the ubiquitin family. http://togogenome.org/gene/9646:RAB27A ^@ http://purl.uniprot.org/uniprot/D2HKW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/9646:CLRN3 ^@ http://purl.uniprot.org/uniprot/D2HHV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/9646:ACTN4 ^@ http://purl.uniprot.org/uniprot/D2HTG8 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/9646:GCG ^@ http://purl.uniprot.org/uniprot/D2HQW4 ^@ Similarity ^@ Belongs to the glucagon family. http://togogenome.org/gene/9646:ATP13A3 ^@ http://purl.uniprot.org/uniprot/A0A7N5J9H6|||http://purl.uniprot.org/uniprot/A0A7N5KEX8|||http://purl.uniprot.org/uniprot/G1LRV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.|||Membrane http://togogenome.org/gene/9646:MAN2A1 ^@ http://purl.uniprot.org/uniprot/D2HDB2 ^@ Cofactor|||Similarity ^@ Belongs to the glycosyl hydrolase 38 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9646:NPR2 ^@ http://purl.uniprot.org/uniprot/D2HAL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane http://togogenome.org/gene/9646:ST6GAL1 ^@ http://purl.uniprot.org/uniprot/D2H070 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9646:LOC100499574 ^@ http://purl.uniprot.org/uniprot/Q5XLE5 ^@ Similarity|||Subunit|||Tissue Specificity ^@ Belongs to the globin family.|||Heterotetramer of two delta chains and two alpha chains.|||Red blood cells. http://togogenome.org/gene/9646:TNFSF10 ^@ http://purl.uniprot.org/uniprot/G1L2D8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Homotrimer.|||Membrane|||Secreted http://togogenome.org/gene/9646:ACAD9 ^@ http://purl.uniprot.org/uniprot/G1MA98 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9646:RAB9A ^@ http://purl.uniprot.org/uniprot/D2HXD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||phagosome membrane http://togogenome.org/gene/9646:SPO11 ^@ http://purl.uniprot.org/uniprot/D2H1Z1|||http://purl.uniprot.org/uniprot/G1M2C7 ^@ Similarity ^@ Belongs to the TOP6A family. http://togogenome.org/gene/9646:SBK2 ^@ http://purl.uniprot.org/uniprot/A0A7N5K9T0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9646:SESN2 ^@ http://purl.uniprot.org/uniprot/G1LXT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/9646:AK2 ^@ http://purl.uniprot.org/uniprot/A0A7N5J995|||http://purl.uniprot.org/uniprot/A0A7N5JJ22|||http://purl.uniprot.org/uniprot/D2HI44 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Belongs to the adenylate kinase family. AK2 subfamily.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Mitochondrion intermembrane space|||Monomer. http://togogenome.org/gene/9646:LOC100470296 ^@ http://purl.uniprot.org/uniprot/D2I8E6 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:IL15 ^@ http://purl.uniprot.org/uniprot/A0A7N5JBC7|||http://purl.uniprot.org/uniprot/B0ZE70 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems. Stimulates the proliferation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines. In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection. Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits. Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5 (By similarity). In mast cells, induces the rapid tyrosine phosphorylation of STAT6 and thereby controls mast cell survival and release of cytokines such as IL4 (By similarity).|||Secreted http://togogenome.org/gene/9646:SLC25A31 ^@ http://purl.uniprot.org/uniprot/G1L752 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/9646:SUDS3 ^@ http://purl.uniprot.org/uniprot/G1MCC1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:PLA2G15 ^@ http://purl.uniprot.org/uniprot/G1LN15 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9646:SRFBP1 ^@ http://purl.uniprot.org/uniprot/G1MI85 ^@ Function|||Subunit ^@ Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4.|||May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells. http://togogenome.org/gene/9646:MVP ^@ http://purl.uniprot.org/uniprot/D2HX35 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. http://togogenome.org/gene/9646:MINDY1 ^@ http://purl.uniprot.org/uniprot/G1L2N5 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM63 subfamily.|||Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover. http://togogenome.org/gene/9646:MRM1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KBC3 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. http://togogenome.org/gene/9646:RAG1 ^@ http://purl.uniprot.org/uniprot/D2HV49 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RAG1 family.|||Binds 1 divalent metal cation per subunit. Mg(2+) or Mn(2+).|||Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends.|||Homodimer.|||Nucleus|||The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp. http://togogenome.org/gene/9646:CPNE4 ^@ http://purl.uniprot.org/uniprot/A0A7N5K7D1 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9646:SMIM15 ^@ http://purl.uniprot.org/uniprot/D2H3U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM15 family.|||Membrane http://togogenome.org/gene/9646:NUDCD1 ^@ http://purl.uniprot.org/uniprot/D2HA60 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9646:SLC39A2 ^@ http://purl.uniprot.org/uniprot/D2HYC9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:CLPTM1L ^@ http://purl.uniprot.org/uniprot/G1LVX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLPTM1 family.|||Membrane http://togogenome.org/gene/9646:RIF1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JH00|||http://purl.uniprot.org/uniprot/A0A7N5KAA3|||http://purl.uniprot.org/uniprot/G1LPF7 ^@ Subcellular Location Annotation ^@ Nucleus|||telomere http://togogenome.org/gene/9646:CEP20 ^@ http://purl.uniprot.org/uniprot/G1LRS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP43 family.|||centriole|||cilium basal body http://togogenome.org/gene/9646:KIAA1191 ^@ http://purl.uniprot.org/uniprot/G1LK87 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P33MONOX family.|||Cytoplasm|||Interacts with NELFB, NOL12 and PRNP.|||Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth. http://togogenome.org/gene/9646:LOC100473402 ^@ http://purl.uniprot.org/uniprot/G1MMN2 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:PCYT1B ^@ http://purl.uniprot.org/uniprot/G1M8I0 ^@ Function|||Similarity ^@ Belongs to the cytidylyltransferase family.|||Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. http://togogenome.org/gene/9646:PPIH ^@ http://purl.uniprot.org/uniprot/G1L0Z5 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9646:CAND1 ^@ http://purl.uniprot.org/uniprot/G1LQ96 ^@ Similarity ^@ Belongs to the CAND family. http://togogenome.org/gene/9646:TIMM10B ^@ http://purl.uniprot.org/uniprot/G1MD05 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9646:EMSY ^@ http://purl.uniprot.org/uniprot/A0A7N5JKD3|||http://purl.uniprot.org/uniprot/A0A7N5JWY3|||http://purl.uniprot.org/uniprot/A0A7N5KBQ2|||http://purl.uniprot.org/uniprot/A0A7N5P9I8|||http://purl.uniprot.org/uniprot/G1MEU6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:PANX1 ^@ http://purl.uniprot.org/uniprot/G1LZM9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Membrane|||S-nitrosylation inhibits channel currents and ATP release.|||Structural component of the gap junctions and the hemichannels.|||gap junction http://togogenome.org/gene/9646:EIF6 ^@ http://purl.uniprot.org/uniprot/G1LT74 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-6 family.|||Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.|||Cytoplasm|||Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).|||Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.|||nucleolus http://togogenome.org/gene/9646:RFPL4B ^@ http://purl.uniprot.org/uniprot/G1MLK1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:GAST ^@ http://purl.uniprot.org/uniprot/G1LG97 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gastrin/cholecystokinin family.|||Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.|||Secreted http://togogenome.org/gene/9646:BCLAF3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JM63 ^@ Similarity ^@ Belongs to the BCLAF1/THRAP3 family. http://togogenome.org/gene/9646:TMEM218 ^@ http://purl.uniprot.org/uniprot/G1L256 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM218 family.|||May be involved in ciliary biogenesis or function.|||Membrane|||cilium http://togogenome.org/gene/9646:TNFAIP3 ^@ http://purl.uniprot.org/uniprot/D2H0U3 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9646:NAP1L5 ^@ http://purl.uniprot.org/uniprot/G1MP62 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9646:LOC100470709 ^@ http://purl.uniprot.org/uniprot/G1ML39 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:CEP44 ^@ http://purl.uniprot.org/uniprot/G1M6H4 ^@ Subcellular Location Annotation ^@ Midbody|||centriole|||spindle pole http://togogenome.org/gene/9646:DKC1 ^@ http://purl.uniprot.org/uniprot/G1L7S2 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/9646:PNOC ^@ http://purl.uniprot.org/uniprot/G1L9C2 ^@ Similarity ^@ Belongs to the opioid neuropeptide precursor family. http://togogenome.org/gene/9646:FAP ^@ http://purl.uniprot.org/uniprot/G1LGG1 ^@ Subcellular Location Annotation ^@ Cell membrane|||invadopodium membrane|||lamellipodium membrane http://togogenome.org/gene/9646:CASP3 ^@ http://purl.uniprot.org/uniprot/G1LPC3 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9646:LOC100473053 ^@ http://purl.uniprot.org/uniprot/D2HW31 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:DHDH ^@ http://purl.uniprot.org/uniprot/G1M7U0 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. http://togogenome.org/gene/9646:SLC27A6 ^@ http://purl.uniprot.org/uniprot/D2H7D9 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9646:NPY ^@ http://purl.uniprot.org/uniprot/G1LHW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Secreted http://togogenome.org/gene/9646:SLC30A6 ^@ http://purl.uniprot.org/uniprot/A0A7N5JQE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9646:KHDRBS1 ^@ http://purl.uniprot.org/uniprot/D2HI64 ^@ Similarity ^@ Belongs to the KHDRBS family. http://togogenome.org/gene/9646:DDC ^@ http://purl.uniprot.org/uniprot/A0A7N5KAB3 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9646:DOK1 ^@ http://purl.uniprot.org/uniprot/D2HH52 ^@ Similarity ^@ Belongs to the DOK family. Type A subfamily. http://togogenome.org/gene/9646:UBE2L6 ^@ http://purl.uniprot.org/uniprot/G1M7H7 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9646:CASP2 ^@ http://purl.uniprot.org/uniprot/A0A7N5KK81|||http://purl.uniprot.org/uniprot/G1LJ60 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9646:INTS2 ^@ http://purl.uniprot.org/uniprot/G1LQ98 ^@ Similarity ^@ Belongs to the Integrator subunit 2 family. http://togogenome.org/gene/9646:MRPL27 ^@ http://purl.uniprot.org/uniprot/G1LZH3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/9646:PRDM14 ^@ http://purl.uniprot.org/uniprot/D2H9L4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:PRR15L ^@ http://purl.uniprot.org/uniprot/A0A7N5KH38 ^@ Similarity ^@ Belongs to the PRR15 family. http://togogenome.org/gene/9646:SAR1A ^@ http://purl.uniprot.org/uniprot/D2GXH1 ^@ Similarity ^@ Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/9646:CAMSAP2 ^@ http://purl.uniprot.org/uniprot/A0A7N5KLE7|||http://purl.uniprot.org/uniprot/D2GZP3 ^@ Domain|||Similarity ^@ Belongs to the CAMSAP1 family.|||The CKK domain binds microtubules. http://togogenome.org/gene/9646:SPACA4 ^@ http://purl.uniprot.org/uniprot/G1MNE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPACA4/bouncer family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:HTR1E ^@ http://purl.uniprot.org/uniprot/D2HQH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:XPO7 ^@ http://purl.uniprot.org/uniprot/A0A7N5JW40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:ARHGDIB ^@ http://purl.uniprot.org/uniprot/D2HZU9 ^@ Similarity ^@ Belongs to the Rho GDI family. http://togogenome.org/gene/9646:CCT4 ^@ http://purl.uniprot.org/uniprot/G1LA28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9646:MEGF10 ^@ http://purl.uniprot.org/uniprot/A0A7N5JZY1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:GANC ^@ http://purl.uniprot.org/uniprot/G1MCA4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/9646:SERPINA12 ^@ http://purl.uniprot.org/uniprot/D2HEM6 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9646:RBM8A ^@ http://purl.uniprot.org/uniprot/G1MGY3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RBM8A family.|||Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.|||Cytoplasm|||Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.|||Nucleus|||Nucleus speckle http://togogenome.org/gene/9646:UFC1 ^@ http://purl.uniprot.org/uniprot/D2I0T5 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily. http://togogenome.org/gene/9646:DR1 ^@ http://purl.uniprot.org/uniprot/G1LT63 ^@ Similarity ^@ Belongs to the NC2 beta/DR1 family. http://togogenome.org/gene/9646:LOC100475278 ^@ http://purl.uniprot.org/uniprot/D2I466 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:AASDH ^@ http://purl.uniprot.org/uniprot/A0A7N5JGP0 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9646:IL17RC ^@ http://purl.uniprot.org/uniprot/G1MCL8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:ARID3B ^@ http://purl.uniprot.org/uniprot/D2HKY8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Heterodimer with ARID3A. Interacts with unphosphorylated RB1.|||Nucleus|||Transcription factor. http://togogenome.org/gene/9646:FZD4 ^@ http://purl.uniprot.org/uniprot/D2HRQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:ESS2 ^@ http://purl.uniprot.org/uniprot/D2HEX3|||http://purl.uniprot.org/uniprot/G1LXQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESS2 family.|||Nucleus http://togogenome.org/gene/9646:TMEM126B ^@ http://purl.uniprot.org/uniprot/G1LQ19 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:UBALD1 ^@ http://purl.uniprot.org/uniprot/D2HQ77 ^@ Similarity ^@ Belongs to the UBALD family. http://togogenome.org/gene/9646:SLF2 ^@ http://purl.uniprot.org/uniprot/G1MGQ5 ^@ Similarity ^@ Belongs to the FAM178 family. http://togogenome.org/gene/9646:TEKT5 ^@ http://purl.uniprot.org/uniprot/D2HK12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/9646:CHAC2 ^@ http://purl.uniprot.org/uniprot/G1LD45 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.|||Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. http://togogenome.org/gene/9646:CDC34 ^@ http://purl.uniprot.org/uniprot/D2HMB9 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9646:ACER1 ^@ http://purl.uniprot.org/uniprot/D2HY69 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Membrane http://togogenome.org/gene/9646:FAM216A ^@ http://purl.uniprot.org/uniprot/G1M5S4 ^@ Similarity ^@ Belongs to the FAM216 family. http://togogenome.org/gene/9646:GSTM3 ^@ http://purl.uniprot.org/uniprot/G1LEK1 ^@ Similarity ^@ Belongs to the GST superfamily. Mu family. http://togogenome.org/gene/9646:ANKH ^@ http://purl.uniprot.org/uniprot/G1LT81 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANKH family.|||Membrane|||Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter. http://togogenome.org/gene/9646:GOLT1B ^@ http://purl.uniprot.org/uniprot/A0A7N5P6M5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||May be involved in fusion of ER-derived transport vesicles with the Golgi complex.|||Membrane http://togogenome.org/gene/9646:BLCAP ^@ http://purl.uniprot.org/uniprot/D2H116 ^@ Similarity ^@ Belongs to the BLCAP family. http://togogenome.org/gene/9646:RDH12 ^@ http://purl.uniprot.org/uniprot/G1LN50 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9646:PSENEN ^@ http://purl.uniprot.org/uniprot/D2HFS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PEN-2 family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9646:LOC100482919 ^@ http://purl.uniprot.org/uniprot/D2H5T7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm http://togogenome.org/gene/9646:SCARA5 ^@ http://purl.uniprot.org/uniprot/D2GZ57|||http://purl.uniprot.org/uniprot/G1KZU1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCARA5 family.|||Cell membrane|||Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).|||Homotrimer.|||Membrane http://togogenome.org/gene/9646:LIG3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JL15|||http://purl.uniprot.org/uniprot/G1M7L6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent DNA ligase family.|||Nucleus http://togogenome.org/gene/9646:SCML4 ^@ http://purl.uniprot.org/uniprot/D2H6J0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCM family.|||Nucleus http://togogenome.org/gene/9646:FOXI1 ^@ http://purl.uniprot.org/uniprot/D2I7N9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:TFAP2B ^@ http://purl.uniprot.org/uniprot/D2H1N5 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/9646:GPR180 ^@ http://purl.uniprot.org/uniprot/D2H9Z3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:H1-5 ^@ http://purl.uniprot.org/uniprot/D2HWI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9646:GPR33 ^@ http://purl.uniprot.org/uniprot/G1MN65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chemokine-like receptor (CMKLR) family.|||Membrane http://togogenome.org/gene/9646:LOC100479689 ^@ http://purl.uniprot.org/uniprot/D2HTD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 6A family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9646:TRIM45 ^@ http://purl.uniprot.org/uniprot/D2HMJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm http://togogenome.org/gene/9646:LOC100475247 ^@ http://purl.uniprot.org/uniprot/G1L8J5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. ICAM family.|||Membrane http://togogenome.org/gene/9646:LOC100464962 ^@ http://purl.uniprot.org/uniprot/D2I731 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:DUSP16 ^@ http://purl.uniprot.org/uniprot/D2H873 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/9646:ANXA9 ^@ http://purl.uniprot.org/uniprot/D2HBT4 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9646:B4GALT2 ^@ http://purl.uniprot.org/uniprot/D2HSQ0|||http://purl.uniprot.org/uniprot/G1L2L7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9646:CDC5L ^@ http://purl.uniprot.org/uniprot/G1LZ29 ^@ Similarity ^@ Belongs to the CEF1 family. http://togogenome.org/gene/9646:ETV7 ^@ http://purl.uniprot.org/uniprot/A0A7N5KGB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9646:HK2 ^@ http://purl.uniprot.org/uniprot/G1MFD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hexokinase family.|||Membrane|||Mitochondrion outer membrane|||cytosol http://togogenome.org/gene/9646:LOC100471524 ^@ http://purl.uniprot.org/uniprot/D2HK52 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:RANBP10 ^@ http://purl.uniprot.org/uniprot/D2H9F5 ^@ Similarity ^@ Belongs to the RANBP9/10 family. http://togogenome.org/gene/9646:CAB39L ^@ http://purl.uniprot.org/uniprot/D2HB73 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mo25 family.|||Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.|||Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. http://togogenome.org/gene/9646:REXO2 ^@ http://purl.uniprot.org/uniprot/D2HVG0 ^@ Similarity ^@ Belongs to the oligoribonuclease family. http://togogenome.org/gene/9646:LRFN3 ^@ http://purl.uniprot.org/uniprot/D2HFT7 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LRFN family.|||Can form heteromeric complexes with LRFN1, LRFN2, LRFN4 and LRFN5. Able to form homomeric complexes across cell junctions, between adjacent cells. Does not interact with DLG4 (By similarity).|||Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons (By similarity).|||Cell membrane|||Lacks a cytoplasmic PDZ-binding domain, which has been implicated in function of related Lrfn proteins.|||N-glycosylated.|||Postsynaptic cell membrane|||Presynaptic cell membrane|||Synapse|||axon|||dendrite http://togogenome.org/gene/9646:ATP5F1D ^@ http://purl.uniprot.org/uniprot/G1L969 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase epsilon chain family.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:SCRN3 ^@ http://purl.uniprot.org/uniprot/G1M0M7 ^@ Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily. http://togogenome.org/gene/9646:MFAP3 ^@ http://purl.uniprot.org/uniprot/D2I7E5 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9646:ODR4 ^@ http://purl.uniprot.org/uniprot/G1MAJ4 ^@ Function|||Similarity ^@ Belongs to the ODR-4 family.|||May play a role in the trafficking of a subset of G-protein coupled receptors. http://togogenome.org/gene/9646:IHH ^@ http://purl.uniprot.org/uniprot/D2GXC0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the hedgehog family.|||Cell membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane|||Multimer. http://togogenome.org/gene/9646:FSCN3 ^@ http://purl.uniprot.org/uniprot/G1LDA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fascin family.|||cytoskeleton http://togogenome.org/gene/9646:VAMP1 ^@ http://purl.uniprot.org/uniprot/G1M7A0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9646:FOXP1 ^@ http://purl.uniprot.org/uniprot/G1M995 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:TMEM265 ^@ http://purl.uniprot.org/uniprot/A0A7N5J8U8 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9646:TMOD4 ^@ http://purl.uniprot.org/uniprot/D2HBS4 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9646:PIR ^@ http://purl.uniprot.org/uniprot/D2I1C1 ^@ Similarity ^@ Belongs to the pirin family. http://togogenome.org/gene/9646:DDX3X ^@ http://purl.uniprot.org/uniprot/A0A7N5K269|||http://purl.uniprot.org/uniprot/G1LJW1 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9646:ZDHHC23 ^@ http://purl.uniprot.org/uniprot/A0A7N5KB15|||http://purl.uniprot.org/uniprot/G1LFD6 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9646:CCS ^@ http://purl.uniprot.org/uniprot/G1LWR7 ^@ Similarity ^@ In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family. http://togogenome.org/gene/9646:APPL2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JXB2 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Endosome membrane|||Membrane|||Nucleus|||phagosome|||ruffle http://togogenome.org/gene/9646:ADRB2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JT44 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.|||Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.|||Cell membrane|||Early endosome|||Golgi apparatus|||Membrane http://togogenome.org/gene/9646:TOP2A ^@ http://purl.uniprot.org/uniprot/A0A7N5PAN7|||http://purl.uniprot.org/uniprot/G1LN78 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II topoisomerase family.|||Homodimer.|||Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9646:ATM ^@ http://purl.uniprot.org/uniprot/G1MEC3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PI3/PI4-kinase family. ATM subfamily.|||Cytoplasmic vesicle|||Nucleus|||Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9, UBQLN4 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent histone mRNA degradation. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response. Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks. http://togogenome.org/gene/9646:LOC100476661 ^@ http://purl.uniprot.org/uniprot/D2HRD0 ^@ Similarity ^@ Belongs to the GST superfamily. Theta family. http://togogenome.org/gene/9646:ACKR4 ^@ http://purl.uniprot.org/uniprot/G1MPB3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:ADAM28 ^@ http://purl.uniprot.org/uniprot/A0A7N5JMU1|||http://purl.uniprot.org/uniprot/A0A7N5P4W6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:NDUFA11 ^@ http://purl.uniprot.org/uniprot/G1LMS5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA11 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:RPS6KA2 ^@ http://purl.uniprot.org/uniprot/A0A7N5KIY2|||http://purl.uniprot.org/uniprot/A0A7N5KL31|||http://purl.uniprot.org/uniprot/A0A7N5KP03 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9646:CD40 ^@ http://purl.uniprot.org/uniprot/G1M2N0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:RBM3 ^@ http://purl.uniprot.org/uniprot/G1M1W2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:LOC117794981 ^@ http://purl.uniprot.org/uniprot/D2CMN8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9646:AMD1 ^@ http://purl.uniprot.org/uniprot/D2HXL4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic AdoMetDC family.|||Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.|||Heterotetramer of two alpha and two beta chains. http://togogenome.org/gene/9646:FOXJ1 ^@ http://purl.uniprot.org/uniprot/D2HD62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FOXJ1 family.|||Nucleus http://togogenome.org/gene/9646:LYNX1 ^@ http://purl.uniprot.org/uniprot/A0A7N5P869 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9646:FAM131B ^@ http://purl.uniprot.org/uniprot/G1LJE5 ^@ Similarity ^@ Belongs to the FAM131 family. http://togogenome.org/gene/9646:OGDH ^@ http://purl.uniprot.org/uniprot/A0A7N5KK68|||http://purl.uniprot.org/uniprot/D2HNP1 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/9646:LAMTOR1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JC97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR1 family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/9646:GTF2H1 ^@ http://purl.uniprot.org/uniprot/D2HU87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB1 family.|||Nucleus http://togogenome.org/gene/9646:LOC100480278 ^@ http://purl.uniprot.org/uniprot/G1MCR5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG10 glucosyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:ARHGEF6 ^@ http://purl.uniprot.org/uniprot/D2HD92 ^@ Subcellular Location Annotation ^@ lamellipodium http://togogenome.org/gene/9646:SLC26A2 ^@ http://purl.uniprot.org/uniprot/D2H8M6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane|||Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development. Mediates electroneutral anion exchange of sulfate ions for oxalate ions, sulfate and oxalate ions for chloride and/or hydroxyl ions and chloride ions for bromide, iodide and nitrate ions. The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange. Essential for chondrocyte proliferation, differentiation and cell size expansion. http://togogenome.org/gene/9646:NNT ^@ http://purl.uniprot.org/uniprot/G1LBH1 ^@ Similarity ^@ In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/9646:GUSB ^@ http://purl.uniprot.org/uniprot/A0A7N5JBQ5 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 2 family.|||Homotetramer.|||Inhibited by L-aspartic acid.|||Lysosome|||Plays an important role in the degradation of dermatan and keratan sulfates. http://togogenome.org/gene/9646:P2RY1 ^@ http://purl.uniprot.org/uniprot/D2H406 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:LOC100476755 ^@ http://purl.uniprot.org/uniprot/G1L1E1 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/9646:LOC100470800 ^@ http://purl.uniprot.org/uniprot/G1MJY1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:CD93 ^@ http://purl.uniprot.org/uniprot/G1LTF0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:SETD7 ^@ http://purl.uniprot.org/uniprot/G1LWT3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.|||Chromosome|||Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.|||Nucleus http://togogenome.org/gene/9646:B3GAT1 ^@ http://purl.uniprot.org/uniprot/D2H5A6|||http://purl.uniprot.org/uniprot/G1LLP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:SIAH1 ^@ http://purl.uniprot.org/uniprot/G1LUQ5 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/9646:DDX4 ^@ http://purl.uniprot.org/uniprot/A0A7N5JG35|||http://purl.uniprot.org/uniprot/A0A7N5JKV9|||http://purl.uniprot.org/uniprot/A0A7N5PAS5 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9646:CDK5RAP3 ^@ http://purl.uniprot.org/uniprot/G1LDX7 ^@ Similarity ^@ Belongs to the CDK5RAP3 family. http://togogenome.org/gene/9646:GNG5 ^@ http://purl.uniprot.org/uniprot/D2I7X9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9646:LOC105242197 ^@ http://purl.uniprot.org/uniprot/G1MNE6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:CNKSR3 ^@ http://purl.uniprot.org/uniprot/G1LLZ9 ^@ Similarity ^@ Belongs to the CNKSR family. http://togogenome.org/gene/9646:LDB2 ^@ http://purl.uniprot.org/uniprot/G1L4J8 ^@ Similarity ^@ Belongs to the LDB family. http://togogenome.org/gene/9646:FAM214B ^@ http://purl.uniprot.org/uniprot/D2I1Z8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATOS family.|||Nucleus http://togogenome.org/gene/9646:SEC62 ^@ http://purl.uniprot.org/uniprot/G1LD82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC62 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:AP1M2 ^@ http://purl.uniprot.org/uniprot/G1LXZ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Golgi apparatus|||Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9646:ERC1 ^@ http://purl.uniprot.org/uniprot/G1LCC4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:PLAU ^@ http://purl.uniprot.org/uniprot/G1ME57 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:ELOVL4 ^@ http://purl.uniprot.org/uniprot/D2H3V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Membrane http://togogenome.org/gene/9646:PARPBP ^@ http://purl.uniprot.org/uniprot/A0A7N5JFL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PARI family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:PSMB4 ^@ http://purl.uniprot.org/uniprot/G1L1C8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1B family.|||Cytoplasm|||Non-catalytic component of the proteasome.|||Nucleus http://togogenome.org/gene/9646:DNAJB14 ^@ http://purl.uniprot.org/uniprot/D2HYU0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:EIF2B2 ^@ http://purl.uniprot.org/uniprot/D2GZX4 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/9646:SLC25A47 ^@ http://purl.uniprot.org/uniprot/G1LXA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9646:ARMC8 ^@ http://purl.uniprot.org/uniprot/A0A7N5KLR1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9646:LOC100478021 ^@ http://purl.uniprot.org/uniprot/D2I470 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:CTBS ^@ http://purl.uniprot.org/uniprot/G1L0J6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 18 family.|||Lysosome http://togogenome.org/gene/9646:SLC12A9 ^@ http://purl.uniprot.org/uniprot/D2HX03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9646:TRPV5 ^@ http://purl.uniprot.org/uniprot/D2HP40 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9646:WASF1 ^@ http://purl.uniprot.org/uniprot/D2HSZ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCAR/WAVE family.|||Binds actin and the Arp2/3 complex.|||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|||cytoskeleton http://togogenome.org/gene/9646:SLC7A4 ^@ http://purl.uniprot.org/uniprot/G1LBQ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:LTA ^@ http://purl.uniprot.org/uniprot/D2I4B4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.|||Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. Interacts with TNFRSF14.|||Membrane|||Secreted http://togogenome.org/gene/9646:GNS ^@ http://purl.uniprot.org/uniprot/G1MIJ5 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Lysosome|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9646:MPP5 ^@ http://purl.uniprot.org/uniprot/D2HRH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Cell membrane|||Endomembrane system|||adherens junction|||tight junction http://togogenome.org/gene/9646:PTGER3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JXX2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9646:API5 ^@ http://purl.uniprot.org/uniprot/A0A7N5JBE5 ^@ Similarity ^@ Belongs to the API5 family. http://togogenome.org/gene/9646:MMRN1 ^@ http://purl.uniprot.org/uniprot/G1M961 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:LOC100483758 ^@ http://purl.uniprot.org/uniprot/G1L550 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9646:RPS14 ^@ http://purl.uniprot.org/uniprot/D9ZLV2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/9646:RPN2 ^@ http://purl.uniprot.org/uniprot/G1M118 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SWP1 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/9646:CFAP299 ^@ http://purl.uniprot.org/uniprot/G1LF41 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in spermatogenesis.|||Nucleus http://togogenome.org/gene/9646:HSPA8 ^@ http://purl.uniprot.org/uniprot/D2GYC0 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9646:SLC35A4 ^@ http://purl.uniprot.org/uniprot/D2GUP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:HSPA2 ^@ http://purl.uniprot.org/uniprot/D2GYI3 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9646:MX1 ^@ http://purl.uniprot.org/uniprot/A0A7N5K8P8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.|||Cytoplasm http://togogenome.org/gene/9646:ILVBL ^@ http://purl.uniprot.org/uniprot/D2HZA5|||http://purl.uniprot.org/uniprot/G1L6T9 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/9646:CLDN12 ^@ http://purl.uniprot.org/uniprot/D2HE11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Membrane|||tight junction http://togogenome.org/gene/9646:RORC ^@ http://purl.uniprot.org/uniprot/G1L0N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9646:FGF14 ^@ http://purl.uniprot.org/uniprot/G1MDQ3 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9646:AQP8 ^@ http://purl.uniprot.org/uniprot/A0A7N5K324 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:GLA ^@ http://purl.uniprot.org/uniprot/D2I2M9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 27 family.|||Homodimer.|||Lysosome http://togogenome.org/gene/9646:AHSA1 ^@ http://purl.uniprot.org/uniprot/D2HUS1 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/9646:HLF ^@ http://purl.uniprot.org/uniprot/D2HSP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/9646:YIPF4 ^@ http://purl.uniprot.org/uniprot/G1LM66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:APOC3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JMU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the apolipoprotein C3 family.|||Secreted http://togogenome.org/gene/9646:NTF3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JN60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NGF-beta family.|||Secreted|||Seems to promote the survival of visceral and proprioceptive sensory neurons. http://togogenome.org/gene/9646:RGS3 ^@ http://purl.uniprot.org/uniprot/A0A7N5P9P1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:ARF4 ^@ http://purl.uniprot.org/uniprot/G1LZB6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/9646:FGF9 ^@ http://purl.uniprot.org/uniprot/D2I195 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9646:ENTPD5 ^@ http://purl.uniprot.org/uniprot/A0A7N5JSB4 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9646:SAP18 ^@ http://purl.uniprot.org/uniprot/G1M7X4 ^@ Similarity ^@ Belongs to the SAP18 family. http://togogenome.org/gene/9646:LOC100476962 ^@ http://purl.uniprot.org/uniprot/G1L9T8 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/9646:ID2 ^@ http://purl.uniprot.org/uniprot/D2HLK9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:GPR1 ^@ http://purl.uniprot.org/uniprot/G1L8E5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:EDEM2 ^@ http://purl.uniprot.org/uniprot/D2H444 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9646:MAML2 ^@ http://purl.uniprot.org/uniprot/G1LMX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mastermind family.|||Nucleus speckle http://togogenome.org/gene/9646:NPTXR ^@ http://purl.uniprot.org/uniprot/G1LWA7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:ACTBL2 ^@ http://purl.uniprot.org/uniprot/D2HU13 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9646:DUSP1 ^@ http://purl.uniprot.org/uniprot/D2H5F0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/9646:CHL1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KDX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.|||Cell membrane http://togogenome.org/gene/9646:GUCY1A1 ^@ http://purl.uniprot.org/uniprot/D2HPI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Cytoplasm http://togogenome.org/gene/9646:DECR2 ^@ http://purl.uniprot.org/uniprot/D2HDW2 ^@ Similarity|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.|||Monomer, dimer and oligomer. http://togogenome.org/gene/9646:EEF1AKMT2 ^@ http://purl.uniprot.org/uniprot/G1LBZ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.|||Cytoplasm|||Nucleus|||Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'. http://togogenome.org/gene/9646:CFAP298 ^@ http://purl.uniprot.org/uniprot/D2HCH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP298 family.|||cilium basal body http://togogenome.org/gene/9646:SPTLC2 ^@ http://purl.uniprot.org/uniprot/D2HUS2 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9646:LAMC2 ^@ http://purl.uniprot.org/uniprot/G1L6E0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||basement membrane http://togogenome.org/gene/9646:KCNH5 ^@ http://purl.uniprot.org/uniprot/A0A7N5P2X6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:LOC100463849 ^@ http://purl.uniprot.org/uniprot/D2HSF7 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/9646:KEG54_p05 ^@ http://purl.uniprot.org/uniprot/A5JFK4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 4L family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9646:TRAPPC3L ^@ http://purl.uniprot.org/uniprot/G1LGE7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||Homodimer.|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||cis-Golgi network http://togogenome.org/gene/9646:FRRS1 ^@ http://purl.uniprot.org/uniprot/G1LRB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FRRS1 family.|||Membrane http://togogenome.org/gene/9646:BCLAF1 ^@ http://purl.uniprot.org/uniprot/G1LTX4 ^@ Similarity ^@ Belongs to the BCLAF1/THRAP3 family. http://togogenome.org/gene/9646:ELAVL2 ^@ http://purl.uniprot.org/uniprot/A0A7N5K9T7 ^@ Similarity ^@ Belongs to the RRM elav family. http://togogenome.org/gene/9646:DMRTC2 ^@ http://purl.uniprot.org/uniprot/D2HNF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/9646:ACER2 ^@ http://purl.uniprot.org/uniprot/D2H9N1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:TMEM176A ^@ http://purl.uniprot.org/uniprot/G1M638 ^@ Similarity ^@ Belongs to the TMEM176 family. http://togogenome.org/gene/9646:ZP4 ^@ http://purl.uniprot.org/uniprot/G1L8A3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZP domain family. ZPB subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Zona pellucida http://togogenome.org/gene/9646:EPOR ^@ http://purl.uniprot.org/uniprot/D2HGW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||Membrane http://togogenome.org/gene/9646:RNF4 ^@ http://purl.uniprot.org/uniprot/G1M732 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:ADSL ^@ http://purl.uniprot.org/uniprot/G1LX74 ^@ Function|||Similarity|||Subunit ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.|||Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site. http://togogenome.org/gene/9646:RPS16 ^@ http://purl.uniprot.org/uniprot/F0UY67 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/9646:LOC100484809 ^@ http://purl.uniprot.org/uniprot/D2I0A4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9646:SLC25A32 ^@ http://purl.uniprot.org/uniprot/A0A7N5K686 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9646:ACSL5 ^@ http://purl.uniprot.org/uniprot/G1MAK4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.|||Endoplasmic reticulum membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9646:APLNR ^@ http://purl.uniprot.org/uniprot/D2HK54 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:PTGFR ^@ http://purl.uniprot.org/uniprot/A0A7N5JGI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:SDHAF1 ^@ http://purl.uniprot.org/uniprot/D2HFT9 ^@ Similarity ^@ Belongs to the complex I LYR family. SDHAF1 subfamily. http://togogenome.org/gene/9646:HCN3 ^@ http://purl.uniprot.org/uniprot/D2HZK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel HCN family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:ZSCAN29 ^@ http://purl.uniprot.org/uniprot/D2GW56 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9646:TAMM41 ^@ http://purl.uniprot.org/uniprot/G1LWW4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TAM41 family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:HTR2B ^@ http://purl.uniprot.org/uniprot/D2H6T9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||synaptosome http://togogenome.org/gene/9646:HTATSF1 ^@ http://purl.uniprot.org/uniprot/A0A7N5P5E3|||http://purl.uniprot.org/uniprot/G1L863 ^@ Similarity ^@ Belongs to the HTATSF1 family. http://togogenome.org/gene/9646:GPD2 ^@ http://purl.uniprot.org/uniprot/D2HUI8 ^@ Function|||Similarity ^@ Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.|||Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device. http://togogenome.org/gene/9646:C5AR2 ^@ http://purl.uniprot.org/uniprot/D2HL40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chemokine-like receptor (CMKLR) family.|||Membrane http://togogenome.org/gene/9646:PEX2 ^@ http://purl.uniprot.org/uniprot/D2HKR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pex2/pex10/pex12 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9646:MIS12 ^@ http://purl.uniprot.org/uniprot/D2I1J3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mis12 family.|||Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3, CBX5, NDC80 and ZWINT.|||kinetochore http://togogenome.org/gene/9646:SLC5A2 ^@ http://purl.uniprot.org/uniprot/D2HTD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:TRIM56 ^@ http://purl.uniprot.org/uniprot/D2I5Z5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm http://togogenome.org/gene/9646:RFT1 ^@ http://purl.uniprot.org/uniprot/G1LN22 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RFT1 family.|||May be involved in N-linked oligosaccharide assembly.|||Membrane http://togogenome.org/gene/9646:PGLYRP1 ^@ http://purl.uniprot.org/uniprot/G1L198 ^@ Function|||Similarity ^@ Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.|||Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. http://togogenome.org/gene/9646:PARP8 ^@ http://purl.uniprot.org/uniprot/A0A7N5K0P6 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9646:WASF2 ^@ http://purl.uniprot.org/uniprot/D2GWI9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCAR/WAVE family.|||Binds actin and the Arp2/3 complex.|||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|||cytoskeleton http://togogenome.org/gene/9646:POLR3G ^@ http://purl.uniprot.org/uniprot/D2GX78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC7 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/9646:PDCD10 ^@ http://purl.uniprot.org/uniprot/D2H6S8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDCD10 family.|||Cell membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:LOC100484841 ^@ http://purl.uniprot.org/uniprot/G1LN39 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCR10/QCR9 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9646:CDH9 ^@ http://purl.uniprot.org/uniprot/D2H5S4 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:LOC100476246 ^@ http://purl.uniprot.org/uniprot/G1M990 ^@ Similarity ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. http://togogenome.org/gene/9646:HYAL2 ^@ http://purl.uniprot.org/uniprot/D2HES7|||http://purl.uniprot.org/uniprot/G1LZ03 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/9646:TRPM8 ^@ http://purl.uniprot.org/uniprot/G1MCC6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:GJA4 ^@ http://purl.uniprot.org/uniprot/D2H618 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9646:SLC25A27 ^@ http://purl.uniprot.org/uniprot/A0A7N5KLE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9646:HDHD2 ^@ http://purl.uniprot.org/uniprot/G1M2C4 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/9646:IFNB1 ^@ http://purl.uniprot.org/uniprot/D2H9N6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9646:CDX4 ^@ http://purl.uniprot.org/uniprot/D2I4Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Caudal homeobox family.|||Nucleus http://togogenome.org/gene/9646:RPL32 ^@ http://purl.uniprot.org/uniprot/F2X278 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/9646:LOC100476018 ^@ http://purl.uniprot.org/uniprot/D2I3R4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:PSMA3 ^@ http://purl.uniprot.org/uniprot/G1L6X6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9646:TAC1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JLI8|||http://purl.uniprot.org/uniprot/G1MD15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tachykinin family.|||Secreted|||Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. http://togogenome.org/gene/9646:AR ^@ http://purl.uniprot.org/uniprot/D2I1X7 ^@ Similarity ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily. http://togogenome.org/gene/9646:LOC100473415 ^@ http://purl.uniprot.org/uniprot/D2GW51 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/9646:LOC100472783 ^@ http://purl.uniprot.org/uniprot/D2HP43 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:INHBA ^@ http://purl.uniprot.org/uniprot/D2GYF9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/9646:RPS12 ^@ http://purl.uniprot.org/uniprot/F2X216 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS12 family. http://togogenome.org/gene/9646:NAPB ^@ http://purl.uniprot.org/uniprot/G1LTJ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/9646:CCL17 ^@ http://purl.uniprot.org/uniprot/A0A7N5JJY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9646:DIPK2B ^@ http://purl.uniprot.org/uniprot/D2I209 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Secreted http://togogenome.org/gene/9646:KCNA5 ^@ http://purl.uniprot.org/uniprot/D2HEJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:PRORP ^@ http://purl.uniprot.org/uniprot/A0A7N5K0J7 ^@ Similarity ^@ Belongs to the PPR family. P subfamily. http://togogenome.org/gene/9646:EOGT ^@ http://purl.uniprot.org/uniprot/D2HPQ6 ^@ Similarity ^@ Belongs to the glycosyltransferase 61 family. http://togogenome.org/gene/9646:CHN1 ^@ http://purl.uniprot.org/uniprot/G1M0W4 ^@ Function ^@ GTPase-activating protein for p21-rac. http://togogenome.org/gene/9646:ESX1 ^@ http://purl.uniprot.org/uniprot/G1L0R5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:MRPS21 ^@ http://purl.uniprot.org/uniprot/D2HBU5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/9646:GUF1 ^@ http://purl.uniprot.org/uniprot/G1MCA9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding elongation factor family. LepA subfamily.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Mitochondrion inner membrane|||Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. http://togogenome.org/gene/9646:PPP2R5B ^@ http://purl.uniprot.org/uniprot/A0A7N5KL86|||http://purl.uniprot.org/uniprot/D2H4S3 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9646:NRN1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KDJ5 ^@ Similarity ^@ Belongs to the neuritin family. http://togogenome.org/gene/9646:IRF4 ^@ http://purl.uniprot.org/uniprot/D2I4K6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:SCG3 ^@ http://purl.uniprot.org/uniprot/G1LRU2 ^@ Subcellular Location Annotation ^@ Membrane|||Secreted|||secretory vesicle membrane http://togogenome.org/gene/9646:LOC100476924 ^@ http://purl.uniprot.org/uniprot/A0A7N5P342 ^@ Similarity ^@ Belongs to the glycine N-acyltransferase family. http://togogenome.org/gene/9646:SLC6A18 ^@ http://purl.uniprot.org/uniprot/G1LVK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9646:ADIPOR1 ^@ http://purl.uniprot.org/uniprot/D2HSE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9646:GEM ^@ http://purl.uniprot.org/uniprot/A0A7N5KAI4 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/9646:CAVIN1 ^@ http://purl.uniprot.org/uniprot/D2HIT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/9646:METTL3 ^@ http://purl.uniprot.org/uniprot/D2HYB7 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/9646:MPC2 ^@ http://purl.uniprot.org/uniprot/G1LI57 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9646:B4GALT3 ^@ http://purl.uniprot.org/uniprot/D2I0T2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9646:TDO2 ^@ http://purl.uniprot.org/uniprot/G1MAF5 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the tryptophan 2,3-dioxygenase family.|||Binds 1 heme group per subunit.|||Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.|||Homotetramer. Dimer of dimers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:MGAT1 ^@ http://purl.uniprot.org/uniprot/D2I5F9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 13 family.|||Golgi apparatus membrane|||Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.|||Membrane|||The cofactor is mostly bound to the substrate. http://togogenome.org/gene/9646:LOC100474511 ^@ http://purl.uniprot.org/uniprot/D2I697 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:GABRA1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JDL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9646:ZC3HC1 ^@ http://purl.uniprot.org/uniprot/G1LFR0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:CANX ^@ http://purl.uniprot.org/uniprot/G1LQL2 ^@ Similarity ^@ Belongs to the calreticulin family. http://togogenome.org/gene/9646:SLC37A3 ^@ http://purl.uniprot.org/uniprot/G1MHM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Membrane http://togogenome.org/gene/9646:SLC25A39 ^@ http://purl.uniprot.org/uniprot/G1MJ63 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:FUT8 ^@ http://purl.uniprot.org/uniprot/D2GYH5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 23 family.|||Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9646:ITGA10 ^@ http://purl.uniprot.org/uniprot/G1MGX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9646:TCP11L2 ^@ http://purl.uniprot.org/uniprot/G1MC30 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/9646:GOLGA5 ^@ http://purl.uniprot.org/uniprot/D2HN66 ^@ Function|||Subcellular Location Annotation ^@ Golgi apparatus membrane|||Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. http://togogenome.org/gene/9646:SLC41A1 ^@ http://purl.uniprot.org/uniprot/D2I002 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/9646:RPTOR ^@ http://purl.uniprot.org/uniprot/G1MA15 ^@ Similarity ^@ Belongs to the WD repeat RAPTOR family. http://togogenome.org/gene/9646:FAM8A1 ^@ http://purl.uniprot.org/uniprot/D2HW99 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:MINDY3 ^@ http://purl.uniprot.org/uniprot/D2I688 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM188 subfamily.|||Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. http://togogenome.org/gene/9646:ST13 ^@ http://purl.uniprot.org/uniprot/D2HWC9 ^@ Similarity ^@ Belongs to the FAM10 family. http://togogenome.org/gene/9646:TMBIM1 ^@ http://purl.uniprot.org/uniprot/D2GXE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9646:SPIC ^@ http://purl.uniprot.org/uniprot/A0A7N5JLJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9646:AVPR1A ^@ http://purl.uniprot.org/uniprot/A0A7N5P086 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane|||Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. http://togogenome.org/gene/9646:KIF5C ^@ http://purl.uniprot.org/uniprot/A0A7N5KD14 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9646:LSM12 ^@ http://purl.uniprot.org/uniprot/D2HCU6 ^@ Similarity ^@ Belongs to the LSM12 family. http://togogenome.org/gene/9646:YIPF2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JWL2|||http://purl.uniprot.org/uniprot/G1LWW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Endosome membrane|||Golgi apparatus membrane|||Late endosome membrane|||Membrane|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/9646:TPMT ^@ http://purl.uniprot.org/uniprot/D2HIB1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9646:RAB4B ^@ http://purl.uniprot.org/uniprot/G1M0L3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. http://togogenome.org/gene/9646:TGFB2 ^@ http://purl.uniprot.org/uniprot/A0A7N5KEX5|||http://purl.uniprot.org/uniprot/D2HL87 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.|||extracellular matrix http://togogenome.org/gene/9646:SLC17A1 ^@ http://purl.uniprot.org/uniprot/G1LTP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.|||Membrane http://togogenome.org/gene/9646:ARL4D ^@ http://purl.uniprot.org/uniprot/D2HCT5 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9646:IPPK ^@ http://purl.uniprot.org/uniprot/D2HY02 ^@ Domain|||Function|||Similarity ^@ Belongs to the IPK1 type 2 family.|||Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).|||The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2. http://togogenome.org/gene/9646:ALG11 ^@ http://purl.uniprot.org/uniprot/G1LZH2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.|||Endoplasmic reticulum membrane|||Required for N-linked oligosaccharide assembly. http://togogenome.org/gene/9646:SERINC4 ^@ http://purl.uniprot.org/uniprot/G1M9L2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9646:POLR2G ^@ http://purl.uniprot.org/uniprot/G1LIJ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.|||DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/9646:BUD23 ^@ http://purl.uniprot.org/uniprot/G1LXT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:LOC117795019 ^@ http://purl.uniprot.org/uniprot/D2HU52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZHX family.|||Nucleus http://togogenome.org/gene/9646:PCK1 ^@ http://purl.uniprot.org/uniprot/D2H1Y7 ^@ Similarity ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. http://togogenome.org/gene/9646:RAPGEF2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JEP7|||http://purl.uniprot.org/uniprot/A0A7N5K7K6|||http://purl.uniprot.org/uniprot/A0A7N5K9E6|||http://purl.uniprot.org/uniprot/A0A7N5PAJ0|||http://purl.uniprot.org/uniprot/A0A7N5PAK5|||http://purl.uniprot.org/uniprot/G1L6X3 ^@ Similarity ^@ Belongs to the RAPGEF2 family. http://togogenome.org/gene/9646:SF3B3 ^@ http://purl.uniprot.org/uniprot/G1L613 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:TSFM ^@ http://purl.uniprot.org/uniprot/G1LFS1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Mitochondrion http://togogenome.org/gene/9646:LOC100483311 ^@ http://purl.uniprot.org/uniprot/D2I7N0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:SPOUT1 ^@ http://purl.uniprot.org/uniprot/G1MBF5 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. http://togogenome.org/gene/9646:TMEM86B ^@ http://purl.uniprot.org/uniprot/G1LA30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM86 family.|||Membrane http://togogenome.org/gene/9646:DERL1 ^@ http://purl.uniprot.org/uniprot/D2HU53 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Membrane http://togogenome.org/gene/9646:RAB33A ^@ http://purl.uniprot.org/uniprot/D2H9U8 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Rab family. http://togogenome.org/gene/9646:NMUR2 ^@ http://purl.uniprot.org/uniprot/G1LMG7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for the neuromedin-U and neuromedin-S neuropeptides. http://togogenome.org/gene/9646:RPL19 ^@ http://purl.uniprot.org/uniprot/F2X258 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/9646:SLC25A38 ^@ http://purl.uniprot.org/uniprot/A0A7N5JEP1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.|||Membrane|||Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.|||Mitochondrion inner membrane|||Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis. http://togogenome.org/gene/9646:LOC100477332 ^@ http://purl.uniprot.org/uniprot/D2HKT4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:FABP6 ^@ http://purl.uniprot.org/uniprot/A0A7N5JY50 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9646:PNLIPRP1 ^@ http://purl.uniprot.org/uniprot/G1M5Y7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9646:LOC100481536 ^@ http://purl.uniprot.org/uniprot/G1MJG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/9646:ANP32A ^@ http://purl.uniprot.org/uniprot/G1M6B7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANP32 family.|||Multifunctional protein that is involved in the regulation of many processes.|||Nucleus http://togogenome.org/gene/9646:KIF19 ^@ http://purl.uniprot.org/uniprot/G1L3F0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9646:LOC100472721 ^@ http://purl.uniprot.org/uniprot/A0A7N5J8E2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:ATR ^@ http://purl.uniprot.org/uniprot/G1M1R0 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. ATM subfamily. http://togogenome.org/gene/9646:CEMIP2 ^@ http://purl.uniprot.org/uniprot/D2H003 ^@ Similarity ^@ Belongs to the CEMIP family. http://togogenome.org/gene/9646:TBX15 ^@ http://purl.uniprot.org/uniprot/D2HZH8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9646:GRK5 ^@ http://purl.uniprot.org/uniprot/A0A7N5KNA1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9646:ACTR1A ^@ http://purl.uniprot.org/uniprot/A0A7N5K5G5 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9646:LOC100469032 ^@ http://purl.uniprot.org/uniprot/D2HX82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lambda interferon family.|||Secreted http://togogenome.org/gene/9646:TAF9B ^@ http://purl.uniprot.org/uniprot/G1MGX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF9 family.|||Nucleus http://togogenome.org/gene/9646:ERLIN2 ^@ http://purl.uniprot.org/uniprot/D2H695 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the band 7/mec-2 family.|||Endoplasmic reticulum membrane|||Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.|||Membrane http://togogenome.org/gene/9646:DRD1 ^@ http://purl.uniprot.org/uniprot/D2HHS8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.|||Membrane|||dendritic spine http://togogenome.org/gene/9646:KLHL15 ^@ http://purl.uniprot.org/uniprot/A0A7N5JVU6|||http://purl.uniprot.org/uniprot/D2HXJ7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:LXN ^@ http://purl.uniprot.org/uniprot/D2HAE3 ^@ Similarity ^@ Belongs to the protease inhibitor I47 (latexin) family. http://togogenome.org/gene/9646:NDST1 ^@ http://purl.uniprot.org/uniprot/G1LDA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/9646:TAF7 ^@ http://purl.uniprot.org/uniprot/G1MP83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF7 family.|||Nucleus http://togogenome.org/gene/9646:LOC100479700 ^@ http://purl.uniprot.org/uniprot/A0A7N5P7H0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9646:B3GALT2 ^@ http://purl.uniprot.org/uniprot/D2HM04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:AFG1L ^@ http://purl.uniprot.org/uniprot/G1LNE7 ^@ Similarity ^@ Belongs to the AFG1 ATPase family. http://togogenome.org/gene/9646:EIF5 ^@ http://purl.uniprot.org/uniprot/G1MIN3 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/9646:TCEANC2 ^@ http://purl.uniprot.org/uniprot/G1LT51 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:PHACTR1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JY80 ^@ Similarity|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin. http://togogenome.org/gene/9646:ORMDL3 ^@ http://purl.uniprot.org/uniprot/D2I2F3 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORM family.|||Ceramide-sensitive subunit of the serine palmitoyltransferase (SPT) complex, which is also composed of SPTLC1, SPTLC2/3 and SPTSSA/B.|||Ceramides bind to ORMDL3 N-terminus and stabilize it in a conformation that physically restricts the accessibility of the substrates to their binding sites in the serine palmitoyltransferase (SPT) complex, hence inhibiting SPT catalytic activity. In the absence of ceramides, the N-terminus is flexible and permits substrate binding, thus liberating SPT from inhibition.|||Endoplasmic reticulum membrane|||Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels. When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis.|||When hydroxylated at Pro-137, ubiquitinated via 'Lys-48'-linkage, leading to proteasomal degradation. In endothelial cells, ORMDL3 proteasomal degradation is controlled by the sphingosine 1-phosphate receptor signaling pathway. http://togogenome.org/gene/9646:SENP5 ^@ http://purl.uniprot.org/uniprot/A0A7N5P2J3|||http://purl.uniprot.org/uniprot/D2H4X5|||http://purl.uniprot.org/uniprot/G1LAH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C48 family.|||nucleolus http://togogenome.org/gene/9646:LOC100468240 ^@ http://purl.uniprot.org/uniprot/A0A7N5JUT3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:SCN3B ^@ http://purl.uniprot.org/uniprot/A0A7N5JKX9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.|||Membrane|||Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. http://togogenome.org/gene/9646:AQP9 ^@ http://purl.uniprot.org/uniprot/D2HF57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:MSRB2 ^@ http://purl.uniprot.org/uniprot/G1LIG2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Binds 1 zinc ion per subunit.|||Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. http://togogenome.org/gene/9646:PIK3C2A ^@ http://purl.uniprot.org/uniprot/D2HRK9 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9646:POU2F2 ^@ http://purl.uniprot.org/uniprot/A0A7N5KHW1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-2 subfamily.|||Nucleus|||Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. http://togogenome.org/gene/9646:NBR1 ^@ http://purl.uniprot.org/uniprot/G1KZY2 ^@ Subcellular Location Annotation ^@ Lysosome|||autophagosome http://togogenome.org/gene/9646:PWWP3B ^@ http://purl.uniprot.org/uniprot/G1MK03 ^@ Similarity ^@ Belongs to the PWWP3A family. http://togogenome.org/gene/9646:BHMT ^@ http://purl.uniprot.org/uniprot/G1LGI1 ^@ Cofactor|||Function|||Subunit ^@ Binds 1 zinc ion per subunit.|||Homotetramer.|||Involved in the regulation of homocysteine metabolism. http://togogenome.org/gene/9646:ABHD3 ^@ http://purl.uniprot.org/uniprot/G1L745 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/9646:FARSA ^@ http://purl.uniprot.org/uniprot/G1M1C2 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily. http://togogenome.org/gene/9646:FABP7 ^@ http://purl.uniprot.org/uniprot/A0A7N5P874 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9646:LOC100476252 ^@ http://purl.uniprot.org/uniprot/D2HV26 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/9646:ENPEP ^@ http://purl.uniprot.org/uniprot/G1M8R9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit.|||Membrane http://togogenome.org/gene/9646:EMC2 ^@ http://purl.uniprot.org/uniprot/G1M2I0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC2 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. http://togogenome.org/gene/9646:LOC100481956 ^@ http://purl.uniprot.org/uniprot/A0A7N5KKQ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:ALX1 ^@ http://purl.uniprot.org/uniprot/D2HVJ0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:STARD3 ^@ http://purl.uniprot.org/uniprot/D2I2G2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STARD3 family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9646:SPSB2 ^@ http://purl.uniprot.org/uniprot/D2HJ04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPSB family.|||Cytoplasm http://togogenome.org/gene/9646:MASTL ^@ http://purl.uniprot.org/uniprot/D2HXI8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.|||Nucleus|||Phosphorylation at Thr-744 by CDK1 during M phase activates its kinase activity. Maximum phosphorylation occurs in prometaphase (By similarity).|||Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited (By similarity).|||centrosome http://togogenome.org/gene/9646:LOC100463732 ^@ http://purl.uniprot.org/uniprot/A0A7N5JYG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9646:ART3 ^@ http://purl.uniprot.org/uniprot/A0A7N5P680 ^@ Similarity ^@ Belongs to the Arg-specific ADP-ribosyltransferase family. http://togogenome.org/gene/9646:GSTO2 ^@ http://purl.uniprot.org/uniprot/G1MI73 ^@ Function|||Similarity ^@ Belongs to the GST superfamily. Omega family.|||Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). http://togogenome.org/gene/9646:GHITM ^@ http://purl.uniprot.org/uniprot/G1LT79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9646:GPR4 ^@ http://purl.uniprot.org/uniprot/D2I073 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:GRIA1 ^@ http://purl.uniprot.org/uniprot/A0A7N5K735|||http://purl.uniprot.org/uniprot/G1M786 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9646:RPL10A ^@ http://purl.uniprot.org/uniprot/F2X244 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL1 family. http://togogenome.org/gene/9646:TLL1 ^@ http://purl.uniprot.org/uniprot/D2HGS4|||http://purl.uniprot.org/uniprot/G1LER7 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:LMLN ^@ http://purl.uniprot.org/uniprot/G1LC10 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M8 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9646:G6PC2 ^@ http://purl.uniprot.org/uniprot/A0A7N5KAW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9646:CFAP126 ^@ http://purl.uniprot.org/uniprot/G1MA04 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the Flattop family. http://togogenome.org/gene/9646:KCNV2 ^@ http://purl.uniprot.org/uniprot/D2HB59 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:TMEM147 ^@ http://purl.uniprot.org/uniprot/D2HFR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM147 family.|||Cell membrane|||Endoplasmic reticulum membrane|||Membrane|||Nucleus membrane http://togogenome.org/gene/9646:FLCN ^@ http://purl.uniprot.org/uniprot/A0A7N5JRA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the folliculin family.|||Lysosome membrane|||Membrane|||Nucleus|||centrosome|||cilium|||cytosol|||spindle http://togogenome.org/gene/9646:NF2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JT76|||http://purl.uniprot.org/uniprot/A0A7N5JZ14|||http://purl.uniprot.org/uniprot/G1LNC1 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton|||microvillus http://togogenome.org/gene/9646:ATG5 ^@ http://purl.uniprot.org/uniprot/D2HSI9|||http://purl.uniprot.org/uniprot/G1L3Y1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG5 family.|||Conjugated with ATG12.|||Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.|||May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.|||Preautophagosomal structure membrane http://togogenome.org/gene/9646:LRP12 ^@ http://purl.uniprot.org/uniprot/A0A7N5P8Z8|||http://purl.uniprot.org/uniprot/D2H6W6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:MCIDAS ^@ http://purl.uniprot.org/uniprot/G1LS83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the geminin family.|||Nucleus http://togogenome.org/gene/9646:NAP1L2 ^@ http://purl.uniprot.org/uniprot/D2I4Q9 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9646:LOC100474824 ^@ http://purl.uniprot.org/uniprot/D2HP54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9646:C9H8orf37 ^@ http://purl.uniprot.org/uniprot/D2HVB4 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in photoreceptor outer segment disk morphogenesis.|||Photoreceptor inner segment http://togogenome.org/gene/9646:SPCS1 ^@ http://purl.uniprot.org/uniprot/G1LP81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:TM9SF4 ^@ http://purl.uniprot.org/uniprot/G1M4A2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/9646:CNPY2 ^@ http://purl.uniprot.org/uniprot/D2H353 ^@ Similarity ^@ Belongs to the canopy family. http://togogenome.org/gene/9646:SLC35A5 ^@ http://purl.uniprot.org/uniprot/G1MIF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:ELP6 ^@ http://purl.uniprot.org/uniprot/G1M2X7 ^@ Similarity ^@ Belongs to the ELP6 family. http://togogenome.org/gene/9646:CD5L ^@ http://purl.uniprot.org/uniprot/G1LCQ8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:PPP1R3C ^@ http://purl.uniprot.org/uniprot/A0A7N5P0W8 ^@ Domain|||Function|||Subunit ^@ Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.|||Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.|||The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase. http://togogenome.org/gene/9646:HDAC3 ^@ http://purl.uniprot.org/uniprot/G1LVB1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.|||Nucleus http://togogenome.org/gene/9646:RPS11 ^@ http://purl.uniprot.org/uniprot/D3YC01 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/9646:LEF1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JPK5|||http://purl.uniprot.org/uniprot/A0A7N5JQR6|||http://purl.uniprot.org/uniprot/A0A7N5KEC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCF/LEF family.|||Nucleus http://togogenome.org/gene/9646:CDCA7 ^@ http://purl.uniprot.org/uniprot/G1L090 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9646:FAM53C ^@ http://purl.uniprot.org/uniprot/D2HK95 ^@ Similarity ^@ Belongs to the FAM53 family. http://togogenome.org/gene/9646:FZD1 ^@ http://purl.uniprot.org/uniprot/D2HY60 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:LOC100471200 ^@ http://purl.uniprot.org/uniprot/A0A7N5P0W1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:ACAA2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JFE7 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/9646:ZFYVE26 ^@ http://purl.uniprot.org/uniprot/D2H5P6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ZFYVE26 family.|||Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A (By similarity).|||Midbody|||Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair (By similarity).|||The FYVE-type zinc finger mediates binding to phosphatidylinositol 3-phosphate and recruitment to the midbody during cytokinesis.|||centrosome http://togogenome.org/gene/9646:CXCR6 ^@ http://purl.uniprot.org/uniprot/G1MM44 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:LAP3 ^@ http://purl.uniprot.org/uniprot/D2H3S4 ^@ Similarity|||Subunit ^@ Belongs to the peptidase M17 family.|||Homohexamer. http://togogenome.org/gene/9646:LDB1 ^@ http://purl.uniprot.org/uniprot/D2GXV5 ^@ Similarity ^@ Belongs to the LDB family. http://togogenome.org/gene/9646:TLE4 ^@ http://purl.uniprot.org/uniprot/G1LPR5 ^@ Similarity ^@ Belongs to the WD repeat Groucho/TLE family. http://togogenome.org/gene/9646:UCP2 ^@ http://purl.uniprot.org/uniprot/D2H1F0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9646:CFAP36 ^@ http://purl.uniprot.org/uniprot/G1LB50 ^@ Similarity ^@ Belongs to the CFAP36 family. http://togogenome.org/gene/9646:MCTP2 ^@ http://purl.uniprot.org/uniprot/G1MBL6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:B3GNT4 ^@ http://purl.uniprot.org/uniprot/G1MMP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:HOXD1 ^@ http://purl.uniprot.org/uniprot/D2I1F9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Labial subfamily.|||Nucleus http://togogenome.org/gene/9646:LOC100465394 ^@ http://purl.uniprot.org/uniprot/A0A7N5KEQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMN family.|||Cajal body|||Perikaryon|||Z line|||gem|||neuron projection http://togogenome.org/gene/9646:CDH1 ^@ http://purl.uniprot.org/uniprot/G1LMI4 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:LOC100469420 ^@ http://purl.uniprot.org/uniprot/A0A7N5JFV0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCRH/QCR6 family.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:PTTG1 ^@ http://purl.uniprot.org/uniprot/G1LJB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the securin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:LOC100478359 ^@ http://purl.uniprot.org/uniprot/G1LQU5 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/9646:ADRM1 ^@ http://purl.uniprot.org/uniprot/D2HT81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADRM1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:SLC14A1 ^@ http://purl.uniprot.org/uniprot/D2H8J4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urea transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:LOC100472740 ^@ http://purl.uniprot.org/uniprot/D2GYJ3 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9646:REEP2 ^@ http://purl.uniprot.org/uniprot/G1MDP1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:UTP6 ^@ http://purl.uniprot.org/uniprot/G1LFU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP6 family.|||nucleolus http://togogenome.org/gene/9646:BEST4 ^@ http://purl.uniprot.org/uniprot/D2HUP0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms calcium-sensitive chloride channels. Permeable to bicarbonate.|||Membrane http://togogenome.org/gene/9646:ABI1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KB61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABI family.|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/9646:DKK4 ^@ http://purl.uniprot.org/uniprot/D2H980 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/9646:DDX55 ^@ http://purl.uniprot.org/uniprot/D2GW00 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9646:XRCC6 ^@ http://purl.uniprot.org/uniprot/G1MAS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ku70 family.|||Nucleus http://togogenome.org/gene/9646:SNRNP27 ^@ http://purl.uniprot.org/uniprot/G1MCC9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNUT3 family.|||May play a role in mRNA splicing.|||Nucleus|||Part of a tri-snRNP complex. http://togogenome.org/gene/9646:STMN4 ^@ http://purl.uniprot.org/uniprot/A0A7N5JQA7|||http://purl.uniprot.org/uniprot/A0A7N5KK72|||http://purl.uniprot.org/uniprot/G1L025 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/9646:KCNJ14 ^@ http://purl.uniprot.org/uniprot/D2H7Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9646:WDR35 ^@ http://purl.uniprot.org/uniprot/G1L7P0 ^@ Function|||Subcellular Location Annotation ^@ As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking.|||centrosome|||cilium basal body http://togogenome.org/gene/9646:IL17B ^@ http://purl.uniprot.org/uniprot/A0A7N5JHK7|||http://purl.uniprot.org/uniprot/A0A7N5KGJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/9646:DAZAP2 ^@ http://purl.uniprot.org/uniprot/G1L5L5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus speckle|||nuclear body http://togogenome.org/gene/9646:DTNA ^@ http://purl.uniprot.org/uniprot/A0A7N5JQ06|||http://purl.uniprot.org/uniprot/A0A7N5K977|||http://purl.uniprot.org/uniprot/A0A7N5P786|||http://purl.uniprot.org/uniprot/G1L111 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dystrophin family. Dystrobrevin subfamily.|||Cytoplasm http://togogenome.org/gene/9646:SMC1B ^@ http://purl.uniprot.org/uniprot/G1LR03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC1 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/9646:ANP32E ^@ http://purl.uniprot.org/uniprot/G1L4W2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANP32 family.|||Multifunctional protein that is involved in the regulation of many processes.|||Nucleus http://togogenome.org/gene/9646:ISCU ^@ http://purl.uniprot.org/uniprot/G1MD98 ^@ Function|||Similarity ^@ Belongs to the NifU family.|||Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5. Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form. May modulate NFS1 desulfurase activity in a zinc-dependent manner. Modulates the interaction between FXN and the cysteine desulfurase complex. http://togogenome.org/gene/9646:NARF ^@ http://purl.uniprot.org/uniprot/A0A7N5JSD9 ^@ Similarity ^@ Belongs to the NARF family. http://togogenome.org/gene/9646:GCHFR ^@ http://purl.uniprot.org/uniprot/G1MEV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GFRP family.|||Membrane|||Nucleus membrane|||cytosol http://togogenome.org/gene/9646:LOC100475765 ^@ http://purl.uniprot.org/uniprot/D2I361 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9646:REEP6 ^@ http://purl.uniprot.org/uniprot/G1L8H3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/9646:HHIP ^@ http://purl.uniprot.org/uniprot/A0A7N5P717|||http://purl.uniprot.org/uniprot/D2H3P9 ^@ Caution|||Similarity ^@ Belongs to the HHIP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:CRYBA1 ^@ http://purl.uniprot.org/uniprot/G1LCF5 ^@ Function|||Similarity ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens. http://togogenome.org/gene/9646:CDK2 ^@ http://purl.uniprot.org/uniprot/A0A7N5KN52|||http://purl.uniprot.org/uniprot/D2H336 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9646:CSF1R ^@ http://purl.uniprot.org/uniprot/G1LEV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:NUSAP1 ^@ http://purl.uniprot.org/uniprot/G1MED5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NUSAP family.|||Cytoplasm http://togogenome.org/gene/9646:ITGB6 ^@ http://purl.uniprot.org/uniprot/A0A7N5P9I1|||http://purl.uniprot.org/uniprot/G1M1V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Melanosome|||Membrane|||Recycling endosome|||focal adhesion|||invadopodium membrane|||lamellipodium|||ruffle membrane http://togogenome.org/gene/9646:AP2S1 ^@ http://purl.uniprot.org/uniprot/E7BLG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cell membrane|||coated pit http://togogenome.org/gene/9646:AGBL5 ^@ http://purl.uniprot.org/uniprot/D2GXM8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||Binds 1 zinc ion per subunit.|||Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Cleaves alpha- and gamma-linked polyglutamate tubulin side-chain, as well as the branching point glutamate. Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin. Mediates deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation.|||Midbody|||Nucleus|||cytosol|||spindle http://togogenome.org/gene/9646:LOC100483310 ^@ http://purl.uniprot.org/uniprot/D2I7G9 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9646:RBP1 ^@ http://purl.uniprot.org/uniprot/G1MB88 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9646:LOC100465091 ^@ http://purl.uniprot.org/uniprot/D2HMU5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9646:BBS2 ^@ http://purl.uniprot.org/uniprot/G1ME56 ^@ Subcellular Location Annotation ^@ centriolar satellite|||cilium membrane http://togogenome.org/gene/9646:INTS14 ^@ http://purl.uniprot.org/uniprot/D2GYT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INTS14 family.|||Nucleus|||Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. http://togogenome.org/gene/9646:LIN7A ^@ http://purl.uniprot.org/uniprot/D2H508 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the lin-7 family.|||Cell membrane|||Lateral cell membrane|||Membrane|||Postsynaptic density membrane|||tight junction http://togogenome.org/gene/9646:ASB8 ^@ http://purl.uniprot.org/uniprot/D2HE78 ^@ Function ^@ May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/9646:CMTR1 ^@ http://purl.uniprot.org/uniprot/D2HRF1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with POLR2A (via C-terminus).|||Nucleus|||S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. http://togogenome.org/gene/9646:LDB3 ^@ http://purl.uniprot.org/uniprot/D2H1J8 ^@ Subcellular Location Annotation ^@ Z line http://togogenome.org/gene/9646:SMIM14 ^@ http://purl.uniprot.org/uniprot/A0A7N5P4H3|||http://purl.uniprot.org/uniprot/G1L8R2 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9646:RPL38 ^@ http://purl.uniprot.org/uniprot/F2X289 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL38 family. http://togogenome.org/gene/9646:CDH11 ^@ http://purl.uniprot.org/uniprot/D2HTK7 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:C4H19orf25 ^@ http://purl.uniprot.org/uniprot/G1L9K9 ^@ Similarity ^@ Belongs to the UPF0449 family. http://togogenome.org/gene/9646:LOC100466194 ^@ http://purl.uniprot.org/uniprot/D2HWJ3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9646:MRPL28 ^@ http://purl.uniprot.org/uniprot/G1LKE9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/9646:ATP1A1 ^@ http://purl.uniprot.org/uniprot/G1LEW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:PIPOX ^@ http://purl.uniprot.org/uniprot/D2GU14 ^@ Similarity ^@ Belongs to the MSOX/MTOX family. http://togogenome.org/gene/9646:POLR3D ^@ http://purl.uniprot.org/uniprot/D2H045 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:PIN4 ^@ http://purl.uniprot.org/uniprot/A0A7N5KIY9 ^@ Similarity ^@ Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily. http://togogenome.org/gene/9646:SENP3 ^@ http://purl.uniprot.org/uniprot/D2HPW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C48 family.|||nucleolus http://togogenome.org/gene/9646:SEC11A ^@ http://purl.uniprot.org/uniprot/A0A7N5K6S1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Component of the signal peptidase complex.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:SCGN ^@ http://purl.uniprot.org/uniprot/D2H2K4 ^@ Subcellular Location Annotation ^@ secretory vesicle membrane http://togogenome.org/gene/9646:SPIN1 ^@ http://purl.uniprot.org/uniprot/G1L9A6 ^@ Similarity ^@ Belongs to the SPIN/STSY family. http://togogenome.org/gene/9646:NIPAL1 ^@ http://purl.uniprot.org/uniprot/A0A7N5P626 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9646:DYNLL1 ^@ http://purl.uniprot.org/uniprot/D2I5D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/9646:ABL1 ^@ http://purl.uniprot.org/uniprot/D2H177 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane http://togogenome.org/gene/9646:LOC109488335 ^@ http://purl.uniprot.org/uniprot/G1MFN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Secreted http://togogenome.org/gene/9646:PLTP ^@ http://purl.uniprot.org/uniprot/G1M1Z4 ^@ Similarity ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. http://togogenome.org/gene/9646:GATA5 ^@ http://purl.uniprot.org/uniprot/D2HT78 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:ZDHHC15 ^@ http://purl.uniprot.org/uniprot/G1MGC4 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9646:EIF3L ^@ http://purl.uniprot.org/uniprot/A0A7N5JI21 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit L family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RRN3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm http://togogenome.org/gene/9646:PSPH ^@ http://purl.uniprot.org/uniprot/D2HTC5 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. SerB family. http://togogenome.org/gene/9646:RRP12 ^@ http://purl.uniprot.org/uniprot/D2H5L2 ^@ Similarity ^@ Belongs to the RRP12 family. http://togogenome.org/gene/9646:STX17 ^@ http://purl.uniprot.org/uniprot/D2H0F8 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9646:FAM167A ^@ http://purl.uniprot.org/uniprot/D2HMQ7 ^@ Similarity ^@ Belongs to the FAM167 (SEC) family. http://togogenome.org/gene/9646:GPR156 ^@ http://purl.uniprot.org/uniprot/D2H189 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:SHCBP1 ^@ http://purl.uniprot.org/uniprot/G1MJ48 ^@ Subcellular Location Annotation ^@ spindle http://togogenome.org/gene/9646:LOC100472056 ^@ http://purl.uniprot.org/uniprot/G1L8V2 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.|||Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane|||Interacts with chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria.|||Membrane|||Microsome membrane|||Mitochondrion inner membrane|||The omega-1 hydroxylase activity is stimulated by cytochrome b5. http://togogenome.org/gene/9646:LOC105235700 ^@ http://purl.uniprot.org/uniprot/A0A7N5JLB0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9646:SEC61B ^@ http://purl.uniprot.org/uniprot/A0A7N5JGR9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC61-beta family.|||Endoplasmic reticulum membrane|||Membrane|||Necessary for protein translocation in the endoplasmic reticulum. http://togogenome.org/gene/9646:EBNA1BP2 ^@ http://purl.uniprot.org/uniprot/D2HSR8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP2 family.|||Required for the processing of the 27S pre-rRNA.|||nucleolus http://togogenome.org/gene/9646:IL17A ^@ http://purl.uniprot.org/uniprot/A0A7N5KBI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/9646:SLC40A1 ^@ http://purl.uniprot.org/uniprot/G1M0K1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lateral cell membrane|||May be involved in iron transport and iron homeostasis.|||Membrane http://togogenome.org/gene/9646:COG7 ^@ http://purl.uniprot.org/uniprot/D2HWL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG7 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:LOC100476988 ^@ http://purl.uniprot.org/uniprot/D2HQF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/9646:TBCA ^@ http://purl.uniprot.org/uniprot/A0A7N5JCN0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TBCA family.|||Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.|||Tubulin-folding protein; involved in the early step of the tubulin folding pathway.|||cytoskeleton http://togogenome.org/gene/9646:PDE7B ^@ http://purl.uniprot.org/uniprot/A0A7N5KT71|||http://purl.uniprot.org/uniprot/G1LTS9 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9646:DNASE2 ^@ http://purl.uniprot.org/uniprot/G1M138 ^@ Similarity ^@ Belongs to the DNase II family. http://togogenome.org/gene/9646:FBL ^@ http://purl.uniprot.org/uniprot/G1M1Y1 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Fibrillarin family. http://togogenome.org/gene/9646:GTF2H4 ^@ http://purl.uniprot.org/uniprot/D2I123 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB2 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.|||Nucleus http://togogenome.org/gene/9646:FAM166A ^@ http://purl.uniprot.org/uniprot/G1MD64 ^@ Similarity ^@ Belongs to the CIMIP2 family. http://togogenome.org/gene/9646:SESN1 ^@ http://purl.uniprot.org/uniprot/D2H6J8|||http://purl.uniprot.org/uniprot/G1LNK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/9646:CLIC5 ^@ http://purl.uniprot.org/uniprot/A0A7N5JR74|||http://purl.uniprot.org/uniprot/A0A7N5KF61 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/9646:LOC100463574 ^@ http://purl.uniprot.org/uniprot/D2HHN3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:TLR2 ^@ http://purl.uniprot.org/uniprot/D2GXT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9646:S1PR2 ^@ http://purl.uniprot.org/uniprot/D2HGZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:CXCL13 ^@ http://purl.uniprot.org/uniprot/G1L6W7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9646:ERLIN1 ^@ http://purl.uniprot.org/uniprot/G1LK53 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the band 7/mec-2 family.|||Endoplasmic reticulum membrane|||Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.|||Membrane http://togogenome.org/gene/9646:DPH3 ^@ http://purl.uniprot.org/uniprot/A0A7N5K1V7 ^@ Similarity ^@ Belongs to the DPH3 family. http://togogenome.org/gene/9646:GFUS ^@ http://purl.uniprot.org/uniprot/D2HIP4 ^@ Function|||Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.|||Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. http://togogenome.org/gene/9646:GPR37 ^@ http://purl.uniprot.org/uniprot/D2HUB2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9646:RTN4 ^@ http://purl.uniprot.org/uniprot/A0A7N5P7W0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:GAS8 ^@ http://purl.uniprot.org/uniprot/G1L3Q6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC4 family.|||flagellum|||flagellum axoneme http://togogenome.org/gene/9646:MFAP1 ^@ http://purl.uniprot.org/uniprot/D2GW43 ^@ Function|||Similarity ^@ Belongs to the MFAP1 family.|||Involved in pre-mRNA splicing as a component of the spliceosome. http://togogenome.org/gene/9646:CFAP97D1 ^@ http://purl.uniprot.org/uniprot/G1MJ11 ^@ Similarity ^@ Belongs to the CFAP97 family. http://togogenome.org/gene/9646:CAPN3 ^@ http://purl.uniprot.org/uniprot/A0A7N5K5S6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C2 family.|||Calcium-regulated non-lysosomal thiol-protease.|||Cytoplasm|||Homodimer.|||nucleolus http://togogenome.org/gene/9646:MEPCE ^@ http://purl.uniprot.org/uniprot/D2HX16 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/9646:PON1 ^@ http://purl.uniprot.org/uniprot/G1LUM0 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit.|||Glycosylated. http://togogenome.org/gene/9646:TFRC ^@ http://purl.uniprot.org/uniprot/G1LBB8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.|||Homodimer; disulfide-linked.|||Melanosome|||Membrane|||Stearoylated. http://togogenome.org/gene/9646:TMEM106B ^@ http://purl.uniprot.org/uniprot/D2HN44 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/9646:FAM126A ^@ http://purl.uniprot.org/uniprot/A0A7N5K9H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Hyccin family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/9646:DIABLO ^@ http://purl.uniprot.org/uniprot/A0A7N5P6F9 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9646:IFITM5 ^@ http://purl.uniprot.org/uniprot/D2I618 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9646:NUDC ^@ http://purl.uniprot.org/uniprot/D2GWI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nudC family.|||Midbody|||spindle http://togogenome.org/gene/9646:DKK2 ^@ http://purl.uniprot.org/uniprot/D2H5H2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/9646:ZWILCH ^@ http://purl.uniprot.org/uniprot/G1L993 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ZWILCH family.|||Component of the RZZ complex.|||Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.|||kinetochore http://togogenome.org/gene/9646:LOC100469041 ^@ http://purl.uniprot.org/uniprot/G1M0N2 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9646:ELF3 ^@ http://purl.uniprot.org/uniprot/D2GZM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9646:EML6 ^@ http://purl.uniprot.org/uniprot/G1LBY5 ^@ Function|||Similarity ^@ Belongs to the WD repeat EMAP family.|||May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. http://togogenome.org/gene/9646:SOD1 ^@ http://purl.uniprot.org/uniprot/G1M910 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Cu-Zn superoxide dismutase family.|||Binds 1 copper ion per subunit.|||Binds 1 zinc ion per subunit.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/9646:CDH6 ^@ http://purl.uniprot.org/uniprot/D2HD82 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:ASPHD2 ^@ http://purl.uniprot.org/uniprot/G1MI89 ^@ Similarity ^@ Belongs to the aspartyl/asparaginyl beta-hydroxylase family. http://togogenome.org/gene/9646:ELOVL1 ^@ http://purl.uniprot.org/uniprot/D2HSR2|||http://purl.uniprot.org/uniprot/G1L499 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ELO family.|||Belongs to the ELO family. ELOVL1 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.|||Endoplasmic reticulum membrane|||Interacts with LASS2, TECR and HSD17B12.|||Membrane|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9646:CCNY ^@ http://purl.uniprot.org/uniprot/G1LVF3 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin Y subfamily. http://togogenome.org/gene/9646:SSTR2 ^@ http://purl.uniprot.org/uniprot/D2HUB6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).|||Membrane|||Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization. http://togogenome.org/gene/9646:EEF1G ^@ http://purl.uniprot.org/uniprot/G1LJN0 ^@ Function|||Subunit ^@ EF-1 is composed of four subunits: alpha, beta, delta, and gamma.|||Probably plays a role in anchoring the complex to other cellular components. http://togogenome.org/gene/9646:ARAP2 ^@ http://purl.uniprot.org/uniprot/G1LFY4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:SLC25A21 ^@ http://purl.uniprot.org/uniprot/G1L847 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9646:NGF ^@ http://purl.uniprot.org/uniprot/D2HS24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NGF-beta family.|||Secreted http://togogenome.org/gene/9646:HTR1D ^@ http://purl.uniprot.org/uniprot/D2HCC1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Homodimer. Heterodimer with HTR1B.|||Membrane http://togogenome.org/gene/9646:HSPA4L ^@ http://purl.uniprot.org/uniprot/D2HIW9 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9646:ATG101 ^@ http://purl.uniprot.org/uniprot/D2HHD9 ^@ Similarity ^@ Belongs to the ATG101 family. http://togogenome.org/gene/9646:SAMD4B ^@ http://purl.uniprot.org/uniprot/G1LPQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMAUG family.|||Cytoplasm http://togogenome.org/gene/9646:CCT7 ^@ http://purl.uniprot.org/uniprot/G1MAN4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm|||Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.|||Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. http://togogenome.org/gene/9646:GSTT2B ^@ http://purl.uniprot.org/uniprot/D2HRC6 ^@ Similarity ^@ Belongs to the GST superfamily. Theta family. http://togogenome.org/gene/9646:TAF1B ^@ http://purl.uniprot.org/uniprot/G1LXU2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRN7/TAF1B family.|||Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.|||nucleolus http://togogenome.org/gene/9646:EXOSC9 ^@ http://purl.uniprot.org/uniprot/G1LHU1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:CRBN ^@ http://purl.uniprot.org/uniprot/A0A7N5KNE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRBN family.|||Nucleus http://togogenome.org/gene/9646:VPS37A ^@ http://purl.uniprot.org/uniprot/D2HN29 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/9646:PHAX ^@ http://purl.uniprot.org/uniprot/D2H8F8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PHAX family.|||Cytoplasm http://togogenome.org/gene/9646:FAM122B ^@ http://purl.uniprot.org/uniprot/A0A7N5K7N9|||http://purl.uniprot.org/uniprot/D2HA97|||http://purl.uniprot.org/uniprot/G1L3D5 ^@ Similarity ^@ Belongs to the FAM122 family. http://togogenome.org/gene/9646:EYA3 ^@ http://purl.uniprot.org/uniprot/A0A7N5KIV5|||http://purl.uniprot.org/uniprot/G1LXK1 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/9646:LOC100475174 ^@ http://purl.uniprot.org/uniprot/D2HVS7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9646:FABP4 ^@ http://purl.uniprot.org/uniprot/G1M7P1 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9646:SH3YL1 ^@ http://purl.uniprot.org/uniprot/A0A7N5PAV4 ^@ Similarity|||Subunit ^@ Belongs to the SH3YL1 family.|||Interacts with SH3D19. http://togogenome.org/gene/9646:MED1 ^@ http://purl.uniprot.org/uniprot/G1LBE5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 1 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/9646:FAM110A ^@ http://purl.uniprot.org/uniprot/D2HSA7 ^@ Similarity ^@ Belongs to the FAM110 family. http://togogenome.org/gene/9646:KIF3C ^@ http://purl.uniprot.org/uniprot/D2GXP2 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9646:RNASE10 ^@ http://purl.uniprot.org/uniprot/D2I2U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pancreatic ribonuclease family.|||Secreted http://togogenome.org/gene/9646:GUCY2F ^@ http://purl.uniprot.org/uniprot/D2HNT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane|||Photoreceptor outer segment membrane http://togogenome.org/gene/9646:EDIL3 ^@ http://purl.uniprot.org/uniprot/G1LDJ9|||http://purl.uniprot.org/uniprot/G1LDK1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:PLK3 ^@ http://purl.uniprot.org/uniprot/G1M6J4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. http://togogenome.org/gene/9646:TXN ^@ http://purl.uniprot.org/uniprot/A0A7N5P2T0 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/9646:MFSD14A ^@ http://purl.uniprot.org/uniprot/D2HFE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/9646:CD164 ^@ http://purl.uniprot.org/uniprot/A0A7N5JER8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD164 family.|||Membrane http://togogenome.org/gene/9646:INHBE ^@ http://purl.uniprot.org/uniprot/D2H382 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/9646:RPS7 ^@ http://purl.uniprot.org/uniprot/D2I2A9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eS7 family.|||centrosome http://togogenome.org/gene/9646:SYNJ1 ^@ http://purl.uniprot.org/uniprot/D2HCG9 ^@ Similarity ^@ Belongs to the synaptojanin family.|||In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family. http://togogenome.org/gene/9646:FAM216B ^@ http://purl.uniprot.org/uniprot/A0A7N5KDP0 ^@ Similarity ^@ Belongs to the FAM216 family. http://togogenome.org/gene/9646:YPEL5 ^@ http://purl.uniprot.org/uniprot/D2HY36 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9646:FFAR1 ^@ http://purl.uniprot.org/uniprot/D2HFR0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9646:PUS7 ^@ http://purl.uniprot.org/uniprot/D2GX88 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruD family. http://togogenome.org/gene/9646:RUSF1 ^@ http://purl.uniprot.org/uniprot/D2HTD0 ^@ Similarity ^@ Belongs to the RUS1 family. http://togogenome.org/gene/9646:SNX33 ^@ http://purl.uniprot.org/uniprot/D2HRK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane http://togogenome.org/gene/9646:MSH2 ^@ http://purl.uniprot.org/uniprot/D2GUB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA mismatch repair MutS family.|||Component of the post-replicative DNA mismatch repair system (MMR).|||Nucleus http://togogenome.org/gene/9646:PIP ^@ http://purl.uniprot.org/uniprot/A0A7N5JEB8 ^@ Similarity|||Subunit ^@ Belongs to the PIP family.|||Monomer. Interacts with AZGP1. http://togogenome.org/gene/9646:DESI1 ^@ http://purl.uniprot.org/uniprot/D2I286 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/9646:CASS4 ^@ http://purl.uniprot.org/uniprot/A0A7N5K146 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAS family.|||focal adhesion http://togogenome.org/gene/9646:RANGRF ^@ http://purl.uniprot.org/uniprot/A0A7N5KN51 ^@ Similarity ^@ Belongs to the MOG1 family. http://togogenome.org/gene/9646:CAMP ^@ http://purl.uniprot.org/uniprot/G1L3J9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cathelicidin family.|||Secreted http://togogenome.org/gene/9646:CTU2 ^@ http://purl.uniprot.org/uniprot/G1MIK8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTU2/NCS2 family.|||Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.|||Cytoplasm|||Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. http://togogenome.org/gene/9646:TCEA2 ^@ http://purl.uniprot.org/uniprot/G1L5E2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family.|||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.|||Nucleus http://togogenome.org/gene/9646:HMGCR ^@ http://purl.uniprot.org/uniprot/D2H687 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMG-CoA reductase family.|||Endoplasmic reticulum membrane|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9646:CD79A ^@ http://purl.uniprot.org/uniprot/G1LCU5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9646:OSBPL11 ^@ http://purl.uniprot.org/uniprot/G1LC26 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9646:ATG12 ^@ http://purl.uniprot.org/uniprot/G1MF83 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATG12 family.|||Forms a conjugate with ATG5.|||Ubiquitin-like protein involved in autophagic vesicle formation. http://togogenome.org/gene/9646:SPNS3 ^@ http://purl.uniprot.org/uniprot/G1M740 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.|||Membrane http://togogenome.org/gene/9646:CLDN8 ^@ http://purl.uniprot.org/uniprot/D2HNZ7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9646:ACSL6 ^@ http://purl.uniprot.org/uniprot/A0A7N5KN80|||http://purl.uniprot.org/uniprot/G1MH10 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.|||Endoplasmic reticulum membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9646:PARN ^@ http://purl.uniprot.org/uniprot/G1LXQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Cytoplasm http://togogenome.org/gene/9646:WDR46 ^@ http://purl.uniprot.org/uniprot/D2GYZ9 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9646:PEX13 ^@ http://purl.uniprot.org/uniprot/G1MIU5 ^@ Similarity ^@ Belongs to the peroxin-13 family. http://togogenome.org/gene/9646:RAP1GDS1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JZ98 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum|||Mitochondrion http://togogenome.org/gene/9646:VPS8 ^@ http://purl.uniprot.org/uniprot/D2H298 ^@ Similarity ^@ Belongs to the VPS8 family. http://togogenome.org/gene/9646:FGG ^@ http://purl.uniprot.org/uniprot/G1MJI1 ^@ Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted http://togogenome.org/gene/9646:CEP63 ^@ http://purl.uniprot.org/uniprot/G1L9R9 ^@ Similarity ^@ Belongs to the CEP63 family. http://togogenome.org/gene/9646:FURIN ^@ http://purl.uniprot.org/uniprot/D2HCZ3 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9646:DDX24 ^@ http://purl.uniprot.org/uniprot/D2HNZ5 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9646:EMC3 ^@ http://purl.uniprot.org/uniprot/D2HRA1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC3 family.|||Component of the ER membrane protein complex (EMC).|||Membrane http://togogenome.org/gene/9646:CACNB3 ^@ http://purl.uniprot.org/uniprot/G1LKV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||Cytoplasm http://togogenome.org/gene/9646:PTDSS1 ^@ http://purl.uniprot.org/uniprot/D2HFX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphatidyl serine synthase family.|||Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:LOC100477293 ^@ http://purl.uniprot.org/uniprot/G1LU63 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9646:HOPX ^@ http://purl.uniprot.org/uniprot/A0A7N5JZV9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:TFCP2 ^@ http://purl.uniprot.org/uniprot/A0A7N5KNU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus http://togogenome.org/gene/9646:HPS5 ^@ http://purl.uniprot.org/uniprot/A0A7N5KL40|||http://purl.uniprot.org/uniprot/G1MHK3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HPS5 family.|||Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.|||May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.|||cytosol http://togogenome.org/gene/9646:PROP1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JX62 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes. http://togogenome.org/gene/9646:YTHDF3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JWZ1 ^@ Function|||Similarity ^@ Belongs to the YTHDF family.|||Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. http://togogenome.org/gene/9646:ATP6V0D2 ^@ http://purl.uniprot.org/uniprot/D2H5C5 ^@ Similarity ^@ Belongs to the V-ATPase V0D/AC39 subunit family. http://togogenome.org/gene/9646:NDUFB11 ^@ http://purl.uniprot.org/uniprot/A0A7N5JB90 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB11 subunit family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9646:MAB21L2 ^@ http://purl.uniprot.org/uniprot/D2GXR3 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9646:WDFY2 ^@ http://purl.uniprot.org/uniprot/G1LZP5 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9646:RIMKLB ^@ http://purl.uniprot.org/uniprot/D2I202 ^@ Similarity ^@ Belongs to the RimK family. http://togogenome.org/gene/9646:EEF1B2 ^@ http://purl.uniprot.org/uniprot/D2HEP4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the EF-1-beta/EF-1-delta family.|||EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.|||EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. http://togogenome.org/gene/9646:LOC100464417 ^@ http://purl.uniprot.org/uniprot/D2HEH6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9646:RPS18 ^@ http://purl.uniprot.org/uniprot/A0A7N5KKJ7|||http://purl.uniprot.org/uniprot/F2X217 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Component of the small ribosomal subunit. http://togogenome.org/gene/9646:RARS1 ^@ http://purl.uniprot.org/uniprot/G1LKK0 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9646:CLEC12A ^@ http://purl.uniprot.org/uniprot/A0A7N5JXK5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9646:SNRPD1 ^@ http://purl.uniprot.org/uniprot/G1L726 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP core protein family.|||Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Component of the minor spliceosome, which splices U12-type introns. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP. Interacts (via C-terminus) with SMN1 (via Tudor domain); the interaction is direct. Interacts with GEMIN2; the interaction is direct. Interacts with SNRPD2; the interaction is direct.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.|||cytosol http://togogenome.org/gene/9646:MNS1 ^@ http://purl.uniprot.org/uniprot/G1L8N3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MNS1 family.|||Nucleus|||cilium axoneme|||flagellum axoneme http://togogenome.org/gene/9646:NPNT ^@ http://purl.uniprot.org/uniprot/A0A7N5JE48|||http://purl.uniprot.org/uniprot/A0A7N5JSP9|||http://purl.uniprot.org/uniprot/G1MGH6 ^@ Caution|||Similarity ^@ Belongs to the nephronectin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:DPEP1 ^@ http://purl.uniprot.org/uniprot/G1L304 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.|||Homodimer; disulfide-linked.|||Membrane http://togogenome.org/gene/9646:GADD45A ^@ http://purl.uniprot.org/uniprot/G1LCY5 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/9646:LOC100463577 ^@ http://purl.uniprot.org/uniprot/G1LRZ1 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:GGACT ^@ http://purl.uniprot.org/uniprot/D2H0A7 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family.|||Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. http://togogenome.org/gene/9646:PRPS1L1 ^@ http://purl.uniprot.org/uniprot/D2H1H9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family.|||Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.|||Homodimer. The active form is probably a hexamer composed of 3 homodimers. http://togogenome.org/gene/9646:EIF2S2 ^@ http://purl.uniprot.org/uniprot/A0A7N5KL16 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/9646:CRYBB3 ^@ http://purl.uniprot.org/uniprot/G1MHV2 ^@ Function|||Similarity ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens. http://togogenome.org/gene/9646:SGK1 ^@ http://purl.uniprot.org/uniprot/G1MC21 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9646:GSS ^@ http://purl.uniprot.org/uniprot/D2H442 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic GSH synthase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/9646:STC1 ^@ http://purl.uniprot.org/uniprot/D2H026 ^@ Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9646:ELOVL3 ^@ http://purl.uniprot.org/uniprot/D2GXV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Membrane http://togogenome.org/gene/9646:ELP3 ^@ http://purl.uniprot.org/uniprot/G1KZT7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ELP3 family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. http://togogenome.org/gene/9646:PLA2G2E ^@ http://purl.uniprot.org/uniprot/G1L8V5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9646:SV2C ^@ http://purl.uniprot.org/uniprot/D2H691 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/9646:LIN28B ^@ http://purl.uniprot.org/uniprot/A0A7N5JGP7 ^@ Similarity ^@ Belongs to the lin-28 family. http://togogenome.org/gene/9646:GRPR ^@ http://purl.uniprot.org/uniprot/D2HDU6|||http://purl.uniprot.org/uniprot/G1LV27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:SCRN2 ^@ http://purl.uniprot.org/uniprot/D2H552 ^@ Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily. http://togogenome.org/gene/9646:RPL18 ^@ http://purl.uniprot.org/uniprot/F2X256 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL18 family.|||Rough endoplasmic reticulum http://togogenome.org/gene/9646:PNPT1 ^@ http://purl.uniprot.org/uniprot/G1LAW7 ^@ Similarity ^@ Belongs to the polyribonucleotide nucleotidyltransferase family. http://togogenome.org/gene/9646:NECAP2 ^@ http://purl.uniprot.org/uniprot/G1L0Q5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NECAP family.|||Involved in endocytosis.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9646:GPR141 ^@ http://purl.uniprot.org/uniprot/G1ML97 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9646:NDST2 ^@ http://purl.uniprot.org/uniprot/D2HEE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/9646:CLDN18 ^@ http://purl.uniprot.org/uniprot/D2HLW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9646:CCR2 ^@ http://purl.uniprot.org/uniprot/G1MMF1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:HADH ^@ http://purl.uniprot.org/uniprot/A0A7N5P6J6 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/9646:LOC100466380 ^@ http://purl.uniprot.org/uniprot/D2GUM3 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. http://togogenome.org/gene/9646:EPHA7 ^@ http://purl.uniprot.org/uniprot/D2HE60 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:GMPR ^@ http://purl.uniprot.org/uniprot/G1LC97 ^@ Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.|||Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.|||Homotetramer. http://togogenome.org/gene/9646:ME2 ^@ http://purl.uniprot.org/uniprot/D2H522 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/9646:RPS8 ^@ http://purl.uniprot.org/uniprot/F2X209 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS8 family. http://togogenome.org/gene/9646:LOC100473443 ^@ http://purl.uniprot.org/uniprot/G1M7K0 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit.|||Membrane http://togogenome.org/gene/9646:UCP3 ^@ http://purl.uniprot.org/uniprot/D2H1E9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9646:LOC100471516 ^@ http://purl.uniprot.org/uniprot/D2HDV1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the globin family.|||Heterotetramer of two alpha chains and two beta chains.|||Involved in oxygen transport from the lung to the various peripheral tissues.|||The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin. http://togogenome.org/gene/9646:RHBDD3 ^@ http://purl.uniprot.org/uniprot/A0A7N5J953|||http://purl.uniprot.org/uniprot/G1LP49 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:GPD1 ^@ http://purl.uniprot.org/uniprot/G1L318 ^@ Similarity ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/9646:STAM ^@ http://purl.uniprot.org/uniprot/G1LVX5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the STAM family.|||Early endosome membrane|||Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. http://togogenome.org/gene/9646:LOC100480804 ^@ http://purl.uniprot.org/uniprot/G1MP63 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||Mitochondrion|||The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/9646:CERT1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JZC6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum|||Golgi apparatus http://togogenome.org/gene/9646:USP14 ^@ http://purl.uniprot.org/uniprot/A0A7N5K764|||http://purl.uniprot.org/uniprot/G1LJG4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the peptidase C19 family. USP14/UBP6 subfamily.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Interacts with TRIM14; this interaction recruits USP14 to cleave ubiquitin chains of CGAS. http://togogenome.org/gene/9646:RCAN1 ^@ http://purl.uniprot.org/uniprot/G1LFA2 ^@ Similarity ^@ Belongs to the RCAN family. http://togogenome.org/gene/9646:BGLAP ^@ http://purl.uniprot.org/uniprot/G1M772 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the osteocalcin/matrix Gla protein family.|||Binds strongly to apatite and calcium.|||Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.|||Secreted http://togogenome.org/gene/9646:CC2D1B ^@ http://purl.uniprot.org/uniprot/G1LRN0 ^@ Similarity ^@ Belongs to the CC2D1 family. http://togogenome.org/gene/9646:GNB1 ^@ http://purl.uniprot.org/uniprot/G1M4Q5 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/9646:CAB39 ^@ http://purl.uniprot.org/uniprot/D2H6U4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mo25 family.|||Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.|||Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. http://togogenome.org/gene/9646:FLI1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JHX5|||http://purl.uniprot.org/uniprot/G1L733 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9646:FBXO48 ^@ http://purl.uniprot.org/uniprot/D2HS17 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2.|||Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1. Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway. Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation. http://togogenome.org/gene/9646:STX11 ^@ http://purl.uniprot.org/uniprot/G1MNL9 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9646:KRT39 ^@ http://purl.uniprot.org/uniprot/D2HR36 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9646:ERG28 ^@ http://purl.uniprot.org/uniprot/D2GZY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG28 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:LOC100463831 ^@ http://purl.uniprot.org/uniprot/A0A7N5JR96 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:SNF8 ^@ http://purl.uniprot.org/uniprot/G1LEM3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SNF8 family.|||Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II). http://togogenome.org/gene/9646:MRPL19 ^@ http://purl.uniprot.org/uniprot/A0A7N5KCN8 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family. http://togogenome.org/gene/9646:LOC100480823 ^@ http://purl.uniprot.org/uniprot/G1MMZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/9646:TMEM45A ^@ http://purl.uniprot.org/uniprot/G1LB66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/9646:CDK2AP2 ^@ http://purl.uniprot.org/uniprot/D2HGQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDK2AP family.|||Nucleus http://togogenome.org/gene/9646:FAM214A ^@ http://purl.uniprot.org/uniprot/G1LLI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATOS family.|||Nucleus http://togogenome.org/gene/9646:IL1R1 ^@ http://purl.uniprot.org/uniprot/G1M3C9 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9646:MRAP2 ^@ http://purl.uniprot.org/uniprot/D2I5L5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRAP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:CDK15 ^@ http://purl.uniprot.org/uniprot/A0A7N5KPN6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9646:KPNA5 ^@ http://purl.uniprot.org/uniprot/G1LGT6 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9646:ADAT2 ^@ http://purl.uniprot.org/uniprot/G1LYS1 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.|||Probably participates in deamination of adenosine-34 to inosine in many tRNAs. http://togogenome.org/gene/9646:LOC100470602 ^@ http://purl.uniprot.org/uniprot/D2HD52 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9646:NUP133 ^@ http://purl.uniprot.org/uniprot/D2HHC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin Nup133 family.|||nuclear pore complex http://togogenome.org/gene/9646:CHMP1A ^@ http://purl.uniprot.org/uniprot/G1L313 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9646:PDE4C ^@ http://purl.uniprot.org/uniprot/A0A7N5JTE4 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9646:NOS3 ^@ http://purl.uniprot.org/uniprot/G1M5X2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NOS family.|||Binds 1 FAD.|||Binds 1 FMN.|||Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. http://togogenome.org/gene/9646:STAMBP ^@ http://purl.uniprot.org/uniprot/G1MG94 ^@ Similarity ^@ Belongs to the peptidase M67C family. http://togogenome.org/gene/9646:PGAM2 ^@ http://purl.uniprot.org/uniprot/D2HNN1 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/9646:PIANP ^@ http://purl.uniprot.org/uniprot/G1M6A4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:TEX10 ^@ http://purl.uniprot.org/uniprot/D2HZ39 ^@ Similarity ^@ Belongs to the IPI1/TEX10 family. http://togogenome.org/gene/9646:CYRIA ^@ http://purl.uniprot.org/uniprot/G1L2J0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CYRI family.|||Interacts with RAC1 (GTP-bound form preferentially).|||Membrane http://togogenome.org/gene/9646:BACE1 ^@ http://purl.uniprot.org/uniprot/G1LPE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Endosome|||Membrane|||Membrane raft|||Recycling endosome|||trans-Golgi network http://togogenome.org/gene/9646:COPS7A ^@ http://purl.uniprot.org/uniprot/D2HJ13 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:CFAP91 ^@ http://purl.uniprot.org/uniprot/G1LKP0 ^@ Similarity ^@ Belongs to the CFAP91 family. http://togogenome.org/gene/9646:RHCE ^@ http://purl.uniprot.org/uniprot/G1LUH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/9646:CSTF1 ^@ http://purl.uniprot.org/uniprot/D2HGJ1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:SENP2 ^@ http://purl.uniprot.org/uniprot/G1MEF8 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/9646:TOR1AIP1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JIJ6|||http://purl.uniprot.org/uniprot/D2HFH3|||http://purl.uniprot.org/uniprot/G1L8D3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TOR1AIP family.|||Membrane http://togogenome.org/gene/9646:IRAK2 ^@ http://purl.uniprot.org/uniprot/A0A7N5K5Y6|||http://purl.uniprot.org/uniprot/G1MC45 ^@ Function|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.|||Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.|||Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. http://togogenome.org/gene/9646:SRP9 ^@ http://purl.uniprot.org/uniprot/D2HVN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP9 family.|||Cytoplasm http://togogenome.org/gene/9646:GOT1L1 ^@ http://purl.uniprot.org/uniprot/D2H699 ^@ Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer. http://togogenome.org/gene/9646:PLD3 ^@ http://purl.uniprot.org/uniprot/D2HMV7 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/9646:VIRMA ^@ http://purl.uniprot.org/uniprot/G1LH02 ^@ Similarity ^@ Belongs to the vir family. http://togogenome.org/gene/9646:C3 ^@ http://purl.uniprot.org/uniprot/G1LL53 ^@ Function|||Subcellular Location Annotation ^@ Acts as a chemoattractant for neutrophils in chronic inflammation.|||C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.|||Secreted http://togogenome.org/gene/9646:PGM2L1 ^@ http://purl.uniprot.org/uniprot/D2H1E5 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/9646:SLCO2B1 ^@ http://purl.uniprot.org/uniprot/G1MFF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:ALAS1 ^@ http://purl.uniprot.org/uniprot/D2HAU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:WDR18 ^@ http://purl.uniprot.org/uniprot/D2HMD2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat IPI3/WDR18 family.|||Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Interacts with NOL9. Component of the PELP1 complex, composed of at least PELP1, TEX10 and WDR18. The complex interacts with pre-60S ribosome particles.|||Cytoplasm|||Dynein axonemal particle|||Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. May play a role during development.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9646:PACC1 ^@ http://purl.uniprot.org/uniprot/A0A7N5K7Z1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the proton-activated chloride channel family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:NFX1 ^@ http://purl.uniprot.org/uniprot/G1LLR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NFX1 family.|||Nucleus http://togogenome.org/gene/9646:EPHA4 ^@ http://purl.uniprot.org/uniprot/D2HRP3 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome|||Membrane http://togogenome.org/gene/9646:HENMT1 ^@ http://purl.uniprot.org/uniprot/G1LCG3 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. HEN1 family. http://togogenome.org/gene/9646:CERS5 ^@ http://purl.uniprot.org/uniprot/D2HJD0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9646:RACK1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JIE3 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily. http://togogenome.org/gene/9646:MPP7 ^@ http://purl.uniprot.org/uniprot/G1LNG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Cell membrane|||adherens junction|||tight junction http://togogenome.org/gene/9646:NTN4 ^@ http://purl.uniprot.org/uniprot/G1L5X5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:THY1 ^@ http://purl.uniprot.org/uniprot/G1LMF3 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9646:EZH2 ^@ http://purl.uniprot.org/uniprot/A0A7N5KNT6|||http://purl.uniprot.org/uniprot/G1L7Y5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:SSH3 ^@ http://purl.uniprot.org/uniprot/A0A7N5KND1|||http://purl.uniprot.org/uniprot/G1L1K5 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. http://togogenome.org/gene/9646:GBP5 ^@ http://purl.uniprot.org/uniprot/G1LS20 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9646:POLR3A ^@ http://purl.uniprot.org/uniprot/G1MHI4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA polymerase beta' chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/9646:MGST1 ^@ http://purl.uniprot.org/uniprot/D2HA64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Membrane http://togogenome.org/gene/9646:POLR3B ^@ http://purl.uniprot.org/uniprot/G1MC66 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/9646:S100A1 ^@ http://purl.uniprot.org/uniprot/G1M0I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the S-100 family.|||Cytoplasm|||Mitochondrion http://togogenome.org/gene/9646:RIBC1 ^@ http://purl.uniprot.org/uniprot/D2HVU9 ^@ Similarity ^@ Belongs to the RIB43A family. http://togogenome.org/gene/9646:TMED2 ^@ http://purl.uniprot.org/uniprot/D2GVZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9646:DUSP27 ^@ http://purl.uniprot.org/uniprot/D2HX66 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9646:TRMT11 ^@ http://purl.uniprot.org/uniprot/A0A7N5P5E2 ^@ Function|||Subunit ^@ Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.|||Interacts with TRMT112. http://togogenome.org/gene/9646:BARX2 ^@ http://purl.uniprot.org/uniprot/D2GUX7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:TRMT2A ^@ http://purl.uniprot.org/uniprot/G1LZ69 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:THNSL2 ^@ http://purl.uniprot.org/uniprot/D2HJ86 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/9646:WNK4 ^@ http://purl.uniprot.org/uniprot/D2HIU9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. http://togogenome.org/gene/9646:KDM4A ^@ http://purl.uniprot.org/uniprot/D2HSQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JHDM3 histone demethylase family.|||Nucleus http://togogenome.org/gene/9646:PTPN6 ^@ http://purl.uniprot.org/uniprot/G1M5D9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.|||Cytoplasm http://togogenome.org/gene/9646:BMPR1A ^@ http://purl.uniprot.org/uniprot/G1LTU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9646:LOC100478197 ^@ http://purl.uniprot.org/uniprot/D2I6G5 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9646:SLC52A2 ^@ http://purl.uniprot.org/uniprot/G1LGP0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the riboflavin transporter family.|||Cell membrane|||Membrane|||Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. http://togogenome.org/gene/9646:PNPLA6 ^@ http://purl.uniprot.org/uniprot/A0A7N5KFC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NTE family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:SMPD1 ^@ http://purl.uniprot.org/uniprot/G1MDB7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acid sphingomyelinase family.|||Binds 2 Zn(2+) ions per subunit.|||Converts sphingomyelin to ceramide.|||Secreted http://togogenome.org/gene/9646:CARM1 ^@ http://purl.uniprot.org/uniprot/G1LX00 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:PTGER2 ^@ http://purl.uniprot.org/uniprot/D2I4Z9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:NCSTN ^@ http://purl.uniprot.org/uniprot/G1M6K2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nicastrin family.|||Membrane http://togogenome.org/gene/9646:GOT2 ^@ http://purl.uniprot.org/uniprot/G1MG53 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/9646:RAB43 ^@ http://purl.uniprot.org/uniprot/D2H7D0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane http://togogenome.org/gene/9646:RNASE13 ^@ http://purl.uniprot.org/uniprot/D2HYC6|||http://purl.uniprot.org/uniprot/G1MP09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pancreatic ribonuclease family.|||Secreted http://togogenome.org/gene/9646:ZDHHC1 ^@ http://purl.uniprot.org/uniprot/G1MG82 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9646:HPS3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JME9|||http://purl.uniprot.org/uniprot/A0A7N5JRL7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.|||Cytoplasm|||Involved in early stages of melanosome biogenesis and maturation. http://togogenome.org/gene/9646:STAC3 ^@ http://purl.uniprot.org/uniprot/D2H379 ^@ Subcellular Location Annotation ^@ sarcolemma http://togogenome.org/gene/9646:SPA17 ^@ http://purl.uniprot.org/uniprot/A0A7N5P1Y9 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates. http://togogenome.org/gene/9646:GJD2 ^@ http://purl.uniprot.org/uniprot/G1LEY5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9646:LOC100482979 ^@ http://purl.uniprot.org/uniprot/G1MIM5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the p22phox family.|||Cell membrane|||Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).|||Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.|||Membrane http://togogenome.org/gene/9646:CTSB ^@ http://purl.uniprot.org/uniprot/D2HMR2 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9646:SLC12A1 ^@ http://purl.uniprot.org/uniprot/D2H739|||http://purl.uniprot.org/uniprot/G1L5A2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9646:BMPR1B ^@ http://purl.uniprot.org/uniprot/D2H1C0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9646:LOC100464665 ^@ http://purl.uniprot.org/uniprot/E5L4Y6 ^@ Function|||Similarity ^@ Belongs to the cytochrome c oxidase subunit 6B.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. http://togogenome.org/gene/9646:PER2 ^@ http://purl.uniprot.org/uniprot/G1M8P6 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9646:BEX3 ^@ http://purl.uniprot.org/uniprot/D2HTN8 ^@ Similarity ^@ Belongs to the BEX family. http://togogenome.org/gene/9646:PARG ^@ http://purl.uniprot.org/uniprot/G1LLS0 ^@ Similarity ^@ Belongs to the poly(ADP-ribose) glycohydrolase family. http://togogenome.org/gene/9646:SLC24A4 ^@ http://purl.uniprot.org/uniprot/G1M592 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/9646:CTLA4 ^@ http://purl.uniprot.org/uniprot/D2HDB8|||http://purl.uniprot.org/uniprot/G1L880 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.|||Membrane http://togogenome.org/gene/9646:RDH5 ^@ http://purl.uniprot.org/uniprot/G1LZD8 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9646:PHKA2 ^@ http://purl.uniprot.org/uniprot/A0A7N5J9G3|||http://purl.uniprot.org/uniprot/A0A7N5JIW5|||http://purl.uniprot.org/uniprot/G1MEG4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.|||Belongs to the phosphorylase b kinase regulatory chain family.|||Cell membrane|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.|||Membrane|||Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. http://togogenome.org/gene/9646:NIPA2 ^@ http://purl.uniprot.org/uniprot/D2I443 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9646:GALNT6 ^@ http://purl.uniprot.org/uniprot/G1L5F2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:GREM2 ^@ http://purl.uniprot.org/uniprot/D2H9I0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9646:HMOX1 ^@ http://purl.uniprot.org/uniprot/G1L3U2 ^@ Similarity ^@ Belongs to the heme oxygenase family. http://togogenome.org/gene/9646:CSRNP3 ^@ http://purl.uniprot.org/uniprot/G1L6Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AXUD1 family.|||Nucleus http://togogenome.org/gene/9646:KCNK2 ^@ http://purl.uniprot.org/uniprot/A0A7N5K3M7|||http://purl.uniprot.org/uniprot/G1MBA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9646:TMEM38B ^@ http://purl.uniprot.org/uniprot/D2HXY1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM38 family.|||Membrane|||Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. http://togogenome.org/gene/9646:TMEM198 ^@ http://purl.uniprot.org/uniprot/D2HQR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM198 family.|||Membrane http://togogenome.org/gene/9646:ASIC2 ^@ http://purl.uniprot.org/uniprot/G1LGP4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:STING1 ^@ http://purl.uniprot.org/uniprot/G1LXK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STING family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Mitochondrion outer membrane|||autophagosome membrane|||perinuclear region http://togogenome.org/gene/9646:ST8SIA3 ^@ http://purl.uniprot.org/uniprot/D2HE31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9646:C6H10orf53 ^@ http://purl.uniprot.org/uniprot/G1LLE1 ^@ Similarity ^@ Belongs to the UPF0728 family. http://togogenome.org/gene/9646:DENR ^@ http://purl.uniprot.org/uniprot/G1M8H4 ^@ Similarity ^@ Belongs to the DENR family. http://togogenome.org/gene/9646:LOC100470415 ^@ http://purl.uniprot.org/uniprot/G1MN92 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/9646:COPE ^@ http://purl.uniprot.org/uniprot/D2GV44 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPE family.|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. http://togogenome.org/gene/9646:IQSEC2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JCS2 ^@ Similarity ^@ Belongs to the BRAG family. http://togogenome.org/gene/9646:RDH11 ^@ http://purl.uniprot.org/uniprot/G1LN89 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9646:RPS5 ^@ http://purl.uniprot.org/uniprot/F2X205 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS7 family. http://togogenome.org/gene/9646:XPO1 ^@ http://purl.uniprot.org/uniprot/D2HZX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm http://togogenome.org/gene/9646:ARL14 ^@ http://purl.uniprot.org/uniprot/D2HVY5 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9646:RPRD1A ^@ http://purl.uniprot.org/uniprot/D2HQD4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the RNA polymerase II complex.|||Belongs to the UPF0400 (RTT103) family.|||Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.|||Nucleus http://togogenome.org/gene/9646:NRDE2 ^@ http://purl.uniprot.org/uniprot/G1L4X0 ^@ Similarity ^@ Belongs to the NRDE2 family. http://togogenome.org/gene/9646:TMEM14A ^@ http://purl.uniprot.org/uniprot/G1L6G5 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/9646:MMD ^@ http://purl.uniprot.org/uniprot/G1M848 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9646:DCP1A ^@ http://purl.uniprot.org/uniprot/G1LMP9 ^@ Similarity ^@ Belongs to the DCP1 family. http://togogenome.org/gene/9646:PHTF2 ^@ http://purl.uniprot.org/uniprot/A0A7N5P348 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:MITF ^@ http://purl.uniprot.org/uniprot/A0A7N5KJH7|||http://purl.uniprot.org/uniprot/G1MFG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/9646:DOLPP1 ^@ http://purl.uniprot.org/uniprot/G1MBT8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dolichyldiphosphatase family.|||Endoplasmic reticulum membrane|||Membrane|||Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate. http://togogenome.org/gene/9646:SAMHD1 ^@ http://purl.uniprot.org/uniprot/G1M1D6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAMHD1 family.|||Chromosome http://togogenome.org/gene/9646:PPIC ^@ http://purl.uniprot.org/uniprot/A0A7N5P0X8 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9646:CES3 ^@ http://purl.uniprot.org/uniprot/G1MFP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Secreted http://togogenome.org/gene/9646:ESRRG ^@ http://purl.uniprot.org/uniprot/A0A7N5JV70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/9646:LOC100472074 ^@ http://purl.uniprot.org/uniprot/D2GVD1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space|||Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. http://togogenome.org/gene/9646:PLPP2 ^@ http://purl.uniprot.org/uniprot/G1L749 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9646:NIPAL3 ^@ http://purl.uniprot.org/uniprot/G1LU09|||http://purl.uniprot.org/uniprot/G1LU11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9646:RPL7L1 ^@ http://purl.uniprot.org/uniprot/G1M2B5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/9646:MTG2 ^@ http://purl.uniprot.org/uniprot/A0A7N5P188 ^@ Similarity ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. http://togogenome.org/gene/9646:ADGRG7 ^@ http://purl.uniprot.org/uniprot/D2H5V7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:LOC100483708 ^@ http://purl.uniprot.org/uniprot/A0A7N5JXS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9646:METTL4 ^@ http://purl.uniprot.org/uniprot/D2HU11 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/9646:PDGFRA ^@ http://purl.uniprot.org/uniprot/G1MJ75 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.|||Membrane|||Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.|||Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. http://togogenome.org/gene/9646:PRDX5 ^@ http://purl.uniprot.org/uniprot/G1MHY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxiredoxin family. Prx5 subfamily.|||Peroxisome matrix|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. http://togogenome.org/gene/9646:PDRG1 ^@ http://purl.uniprot.org/uniprot/G1M4S0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.|||Cytoplasm|||May play a role in chaperone-mediated protein folding. http://togogenome.org/gene/9646:LOC100464745 ^@ http://purl.uniprot.org/uniprot/A0A7N5KPZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TOR1AIP family.|||Membrane http://togogenome.org/gene/9646:NRM ^@ http://purl.uniprot.org/uniprot/A0A7N5KMV9|||http://purl.uniprot.org/uniprot/G1M3J2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nurim family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/9646:PDCD11 ^@ http://purl.uniprot.org/uniprot/G1MHX3 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9646:COG2 ^@ http://purl.uniprot.org/uniprot/G1LSZ7 ^@ Similarity ^@ Belongs to the COG2 family. http://togogenome.org/gene/9646:SSRP1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KJQ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SSRP1 family.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Nucleus http://togogenome.org/gene/9646:PACSIN1 ^@ http://purl.uniprot.org/uniprot/G1L2H1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PACSIN family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||cytosol|||ruffle membrane|||synaptosome http://togogenome.org/gene/9646:LOC100476606 ^@ http://purl.uniprot.org/uniprot/G1M9T3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:TM4SF19 ^@ http://purl.uniprot.org/uniprot/D2H4Y5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9646:CCT3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JMS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9646:SNX6 ^@ http://purl.uniprot.org/uniprot/A0A7N5JG04 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9646:TSPAN1 ^@ http://purl.uniprot.org/uniprot/G1M5E5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9646:LOC100484229 ^@ http://purl.uniprot.org/uniprot/G1MK09 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:KIF11 ^@ http://purl.uniprot.org/uniprot/G1M6D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.|||spindle pole http://togogenome.org/gene/9646:PCSK1 ^@ http://purl.uniprot.org/uniprot/D2HUX9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S8 family.|||Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.|||Vesicle|||secretory vesicle http://togogenome.org/gene/9646:RPLP0 ^@ http://purl.uniprot.org/uniprot/F2X229 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL10 family.|||Ribosomal protein P0 is the functional equivalent of E.coli protein L10. http://togogenome.org/gene/9646:PRPF18 ^@ http://purl.uniprot.org/uniprot/G1M4R8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP18 family.|||Nucleus speckle http://togogenome.org/gene/9646:TXLNG ^@ http://purl.uniprot.org/uniprot/D2HDU3 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/9646:SLC17A9 ^@ http://purl.uniprot.org/uniprot/G1MG20|||http://purl.uniprot.org/uniprot/G1MG22 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:TSC22D3 ^@ http://purl.uniprot.org/uniprot/A0A7N5KJC8 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/9646:FAM102A ^@ http://purl.uniprot.org/uniprot/G1M9M1 ^@ Similarity ^@ Belongs to the EEIG family. http://togogenome.org/gene/9646:ACTA2 ^@ http://purl.uniprot.org/uniprot/D2GZ42 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9646:MINPP1 ^@ http://purl.uniprot.org/uniprot/D2GZ31 ^@ Similarity ^@ Belongs to the histidine acid phosphatase family. MINPP1 subfamily. http://togogenome.org/gene/9646:FAM20B ^@ http://purl.uniprot.org/uniprot/D2H3L4 ^@ Similarity ^@ Belongs to the FAM20 family. http://togogenome.org/gene/9646:THBS4 ^@ http://purl.uniprot.org/uniprot/G1MB47 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:ARF5 ^@ http://purl.uniprot.org/uniprot/G1LDA2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/9646:MRPS31 ^@ http://purl.uniprot.org/uniprot/G1LZ09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS31 family.|||Mitochondrion http://togogenome.org/gene/9646:DEFB132 ^@ http://purl.uniprot.org/uniprot/G1LXQ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9646:LOC100468258 ^@ http://purl.uniprot.org/uniprot/G1MNW6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:TP53INP1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JY93|||http://purl.uniprot.org/uniprot/D2HVB6 ^@ Subcellular Location Annotation ^@ PML body|||autophagosome|||cytosol http://togogenome.org/gene/9646:CCND2 ^@ http://purl.uniprot.org/uniprot/D2HEK1 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9646:QARS1 ^@ http://purl.uniprot.org/uniprot/D2HEW0 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9646:MED7 ^@ http://purl.uniprot.org/uniprot/D2GUH8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 7 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9646:TAGLN3 ^@ http://purl.uniprot.org/uniprot/D2H6H8 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/9646:LOC100464796 ^@ http://purl.uniprot.org/uniprot/G1MMC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:LCNL1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JJA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/9646:LOC100478526 ^@ http://purl.uniprot.org/uniprot/D2I472 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:PDC ^@ http://purl.uniprot.org/uniprot/G1MAK0 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9646:ECHDC2 ^@ http://purl.uniprot.org/uniprot/G1LS80 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9646:TRAPPC1 ^@ http://purl.uniprot.org/uniprot/D2HGD9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/9646:CRYAB ^@ http://purl.uniprot.org/uniprot/D2HG87 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small heat shock protein (HSP20) family.|||Contributes to the transparency and refractive index of the lens. Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.|||Cytoplasm|||Heteromer composed of three CRYAA and one CRYAB subunits. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. Can also form homodimers and homotetramers (dimers of dimers) which serve as the building blocks of homooligomers (By similarity). Within homooligomers, the zinc-binding motif is created from residues of 3 different molecules. His-100 and Glu-102 from one molecule are ligands of the zinc ion, and His-107 and His-154 residues from additional molecules complete the site with tetrahedral coordination geometry (By similarity). Part of a complex required for lens intermediate filament formation composed of BFSP1, BFSP2 and CRYAA.|||Nucleus http://togogenome.org/gene/9646:ENOPH1 ^@ http://purl.uniprot.org/uniprot/G1LEU0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.|||Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Monomer.|||Nucleus http://togogenome.org/gene/9646:LOC100479137 ^@ http://purl.uniprot.org/uniprot/G1ML07 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:MFN2 ^@ http://purl.uniprot.org/uniprot/G1LU66 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9646:USP37 ^@ http://purl.uniprot.org/uniprot/G1L8C8 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9646:CLCN4 ^@ http://purl.uniprot.org/uniprot/D2H0T9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Membrane http://togogenome.org/gene/9646:GPI ^@ http://purl.uniprot.org/uniprot/D2HRQ7 ^@ Similarity ^@ Belongs to the GPI family. http://togogenome.org/gene/9646:LOC100472977 ^@ http://purl.uniprot.org/uniprot/G1MNZ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:IL1RN ^@ http://purl.uniprot.org/uniprot/G1LW10 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.|||Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9646:YME1L1 ^@ http://purl.uniprot.org/uniprot/G1L4Y5 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/9646:DZIP1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JX32|||http://purl.uniprot.org/uniprot/G1LUU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DZIP C2H2-type zinc-finger protein family.|||cilium basal body http://togogenome.org/gene/9646:MTERF3 ^@ http://purl.uniprot.org/uniprot/D2HFX7 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/9646:FZD6 ^@ http://purl.uniprot.org/uniprot/D2I6J3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:TARS2 ^@ http://purl.uniprot.org/uniprot/G1L463 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9646:PPARD ^@ http://purl.uniprot.org/uniprot/A0A7N5JAK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9646:SMAD4 ^@ http://purl.uniprot.org/uniprot/D2H520 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:SV2B ^@ http://purl.uniprot.org/uniprot/G1MBR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/9646:FGF7 ^@ http://purl.uniprot.org/uniprot/D2H730 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9646:PLN ^@ http://purl.uniprot.org/uniprot/D2H9K8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholamban family.|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/9646:SNRPD2 ^@ http://purl.uniprot.org/uniprot/G1L1U0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.|||cytosol http://togogenome.org/gene/9646:TAGLN ^@ http://purl.uniprot.org/uniprot/D2HC73 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/9646:SHBG ^@ http://purl.uniprot.org/uniprot/D2HPW8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:FGR ^@ http://purl.uniprot.org/uniprot/D2GWJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane http://togogenome.org/gene/9646:ELOVL2 ^@ http://purl.uniprot.org/uniprot/G1L7F2 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL2 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9646:PLIN5 ^@ http://purl.uniprot.org/uniprot/G1L579 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/9646:SURF4 ^@ http://purl.uniprot.org/uniprot/A0A7N5JKZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SURF4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:HAL ^@ http://purl.uniprot.org/uniprot/G1L5Q5 ^@ Similarity ^@ Belongs to the PAL/histidase family. http://togogenome.org/gene/9646:DBNDD2 ^@ http://purl.uniprot.org/uniprot/G1LC78 ^@ Similarity ^@ Belongs to the dysbindin family. http://togogenome.org/gene/9646:CPB2 ^@ http://purl.uniprot.org/uniprot/G1M3G8 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9646:LOC100465341 ^@ http://purl.uniprot.org/uniprot/D2HI20 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:LOC100467486 ^@ http://purl.uniprot.org/uniprot/G1LMC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/9646:PERP ^@ http://purl.uniprot.org/uniprot/D2H0U4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/9646:B2M ^@ http://purl.uniprot.org/uniprot/A0A7N5K2L4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-2-microglobulin family.|||Secreted http://togogenome.org/gene/9646:THAP1 ^@ http://purl.uniprot.org/uniprot/D2H973 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the THAP1 family.|||DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.|||Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.|||nucleoplasm http://togogenome.org/gene/9646:SNRPD3 ^@ http://purl.uniprot.org/uniprot/G1M5R9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.|||cytosol http://togogenome.org/gene/9646:ECRG4 ^@ http://purl.uniprot.org/uniprot/A0A7N5KQR6 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the augurin family.|||Cytoplasm|||Membrane|||Secreted http://togogenome.org/gene/9646:TJP1 ^@ http://purl.uniprot.org/uniprot/A0A7N5K6U4|||http://purl.uniprot.org/uniprot/G1L8X7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9646:LOC100468438 ^@ http://purl.uniprot.org/uniprot/G1MJX0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:RPL34 ^@ http://purl.uniprot.org/uniprot/D2H5G7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/9646:OPN1SW ^@ http://purl.uniprot.org/uniprot/D2GWS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane|||Photoreceptor inner segment|||photoreceptor outer segment http://togogenome.org/gene/9646:JAGN1 ^@ http://purl.uniprot.org/uniprot/D2HRA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the jagunal family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:SLC49A3 ^@ http://purl.uniprot.org/uniprot/G1MEA6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:FUZ ^@ http://purl.uniprot.org/uniprot/G1M551 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fuzzy family.|||cytoskeleton http://togogenome.org/gene/9646:LOC100474410 ^@ http://purl.uniprot.org/uniprot/G1MKM1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9646:POLR2D ^@ http://purl.uniprot.org/uniprot/D2HY08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/9646:UBE2K ^@ http://purl.uniprot.org/uniprot/G1L8Q8 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9646:BCAT1 ^@ http://purl.uniprot.org/uniprot/A0A7N5K284|||http://purl.uniprot.org/uniprot/G1LMC4 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9646:DHRS7B ^@ http://purl.uniprot.org/uniprot/A0A7N5JQI5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9646:PSKH2 ^@ http://purl.uniprot.org/uniprot/D2H5C4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9646:DLGAP4 ^@ http://purl.uniprot.org/uniprot/A0A7N5KLA4|||http://purl.uniprot.org/uniprot/D2H463 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/9646:PLRG1 ^@ http://purl.uniprot.org/uniprot/G1MJH6 ^@ Similarity ^@ Belongs to the WD repeat PRL1/PRL2 family. http://togogenome.org/gene/9646:CROT ^@ http://purl.uniprot.org/uniprot/D2GY16 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/9646:LOC100479323 ^@ http://purl.uniprot.org/uniprot/A0A7N5JSG3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:MCOLN3 ^@ http://purl.uniprot.org/uniprot/D2HBY7 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Membrane http://togogenome.org/gene/9646:A4GNT ^@ http://purl.uniprot.org/uniprot/D2HLW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 32 family.|||Golgi apparatus membrane http://togogenome.org/gene/9646:RNASEH1 ^@ http://purl.uniprot.org/uniprot/G1MJF2 ^@ Function|||Similarity ^@ Belongs to the RNase H family.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. http://togogenome.org/gene/9646:TRAPPC9 ^@ http://purl.uniprot.org/uniprot/A0A7N5KMS3 ^@ Similarity ^@ Belongs to the NIBP family. http://togogenome.org/gene/9646:TRH ^@ http://purl.uniprot.org/uniprot/D2HGM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRH family.|||Secreted http://togogenome.org/gene/9646:TMEM17 ^@ http://purl.uniprot.org/uniprot/D2HI02 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:H1-2 ^@ http://purl.uniprot.org/uniprot/D2I084 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9646:LOC100475579 ^@ http://purl.uniprot.org/uniprot/D2HP59 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:MST1R ^@ http://purl.uniprot.org/uniprot/D2HET6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:GABRB2 ^@ http://purl.uniprot.org/uniprot/D2GUJ8|||http://purl.uniprot.org/uniprot/G1LGA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9646:RPS28 ^@ http://purl.uniprot.org/uniprot/D2HZS4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/9646:POPDC3 ^@ http://purl.uniprot.org/uniprot/D2H5S0 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/9646:AK6 ^@ http://purl.uniprot.org/uniprot/G1L925 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.|||Cajal body|||Monomer and homodimer. Interacts with COIL (via C-terminus).|||nucleoplasm http://togogenome.org/gene/9646:FMO5 ^@ http://purl.uniprot.org/uniprot/D2I2Z8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9646:RPL36AL ^@ http://purl.uniprot.org/uniprot/D2HIE2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/9646:MAGOH ^@ http://purl.uniprot.org/uniprot/D2H2F2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mago nashi family.|||Nucleus http://togogenome.org/gene/9646:LOC100474749 ^@ http://purl.uniprot.org/uniprot/G1M0A3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.|||Membrane http://togogenome.org/gene/9646:THAP10 ^@ http://purl.uniprot.org/uniprot/D2HJ75 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the THAP1 family.|||DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.|||Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.|||nucleoplasm http://togogenome.org/gene/9646:TXNIP ^@ http://purl.uniprot.org/uniprot/D2HQ53 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9646:TREX2 ^@ http://purl.uniprot.org/uniprot/G1LQQ9 ^@ Similarity ^@ Belongs to the exonuclease superfamily. TREX family. http://togogenome.org/gene/9646:SF3A3 ^@ http://purl.uniprot.org/uniprot/G1L393 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3A3 family.|||Nucleus http://togogenome.org/gene/9646:AMPD1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JLH8 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/9646:LOC100483480 ^@ http://purl.uniprot.org/uniprot/D3YBZ7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/9646:SGMS2 ^@ http://purl.uniprot.org/uniprot/D2H5H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/9646:EIF2S1 ^@ http://purl.uniprot.org/uniprot/D2HRG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-2-alpha family.|||Stress granule http://togogenome.org/gene/9646:LOC100472142 ^@ http://purl.uniprot.org/uniprot/G1LZZ8 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:CDKN1A ^@ http://purl.uniprot.org/uniprot/A0A7N5JGR5 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/9646:EIF1B ^@ http://purl.uniprot.org/uniprot/A0A7N5JY87 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/9646:WTAP ^@ http://purl.uniprot.org/uniprot/G1MAD4 ^@ Similarity ^@ Belongs to the fl(2)d family. http://togogenome.org/gene/9646:LSM1 ^@ http://purl.uniprot.org/uniprot/G1LXB6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Cytoplasm|||Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.|||P-body|||Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. http://togogenome.org/gene/9646:ANXA6 ^@ http://purl.uniprot.org/uniprot/A0A7N5KQ14|||http://purl.uniprot.org/uniprot/G1LNP3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.|||Melanosome http://togogenome.org/gene/9646:SNCB ^@ http://purl.uniprot.org/uniprot/A0A7N5JGK6 ^@ Similarity ^@ Belongs to the synuclein family. http://togogenome.org/gene/9646:KIF27 ^@ http://purl.uniprot.org/uniprot/D2H0N9 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9646:GALNT3 ^@ http://purl.uniprot.org/uniprot/D2HW57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:SDR16C5 ^@ http://purl.uniprot.org/uniprot/A0A7N5KMK4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9646:LHFPL1 ^@ http://purl.uniprot.org/uniprot/D2HIC3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:COPB1 ^@ http://purl.uniprot.org/uniprot/G1L6M9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ COPI-coated vesicle membrane|||Cytoplasm|||Endoplasmic reticulum-Golgi intermediate compartment|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/9646:SLC6A12 ^@ http://purl.uniprot.org/uniprot/D2GYE2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Basolateral cell membrane|||Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily.|||Cell membrane|||Interacts with LIN7C.|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9646:FPR2 ^@ http://purl.uniprot.org/uniprot/D2HYN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Membrane http://togogenome.org/gene/9646:TSPYL4 ^@ http://purl.uniprot.org/uniprot/G1MN34 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9646:LOC100475228 ^@ http://purl.uniprot.org/uniprot/D2HEK7 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:PKM ^@ http://purl.uniprot.org/uniprot/G1LHU6 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/9646:CLDN3 ^@ http://purl.uniprot.org/uniprot/D2HMA0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the claudin family.|||Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9646:RARB ^@ http://purl.uniprot.org/uniprot/G1L1L8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9646:GFRA3 ^@ http://purl.uniprot.org/uniprot/G1MDL5 ^@ Similarity ^@ Belongs to the GDNFR family. http://togogenome.org/gene/9646:IL23A ^@ http://purl.uniprot.org/uniprot/D2H355 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-6 superfamily.|||Secreted http://togogenome.org/gene/9646:ARCN1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JYC4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/9646:RGS12 ^@ http://purl.uniprot.org/uniprot/D2H4H4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:MRPL58 ^@ http://purl.uniprot.org/uniprot/D2HD32 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prokaryotic/mitochondrial release factor family. Mitochondrion-specific ribosomal protein mL62 subfamily.|||Component of the mitochondrial 39S ribosomal subunit.|||Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (By similarity).|||In contrast to other members of the family, lacks the regions that come into close contact with the mRNA in the ribosomal A-site and determine the STOP codon specificity, explaining the loss of codon specificity for translation release factor activity.|||Mitochondrion http://togogenome.org/gene/9646:TMEM106A ^@ http://purl.uniprot.org/uniprot/D2I4D7 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/9646:TMEM88B ^@ http://purl.uniprot.org/uniprot/D2HPN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM88 family.|||Membrane http://togogenome.org/gene/9646:ROPN1L ^@ http://purl.uniprot.org/uniprot/G1LAP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ropporin family.|||flagellum http://togogenome.org/gene/9646:LOC100468796 ^@ http://purl.uniprot.org/uniprot/A0A7N5KAC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9646:LOC100482539 ^@ http://purl.uniprot.org/uniprot/D2HZU2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9646:SLC46A3 ^@ http://purl.uniprot.org/uniprot/G1LQT5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:ATP5F1A ^@ http://purl.uniprot.org/uniprot/G1M1T5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/9646:POLR2H ^@ http://purl.uniprot.org/uniprot/D2H2A3 ^@ Similarity ^@ Belongs to the eukaryotic RPB8 RNA polymerase subunit family. http://togogenome.org/gene/9646:SMUG1 ^@ http://purl.uniprot.org/uniprot/G1L1H7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.|||Nucleus http://togogenome.org/gene/9646:GALK2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JLA0|||http://purl.uniprot.org/uniprot/G1L3S2 ^@ Similarity ^@ Belongs to the GHMP kinase family. GalK subfamily. http://togogenome.org/gene/9646:CHST4 ^@ http://purl.uniprot.org/uniprot/G1L6G3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/9646:LOC100475101 ^@ http://purl.uniprot.org/uniprot/D2I1N0 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9646:EARS2 ^@ http://purl.uniprot.org/uniprot/G1M702 ^@ Function|||Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). http://togogenome.org/gene/9646:MFSD5 ^@ http://purl.uniprot.org/uniprot/D2HLP8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Cell membrane|||Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.|||Membrane http://togogenome.org/gene/9646:SMDT1 ^@ http://purl.uniprot.org/uniprot/D2HVL2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMDT1/EMRE family.|||Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.|||Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9646:LOC100467553 ^@ http://purl.uniprot.org/uniprot/A0A7N5JHJ4 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/9646:GABPA ^@ http://purl.uniprot.org/uniprot/G1MFL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9646:GALM ^@ http://purl.uniprot.org/uniprot/D2HNQ0 ^@ Similarity ^@ Belongs to the aldose epimerase family. http://togogenome.org/gene/9646:PPFIA1 ^@ http://purl.uniprot.org/uniprot/A0A7N5K9Y5|||http://purl.uniprot.org/uniprot/A0A7N5KH37 ^@ Similarity ^@ Belongs to the liprin family. Liprin-alpha subfamily. http://togogenome.org/gene/9646:HBP1 ^@ http://purl.uniprot.org/uniprot/G1M4G4 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4. http://togogenome.org/gene/9646:ODF2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JSH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ODF2 family.|||centrosome http://togogenome.org/gene/9646:SLC35A3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JYT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:MTNR1A ^@ http://purl.uniprot.org/uniprot/G1LEM8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.|||Membrane http://togogenome.org/gene/9646:LAMTOR4 ^@ http://purl.uniprot.org/uniprot/A0A7N5JRW2|||http://purl.uniprot.org/uniprot/G1M9M5 ^@ Similarity ^@ Belongs to the LAMTOR4 family. http://togogenome.org/gene/9646:TNFSF13B ^@ http://purl.uniprot.org/uniprot/D2H2R1 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9646:CCDC181 ^@ http://purl.uniprot.org/uniprot/D2H9T2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC181 family.|||Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.|||cytoskeleton http://togogenome.org/gene/9646:GMFG ^@ http://purl.uniprot.org/uniprot/G1LPR7 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. GMF subfamily. http://togogenome.org/gene/9646:NUDT12 ^@ http://purl.uniprot.org/uniprot/D2HL84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Nudix hydrolase family. NudC subfamily.|||Cytoplasmic granule|||Peroxisome http://togogenome.org/gene/9646:LYAR ^@ http://purl.uniprot.org/uniprot/D2HLR9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:LOC100480842 ^@ http://purl.uniprot.org/uniprot/G1MFC0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9646:DPM2 ^@ http://purl.uniprot.org/uniprot/G1M9J2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPM2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum membrane|||Membrane|||Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. http://togogenome.org/gene/9646:CXCL8 ^@ http://purl.uniprot.org/uniprot/A0A7N5JZA1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Homodimer.|||Secreted http://togogenome.org/gene/9646:DCLK2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JM59|||http://purl.uniprot.org/uniprot/D2I3C6 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Autophosphorylated.|||Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.|||Binds to and stabilizes microtubules. Interacts with MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK9/JNK2, PPP1R9B/NEURABIN-2 and actin.|||Protein kinase with a significantly reduced Ca(2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity).|||The doublecortin domains are involved in the colocalization with microtubules.|||cytoskeleton http://togogenome.org/gene/9646:CNR2 ^@ http://purl.uniprot.org/uniprot/G1MPF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:SLC44A4 ^@ http://purl.uniprot.org/uniprot/G1M305 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/9646:ADD1 ^@ http://purl.uniprot.org/uniprot/D2H4G8|||http://purl.uniprot.org/uniprot/G1M7G5 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/9646:TSPAN9 ^@ http://purl.uniprot.org/uniprot/G1LEE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9646:HESX1 ^@ http://purl.uniprot.org/uniprot/A0A7N5P3Q6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ANF homeobox family.|||Nucleus http://togogenome.org/gene/9646:CPNE8 ^@ http://purl.uniprot.org/uniprot/G1LWN0 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9646:GPATCH11 ^@ http://purl.uniprot.org/uniprot/G1MGQ2 ^@ Similarity ^@ Belongs to the GPATCH11 family. http://togogenome.org/gene/9646:MC4R ^@ http://purl.uniprot.org/uniprot/D2HQE7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). http://togogenome.org/gene/9646:TRIM36 ^@ http://purl.uniprot.org/uniprot/A0A7N5P0X7 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9646:LOC100475194 ^@ http://purl.uniprot.org/uniprot/G1MNG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:ADIPOR2 ^@ http://purl.uniprot.org/uniprot/D2GYD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9646:LOC100470732 ^@ http://purl.uniprot.org/uniprot/A0A7N5JMN3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:GATC ^@ http://purl.uniprot.org/uniprot/G1M3T4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/9646:ATP5F1B ^@ http://purl.uniprot.org/uniprot/D2H363 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/9646:ESD ^@ http://purl.uniprot.org/uniprot/A0A7N5JJH1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the esterase D family.|||Cytoplasmic vesicle|||Serine hydrolase involved in the detoxification of formaldehyde. http://togogenome.org/gene/9646:MMS19 ^@ http://purl.uniprot.org/uniprot/D2H5K8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MET18/MMS19 family.|||Component of the CIA complex.|||Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.|||Nucleus|||spindle http://togogenome.org/gene/9646:PROK1 ^@ http://purl.uniprot.org/uniprot/G1LYC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AVIT (prokineticin) family.|||Secreted http://togogenome.org/gene/9646:DYNLT1 ^@ http://purl.uniprot.org/uniprot/G1LSC2 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/9646:LOC100482725 ^@ http://purl.uniprot.org/uniprot/D2GVN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lambda interferon family.|||Secreted http://togogenome.org/gene/9646:LSM14B ^@ http://purl.uniprot.org/uniprot/A0A7N5JZ05|||http://purl.uniprot.org/uniprot/G1M488 ^@ Similarity ^@ Belongs to the LSM14 family. http://togogenome.org/gene/9646:LSM14A ^@ http://purl.uniprot.org/uniprot/A0A7N5P8L1|||http://purl.uniprot.org/uniprot/G1MF04 ^@ Similarity ^@ Belongs to the LSM14 family. http://togogenome.org/gene/9646:KIF21A ^@ http://purl.uniprot.org/uniprot/G1M2Y6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9646:TSPAN15 ^@ http://purl.uniprot.org/uniprot/D2GXH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9646:CHMP7 ^@ http://purl.uniprot.org/uniprot/D2H033 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9646:CERS6 ^@ http://purl.uniprot.org/uniprot/A0A7N5KBY6|||http://purl.uniprot.org/uniprot/G1LWK5 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9646:SLIT2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JW75|||http://purl.uniprot.org/uniprot/G1LIJ7|||http://purl.uniprot.org/uniprot/G1LIL3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9646:ARL3 ^@ http://purl.uniprot.org/uniprot/G1MHI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||centrosome http://togogenome.org/gene/9646:RCAN3 ^@ http://purl.uniprot.org/uniprot/D2GWE0 ^@ Similarity ^@ Belongs to the RCAN family. http://togogenome.org/gene/9646:LOC100467091 ^@ http://purl.uniprot.org/uniprot/G1MJL7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:FUT7 ^@ http://purl.uniprot.org/uniprot/G1M4A1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane http://togogenome.org/gene/9646:FOXK1 ^@ http://purl.uniprot.org/uniprot/D2H492 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:LOC100474580 ^@ http://purl.uniprot.org/uniprot/G1MIL3 ^@ Function|||Similarity ^@ Belongs to the TYW1 family.|||Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis. http://togogenome.org/gene/9646:SCN7A ^@ http://purl.uniprot.org/uniprot/G1L3G6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel (TC 1.A.1.10) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.|||Membrane http://togogenome.org/gene/9646:RPS27 ^@ http://purl.uniprot.org/uniprot/F2X226 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9646:CTTNBP2 ^@ http://purl.uniprot.org/uniprot/G1L2X2 ^@ Subcellular Location Annotation ^@ cell cortex|||dendritic spine http://togogenome.org/gene/9646:VPS11 ^@ http://purl.uniprot.org/uniprot/A0A7N5JNH1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS11 family.|||Cytoplasmic vesicle|||Early endosome|||Late endosome membrane|||Lysosome membrane|||Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.|||autophagosome|||clathrin-coated vesicle http://togogenome.org/gene/9646:AKAP5 ^@ http://purl.uniprot.org/uniprot/D2GYI6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:GASK1A ^@ http://purl.uniprot.org/uniprot/G1M157 ^@ Similarity ^@ Belongs to the GASK family. http://togogenome.org/gene/9646:PSMD5 ^@ http://purl.uniprot.org/uniprot/D2H311 ^@ Similarity ^@ Belongs to the proteasome subunit S5B/HSM3 family. http://togogenome.org/gene/9646:CRAT ^@ http://purl.uniprot.org/uniprot/A0A7N5KBU2|||http://purl.uniprot.org/uniprot/G1MBW9 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/9646:LOC100466374 ^@ http://purl.uniprot.org/uniprot/A0A7N5P7E5 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9646:DCPS ^@ http://purl.uniprot.org/uniprot/D2HV04 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HIT family.|||Cytoplasm|||Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1. http://togogenome.org/gene/9646:YTHDC1 ^@ http://purl.uniprot.org/uniprot/G1LGJ3 ^@ Function|||Similarity ^@ Belongs to the YTHDF family.|||Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. http://togogenome.org/gene/9646:TAF13 ^@ http://purl.uniprot.org/uniprot/A0A7N5P754 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:NPC1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KGZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the patched family.|||Membrane http://togogenome.org/gene/9646:TSPAN12 ^@ http://purl.uniprot.org/uniprot/G1LH97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9646:NEDD8 ^@ http://purl.uniprot.org/uniprot/G1MCQ9 ^@ Similarity ^@ Belongs to the ubiquitin family. http://togogenome.org/gene/9646:LOC100481707 ^@ http://purl.uniprot.org/uniprot/G1LXX3 ^@ Function|||Similarity ^@ Belongs to the pellino family.|||E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. http://togogenome.org/gene/9646:SUPT16H ^@ http://purl.uniprot.org/uniprot/G1LIN2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M24 family. SPT16 subfamily.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Component of the FACT complex.|||Nucleus http://togogenome.org/gene/9646:ATP6V1G3 ^@ http://purl.uniprot.org/uniprot/D2GZP8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9646:LOC100470779 ^@ http://purl.uniprot.org/uniprot/G1M6W8 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9646:FLNC ^@ http://purl.uniprot.org/uniprot/A0A7N5KKU8|||http://purl.uniprot.org/uniprot/G1LEN3 ^@ Similarity ^@ Belongs to the filamin family. http://togogenome.org/gene/9646:GINS4 ^@ http://purl.uniprot.org/uniprot/D2H9P8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GINS4/SLD5 family.|||Chromosome|||Nucleus http://togogenome.org/gene/9646:SSBP1 ^@ http://purl.uniprot.org/uniprot/G1M9E9 ^@ Subcellular Location Annotation ^@ mitochondrion nucleoid http://togogenome.org/gene/9646:SLC50A1 ^@ http://purl.uniprot.org/uniprot/G1LXW3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SWEET sugar transporter family.|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates sugar transport across membranes.|||Membrane http://togogenome.org/gene/9646:MVB12A ^@ http://purl.uniprot.org/uniprot/G1LVI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MVB12 family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9646:C10H16orf91 ^@ http://purl.uniprot.org/uniprot/G1LMX0 ^@ Similarity ^@ Belongs to the UQCC4 family. http://togogenome.org/gene/9646:USP44 ^@ http://purl.uniprot.org/uniprot/D2HBJ8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C19 family. USP44 subfamily.|||Cytoplasm|||Dephosphorylated by CTDP1.|||Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Promotes also the deubiquitination of histone H2A and H2B. Recruited to RNF8/RNF168-ubiquitinated chromatin surrounding double stranded breaks (DSBs), promotes hydrolysis of such ubiquitin conjugates, thus negatively regulating protein recruitment to damaged chromatin (By similarity). Participates in nucleotide excision repair (NER) pathway by deubiquitinating DDB2 to prevent its premature degradation so it can remain on damaged chromatin (By similarity). Promotes FOXP3 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability and increased regulatory T-cell lineage stability. Plays also a positive role in innate immune response to DNA viruses by deubiquitinating STING1, selectively removing its 'Lys-48'-linked polyubiquitin chains and stabilizing it (By similarity).|||Interacts with the N-CoR components TBL1X and TBL1XR1.|||Nucleus|||Ubiquitinated; undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination and is degraded by the proteasome. http://togogenome.org/gene/9646:PI4K2B ^@ http://purl.uniprot.org/uniprot/D2I456 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.|||Membrane http://togogenome.org/gene/9646:ITK ^@ http://purl.uniprot.org/uniprot/G1LHK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane http://togogenome.org/gene/9646:TMEM9B ^@ http://purl.uniprot.org/uniprot/A0A7N5JT80|||http://purl.uniprot.org/uniprot/G1LBR7 ^@ Similarity ^@ Belongs to the TMEM9 family. http://togogenome.org/gene/9646:LOC100469647 ^@ http://purl.uniprot.org/uniprot/D2I7Q0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:LOC100475425 ^@ http://purl.uniprot.org/uniprot/A0A7N5JH76 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9646:ENO2 ^@ http://purl.uniprot.org/uniprot/D2HJ02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/9646:CD68 ^@ http://purl.uniprot.org/uniprot/D2HPW6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9646:SPR ^@ http://purl.uniprot.org/uniprot/D2H0C8 ^@ Similarity ^@ Belongs to the sepiapterin reductase family. http://togogenome.org/gene/9646:TMEM35A ^@ http://purl.uniprot.org/uniprot/D2I0B8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Membrane http://togogenome.org/gene/9646:MOV10 ^@ http://purl.uniprot.org/uniprot/D2H8X0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.|||P-body http://togogenome.org/gene/9646:RPL13A ^@ http://purl.uniprot.org/uniprot/F2X250 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/9646:EIF2B4 ^@ http://purl.uniprot.org/uniprot/G1L421|||http://purl.uniprot.org/uniprot/G1L431 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/9646:CDK8 ^@ http://purl.uniprot.org/uniprot/D2HP84 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9646:PLPP1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JEA8|||http://purl.uniprot.org/uniprot/G1M5Q1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9646:USB1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KFE5|||http://purl.uniprot.org/uniprot/G1MFP5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 2H phosphoesterase superfamily. USB1 family.|||Nucleus|||Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. http://togogenome.org/gene/9646:TLR3 ^@ http://purl.uniprot.org/uniprot/D2HM22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9646:MDM4 ^@ http://purl.uniprot.org/uniprot/G1L2U1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM2/MDM4 family.|||Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.|||Nucleus http://togogenome.org/gene/9646:PANX3 ^@ http://purl.uniprot.org/uniprot/D2HNJ7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Structural component of the gap junctions and the hemichannels.|||gap junction http://togogenome.org/gene/9646:VPS28 ^@ http://purl.uniprot.org/uniprot/G1LGG4 ^@ Function|||Similarity ^@ Belongs to the VPS28 family.|||Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. http://togogenome.org/gene/9646:ACTG1 ^@ http://purl.uniprot.org/uniprot/D2I7P0 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9646:COPS4 ^@ http://purl.uniprot.org/uniprot/G1LEI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN4 family.|||Nucleus|||Vesicle|||synaptic vesicle http://togogenome.org/gene/9646:MIP ^@ http://purl.uniprot.org/uniprot/D2H358 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:XKR9 ^@ http://purl.uniprot.org/uniprot/D2H9L8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9646:DLL4 ^@ http://purl.uniprot.org/uniprot/G1MEL4 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/9646:BCL2A1 ^@ http://purl.uniprot.org/uniprot/G1LIJ8 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9646:DPM1 ^@ http://purl.uniprot.org/uniprot/G1M3Z7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum|||Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex. http://togogenome.org/gene/9646:LOC100466373 ^@ http://purl.uniprot.org/uniprot/D2I4V2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9646:INTS7 ^@ http://purl.uniprot.org/uniprot/G1L352 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 7 family.|||Nucleus http://togogenome.org/gene/9646:PLAA ^@ http://purl.uniprot.org/uniprot/D2I1P6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat PLAP family.|||Cytoplasm http://togogenome.org/gene/9646:BCAN ^@ http://purl.uniprot.org/uniprot/G1M8L0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aggrecan/versican proteoglycan family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9646:UXS1 ^@ http://purl.uniprot.org/uniprot/D2GWY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9646:CDH19 ^@ http://purl.uniprot.org/uniprot/D2HIK2 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:LOC100482014 ^@ http://purl.uniprot.org/uniprot/D2HLL2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/9646:CCDC58 ^@ http://purl.uniprot.org/uniprot/A0A7N5KD84 ^@ Similarity ^@ Belongs to the MIX23 family. http://togogenome.org/gene/9646:FAM174A ^@ http://purl.uniprot.org/uniprot/D2HAA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM174 family.|||Membrane http://togogenome.org/gene/9646:UVSSA ^@ http://purl.uniprot.org/uniprot/A0A7N5JRC2|||http://purl.uniprot.org/uniprot/G1MES7 ^@ Similarity ^@ Belongs to the UVSSA family. http://togogenome.org/gene/9646:LOC100468508 ^@ http://purl.uniprot.org/uniprot/G1MNW7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:C3H5orf22 ^@ http://purl.uniprot.org/uniprot/G1LHL1 ^@ Similarity ^@ Belongs to the UPF0489 family. http://togogenome.org/gene/9646:POLH ^@ http://purl.uniprot.org/uniprot/D2GZB3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:GABARAPL2 ^@ http://purl.uniprot.org/uniprot/G1LFR7 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9646:ARPC3 ^@ http://purl.uniprot.org/uniprot/G1M5V7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC3 family.|||Component of the Arp2/3 complex.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton http://togogenome.org/gene/9646:LOC109488326 ^@ http://purl.uniprot.org/uniprot/G1LG84 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9646:RGS2 ^@ http://purl.uniprot.org/uniprot/D2HM07 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||nucleolus http://togogenome.org/gene/9646:NUP58 ^@ http://purl.uniprot.org/uniprot/A0A7N5K8R2|||http://purl.uniprot.org/uniprot/G1M6P8 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/9646:TMEM170A ^@ http://purl.uniprot.org/uniprot/D2HY24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM170 family.|||Membrane http://togogenome.org/gene/9646:MON1B ^@ http://purl.uniprot.org/uniprot/G1M884 ^@ Function|||Similarity ^@ Belongs to the MON1/SAND family.|||Plays an important role in membrane trafficking through the secretory apparatus. http://togogenome.org/gene/9646:LOC100473467 ^@ http://purl.uniprot.org/uniprot/D2HU15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:JPH3 ^@ http://purl.uniprot.org/uniprot/G1MIV4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the junctophilin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.|||Membrane http://togogenome.org/gene/9646:RPS26 ^@ http://purl.uniprot.org/uniprot/D3YBZ6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS26 family. http://togogenome.org/gene/9646:CAMK1G ^@ http://purl.uniprot.org/uniprot/D2HIK0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9646:RNF182 ^@ http://purl.uniprot.org/uniprot/D2H788 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway. Also plays a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA.|||Interacts with ATP6V0C.|||Membrane|||The RING-type zinc finger domain is required for E3 ligase activity. http://togogenome.org/gene/9646:RTCB ^@ http://purl.uniprot.org/uniprot/D2HHB0 ^@ Cofactor|||Similarity ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9646:XPO5 ^@ http://purl.uniprot.org/uniprot/A0A7N5K2C4|||http://purl.uniprot.org/uniprot/G1M0I0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm http://togogenome.org/gene/9646:TMEM8B ^@ http://purl.uniprot.org/uniprot/G1LTQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:LOC100483224 ^@ http://purl.uniprot.org/uniprot/A0A7N5P996 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-5A synthase family.|||Cytoplasm http://togogenome.org/gene/9646:EDC4 ^@ http://purl.uniprot.org/uniprot/G1MGS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat EDC4 family.|||P-body http://togogenome.org/gene/9646:LOC100477677 ^@ http://purl.uniprot.org/uniprot/D2HY23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/9646:GRIA2 ^@ http://purl.uniprot.org/uniprot/A0A7N5P606|||http://purl.uniprot.org/uniprot/D2HBM3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9646:BTC ^@ http://purl.uniprot.org/uniprot/G1M715 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:PUS7L ^@ http://purl.uniprot.org/uniprot/A0A7N5JWJ6 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruD family. http://togogenome.org/gene/9646:GDE1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JK04|||http://purl.uniprot.org/uniprot/D2HYW9 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9646:MED18 ^@ http://purl.uniprot.org/uniprot/D2GWK5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 18 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9646:PPIB ^@ http://purl.uniprot.org/uniprot/D2GYR4 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9646:LOC100484571 ^@ http://purl.uniprot.org/uniprot/D2I6W9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:NSDHL ^@ http://purl.uniprot.org/uniprot/G1L0G9 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9646:PIGC ^@ http://purl.uniprot.org/uniprot/D2H5H3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGC family.|||Membrane http://togogenome.org/gene/9646:USP51 ^@ http://purl.uniprot.org/uniprot/D2I7W5|||http://purl.uniprot.org/uniprot/G1MLV1 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9646:YWHAZ ^@ http://purl.uniprot.org/uniprot/A0A7N5KS25 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9646:POMK ^@ http://purl.uniprot.org/uniprot/D2H969 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif. http://togogenome.org/gene/9646:FDFT1 ^@ http://purl.uniprot.org/uniprot/D2HMR1 ^@ Function|||Similarity ^@ Belongs to the phytoene/squalene synthase family.|||Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. http://togogenome.org/gene/9646:GRIA3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JXS9|||http://purl.uniprot.org/uniprot/G1M8F0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9646:RAP2C ^@ http://purl.uniprot.org/uniprot/D2HKT8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Palmitoylated.|||Recycling endosome membrane|||Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. http://togogenome.org/gene/9646:PAQR4 ^@ http://purl.uniprot.org/uniprot/D2I6Z2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9646:DHRS9 ^@ http://purl.uniprot.org/uniprot/D2H4D4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9646:EVA1B ^@ http://purl.uniprot.org/uniprot/D2HRM7 ^@ Similarity ^@ Belongs to the EVA1 family. http://togogenome.org/gene/9646:FRAS1 ^@ http://purl.uniprot.org/uniprot/G1LG13 ^@ Similarity ^@ Belongs to the FRAS1 family. http://togogenome.org/gene/9646:WNT7A ^@ http://purl.uniprot.org/uniprot/A0A7N5K0U2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9646:PRKAA1 ^@ http://purl.uniprot.org/uniprot/A0A7N5P827|||http://purl.uniprot.org/uniprot/D2HJX7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. http://togogenome.org/gene/9646:SLC15A2 ^@ http://purl.uniprot.org/uniprot/D2HWU1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Interacts (via extracellular domain region) with trypsin.|||Membrane http://togogenome.org/gene/9646:RAD17 ^@ http://purl.uniprot.org/uniprot/G1L956 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad17/RAD24 family.|||Nucleus http://togogenome.org/gene/9646:SIX1 ^@ http://purl.uniprot.org/uniprot/D2GVS4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:LOC100470170 ^@ http://purl.uniprot.org/uniprot/A0A7N5P3N5 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus http://togogenome.org/gene/9646:GAPDH ^@ http://purl.uniprot.org/uniprot/D6BQW4 ^@ Similarity|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/9646:LOC105235968 ^@ http://purl.uniprot.org/uniprot/A0A7N5JNL3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9646:UPP1 ^@ http://purl.uniprot.org/uniprot/G1LDM5 ^@ Similarity ^@ Belongs to the PNP/UDP phosphorylase family. http://togogenome.org/gene/9646:SLC17A2 ^@ http://purl.uniprot.org/uniprot/G1MBR8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:LOC100466302 ^@ http://purl.uniprot.org/uniprot/G1M477 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIIc family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9646:CSF1 ^@ http://purl.uniprot.org/uniprot/G1LEP2 ^@ Function|||Subunit ^@ Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.|||Homodimer or heterodimer; disulfide-linked. Interacts with CSF1R. http://togogenome.org/gene/9646:YIPF7 ^@ http://purl.uniprot.org/uniprot/G1MCC5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:SEMA5A ^@ http://purl.uniprot.org/uniprot/D2H9X1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:DDX31 ^@ http://purl.uniprot.org/uniprot/G1LBU3 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9646:TYK2 ^@ http://purl.uniprot.org/uniprot/D2HGY7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9646:SLC27A2 ^@ http://purl.uniprot.org/uniprot/G1LQK5 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9646:LAMTOR3 ^@ http://purl.uniprot.org/uniprot/G1L2D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR3 family.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/9646:ABHD2 ^@ http://purl.uniprot.org/uniprot/D2HCD9 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/9646:ACYP2 ^@ http://purl.uniprot.org/uniprot/A0A7N5KC83 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/9646:SERP1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KPS6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAMP4 family.|||Endoplasmic reticulum membrane|||May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.|||Membrane http://togogenome.org/gene/9646:ADCY8 ^@ http://purl.uniprot.org/uniprot/D2H7A3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane http://togogenome.org/gene/9646:SH3BP5L ^@ http://purl.uniprot.org/uniprot/D2I5Y9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SH3BP5 family.|||Cytoplasm|||Functions as guanine nucleotide exchange factor (GEF) for RAB11A.|||Interacts with GDP-bound and nucleotide-free forms of RAB11A.|||The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape. http://togogenome.org/gene/9646:UST ^@ http://purl.uniprot.org/uniprot/A0A7N5K928 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 3 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:LOC100473285 ^@ http://purl.uniprot.org/uniprot/D2HLW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM200 family.|||Membrane http://togogenome.org/gene/9646:CDIP1 ^@ http://purl.uniprot.org/uniprot/G1L4Y9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/9646:PFN4 ^@ http://purl.uniprot.org/uniprot/G1L7Q0 ^@ Similarity ^@ Belongs to the profilin family. http://togogenome.org/gene/9646:CDCA7L ^@ http://purl.uniprot.org/uniprot/G1LBH3 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9646:LOC100471709 ^@ http://purl.uniprot.org/uniprot/D2HU41 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:MARCHF4 ^@ http://purl.uniprot.org/uniprot/D2GXF0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:PRPF3 ^@ http://purl.uniprot.org/uniprot/D2HBU4 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). http://togogenome.org/gene/9646:GAPVD1 ^@ http://purl.uniprot.org/uniprot/G1MDX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GAPVD1 family.|||Membrane http://togogenome.org/gene/9646:C14H18orf25 ^@ http://purl.uniprot.org/uniprot/D2H8K0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:PDE6B ^@ http://purl.uniprot.org/uniprot/G1ME74 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9646:AP2M1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KIG7|||http://purl.uniprot.org/uniprot/D2H2A9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cell membrane|||Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.|||coated pit http://togogenome.org/gene/9646:LOC100474594 ^@ http://purl.uniprot.org/uniprot/G1MPC9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:IMMP2L ^@ http://purl.uniprot.org/uniprot/G1LGY4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26 family. IMP2 subfamily.|||Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.|||Heterodimer of 2 subunits, IMMPL1 and IMMPL2.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9646:MB ^@ http://purl.uniprot.org/uniprot/D2HSS2 ^@ Function|||Similarity ^@ Belongs to the globin family.|||Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. http://togogenome.org/gene/9646:LOC100464636 ^@ http://purl.uniprot.org/uniprot/G1L591 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/9646:LOC100484588 ^@ http://purl.uniprot.org/uniprot/A0A7N5K9E4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/9646:RAB27B ^@ http://purl.uniprot.org/uniprot/D2GZT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/9646:EPC1 ^@ http://purl.uniprot.org/uniprot/G1LUZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enhancer of polycomb family.|||Nucleus http://togogenome.org/gene/9646:VPS45 ^@ http://purl.uniprot.org/uniprot/D2HBV3 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9646:SGTA ^@ http://purl.uniprot.org/uniprot/D2HMF6 ^@ Similarity ^@ Belongs to the SGT family. http://togogenome.org/gene/9646:ADCYAP1R1 ^@ http://purl.uniprot.org/uniprot/G1LK41 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:NDUFA2 ^@ http://purl.uniprot.org/uniprot/D2GUN8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA2 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:ST8SIA1 ^@ http://purl.uniprot.org/uniprot/D2H1B3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9646:STAR ^@ http://purl.uniprot.org/uniprot/G1LXA7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ May interact with TSPO.|||Mitochondrion|||Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. http://togogenome.org/gene/9646:UTP3 ^@ http://purl.uniprot.org/uniprot/D2HC96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAS10 family.|||nucleolus http://togogenome.org/gene/9646:CCL20 ^@ http://purl.uniprot.org/uniprot/A0A7N5P516 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9646:LOC100480515 ^@ http://purl.uniprot.org/uniprot/G1M0C1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9646:LOC100483542 ^@ http://purl.uniprot.org/uniprot/D2HWJ0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9646:EHD4 ^@ http://purl.uniprot.org/uniprot/D2GW79 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/9646:PARP9 ^@ http://purl.uniprot.org/uniprot/G1M751 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9646:LOC100466450 ^@ http://purl.uniprot.org/uniprot/G1M215 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9646:PDK2 ^@ http://purl.uniprot.org/uniprot/D2HMX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9646:LOC100468093 ^@ http://purl.uniprot.org/uniprot/D2HI13 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:RPL31 ^@ http://purl.uniprot.org/uniprot/F2X276 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL31 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/9646:CAVIN2 ^@ http://purl.uniprot.org/uniprot/D2H886 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/9646:LOC100477414 ^@ http://purl.uniprot.org/uniprot/D2HRD3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyltransferase family.|||Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.|||Membrane http://togogenome.org/gene/9646:RPL35A ^@ http://purl.uniprot.org/uniprot/F2X282 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL33 family. http://togogenome.org/gene/9646:DCTD ^@ http://purl.uniprot.org/uniprot/A0A7N5JJN9 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/9646:PHTF1 ^@ http://purl.uniprot.org/uniprot/G1L9J0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:ADAMTS4 ^@ http://purl.uniprot.org/uniprot/D2I0T1 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9646:ROPN1 ^@ http://purl.uniprot.org/uniprot/G1LN02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ropporin family.|||flagellum http://togogenome.org/gene/9646:SEPHS1 ^@ http://purl.uniprot.org/uniprot/A0A7N5PA83|||http://purl.uniprot.org/uniprot/D2HSW2 ^@ Function ^@ Synthesizes selenophosphate from selenide and ATP. http://togogenome.org/gene/9646:ARL1 ^@ http://purl.uniprot.org/uniprot/G1MDF4 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9646:BCL2L1 ^@ http://purl.uniprot.org/uniprot/D2H915 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Membrane|||Mitochondrion matrix|||Nucleus membrane|||centrosome|||cytosol|||synaptic vesicle membrane http://togogenome.org/gene/9646:CTNNBL1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JWS0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:HIGD1A ^@ http://purl.uniprot.org/uniprot/G1M168 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/9646:LYZL4 ^@ http://purl.uniprot.org/uniprot/G1L403 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9646:LOC100464807 ^@ http://purl.uniprot.org/uniprot/D2H0Y5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:LOC100464774 ^@ http://purl.uniprot.org/uniprot/G1MNT7 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:GPR87 ^@ http://purl.uniprot.org/uniprot/G1LQH9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:P2RY13 ^@ http://purl.uniprot.org/uniprot/G1ML91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:PSMC3 ^@ http://purl.uniprot.org/uniprot/D2HHK5 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9646:APH1A ^@ http://purl.uniprot.org/uniprot/A0A7N5JKI6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the APH-1 family.|||Component of the gamma-secretase complex.|||Membrane|||Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. http://togogenome.org/gene/9646:PARP2 ^@ http://purl.uniprot.org/uniprot/G1LG33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARTD/PARP family.|||Nucleus http://togogenome.org/gene/9646:DIS3L2 ^@ http://purl.uniprot.org/uniprot/G1MDU8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.|||Belongs to the RNR ribonuclease family. DIS3L2 subfamily.|||Cytoplasm|||P-body|||Specifically recognizes and binds polyuridylated RNAs via 3 RNA-binding regions (named U-zone 1, U-zone 2 and U-zone 3) that form an open funnel on one face of the catalytic domain, allowing RNA to navigate a path to the active site. http://togogenome.org/gene/9646:PAH ^@ http://purl.uniprot.org/uniprot/G1LIM6 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/9646:GJC1 ^@ http://purl.uniprot.org/uniprot/D2HCW4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins. Interacts with CNST.|||Belongs to the connexin family. Gamma-type subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9646:FGF23 ^@ http://purl.uniprot.org/uniprot/D2HEJ9 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9646:FCER1G ^@ http://purl.uniprot.org/uniprot/G1MAD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD3Z/FCER1G family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:LDHB ^@ http://purl.uniprot.org/uniprot/D2I1F1 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/9646:TCTA ^@ http://purl.uniprot.org/uniprot/G1M1M1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TCTA family.|||May be required for cellular fusion during osteoclastogenesis.|||Membrane http://togogenome.org/gene/9646:IRF5 ^@ http://purl.uniprot.org/uniprot/G1LES8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:APC ^@ http://purl.uniprot.org/uniprot/A0A7N5KE23|||http://purl.uniprot.org/uniprot/A0A7N5P5W0|||http://purl.uniprot.org/uniprot/D2HBD2|||http://purl.uniprot.org/uniprot/G1M1X1 ^@ Similarity ^@ Belongs to the adenomatous polyposis coli (APC) family. http://togogenome.org/gene/9646:COG4 ^@ http://purl.uniprot.org/uniprot/D2HFV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG4 family.|||Golgi apparatus membrane http://togogenome.org/gene/9646:LOC100463545 ^@ http://purl.uniprot.org/uniprot/G1L911 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9646:PKNOX1 ^@ http://purl.uniprot.org/uniprot/G1L4U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/9646:HTR5A ^@ http://purl.uniprot.org/uniprot/D2HTZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:STMN3 ^@ http://purl.uniprot.org/uniprot/G1L4E8 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/9646:GTF2E2 ^@ http://purl.uniprot.org/uniprot/D2HFK1 ^@ Function ^@ Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. http://togogenome.org/gene/9646:MAS1 ^@ http://purl.uniprot.org/uniprot/D2HS51 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:MRPL18 ^@ http://purl.uniprot.org/uniprot/G1MA67 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL18 family. http://togogenome.org/gene/9646:FAM13B ^@ http://purl.uniprot.org/uniprot/A0A7N5JDA6|||http://purl.uniprot.org/uniprot/D2HK87 ^@ Similarity ^@ Belongs to the FAM13 family. http://togogenome.org/gene/9646:RAX2 ^@ http://purl.uniprot.org/uniprot/D2HMH9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:VPS25 ^@ http://purl.uniprot.org/uniprot/D2HIU8 ^@ Similarity ^@ Belongs to the VPS25 family. http://togogenome.org/gene/9646:LAPTM4A ^@ http://purl.uniprot.org/uniprot/G1L7S3 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/9646:POSTN ^@ http://purl.uniprot.org/uniprot/A0A7N5JP95|||http://purl.uniprot.org/uniprot/A0A7N5JS45|||http://purl.uniprot.org/uniprot/A0A7N5K6W1|||http://purl.uniprot.org/uniprot/A0A7N5K7W7|||http://purl.uniprot.org/uniprot/G1KZU2 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9646:ERBB4 ^@ http://purl.uniprot.org/uniprot/G1LLD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/9646:STX5 ^@ http://purl.uniprot.org/uniprot/D2HS71 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9646:EHF ^@ http://purl.uniprot.org/uniprot/D2HF02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9646:RIN1 ^@ http://purl.uniprot.org/uniprot/D2H4M3 ^@ Similarity ^@ Belongs to the RIN (Ras interaction/interference) family. http://togogenome.org/gene/9646:LOC100477047 ^@ http://purl.uniprot.org/uniprot/A0A7N5KGG3 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/9646:CYLD ^@ http://purl.uniprot.org/uniprot/A0A7N5JFE2|||http://purl.uniprot.org/uniprot/D2GYQ2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||centrosome|||cilium basal body|||perinuclear region|||spindle http://togogenome.org/gene/9646:GHR ^@ http://purl.uniprot.org/uniprot/Q95JF2 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||Cell membrane|||On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2.|||On growth hormone (GH) binding, forms homodimers and binds JAK2 via a box 1-containing domain. Binding to SOCS3 inhibits JAK2 activation, binding to CIS and SOCS2 inhibits STAT5 activation.|||On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization (By similarity).|||Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity).|||Secreted|||The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.|||The box 1 motif is required for JAK interaction and/or activation.|||The extracellular domain is the ligand-binding domain representing the growth hormone-binding protein (GHBP).|||The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.|||The ubiquitination-dependent endocytosis motif (UbE) is required for recruitment of the ubiquitin conjugation system on to the receptor and for its internalization. http://togogenome.org/gene/9646:CPT2 ^@ http://purl.uniprot.org/uniprot/D2H2F0 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/9646:KCNK1 ^@ http://purl.uniprot.org/uniprot/G1LL10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Cell membrane|||Cytoplasmic vesicle|||Endosome|||Membrane|||Perikaryon|||Recycling endosome|||Synaptic cell membrane|||Vesicle|||dendrite http://togogenome.org/gene/9646:NEURL2 ^@ http://purl.uniprot.org/uniprot/D2HZ10 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:RBM42 ^@ http://purl.uniprot.org/uniprot/D2HFS1 ^@ Similarity ^@ Belongs to the RRM RBM42 family. http://togogenome.org/gene/9646:POLR2A ^@ http://purl.uniprot.org/uniprot/G1MCZ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA polymerase beta' chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/9646:FGD6 ^@ http://purl.uniprot.org/uniprot/G1L649 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9646:EIF2A ^@ http://purl.uniprot.org/uniprot/G1LVF9 ^@ Function|||Similarity ^@ Belongs to the WD repeat EIF2A family.|||Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. http://togogenome.org/gene/9646:MYF5 ^@ http://purl.uniprot.org/uniprot/D2H509 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.|||Nucleus http://togogenome.org/gene/9646:DEFB123 ^@ http://purl.uniprot.org/uniprot/A0A7N5JLX6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9646:PIK3R1 ^@ http://purl.uniprot.org/uniprot/G1L8J9|||http://purl.uniprot.org/uniprot/G1L8K7 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/9646:CXHXorf56 ^@ http://purl.uniprot.org/uniprot/G1KZW0 ^@ Similarity ^@ Belongs to the STEEP1 family. http://togogenome.org/gene/9646:AQP7 ^@ http://purl.uniprot.org/uniprot/G1LLN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:NUDT7 ^@ http://purl.uniprot.org/uniprot/A0A7N5K815 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. PCD1 subfamily. http://togogenome.org/gene/9646:EXOSC2 ^@ http://purl.uniprot.org/uniprot/G1MCS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP4 family.|||Cytoplasm http://togogenome.org/gene/9646:CTBP2 ^@ http://purl.uniprot.org/uniprot/G1LBU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Nucleus http://togogenome.org/gene/9646:TSPAN7 ^@ http://purl.uniprot.org/uniprot/G1LKL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9646:GK2 ^@ http://purl.uniprot.org/uniprot/D2GUG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FGGY kinase family.|||Cytoplasm http://togogenome.org/gene/9646:DUSP6 ^@ http://purl.uniprot.org/uniprot/D2I047 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9646:LOC100468151 ^@ http://purl.uniprot.org/uniprot/G1MPM0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9646:LOC100473112 ^@ http://purl.uniprot.org/uniprot/D2HAL8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:ASIC1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JD63|||http://purl.uniprot.org/uniprot/A0A7N5KI57 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:PSMD2 ^@ http://purl.uniprot.org/uniprot/G1MFJ8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S2 family.|||Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. http://togogenome.org/gene/9646:PADI3 ^@ http://purl.uniprot.org/uniprot/D2HNM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein arginine deiminase family.|||Cytoplasm http://togogenome.org/gene/9646:ADPRH ^@ http://purl.uniprot.org/uniprot/D2H196 ^@ Similarity ^@ Belongs to the ADP-ribosylglycohydrolase family. http://togogenome.org/gene/9646:SEPTIN4 ^@ http://purl.uniprot.org/uniprot/A0A7N5JRK5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9646:SULF1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KLM5|||http://purl.uniprot.org/uniprot/G1LHX9 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Binds 1 Ca(2+) ion per subunit.|||Cell surface|||Endoplasmic reticulum|||Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.|||Golgi stack|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9646:TPM4 ^@ http://purl.uniprot.org/uniprot/D2GUY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9646:SPI1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KKA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9646:SLC9A8 ^@ http://purl.uniprot.org/uniprot/G1M4J2 ^@ Similarity ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. http://togogenome.org/gene/9646:SERPINI2 ^@ http://purl.uniprot.org/uniprot/G1L620 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9646:B3GNT3 ^@ http://purl.uniprot.org/uniprot/A0A7N5P152 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:LOC100476837 ^@ http://purl.uniprot.org/uniprot/D2HQT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9646:RBM46 ^@ http://purl.uniprot.org/uniprot/A0A7N5JYR3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:MYOC ^@ http://purl.uniprot.org/uniprot/G1MEZ2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:ZDHHC24 ^@ http://purl.uniprot.org/uniprot/D2HYA8 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9646:CACNG2 ^@ http://purl.uniprot.org/uniprot/D2GZG6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane|||Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. http://togogenome.org/gene/9646:ZDHHC21 ^@ http://purl.uniprot.org/uniprot/D2H2X8 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9646:LOC100473459 ^@ http://purl.uniprot.org/uniprot/D2HQ18 ^@ Similarity ^@ Belongs to the TACO1 family. http://togogenome.org/gene/9646:CALHM2 ^@ http://purl.uniprot.org/uniprot/D2GXY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9646:NGLY1 ^@ http://purl.uniprot.org/uniprot/D2HUZ7|||http://purl.uniprot.org/uniprot/G1L186 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transglutaminase-like superfamily. PNGase family.|||Cytoplasm|||Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins. http://togogenome.org/gene/9646:FADS2 ^@ http://purl.uniprot.org/uniprot/D2HUF7 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9646:CMC2 ^@ http://purl.uniprot.org/uniprot/D2H7I8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion http://togogenome.org/gene/9646:LIN54 ^@ http://purl.uniprot.org/uniprot/D2GUE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-54 family.|||Nucleus http://togogenome.org/gene/9646:AGO3 ^@ http://purl.uniprot.org/uniprot/G1L1D6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argonaute family. Ago subfamily.|||Interacts with EIF4B, IMP8, PRMT5 and TNRC6B. Interacts with APOBEC3F, APOBEC3G and APOBEC3H.|||P-body|||Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. http://togogenome.org/gene/9646:GOSR2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JMS0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:LOC100476181 ^@ http://purl.uniprot.org/uniprot/D2I6F9 ^@ Similarity ^@ Belongs to the BEX family. http://togogenome.org/gene/9646:HMGA1 ^@ http://purl.uniprot.org/uniprot/G1L2J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGA family.|||Nucleus http://togogenome.org/gene/9646:IFIH1 ^@ http://purl.uniprot.org/uniprot/D2HQW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/9646:ZYG11B ^@ http://purl.uniprot.org/uniprot/A0A7N5JJQ1 ^@ Similarity ^@ Belongs to the zyg-11 family. http://togogenome.org/gene/9646:ATP2A1 ^@ http://purl.uniprot.org/uniprot/G1MAX7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/9646:LOC100470259 ^@ http://purl.uniprot.org/uniprot/G1L0Y9 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Vesicle http://togogenome.org/gene/9646:PALMD ^@ http://purl.uniprot.org/uniprot/G1LRD3 ^@ Similarity ^@ Belongs to the paralemmin family. http://togogenome.org/gene/9646:APH1B ^@ http://purl.uniprot.org/uniprot/D2GYQ5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the APH-1 family.|||Component of the gamma-secretase complex.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. http://togogenome.org/gene/9646:PTGDR ^@ http://purl.uniprot.org/uniprot/D2HV42 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9646:ANXA3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JJR0 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9646:CHRM1 ^@ http://purl.uniprot.org/uniprot/D2HS68 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. http://togogenome.org/gene/9646:SSTR4 ^@ http://purl.uniprot.org/uniprot/D2HSG4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:MRPL40 ^@ http://purl.uniprot.org/uniprot/G1LY56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL40 family.|||Mitochondrion http://togogenome.org/gene/9646:IARS1 ^@ http://purl.uniprot.org/uniprot/G1M4C5 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9646:ARID5B ^@ http://purl.uniprot.org/uniprot/G1LAA8 ^@ Similarity ^@ Belongs to the ARID5B family. http://togogenome.org/gene/9646:POGLUT2 ^@ http://purl.uniprot.org/uniprot/G1MDJ6 ^@ Similarity ^@ Belongs to the KDELC family. http://togogenome.org/gene/9646:VPS13B ^@ http://purl.uniprot.org/uniprot/D2GY40 ^@ Similarity ^@ Belongs to the VPS13 family. http://togogenome.org/gene/9646:RSRP1 ^@ http://purl.uniprot.org/uniprot/D2GWE6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RSRP family.|||Nucleus|||Probably acts as a spliceosomal factor that contributes to spliceosome assembly and regulates the isoform switching of proteins such as PARP6. http://togogenome.org/gene/9646:SSH2 ^@ http://purl.uniprot.org/uniprot/A0A7N5K8H3 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. http://togogenome.org/gene/9646:PGAM1 ^@ http://purl.uniprot.org/uniprot/D2H5L1 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/9646:IMP4 ^@ http://purl.uniprot.org/uniprot/G1L865 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9646:CPA3 ^@ http://purl.uniprot.org/uniprot/D2HWE1 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9646:INIP ^@ http://purl.uniprot.org/uniprot/G1LJU6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SOSS-C family.|||Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).|||Component of the SOSS complex.|||Nucleus http://togogenome.org/gene/9646:TASP1 ^@ http://purl.uniprot.org/uniprot/D2H9J1 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/9646:SMAD9 ^@ http://purl.uniprot.org/uniprot/D2I637|||http://purl.uniprot.org/uniprot/G1M7B8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:MFF ^@ http://purl.uniprot.org/uniprot/A0A7N5K0E9|||http://purl.uniprot.org/uniprot/A0A7N5K5I7|||http://purl.uniprot.org/uniprot/A0A7N5K988|||http://purl.uniprot.org/uniprot/A0A7N5P6F5|||http://purl.uniprot.org/uniprot/A0A7N5P6G1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Tango11 family.|||Membrane|||Mitochondrion outer membrane|||Peroxisome|||Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.|||synaptic vesicle http://togogenome.org/gene/9646:GABARAP ^@ http://purl.uniprot.org/uniprot/G1MDM5 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9646:PCNX1 ^@ http://purl.uniprot.org/uniprot/D2HVR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pecanex family.|||Membrane http://togogenome.org/gene/9646:LOC100474509 ^@ http://purl.uniprot.org/uniprot/A0A7N5K618 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9646:DDI1 ^@ http://purl.uniprot.org/uniprot/G1MLG4 ^@ Similarity ^@ Belongs to the DDI1 family. http://togogenome.org/gene/9646:MRGPRF ^@ http://purl.uniprot.org/uniprot/G1L491 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:FICD ^@ http://purl.uniprot.org/uniprot/A0A7N5JYT5 ^@ Similarity ^@ Belongs to the fic family. http://togogenome.org/gene/9646:FAM110D ^@ http://purl.uniprot.org/uniprot/D2GWG1 ^@ Similarity ^@ Belongs to the FAM110 family. http://togogenome.org/gene/9646:TMCC1 ^@ http://purl.uniprot.org/uniprot/G1LCI4 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/9646:AVIL ^@ http://purl.uniprot.org/uniprot/A0A7N5K0I6 ^@ Similarity ^@ Belongs to the villin/gelsolin family. http://togogenome.org/gene/9646:ITPR1 ^@ http://purl.uniprot.org/uniprot/G1MC67 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the InsP3 receptor family.|||Endoplasmic reticulum membrane|||Homotetramer.|||Membrane|||Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.|||The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. http://togogenome.org/gene/9646:LOC100467204 ^@ http://purl.uniprot.org/uniprot/D2I675 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:TRAM1 ^@ http://purl.uniprot.org/uniprot/G1LID0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAM family.|||Membrane http://togogenome.org/gene/9646:NR1H3 ^@ http://purl.uniprot.org/uniprot/G1LL75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9646:GABRA4 ^@ http://purl.uniprot.org/uniprot/D2H5P3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9646:NUDT5 ^@ http://purl.uniprot.org/uniprot/G1LCQ7 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/9646:TRIM3 ^@ http://purl.uniprot.org/uniprot/D2HR64 ^@ Similarity ^@ Belongs to the TRIM/RBCC family. http://togogenome.org/gene/9646:MRPL49 ^@ http://purl.uniprot.org/uniprot/G1MH32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL49 family.|||Mitochondrion http://togogenome.org/gene/9646:CAMKMT ^@ http://purl.uniprot.org/uniprot/G1LH95 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9646:PSMB1 ^@ http://purl.uniprot.org/uniprot/D2HRT2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:LY6G5C ^@ http://purl.uniprot.org/uniprot/G1LRP9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Forms oligomers.|||May have a role in hematopoietic cell differentiation.|||Secreted http://togogenome.org/gene/9646:LPCAT1 ^@ http://purl.uniprot.org/uniprot/G1LWM6 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9646:GPAT4 ^@ http://purl.uniprot.org/uniprot/G1L7J4 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9646:GPR132 ^@ http://purl.uniprot.org/uniprot/A0A7N5JKX5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:GABARAPL1 ^@ http://purl.uniprot.org/uniprot/A0A7N5K2N8 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9646:NR4A2 ^@ http://purl.uniprot.org/uniprot/A0A7N5KIE1|||http://purl.uniprot.org/uniprot/D2HUI7|||http://purl.uniprot.org/uniprot/G1LTC3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family.|||Cytoplasm|||Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.|||Nucleus http://togogenome.org/gene/9646:XPR1 ^@ http://purl.uniprot.org/uniprot/G1L826 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SYG1 (TC 2.A.94) family.|||Membrane http://togogenome.org/gene/9646:NOSIP ^@ http://purl.uniprot.org/uniprot/D2H7V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOSIP family.|||Nucleus http://togogenome.org/gene/9646:RPL37 ^@ http://purl.uniprot.org/uniprot/G1MA88 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/9646:MAL ^@ http://purl.uniprot.org/uniprot/A0A7N5JLI2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:LOC100478439 ^@ http://purl.uniprot.org/uniprot/G1MKQ6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9646:TNFAIP6 ^@ http://purl.uniprot.org/uniprot/D2HLK3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:SUOX ^@ http://purl.uniprot.org/uniprot/D2H338 ^@ Function|||Subcellular Location Annotation ^@ Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids.|||Mitochondrion intermembrane space http://togogenome.org/gene/9646:ESF1 ^@ http://purl.uniprot.org/uniprot/D2H9J2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESF1 family.|||nucleolus http://togogenome.org/gene/9646:PSKH1 ^@ http://purl.uniprot.org/uniprot/D2H9G2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9646:BMP1 ^@ http://purl.uniprot.org/uniprot/D2H047 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:RHAG ^@ http://purl.uniprot.org/uniprot/A0A7N5JF40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/9646:CDC45 ^@ http://purl.uniprot.org/uniprot/G1LYC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC45 family.|||Nucleus http://togogenome.org/gene/9646:STARD13 ^@ http://purl.uniprot.org/uniprot/A0A7N5K1T9|||http://purl.uniprot.org/uniprot/G1LRW1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:TSEN2 ^@ http://purl.uniprot.org/uniprot/G1LDP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA-intron endonuclease family.|||Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.|||Nucleus http://togogenome.org/gene/9646:CYSLTR2 ^@ http://purl.uniprot.org/uniprot/D2HB76 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9646:SIN3A ^@ http://purl.uniprot.org/uniprot/D2HRJ6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:F7 ^@ http://purl.uniprot.org/uniprot/A0A7N5P4B4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9646:LOC100470335 ^@ http://purl.uniprot.org/uniprot/D2H4W7 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9646:ABITRAM ^@ http://purl.uniprot.org/uniprot/A0A7N5K3K9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABITRAM family.|||growth cone|||lamellipodium http://togogenome.org/gene/9646:RNF146 ^@ http://purl.uniprot.org/uniprot/G1MPB0 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation ^@ E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.|||The WWE domain mediates non-covalent poly(ADP-ribose)-binding.|||Ubiquitinated; autoubiquitinated.|||cytosol http://togogenome.org/gene/9646:VEGFD ^@ http://purl.uniprot.org/uniprot/G1MFE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDGF/VEGF growth factor family.|||Secreted http://togogenome.org/gene/9646:CDK12 ^@ http://purl.uniprot.org/uniprot/D2H526 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.|||Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors (By similarity).|||Interacts with CCNL1 and CCNL2.|||Nucleus|||Nucleus speckle|||Phosphorylation at Thr-894 increases kinase activity. http://togogenome.org/gene/9646:ACOT13 ^@ http://purl.uniprot.org/uniprot/G1LUJ4 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/9646:IRF2BP1 ^@ http://purl.uniprot.org/uniprot/D2I067 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF2BP family.|||Nucleus http://togogenome.org/gene/9646:PPM1G ^@ http://purl.uniprot.org/uniprot/D2GXL3 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9646:NUP35 ^@ http://purl.uniprot.org/uniprot/G1L300 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Nup35 family.|||Functions as a component of the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/9646:CKMT2 ^@ http://purl.uniprot.org/uniprot/D2H3P2 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/9646:DHCR7 ^@ http://purl.uniprot.org/uniprot/G1LLR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Membrane http://togogenome.org/gene/9646:FABP12 ^@ http://purl.uniprot.org/uniprot/G1M7L3 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9646:PGAP2 ^@ http://purl.uniprot.org/uniprot/G1LWV3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PGAP2 family.|||Interacts with PGAP2IP.|||Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface.|||Membrane http://togogenome.org/gene/9646:HAUS3 ^@ http://purl.uniprot.org/uniprot/D2H4G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HAUS3 family.|||spindle http://togogenome.org/gene/9646:MRPS18C ^@ http://purl.uniprot.org/uniprot/D2GUE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Mitochondrion http://togogenome.org/gene/9646:LOC100475627 ^@ http://purl.uniprot.org/uniprot/D2H4U9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIII family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9646:SFXN1 ^@ http://purl.uniprot.org/uniprot/D2HHS9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9646:CASC3 ^@ http://purl.uniprot.org/uniprot/A0A7N5KPL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CASC3 family.|||Nucleus speckle|||dendrite|||perinuclear region http://togogenome.org/gene/9646:PFDN2 ^@ http://purl.uniprot.org/uniprot/G1MAQ8 ^@ Function|||Similarity ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. http://togogenome.org/gene/9646:FARSB ^@ http://purl.uniprot.org/uniprot/G1LHG8 ^@ Similarity ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily. http://togogenome.org/gene/9646:GPR101 ^@ http://purl.uniprot.org/uniprot/D2HD89 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:FOXR2 ^@ http://purl.uniprot.org/uniprot/D2I5Q6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:DIPK1A ^@ http://purl.uniprot.org/uniprot/A0A7N5KI79|||http://purl.uniprot.org/uniprot/A0A7N5KPR9 ^@ Similarity ^@ Belongs to the DIPK family. http://togogenome.org/gene/9646:LOC100477439 ^@ http://purl.uniprot.org/uniprot/D2I5X9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:ATG4C ^@ http://purl.uniprot.org/uniprot/A0A7N5P9H6|||http://purl.uniprot.org/uniprot/D2H7H2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/9646:HLCS ^@ http://purl.uniprot.org/uniprot/A0A7N5JPX5 ^@ Similarity ^@ Belongs to the biotin--protein ligase family. http://togogenome.org/gene/9646:PDK4 ^@ http://purl.uniprot.org/uniprot/G1LUV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9646:CD320 ^@ http://purl.uniprot.org/uniprot/A0A7N5JFR7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:TYW3 ^@ http://purl.uniprot.org/uniprot/D2H5D6 ^@ Function|||Similarity ^@ Belongs to the TYW3 family.|||Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. http://togogenome.org/gene/9646:LBH ^@ http://purl.uniprot.org/uniprot/A0A7N5JJZ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LBH family.|||Cytoplasm|||Nucleus|||Transcriptional activator. http://togogenome.org/gene/9646:LOC100477107 ^@ http://purl.uniprot.org/uniprot/A0A7N5JD01 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:ZDHHC6 ^@ http://purl.uniprot.org/uniprot/D2GX33 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Endoplasmic reticulum membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9646:C8H1orf74 ^@ http://purl.uniprot.org/uniprot/D2HIJ5 ^@ Similarity ^@ Belongs to the UPF0739 family. http://togogenome.org/gene/9646:CEBPG ^@ http://purl.uniprot.org/uniprot/D2I446 ^@ Similarity ^@ Belongs to the bZIP family. C/EBP subfamily. http://togogenome.org/gene/9646:IL1A ^@ http://purl.uniprot.org/uniprot/G1LW58 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-1 family.|||Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage. In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.|||Cytoplasm|||Monomer. Interacts with TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion. Interacts with IL1R1. Interacts with S100A13; this interaction is the first step in the export of IL1A, followed by direct translocation of this complex across the plasma membrane.|||Nucleus|||Secreted http://togogenome.org/gene/9646:CFAP45 ^@ http://purl.uniprot.org/uniprot/A0A7N5KBE7|||http://purl.uniprot.org/uniprot/G1LSF3 ^@ Similarity ^@ Belongs to the CFAP45 family. http://togogenome.org/gene/9646:MGST2 ^@ http://purl.uniprot.org/uniprot/G1LWS4 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:PIGS ^@ http://purl.uniprot.org/uniprot/D2GU34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGS family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:NLK ^@ http://purl.uniprot.org/uniprot/G1LEU7 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9646:FLT1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JSS2 ^@ Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Forms a complex composed of PDGFRL, TNK2 and GRB2. http://togogenome.org/gene/9646:TYRP1 ^@ http://purl.uniprot.org/uniprot/D2HQD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane http://togogenome.org/gene/9646:SELP ^@ http://purl.uniprot.org/uniprot/A0A7N5JJL0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the selectin/LECAM family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:HOMER1 ^@ http://purl.uniprot.org/uniprot/G1MAU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Homer family.|||Cytoplasm|||Postsynaptic density|||Synapse http://togogenome.org/gene/9646:CSAD ^@ http://purl.uniprot.org/uniprot/G1M0J6 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9646:RPL22 ^@ http://purl.uniprot.org/uniprot/F2X262 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL22 family. http://togogenome.org/gene/9646:ORC4 ^@ http://purl.uniprot.org/uniprot/G1M471 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC4 family.|||Component of the origin recognition complex (ORC) that binds origins of replication.|||Nucleus http://togogenome.org/gene/9646:LHX6 ^@ http://purl.uniprot.org/uniprot/G1L1S7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:DTWD2 ^@ http://purl.uniprot.org/uniprot/D2H1R2 ^@ Similarity ^@ Belongs to the TDD superfamily. DTWD2 family. http://togogenome.org/gene/9646:MAP2K1 ^@ http://purl.uniprot.org/uniprot/D2GYT9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9646:CSNK1A1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JCS0|||http://purl.uniprot.org/uniprot/D2H8N0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9646:TLCD3A ^@ http://purl.uniprot.org/uniprot/A0A7N5KH89|||http://purl.uniprot.org/uniprot/A0A7N5KNC6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:LOC100465089 ^@ http://purl.uniprot.org/uniprot/A0A7N5JGS7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:ANO3 ^@ http://purl.uniprot.org/uniprot/A0A7N5KMX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:KDM5C ^@ http://purl.uniprot.org/uniprot/D2HVV1 ^@ Similarity ^@ Belongs to the JARID1 histone demethylase family. http://togogenome.org/gene/9646:AIFM1 ^@ http://purl.uniprot.org/uniprot/A0A7N5P6E4|||http://purl.uniprot.org/uniprot/G1M8T5 ^@ Similarity ^@ Belongs to the FAD-dependent oxidoreductase family. http://togogenome.org/gene/9646:LOC100469295 ^@ http://purl.uniprot.org/uniprot/G1LXW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9646:LPXN ^@ http://purl.uniprot.org/uniprot/A0A7N5KEY6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the paxillin family.|||Cell membrane|||Cytoplasm|||Nucleus|||The LIM domain 3 is critical for focal adhesion targeting and the suppression of paxillin (PXN) tyrosine phosphorylation. The LIM domain 3 alone or both LIM domains 3 and 4 can mediate interaction with AR.|||Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN).|||focal adhesion|||perinuclear region|||podosome http://togogenome.org/gene/9646:LOC100468212 ^@ http://purl.uniprot.org/uniprot/G1MN09 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:TNF ^@ http://purl.uniprot.org/uniprot/D2I4B3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Cell membrane|||Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.|||Homotrimer. Interacts with SPPL2B.|||Membrane|||O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.|||Secreted|||The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.|||The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.|||The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space. http://togogenome.org/gene/9646:LOC100478403 ^@ http://purl.uniprot.org/uniprot/D2HAL5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:KPNA2 ^@ http://purl.uniprot.org/uniprot/D2HQA5 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/9646:FAIM2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JP93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9646:KCNK5 ^@ http://purl.uniprot.org/uniprot/D2HV56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9646:LOC100466952 ^@ http://purl.uniprot.org/uniprot/G1LIW0 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9646:LOC100472940 ^@ http://purl.uniprot.org/uniprot/D2HI70 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:LOC109490896 ^@ http://purl.uniprot.org/uniprot/G1MJV5 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:FAM229B ^@ http://purl.uniprot.org/uniprot/D2H643 ^@ Similarity ^@ Belongs to the FAM229 family. http://togogenome.org/gene/9646:IDH1 ^@ http://purl.uniprot.org/uniprot/D2H8H7 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Homodimer. http://togogenome.org/gene/9646:KCNJ12 ^@ http://purl.uniprot.org/uniprot/D2I1B0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ12 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:MYADM ^@ http://purl.uniprot.org/uniprot/D2HYP7|||http://purl.uniprot.org/uniprot/G1MM34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAL family.|||Membrane http://togogenome.org/gene/9646:ACKR3 ^@ http://purl.uniprot.org/uniprot/D2I542 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:ANXA11 ^@ http://purl.uniprot.org/uniprot/G1M2V2 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9646:NAGA ^@ http://purl.uniprot.org/uniprot/G1LS60 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 27 family.|||Homodimer.|||Lysosome http://togogenome.org/gene/9646:ZNF24 ^@ http://purl.uniprot.org/uniprot/A0A7N5JWJ9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:PLA2G2F ^@ http://purl.uniprot.org/uniprot/A0A7N5P9S1 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9646:NR1H4 ^@ http://purl.uniprot.org/uniprot/A0A7N5KIP8|||http://purl.uniprot.org/uniprot/D2I052 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9646:TBP ^@ http://purl.uniprot.org/uniprot/G1MFA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBP family.|||Nucleus http://togogenome.org/gene/9646:NQO2 ^@ http://purl.uniprot.org/uniprot/G1M738 ^@ Similarity ^@ Belongs to the NAD(P)H dehydrogenase (quinone) family. http://togogenome.org/gene/9646:CCDC25 ^@ http://purl.uniprot.org/uniprot/A0A7N5JQQ3|||http://purl.uniprot.org/uniprot/A0A7N5JUZ0|||http://purl.uniprot.org/uniprot/G1KZU7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CCDC25 family.|||Cell membrane|||Endomembrane system|||Interacts (via cytoplasmic region) with ILK. http://togogenome.org/gene/9646:DDX1 ^@ http://purl.uniprot.org/uniprot/G1L2R9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DDX1 subfamily.|||Cytoplasmic granule|||RNA helicase.|||The helicase domain is involved in the stimulation of RELA transcriptional activity. http://togogenome.org/gene/9646:CLDN14 ^@ http://purl.uniprot.org/uniprot/D2H5U1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9646:ATP5F1C ^@ http://purl.uniprot.org/uniprot/G1LTN3|||http://purl.uniprot.org/uniprot/G1LTN6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase gamma chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. http://togogenome.org/gene/9646:LOC100472222 ^@ http://purl.uniprot.org/uniprot/A0A7N5K287 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:LOC100483213 ^@ http://purl.uniprot.org/uniprot/A0A7N5KRR2 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/9646:ARL11 ^@ http://purl.uniprot.org/uniprot/G1L7N9 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9646:SCAMP1 ^@ http://purl.uniprot.org/uniprot/A0A7N5P947 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/9646:IL2RG ^@ http://purl.uniprot.org/uniprot/A0A7N5P498 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:SASS6 ^@ http://purl.uniprot.org/uniprot/A0A7N5JDB5 ^@ Subcellular Location Annotation ^@ centrosome http://togogenome.org/gene/9646:APOH ^@ http://purl.uniprot.org/uniprot/G1LZF5 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9646:LOC100470966 ^@ http://purl.uniprot.org/uniprot/D2HU37 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:PJVK ^@ http://purl.uniprot.org/uniprot/D2HAF3 ^@ Similarity ^@ Belongs to the gasdermin family. http://togogenome.org/gene/9646:ADGRB3 ^@ http://purl.uniprot.org/uniprot/G1MA43 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:GALNT15 ^@ http://purl.uniprot.org/uniprot/G1LR00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:ENSA ^@ http://purl.uniprot.org/uniprot/G1L3J8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endosulfine family.|||Cytoplasm|||Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. http://togogenome.org/gene/9646:NEFM ^@ http://purl.uniprot.org/uniprot/D2GZ83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intermediate filament family.|||axon http://togogenome.org/gene/9646:CCT5 ^@ http://purl.uniprot.org/uniprot/D2H9W8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9646:LOC100479155 ^@ http://purl.uniprot.org/uniprot/A0A7N5P5T2 ^@ Function|||Similarity ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens. http://togogenome.org/gene/9646:TBRG1 ^@ http://purl.uniprot.org/uniprot/D2HNJ8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:C2H2orf76 ^@ http://purl.uniprot.org/uniprot/D2H746 ^@ Similarity ^@ Belongs to the UPF0538 family. http://togogenome.org/gene/9646:TFPI2 ^@ http://purl.uniprot.org/uniprot/G1MHA9 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9646:MTIF3 ^@ http://purl.uniprot.org/uniprot/D2HWR1 ^@ Similarity ^@ Belongs to the IF-3 family. http://togogenome.org/gene/9646:LOC100483541 ^@ http://purl.uniprot.org/uniprot/G1L1I6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:AP4S1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JMB4 ^@ Similarity ^@ Belongs to the adaptor complexes small subunit family. http://togogenome.org/gene/9646:RNF185 ^@ http://purl.uniprot.org/uniprot/D2H206 ^@ Domain|||Function|||Subcellular Location Annotation ^@ E3 ubiquitin-protein ligase.|||Endoplasmic reticulum membrane|||Mitochondrion membrane|||The RING-type zinc finger domain is responsible for E3 ligase activity. http://togogenome.org/gene/9646:SKIL ^@ http://purl.uniprot.org/uniprot/G1LDF9 ^@ Similarity ^@ Belongs to the SKI family. http://togogenome.org/gene/9646:AP3M1 ^@ http://purl.uniprot.org/uniprot/D2HEE3 ^@ Similarity ^@ Belongs to the adaptor complexes medium subunit family. http://togogenome.org/gene/9646:UBIAD1 ^@ http://purl.uniprot.org/uniprot/D2HKB0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UbiA prenyltransferase family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Interacts with HMGCR and SOAT1.|||Mitochondrion membrane|||Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress. http://togogenome.org/gene/9646:LOC100466240 ^@ http://purl.uniprot.org/uniprot/G1L4K0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9646:IFNAR1 ^@ http://purl.uniprot.org/uniprot/G1M8V8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II cytokine receptor family.|||Cell membrane|||Endosome|||Heterodimer with IFNAR2.|||Late endosome|||Lysosome|||Membrane|||Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway. http://togogenome.org/gene/9646:MAPKAP1 ^@ http://purl.uniprot.org/uniprot/A0A7N5P0L3|||http://purl.uniprot.org/uniprot/D2H3X1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SIN1 family.|||Cytoplasmic vesicle http://togogenome.org/gene/9646:CLDN25 ^@ http://purl.uniprot.org/uniprot/G1MM61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9646:SLCO1C1 ^@ http://purl.uniprot.org/uniprot/G1L2G8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:MPP3 ^@ http://purl.uniprot.org/uniprot/G1MJ15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Cell membrane http://togogenome.org/gene/9646:SLC25A41 ^@ http://purl.uniprot.org/uniprot/D2HY76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9646:TOB2 ^@ http://purl.uniprot.org/uniprot/D2HUX3 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9646:S100A16 ^@ http://purl.uniprot.org/uniprot/D2HJR2 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9646:TPRG1 ^@ http://purl.uniprot.org/uniprot/D2H063 ^@ Similarity ^@ Belongs to the TPRG1 family. http://togogenome.org/gene/9646:DEFB113 ^@ http://purl.uniprot.org/uniprot/G1LQ68 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9646:ALG14 ^@ http://purl.uniprot.org/uniprot/G1ME58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG14 family.|||Endoplasmic reticulum membrane|||Membrane|||Nucleus membrane http://togogenome.org/gene/9646:BYSL ^@ http://purl.uniprot.org/uniprot/D2GZE9 ^@ Similarity ^@ Belongs to the bystin family. http://togogenome.org/gene/9646:LOC100465603 ^@ http://purl.uniprot.org/uniprot/A0A7N5JIH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:BDH1 ^@ http://purl.uniprot.org/uniprot/G1LS82 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9646:SLC12A5 ^@ http://purl.uniprot.org/uniprot/A0A7N5P661 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9646:LOC100468005 ^@ http://purl.uniprot.org/uniprot/A0A7N5KI95 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:ANKRD34B ^@ http://purl.uniprot.org/uniprot/D2H3N9 ^@ Similarity ^@ Belongs to the ANKRD34 family. http://togogenome.org/gene/9646:NCF2 ^@ http://purl.uniprot.org/uniprot/G1L6U4 ^@ Similarity ^@ Belongs to the NCF2/NOXA1 family. http://togogenome.org/gene/9646:HCFC2 ^@ http://purl.uniprot.org/uniprot/A0A7N5KNY3|||http://purl.uniprot.org/uniprot/A0A7N5P6D5|||http://purl.uniprot.org/uniprot/D2H1T2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:TTC26 ^@ http://purl.uniprot.org/uniprot/A0A7N5JGW8 ^@ Similarity ^@ Belongs to the IFT56 family. http://togogenome.org/gene/9646:LIMK2 ^@ http://purl.uniprot.org/uniprot/A0A7N5J9M3|||http://purl.uniprot.org/uniprot/G1LKS6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. http://togogenome.org/gene/9646:GTF2B ^@ http://purl.uniprot.org/uniprot/G1MCK2 ^@ Similarity ^@ Belongs to the TFIIB family. http://togogenome.org/gene/9646:CRYBB2 ^@ http://purl.uniprot.org/uniprot/G1MHW4 ^@ Function|||Similarity ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens. http://togogenome.org/gene/9646:NOP10 ^@ http://purl.uniprot.org/uniprot/D2I545 ^@ Similarity ^@ Belongs to the NOP10 family. http://togogenome.org/gene/9646:LOC100478083 ^@ http://purl.uniprot.org/uniprot/G1MPB4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:PGAP1 ^@ http://purl.uniprot.org/uniprot/D2HDI6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI inositol-deacylase family.|||Endoplasmic reticulum membrane|||Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:MARVELD2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JBK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9646:KIF18B ^@ http://purl.uniprot.org/uniprot/G1MJA3 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9646:MTCH2 ^@ http://purl.uniprot.org/uniprot/D2HHL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9646:LOC100474931 ^@ http://purl.uniprot.org/uniprot/G1LDT9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:TMEM150A ^@ http://purl.uniprot.org/uniprot/G1L673 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:SNRNP200 ^@ http://purl.uniprot.org/uniprot/G1LR17 ^@ Similarity ^@ Belongs to the helicase family. SKI2 subfamily. http://togogenome.org/gene/9646:INA ^@ http://purl.uniprot.org/uniprot/D2GXX6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9646:MS4A1 ^@ http://purl.uniprot.org/uniprot/G1L0L4 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9646:RNF170 ^@ http://purl.uniprot.org/uniprot/G1LED2 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:LPAR6 ^@ http://purl.uniprot.org/uniprot/G1MK04 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:TTI2 ^@ http://purl.uniprot.org/uniprot/G1L7X2 ^@ Similarity ^@ Belongs to the TTI2 family. http://togogenome.org/gene/9646:AMZ1 ^@ http://purl.uniprot.org/uniprot/D2I4M2 ^@ Function|||Similarity ^@ Belongs to the peptidase M54 family.|||Probable zinc metalloprotease. http://togogenome.org/gene/9646:ADAMDEC1 ^@ http://purl.uniprot.org/uniprot/G1L469 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:LOC100483510 ^@ http://purl.uniprot.org/uniprot/G1MM59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCTS1 family.|||Cytoplasm http://togogenome.org/gene/9646:LOC100471307 ^@ http://purl.uniprot.org/uniprot/A0A7N5K185 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/9646:TSSC4 ^@ http://purl.uniprot.org/uniprot/D2HDT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TSSC4 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:PA2G4 ^@ http://purl.uniprot.org/uniprot/D2H342 ^@ Similarity ^@ Belongs to the peptidase M24 family. http://togogenome.org/gene/9646:TMEM254 ^@ http://purl.uniprot.org/uniprot/A0A7N5KAT8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:LOC100475860 ^@ http://purl.uniprot.org/uniprot/G1LBC0 ^@ Similarity ^@ Belongs to the PRORSD1 family. http://togogenome.org/gene/9646:APEX2 ^@ http://purl.uniprot.org/uniprot/D2I7U1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Cytoplasm|||Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.|||Mitochondrion|||Nucleus|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/9646:SERPINB2 ^@ http://purl.uniprot.org/uniprot/G1M9G4 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9646:STX10 ^@ http://purl.uniprot.org/uniprot/G1M1W6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Golgi apparatus membrane http://togogenome.org/gene/9646:LOC100470039 ^@ http://purl.uniprot.org/uniprot/G1MJN3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:NOL6 ^@ http://purl.uniprot.org/uniprot/G1LLI8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NRAP family.|||Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.|||nucleolus http://togogenome.org/gene/9646:LOC100480630 ^@ http://purl.uniprot.org/uniprot/G1MAG9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit C family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm|||Phosphorylated. Phosphorylation is enhanced upon serum stimulation. http://togogenome.org/gene/9646:CDK6 ^@ http://purl.uniprot.org/uniprot/A0A7N5KAU0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9646:AKR1B1 ^@ http://purl.uniprot.org/uniprot/G1MCH6 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9646:KIF5A ^@ http://purl.uniprot.org/uniprot/A0A7N5JT79|||http://purl.uniprot.org/uniprot/G1LES0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9646:IFNK ^@ http://purl.uniprot.org/uniprot/D2HTQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9646:EXOC3 ^@ http://purl.uniprot.org/uniprot/D2HVI3 ^@ Similarity ^@ Belongs to the SEC6 family. http://togogenome.org/gene/9646:AP4B1 ^@ http://purl.uniprot.org/uniprot/D2H8V9 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/9646:BTD ^@ http://purl.uniprot.org/uniprot/A0A7N5JZW3|||http://purl.uniprot.org/uniprot/A0A7N5K8Q0 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. http://togogenome.org/gene/9646:MED6 ^@ http://purl.uniprot.org/uniprot/A0A7N5JSA2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 6 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9646:ALDH8A1 ^@ http://purl.uniprot.org/uniprot/D2H0U5 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9646:RECQL5 ^@ http://purl.uniprot.org/uniprot/G1LSQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RecQ subfamily.|||Nucleus http://togogenome.org/gene/9646:AP1G1 ^@ http://purl.uniprot.org/uniprot/D2HFW7 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/9646:SRP14 ^@ http://purl.uniprot.org/uniprot/G1MFR9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SRP14 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.|||Cytoplasm|||Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. http://togogenome.org/gene/9646:RIOK2 ^@ http://purl.uniprot.org/uniprot/G1M7U1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/9646:LIPT2 ^@ http://purl.uniprot.org/uniprot/D2H1E3 ^@ Similarity ^@ Belongs to the LipB family. http://togogenome.org/gene/9646:ITIH1 ^@ http://purl.uniprot.org/uniprot/G1LP37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/9646:SERINC1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KA10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9646:LOC109488528 ^@ http://purl.uniprot.org/uniprot/G1MN32 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:G6PD ^@ http://purl.uniprot.org/uniprot/A0A7N5KEA1|||http://purl.uniprot.org/uniprot/A0A7N5P323 ^@ Function|||Similarity ^@ Belongs to the glucose-6-phosphate dehydrogenase family.|||Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. http://togogenome.org/gene/9646:RELL1 ^@ http://purl.uniprot.org/uniprot/G1LXP7 ^@ Similarity ^@ Belongs to the RELT family. http://togogenome.org/gene/9646:PRKRIP1 ^@ http://purl.uniprot.org/uniprot/G1MAB8 ^@ Similarity ^@ Belongs to the PRKRIP1 family. http://togogenome.org/gene/9646:VGLL1 ^@ http://purl.uniprot.org/uniprot/G1L838 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs.|||Nucleus http://togogenome.org/gene/9646:WAPL ^@ http://purl.uniprot.org/uniprot/G1LTK3 ^@ Similarity ^@ Belongs to the WAPL family. http://togogenome.org/gene/9646:CDSN ^@ http://purl.uniprot.org/uniprot/G1LV63 ^@ Function|||Subcellular Location Annotation ^@ Important for the epidermal barrier integrity.|||Secreted http://togogenome.org/gene/9646:GOLT1A ^@ http://purl.uniprot.org/uniprot/A0A7N5KNK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||May be involved in fusion of ER-derived transport vesicles with the Golgi complex.|||Membrane http://togogenome.org/gene/9646:HTR2A ^@ http://purl.uniprot.org/uniprot/D2H0K8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasmic vesicle|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin).|||Membrane|||Presynapse|||Synapse|||Vesicle|||axon|||caveola|||dendrite http://togogenome.org/gene/9646:CAMK1D ^@ http://purl.uniprot.org/uniprot/G1MH77 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9646:CEBPZ ^@ http://purl.uniprot.org/uniprot/G1MGU7 ^@ Similarity ^@ Belongs to the CBF/MAK21 family. http://togogenome.org/gene/9646:STAG1 ^@ http://purl.uniprot.org/uniprot/G1LII1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||centromere http://togogenome.org/gene/9646:HS3ST5 ^@ http://purl.uniprot.org/uniprot/D2HKE9 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9646:ABR ^@ http://purl.uniprot.org/uniprot/A0A7N5JX14 ^@ Subcellular Location Annotation ^@ Synapse|||axon|||dendritic spine http://togogenome.org/gene/9646:PRICKLE1 ^@ http://purl.uniprot.org/uniprot/D2HHV9 ^@ Similarity ^@ Belongs to the prickle / espinas / testin family. http://togogenome.org/gene/9646:CLP1 ^@ http://purl.uniprot.org/uniprot/D2HK67 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:ATG13 ^@ http://purl.uniprot.org/uniprot/A0A7N5JE60|||http://purl.uniprot.org/uniprot/A0A7N5JM52|||http://purl.uniprot.org/uniprot/G1LJU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.|||Belongs to the ATG13 family. Metazoan subfamily.|||Preautophagosomal structure http://togogenome.org/gene/9646:IPO13 ^@ http://purl.uniprot.org/uniprot/G1L2U6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the importin beta family.|||Cytoplasm|||Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.|||Nucleus http://togogenome.org/gene/9646:HPD ^@ http://purl.uniprot.org/uniprot/G1M7I4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 4HPPD family.|||Binds 1 Fe cation per subunit.|||Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane http://togogenome.org/gene/9646:LOC100468404 ^@ http://purl.uniprot.org/uniprot/D2H2K2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9646:MED30 ^@ http://purl.uniprot.org/uniprot/A0A7N5JJ84 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 30 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/9646:PNP ^@ http://purl.uniprot.org/uniprot/G1LFJ8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family.|||Homotrimer.|||The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. http://togogenome.org/gene/9646:EGR1 ^@ http://purl.uniprot.org/uniprot/D2HK98 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Nucleus|||Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. http://togogenome.org/gene/9646:TOP3B ^@ http://purl.uniprot.org/uniprot/G1LLS2 ^@ Function|||Similarity ^@ Belongs to the type IA topoisomerase family.|||Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. http://togogenome.org/gene/9646:LSM6 ^@ http://purl.uniprot.org/uniprot/G1ME25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/9646:MED21 ^@ http://purl.uniprot.org/uniprot/G1LYW4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 21 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9646:LOC100479790 ^@ http://purl.uniprot.org/uniprot/G1M3K6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9646:FNTB ^@ http://purl.uniprot.org/uniprot/G1L9W0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the protein prenyltransferase subunit beta family.|||Binds 1 zinc ion per subunit.|||Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.|||Heterodimer of FNTA and FNTB. http://togogenome.org/gene/9646:BLMH ^@ http://purl.uniprot.org/uniprot/G1LB93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Cytoplasm http://togogenome.org/gene/9646:EHD3 ^@ http://purl.uniprot.org/uniprot/D2HWC5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/9646:HOXB7 ^@ http://purl.uniprot.org/uniprot/D2H569 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9646:USP5 ^@ http://purl.uniprot.org/uniprot/G1M5W5 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9646:YDJC ^@ http://purl.uniprot.org/uniprot/G1LQA8 ^@ Function|||Similarity ^@ Belongs to the YdjC deacetylase family.|||Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides. http://togogenome.org/gene/9646:DXO ^@ http://purl.uniprot.org/uniprot/G1L5W1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DXO/Dom3Z family.|||Binds 2 magnesium ions.|||Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.|||Nucleus http://togogenome.org/gene/9646:VRTN ^@ http://purl.uniprot.org/uniprot/D2GZW6 ^@ Similarity ^@ Belongs to the vertnin family. http://togogenome.org/gene/9646:FAM72A ^@ http://purl.uniprot.org/uniprot/D2HZZ7|||http://purl.uniprot.org/uniprot/G1M1Z6 ^@ Similarity ^@ Belongs to the FAM72 family. http://togogenome.org/gene/9646:CTSV ^@ http://purl.uniprot.org/uniprot/D2I4U1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9646:CCR6 ^@ http://purl.uniprot.org/uniprot/A0A7N5P0J1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:METTL1 ^@ http://purl.uniprot.org/uniprot/G1LFP9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.|||Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.|||Forms a complex with WDR4.|||Nucleus|||Phosphorylation at Ser-28 inactivates its catalytic activity but does not affect the interaction with WDR4. http://togogenome.org/gene/9646:PPP2R5E ^@ http://purl.uniprot.org/uniprot/G1LBY2 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9646:HOXA1 ^@ http://purl.uniprot.org/uniprot/D2GVC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Labial subfamily.|||Nucleus http://togogenome.org/gene/9646:LOC100472954 ^@ http://purl.uniprot.org/uniprot/D2HU51 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:SERPINB7 ^@ http://purl.uniprot.org/uniprot/D2HUT2 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9646:LOC100481484 ^@ http://purl.uniprot.org/uniprot/D2H324 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9646:MUSTN1 ^@ http://purl.uniprot.org/uniprot/G1LN93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MUSTANG family.|||Nucleus http://togogenome.org/gene/9646:PPP6C ^@ http://purl.uniprot.org/uniprot/D2H3W6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/9646:MECOM ^@ http://purl.uniprot.org/uniprot/G1L5N6|||http://purl.uniprot.org/uniprot/G1L5P4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:PPP2CA ^@ http://purl.uniprot.org/uniprot/G1MHI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/9646:VPS18 ^@ http://purl.uniprot.org/uniprot/D2GW94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS18 family.|||Membrane http://togogenome.org/gene/9646:TERF2IP ^@ http://purl.uniprot.org/uniprot/D2HY19 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.|||Belongs to the RAP1 family.|||Homodimer.|||Nucleus|||telomere http://togogenome.org/gene/9646:STX4 ^@ http://purl.uniprot.org/uniprot/G1LLH9 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9646:GDPGP1 ^@ http://purl.uniprot.org/uniprot/G1MKX5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GDPGP1 family.|||Cytoplasm|||Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells. http://togogenome.org/gene/9646:SMIM19 ^@ http://purl.uniprot.org/uniprot/G1LEL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM19 family.|||Membrane http://togogenome.org/gene/9646:USO1 ^@ http://purl.uniprot.org/uniprot/G1M7I8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VDP/USO1/EDE1 family.|||Membrane http://togogenome.org/gene/9646:GPATCH1 ^@ http://purl.uniprot.org/uniprot/G1MAT3 ^@ Similarity ^@ Belongs to the GPATCH1 family. http://togogenome.org/gene/9646:TNPO1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JA56 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:RAD51 ^@ http://purl.uniprot.org/uniprot/A0A7N5P495 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Nucleus|||Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair. http://togogenome.org/gene/9646:GGPS1 ^@ http://purl.uniprot.org/uniprot/G1L2S4 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9646:GJB2 ^@ http://purl.uniprot.org/uniprot/D2I6K7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9646:RPS19 ^@ http://purl.uniprot.org/uniprot/B7SBG1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS19 family. http://togogenome.org/gene/9646:PDE7A ^@ http://purl.uniprot.org/uniprot/G1M0V5|||http://purl.uniprot.org/uniprot/G1M0V8 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9646:GPN3 ^@ http://purl.uniprot.org/uniprot/G1M5U4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.|||Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/9646:PKNOX2 ^@ http://purl.uniprot.org/uniprot/D2HNK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/9646:MEOX2 ^@ http://purl.uniprot.org/uniprot/D2H6P7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:ACP1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KC67|||http://purl.uniprot.org/uniprot/G1LSJ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.|||Belongs to the low molecular weight phosphotyrosine protein phosphatase family.|||Cytoplasm http://togogenome.org/gene/9646:THBD ^@ http://purl.uniprot.org/uniprot/D2HSG5 ^@ Caution|||Function|||Subunit ^@ Interacts with ITGAL, ITGAM and ITGB2.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. http://togogenome.org/gene/9646:LOC100478873 ^@ http://purl.uniprot.org/uniprot/D2I0D5 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:MRPL2 ^@ http://purl.uniprot.org/uniprot/G1M1M2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/9646:SLC7A6OS ^@ http://purl.uniprot.org/uniprot/D2HLJ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IWR1/SLC7A6OS family.|||Cytoplasm|||Directs RNA polymerase II nuclear import.|||Nucleus http://togogenome.org/gene/9646:CNTN1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JV13|||http://purl.uniprot.org/uniprot/A0A7N5P238 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. Contactin family. http://togogenome.org/gene/9646:NDC80 ^@ http://purl.uniprot.org/uniprot/D2HU10 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the NDC80/HEC1 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/9646:PIGF ^@ http://purl.uniprot.org/uniprot/D2GUA8 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:ACTR1B ^@ http://purl.uniprot.org/uniprot/G1LF46 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9646:IL17F ^@ http://purl.uniprot.org/uniprot/A0A7N5JBI7|||http://purl.uniprot.org/uniprot/A0A7N5JWH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/9646:GRK7 ^@ http://purl.uniprot.org/uniprot/D2H585 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9646:SLC6A11 ^@ http://purl.uniprot.org/uniprot/D2I1Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9646:NSG1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JX87 ^@ Similarity ^@ Belongs to the NSG family. http://togogenome.org/gene/9646:GYS1 ^@ http://purl.uniprot.org/uniprot/D2H7X7 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase 3 family.|||Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. http://togogenome.org/gene/9646:SPACA3 ^@ http://purl.uniprot.org/uniprot/G1LGN8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9646:WNT2 ^@ http://purl.uniprot.org/uniprot/G1L360 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9646:TESMIN ^@ http://purl.uniprot.org/uniprot/D2I297 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-54 family.|||Nucleus http://togogenome.org/gene/9646:DLL1 ^@ http://purl.uniprot.org/uniprot/G1MF60 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/9646:HAO1 ^@ http://purl.uniprot.org/uniprot/G1MC49 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/9646:LIN7C ^@ http://purl.uniprot.org/uniprot/G1M7J7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the lin-7 family.|||Cell membrane|||Lateral cell membrane|||Membrane|||Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.|||Postsynaptic density membrane|||tight junction http://togogenome.org/gene/9646:RNF34 ^@ http://purl.uniprot.org/uniprot/A0A7N5K6X6 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9646:CHRNA6 ^@ http://purl.uniprot.org/uniprot/G1LEH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9646:HOXC8 ^@ http://purl.uniprot.org/uniprot/D2HM45 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:MIPEP ^@ http://purl.uniprot.org/uniprot/D2HF51 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/9646:GSTZ1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JFW6|||http://purl.uniprot.org/uniprot/G1LAV2 ^@ Similarity ^@ Belongs to the GST superfamily. Zeta family. http://togogenome.org/gene/9646:SLC16A10 ^@ http://purl.uniprot.org/uniprot/D2I3S0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:LOC100475844 ^@ http://purl.uniprot.org/uniprot/D2I4C6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:GCNT3 ^@ http://purl.uniprot.org/uniprot/D2HV92 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:DEGS2 ^@ http://purl.uniprot.org/uniprot/D2H6V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Membrane http://togogenome.org/gene/9646:MLF2 ^@ http://purl.uniprot.org/uniprot/D2HJ12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MLF family.|||Cytoplasm http://togogenome.org/gene/9646:IQCD ^@ http://purl.uniprot.org/uniprot/G1LQ84 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC10 family.|||Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.|||flagellum axoneme http://togogenome.org/gene/9646:CHRNA9 ^@ http://purl.uniprot.org/uniprot/D2I181 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9646:STAT6 ^@ http://purl.uniprot.org/uniprot/D2H375 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:SLC5A12 ^@ http://purl.uniprot.org/uniprot/G1LCK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:KCNH8 ^@ http://purl.uniprot.org/uniprot/G1LLM3 ^@ Subcellular Location Annotation|||Subunit ^@ Membrane|||The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. http://togogenome.org/gene/9646:GSK3B ^@ http://purl.uniprot.org/uniprot/G1LKA6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. http://togogenome.org/gene/9646:RAP2B ^@ http://purl.uniprot.org/uniprot/D2H407 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Palmitoylated.|||Recycling endosome membrane|||Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. http://togogenome.org/gene/9646:SS18 ^@ http://purl.uniprot.org/uniprot/A0A7N5JW36|||http://purl.uniprot.org/uniprot/G1M6F9 ^@ Similarity ^@ Belongs to the SS18 family. http://togogenome.org/gene/9646:APAF1 ^@ http://purl.uniprot.org/uniprot/G1LWB3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Monomer. Oligomerizes upon binding of cytochrome c and dATP.|||Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. http://togogenome.org/gene/9646:RSAD2 ^@ http://purl.uniprot.org/uniprot/D2HGH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RSAD2 family.|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion inner membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9646:LACC1 ^@ http://purl.uniprot.org/uniprot/D2H0I9 ^@ Similarity ^@ Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family. http://togogenome.org/gene/9646:DEDD ^@ http://purl.uniprot.org/uniprot/A0A7N5KPY5 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9646:SH3BGRL ^@ http://purl.uniprot.org/uniprot/A0A7N5JZR6 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/9646:PLD1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JAP3|||http://purl.uniprot.org/uniprot/D2HHF7 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/9646:TMEM120B ^@ http://purl.uniprot.org/uniprot/G1M791 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM120 family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/9646:ACVR2A ^@ http://purl.uniprot.org/uniprot/G1M4A6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9646:APP ^@ http://purl.uniprot.org/uniprot/A0A7N5JN45|||http://purl.uniprot.org/uniprot/A0A7N5JSB7|||http://purl.uniprot.org/uniprot/A0A7N5K3J6|||http://purl.uniprot.org/uniprot/G1MFV5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APP family.|||Cell membrane|||Cell surface|||Cytoplasmic vesicle|||Early endosome|||Endosome|||Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.|||Golgi apparatus|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).|||Nucleus|||Perikaryon|||Secreted|||The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.|||Vesicle|||clathrin-coated pit|||growth cone http://togogenome.org/gene/9646:RAB3GAP2 ^@ http://purl.uniprot.org/uniprot/G1LUD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab3-GAP regulatory subunit family.|||Cytoplasm http://togogenome.org/gene/9646:MCM9 ^@ http://purl.uniprot.org/uniprot/A0A7N5JP55|||http://purl.uniprot.org/uniprot/G1LA69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Chromosome|||Nucleus http://togogenome.org/gene/9646:DPPA5 ^@ http://purl.uniprot.org/uniprot/D2H4J1 ^@ Similarity ^@ Belongs to the KHDC1 family. http://togogenome.org/gene/9646:PLSCR5 ^@ http://purl.uniprot.org/uniprot/G1L5R4 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/9646:TMLHE ^@ http://purl.uniprot.org/uniprot/D2I4U4 ^@ Similarity ^@ Belongs to the gamma-BBH/TMLD family. http://togogenome.org/gene/9646:LANCL2 ^@ http://purl.uniprot.org/uniprot/G1LRL3 ^@ Similarity ^@ Belongs to the LanC-like protein family. http://togogenome.org/gene/9646:IRF6 ^@ http://purl.uniprot.org/uniprot/D2HIJ4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:TMEM182 ^@ http://purl.uniprot.org/uniprot/A0A7N5KAC2|||http://purl.uniprot.org/uniprot/A0A7N5KLB7|||http://purl.uniprot.org/uniprot/A0A7N5P4H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM182 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:EBP ^@ http://purl.uniprot.org/uniprot/D2H7P2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:PROKR2 ^@ http://purl.uniprot.org/uniprot/D2HQS9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:SCAMP2 ^@ http://purl.uniprot.org/uniprot/G1LQ66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/9646:ATP6V1F ^@ http://purl.uniprot.org/uniprot/D2GWS3 ^@ Similarity ^@ Belongs to the V-ATPase F subunit family. http://togogenome.org/gene/9646:HOXA6 ^@ http://purl.uniprot.org/uniprot/D2GVB9|||http://purl.uniprot.org/uniprot/G1LH22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9646:BCAP31 ^@ http://purl.uniprot.org/uniprot/G1LQ55 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCAP29/BCAP31 family.|||Endoplasmic reticulum membrane|||Membrane|||Plays a role in the export of secreted proteins in the ER. http://togogenome.org/gene/9646:CEP57 ^@ http://purl.uniprot.org/uniprot/A0A7N5JJS6 ^@ Similarity ^@ Belongs to the translokin family. http://togogenome.org/gene/9646:DCAF11 ^@ http://purl.uniprot.org/uniprot/D2HG59 ^@ Function|||Subunit ^@ Interacts with DDB1 and CUL4A.|||May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. http://togogenome.org/gene/9646:RPL10L ^@ http://purl.uniprot.org/uniprot/D2HWA8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/9646:TUBE1 ^@ http://purl.uniprot.org/uniprot/D2H642 ^@ Similarity ^@ Belongs to the tubulin family. http://togogenome.org/gene/9646:MMUT ^@ http://purl.uniprot.org/uniprot/D2H1P9 ^@ Function|||Similarity ^@ Belongs to the methylmalonyl-CoA mutase family.|||Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle. http://togogenome.org/gene/9646:ASAH1 ^@ http://purl.uniprot.org/uniprot/G1M4K5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acid ceramidase family.|||Heterodimer.|||Lysosome http://togogenome.org/gene/9646:RIPPLY1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KED5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ripply family.|||Nucleus http://togogenome.org/gene/9646:MANBA ^@ http://purl.uniprot.org/uniprot/G1LQX2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 2 family.|||Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.|||Lysosome|||Monomer. http://togogenome.org/gene/9646:HNF4A ^@ http://purl.uniprot.org/uniprot/A0A7N5KKW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9646:MANEA ^@ http://purl.uniprot.org/uniprot/D2I2H7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 99 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:LOC100478524 ^@ http://purl.uniprot.org/uniprot/D2I307 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:SEMA3E ^@ http://purl.uniprot.org/uniprot/A0A7N5P488 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the semaphorin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:LAMC1 ^@ http://purl.uniprot.org/uniprot/D2HN94 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||basement membrane http://togogenome.org/gene/9646:ADAMTS6 ^@ http://purl.uniprot.org/uniprot/G1LXA0 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9646:PDCL2 ^@ http://purl.uniprot.org/uniprot/G1MJD9 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9646:SERPINE1 ^@ http://purl.uniprot.org/uniprot/D2I5Z6 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9646:RPRD1B ^@ http://purl.uniprot.org/uniprot/D2H111 ^@ Function|||Similarity|||Subunit ^@ Associates with the RNA polymerase II complex.|||Belongs to the UPF0400 (RTT103) family.|||Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. http://togogenome.org/gene/9646:LOC100484971 ^@ http://purl.uniprot.org/uniprot/D2HWP2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing.|||cytosol http://togogenome.org/gene/9646:SKA1 ^@ http://purl.uniprot.org/uniprot/D2I4J3 ^@ Similarity ^@ Belongs to the SKA1 family. http://togogenome.org/gene/9646:SNRPC ^@ http://purl.uniprot.org/uniprot/A0A7N5K7W1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the U1 small nuclear ribonucleoprotein C family.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Nucleus|||U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. http://togogenome.org/gene/9646:ANAPC16 ^@ http://purl.uniprot.org/uniprot/D2HZB3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APC16 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|||Cytoplasm|||Nucleus|||kinetochore http://togogenome.org/gene/9646:PATZ1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JHD1|||http://purl.uniprot.org/uniprot/A0A7N5JLY8|||http://purl.uniprot.org/uniprot/D2H203 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:UXT ^@ http://purl.uniprot.org/uniprot/A0A7N5JW33 ^@ Similarity ^@ Belongs to the UXT family. http://togogenome.org/gene/9646:CCNB3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JID9 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9646:SNURF ^@ http://purl.uniprot.org/uniprot/G1LKD6 ^@ Similarity ^@ Belongs to the SNURF family. http://togogenome.org/gene/9646:GBX1 ^@ http://purl.uniprot.org/uniprot/D2H1V6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:PURA ^@ http://purl.uniprot.org/uniprot/D2GUP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PUR DNA-binding protein family.|||Nucleus http://togogenome.org/gene/9646:PPP1R2 ^@ http://purl.uniprot.org/uniprot/G1LS51 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 2 family. http://togogenome.org/gene/9646:NDUFAF1 ^@ http://purl.uniprot.org/uniprot/D2GW87 ^@ Function|||Similarity ^@ As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.|||Belongs to the CIA30 family. http://togogenome.org/gene/9646:FLOT1 ^@ http://purl.uniprot.org/uniprot/G1M3G5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily.|||Cell membrane|||Endosome|||Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.|||Membrane|||caveola http://togogenome.org/gene/9646:TSG101 ^@ http://purl.uniprot.org/uniprot/G1MHQ6 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily. http://togogenome.org/gene/9646:RPS15A ^@ http://purl.uniprot.org/uniprot/D3YBZ8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS8 family. http://togogenome.org/gene/9646:CAV1 ^@ http://purl.uniprot.org/uniprot/A0A7N5P9J7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||caveola http://togogenome.org/gene/9646:LOC100479705 ^@ http://purl.uniprot.org/uniprot/G1MM69 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:MYADML2 ^@ http://purl.uniprot.org/uniprot/D2GVE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAL family.|||Membrane http://togogenome.org/gene/9646:LOC100472839 ^@ http://purl.uniprot.org/uniprot/G1M079 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.|||Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.|||Secreted|||When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14. http://togogenome.org/gene/9646:LOC100480434 ^@ http://purl.uniprot.org/uniprot/D2HK74 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:SEPSECS ^@ http://purl.uniprot.org/uniprot/D2I455 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SepSecS family.|||Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.|||Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer. http://togogenome.org/gene/9646:ATP4B ^@ http://purl.uniprot.org/uniprot/D2HTR9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9646:LLPH ^@ http://purl.uniprot.org/uniprot/D2HQH7 ^@ Similarity ^@ Belongs to the learning-associated protein family. http://togogenome.org/gene/9646:SLC2A2 ^@ http://purl.uniprot.org/uniprot/G1LDS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:LOC100465213 ^@ http://purl.uniprot.org/uniprot/F2X266 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/9646:JAK3 ^@ http://purl.uniprot.org/uniprot/D2GV17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Endomembrane system http://togogenome.org/gene/9646:SMG8 ^@ http://purl.uniprot.org/uniprot/D2HLV2 ^@ Function|||Similarity ^@ Belongs to the SMG8 family.|||Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. http://togogenome.org/gene/9646:WDR3 ^@ http://purl.uniprot.org/uniprot/D2HQ25 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9646:LIPH ^@ http://purl.uniprot.org/uniprot/G1MEH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9646:CARTPT ^@ http://purl.uniprot.org/uniprot/D2H2V1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CART family.|||Secreted http://togogenome.org/gene/9646:AMPD3 ^@ http://purl.uniprot.org/uniprot/G1LA55 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/9646:SLC43A2 ^@ http://purl.uniprot.org/uniprot/G1LN45 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:PXMP4 ^@ http://purl.uniprot.org/uniprot/G1LQY5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Interacts with PEX19.|||Peroxisome membrane http://togogenome.org/gene/9646:ABI2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JDP3|||http://purl.uniprot.org/uniprot/D2HB84|||http://purl.uniprot.org/uniprot/G1M2U2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABI family.|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/9646:SPOPL ^@ http://purl.uniprot.org/uniprot/D2HPC9 ^@ Similarity ^@ Belongs to the Tdpoz family. http://togogenome.org/gene/9646:PRDX6 ^@ http://purl.uniprot.org/uniprot/D2H5H7 ^@ Similarity ^@ Belongs to the peroxiredoxin family. Prx6 subfamily. http://togogenome.org/gene/9646:DLAT ^@ http://purl.uniprot.org/uniprot/D2HG83 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Binds 2 lipoyl cofactors covalently.|||Mitochondrion matrix|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). http://togogenome.org/gene/9646:NIPSNAP2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JU58 ^@ Similarity ^@ Belongs to the NipSnap family. http://togogenome.org/gene/9646:GORASP2 ^@ http://purl.uniprot.org/uniprot/G1LQ80 ^@ Similarity ^@ Belongs to the GORASP family. http://togogenome.org/gene/9646:SNU13 ^@ http://purl.uniprot.org/uniprot/G1MAQ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/9646:SMIM12 ^@ http://purl.uniprot.org/uniprot/D2H617 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM12 family.|||Membrane http://togogenome.org/gene/9646:MED17 ^@ http://purl.uniprot.org/uniprot/D2I2X9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 17 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9646:GJA8 ^@ http://purl.uniprot.org/uniprot/D2HQ39 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9646:COL4A5 ^@ http://purl.uniprot.org/uniprot/G1M069|||http://purl.uniprot.org/uniprot/G1M077 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.|||basement membrane http://togogenome.org/gene/9646:HBE1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JUX4 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9646:NPRL3 ^@ http://purl.uniprot.org/uniprot/D2HDV0|||http://purl.uniprot.org/uniprot/G1LJW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway.|||Belongs to the NPR3 family.|||Lysosome http://togogenome.org/gene/9646:TES ^@ http://purl.uniprot.org/uniprot/A0A7N5KSQ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prickle / espinas / testin family.|||Cytoplasm|||Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN (By similarity). Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer.|||Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor.|||focal adhesion http://togogenome.org/gene/9646:MAB21L1 ^@ http://purl.uniprot.org/uniprot/D2HM76 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9646:GNPDA2 ^@ http://purl.uniprot.org/uniprot/A0A7N5P203 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/9646:RIDA ^@ http://purl.uniprot.org/uniprot/G1L170 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RutC family.|||Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.|||Peroxisome http://togogenome.org/gene/9646:LOXHD1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JMH8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:GH1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JGI6|||http://purl.uniprot.org/uniprot/Q8HYE5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues (By similarity).|||Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.|||Secreted http://togogenome.org/gene/9646:SMAD5 ^@ http://purl.uniprot.org/uniprot/D2GVL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:TAS2R40 ^@ http://purl.uniprot.org/uniprot/D2HP48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9646:RPLP2 ^@ http://purl.uniprot.org/uniprot/F2X232 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/9646:TADA1 ^@ http://purl.uniprot.org/uniprot/G1M675 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TADA1 family.|||Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.|||Nucleus|||Probably involved in transcriptional regulation. http://togogenome.org/gene/9646:GTF2F2 ^@ http://purl.uniprot.org/uniprot/G1M2Y9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIF beta subunit family.|||Nucleus|||TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. http://togogenome.org/gene/9646:C14H22orf39 ^@ http://purl.uniprot.org/uniprot/A0A7N5JQV6 ^@ Similarity ^@ Belongs to the UPF0545 family. http://togogenome.org/gene/9646:ABL2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JA84|||http://purl.uniprot.org/uniprot/A0A7N5JKZ5|||http://purl.uniprot.org/uniprot/G1M7W8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane http://togogenome.org/gene/9646:EXTL2 ^@ http://purl.uniprot.org/uniprot/A0A7N5K0I0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:CDC42BPA ^@ http://purl.uniprot.org/uniprot/A0A7N5JJ91|||http://purl.uniprot.org/uniprot/G1LQY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.|||Cytoplasm|||lamellipodium http://togogenome.org/gene/9646:FAT2 ^@ http://purl.uniprot.org/uniprot/D2HFC7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:TRHR ^@ http://purl.uniprot.org/uniprot/D2HA59 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. http://togogenome.org/gene/9646:AARS1 ^@ http://purl.uniprot.org/uniprot/G1LE07 ^@ Cofactor|||Domain|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||ISGylated.|||Monomer. Interacts with ANKRD16; the interaction is direct. http://togogenome.org/gene/9646:PRODH2 ^@ http://purl.uniprot.org/uniprot/G1L1G5 ^@ Function|||Similarity ^@ Belongs to the proline oxidase family.|||Converts proline to delta-1-pyrroline-5-carboxylate. http://togogenome.org/gene/9646:ACO2 ^@ http://purl.uniprot.org/uniprot/G1MB13 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.|||Mitochondrion http://togogenome.org/gene/9646:STARD8 ^@ http://purl.uniprot.org/uniprot/G1L694 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:TAS1R2 ^@ http://purl.uniprot.org/uniprot/D2HVZ2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9646:HTR1A ^@ http://purl.uniprot.org/uniprot/D2HUM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.|||Membrane|||dendrite http://togogenome.org/gene/9646:PUS10 ^@ http://purl.uniprot.org/uniprot/G1MIU3 ^@ Similarity ^@ Belongs to the pseudouridine synthase Pus10 family. http://togogenome.org/gene/9646:WDR12 ^@ http://purl.uniprot.org/uniprot/G1M3A0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat WDR12/YTM1 family.|||Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.|||Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9646:HNRNPK ^@ http://purl.uniprot.org/uniprot/G1LB97 ^@ Subcellular Location Annotation ^@ Cytoplasm|||nucleoplasm|||podosome http://togogenome.org/gene/9646:ESCO2 ^@ http://purl.uniprot.org/uniprot/A0A7N5PAQ7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:DAG1 ^@ http://purl.uniprot.org/uniprot/D2HEU8 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.|||Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.|||cytoskeleton|||extracellular space|||nucleoplasm|||sarcolemma http://togogenome.org/gene/9646:SEPTIN14 ^@ http://purl.uniprot.org/uniprot/G1MCL0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9646:ARSJ ^@ http://purl.uniprot.org/uniprot/A0A7N5P9Y7 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9646:CCNO ^@ http://purl.uniprot.org/uniprot/D2I0X7 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9646:MRPL14 ^@ http://purl.uniprot.org/uniprot/G1M040 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL14 family. http://togogenome.org/gene/9646:LOC100479661 ^@ http://purl.uniprot.org/uniprot/A0A7N5P8M9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family.|||Binds 2 Zn(2+) ions per subunit.|||Cytoplasm http://togogenome.org/gene/9646:ATP6V1C1 ^@ http://purl.uniprot.org/uniprot/D2HJW7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits. http://togogenome.org/gene/9646:SDHD ^@ http://purl.uniprot.org/uniprot/G1LBK9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CybS family.|||Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.|||Membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/9646:USP3 ^@ http://purl.uniprot.org/uniprot/D2GYQ7 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9646:SLC4A4 ^@ http://purl.uniprot.org/uniprot/G1LHJ5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9646:EGFL8 ^@ http://purl.uniprot.org/uniprot/A0A7N5K8U7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:MAT1A ^@ http://purl.uniprot.org/uniprot/D2HJG2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/9646:LOC100469449 ^@ http://purl.uniprot.org/uniprot/D2HWI7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9646:ATP5PD ^@ http://purl.uniprot.org/uniprot/D2HD33 ^@ Function|||Similarity ^@ Belongs to the ATPase d subunit family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. http://togogenome.org/gene/9646:SERPINA14 ^@ http://purl.uniprot.org/uniprot/F9W2V9 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9646:HSD17B7 ^@ http://purl.uniprot.org/uniprot/G1L3U6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily. http://togogenome.org/gene/9646:HSD3B1 ^@ http://purl.uniprot.org/uniprot/G1MH48 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9646:N6AMT1 ^@ http://purl.uniprot.org/uniprot/D2HGA9 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal PrmC-related family. http://togogenome.org/gene/9646:LOC100470134 ^@ http://purl.uniprot.org/uniprot/A0A7N5P6E3|||http://purl.uniprot.org/uniprot/G1M4M8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uricase family.|||Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.|||Peroxisome http://togogenome.org/gene/9646:TMEM59 ^@ http://purl.uniprot.org/uniprot/D2H2G2|||http://purl.uniprot.org/uniprot/G1LT40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM59 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:VAMP7 ^@ http://purl.uniprot.org/uniprot/A0A7N5KH14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9646:NAP1L3 ^@ http://purl.uniprot.org/uniprot/D2I213 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9646:LYG2 ^@ http://purl.uniprot.org/uniprot/G1M3Y2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 23 family. http://togogenome.org/gene/9646:GRWD1 ^@ http://purl.uniprot.org/uniprot/D2H7Z8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:MED24 ^@ http://purl.uniprot.org/uniprot/D2I2E8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 24 family.|||Nucleus http://togogenome.org/gene/9646:TNFSF8 ^@ http://purl.uniprot.org/uniprot/D2H2H7 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9646:CNDP2 ^@ http://purl.uniprot.org/uniprot/G1LD33 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20A family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9646:LOC100479513 ^@ http://purl.uniprot.org/uniprot/G1ML81 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:MRPS18B ^@ http://purl.uniprot.org/uniprot/G1M3S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.|||Mitochondrion http://togogenome.org/gene/9646:NUP98 ^@ http://purl.uniprot.org/uniprot/G1LWU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin GLFG family.|||Nucleus membrane|||nuclear pore complex http://togogenome.org/gene/9646:H1-1 ^@ http://purl.uniprot.org/uniprot/D2I077 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9646:RNF20 ^@ http://purl.uniprot.org/uniprot/G1L1A0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BRE1 family.|||Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.|||Nucleus http://togogenome.org/gene/9646:NFYA ^@ http://purl.uniprot.org/uniprot/A0A7N5JZH7|||http://purl.uniprot.org/uniprot/G1LCR2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NFYA/HAP2 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.|||Heterotrimer.|||Nucleus http://togogenome.org/gene/9646:MIOS ^@ http://purl.uniprot.org/uniprot/A0A7N5KDF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat mio family.|||Lysosome membrane http://togogenome.org/gene/9646:ITM2B ^@ http://purl.uniprot.org/uniprot/G1LAI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITM2 family.|||Membrane http://togogenome.org/gene/9646:SIAH3 ^@ http://purl.uniprot.org/uniprot/D2H0K2 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/9646:CNOT7 ^@ http://purl.uniprot.org/uniprot/D2HN30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/9646:ARFGEF2 ^@ http://purl.uniprot.org/uniprot/D2GVP9 ^@ Subcellular Location Annotation ^@ Golgi apparatus|||perinuclear region http://togogenome.org/gene/9646:SLC6A20 ^@ http://purl.uniprot.org/uniprot/D2GV75 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:KCNJ3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JTZ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.|||Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.|||Membrane|||This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat. http://togogenome.org/gene/9646:LOC100477187 ^@ http://purl.uniprot.org/uniprot/G1MM28 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9646:LOC100468897 ^@ http://purl.uniprot.org/uniprot/F2X213 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS10 family. http://togogenome.org/gene/9646:SBDS ^@ http://purl.uniprot.org/uniprot/D2HW33 ^@ Function|||Similarity ^@ Belongs to the SDO1/SBDS family.|||Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. http://togogenome.org/gene/9646:CCNB2 ^@ http://purl.uniprot.org/uniprot/G1LDA3 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9646:MTX2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JLG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metaxin family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9646:VGLL4 ^@ http://purl.uniprot.org/uniprot/A0A7N5JF31|||http://purl.uniprot.org/uniprot/A0A7N5JSQ1|||http://purl.uniprot.org/uniprot/G1LWX7|||http://purl.uniprot.org/uniprot/G1LWY3 ^@ Function|||Similarity ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs. http://togogenome.org/gene/9646:EMC7 ^@ http://purl.uniprot.org/uniprot/D2HRS2 ^@ Similarity|||Subunit ^@ Belongs to the EMC7 family.|||Component of the ER membrane protein complex (EMC). http://togogenome.org/gene/9646:CDC73 ^@ http://purl.uniprot.org/uniprot/A0A7N5KIN1|||http://purl.uniprot.org/uniprot/G1MBL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC73 family.|||Nucleus http://togogenome.org/gene/9646:RPS3 ^@ http://purl.uniprot.org/uniprot/F2X1Z9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS3 family.|||Membrane|||Mitochondrion inner membrane|||spindle http://togogenome.org/gene/9646:ATP13A5 ^@ http://purl.uniprot.org/uniprot/G1MBW2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:PTGS2 ^@ http://purl.uniprot.org/uniprot/G1MAL9 ^@ Caution|||Similarity ^@ Belongs to the prostaglandin G/H synthase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:DMC1 ^@ http://purl.uniprot.org/uniprot/G1LVW5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. DMC1 subfamily.|||May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.|||Nucleus http://togogenome.org/gene/9646:CHCHD4 ^@ http://purl.uniprot.org/uniprot/G1LS95 ^@ Subcellular Location Annotation ^@ Mitochondrion intermembrane space http://togogenome.org/gene/9646:LOC100468463 ^@ http://purl.uniprot.org/uniprot/G1MN24 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:PLA2G4A ^@ http://purl.uniprot.org/uniprot/G1MAR8 ^@ Domain ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding. http://togogenome.org/gene/9646:LOC100471943 ^@ http://purl.uniprot.org/uniprot/D2HI69 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:TOM1L1 ^@ http://purl.uniprot.org/uniprot/G1M7Z6 ^@ Similarity ^@ Belongs to the TOM1 family. http://togogenome.org/gene/9646:AMT ^@ http://purl.uniprot.org/uniprot/D2HEV0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvT family.|||Mitochondrion|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/9646:MSH6 ^@ http://purl.uniprot.org/uniprot/D2GUB6 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||Component of the post-replicative DNA mismatch repair system (MMR). http://togogenome.org/gene/9646:FOXG1 ^@ http://purl.uniprot.org/uniprot/D2HJI4 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. http://togogenome.org/gene/9646:ARL5B ^@ http://purl.uniprot.org/uniprot/A0A7N5KBS5 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9646:ARHGEF12 ^@ http://purl.uniprot.org/uniprot/A0A7N5KPZ9|||http://purl.uniprot.org/uniprot/G1LN95 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Membrane http://togogenome.org/gene/9646:SLC26A3 ^@ http://purl.uniprot.org/uniprot/G1M5R6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.|||Membrane http://togogenome.org/gene/9646:TMEM176B ^@ http://purl.uniprot.org/uniprot/D2H1W4 ^@ Similarity ^@ Belongs to the TMEM176 family. http://togogenome.org/gene/9646:SMAD1 ^@ http://purl.uniprot.org/uniprot/D2H3Q3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:LOC100477944 ^@ http://purl.uniprot.org/uniprot/D2I5Y2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:UGCG ^@ http://purl.uniprot.org/uniprot/D2H4E2 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/9646:OGT ^@ http://purl.uniprot.org/uniprot/G1MCJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.|||Cell projection|||Mitochondrion membrane http://togogenome.org/gene/9646:LOC100473638 ^@ http://purl.uniprot.org/uniprot/D2HGS3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/9646:SPICE1 ^@ http://purl.uniprot.org/uniprot/G1LEY1 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with CEP120.|||centriole|||spindle http://togogenome.org/gene/9646:F10 ^@ http://purl.uniprot.org/uniprot/G1LUQ6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9646:TMBIM4 ^@ http://purl.uniprot.org/uniprot/G1KZQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9646:PDE6G ^@ http://purl.uniprot.org/uniprot/G1MGS6 ^@ Function|||Similarity ^@ Belongs to the rod/cone cGMP-PDE gamma subunit family.|||Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. http://togogenome.org/gene/9646:TRPM7 ^@ http://purl.uniprot.org/uniprot/G1LR58 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.|||Membrane http://togogenome.org/gene/9646:NQO1 ^@ http://purl.uniprot.org/uniprot/G1LJI8 ^@ Similarity ^@ Belongs to the NAD(P)H dehydrogenase (quinone) family. http://togogenome.org/gene/9646:BTK ^@ http://purl.uniprot.org/uniprot/A0A7N5K6N1|||http://purl.uniprot.org/uniprot/G1LS18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane http://togogenome.org/gene/9646:SPG21 ^@ http://purl.uniprot.org/uniprot/A0A7N5P5I3 ^@ Function ^@ May play a role as a negative regulatory factor in CD4-dependent T-cell activation. http://togogenome.org/gene/9646:SERPINB12 ^@ http://purl.uniprot.org/uniprot/D2H6Z8 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9646:LOC100464876 ^@ http://purl.uniprot.org/uniprot/D2GUE7 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/9646:CPNE1 ^@ http://purl.uniprot.org/uniprot/G1LTK9|||http://purl.uniprot.org/uniprot/G1MLJ9 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9646:LOC100465190 ^@ http://purl.uniprot.org/uniprot/D2HWJ3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9646:PHKA1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JN92|||http://purl.uniprot.org/uniprot/A0A7N5K670|||http://purl.uniprot.org/uniprot/A0A7N5PAX1|||http://purl.uniprot.org/uniprot/G1LH67 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.|||Belongs to the phosphorylase b kinase regulatory chain family.|||Cell membrane|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.|||Membrane|||Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. http://togogenome.org/gene/9646:FAM3D ^@ http://purl.uniprot.org/uniprot/G1M0A2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/9646:CNOT2 ^@ http://purl.uniprot.org/uniprot/G1LZS8 ^@ Similarity ^@ Belongs to the CNOT2/3/5 family. http://togogenome.org/gene/9646:SLC17A7 ^@ http://purl.uniprot.org/uniprot/G1M6F1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:ZDHHC17 ^@ http://purl.uniprot.org/uniprot/G1LJ71 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9646:NDUFB6 ^@ http://purl.uniprot.org/uniprot/A0A7N5KBT6|||http://purl.uniprot.org/uniprot/G1LAX3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB6 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:KCNE3 ^@ http://purl.uniprot.org/uniprot/D2H1E4 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/9646:HMCES ^@ http://purl.uniprot.org/uniprot/G1M9S9 ^@ Function|||Similarity ^@ Belongs to the SOS response-associated peptidase family.|||Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction. http://togogenome.org/gene/9646:CAPZA1 ^@ http://purl.uniprot.org/uniprot/G1LA48 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/9646:TRAPPC6A ^@ http://purl.uniprot.org/uniprot/G1M1R7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||cis-Golgi network http://togogenome.org/gene/9646:ARL8A ^@ http://purl.uniprot.org/uniprot/G1LZT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||spindle http://togogenome.org/gene/9646:GET3 ^@ http://purl.uniprot.org/uniprot/G1M0I7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.|||Belongs to the arsA ATPase family.|||Cytoplasm|||Endoplasmic reticulum|||Homodimer. Component of a transmembrane domain recognition complex (TRC). Interacts with SERP1 and SEC61B. Interacts with WRB.|||nucleolus http://togogenome.org/gene/9646:RPL8 ^@ http://purl.uniprot.org/uniprot/F2X241 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/9646:SERBP1 ^@ http://purl.uniprot.org/uniprot/G1LD20 ^@ Similarity ^@ Belongs to the SERBP1-HABP4 family. http://togogenome.org/gene/9646:PRLHR ^@ http://purl.uniprot.org/uniprot/D2H1L4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:LOC100466687 ^@ http://purl.uniprot.org/uniprot/G1LCL9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.|||Membrane|||Microsome membrane http://togogenome.org/gene/9646:FCF1 ^@ http://purl.uniprot.org/uniprot/G1MJ01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP23/FCF1 family. FCF1 subfamily.|||nucleolus http://togogenome.org/gene/9646:ATP6V1C2 ^@ http://purl.uniprot.org/uniprot/A0A7N5KHU0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits. http://togogenome.org/gene/9646:CLIC1 ^@ http://purl.uniprot.org/uniprot/G1LRE0 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cell membrane|||Cytoplasm|||Endoplasmic reticulum|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane|||Nucleus membrane http://togogenome.org/gene/9646:LUC7L3 ^@ http://purl.uniprot.org/uniprot/D2HTT6|||http://purl.uniprot.org/uniprot/G1LMK4 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/9646:HOGA1 ^@ http://purl.uniprot.org/uniprot/D2H5K6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the final step in the metabolic pathway of hydroxyproline.|||Homotetramer. http://togogenome.org/gene/9646:TMEM150B ^@ http://purl.uniprot.org/uniprot/G1LAJ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:CAPN1 ^@ http://purl.uniprot.org/uniprot/G1MH21 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9646:TM9SF2 ^@ http://purl.uniprot.org/uniprot/G1LCS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/9646:STX6 ^@ http://purl.uniprot.org/uniprot/G1L7Y4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Golgi apparatus membrane http://togogenome.org/gene/9646:EIF3H ^@ http://purl.uniprot.org/uniprot/G1LUW5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit H family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm http://togogenome.org/gene/9646:SLC10A2 ^@ http://purl.uniprot.org/uniprot/G1MDC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/9646:ITGB3BP ^@ http://purl.uniprot.org/uniprot/A0A7N5JTT0 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Transcription coregulator that can have both coactivator and corepressor functions.|||centromere|||kinetochore http://togogenome.org/gene/9646:LOC100499573 ^@ http://purl.uniprot.org/uniprot/P18983 ^@ Function|||Similarity|||Subunit|||Tissue Specificity ^@ Belongs to the globin family.|||Heterotetramer of two alpha chains and two beta chains.|||Involved in oxygen transport from the lung to the various peripheral tissues.|||Red blood cells. http://togogenome.org/gene/9646:BRAT1 ^@ http://purl.uniprot.org/uniprot/D2I4M3 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with BRCA1 and ATM. Interacts with MTOR, RPTOR, NDFIP1, SMC1A and PRKDC.|||Involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress. Plays a role in regulating mitochondrial function and cell proliferation. Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors.|||Nucleus|||Ubiquitinated by NEDD4, NEDD4L and ITCH; mono- and polyubiquitinated forms are detected. http://togogenome.org/gene/9646:NDUFA13 ^@ http://purl.uniprot.org/uniprot/G1LZK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I NDUFA13 subunit family.|||Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:LOC100478119 ^@ http://purl.uniprot.org/uniprot/D2I4D3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:GABRA3 ^@ http://purl.uniprot.org/uniprot/G1M0C2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9646:MTAP ^@ http://purl.uniprot.org/uniprot/G1LLW1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.|||Cytoplasm|||Homotrimer.|||Nucleus http://togogenome.org/gene/9646:LOC100484059 ^@ http://purl.uniprot.org/uniprot/G1MCH8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:GNG11 ^@ http://purl.uniprot.org/uniprot/D2H8V0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9646:GAPDHS ^@ http://purl.uniprot.org/uniprot/G1L0I3 ^@ Similarity|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/9646:SHMT2 ^@ http://purl.uniprot.org/uniprot/G1LDQ8 ^@ Function|||Similarity ^@ Belongs to the SHMT family.|||Interconversion of serine and glycine. http://togogenome.org/gene/9646:SPX ^@ http://purl.uniprot.org/uniprot/G1MCQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the spexin family.|||Secreted http://togogenome.org/gene/9646:SLC35E3 ^@ http://purl.uniprot.org/uniprot/G1LPM9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:ZDHHC16 ^@ http://purl.uniprot.org/uniprot/A0A7N5JR20|||http://purl.uniprot.org/uniprot/D2H5K9 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9646:CCDC153 ^@ http://purl.uniprot.org/uniprot/G1KZI1 ^@ Similarity ^@ Belongs to the UPF0610 family. http://togogenome.org/gene/9646:GNG3 ^@ http://purl.uniprot.org/uniprot/D2HS78 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9646:CACYBP ^@ http://purl.uniprot.org/uniprot/G1KZY6 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).|||Nucleus http://togogenome.org/gene/9646:MRPL11 ^@ http://purl.uniprot.org/uniprot/G1LXY6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL11 family. http://togogenome.org/gene/9646:MFAP5 ^@ http://purl.uniprot.org/uniprot/A0A7N5P2B8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MFAP family.|||extracellular matrix http://togogenome.org/gene/9646:PHGDH ^@ http://purl.uniprot.org/uniprot/D2HZW5 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/9646:AGBL2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JSA9|||http://purl.uniprot.org/uniprot/A0A7N5KCW1|||http://purl.uniprot.org/uniprot/A0A7N5KQD6|||http://purl.uniprot.org/uniprot/G1LMG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||cytosol http://togogenome.org/gene/9646:HTRA2 ^@ http://purl.uniprot.org/uniprot/D2HH54 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/9646:PTPRA ^@ http://purl.uniprot.org/uniprot/G1LX95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:IFRD2 ^@ http://purl.uniprot.org/uniprot/G1LZ64 ^@ Similarity ^@ Belongs to the IFRD family. http://togogenome.org/gene/9646:SUPT5H ^@ http://purl.uniprot.org/uniprot/A0A7N5K4V1|||http://purl.uniprot.org/uniprot/G1LPC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT5 family.|||Nucleus http://togogenome.org/gene/9646:DNM1L ^@ http://purl.uniprot.org/uniprot/G1LQV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.|||Cytoplasm http://togogenome.org/gene/9646:NUP205 ^@ http://purl.uniprot.org/uniprot/G1M049 ^@ Similarity ^@ Belongs to the NUP186/NUP192/NUP205 family. http://togogenome.org/gene/9646:GPR12 ^@ http://purl.uniprot.org/uniprot/D2HP86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:HYAL4 ^@ http://purl.uniprot.org/uniprot/G1LD27 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/9646:PLA2G4E ^@ http://purl.uniprot.org/uniprot/G1MD23 ^@ Domain|||Subcellular Location Annotation ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding.|||cytosol http://togogenome.org/gene/9646:BANF2 ^@ http://purl.uniprot.org/uniprot/D2HRE2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:HARS1 ^@ http://purl.uniprot.org/uniprot/D2GUN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/9646:LOC100477384 ^@ http://purl.uniprot.org/uniprot/D2H4E3 ^@ Similarity ^@ Belongs to the DNAJC25 family. http://togogenome.org/gene/9646:CFL1 ^@ http://purl.uniprot.org/uniprot/G1MG27 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. http://togogenome.org/gene/9646:NCBP2 ^@ http://purl.uniprot.org/uniprot/G1LAE9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRM NCBP2 family.|||Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.|||Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.|||Nucleus http://togogenome.org/gene/9646:HAGH ^@ http://purl.uniprot.org/uniprot/G1LPD0 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. http://togogenome.org/gene/9646:ERGIC3 ^@ http://purl.uniprot.org/uniprot/G1LTG4|||http://purl.uniprot.org/uniprot/G1LTG7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/9646:NUF2 ^@ http://purl.uniprot.org/uniprot/G1LIY0 ^@ Similarity ^@ Belongs to the NUF2 family. http://togogenome.org/gene/9646:BTN1A1 ^@ http://purl.uniprot.org/uniprot/G1MC10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Membrane http://togogenome.org/gene/9646:TMEM144 ^@ http://purl.uniprot.org/uniprot/A0A7N5KKQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM144 family.|||Membrane http://togogenome.org/gene/9646:EXO1 ^@ http://purl.uniprot.org/uniprot/D2H9H2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.|||Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Nucleus http://togogenome.org/gene/9646:UCMA ^@ http://purl.uniprot.org/uniprot/G1M4I9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UCMA family.|||May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.|||extracellular matrix http://togogenome.org/gene/9646:SLC66A2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JP48|||http://purl.uniprot.org/uniprot/D2HED4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:CMC1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JYP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion http://togogenome.org/gene/9646:MMS22L ^@ http://purl.uniprot.org/uniprot/G1L705 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MMS22 family. MMS22L subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/9646:ABT1 ^@ http://purl.uniprot.org/uniprot/D2I669 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESF2/ABP1 family.|||nucleolus http://togogenome.org/gene/9646:PPP1R15B ^@ http://purl.uniprot.org/uniprot/D2H8S4 ^@ Similarity ^@ Belongs to the PPP1R15 family. http://togogenome.org/gene/9646:ST3GAL1 ^@ http://purl.uniprot.org/uniprot/D2H3F6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9646:RANBP6 ^@ http://purl.uniprot.org/uniprot/D2I6D4 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9646:HBM ^@ http://purl.uniprot.org/uniprot/D2HDV3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the globin family.|||Heterotetramer of two alpha chains and two beta chains.|||Involved in oxygen transport from the lung to the various peripheral tissues. http://togogenome.org/gene/9646:TLR10 ^@ http://purl.uniprot.org/uniprot/D2HZ64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9646:BUD31 ^@ http://purl.uniprot.org/uniprot/G1LI45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BUD31 (G10) family.|||Nucleus http://togogenome.org/gene/9646:LARS2 ^@ http://purl.uniprot.org/uniprot/D2GV72 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9646:POLD2 ^@ http://purl.uniprot.org/uniprot/D2HNN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase delta/II small subunit family.|||Nucleus http://togogenome.org/gene/9646:LOC100480454 ^@ http://purl.uniprot.org/uniprot/G1LLD0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:GGA1 ^@ http://purl.uniprot.org/uniprot/G1LU21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GGA protein family.|||Early endosome membrane|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9646:SLC31A1 ^@ http://purl.uniprot.org/uniprot/D2H2J4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9646:LOC100478110 ^@ http://purl.uniprot.org/uniprot/D2I0D2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:CIAO2A ^@ http://purl.uniprot.org/uniprot/A0A7N5JZZ8|||http://purl.uniprot.org/uniprot/D2GYR1 ^@ Similarity ^@ Belongs to the MIP18 family. http://togogenome.org/gene/9646:APOC2 ^@ http://purl.uniprot.org/uniprot/D2HPB4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the apolipoprotein C2 family.|||Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase.|||Secreted http://togogenome.org/gene/9646:RPS4X ^@ http://purl.uniprot.org/uniprot/F2X203 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/9646:MGP ^@ http://purl.uniprot.org/uniprot/G1LSP3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.|||Belongs to the osteocalcin/matrix Gla protein family.|||Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.|||Requires vitamin K-dependent gamma-carboxylation for its function.|||Secreted http://togogenome.org/gene/9646:LOC100483811 ^@ http://purl.uniprot.org/uniprot/D2GV81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9646:SUGP1 ^@ http://purl.uniprot.org/uniprot/G1LZG2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:KIF4A ^@ http://purl.uniprot.org/uniprot/D2H8A0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9646:FAM118B ^@ http://purl.uniprot.org/uniprot/A0A7N5JRU3 ^@ Similarity ^@ Belongs to the FAM118 family. http://togogenome.org/gene/9646:JRKL ^@ http://purl.uniprot.org/uniprot/D2HT46 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:NLRP3 ^@ http://purl.uniprot.org/uniprot/D2I5A6 ^@ Similarity ^@ Belongs to the NLRP family. http://togogenome.org/gene/9646:LEPROT ^@ http://purl.uniprot.org/uniprot/A0A7N5JWU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OB-RGRP/VPS55 family.|||Membrane http://togogenome.org/gene/9646:TMCO1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KPJ0|||http://purl.uniprot.org/uniprot/D2GYK7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TMCO1 family.|||Calcium-selective channel required to prevent calcium stores from overfilling.|||Endoplasmic reticulum membrane|||Homodimer and homotetramer. Homodimer under resting conditions; forms homotetramers following and ER calcium overload.|||Membrane http://togogenome.org/gene/9646:GIPC2 ^@ http://purl.uniprot.org/uniprot/D2HJ68 ^@ Similarity ^@ Belongs to the GIPC family. http://togogenome.org/gene/9646:ANAPC13 ^@ http://purl.uniprot.org/uniprot/D2HTF7 ^@ Function|||Similarity ^@ Belongs to the APC13 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. http://togogenome.org/gene/9646:DCTN4 ^@ http://purl.uniprot.org/uniprot/D2H8L3|||http://purl.uniprot.org/uniprot/G1LCZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunit 4 family.|||cell cortex|||centrosome|||sarcomere|||stress fiber http://togogenome.org/gene/9646:DLD ^@ http://purl.uniprot.org/uniprot/G1M5U2 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond.|||acrosome|||flagellum http://togogenome.org/gene/9646:CDC37 ^@ http://purl.uniprot.org/uniprot/G1LYI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC37 family.|||Cytoplasm http://togogenome.org/gene/9646:HNRNPA2B1 ^@ http://purl.uniprot.org/uniprot/A0A7N5P0A5|||http://purl.uniprot.org/uniprot/G1LHD9 ^@ Subcellular Location Annotation ^@ Cytoplasmic granule http://togogenome.org/gene/9646:ABCG4 ^@ http://purl.uniprot.org/uniprot/D2I327 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/9646:FGF5 ^@ http://purl.uniprot.org/uniprot/D2GUG1 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9646:GMFB ^@ http://purl.uniprot.org/uniprot/G1M9Y1 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. GMF subfamily. http://togogenome.org/gene/9646:LSM3 ^@ http://purl.uniprot.org/uniprot/D2CMN7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/9646:CPA5 ^@ http://purl.uniprot.org/uniprot/G1LG08 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9646:POT1 ^@ http://purl.uniprot.org/uniprot/G1M977 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the telombin family.|||Nucleus|||telomere http://togogenome.org/gene/9646:PLOD2 ^@ http://purl.uniprot.org/uniprot/G1M567 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9646:UFM1 ^@ http://purl.uniprot.org/uniprot/G1LG80 ^@ Function|||Similarity ^@ Belongs to the UFM1 family.|||Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. http://togogenome.org/gene/9646:KLHL22 ^@ http://purl.uniprot.org/uniprot/A0A805BFH7 ^@ Subcellular Location Annotation ^@ Lysosome|||Nucleus|||centrosome|||cytosol|||spindle http://togogenome.org/gene/9646:SLC30A4 ^@ http://purl.uniprot.org/uniprot/D2HYJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9646:ADAM9 ^@ http://purl.uniprot.org/uniprot/G1MA96 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:COPG1 ^@ http://purl.uniprot.org/uniprot/G1M9Y5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPG family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/9646:THRSP ^@ http://purl.uniprot.org/uniprot/G1MNK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPOT14 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:SF3B4 ^@ http://purl.uniprot.org/uniprot/D2I4U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3B4 family.|||Nucleus http://togogenome.org/gene/9646:PPARA ^@ http://purl.uniprot.org/uniprot/D2HKK7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.|||Nucleus http://togogenome.org/gene/9646:SLC16A7 ^@ http://purl.uniprot.org/uniprot/D2HND2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/9646:STK38 ^@ http://purl.uniprot.org/uniprot/D2GYV3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9646:MOSPD3 ^@ http://purl.uniprot.org/uniprot/D2HX09 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:CHST11 ^@ http://purl.uniprot.org/uniprot/G1LJJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:TRIQK ^@ http://purl.uniprot.org/uniprot/A0A7N5P2Q1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIQK family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:CDK5R1 ^@ http://purl.uniprot.org/uniprot/D2GU65 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cyclin-dependent kinase 5 activator family.|||Cell membrane|||Heterodimer of a catalytic subunit and a regulatory subunit.|||Membrane http://togogenome.org/gene/9646:C8G ^@ http://purl.uniprot.org/uniprot/G1M3X4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/9646:SSR1 ^@ http://purl.uniprot.org/uniprot/G1MGA8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-alpha family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.|||Membrane|||Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. http://togogenome.org/gene/9646:ERBB3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JLT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/9646:HSBP1 ^@ http://purl.uniprot.org/uniprot/G1LIR8 ^@ Similarity ^@ Belongs to the HSBP1 family. http://togogenome.org/gene/9646:FGB ^@ http://purl.uniprot.org/uniprot/G1MJH9 ^@ Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted http://togogenome.org/gene/9646:CPLX4 ^@ http://purl.uniprot.org/uniprot/D2HQF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9646:SVBP ^@ http://purl.uniprot.org/uniprot/D2I2L3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SVBP family.|||Secreted|||cytoskeleton http://togogenome.org/gene/9646:RRM2B ^@ http://purl.uniprot.org/uniprot/A0A7N5KCG7|||http://purl.uniprot.org/uniprot/G1M8P3 ^@ Cofactor|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase small chain family.|||Binds 2 iron ions per subunit. http://togogenome.org/gene/9646:EPGN ^@ http://purl.uniprot.org/uniprot/G1M6Z4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:KRT79 ^@ http://purl.uniprot.org/uniprot/D2HLN6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9646:PPIL3 ^@ http://purl.uniprot.org/uniprot/G1LH44 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9646:CCN2 ^@ http://purl.uniprot.org/uniprot/D2HL25 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9646:FAM3A ^@ http://purl.uniprot.org/uniprot/G1L0H4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/9646:IPO7 ^@ http://purl.uniprot.org/uniprot/A0A7N5K7M3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:KIFBP ^@ http://purl.uniprot.org/uniprot/D2GXI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KIF-binding protein family.|||cytoskeleton http://togogenome.org/gene/9646:SYNPR ^@ http://purl.uniprot.org/uniprot/A0A7N5KP15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/9646:KCNJ16 ^@ http://purl.uniprot.org/uniprot/D2HP89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9646:ATRX ^@ http://purl.uniprot.org/uniprot/G1L592 ^@ Subcellular Location Annotation ^@ Nucleus|||telomere http://togogenome.org/gene/9646:TNFSF15 ^@ http://purl.uniprot.org/uniprot/D2H2H8 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9646:TSHB ^@ http://purl.uniprot.org/uniprot/D2HS26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/9646:PLA2G1B ^@ http://purl.uniprot.org/uniprot/G1LF10 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9646:TMEM30A ^@ http://purl.uniprot.org/uniprot/D2HSI0 ^@ Similarity ^@ Belongs to the CDC50/LEM3 family. http://togogenome.org/gene/9646:NCAPD2 ^@ http://purl.uniprot.org/uniprot/G1M779 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CND1 (condensin subunit 1) family.|||Chromosome|||Nucleus|||Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. http://togogenome.org/gene/9646:PELI1 ^@ http://purl.uniprot.org/uniprot/G1L2X3 ^@ Function|||Similarity ^@ Belongs to the pellino family.|||E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. http://togogenome.org/gene/9646:FAM131A ^@ http://purl.uniprot.org/uniprot/A0A7N5P646|||http://purl.uniprot.org/uniprot/G1MFB9 ^@ Similarity ^@ Belongs to the FAM131 family. http://togogenome.org/gene/9646:PTER ^@ http://purl.uniprot.org/uniprot/A0A7N5JQI0 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.|||Binds 2 divalent metal cations per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:NUCB2 ^@ http://purl.uniprot.org/uniprot/G1L8F2 ^@ Similarity ^@ Belongs to the nucleobindin family. http://togogenome.org/gene/9646:ERBIN ^@ http://purl.uniprot.org/uniprot/A0A7N5J8F6|||http://purl.uniprot.org/uniprot/A0A7N5JUT5|||http://purl.uniprot.org/uniprot/D2HBQ3|||http://purl.uniprot.org/uniprot/G1LXU9 ^@ Similarity ^@ Belongs to the LAP (LRR and PDZ) protein family. http://togogenome.org/gene/9646:CLEC16A ^@ http://purl.uniprot.org/uniprot/A0A7N5KKW8|||http://purl.uniprot.org/uniprot/A0A7N5KQI6 ^@ Similarity ^@ Belongs to the CLEC16A/gop-1 family. http://togogenome.org/gene/9646:GARS1 ^@ http://purl.uniprot.org/uniprot/G1LJD7 ^@ Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Homodimer. http://togogenome.org/gene/9646:MICOS10 ^@ http://purl.uniprot.org/uniprot/A0A7N5JLY9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic10 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:KIF3A ^@ http://purl.uniprot.org/uniprot/A0A7N5KK87|||http://purl.uniprot.org/uniprot/G1MHB0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9646:TIMM17A ^@ http://purl.uniprot.org/uniprot/G1M008 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9646:KCNA6 ^@ http://purl.uniprot.org/uniprot/D2HEJ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:MAP2K5 ^@ http://purl.uniprot.org/uniprot/A0A7N5KQZ1|||http://purl.uniprot.org/uniprot/G1LEH9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9646:MCM6 ^@ http://purl.uniprot.org/uniprot/D2I516 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/9646:ACSM5 ^@ http://purl.uniprot.org/uniprot/G1LQP4 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9646:APOE ^@ http://purl.uniprot.org/uniprot/D2HPB7 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/9646:NAPSA ^@ http://purl.uniprot.org/uniprot/G1M3R7 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/9646:UGT8 ^@ http://purl.uniprot.org/uniprot/D2I2H6 ^@ Similarity ^@ Belongs to the UDP-glycosyltransferase family. http://togogenome.org/gene/9646:ZMPSTE24 ^@ http://purl.uniprot.org/uniprot/A0A7N5K7V0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48A family.|||Binds 1 zinc ion per subunit.|||Endoplasmic reticulum membrane|||Proteolytically removes the C-terminal three residues of farnesylated proteins. http://togogenome.org/gene/9646:LOC100469119 ^@ http://purl.uniprot.org/uniprot/A0A7N5JV67 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9646:GMDS ^@ http://purl.uniprot.org/uniprot/G1LWN5 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. http://togogenome.org/gene/9646:FGD3 ^@ http://purl.uniprot.org/uniprot/D2HXA5 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9646:LOC100465520 ^@ http://purl.uniprot.org/uniprot/D2HML1 ^@ Similarity ^@ Belongs to the Schlafen family. Subgroup III subfamily. http://togogenome.org/gene/9646:BOLA1 ^@ http://purl.uniprot.org/uniprot/D2I4V0 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/9646:SLC25A53 ^@ http://purl.uniprot.org/uniprot/G1MKP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9646:GPSM2 ^@ http://purl.uniprot.org/uniprot/A0A7N5K3X3 ^@ Similarity ^@ Belongs to the GPSM family. http://togogenome.org/gene/9646:MLLT11 ^@ http://purl.uniprot.org/uniprot/D2HBT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MLLT11 family.|||Nucleus|||centrosome http://togogenome.org/gene/9646:THOC5 ^@ http://purl.uniprot.org/uniprot/A0A7N5P252|||http://purl.uniprot.org/uniprot/G1LNK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the THOC5 family.|||Nucleus http://togogenome.org/gene/9646:SEC13 ^@ http://purl.uniprot.org/uniprot/G1MC17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||Lysosome membrane http://togogenome.org/gene/9646:FBXO9 ^@ http://purl.uniprot.org/uniprot/G1LGL8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2.|||Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1. Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway. Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation. http://togogenome.org/gene/9646:STX19 ^@ http://purl.uniprot.org/uniprot/A0A7N5KTB2 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9646:GLUL ^@ http://purl.uniprot.org/uniprot/D2HBW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamine synthetase family.|||Cell membrane|||Membrane|||Microsome|||Mitochondrion http://togogenome.org/gene/9646:GCDH ^@ http://purl.uniprot.org/uniprot/G1M176 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9646:LMOD3 ^@ http://purl.uniprot.org/uniprot/G1LU65 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9646:MGME1 ^@ http://purl.uniprot.org/uniprot/G1LF86 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGME1 family.|||Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair.|||Mitochondrion http://togogenome.org/gene/9646:TGFA ^@ http://purl.uniprot.org/uniprot/G1MBZ9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:TTC4 ^@ http://purl.uniprot.org/uniprot/A0A7N5JPP0|||http://purl.uniprot.org/uniprot/G1LTM9 ^@ Similarity ^@ Belongs to the TTC4 family. http://togogenome.org/gene/9646:LOC100482335 ^@ http://purl.uniprot.org/uniprot/G1L0I9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9646:PSMA1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JM49 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9646:LOC100481510 ^@ http://purl.uniprot.org/uniprot/D2HIV3 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the copper/topaquinone oxidase family.|||Contains 1 topaquinone per subunit.|||Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. http://togogenome.org/gene/9646:CPLX2 ^@ http://purl.uniprot.org/uniprot/D2HHT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9646:SRRD ^@ http://purl.uniprot.org/uniprot/G1MIB3 ^@ Similarity ^@ Belongs to the SRR1 family. http://togogenome.org/gene/9646:RPL24 ^@ http://purl.uniprot.org/uniprot/F2X267 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/9646:TMEM167A ^@ http://purl.uniprot.org/uniprot/A0A7N5KGT2|||http://purl.uniprot.org/uniprot/A0A7N5KRX1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KISH family.|||Golgi apparatus membrane|||Involved in the early part of the secretory pathway.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:ARHGAP36 ^@ http://purl.uniprot.org/uniprot/D2H9U0 ^@ Function ^@ GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. http://togogenome.org/gene/9646:CDC26 ^@ http://purl.uniprot.org/uniprot/D2H2J3 ^@ Function|||Similarity ^@ Belongs to the CDC26 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. http://togogenome.org/gene/9646:TXNRD1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KCL9 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/9646:CMKLR1 ^@ http://purl.uniprot.org/uniprot/G1MKF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:SNX19 ^@ http://purl.uniprot.org/uniprot/G1L5F4 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9646:TRAF3 ^@ http://purl.uniprot.org/uniprot/D2HAH0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:ST3GAL6 ^@ http://purl.uniprot.org/uniprot/D2HSL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9646:GALNTL5 ^@ http://purl.uniprot.org/uniprot/G1M431 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Membrane http://togogenome.org/gene/9646:FBXO32 ^@ http://purl.uniprot.org/uniprot/D2HPI0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:ACVRL1 ^@ http://purl.uniprot.org/uniprot/G1L4X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9646:SYT1 ^@ http://purl.uniprot.org/uniprot/D2H516 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.|||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.|||synaptic vesicle membrane http://togogenome.org/gene/9646:KEG54_p11 ^@ http://purl.uniprot.org/uniprot/A5JFJ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9646:LOC100477562 ^@ http://purl.uniprot.org/uniprot/D2H9P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9646:MAN1C1 ^@ http://purl.uniprot.org/uniprot/G1LUP7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9646:SPATS2L ^@ http://purl.uniprot.org/uniprot/A0A7N5JTB2 ^@ Similarity ^@ Belongs to the SPATS2 family. http://togogenome.org/gene/9646:HNRNPR ^@ http://purl.uniprot.org/uniprot/D2GWC0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:SFXN5 ^@ http://purl.uniprot.org/uniprot/G1MAU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9646:EIF3E ^@ http://purl.uniprot.org/uniprot/G1M2D6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit E family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with COPS3, COPS6, COPS7 (COPS7A or COPS7B), EIF4G1, EPAS1, MCM7, NCBP1, PSMC6, TRIM27 and UPF2.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.|||Cytoplasm|||Nucleus|||PML body|||Phosphorylated upon DNA damage, probably by ATM or ATR. http://togogenome.org/gene/9646:PPP1CB ^@ http://purl.uniprot.org/uniprot/G1LEU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family. PP-1 subfamily.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9646:MAPK13 ^@ http://purl.uniprot.org/uniprot/G1L0N5 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Interacts with MAPK8IP2. http://togogenome.org/gene/9646:KATNAL1 ^@ http://purl.uniprot.org/uniprot/G1LQL6 ^@ Activity Regulation|||Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.|||Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.|||Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.|||Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.|||Cytoplasm|||Interacts with KATNB1 and KATNBL1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Midbody|||Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.|||Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.|||The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.|||Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.|||centrosome|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/9646:MTMR3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JQV3|||http://purl.uniprot.org/uniprot/A0A7N5KBA9|||http://purl.uniprot.org/uniprot/A0A7N5P226 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/9646:GRHL2 ^@ http://purl.uniprot.org/uniprot/A0A7N5KIJ5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:ZPR1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JEE9|||http://purl.uniprot.org/uniprot/D2HC81 ^@ Similarity ^@ Belongs to the ZPR1 family. http://togogenome.org/gene/9646:DDOST ^@ http://purl.uniprot.org/uniprot/G1L8D0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DDOST 48 kDa subunit family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). http://togogenome.org/gene/9646:OLFM3 ^@ http://purl.uniprot.org/uniprot/A0A7N5P3F9|||http://purl.uniprot.org/uniprot/D2HAQ5 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/9646:PDCL ^@ http://purl.uniprot.org/uniprot/D2I6X7 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9646:IFNL3 ^@ http://purl.uniprot.org/uniprot/D2HX83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lambda interferon family.|||Secreted http://togogenome.org/gene/9646:VPS53 ^@ http://purl.uniprot.org/uniprot/G1LNV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS53 family.|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9646:LOC100473356 ^@ http://purl.uniprot.org/uniprot/A0A7N5K682 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX16 family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9646:PPEF1 ^@ http://purl.uniprot.org/uniprot/G1MEI5 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/9646:SV2A ^@ http://purl.uniprot.org/uniprot/D2I4U9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/9646:MCTS1 ^@ http://purl.uniprot.org/uniprot/A0A7N5P0Z3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCTS1 family.|||Cytoplasm http://togogenome.org/gene/9646:CDR2 ^@ http://purl.uniprot.org/uniprot/D2HTZ8 ^@ Similarity ^@ Belongs to the CDR2 family. http://togogenome.org/gene/9646:RUNX1T1 ^@ http://purl.uniprot.org/uniprot/A0A7N5P2T3|||http://purl.uniprot.org/uniprot/G1LKJ2|||http://purl.uniprot.org/uniprot/G1LKK1 ^@ Similarity ^@ Belongs to the CBFA2T family. http://togogenome.org/gene/9646:TSPAN5 ^@ http://purl.uniprot.org/uniprot/G1M5J3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9646:PIH1D1 ^@ http://purl.uniprot.org/uniprot/G1M694 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/9646:MMP16 ^@ http://purl.uniprot.org/uniprot/G1MFI5 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9646:DHPS ^@ http://purl.uniprot.org/uniprot/D2HG03 ^@ Similarity ^@ Belongs to the deoxyhypusine synthase family. http://togogenome.org/gene/9646:DPM3 ^@ http://purl.uniprot.org/uniprot/G1MKK3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPM3 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER. http://togogenome.org/gene/9646:P2RX3 ^@ http://purl.uniprot.org/uniprot/D2HK57 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P2X receptor family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9646:CAV2 ^@ http://purl.uniprot.org/uniprot/D2H6R7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||caveola http://togogenome.org/gene/9646:GORAB ^@ http://purl.uniprot.org/uniprot/G1LX89 ^@ Similarity ^@ Belongs to the GORAB family. http://togogenome.org/gene/9646:THRB ^@ http://purl.uniprot.org/uniprot/D2HYY1|||http://purl.uniprot.org/uniprot/G1MI06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9646:CCR4 ^@ http://purl.uniprot.org/uniprot/D2HB03 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:LOC100483803 ^@ http://purl.uniprot.org/uniprot/A0A7N5KLS1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:UBR1 ^@ http://purl.uniprot.org/uniprot/G1MB21 ^@ Function|||Similarity ^@ Belongs to the UBR1 family.|||Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. http://togogenome.org/gene/9646:LBX2 ^@ http://purl.uniprot.org/uniprot/G1MFQ6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:B3GNT5 ^@ http://purl.uniprot.org/uniprot/G1MNJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:LIPT1 ^@ http://purl.uniprot.org/uniprot/D2HDD0 ^@ Similarity ^@ Belongs to the LplA family. http://togogenome.org/gene/9646:EPHA3 ^@ http://purl.uniprot.org/uniprot/G1LPI5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:MMP9 ^@ http://purl.uniprot.org/uniprot/D2HZ16 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||extracellular matrix http://togogenome.org/gene/9646:ABCG2 ^@ http://purl.uniprot.org/uniprot/A0A7N5K0F8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/9646:LOC100470062 ^@ http://purl.uniprot.org/uniprot/A0A7N5JAT8 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9646:NELFE ^@ http://purl.uniprot.org/uniprot/A0A7N5JZ74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM NELF-E family.|||Chromosome|||Nucleus http://togogenome.org/gene/9646:LOC100475526 ^@ http://purl.uniprot.org/uniprot/A0A7N5JHP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase VIIb family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9646:TUBG1 ^@ http://purl.uniprot.org/uniprot/D2HIU3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin family.|||Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.|||centrosome http://togogenome.org/gene/9646:CUEDC2 ^@ http://purl.uniprot.org/uniprot/D2GXW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUEDC2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:AADAC ^@ http://purl.uniprot.org/uniprot/D2H403 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/9646:MC3R ^@ http://purl.uniprot.org/uniprot/G1MMD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane http://togogenome.org/gene/9646:RAMAC ^@ http://purl.uniprot.org/uniprot/D2I4M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAM family.|||Nucleus http://togogenome.org/gene/9646:ZKSCAN5 ^@ http://purl.uniprot.org/uniprot/A0A7N5JPY3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:CLDN19 ^@ http://purl.uniprot.org/uniprot/D2I2L6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9646:RNF103 ^@ http://purl.uniprot.org/uniprot/G1LTS2 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9646:TWSG1 ^@ http://purl.uniprot.org/uniprot/D2H764 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the twisted gastrulation protein family.|||Secreted http://togogenome.org/gene/9646:OGFOD1 ^@ http://purl.uniprot.org/uniprot/D2GTV6 ^@ Similarity ^@ Belongs to the TPA1 family. http://togogenome.org/gene/9646:STK17B ^@ http://purl.uniprot.org/uniprot/D2H630 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9646:TIMM10 ^@ http://purl.uniprot.org/uniprot/D2CMN8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9646:C14H18orf21 ^@ http://purl.uniprot.org/uniprot/D2HQD3 ^@ Similarity ^@ Belongs to the UPF0711 family. http://togogenome.org/gene/9646:STMN1 ^@ http://purl.uniprot.org/uniprot/G1LUS1 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/9646:SLC7A2 ^@ http://purl.uniprot.org/uniprot/G1M538 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:GCNT4 ^@ http://purl.uniprot.org/uniprot/D2H684 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:CD40LG ^@ http://purl.uniprot.org/uniprot/D2HD93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.|||Belongs to the tumor necrosis factor family.|||Cell surface http://togogenome.org/gene/9646:LOC100483558 ^@ http://purl.uniprot.org/uniprot/D2I7H0 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9646:CAT ^@ http://purl.uniprot.org/uniprot/G1LN56 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the catalase family.|||Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.|||Peroxisome http://togogenome.org/gene/9646:OCLN ^@ http://purl.uniprot.org/uniprot/G1L979 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Cell membrane|||May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.|||Membrane|||tight junction http://togogenome.org/gene/9646:OGN ^@ http://purl.uniprot.org/uniprot/G1M4F9 ^@ Similarity ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. http://togogenome.org/gene/9646:ELP2 ^@ http://purl.uniprot.org/uniprot/D2HQD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat ELP2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:CFAP94 ^@ http://purl.uniprot.org/uniprot/A0A7N5KG46|||http://purl.uniprot.org/uniprot/A0A7N5KT02 ^@ Similarity ^@ Belongs to the DNAI7 family. http://togogenome.org/gene/9646:SSBP2 ^@ http://purl.uniprot.org/uniprot/A0A7N5P6Q4|||http://purl.uniprot.org/uniprot/G1MBU9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:RFFL ^@ http://purl.uniprot.org/uniprot/D2HMK7 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9646:HOXA9 ^@ http://purl.uniprot.org/uniprot/D2GVB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9646:LOC100464338 ^@ http://purl.uniprot.org/uniprot/D2HI71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:PNPLA4 ^@ http://purl.uniprot.org/uniprot/D2I355 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:TNFSF14 ^@ http://purl.uniprot.org/uniprot/D2HY81 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9646:CHD7 ^@ http://purl.uniprot.org/uniprot/D2H2C4 ^@ Similarity ^@ Belongs to the SNF2/RAD54 helicase family. http://togogenome.org/gene/9646:KCNAB1 ^@ http://purl.uniprot.org/uniprot/G1L8W5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shaker potassium channel beta subunit family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9646:GNB3 ^@ http://purl.uniprot.org/uniprot/G1M605 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/9646:C1D ^@ http://purl.uniprot.org/uniprot/G1LDZ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the C1D family.|||Cytoplasm|||Monomer and homodimer.|||Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.|||nucleolus http://togogenome.org/gene/9646:TMEM237 ^@ http://purl.uniprot.org/uniprot/G1M4A0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM237 family.|||Component of the transition zone in primary cilia. Required for ciliogenesis.|||Membrane|||cilium http://togogenome.org/gene/9646:POLR2M ^@ http://purl.uniprot.org/uniprot/G1LVI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRINL1 family.|||Nucleus http://togogenome.org/gene/9646:GSX2 ^@ http://purl.uniprot.org/uniprot/D2HBV5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:LYRM2 ^@ http://purl.uniprot.org/uniprot/G1L149 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9646:CDNF ^@ http://purl.uniprot.org/uniprot/D2I3V4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARMET family.|||Secreted http://togogenome.org/gene/9646:PAM16 ^@ http://purl.uniprot.org/uniprot/A0A7N5JMS5 ^@ Similarity ^@ Belongs to the TIM16/PAM16 family. http://togogenome.org/gene/9646:USE1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JFZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the USE1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:PVALB ^@ http://purl.uniprot.org/uniprot/G1LT07 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/9646:GPN2 ^@ http://purl.uniprot.org/uniprot/A0A7N5KHJ4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/9646:LOC100466453 ^@ http://purl.uniprot.org/uniprot/D2I678 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:ATP6V1B2 ^@ http://purl.uniprot.org/uniprot/D2I2A2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the ATPase alpha/beta chains family.|||Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits. http://togogenome.org/gene/9646:ENTPD4 ^@ http://purl.uniprot.org/uniprot/G1L833 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9646:NCL ^@ http://purl.uniprot.org/uniprot/G1MD31 ^@ Function|||Subcellular Location Annotation ^@ Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.|||nucleolus http://togogenome.org/gene/9646:FTL ^@ http://purl.uniprot.org/uniprot/D2H7X8 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/9646:DDX59 ^@ http://purl.uniprot.org/uniprot/D2GZP4 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX59 subfamily. http://togogenome.org/gene/9646:HSPB3 ^@ http://purl.uniprot.org/uniprot/D2HXE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:FAM98C ^@ http://purl.uniprot.org/uniprot/D2HTH2 ^@ Similarity ^@ Belongs to the FAM98 family. http://togogenome.org/gene/9646:JPT1 ^@ http://purl.uniprot.org/uniprot/G1LRG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:ILDR1 ^@ http://purl.uniprot.org/uniprot/G1M6Q3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. LISCH7 family.|||Membrane|||tight junction http://togogenome.org/gene/9646:HNF1B ^@ http://purl.uniprot.org/uniprot/A0A7N5K4F9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HNF1 homeobox family.|||Nucleus http://togogenome.org/gene/9646:LOC100475355 ^@ http://purl.uniprot.org/uniprot/A0A7N5JG13 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:CCT8 ^@ http://purl.uniprot.org/uniprot/A0A7N5JFQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||cilium basal body http://togogenome.org/gene/9646:PICALM ^@ http://purl.uniprot.org/uniprot/A0A7N5J857|||http://purl.uniprot.org/uniprot/A0A7N5KG26|||http://purl.uniprot.org/uniprot/A0A7N5KGZ1|||http://purl.uniprot.org/uniprot/A0A7N5KSW6|||http://purl.uniprot.org/uniprot/G1LQC0 ^@ Similarity ^@ Belongs to the PICALM/SNAP91 family. http://togogenome.org/gene/9646:LOC100482027 ^@ http://purl.uniprot.org/uniprot/A0A7N5KH24 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9646:RPL28 ^@ http://purl.uniprot.org/uniprot/D2HUW2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL28 family. http://togogenome.org/gene/9646:SMPD2 ^@ http://purl.uniprot.org/uniprot/D2HT00 ^@ Similarity ^@ Belongs to the neutral sphingomyelinase family. http://togogenome.org/gene/9646:NTRK3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JW29|||http://purl.uniprot.org/uniprot/A0A7N5KDU3|||http://purl.uniprot.org/uniprot/G1M275 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:RXRB ^@ http://purl.uniprot.org/uniprot/D2GZ06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Nucleus http://togogenome.org/gene/9646:AMIGO1 ^@ http://purl.uniprot.org/uniprot/D2HBH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. AMIGO family.|||Membrane http://togogenome.org/gene/9646:LOC100471731 ^@ http://purl.uniprot.org/uniprot/D2I6T5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:CPSF6 ^@ http://purl.uniprot.org/uniprot/G1LZA1|||http://purl.uniprot.org/uniprot/G1LZA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM CPSF6/7 family.|||Nucleus http://togogenome.org/gene/9646:MSH4 ^@ http://purl.uniprot.org/uniprot/G1LAB4 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutS family. http://togogenome.org/gene/9646:SLC35E4 ^@ http://purl.uniprot.org/uniprot/D2H215 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:TMEM161A ^@ http://purl.uniprot.org/uniprot/G1LYX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM161 family.|||Membrane http://togogenome.org/gene/9646:KEG54_p10 ^@ http://purl.uniprot.org/uniprot/A0A1I9WA83|||http://purl.uniprot.org/uniprot/Q2Y0B9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Binds a copper A center.|||Binds a dinuclear copper A center per subunit.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2. Interacts with TMEM177 in a COX20-dependent manner. Interacts with COX20. Interacts with COX16 (By similarity).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9646:RASGRP3 ^@ http://purl.uniprot.org/uniprot/G1LMK1 ^@ Similarity ^@ Belongs to the RASGRP family. http://togogenome.org/gene/9646:ARPC1A ^@ http://purl.uniprot.org/uniprot/G1LI97 ^@ Function|||Similarity ^@ Belongs to the WD repeat ARPC1 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. http://togogenome.org/gene/9646:EXOC4 ^@ http://purl.uniprot.org/uniprot/G1MEJ2 ^@ Function|||Similarity ^@ Belongs to the SEC8 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/9646:LOC100477935 ^@ http://purl.uniprot.org/uniprot/D2HZE9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:NAPA ^@ http://purl.uniprot.org/uniprot/G1LND3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/9646:GFRA2 ^@ http://purl.uniprot.org/uniprot/G1LAJ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GDNFR family.|||Cell membrane|||Membrane|||Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. http://togogenome.org/gene/9646:IL6ST ^@ http://purl.uniprot.org/uniprot/G1LAB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/9646:SERINC3 ^@ http://purl.uniprot.org/uniprot/G1LBG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9646:NTS ^@ http://purl.uniprot.org/uniprot/A0A7N5KHN0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurotensin family.|||Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.|||Secreted|||Vesicle|||secretory vesicle http://togogenome.org/gene/9646:TADA2A ^@ http://purl.uniprot.org/uniprot/G1M3Q5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:SMC3 ^@ http://purl.uniprot.org/uniprot/G1MB71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC3 subfamily.|||Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.|||Nucleus|||centromere http://togogenome.org/gene/9646:LOC100467415 ^@ http://purl.uniprot.org/uniprot/D2HED0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:LOC100475793 ^@ http://purl.uniprot.org/uniprot/A0A7N5PAE7|||http://purl.uniprot.org/uniprot/G1M1D5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/9646:LOC109490354 ^@ http://purl.uniprot.org/uniprot/G1MLE5 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/9646:SLC25A30 ^@ http://purl.uniprot.org/uniprot/A0A7N5JTH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9646:PGK2 ^@ http://purl.uniprot.org/uniprot/D2H1P3 ^@ Similarity|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Monomer. http://togogenome.org/gene/9646:CNOT8 ^@ http://purl.uniprot.org/uniprot/D2H634 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/9646:ELMO1 ^@ http://purl.uniprot.org/uniprot/G1MII8 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. http://togogenome.org/gene/9646:NIM1K ^@ http://purl.uniprot.org/uniprot/D2HHQ9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9646:PSMD11 ^@ http://purl.uniprot.org/uniprot/D2GU64 ^@ Similarity ^@ Belongs to the proteasome subunit S9 family. http://togogenome.org/gene/9646:IFT57 ^@ http://purl.uniprot.org/uniprot/D2HVA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFT57 family.|||cilium basal body http://togogenome.org/gene/9646:TLX2 ^@ http://purl.uniprot.org/uniprot/D2HH56 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:PGD ^@ http://purl.uniprot.org/uniprot/G1LJK1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the 6-phosphogluconate dehydrogenase family.|||Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.|||Homodimer. http://togogenome.org/gene/9646:MRPL32 ^@ http://purl.uniprot.org/uniprot/D2HM12 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/9646:ABCB8 ^@ http://purl.uniprot.org/uniprot/A0A7N5JBM3|||http://purl.uniprot.org/uniprot/G1M5L5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:RPS24 ^@ http://purl.uniprot.org/uniprot/A0A7N5JML7|||http://purl.uniprot.org/uniprot/A0A7N5JQF2|||http://purl.uniprot.org/uniprot/A0A7N5KJX1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/9646:AIDA ^@ http://purl.uniprot.org/uniprot/D2GYL3 ^@ Similarity ^@ Belongs to the AIDA family. http://togogenome.org/gene/9646:MYLK2 ^@ http://purl.uniprot.org/uniprot/G1M4Y3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.|||Cytoplasm|||May interact with centrin. http://togogenome.org/gene/9646:PHKG2 ^@ http://purl.uniprot.org/uniprot/D2HQN8 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily.|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin. http://togogenome.org/gene/9646:ANXA7 ^@ http://purl.uniprot.org/uniprot/G1MEU2|||http://purl.uniprot.org/uniprot/G1MEU5 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9646:PKIA ^@ http://purl.uniprot.org/uniprot/A0A7N5KHH1 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/9646:RHPN2 ^@ http://purl.uniprot.org/uniprot/G1MAP5 ^@ Similarity ^@ Belongs to the RHPN family. http://togogenome.org/gene/9646:ATF1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KGL8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:RPS20 ^@ http://purl.uniprot.org/uniprot/E4W6Z3 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Component of the 40S small ribosomal subunit. http://togogenome.org/gene/9646:CLEC12B ^@ http://purl.uniprot.org/uniprot/D2HS34 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9646:MRPL4 ^@ http://purl.uniprot.org/uniprot/D2HGZ5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL4 family. http://togogenome.org/gene/9646:SNX5 ^@ http://purl.uniprot.org/uniprot/G1LFA9 ^@ Function|||Similarity ^@ Belongs to the sorting nexin family.|||Involved in several stages of intracellular trafficking. http://togogenome.org/gene/9646:MRPS9 ^@ http://purl.uniprot.org/uniprot/D2GWY2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/9646:AQP4 ^@ http://purl.uniprot.org/uniprot/G1M6L3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:NAGK ^@ http://purl.uniprot.org/uniprot/G1MBI6 ^@ Similarity ^@ Belongs to the eukaryotic-type N-acetylglucosamine kinase family. http://togogenome.org/gene/9646:CDCA2 ^@ http://purl.uniprot.org/uniprot/D2GZ78 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:CADM4 ^@ http://purl.uniprot.org/uniprot/G1LC94 ^@ Similarity ^@ Belongs to the nectin family. http://togogenome.org/gene/9646:LOC100466776 ^@ http://purl.uniprot.org/uniprot/G1LGC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Membrane http://togogenome.org/gene/9646:RRAGD ^@ http://purl.uniprot.org/uniprot/G1L106 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/9646:HSDL1 ^@ http://purl.uniprot.org/uniprot/D2HRI3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9646:PLA2G4F ^@ http://purl.uniprot.org/uniprot/G1MCX9 ^@ Domain|||Subcellular Location Annotation ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding.|||cytosol http://togogenome.org/gene/9646:GAMT ^@ http://purl.uniprot.org/uniprot/G1L9G0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.|||Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor.|||Monomer. http://togogenome.org/gene/9646:KIN ^@ http://purl.uniprot.org/uniprot/G1LTR1 ^@ Similarity ^@ Belongs to the KIN17 family. http://togogenome.org/gene/9646:INO80D ^@ http://purl.uniprot.org/uniprot/A0A7N5JD86 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:TAF6 ^@ http://purl.uniprot.org/uniprot/D2I5E6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF6 family.|||Nucleus http://togogenome.org/gene/9646:LOC100465033 ^@ http://purl.uniprot.org/uniprot/D2I0N1 ^@ Similarity ^@ Belongs to the PRR23 family. http://togogenome.org/gene/9646:GPER1 ^@ http://purl.uniprot.org/uniprot/G1MP46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:MID2 ^@ http://purl.uniprot.org/uniprot/G1L7V9 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9646:LOC100467386 ^@ http://purl.uniprot.org/uniprot/D2I7P2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:MRPL44 ^@ http://purl.uniprot.org/uniprot/D2H9R3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.|||Mitochondrion http://togogenome.org/gene/9646:ACTRT3 ^@ http://purl.uniprot.org/uniprot/D2H6S0 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9646:TXNL4A ^@ http://purl.uniprot.org/uniprot/D2HED5 ^@ Similarity ^@ Belongs to the DIM1 family. http://togogenome.org/gene/9646:SLC26A9 ^@ http://purl.uniprot.org/uniprot/A0A7N5KDC6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Ion transporter that can act both as an ion channel and anion exchanger. Mainly acts as a chloride channel, which mediate uncoupled chloride anion transport in an alternate-access mechanism where a saturable binding site is alternately exposed to either one or the other side of the membrane. Also acts as a DIDS- and thiosulfate- sensitive anion exchanger the exchange of chloride for bicarbonate ions across the cell membrane.|||Membrane http://togogenome.org/gene/9646:SPIB ^@ http://purl.uniprot.org/uniprot/A0A7N5JZ84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9646:DPAGT1 ^@ http://purl.uniprot.org/uniprot/D2I329 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family.|||Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:PEX5 ^@ http://purl.uniprot.org/uniprot/D2HIZ3 ^@ Similarity ^@ Belongs to the peroxisomal targeting signal receptor family. http://togogenome.org/gene/9646:UROS ^@ http://purl.uniprot.org/uniprot/D2H3F0 ^@ Similarity ^@ Belongs to the uroporphyrinogen-III synthase family. http://togogenome.org/gene/9646:HPDL ^@ http://purl.uniprot.org/uniprot/D2HC33 ^@ Cofactor|||Similarity ^@ Belongs to the 4HPPD family.|||Binds 1 Fe cation per subunit. http://togogenome.org/gene/9646:CXCR4 ^@ http://purl.uniprot.org/uniprot/G1MLH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell junction|||Cell membrane|||Early endosome|||Endosome|||Late endosome|||Lysosome|||Membrane http://togogenome.org/gene/9646:VCL ^@ http://purl.uniprot.org/uniprot/D2HEE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.|||Belongs to the vinculin/alpha-catenin family.|||Cell membrane|||Membrane|||adherens junction|||podosome http://togogenome.org/gene/9646:CLCC1 ^@ http://purl.uniprot.org/uniprot/D2HBG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel MCLC family.|||Membrane http://togogenome.org/gene/9646:PCNA ^@ http://purl.uniprot.org/uniprot/D2HQS7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PCNA family.|||Nucleus|||This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. http://togogenome.org/gene/9646:C4H2orf68 ^@ http://purl.uniprot.org/uniprot/D2HKM8 ^@ Similarity ^@ Belongs to the UPF0561 family. http://togogenome.org/gene/9646:BTF3L4 ^@ http://purl.uniprot.org/uniprot/G1LRE7 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/9646:INTS9 ^@ http://purl.uniprot.org/uniprot/A0A7N5JW83|||http://purl.uniprot.org/uniprot/G1MC36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.|||Nucleus http://togogenome.org/gene/9646:TRIM32 ^@ http://purl.uniprot.org/uniprot/G1MMT5 ^@ Similarity ^@ Belongs to the TRIM/RBCC family. http://togogenome.org/gene/9646:CNTF ^@ http://purl.uniprot.org/uniprot/D2HZE5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNTF family.|||CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.|||Cytoplasm http://togogenome.org/gene/9646:PKP2 ^@ http://purl.uniprot.org/uniprot/A0A7N5K6Q7 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/9646:CLTA ^@ http://purl.uniprot.org/uniprot/G1LTW2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin light chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||coated pit http://togogenome.org/gene/9646:FMO4 ^@ http://purl.uniprot.org/uniprot/D2I020 ^@ Similarity ^@ Belongs to the FMO family. http://togogenome.org/gene/9646:KCNMB4 ^@ http://purl.uniprot.org/uniprot/D2HIW6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KCNMB (TC 8.A.14.1) family.|||Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.|||Membrane|||N-glycosylated.|||Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. http://togogenome.org/gene/9646:CRKL ^@ http://purl.uniprot.org/uniprot/D2HUK7 ^@ Similarity ^@ Belongs to the CRK family. http://togogenome.org/gene/9646:TET2 ^@ http://purl.uniprot.org/uniprot/G1LJZ8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TET family.|||Binds 1 Fe(2+) ion per subunit.|||Chromosome|||Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.|||The zinc ions have a structural role. http://togogenome.org/gene/9646:FAM221A ^@ http://purl.uniprot.org/uniprot/A0A7N5J8I0 ^@ Similarity ^@ Belongs to the FAM221 family. http://togogenome.org/gene/9646:ACLY ^@ http://purl.uniprot.org/uniprot/G1LGZ5 ^@ Function|||Similarity|||Subunit ^@ Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.|||Homotetramer.|||In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.|||In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. http://togogenome.org/gene/9646:ASPHD1 ^@ http://purl.uniprot.org/uniprot/G1M913 ^@ Similarity ^@ Belongs to the aspartyl/asparaginyl beta-hydroxylase family. http://togogenome.org/gene/9646:SULT2B1 ^@ http://purl.uniprot.org/uniprot/G1M8P2 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9646:EDC3 ^@ http://purl.uniprot.org/uniprot/D2HKY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EDC3 family.|||P-body http://togogenome.org/gene/9646:NDUFS5 ^@ http://purl.uniprot.org/uniprot/D2HXG9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS5 subunit family.|||Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9646:CD3E ^@ http://purl.uniprot.org/uniprot/G1M3G6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9646:SCG5 ^@ http://purl.uniprot.org/uniprot/D2H7R3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.|||Belongs to the 7B2 family.|||Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.|||Secreted http://togogenome.org/gene/9646:NBN ^@ http://purl.uniprot.org/uniprot/G1M943 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.|||Component of the MRN complex.|||Nucleus|||telomere http://togogenome.org/gene/9646:HOXC11 ^@ http://purl.uniprot.org/uniprot/D2HM43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9646:URM1 ^@ http://purl.uniprot.org/uniprot/G1MAC0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.|||Belongs to the URM1 family.|||C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.|||Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.|||Cytoplasm http://togogenome.org/gene/9646:PUS3 ^@ http://purl.uniprot.org/uniprot/G1KZV9 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/9646:ATP6V0A4 ^@ http://purl.uniprot.org/uniprot/D2GYN5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/9646:PTGR2 ^@ http://purl.uniprot.org/uniprot/G1MIT3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADP-dependent oxidoreductase L4BD family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9646:PSMA2 ^@ http://purl.uniprot.org/uniprot/G1LS94 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9646:MSTN ^@ http://purl.uniprot.org/uniprot/D2HA19 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts specifically as a negative regulator of skeletal muscle growth.|||Belongs to the TGF-beta family.|||Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FSTL3.|||Secreted http://togogenome.org/gene/9646:ADCK1 ^@ http://purl.uniprot.org/uniprot/A0A7N5P0N8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family.|||Secreted http://togogenome.org/gene/9646:C4H19orf53 ^@ http://purl.uniprot.org/uniprot/D2HFY2 ^@ Function|||Similarity ^@ Belongs to the UPF0390 family.|||May have a potential role in hypercalcemia of malignancy. http://togogenome.org/gene/9646:LEAP2 ^@ http://purl.uniprot.org/uniprot/G1MHC4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LEAP2 family.|||Has an antimicrobial activity.|||Secreted http://togogenome.org/gene/9646:LOC109491003 ^@ http://purl.uniprot.org/uniprot/A0A7N5KC20 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:SSR4 ^@ http://purl.uniprot.org/uniprot/G1MJI4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-delta family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/9646:ATP10D ^@ http://purl.uniprot.org/uniprot/D2H5N9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9646:BRCC3 ^@ http://purl.uniprot.org/uniprot/G1LZT1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M67A family. BRCC36 subfamily.|||Binds 1 zinc ion per subunit.|||Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1 and BABAM2. Component of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Identified in a complex with SHMT2 and the other subunits of the BRISC complex. In the BRISC complex, interacts directly with ABRAXAS2. Identified in a complex with ABRAXAS2 and NUMA1. The BRISC complex interacts with the CSN complex. Component of the BRCA1/BRCA2 containing complex (BRCC), which also contains BRCA1, BRCA2, BARD1, BABAM2 and RAD51. BRCC is a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage. Interacts with BRCA1. Binds polyubiquitin. Interacts with PWWP2B. Interacts with HDAC1; this interaction is enhanced in the presence of PWWP2B.|||Cytoplasm|||Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.|||Nucleus|||spindle pole http://togogenome.org/gene/9646:AKT3 ^@ http://purl.uniprot.org/uniprot/G1LRV9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. http://togogenome.org/gene/9646:ZFPL1 ^@ http://purl.uniprot.org/uniprot/G1MH70 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ZFPL1 family.|||Interacts with GOLGA2/GM130.|||Membrane|||Required for cis-Golgi integrity and efficient ER to Golgi transport.|||The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.|||cis-Golgi network membrane http://togogenome.org/gene/9646:LOC100477520 ^@ http://purl.uniprot.org/uniprot/D2I7L5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:CCL21 ^@ http://purl.uniprot.org/uniprot/A0A7N5JAC2 ^@ Similarity ^@ Belongs to the intercrine beta (chemokine CC) family. http://togogenome.org/gene/9646:S1PR3 ^@ http://purl.uniprot.org/uniprot/G1MNK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:VKORC1 ^@ http://purl.uniprot.org/uniprot/D2HQM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VKOR family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:EXOSC3 ^@ http://purl.uniprot.org/uniprot/D2H0I3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP40 family.|||Cytoplasm|||nucleolus http://togogenome.org/gene/9646:NR5A2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JJM9|||http://purl.uniprot.org/uniprot/G1M1X4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR5 subfamily.|||Nucleus http://togogenome.org/gene/9646:UTS2B ^@ http://purl.uniprot.org/uniprot/G1LYL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urotensin-2 family.|||Secreted http://togogenome.org/gene/9646:ARL2BP ^@ http://purl.uniprot.org/uniprot/G1MEW0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARL2BP family.|||Cytoplasm|||Mitochondrion intermembrane space|||Nucleus|||Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.|||centrosome|||cilium basal body http://togogenome.org/gene/9646:RPS21 ^@ http://purl.uniprot.org/uniprot/F2X220 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS21 family.|||Component of the 40S small ribosomal subunit.|||Endoplasmic reticulum|||Rough endoplasmic reticulum|||cytosol http://togogenome.org/gene/9646:NFYB ^@ http://purl.uniprot.org/uniprot/A0A7N5P6U4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NFYB/HAP3 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.|||Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP. http://togogenome.org/gene/9646:TBC1D23 ^@ http://purl.uniprot.org/uniprot/G1LBJ3|||http://purl.uniprot.org/uniprot/G1LBJ7 ^@ Subcellular Location Annotation ^@ trans-Golgi network http://togogenome.org/gene/9646:CALHM3 ^@ http://purl.uniprot.org/uniprot/D2GXY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9646:MRPL54 ^@ http://purl.uniprot.org/uniprot/A0A7N5KDD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL54 family.|||Mitochondrion http://togogenome.org/gene/9646:MMP7 ^@ http://purl.uniprot.org/uniprot/G1LU30 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9646:MUL1 ^@ http://purl.uniprot.org/uniprot/D2H287 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:LOC100467636 ^@ http://purl.uniprot.org/uniprot/D2I7P3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:APCS ^@ http://purl.uniprot.org/uniprot/A0A7N5KKF6 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pentraxin family.|||Binds 2 calcium ions per subunit.|||Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.|||Secreted http://togogenome.org/gene/9646:LOC100482898 ^@ http://purl.uniprot.org/uniprot/D2I6Q2 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:SLC25A35 ^@ http://purl.uniprot.org/uniprot/A0A7N5JWB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9646:ATP23 ^@ http://purl.uniprot.org/uniprot/D2H327 ^@ Similarity ^@ Belongs to the peptidase M76 family. http://togogenome.org/gene/9646:ITM2A ^@ http://purl.uniprot.org/uniprot/D2I1H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITM2 family.|||Membrane http://togogenome.org/gene/9646:CLDN4 ^@ http://purl.uniprot.org/uniprot/D2HMA1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9646:ATXN7L3 ^@ http://purl.uniprot.org/uniprot/G1MJ46 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SGF11 family.|||Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ENY2 and USP22.|||Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex. Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B.|||Nucleus|||The C-terminal SGF11-type zinc-finger domain together with the C-terminal catalytic domain of USP22 forms the 'catalytic lobe' of the SAGA deubiquitination module.|||The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module. http://togogenome.org/gene/9646:SLC30A7 ^@ http://purl.uniprot.org/uniprot/G1LSW6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Functions as a zinc transporter.|||Homooligomer.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9646:SYNDIG1L ^@ http://purl.uniprot.org/uniprot/D2GZW7 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9646:SLC16A6 ^@ http://purl.uniprot.org/uniprot/D2HSY3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:WARS2 ^@ http://purl.uniprot.org/uniprot/G1LNE9 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9646:C11H1orf158 ^@ http://purl.uniprot.org/uniprot/A0A7N5KD43 ^@ Function|||Subcellular Location Annotation ^@ Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.|||cilium axoneme http://togogenome.org/gene/9646:CCNH ^@ http://purl.uniprot.org/uniprot/G1M3Z9 ^@ Function|||Similarity|||Subunit ^@ Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.|||Belongs to the cyclin family. Cyclin C subfamily.|||Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. http://togogenome.org/gene/9646:SCNM1 ^@ http://purl.uniprot.org/uniprot/G1L251 ^@ Subcellular Location Annotation ^@ Nucleus speckle|||nucleoplasm http://togogenome.org/gene/9646:SLC39A10 ^@ http://purl.uniprot.org/uniprot/D2H628 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:CD2 ^@ http://purl.uniprot.org/uniprot/D2HMI8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:SMC5 ^@ http://purl.uniprot.org/uniprot/G1LKK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC5 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/9646:DSEL ^@ http://purl.uniprot.org/uniprot/G1MLL3 ^@ Similarity ^@ Belongs to the dermatan-sulfate isomerase family. http://togogenome.org/gene/9646:LPCAT2 ^@ http://purl.uniprot.org/uniprot/D2GTV1 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9646:MTHFD1 ^@ http://purl.uniprot.org/uniprot/G1LB74 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.|||In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. http://togogenome.org/gene/9646:C8H11orf54 ^@ http://purl.uniprot.org/uniprot/G1M2K4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.|||Monomer.|||Nucleus http://togogenome.org/gene/9646:IMP3 ^@ http://purl.uniprot.org/uniprot/D2HRJ9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/9646:SERPIND1 ^@ http://purl.uniprot.org/uniprot/D2HUL0 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9646:PADI2 ^@ http://purl.uniprot.org/uniprot/D2HNM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein arginine deiminase family.|||Cytoplasm http://togogenome.org/gene/9646:POPDC2 ^@ http://purl.uniprot.org/uniprot/A0A7N5P633|||http://purl.uniprot.org/uniprot/G1LKR1|||http://purl.uniprot.org/uniprot/G1LKR7 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/9646:MAF1 ^@ http://purl.uniprot.org/uniprot/D2HIN6 ^@ Similarity ^@ Belongs to the MAF1 family. http://togogenome.org/gene/9646:LOC100479471 ^@ http://purl.uniprot.org/uniprot/D2H193 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX17 family.|||Mitochondrion intermembrane space http://togogenome.org/gene/9646:PRKG2 ^@ http://purl.uniprot.org/uniprot/A0A7N5KKI2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily. http://togogenome.org/gene/9646:LOC100469018 ^@ http://purl.uniprot.org/uniprot/A0A7N5P2R2 ^@ Caution|||Similarity ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:RAB3B ^@ http://purl.uniprot.org/uniprot/D2H2D2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/9646:ARMT1 ^@ http://purl.uniprot.org/uniprot/A0A7N5P3G6 ^@ Domain|||Function|||Similarity ^@ Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.|||Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.|||Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine. http://togogenome.org/gene/9646:LHX8 ^@ http://purl.uniprot.org/uniprot/G1L9U3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:SLC39A6 ^@ http://purl.uniprot.org/uniprot/D2HQD5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:LOC100476320 ^@ http://purl.uniprot.org/uniprot/D2HKT3 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:GPX8 ^@ http://purl.uniprot.org/uniprot/D2I0X9 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/9646:ZHX1 ^@ http://purl.uniprot.org/uniprot/D2HPH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZHX family.|||Nucleus http://togogenome.org/gene/9646:WDR44 ^@ http://purl.uniprot.org/uniprot/D2H3B6 ^@ Subcellular Location Annotation ^@ trans-Golgi network http://togogenome.org/gene/9646:LOC100481385 ^@ http://purl.uniprot.org/uniprot/D2I2N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eutherian X-chromosome-specific Armcx family.|||Membrane http://togogenome.org/gene/9646:CANT1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KMJ3|||http://purl.uniprot.org/uniprot/D2H9A9 ^@ Similarity ^@ Belongs to the apyrase family. http://togogenome.org/gene/9646:ATP5MC3 ^@ http://purl.uniprot.org/uniprot/G1M112 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/9646:SLC39A5 ^@ http://purl.uniprot.org/uniprot/D2H349 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:MRPL33 ^@ http://purl.uniprot.org/uniprot/G1L2V1 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/9646:MEIS1 ^@ http://purl.uniprot.org/uniprot/A0A7N5K5M7|||http://purl.uniprot.org/uniprot/G1MBB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/9646:PGM1 ^@ http://purl.uniprot.org/uniprot/G1M967 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/9646:FBXO25 ^@ http://purl.uniprot.org/uniprot/D2I1A0|||http://purl.uniprot.org/uniprot/G1M8P9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:RMI1 ^@ http://purl.uniprot.org/uniprot/G1MM83 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RMI1 family.|||Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.|||Nucleus http://togogenome.org/gene/9646:LOC100480698 ^@ http://purl.uniprot.org/uniprot/D2HRC7 ^@ Similarity ^@ Belongs to the GST superfamily. Theta family. http://togogenome.org/gene/9646:TALDO1 ^@ http://purl.uniprot.org/uniprot/D2I730 ^@ Function|||Similarity ^@ Belongs to the transaldolase family. Type 1 subfamily.|||Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate. http://togogenome.org/gene/9646:CHML ^@ http://purl.uniprot.org/uniprot/D2H9H4 ^@ Similarity ^@ Belongs to the Rab GDI family. http://togogenome.org/gene/9646:SLC25A15 ^@ http://purl.uniprot.org/uniprot/G1LZ26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9646:IPO9 ^@ http://purl.uniprot.org/uniprot/G1M063 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:DPH2 ^@ http://purl.uniprot.org/uniprot/G1L2Q9 ^@ Function|||Similarity ^@ Belongs to the DPH1/DPH2 family. DPH2 subfamily.|||Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit. http://togogenome.org/gene/9646:TMEFF2 ^@ http://purl.uniprot.org/uniprot/G1M6W2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:MAT2B ^@ http://purl.uniprot.org/uniprot/A0A7N5JLL9|||http://purl.uniprot.org/uniprot/G1LF26 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.|||Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.|||Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. http://togogenome.org/gene/9646:GDF9 ^@ http://purl.uniprot.org/uniprot/C5HV43 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.|||Secreted http://togogenome.org/gene/9646:FAM219A ^@ http://purl.uniprot.org/uniprot/A0A7N5KLD5 ^@ Similarity ^@ Belongs to the FAM219 family. http://togogenome.org/gene/9646:BRPF1 ^@ http://purl.uniprot.org/uniprot/A0A7N5K8J2|||http://purl.uniprot.org/uniprot/D2HRB1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:LOC100472384 ^@ http://purl.uniprot.org/uniprot/D2HU89 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/9646:TAF1A ^@ http://purl.uniprot.org/uniprot/G1LK10 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits.|||Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.|||Nucleus http://togogenome.org/gene/9646:TMEM192 ^@ http://purl.uniprot.org/uniprot/G1LG02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM192 family.|||Late endosome|||Lysosome membrane|||Membrane http://togogenome.org/gene/9646:CAPN7 ^@ http://purl.uniprot.org/uniprot/D2H1G2 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9646:DCTN1 ^@ http://purl.uniprot.org/uniprot/A0A7N5P277 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin 150 kDa subunit family.|||cell cortex|||cytoskeleton http://togogenome.org/gene/9646:SPSB1 ^@ http://purl.uniprot.org/uniprot/D2HA29 ^@ Similarity ^@ Belongs to the SPSB family. http://togogenome.org/gene/9646:CHGA ^@ http://purl.uniprot.org/uniprot/G1M4X7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromogranin/secretogranin protein family.|||Secreted http://togogenome.org/gene/9646:EFHC2 ^@ http://purl.uniprot.org/uniprot/G1MGP4 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9646:C8H1orf43 ^@ http://purl.uniprot.org/uniprot/D2HJP2 ^@ Function|||Subcellular Location Annotation ^@ General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.|||Golgi apparatus|||Membrane|||Mitochondrion http://togogenome.org/gene/9646:GNB4 ^@ http://purl.uniprot.org/uniprot/G1LWF1 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/9646:RPLP1 ^@ http://purl.uniprot.org/uniprot/A9XSS6 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/9646:CERS3 ^@ http://purl.uniprot.org/uniprot/G1M7E0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9646:BET1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JSZ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:KAT7 ^@ http://purl.uniprot.org/uniprot/G1M0R5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/9646:LOC100467668 ^@ http://purl.uniprot.org/uniprot/A0A7N5JCX3|||http://purl.uniprot.org/uniprot/A0A7N5KHI5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat HIR1 family.|||Nucleus|||Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle. http://togogenome.org/gene/9646:SLC9A4 ^@ http://purl.uniprot.org/uniprot/D2GWX7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Interacts with CHP1 and CHP2.|||Membrane http://togogenome.org/gene/9646:KIF20A ^@ http://purl.uniprot.org/uniprot/D2HK91 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9646:YOD1 ^@ http://purl.uniprot.org/uniprot/D2I0M3 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin. http://togogenome.org/gene/9646:RABGGTA ^@ http://purl.uniprot.org/uniprot/G1MCH3 ^@ Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family.|||Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.|||Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. http://togogenome.org/gene/9646:PPP1R10 ^@ http://purl.uniprot.org/uniprot/D2I133|||http://purl.uniprot.org/uniprot/G1M3W3 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers. http://togogenome.org/gene/9646:GPC3 ^@ http://purl.uniprot.org/uniprot/A0A7N5P7E2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/9646:LOC100464344 ^@ http://purl.uniprot.org/uniprot/D2HL27 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:NEU1 ^@ http://purl.uniprot.org/uniprot/D2I745 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/9646:AZIN2 ^@ http://purl.uniprot.org/uniprot/G1LLE6 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/9646:DOK3 ^@ http://purl.uniprot.org/uniprot/G1MIA8 ^@ Similarity ^@ Belongs to the DOK family. Type A subfamily. http://togogenome.org/gene/9646:NUMB ^@ http://purl.uniprot.org/uniprot/A0A7N5KL10 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Plays a role in the process of neurogenesis. http://togogenome.org/gene/9646:LOC100479982 ^@ http://purl.uniprot.org/uniprot/G1M2B6 ^@ Similarity ^@ Belongs to the SSX family. http://togogenome.org/gene/9646:PSMD1 ^@ http://purl.uniprot.org/uniprot/G1MDC4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S1 family.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. http://togogenome.org/gene/9646:CAMK2N2 ^@ http://purl.uniprot.org/uniprot/G1MFM6 ^@ Similarity ^@ Belongs to the CAMK2N family. http://togogenome.org/gene/9646:GPR119 ^@ http://purl.uniprot.org/uniprot/D2H9U6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:KEG54_p04 ^@ http://purl.uniprot.org/uniprot/A5JFK5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 4 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9646:KEG54_p01 ^@ http://purl.uniprot.org/uniprot/Q33784 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome b family.|||Binds 2 heme b groups non-covalently.|||Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.|||Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.|||Mitochondrion inner membrane|||The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.|||The full-length protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools. http://togogenome.org/gene/9646:LOC100478013 ^@ http://purl.uniprot.org/uniprot/G1L290 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9646:KRT23 ^@ http://purl.uniprot.org/uniprot/G1LP05 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9646:PDE4A ^@ http://purl.uniprot.org/uniprot/A0A7N5JBH8|||http://purl.uniprot.org/uniprot/A0A7N5JLU8|||http://purl.uniprot.org/uniprot/G1LYH1 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9646:FAM234B ^@ http://purl.uniprot.org/uniprot/G1LW18 ^@ Similarity ^@ Belongs to the FAM234 family. http://togogenome.org/gene/9646:RPE65 ^@ http://purl.uniprot.org/uniprot/G1L0Y3 ^@ Cofactor|||Similarity ^@ Belongs to the carotenoid oxygenase family.|||Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/9646:MC2R ^@ http://purl.uniprot.org/uniprot/G1MLV3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).|||Membrane http://togogenome.org/gene/9646:TPT1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KLB3 ^@ Similarity ^@ Belongs to the TCTP family. http://togogenome.org/gene/9646:NXT1 ^@ http://purl.uniprot.org/uniprot/D2HSG8 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/9646:STARD6 ^@ http://purl.uniprot.org/uniprot/G1MFM4 ^@ Function ^@ May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols. http://togogenome.org/gene/9646:IL10 ^@ http://purl.uniprot.org/uniprot/G1MGJ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-10 family.|||Homodimer. Interacts with IL10RA and IL10RB.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/9646:RECQL ^@ http://purl.uniprot.org/uniprot/A0A7N5JIQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RecQ subfamily.|||Nucleus http://togogenome.org/gene/9646:C3AR1 ^@ http://purl.uniprot.org/uniprot/G1ML29 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Interacts with VGF-derived peptide TLQP-21.|||Membrane|||Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. http://togogenome.org/gene/9646:SUPV3L1 ^@ http://purl.uniprot.org/uniprot/D2GXI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family.|||mitochondrion nucleoid http://togogenome.org/gene/9646:OAZ2 ^@ http://purl.uniprot.org/uniprot/A0A7N5P2S4 ^@ Similarity ^@ Belongs to the ODC antizyme family. http://togogenome.org/gene/9646:PIK3CG ^@ http://purl.uniprot.org/uniprot/D2GX94 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9646:FMO1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JKA6|||http://purl.uniprot.org/uniprot/D2I021 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:NAA60 ^@ http://purl.uniprot.org/uniprot/A0A7N5J9Q4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. NAA60 subfamily.|||Golgi apparatus membrane http://togogenome.org/gene/9646:LOC100479209 ^@ http://purl.uniprot.org/uniprot/G1M3H7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:MRPS25 ^@ http://purl.uniprot.org/uniprot/D2HGM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS25 family.|||Mitochondrion http://togogenome.org/gene/9646:KEG54_p03 ^@ http://purl.uniprot.org/uniprot/A5JFK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 5 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9646:MDH1 ^@ http://purl.uniprot.org/uniprot/G1LFQ4 ^@ Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 2 family.|||Homodimer. http://togogenome.org/gene/9646:TXLNA ^@ http://purl.uniprot.org/uniprot/D2HI61 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/9646:ERBB2 ^@ http://purl.uniprot.org/uniprot/A0A7N5K3C5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/9646:GART ^@ http://purl.uniprot.org/uniprot/D2HCF9 ^@ Similarity ^@ In the C-terminal section; belongs to the GART family.|||In the N-terminal section; belongs to the GARS family.|||In the central section; belongs to the AIR synthase family. http://togogenome.org/gene/9646:PIGO ^@ http://purl.uniprot.org/uniprot/D2I1Z6|||http://purl.uniprot.org/uniprot/G1MAI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:ASB17 ^@ http://purl.uniprot.org/uniprot/G1LAB7 ^@ Function ^@ May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/9646:CLTC ^@ http://purl.uniprot.org/uniprot/A0A7N5P1W3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin heavy chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||Membrane|||coated pit http://togogenome.org/gene/9646:TBL1XR1 ^@ http://purl.uniprot.org/uniprot/A0A7N5K9A2 ^@ Similarity ^@ Belongs to the WD repeat EBI family. http://togogenome.org/gene/9646:TPR ^@ http://purl.uniprot.org/uniprot/G1MAI0 ^@ Similarity ^@ Belongs to the TPR family. http://togogenome.org/gene/9646:C9 ^@ http://purl.uniprot.org/uniprot/A0A7N5K551|||http://purl.uniprot.org/uniprot/G1MFD4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9646:CPPED1 ^@ http://purl.uniprot.org/uniprot/G1LXY1 ^@ Function|||Similarity ^@ Belongs to the metallophosphoesterase superfamily. CPPED1 family.|||Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes. http://togogenome.org/gene/9646:MAGT1 ^@ http://purl.uniprot.org/uniprot/G1LHS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:HSD17B4 ^@ http://purl.uniprot.org/uniprot/A0A7N5P1M9 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/9646:GTF2H5 ^@ http://purl.uniprot.org/uniprot/A0A7N5K323 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB5 family.|||Component of the 7-subunit TFIIH core complex.|||In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.|||Nucleus http://togogenome.org/gene/9646:LOC100479359 ^@ http://purl.uniprot.org/uniprot/D2HP45 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:SEC24A ^@ http://purl.uniprot.org/uniprot/D2GVJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9646:LOC100476859 ^@ http://purl.uniprot.org/uniprot/D2I5D0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:TNP2 ^@ http://purl.uniprot.org/uniprot/A0A7N5KGS7 ^@ Similarity ^@ Belongs to the nuclear transition protein 2 family. http://togogenome.org/gene/9646:ASPA ^@ http://purl.uniprot.org/uniprot/D2HZN6 ^@ Cofactor|||Similarity ^@ Belongs to the AspA/AstE family. Aspartoacylase subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9646:LOC100468148 ^@ http://purl.uniprot.org/uniprot/D2H0T7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c-type heme lyase family.|||Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9646:RC3H1 ^@ http://purl.uniprot.org/uniprot/D2H5I4 ^@ Subcellular Location Annotation ^@ P-body http://togogenome.org/gene/9646:UFD1 ^@ http://purl.uniprot.org/uniprot/G1LY74 ^@ Similarity ^@ Belongs to the UFD1 family. http://togogenome.org/gene/9646:VARS2 ^@ http://purl.uniprot.org/uniprot/G1M340 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9646:OTC ^@ http://purl.uniprot.org/uniprot/G1LKR6 ^@ Similarity|||Subunit ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily.|||Homotrimer. http://togogenome.org/gene/9646:CAMK2N1 ^@ http://purl.uniprot.org/uniprot/G1L953 ^@ Similarity ^@ Belongs to the CAMK2N family. http://togogenome.org/gene/9646:TMA16 ^@ http://purl.uniprot.org/uniprot/G1L2U3 ^@ Function|||Similarity|||Subunit ^@ Associates with pre-60S ribosomal particles.|||Belongs to the TMA16 family.|||Involved in the biogenesis of the 60S ribosomal subunit in the nucleus. http://togogenome.org/gene/9646:MSL3 ^@ http://purl.uniprot.org/uniprot/A0A7N5P853 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:RPL27 ^@ http://purl.uniprot.org/uniprot/G1L014 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL27 family.|||Endoplasmic reticulum|||Rough endoplasmic reticulum http://togogenome.org/gene/9646:RPS6KB1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KAV6|||http://purl.uniprot.org/uniprot/D2HLU3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9646:RPL17 ^@ http://purl.uniprot.org/uniprot/F2X254 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/9646:HCAR2 ^@ http://purl.uniprot.org/uniprot/G1MMR8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:NAF1 ^@ http://purl.uniprot.org/uniprot/D2HXK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAF1 family.|||Nucleus http://togogenome.org/gene/9646:KCNA1 ^@ http://purl.uniprot.org/uniprot/D2HEJ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:B3GALNT1 ^@ http://purl.uniprot.org/uniprot/D2HVY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:CCDC172 ^@ http://purl.uniprot.org/uniprot/G1M5P6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC172 family.|||Cytoplasm http://togogenome.org/gene/9646:LOC100471180 ^@ http://purl.uniprot.org/uniprot/G1M606 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9646:TBX20 ^@ http://purl.uniprot.org/uniprot/D2HA06 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9646:SERPINF1 ^@ http://purl.uniprot.org/uniprot/G1LML8 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9646:COPS7B ^@ http://purl.uniprot.org/uniprot/A0A7N5KQL7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:VCP ^@ http://purl.uniprot.org/uniprot/G1MAF6 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9646:PTPN3 ^@ http://purl.uniprot.org/uniprot/A0A7N5K725 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||May act at junctions between the membrane and the cytoskeleton.|||cytoskeleton http://togogenome.org/gene/9646:SNX3 ^@ http://purl.uniprot.org/uniprot/D2H6J3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome|||Endosome|||phagosome http://togogenome.org/gene/9646:TIGD4 ^@ http://purl.uniprot.org/uniprot/G1MLG7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:UBE2L3 ^@ http://purl.uniprot.org/uniprot/A0A7N5KEP5 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9646:CASD1 ^@ http://purl.uniprot.org/uniprot/D2H8U7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PC-esterase family. CASD1 subfamily.|||Membrane http://togogenome.org/gene/9646:ST8SIA5 ^@ http://purl.uniprot.org/uniprot/A0A7N5KKL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9646:UTP25 ^@ http://purl.uniprot.org/uniprot/D2HIJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP25 family.|||nucleolus http://togogenome.org/gene/9646:RPSA ^@ http://purl.uniprot.org/uniprot/D2HZN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS2 family.|||Cytoplasm http://togogenome.org/gene/9646:MRPL13 ^@ http://purl.uniprot.org/uniprot/G1L619 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/9646:USP15 ^@ http://purl.uniprot.org/uniprot/A0A7N5KL11|||http://purl.uniprot.org/uniprot/D2HCH7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Cytoplasm|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Nucleus http://togogenome.org/gene/9646:MRPL46 ^@ http://purl.uniprot.org/uniprot/D2HCD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL46 family.|||Mitochondrion http://togogenome.org/gene/9646:ADAMTS15 ^@ http://purl.uniprot.org/uniprot/D2GUW8 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9646:GDF2 ^@ http://purl.uniprot.org/uniprot/D2I4F5 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9646:EIF5A2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JS63 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Endoplasmic reticulum membrane|||Membrane|||Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.|||eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group. http://togogenome.org/gene/9646:NFXL1 ^@ http://purl.uniprot.org/uniprot/G1L963 ^@ Similarity ^@ Belongs to the NFX1 family. http://togogenome.org/gene/9646:RFX3 ^@ http://purl.uniprot.org/uniprot/G1M0E9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:PAIP2B ^@ http://purl.uniprot.org/uniprot/G1MBG4 ^@ Similarity ^@ Belongs to the PAIP2 family. http://togogenome.org/gene/9646:CDK4 ^@ http://purl.uniprot.org/uniprot/D2H394 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9646:C5 ^@ http://purl.uniprot.org/uniprot/G1L2Q2 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9646:CNEP1R1 ^@ http://purl.uniprot.org/uniprot/G1LIS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNEP1R1 family.|||Cytoplasm|||Membrane|||Nucleus membrane http://togogenome.org/gene/9646:SNAP23 ^@ http://purl.uniprot.org/uniprot/G1MBC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP-25 family.|||Cell membrane|||Membrane|||synaptosome http://togogenome.org/gene/9646:SERPINC1 ^@ http://purl.uniprot.org/uniprot/G1MAY6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the serpin family.|||Forms protease inhibiting heterodimer with TMPRSS7.|||extracellular space http://togogenome.org/gene/9646:MAGI3 ^@ http://purl.uniprot.org/uniprot/G1L9K5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:SRD5A3 ^@ http://purl.uniprot.org/uniprot/D2HBV9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.|||Endoplasmic reticulum membrane|||Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT). http://togogenome.org/gene/9646:EMG1 ^@ http://purl.uniprot.org/uniprot/D2HIZ9 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family. http://togogenome.org/gene/9646:LOC100481888 ^@ http://purl.uniprot.org/uniprot/G1L036 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily. http://togogenome.org/gene/9646:TGM5 ^@ http://purl.uniprot.org/uniprot/G1MAR9 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9646:LOC100481887 ^@ http://purl.uniprot.org/uniprot/G1M666 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Membrane http://togogenome.org/gene/9646:LOC100463546 ^@ http://purl.uniprot.org/uniprot/D2H2E3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the hcp beta-lactamase family.|||Mitochondrion intermembrane space|||Required for assembly of mitochondrial respiratory chain complexes. http://togogenome.org/gene/9646:IKBKB ^@ http://purl.uniprot.org/uniprot/A0A7N5JDS8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9646:MRPL51 ^@ http://purl.uniprot.org/uniprot/D2HJ21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL51 family.|||Mitochondrion http://togogenome.org/gene/9646:HBEGF ^@ http://purl.uniprot.org/uniprot/A0A7N5KEF7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:NPSR1 ^@ http://purl.uniprot.org/uniprot/G1L4I8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:MTF2 ^@ http://purl.uniprot.org/uniprot/G1LTG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Polycomblike family.|||Nucleus http://togogenome.org/gene/9646:LOC100468905 ^@ http://purl.uniprot.org/uniprot/G1L767 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/9646:CPXM1 ^@ http://purl.uniprot.org/uniprot/G1LXJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||Secreted http://togogenome.org/gene/9646:PTCD3 ^@ http://purl.uniprot.org/uniprot/G1LH43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS39 family.|||Mitochondrion http://togogenome.org/gene/9646:RPS25 ^@ http://purl.uniprot.org/uniprot/C6ZIA4 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS25 family.|||Component of the small ribosomal subunit. http://togogenome.org/gene/9646:ING1 ^@ http://purl.uniprot.org/uniprot/G1MF89 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9646:ADGRL4 ^@ http://purl.uniprot.org/uniprot/G1MIU4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:UNC5C ^@ http://purl.uniprot.org/uniprot/A0A7N5JIU3|||http://purl.uniprot.org/uniprot/G1LHL6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-5 family.|||Cell membrane|||Membrane|||Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. http://togogenome.org/gene/9646:SIGMAR1 ^@ http://purl.uniprot.org/uniprot/D2I5R7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ERG2 family.|||Cell junction|||Cytoplasmic vesicle|||Endoplasmic reticulum membrane|||Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.|||Homotrimer.|||Lipid droplet|||Membrane|||Nucleus envelope|||Nucleus inner membrane|||Nucleus outer membrane|||Postsynaptic density membrane|||The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.|||Vesicle|||growth cone http://togogenome.org/gene/9646:LOC100473307 ^@ http://purl.uniprot.org/uniprot/G1L479 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:CRYBA2 ^@ http://purl.uniprot.org/uniprot/D2GXC2 ^@ Function|||Similarity ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens. http://togogenome.org/gene/9646:LIPG ^@ http://purl.uniprot.org/uniprot/A0A7N5K5N8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9646:DLG5 ^@ http://purl.uniprot.org/uniprot/D2H986 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:PI4KB ^@ http://purl.uniprot.org/uniprot/A0A7N5JM62|||http://purl.uniprot.org/uniprot/A0A7N5KC82 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9646:CPNE3 ^@ http://purl.uniprot.org/uniprot/D2H5C8 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9646:VWA2 ^@ http://purl.uniprot.org/uniprot/A0A7N5K398|||http://purl.uniprot.org/uniprot/A0A7N5KPH3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:LOC100466888 ^@ http://purl.uniprot.org/uniprot/A0A7N5JDC4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.|||Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. http://togogenome.org/gene/9646:CIRBP ^@ http://purl.uniprot.org/uniprot/A0A7N5KLY9|||http://purl.uniprot.org/uniprot/G1L986 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with EIF4G1. Associates with ribosomes.|||nucleoplasm http://togogenome.org/gene/9646:LOC100467551 ^@ http://purl.uniprot.org/uniprot/G1LQL0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9646:MFAP2 ^@ http://purl.uniprot.org/uniprot/G1L0V0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MFAP family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9646:DGLUCY ^@ http://purl.uniprot.org/uniprot/G1L4I2 ^@ Similarity ^@ Belongs to the D-glutamate cyclase family. http://togogenome.org/gene/9646:SEC31A ^@ http://purl.uniprot.org/uniprot/A0A7N5KFD7|||http://purl.uniprot.org/uniprot/A0A7N5KS88|||http://purl.uniprot.org/uniprot/D2GUF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC31 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9646:ALB ^@ http://purl.uniprot.org/uniprot/G1LEJ5 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9646:CAV3 ^@ http://purl.uniprot.org/uniprot/A0A7N5P346 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||caveola http://togogenome.org/gene/9646:LOC100484526 ^@ http://purl.uniprot.org/uniprot/G1M8S8 ^@ Similarity ^@ Belongs to the copper type II ascorbate-dependent monooxygenase family. http://togogenome.org/gene/9646:PROKR1 ^@ http://purl.uniprot.org/uniprot/D2I171 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:TPM2 ^@ http://purl.uniprot.org/uniprot/G1LSK6|||http://purl.uniprot.org/uniprot/G1LTE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9646:AIG1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KFN7|||http://purl.uniprot.org/uniprot/A0A7N5KNI4|||http://purl.uniprot.org/uniprot/A0A7N5KR13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIG1 family.|||Membrane http://togogenome.org/gene/9646:CA5A ^@ http://purl.uniprot.org/uniprot/A0A7N5P7R4 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9646:BLVRA ^@ http://purl.uniprot.org/uniprot/A0A7N5JA78 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily.|||Monomer.|||Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.|||cytosol http://togogenome.org/gene/9646:MDH1B ^@ http://purl.uniprot.org/uniprot/G1L873 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. MDH type 2 family. http://togogenome.org/gene/9646:LOC100475287 ^@ http://purl.uniprot.org/uniprot/G1MKL0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:HPS6 ^@ http://purl.uniprot.org/uniprot/G1MPH5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6. Interacts with HPS5 and HPS3. Interacts with biogenesis of lysosome-related organelles complex-1 (BLOC1). Interacts with AP-3 complex.|||May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.|||Microsome membrane http://togogenome.org/gene/9646:FGF12 ^@ http://purl.uniprot.org/uniprot/G1LQH1 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9646:CSRNP2 ^@ http://purl.uniprot.org/uniprot/D2HHE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AXUD1 family.|||Nucleus http://togogenome.org/gene/9646:SRP54 ^@ http://purl.uniprot.org/uniprot/G1MAQ1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. Interacts with RNPS1. Interacts with the SRP receptor subunit SRPRA.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development.|||Cytoplasm|||Endoplasmic reticulum|||Nucleus speckle|||The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.|||The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER. http://togogenome.org/gene/9646:SMG9 ^@ http://purl.uniprot.org/uniprot/G1LC28 ^@ Similarity ^@ Belongs to the SMG9 family. http://togogenome.org/gene/9646:LOC100477257 ^@ http://purl.uniprot.org/uniprot/D2I0K6 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/9646:MFNG ^@ http://purl.uniprot.org/uniprot/G1LTS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:LOC100481285 ^@ http://purl.uniprot.org/uniprot/D2HZU2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9646:CLCN3 ^@ http://purl.uniprot.org/uniprot/A0A7N5K803|||http://purl.uniprot.org/uniprot/D2H8P8|||http://purl.uniprot.org/uniprot/G1M3S1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.|||Cell membrane|||Early endosome membrane|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9646:CACNA2D1 ^@ http://purl.uniprot.org/uniprot/A0A7N5K985|||http://purl.uniprot.org/uniprot/G1ME42 ^@ Similarity ^@ Belongs to the calcium channel subunit alpha-2/delta family. http://togogenome.org/gene/9646:RAD9A ^@ http://purl.uniprot.org/uniprot/D2HGP8 ^@ Similarity ^@ Belongs to the rad9 family. http://togogenome.org/gene/9646:STAG2 ^@ http://purl.uniprot.org/uniprot/G1MBD1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||centromere http://togogenome.org/gene/9646:RPE ^@ http://purl.uniprot.org/uniprot/D2HJA5 ^@ Cofactor|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/9646:TIMM8B ^@ http://purl.uniprot.org/uniprot/D2HG80 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9646:HOXA2 ^@ http://purl.uniprot.org/uniprot/D2GVC1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:CETN2 ^@ http://purl.uniprot.org/uniprot/G1L0I0 ^@ Similarity ^@ Belongs to the centrin family. http://togogenome.org/gene/9646:CCL5 ^@ http://purl.uniprot.org/uniprot/A0A7N5JVR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9646:ING4 ^@ http://purl.uniprot.org/uniprot/G1M6E8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9646:C1S ^@ http://purl.uniprot.org/uniprot/G1M541 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:SLC25A37 ^@ http://purl.uniprot.org/uniprot/D2H029 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9646:POU3F4 ^@ http://purl.uniprot.org/uniprot/D2I4C0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-3 subfamily.|||Nucleus http://togogenome.org/gene/9646:IPMK ^@ http://purl.uniprot.org/uniprot/D2I215|||http://purl.uniprot.org/uniprot/G1LUP1 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9646:GNRH1 ^@ http://purl.uniprot.org/uniprot/G1L0K0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GnRH family.|||Secreted|||Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones. http://togogenome.org/gene/9646:WNT2B ^@ http://purl.uniprot.org/uniprot/G1LA82 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9646:FXR1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KIC5|||http://purl.uniprot.org/uniprot/A0A7N5KL63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMR1 family.|||Cytoplasmic ribonucleoprotein granule|||Nucleus envelope|||Postsynapse|||Synapse|||dendritic spine http://togogenome.org/gene/9646:PCNX4 ^@ http://purl.uniprot.org/uniprot/G1L837 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pecanex family.|||Membrane http://togogenome.org/gene/9646:ZFX ^@ http://purl.uniprot.org/uniprot/G1M1Z9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:GIPR ^@ http://purl.uniprot.org/uniprot/D2I071 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:DNAAF4 ^@ http://purl.uniprot.org/uniprot/D2HKV7 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Dynein axonemal particle|||neuron projection http://togogenome.org/gene/9646:PPARGC1B ^@ http://purl.uniprot.org/uniprot/D2H8M8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:POLR3H ^@ http://purl.uniprot.org/uniprot/A0A7N5P9Z4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/9646:LOC100483137 ^@ http://purl.uniprot.org/uniprot/D2HZN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:IL5 ^@ http://purl.uniprot.org/uniprot/G1MH72 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-5 family.|||Homodimer; disulfide-linked. Interacts with IL5RA. Interacts with CSF2RB.|||Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (By similarity). Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively.|||Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively.|||Secreted http://togogenome.org/gene/9646:PSMD7 ^@ http://purl.uniprot.org/uniprot/A0A7N5JNG0 ^@ Similarity ^@ Belongs to the peptidase M67A family. http://togogenome.org/gene/9646:UTP23 ^@ http://purl.uniprot.org/uniprot/G1LUU0 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9646:LRRC8B ^@ http://purl.uniprot.org/uniprot/D2HJK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:PARK7 ^@ http://purl.uniprot.org/uniprot/D2HA21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C56 family.|||Membrane raft http://togogenome.org/gene/9646:SLC43A1 ^@ http://purl.uniprot.org/uniprot/G1M7G7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:MPDZ ^@ http://purl.uniprot.org/uniprot/A0A7N5K9B7|||http://purl.uniprot.org/uniprot/G1L4U6 ^@ Subcellular Location Annotation ^@ Cell membrane|||tight junction http://togogenome.org/gene/9646:MRPL41 ^@ http://purl.uniprot.org/uniprot/D2HU66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL41 family.|||Mitochondrion http://togogenome.org/gene/9646:AADACL3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JQB1 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/9646:PARD6B ^@ http://purl.uniprot.org/uniprot/A0A7N5JNY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAR6 family.|||Cytoplasm|||tight junction http://togogenome.org/gene/9646:GLB1L ^@ http://purl.uniprot.org/uniprot/D2GXB2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 35 family. http://togogenome.org/gene/9646:OLR1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KET8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:CLDN10 ^@ http://purl.uniprot.org/uniprot/D2H9Z6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9646:TSPAN31 ^@ http://purl.uniprot.org/uniprot/G1LFF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9646:HDAC1 ^@ http://purl.uniprot.org/uniprot/G1LM86 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins.|||Nucleus http://togogenome.org/gene/9646:PEX19 ^@ http://purl.uniprot.org/uniprot/A0A7N5JF82 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxin-19 family.|||Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.|||Membrane|||Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.|||Peroxisome membrane http://togogenome.org/gene/9646:NIF3L1 ^@ http://purl.uniprot.org/uniprot/D2H2Q0 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/9646:CCKBR ^@ http://purl.uniprot.org/uniprot/D2HR68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:SERPINB1 ^@ http://purl.uniprot.org/uniprot/D2I4F1 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9646:EIF3M ^@ http://purl.uniprot.org/uniprot/G1LKE6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Belongs to the eIF-3 subunit M family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm http://togogenome.org/gene/9646:AK5 ^@ http://purl.uniprot.org/uniprot/G1LKZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylate kinase family.|||Cytoplasm http://togogenome.org/gene/9646:UBE3A ^@ http://purl.uniprot.org/uniprot/G1LKJ5 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.|||Nucleus http://togogenome.org/gene/9646:KCNT2 ^@ http://purl.uniprot.org/uniprot/D2HWF1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9646:GOLM2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JQR1|||http://purl.uniprot.org/uniprot/G1M9E5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLM family.|||Membrane http://togogenome.org/gene/9646:AOX2 ^@ http://purl.uniprot.org/uniprot/G1LGX7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/9646:SGO1 ^@ http://purl.uniprot.org/uniprot/G1L248 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shugoshin family.|||centromere http://togogenome.org/gene/9646:GTPBP3 ^@ http://purl.uniprot.org/uniprot/G1LVE0 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. http://togogenome.org/gene/9646:KATNA1 ^@ http://purl.uniprot.org/uniprot/D2HEQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||spindle http://togogenome.org/gene/9646:LOC100464393 ^@ http://purl.uniprot.org/uniprot/G1L563 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/9646:CNMD ^@ http://purl.uniprot.org/uniprot/G1LPS0 ^@ Similarity ^@ Belongs to the chondromodulin-1 family. http://togogenome.org/gene/9646:GATA1 ^@ http://purl.uniprot.org/uniprot/D2H7N5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:HIGD2A ^@ http://purl.uniprot.org/uniprot/G1LKA4 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/9646:HBS1L ^@ http://purl.uniprot.org/uniprot/A0A7N5KM59|||http://purl.uniprot.org/uniprot/G1LTA8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:COG3 ^@ http://purl.uniprot.org/uniprot/G1M381 ^@ Function|||Similarity ^@ Belongs to the COG3 family.|||Involved in ER-Golgi transport. http://togogenome.org/gene/9646:PPCS ^@ http://purl.uniprot.org/uniprot/G1L126 ^@ Similarity ^@ Belongs to the PPC synthetase family. http://togogenome.org/gene/9646:PPP3CA ^@ http://purl.uniprot.org/uniprot/A0A7N5JYZ7|||http://purl.uniprot.org/uniprot/G1LQC9 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-2B subfamily. http://togogenome.org/gene/9646:CLIP1 ^@ http://purl.uniprot.org/uniprot/G1M838 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9646:POLR3GL ^@ http://purl.uniprot.org/uniprot/D2HQ52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC7 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/9646:MAN1A2 ^@ http://purl.uniprot.org/uniprot/D2HQ28 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9646:TRMT112 ^@ http://purl.uniprot.org/uniprot/D2H4T4 ^@ Similarity ^@ Belongs to the TRM112 family. http://togogenome.org/gene/9646:TSNAX ^@ http://purl.uniprot.org/uniprot/G1L7A3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the translin family.|||Nucleus http://togogenome.org/gene/9646:IGF1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JMM9|||http://purl.uniprot.org/uniprot/G1LIG6|||http://purl.uniprot.org/uniprot/Q6JLX1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the insulin family.|||Forms a ternary complex with IGFR1 and ITGAV:ITGB3. Forms a ternary complex with IGFR1 and ITGA6:ITGB4.|||Secreted|||The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity). http://togogenome.org/gene/9646:NDST3 ^@ http://purl.uniprot.org/uniprot/D2H9J8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/9646:YPEL4 ^@ http://purl.uniprot.org/uniprot/D2HK66 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9646:CHURC1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JKR9 ^@ Similarity ^@ Belongs to the Churchill family. http://togogenome.org/gene/9646:SDAD1 ^@ http://purl.uniprot.org/uniprot/G1LZ27 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SDA1 family.|||Required for 60S pre-ribosomal subunits export to the cytoplasm.|||nucleolus http://togogenome.org/gene/9646:LCLAT1 ^@ http://purl.uniprot.org/uniprot/A0A7N5K9A9 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9646:CRISP2 ^@ http://purl.uniprot.org/uniprot/G1LQC8 ^@ Caution|||Similarity ^@ Belongs to the CRISP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:GDF10 ^@ http://purl.uniprot.org/uniprot/D2I4F6 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9646:TMEM183A ^@ http://purl.uniprot.org/uniprot/D2HSE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM183 family.|||Membrane http://togogenome.org/gene/9646:LOC100478125 ^@ http://purl.uniprot.org/uniprot/D2I6P0 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:TACC1 ^@ http://purl.uniprot.org/uniprot/G1MAG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACC family.|||Cytoplasm http://togogenome.org/gene/9646:CACNB4 ^@ http://purl.uniprot.org/uniprot/G1LQD3|||http://purl.uniprot.org/uniprot/G1LQE1 ^@ Similarity ^@ Belongs to the calcium channel beta subunit family. http://togogenome.org/gene/9646:B4GAT1 ^@ http://purl.uniprot.org/uniprot/D2H4M1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 49 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9646:SEC23A ^@ http://purl.uniprot.org/uniprot/D2H485 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9646:TM2D3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JTI6|||http://purl.uniprot.org/uniprot/G1L8K8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:AOX4 ^@ http://purl.uniprot.org/uniprot/M1ZMK9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/9646:RRP8 ^@ http://purl.uniprot.org/uniprot/G1MCZ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methyltransferase superfamily. RRP8 family.|||Component of the eNoSC complex.|||Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase.|||nucleolus http://togogenome.org/gene/9646:TPH2 ^@ http://purl.uniprot.org/uniprot/G1L0L6 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/9646:AFF1 ^@ http://purl.uniprot.org/uniprot/G1L9J1|||http://purl.uniprot.org/uniprot/G1L9K4 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/9646:NDUFB9 ^@ http://purl.uniprot.org/uniprot/D2I1Y8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I LYR family.|||Mammalian complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:LOC100476785 ^@ http://purl.uniprot.org/uniprot/D2GXX0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9646:GATB ^@ http://purl.uniprot.org/uniprot/G1MJF3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/9646:KEG54_p12 ^@ http://purl.uniprot.org/uniprot/Q534B1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 2 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM242 (By similarity).|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:NDFIP2 ^@ http://purl.uniprot.org/uniprot/D2HDE3 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Membrane http://togogenome.org/gene/9646:IMMT ^@ http://purl.uniprot.org/uniprot/G1LHA1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic60 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:PDCL3 ^@ http://purl.uniprot.org/uniprot/G1MAY7 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9646:PSMC5 ^@ http://purl.uniprot.org/uniprot/G1L8T5 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9646:RAB29 ^@ http://purl.uniprot.org/uniprot/A0A7N5KGW3|||http://purl.uniprot.org/uniprot/D2I003 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/9646:CUL1 ^@ http://purl.uniprot.org/uniprot/D2HN20 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9646:LOC100481522 ^@ http://purl.uniprot.org/uniprot/G1M0M8 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/9646:NMNAT2 ^@ http://purl.uniprot.org/uniprot/G1L6E7 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/9646:TAF15 ^@ http://purl.uniprot.org/uniprot/G1M8L3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TET family.|||Nucleus http://togogenome.org/gene/9646:KIF9 ^@ http://purl.uniprot.org/uniprot/G1M2D9 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9646:DPH6 ^@ http://purl.uniprot.org/uniprot/G1LF73 ^@ Function|||Similarity ^@ Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.|||Belongs to the Diphthine--ammonia ligase family. http://togogenome.org/gene/9646:IL1F10 ^@ http://purl.uniprot.org/uniprot/A0A7N5JG56 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.|||Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9646:SNUPN ^@ http://purl.uniprot.org/uniprot/D2HRJ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snurportin family.|||Cytoplasm|||Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.|||Nucleus http://togogenome.org/gene/9646:RFC4 ^@ http://purl.uniprot.org/uniprot/D2H072 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/9646:LOC100474871 ^@ http://purl.uniprot.org/uniprot/G1M1M0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Functions as transport protein in the blood stream.|||Secreted http://togogenome.org/gene/9646:PAXBP1 ^@ http://purl.uniprot.org/uniprot/D2HCG8 ^@ Similarity ^@ Belongs to the GCF family. http://togogenome.org/gene/9646:SLC6A13 ^@ http://purl.uniprot.org/uniprot/A0A7N5JQB8 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily.|||Cell membrane|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9646:GNG8 ^@ http://purl.uniprot.org/uniprot/D2HL52 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9646:ZSCAN25 ^@ http://purl.uniprot.org/uniprot/D2HP64 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:KIF1B ^@ http://purl.uniprot.org/uniprot/A0A7N5JU37|||http://purl.uniprot.org/uniprot/G1LJJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.|||axon http://togogenome.org/gene/9646:INSL6 ^@ http://purl.uniprot.org/uniprot/D2HMS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/9646:GPRC5D ^@ http://purl.uniprot.org/uniprot/G1LW29 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9646:DKK3 ^@ http://purl.uniprot.org/uniprot/D2HS07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/9646:TSPAN32 ^@ http://purl.uniprot.org/uniprot/G1L602 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:PDHB ^@ http://purl.uniprot.org/uniprot/A0A7N5JY85 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. http://togogenome.org/gene/9646:ADNP ^@ http://purl.uniprot.org/uniprot/D2GVM8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:TRADD ^@ http://purl.uniprot.org/uniprot/G1MFS1 ^@ Subcellular Location Annotation ^@ Nucleus|||cytoskeleton http://togogenome.org/gene/9646:SYNGR4 ^@ http://purl.uniprot.org/uniprot/D2H801 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptogyrin family.|||Membrane http://togogenome.org/gene/9646:GJB3 ^@ http://purl.uniprot.org/uniprot/D2H619 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9646:RETREG3 ^@ http://purl.uniprot.org/uniprot/D2HIU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RETREG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:SEC22C ^@ http://purl.uniprot.org/uniprot/D2HSV5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||May be involved in vesicle transport between the ER and the Golgi complex.|||Membrane http://togogenome.org/gene/9646:FLNB ^@ http://purl.uniprot.org/uniprot/A0A7N5K6W9|||http://purl.uniprot.org/uniprot/D2GX06 ^@ Similarity ^@ Belongs to the filamin family. http://togogenome.org/gene/9646:LOC100473693 ^@ http://purl.uniprot.org/uniprot/F2X216 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS12 family. http://togogenome.org/gene/9646:SKP1 ^@ http://purl.uniprot.org/uniprot/G1MHH9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SKP1 family.|||Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit.|||Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1.|||The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. http://togogenome.org/gene/9646:RFTN2 ^@ http://purl.uniprot.org/uniprot/D2HDI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the raftlin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:KCNK18 ^@ http://purl.uniprot.org/uniprot/G1M677 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9646:CHRM5 ^@ http://purl.uniprot.org/uniprot/D2HRS1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. http://togogenome.org/gene/9646:KCNJ5 ^@ http://purl.uniprot.org/uniprot/D2GUX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.|||Membrane http://togogenome.org/gene/9646:SCNN1G ^@ http://purl.uniprot.org/uniprot/G1LXW8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:ARL5C ^@ http://purl.uniprot.org/uniprot/G1LC18 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9646:SYNE4 ^@ http://purl.uniprot.org/uniprot/G1L217 ^@ Similarity ^@ Belongs to the nesprin family. http://togogenome.org/gene/9646:BMP3 ^@ http://purl.uniprot.org/uniprot/D2GUF8 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9646:NSG2 ^@ http://purl.uniprot.org/uniprot/D2H5G0 ^@ Similarity ^@ Belongs to the NSG family. http://togogenome.org/gene/9646:CERS1 ^@ http://purl.uniprot.org/uniprot/G1LYF3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:CD9 ^@ http://purl.uniprot.org/uniprot/B1NH59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Cell membrane|||Membrane|||extracellular exosome http://togogenome.org/gene/9646:ACAA1 ^@ http://purl.uniprot.org/uniprot/D2GZQ8 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/9646:LOC100471797 ^@ http://purl.uniprot.org/uniprot/G1MJP9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:KLHL3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JFM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KLHL3 family.|||cytoskeleton|||cytosol http://togogenome.org/gene/9646:CDH3 ^@ http://purl.uniprot.org/uniprot/G1LMM1 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:FITM2 ^@ http://purl.uniprot.org/uniprot/D2H6K9 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9646:ASPH ^@ http://purl.uniprot.org/uniprot/A0A7N5P4I8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:CTSC ^@ http://purl.uniprot.org/uniprot/D2HR89 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C1 family.|||Lysosome|||Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains. http://togogenome.org/gene/9646:RFC5 ^@ http://purl.uniprot.org/uniprot/G1MCL9 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/9646:SSTR3 ^@ http://purl.uniprot.org/uniprot/G1MNJ6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:PIP4P2 ^@ http://purl.uniprot.org/uniprot/D2H4L0 ^@ Function|||Subcellular Location Annotation ^@ Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane|||phagosome membrane http://togogenome.org/gene/9646:WWP1 ^@ http://purl.uniprot.org/uniprot/G1L7C7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:LOC105236555 ^@ http://purl.uniprot.org/uniprot/A0A7N5P9Y8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGR2 family.|||Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.|||Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:LOC100476991 ^@ http://purl.uniprot.org/uniprot/G1MPF0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:RAB3D ^@ http://purl.uniprot.org/uniprot/D2HGW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/9646:KMT5C ^@ http://purl.uniprot.org/uniprot/A0A7N5JJS1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:LOC100480617 ^@ http://purl.uniprot.org/uniprot/G1MMX1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:AMBN ^@ http://purl.uniprot.org/uniprot/G1LGX0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ameloblastin family.|||Involved in the mineralization and structural organization of enamel.|||extracellular matrix http://togogenome.org/gene/9646:SLC26A10 ^@ http://purl.uniprot.org/uniprot/G1LF25 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:CNOT1 ^@ http://purl.uniprot.org/uniprot/D2GTZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT1 family.|||Nucleus http://togogenome.org/gene/9646:EFNA5 ^@ http://purl.uniprot.org/uniprot/A0A7N5K3Y1|||http://purl.uniprot.org/uniprot/G1L3C8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9646:UTP15 ^@ http://purl.uniprot.org/uniprot/D2I2V4 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9646:CPS1 ^@ http://purl.uniprot.org/uniprot/D2HJB0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:SNRPN ^@ http://purl.uniprot.org/uniprot/G1LKF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP SmB/SmN family.|||Nucleus http://togogenome.org/gene/9646:KCNN3 ^@ http://purl.uniprot.org/uniprot/D2HJN4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:CKAP2 ^@ http://purl.uniprot.org/uniprot/A0A7N5KI27 ^@ Similarity ^@ Belongs to the CKAP2 family. http://togogenome.org/gene/9646:CETN1 ^@ http://purl.uniprot.org/uniprot/D2HJY5 ^@ Similarity ^@ Belongs to the centrin family. http://togogenome.org/gene/9646:MMP12 ^@ http://purl.uniprot.org/uniprot/G1LMV7 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9646:CDPF1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JX93 ^@ Similarity ^@ Belongs to the CDPF1 family. http://togogenome.org/gene/9646:TIMM23 ^@ http://purl.uniprot.org/uniprot/G1LLS4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9646:PHF20 ^@ http://purl.uniprot.org/uniprot/D2H459 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:GPR161 ^@ http://purl.uniprot.org/uniprot/A0A7N5KFK4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:PYM1 ^@ http://purl.uniprot.org/uniprot/A0A7N5P720 ^@ Similarity|||Subunit ^@ Belongs to the pym family.|||Interacts (via N-terminus) with magoh and rbm8a; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex. http://togogenome.org/gene/9646:CCHCR1 ^@ http://purl.uniprot.org/uniprot/G1LV50 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be a regulator of keratinocyte proliferation or differentiation.|||Nucleus http://togogenome.org/gene/9646:WFIKKN1 ^@ http://purl.uniprot.org/uniprot/G1LKW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WFIKKN family.|||Secreted http://togogenome.org/gene/9646:OTOP3 ^@ http://purl.uniprot.org/uniprot/G1LR34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the otopetrin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:PLSCR1 ^@ http://purl.uniprot.org/uniprot/A0A7N5K6X5|||http://purl.uniprot.org/uniprot/A0A7N5KEI0 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/9646:ARL6IP5 ^@ http://purl.uniprot.org/uniprot/D2HPQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/9646:CILP ^@ http://purl.uniprot.org/uniprot/G1L7Y1 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9646:FAM227A ^@ http://purl.uniprot.org/uniprot/G1LVL5 ^@ Similarity ^@ Belongs to the FAM227 family. http://togogenome.org/gene/9646:MARS1 ^@ http://purl.uniprot.org/uniprot/G1LEG6 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9646:UBA52 ^@ http://purl.uniprot.org/uniprot/D2GV37 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Component of the 60S subunit of the ribosome. Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs.|||Cytoplasm|||In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.|||In the N-terminal section; belongs to the ubiquitin family.|||Nucleus|||Part of the 60S ribosomal subunit. Interacts with UBQLN1 (via UBA domain). http://togogenome.org/gene/9646:CHFR ^@ http://purl.uniprot.org/uniprot/G1M455 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CHFR family.|||PML body http://togogenome.org/gene/9646:CPNE6 ^@ http://purl.uniprot.org/uniprot/D2HG62 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9646:RHO ^@ http://purl.uniprot.org/uniprot/D2HGN0 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Contains one covalently linked retinal chromophore.|||Membrane http://togogenome.org/gene/9646:COPS5 ^@ http://purl.uniprot.org/uniprot/D2H427 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M67A family. CSN5 subfamily.|||synaptic vesicle http://togogenome.org/gene/9646:FMO2 ^@ http://purl.uniprot.org/uniprot/G1MF96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9646:POLR2B ^@ http://purl.uniprot.org/uniprot/A0A7N5K734 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/9646:ASPN ^@ http://purl.uniprot.org/uniprot/A0A7N5KJU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||extracellular matrix http://togogenome.org/gene/9646:A1CF ^@ http://purl.uniprot.org/uniprot/D2GZ28 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9646:RUVBL1 ^@ http://purl.uniprot.org/uniprot/D2H7C0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RuvB family.|||Dynein axonemal particle|||Nucleus|||Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. http://togogenome.org/gene/9646:NPM3 ^@ http://purl.uniprot.org/uniprot/D2GXV0 ^@ Similarity ^@ Belongs to the nucleoplasmin family. http://togogenome.org/gene/9646:MRPS14 ^@ http://purl.uniprot.org/uniprot/A0A7N5JJI4|||http://purl.uniprot.org/uniprot/D2HYZ4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS14 family. http://togogenome.org/gene/9646:RAB38 ^@ http://purl.uniprot.org/uniprot/D2HR88 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/9646:ZC3H15 ^@ http://purl.uniprot.org/uniprot/G1LNZ1 ^@ Similarity ^@ Belongs to the ZC3H15/TMA46 family. http://togogenome.org/gene/9646:LOC100476469 ^@ http://purl.uniprot.org/uniprot/D2HE84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9646:EAF2 ^@ http://purl.uniprot.org/uniprot/G1M6I0 ^@ Similarity ^@ Belongs to the EAF family. http://togogenome.org/gene/9646:AGPAT3 ^@ http://purl.uniprot.org/uniprot/D2HTK6 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9646:PPP1CA ^@ http://purl.uniprot.org/uniprot/G1L1P7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family. PP-1 subfamily.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9646:SH3RF2 ^@ http://purl.uniprot.org/uniprot/D2HQF4|||http://purl.uniprot.org/uniprot/G1MGT4 ^@ Similarity ^@ Belongs to the SH3RF family. http://togogenome.org/gene/9646:PPP1R1B ^@ http://purl.uniprot.org/uniprot/A0A7N5KR97 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 1 family. http://togogenome.org/gene/9646:RNF167 ^@ http://purl.uniprot.org/uniprot/G1LIJ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:ACOX3 ^@ http://purl.uniprot.org/uniprot/D2H4I0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/9646:RIC8B ^@ http://purl.uniprot.org/uniprot/A0A7N5J9Q3|||http://purl.uniprot.org/uniprot/D2HXV4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the synembryn family.|||Cytoplasm|||Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.|||Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. http://togogenome.org/gene/9646:KBTBD8 ^@ http://purl.uniprot.org/uniprot/G1LBI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KBTBD8 family.|||Golgi apparatus|||spindle http://togogenome.org/gene/9646:SIVA1 ^@ http://purl.uniprot.org/uniprot/A0A7N5K186 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.|||Nucleus http://togogenome.org/gene/9646:TJAP1 ^@ http://purl.uniprot.org/uniprot/A0A7N5KQY6|||http://purl.uniprot.org/uniprot/D2GZB7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:PKN2 ^@ http://purl.uniprot.org/uniprot/G1MCL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cleavage furrow|||Midbody|||Nucleus http://togogenome.org/gene/9646:ACTL6B ^@ http://purl.uniprot.org/uniprot/D2HX07 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9646:CRISPLD2 ^@ http://purl.uniprot.org/uniprot/G1MJ04 ^@ Similarity ^@ Belongs to the CRISP family. http://togogenome.org/gene/9646:LOC100472368 ^@ http://purl.uniprot.org/uniprot/D2HIU4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin family.|||Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.|||centrosome http://togogenome.org/gene/9646:PKP1 ^@ http://purl.uniprot.org/uniprot/A0A7N5J9M5 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/9646:NMD3 ^@ http://purl.uniprot.org/uniprot/A0A7N5KJX7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.|||Belongs to the NMD3 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:BNIP1 ^@ http://purl.uniprot.org/uniprot/A0A7N5P6S7|||http://purl.uniprot.org/uniprot/G1LXU0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:DGAT2L6 ^@ http://purl.uniprot.org/uniprot/G1LR57 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:BNIP3L ^@ http://purl.uniprot.org/uniprot/G1MD48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIP3 family.|||Membrane http://togogenome.org/gene/9646:PPP6R1 ^@ http://purl.uniprot.org/uniprot/D2HUV3 ^@ Similarity ^@ Belongs to the SAPS family. http://togogenome.org/gene/9646:SNCA ^@ http://purl.uniprot.org/uniprot/A0A7N5JWV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synuclein family.|||Membrane|||Nucleus|||Secreted|||Synapse|||axon http://togogenome.org/gene/9646:BEND6 ^@ http://purl.uniprot.org/uniprot/D2HAN6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:MRPS16 ^@ http://purl.uniprot.org/uniprot/G1MEV2 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/9646:CYGB ^@ http://purl.uniprot.org/uniprot/G1LUZ9 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9646:STK11IP ^@ http://purl.uniprot.org/uniprot/G1MES4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STK11IP family.|||Cytoplasm http://togogenome.org/gene/9646:LOC100478578 ^@ http://purl.uniprot.org/uniprot/G1LBC7 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Membrane|||sarcolemma http://togogenome.org/gene/9646:PPY ^@ http://purl.uniprot.org/uniprot/D2HCU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Secreted http://togogenome.org/gene/9646:GPM6B ^@ http://purl.uniprot.org/uniprot/A0A7N5JGB6|||http://purl.uniprot.org/uniprot/A0A7N5KDE0|||http://purl.uniprot.org/uniprot/G1MBU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/9646:SGCG ^@ http://purl.uniprot.org/uniprot/A0A7N5P8I0|||http://purl.uniprot.org/uniprot/D2HF48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/9646:ZRANB2 ^@ http://purl.uniprot.org/uniprot/A0A7N5KFW2|||http://purl.uniprot.org/uniprot/G1LAZ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZRANB2 family.|||Nucleus|||Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection. http://togogenome.org/gene/9646:YAE1 ^@ http://purl.uniprot.org/uniprot/D2GYH2 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9646:ASRGL1 ^@ http://purl.uniprot.org/uniprot/D2HS94 ^@ Similarity|||Subunit ^@ Belongs to the Ntn-hydrolase family.|||Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer. http://togogenome.org/gene/9646:FYTTD1 ^@ http://purl.uniprot.org/uniprot/G1LBP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UIF family.|||Nucleus speckle|||nucleoplasm http://togogenome.org/gene/9646:LOC100468875 ^@ http://purl.uniprot.org/uniprot/D2HYC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pancreatic ribonuclease family.|||Secreted http://togogenome.org/gene/9646:LOC100478335 ^@ http://purl.uniprot.org/uniprot/A0A7N5K9C6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:LOC100476918 ^@ http://purl.uniprot.org/uniprot/D2HD52 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9646:DDIT3 ^@ http://purl.uniprot.org/uniprot/D2H385 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family.|||Cytoplasm http://togogenome.org/gene/9646:CENPK ^@ http://purl.uniprot.org/uniprot/G1LXA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-K/MCM22 family.|||Nucleus|||centromere http://togogenome.org/gene/9646:HPX ^@ http://purl.uniprot.org/uniprot/G1MD79 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the hemopexin family.|||Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.|||Secreted http://togogenome.org/gene/9646:PIWIL2 ^@ http://purl.uniprot.org/uniprot/D2H044|||http://purl.uniprot.org/uniprot/G1L913 ^@ Similarity ^@ Belongs to the argonaute family. http://togogenome.org/gene/9646:RBBP5 ^@ http://purl.uniprot.org/uniprot/A0A7N5JGT4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:LOC100464006 ^@ http://purl.uniprot.org/uniprot/A0A7N5K2E6 ^@ Similarity ^@ Belongs to the intercrine beta (chemokine CC) family. http://togogenome.org/gene/9646:ARV1 ^@ http://purl.uniprot.org/uniprot/G1L6W8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARV1 family.|||Endoplasmic reticulum membrane|||Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.|||Membrane http://togogenome.org/gene/9646:PSD ^@ http://purl.uniprot.org/uniprot/G1MHE4 ^@ Subcellular Location Annotation ^@ Membrane|||ruffle membrane http://togogenome.org/gene/9646:CAPN6 ^@ http://purl.uniprot.org/uniprot/D2HEA2 ^@ Caution|||Similarity ^@ Belongs to the peptidase C2 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:LOC100480024 ^@ http://purl.uniprot.org/uniprot/D2HWJ2 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9646:SMIM8 ^@ http://purl.uniprot.org/uniprot/A0A7N5KH18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM8 family.|||Membrane http://togogenome.org/gene/9646:SBNO1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JI57 ^@ Similarity ^@ Belongs to the SBNO family. http://togogenome.org/gene/9646:LOC100469088 ^@ http://purl.uniprot.org/uniprot/G1L7K2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/9646:GABRP ^@ http://purl.uniprot.org/uniprot/D2HKP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9646:APOC4 ^@ http://purl.uniprot.org/uniprot/G1M237 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the apolipoprotein C4 family.|||May participate in lipoprotein metabolism.|||Secreted http://togogenome.org/gene/9646:LOC100474740 ^@ http://purl.uniprot.org/uniprot/G1MJX5 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:WNT16 ^@ http://purl.uniprot.org/uniprot/D2HJH3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9646:ZNF483 ^@ http://purl.uniprot.org/uniprot/G1MHZ5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:RPA3 ^@ http://purl.uniprot.org/uniprot/D2HD14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the replication factor A protein 3 family.|||Nucleus http://togogenome.org/gene/9646:LOC100468201 ^@ http://purl.uniprot.org/uniprot/D2I0V9 ^@ Function|||Similarity ^@ Belongs to the SAA family.|||Major acute phase reactant. Apolipoprotein of the HDL complex. http://togogenome.org/gene/9646:NR1H2 ^@ http://purl.uniprot.org/uniprot/D2H7T4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9646:NOL10 ^@ http://purl.uniprot.org/uniprot/G1LYD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat NOL10/ENP2 family.|||nucleolus http://togogenome.org/gene/9646:MFSD11 ^@ http://purl.uniprot.org/uniprot/D2H993 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/9646:SLC7A7 ^@ http://purl.uniprot.org/uniprot/D2HTV4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:SMARCAL1 ^@ http://purl.uniprot.org/uniprot/G1L9L8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.|||Nucleus http://togogenome.org/gene/9646:NOP16 ^@ http://purl.uniprot.org/uniprot/G1LKA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP16 family.|||nucleolus http://togogenome.org/gene/9646:NOC2L ^@ http://purl.uniprot.org/uniprot/G1MDP3 ^@ Similarity ^@ Belongs to the NOC2 family. http://togogenome.org/gene/9646:ART4 ^@ http://purl.uniprot.org/uniprot/G1LSN6 ^@ Similarity ^@ Belongs to the Arg-specific ADP-ribosyltransferase family. http://togogenome.org/gene/9646:DHRS7C ^@ http://purl.uniprot.org/uniprot/G1M086 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9646:RPL12 ^@ http://purl.uniprot.org/uniprot/F2X246 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL11 family.|||Binds directly to 26S ribosomal RNA. http://togogenome.org/gene/9646:CSF2 ^@ http://purl.uniprot.org/uniprot/A0A7N5KI24 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GM-CSF family.|||Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.|||Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.|||Secreted http://togogenome.org/gene/9646:TM2D2 ^@ http://purl.uniprot.org/uniprot/D2HRV9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:FOXN2 ^@ http://purl.uniprot.org/uniprot/D2GUB8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:MTHFR ^@ http://purl.uniprot.org/uniprot/G1LTB1 ^@ Similarity ^@ Belongs to the methylenetetrahydrofolate reductase family. http://togogenome.org/gene/9646:STC2 ^@ http://purl.uniprot.org/uniprot/D2H5F6 ^@ Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9646:CRHR2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JY89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Membrane http://togogenome.org/gene/9646:NUBPL ^@ http://purl.uniprot.org/uniprot/G1MB55 ^@ Similarity ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. http://togogenome.org/gene/9646:FCGR1A ^@ http://purl.uniprot.org/uniprot/G1LKK5 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9646:PFDN4 ^@ http://purl.uniprot.org/uniprot/G1M3F1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/9646:WASHC3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JHI2 ^@ Similarity ^@ Belongs to the CCDC53 family. http://togogenome.org/gene/9646:SLC46A1 ^@ http://purl.uniprot.org/uniprot/G1LEG4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:TBPL1 ^@ http://purl.uniprot.org/uniprot/D2HJ41 ^@ Similarity|||Subunit ^@ Belongs to the TBP family.|||Binds TFIIA and TFIIB. http://togogenome.org/gene/9646:LOC100465553 ^@ http://purl.uniprot.org/uniprot/D2I817 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:FAM234A ^@ http://purl.uniprot.org/uniprot/D2HDV6 ^@ Similarity ^@ Belongs to the FAM234 family. http://togogenome.org/gene/9646:LOC100478886 ^@ http://purl.uniprot.org/uniprot/G1MKY7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:SFRP1 ^@ http://purl.uniprot.org/uniprot/D2H9Q0 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9646:SLC29A3 ^@ http://purl.uniprot.org/uniprot/G1MHA5 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/9646:LOC100478321 ^@ http://purl.uniprot.org/uniprot/D2H9P4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9646:LMBR1L ^@ http://purl.uniprot.org/uniprot/G1LJZ5 ^@ Similarity ^@ Belongs to the LIMR family. http://togogenome.org/gene/9646:VTI1B ^@ http://purl.uniprot.org/uniprot/D2HRG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/9646:PRKD3 ^@ http://purl.uniprot.org/uniprot/D2H089 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.|||Membrane http://togogenome.org/gene/9646:LOC100467789 ^@ http://purl.uniprot.org/uniprot/A0A7N5KF74 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9646:ATP6V1A ^@ http://purl.uniprot.org/uniprot/A0A7N5JXT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Vesicle|||clathrin-coated vesicle membrane|||secretory vesicle http://togogenome.org/gene/9646:NLN ^@ http://purl.uniprot.org/uniprot/A0A7N5K055 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/9646:LRRC8A ^@ http://purl.uniprot.org/uniprot/D2H153 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9646:PDF ^@ http://purl.uniprot.org/uniprot/D2HLI5 ^@ Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. http://togogenome.org/gene/9646:ATG9A ^@ http://purl.uniprot.org/uniprot/A0A7N5KPY8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.|||Preautophagosomal structure membrane http://togogenome.org/gene/9646:HSPA13 ^@ http://purl.uniprot.org/uniprot/G1M762 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 70 family.|||Binds UBQLN2.|||Endoplasmic reticulum|||Has peptide-independent ATPase activity.|||Microsome http://togogenome.org/gene/9646:GSPT2 ^@ http://purl.uniprot.org/uniprot/D2I687 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. http://togogenome.org/gene/9646:LOC100467558 ^@ http://purl.uniprot.org/uniprot/A0A7N5P1J0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFC2 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9646:LAMP3 ^@ http://purl.uniprot.org/uniprot/A0A7N5JGL8|||http://purl.uniprot.org/uniprot/G1MC11 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9646:KAT5 ^@ http://purl.uniprot.org/uniprot/A0A7N5K8I8|||http://purl.uniprot.org/uniprot/D2H4P7|||http://purl.uniprot.org/uniprot/G1MG58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/9646:OOEP ^@ http://purl.uniprot.org/uniprot/G1LMP1 ^@ Similarity ^@ Belongs to the KHDC1 family. http://togogenome.org/gene/9646:TPM1 ^@ http://purl.uniprot.org/uniprot/A0A7N5P393|||http://purl.uniprot.org/uniprot/G1LL03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9646:HTR1B ^@ http://purl.uniprot.org/uniprot/G1MMS2 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.|||Homodimer. Heterodimer with HTR1D.|||Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.|||Membrane|||Palmitoylated.|||Phosphorylated. http://togogenome.org/gene/9646:LOC100466794 ^@ http://purl.uniprot.org/uniprot/D2GWW0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase g subunit family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. http://togogenome.org/gene/9646:ZKSCAN1 ^@ http://purl.uniprot.org/uniprot/D2I5F1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9646:AGTRAP ^@ http://purl.uniprot.org/uniprot/A0A7N5JQ24 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:DAND5 ^@ http://purl.uniprot.org/uniprot/D2HG20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Secreted http://togogenome.org/gene/9646:CHRNA2 ^@ http://purl.uniprot.org/uniprot/G1KZY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9646:STK11 ^@ http://purl.uniprot.org/uniprot/A0A7N5KJH6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily. http://togogenome.org/gene/9646:COMTD1 ^@ http://purl.uniprot.org/uniprot/D2HIC8 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. http://togogenome.org/gene/9646:CNOT9 ^@ http://purl.uniprot.org/uniprot/A0A7N5J8T2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT9 family.|||P-body http://togogenome.org/gene/9646:SMIM18 ^@ http://purl.uniprot.org/uniprot/A0A7N5P5Z8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9646:FIBIN ^@ http://purl.uniprot.org/uniprot/D2HUT9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FIBIN family.|||Endoplasmic reticulum|||Golgi apparatus|||Homodimer; disulfide-linked. Seems to also exist as monomers.|||Secreted http://togogenome.org/gene/9646:LOC100475569 ^@ http://purl.uniprot.org/uniprot/D2HK82 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:GHRL ^@ http://purl.uniprot.org/uniprot/B0ZE69|||http://purl.uniprot.org/uniprot/G1MC20 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the motilin family.|||Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.|||O-octanoylation is essential for ghrelin activity.|||Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.|||Secreted http://togogenome.org/gene/9646:SLC6A19 ^@ http://purl.uniprot.org/uniprot/G1LV25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9646:PRF1 ^@ http://purl.uniprot.org/uniprot/D2GXG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Secreted http://togogenome.org/gene/9646:EIF1AD ^@ http://purl.uniprot.org/uniprot/G1MFU7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the EIF1AD family.|||Interacts with GAPDH and STAT1.|||Plays a role into cellular response to oxidative stress. Decreases cell proliferation. http://togogenome.org/gene/9646:DNAJC27 ^@ http://purl.uniprot.org/uniprot/A0A7N5JMI7 ^@ Function|||Subunit ^@ GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.|||Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms). http://togogenome.org/gene/9646:PTK2B ^@ http://purl.uniprot.org/uniprot/A0A7N5KFQ2|||http://purl.uniprot.org/uniprot/A0A7N5KJS2|||http://purl.uniprot.org/uniprot/D2GZ67 ^@ Subcellular Location Annotation ^@ Cell membrane|||cell cortex|||focal adhesion http://togogenome.org/gene/9646:EDN1 ^@ http://purl.uniprot.org/uniprot/G1L7K0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Secreted http://togogenome.org/gene/9646:GIP ^@ http://purl.uniprot.org/uniprot/G1LEN0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.|||Secreted http://togogenome.org/gene/9646:SMPD3 ^@ http://purl.uniprot.org/uniprot/D2HLJ6 ^@ Similarity ^@ Belongs to the neutral sphingomyelinase family. http://togogenome.org/gene/9646:LOC100470989 ^@ http://purl.uniprot.org/uniprot/D2I623 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9646:RTRAF ^@ http://purl.uniprot.org/uniprot/G1L5Q6 ^@ Similarity ^@ Belongs to the RTRAF family. http://togogenome.org/gene/9646:RPL11 ^@ http://purl.uniprot.org/uniprot/D7RAF3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL5 family. http://togogenome.org/gene/9646:PLA2G5 ^@ http://purl.uniprot.org/uniprot/G1L8Z8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9646:GDPD2 ^@ http://purl.uniprot.org/uniprot/G1LRW0 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9646:GPR171 ^@ http://purl.uniprot.org/uniprot/D2H3Z6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9646:KCNB2 ^@ http://purl.uniprot.org/uniprot/A0A7N5JB91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.|||Cell membrane|||Membrane|||Perikaryon|||dendrite http://togogenome.org/gene/9646:MTFP1 ^@ http://purl.uniprot.org/uniprot/G1LM10 ^@ Similarity ^@ Belongs to the MTFP1 family. http://togogenome.org/gene/9646:GRPEL1 ^@ http://purl.uniprot.org/uniprot/A0A7N5JFN0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GrpE family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion matrix http://togogenome.org/gene/9646:HIBADH ^@ http://purl.uniprot.org/uniprot/G1LGZ3 ^@ Similarity ^@ Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily. http://togogenome.org/gene/9646:ARPC4 ^@ http://purl.uniprot.org/uniprot/A0A7N5JZ90 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARPC4 family.|||Cell projection|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.|||cytoskeleton http://togogenome.org/gene/9646:CTSA ^@ http://purl.uniprot.org/uniprot/D2HZ11 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/9646:UBE4A ^@ http://purl.uniprot.org/uniprot/G1M3C0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin conjugation factor E4 family.|||Cytoplasm|||The U-box domain is required for the ubiquitin protein ligase activity.|||Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. http://togogenome.org/gene/9646:TSPO2 ^@ http://purl.uniprot.org/uniprot/D2I3I2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TspO/BZRP family.|||Membrane http://togogenome.org/gene/9646:FAM162A ^@ http://purl.uniprot.org/uniprot/A0A7N5J8I2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0389 family.|||Membrane http://togogenome.org/gene/9646:MAP7D3 ^@ http://purl.uniprot.org/uniprot/A0A7N5P8P8 ^@ Similarity ^@ Belongs to the MAP7 family. http://togogenome.org/gene/9646:RTF2 ^@ http://purl.uniprot.org/uniprot/G1LKJ9 ^@ Similarity|||Subunit ^@ Belongs to the rtf2 family.|||Interacts with DDI2; probably also interacts with DDI1. http://togogenome.org/gene/9646:KCNJ13 ^@ http://purl.uniprot.org/uniprot/D2H845 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9646:SDE2 ^@ http://purl.uniprot.org/uniprot/D2HVM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SDE2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9646:KDR ^@ http://purl.uniprot.org/uniprot/A0A7N5JCT5|||http://purl.uniprot.org/uniprot/G1MJC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane